Refine
Has Fulltext
- no (56) (remove)
Year of publication
- 2020 (56) (remove)
Document Type
- Doctoral Thesis (56) (remove)
Language
- English (56) (remove)
Keywords
- Migration (2)
- Wissensmanagement (2)
- knowledge management (2)
- AIDS (1)
- AMP (1)
- Active Labor Market Programs (1)
- Aktinzytoskelett (1)
- America (1)
- American studies (1)
- Amerika (1)
- Amerikastudien (1)
- Bayesian inference (1)
- Bildanalyse (1)
- Biohacking (1)
- Biologie (1)
- Biomimetics (1)
- Biomimetik (1)
- Biopolitik (1)
- Biotechnology (1)
- Bula Matadi (1)
- Causal Inference (1)
- Childhoods (1)
- Corporate Entrepreneurship (1)
- DIY (1)
- Denkstile (1)
- Designed Biointerfaces (1)
- Designte Biointerface (1)
- Diagnostik (1)
- Do-it-yourself (1)
- E. coli (1)
- EEG (1)
- Escherichia coli (1)
- Evolution (1)
- Extracellular Matrix (1)
- Extrazelluläre Matrix (1)
- Flüchtlingskrise (1)
- Frontier Conviviality (1)
- Genomik (1)
- Germany (1)
- Geschäftsbeziehungstypen (1)
- Geschäftsverhandlungen (1)
- Gilbert Imlay (1)
- Glycoproteins (1)
- Glykoproteine (1)
- Graphitic carbon nitride (1)
- Griffithsin (1)
- Grundschule (1)
- HIV (1)
- Herschel Island Qikiqtaruk (1)
- Himalaya (1)
- Hybrid materials synthesis (1)
- Immigration (1)
- India (1)
- Innovation Management (1)
- Intentional communities (1)
- Intrapreneurship (1)
- Kognitionswissenschaft (1)
- Kommunen (1)
- Koordination (1)
- Kulturwissenschaft (1)
- Körper (1)
- L-edge spectroscopy (1)
- Langmuir-Schaefer method (1)
- Langmuir-Schäfer-Methode (1)
- Lernverlauf (1)
- Magnetotactic bacteria (1)
- Marie Howland (1)
- Mathematik (1)
- Medizin (1)
- Metabolic Engineering (1)
- Ministerial bureaucracy (1)
- Ministerialbürokratie (1)
- Moonlets (1)
- Motivation zur Wissensteilung (1)
- Multi-Issue-Verhandlungen (1)
- Narrative (1)
- Nathaniel Hawthorne (1)
- National narrative (1)
- Naturschutz (1)
- Netzwerke (1)
- Nicotiana tabacum (1)
- Nineteenth century (1)
- Permafrost carbon feedback (1)
- Pflanzenzellen (1)
- Photopolymerization (1)
- Photorespiration (1)
- Polymers (1)
- Populationsgenetik (1)
- Propellers (1)
- Resonances (1)
- Rings (1)
- SUMO (1)
- Saturn (1)
- Siberia (1)
- Skalenentwicklung (1)
- Start-Up Subsidies (1)
- Survey-Experiment (1)
- Sutton E. Griggs (1)
- Synthetic Biology (1)
- USA (1)
- Utopia (1)
- Utopian communities (1)
- Utopie (1)
- Verarbeitung natürlicher Sprache (1)
- W.E.B. Du Bois (1)
- Wissensteilung (1)
- Zahnwale (1)
- Zellform (1)
- Zielausrichtung (1)
- Zielsetzungsstrategien (1)
- Zielumfang (1)
- actin cytoskeleton machine (1)
- action processing (1)
- active layer (1)
- anomalous diffusion (1)
- anti bacterial (1)
- antimicrobial peptide (1)
- antiviral agent (1)
- artificial intelligence (1)
- assessment (1)
- attribution (1)
- biocultures (1)
- biohacking (1)
- biology (1)
- biomarker (1)
- biophysics (1)
- biopolitics (1)
- biotechnology (1)
- body (1)
- business negotiations (1)
- business relationship types (1)
- carbon density (1)
- celestial mechanics (1)
- cell morphogenesis (1)
- cell shape (1)
- cells epidermis (1)
- charge-transfer excitations (1)
- chloroplast (1)
- cognitive science (1)
- conservation (1)
- constraint-based modeling (1)
- coordination (1)
- countermeasures (1)
- cultural narratives (1)
- cultural studies (1)
- culture (1)
- cybersecurity (1)
- decolonial feminism (1)
- diffusion (1)
- early numeracy (1)
- electrical resistivity (1)
- electronic structure (1)
- emotions (1)
- employee driven innovation (1)
- employee involvement in innovation (1)
- energy metabolism (1)
- evolution (1)
- formate assimilation (1)
- formate dehydrogenases (1)
- genomics (1)
- glacial and interglacial permafrost (1)
- goal orientation (1)
- goal scope (1)
- goal setting strategies (1)
- hydrodynamics (1)
- identity politics (1)
- imitation (1)
- immigration (1)
- inducible expression (1)
- infancy (1)
- innovative behaviour (1)
- institutional crisis (1)
- institutionelle Krise (1)
- international law (1)
- intersectionality (1)
- iron (1)
- isotopes (1)
- knowledge sharing (1)
- knowledge sharing motivation (1)
- künstliche Intelligenz (1)
- lagoons (1)
- language (1)
- large deviation theory (1)
- learning networks plant (1)
- learning progression (1)
- life sciences (1)
- magnetic beads (1)
- magnetism (1)
- mathematics (1)
- mechanobiology (1)
- medicine (1)
- metabolic engineering (1)
- metabolic networks (1)
- metabolism (1)
- methane (1)
- methanogenic archaea (1)
- methanol assimilation (1)
- micorbicide (1)
- microfluidics (1)
- microscopy (1)
- migration (1)
- modulation (1)
- molecular farming (1)
- multi-issue negotiations (1)
- natural language processing (1)
- numerische Basisfähigkeiten (1)
- organic carbon cycle (1)
- pavement cells image analysis (1)
- peptide (1)
- permafrost (1)
- photo-chemical pathways (1)
- planets and satellites: rings (1)
- plant (1)
- plasmidome (1)
- plastid transformation (1)
- polypeptide (1)
- population genetics (1)
- primary school (1)
- protein fusion (1)
- public management (1)
- recombinant production (1)
- refugee crisis (1)
- representation (1)
- rivers (1)
- salt diffusion (1)
- scale development (1)
- scattering (1)
- self-defence (1)
- single-cell (1)
- social cognition (1)
- social media (1)
- statistical physics (1)
- stress-tolerance genes (1)
- submarine (1)
- subsea (1)
- survey experiment (1)
- thermokarst (1)
- thinking styles (1)
- tissue growth (1)
- toothed whales (1)
- transgenic (1)
- transition metal complexes (1)
- whole genome (1)
- öffentliche BWL (1)
Institute
- Institut für Biochemie und Biologie (14)
- Institut für Anglistik und Amerikanistik (7)
- Institut für Chemie (7)
- Institut für Physik und Astronomie (5)
- Institut für Ernährungswissenschaft (4)
- Institut für Geowissenschaften (3)
- Öffentliches Recht (3)
- Department Psychologie (2)
- Extern (2)
- Fachgruppe Betriebswirtschaftslehre (2)
Addressing both scholars of international law and political science as well as decision makers involved in cybersecurity policy, the book tackles the most important and intricate legal issues that a state faces when considering a reaction to a malicious cyber operation conducted by an adversarial state. While often invoked in political debates and widely analysed in international legal scholarship, self-defence and countermeasures will often remain unavailable to states in situations of cyber emergency due to the pervasive problem of reliable and timely attribution of cyber operations to state actors. Analysing the legal questions surrounding attribution in detail, the book presents the necessity defence as an evidently available alternative. However, the shortcomings of the doctrine as based in customary international law that render it problematic as a remedy for states are examined in-depth. In light of this, the book concludes by outlining a special emergency regime for cyberspace.
TrainTrap
(2020)
‘The Territorialities of U.S. Imperialisms’ sets into relation U.S. imperial and Indigenous conceptions of territoriality as articulated in U.S. legal texts and Indigenous life writing in the 19th century. It analyzes the ways in which U.S. legal texts as “legal fictions” narratively press to affirm the United States’ territorial sovereignty and coherence in spite of its reliance on a variety of imperial practices that flexibly disconnect and (re)connect U.S. sovereignty, jurisdiction and territory.
At the same time, the book acknowledges Indigenous life writing as legal texts in their own right and with full juridical force, which aim to highlight the heterogeneity of U.S. national territory both from their individual perspectives and in conversation with these legal fictions. Through this, the book’s analysis contributes to a more nuanced understanding of the coloniality of U.S. legal fictions, while highlighting territoriality as a key concept in the fashioning of the narrative of U.S. imperialism.
Plants are an attractive platform for the production of medicinal compounds because of their potential to generate large amounts of biomass cheaply. The use of chloroplast transformation is an attractive way to achieve the recombinant production of proteins in plants, because of the chloroplasts’ high capacity to produce foreign proteins in comparison to nuclear transformed plants. In this thesis, the production of two different types of antimicrobial polypeptides in chloroplasts is explored.
The first example is the production of the potent HIV entry inhibitor griffithsin. Griffithsin has the potential to prevent HIV infections by blocking the entry of the virus into human cells. Here the use of transplastomic plants as an inexpensive production method for griffithsin was explored. Transplastomic plants grew healthily and were able to accumulate griffithsin to up to 5% of the total soluble protein. Griffithsin could easily be purified from tobacco leaf tissue and had a similarly high neutralization activity as griffithsin recombinantly produced in bacteria. Griffithsin could be purified from dried tobacco leaves, demonstrating that dried leaves could be used as a storable starting material for griffithsin purification, circumventing the need for immediate purification after harvest.
The second example is the production of antimicrobial peptides (AMPs) that have the capacity to kill bacteria and are an attractive alternative to currently used antibiotics that are increasingly becoming ineffective. The production of antimicrobial peptides was considerably more challenging than the production of griffithsin. Small AMPs are prone to degradation in plastids. This problem was overcome by fusing AMPs to generate larger polypeptides. In one approach, AMPs were fused to each other to increase size and combine the mode of action of multiple AMPs. This improved the accumulation of AMPs but also resulted in impaired plant growth. This was solved by the use of two different inducible systems, which could largely restore plant growth. Fusions of multiple AMPs were insoluble and could not be purified.
In addition to fusing AMPs to each other, the fusion of AMPs to small ubiquitin-like modifier (SUMO), was tested as an approach to improve the accumulation, facilitate purification, and reduce the toxicity of AMPs to chloroplasts. Fusion of AMPs to SUMO indeed increased accumulation while reducing the toxicity to the plants. SUMO fusions produced inside chloroplasts could be purified, and SUMO could be efficiently cleaved off with the SUMO protease. Such fusions therefore provide a promising strategy for the production of AMPs and other small polypeptides inside chloroplasts.
One of the tremendous discoveries by the Cassini spacecraft has been the detection of propeller structures in Saturn's A ring. Although the generating moonlet is too small to be resolved by the cameras aboard Cassini, its produced density structure within the rings, caused by its gravity can be well observed. The largest observed propeller is called Blériot and has an azimuthal extent over several thousand kilometers. Thanks to its large size, Blériot could be identified in different images over a time span of over 10 years, allowing the reconstruction of its orbital evolution. It turns out that Blériot deviates considerably from its expected Keplerian orbit in azimuthal direction by several thousand kilometers. This excess motion can be well reconstructed by a superposition of three harmonics, and therefore resembles the typical fingerprint of a resonantly perturbed body. This PhD thesis is directed to the excess motion of Blériot. Resonant perturbations are a known for some of the outer satellites of Saturn. Thus, in the first part of this thesis, we seek for suiting resonance candidates nearby the propeller, which might explain the observed periods and amplitudes. In numeric simulations, we show that indeed resonances by Prometheus, Pandora and Mimas can explain the libration periods in good agreement, but not the amplitudes. The amplitude problem is solved by the introduction of a propeller-moonlet interaction model, where we assume a broken symmetry of the propeller by a small displacement of the moonlet. This results in a librating motion the moonlet around the propeller's symmetry center due to the non-vanishing accelerations. The retardation of the reaction of the propeller structure to the motion of the moonlet causes the propeller to become asymmetric. Hydrodynamic simulations to test our analytical model confirm our predictions. In the second part of this thesis, we consider a stochastic migration of the moonlet, which is an alternative hypothesis to explain the observed excess motion of Blériot. The mean-longitude is a time-integrated quantity and thus introduces a correlation between the independent kicks of a random walk, smoothing the noise and thus makes the residual look similar to the observed one for Blériot. We apply a diagonalization test to decorrelated the observed residuals for the propellers Blériot and Earhart and the ring-moon Daphnis. It turns out that the decorrelated distributions do not strictly follow the expected Gaussian distribution. The decorrelation method fails to distinguish a correlated random walk from a noisy libration and thus we provide an alternative study. Assuming the three-harmonic fit to be a valid representation of the excess motion for Blériot, independently from its origin, we test the likelihood that this excess motion can be created by a random walk. It turns out that a non-correlated and correlated random walk is unlikely to explain the observed excess motion.
With populations growing worldwide and climate change threatening food production there is an urgent need to find ways to ensure food security. Increasing carbon fixation rate in plants is a promising approach to boost crop yields. The carbon-fixing enzyme Rubisco catalyzes, beside the carboxylation reaction, also an oxygenation reaction that generates glycolate-2P, which needs to be recycled via a metabolic route termed photorespiration. Photorespiration dissipates energy and most importantly releases previously fixed CO2, thus significantly lowering carbon fixation rate and yield. Engineering plants to omit photorespiratory CO2 release is the goal of the FutureAgriculture consortium and this thesis is part of this collaboration. The consortium aims to establish alternative glycolate-2P recycling routes that do not release CO2. Ultimately, they are expected to increase carbon fixation rates and crop yields. Natural and novel reactions, which require enzyme engineering, were considered in the pathway design process. Here I describe the engineering of two pathways, the arabinose-5P and the erythrulose shunt. They were designed to recycle glycolate-2P via glycolaldehyde into a sugar phosphate and thereby reassimilate glycolate-2P to the Calvin cycle. I used Escherichia coli gene deletion strains to validate and characterize the activity of both synthetic shunts. The strains’ auxotrophies can be alleviated by the activity of the synthetic route, thus providing a direct way to select for pathway activity. I introduced all pathway components to these dedicated selection strains and discovered inhibitions, limitations and metabolic cross talk interfering with pathway activity. After resolving these issues, I was able to show the in vivo activity of all pathway components and combine them into functional modules.. Specifically, I demonstrate the activity of a new-to-nature module of glycolate reduction to glycolaldehyde. Also, I successfully show a new glycolaldehyde assimilation route via arabinose-5P to ribulose-5P. In addition, all necessary enzymes for glycolaldehyde assimilation via L-erythrulose were shown to be active and an L-threitol assimilation route via L-erythrulose was established in E. coli. On their own, these findings demonstrate the power of using an easily engineerable microbe to test novel pathways; combined, they will form the basis for implementing photorespiration bypasses in plants.
The ability of a company to innovate and to launch innovation is a critical competitive edge to remain competitive in the 21st century. Large organizations therefore increasingly recognize employees as a significant factor and critical source of innovation. Several studies assert the fact that every employee has to offer certain skills and knowledge and can contribute to innovation. Hence, every employee has a certain ‘entrepreneurial potential’. This potential can be expressed in the form of entrepreneurial behaviour and can occur in many ways, from monopersonal innovation championing to several small scale contributions, where several individuals team up for innovation. To support entrepreneurial behaviour of their employees, large organizations increasingly rely on Corporate Entrepreneurship. They set up organizational structures and venturing units, offer vehicles and tools to their employees to be more entrepreneurial. The evolvement of new tools and technologies thereby allow for new ways of employee involvement, also allowing for more radical innovation to be developed collaboratively. Yet, many of such offerings fail to achieve the desired outcome. While some employees immediately opt-in for innovation, others do not and their entrepreneurial potential remains untapped. This research explores how large organizations can better support their employees to express their entrepreneurial potential, thus moving from non-entrepreneurial behaviour or not wanting to be involved, to actually expressing entrepreneurial behaviour. The underlying research therefore is two-fold. While focusing on the individual level and the entrepreneurial behaviour of employees, this research also takes the organizational perspective into account in order to identify how non-entrepreneurial behaviour can be stimulated towards entrepreneurial behaviour. Using an empirical qualitative research design based on pragmatism and abduction, data is collected by means of qualitative interviews as well as a longitudinal use case setting. Grounded theory is then applied for analysis and sense making. The main outcome is a theoretical model of why employees are expressing or not expressing their entrepreneurial potential and how non-expression can potentially be triggered towards entrepreneurial behaviour. The results indicate that there is no one-size-fits all model of Corporate Entrepreneurship. This research therefore argues that organizations can achieve higher levels of entrepreneurial behaviour when addressing employees differently. By developing a theoretical model as well as suggestions of how this model can be applied in practice, this research contributes to theory and practice alike. This document closes suggesting future research areas around supporting employees to express their entrepreneurial potential.