Refine
Has Fulltext
- no (872) (remove)
Year of publication
Document Type
- Article (697)
- Doctoral Thesis (75)
- Conference Proceeding (36)
- Review (31)
- Other (27)
- Monograph/Edited Volume (2)
- Habilitation Thesis (2)
- Preprint (2)
Language
- English (872) (remove)
Is part of the Bibliography
- yes (872)
Keywords
- inflammation (13)
- insulin resistance (9)
- Biomarker (8)
- Caenorhabditis elegans (8)
- oxidative stress (8)
- type 2 diabetes (8)
- FGF21 (7)
- LC-MS/MS (7)
- Manganese (7)
- Oxidative stress (7)
- cancer (7)
- carotenoids (7)
- insulin (7)
- obesity (7)
- Pregnancy (6)
- acid sphingomyelinase (6)
- ceramide (6)
- epigenetics (6)
- sphingolipids (6)
- Aging (5)
- Arsenolipids (5)
- DNA methylation (5)
- Dexamethasone (5)
- Fetal programming (5)
- HPLC (5)
- Insulin resistance (5)
- Sphingolipids (5)
- Sphingosine 1-phosphate (5)
- adipose tissue (5)
- cytokines (5)
- linagliptin (5)
- metabolism (5)
- pregnancy (5)
- vitamin A (5)
- α-amylase/trypsin inhibitors (5)
- Arsenic-containing fatty acids (4)
- Arsenic-containing hydrocarbons (4)
- C. elegans (4)
- Carotenoids (4)
- Endothelin (4)
- Epigenetics (4)
- Mass spectrometry (4)
- Mitochondria (4)
- NASH (4)
- Prunus avium L. (4)
- SDS-PAGE (4)
- Solanaceae (4)
- Sphingosine-1-phosphate (4)
- Vitamin A (4)
- Zinc (4)
- aging (4)
- cardiovascular disease (4)
- chronic kidney disease (4)
- malnutrition (4)
- protein (4)
- retinol (4)
- retinol-binding protein 4 (4)
- transcriptomics (4)
- type 2 diabetes mellitus (4)
- Bioavailability (3)
- Boron exposure (3)
- Cardiovascular diseases (3)
- DNA damage (3)
- Diabetic nephropathy (3)
- Emulsion (3)
- Flower buds (3)
- GDF15 (3)
- Glucosinolates (3)
- Hepatocytes (3)
- Hypertension (3)
- Kidney (3)
- LC–MS/MS (3)
- Meta-analysis (3)
- Methylmercury (3)
- NAFLD (3)
- NZO (3)
- Neurotoxicity (3)
- Nutrition (3)
- Obesity (3)
- Placenta (3)
- Skeletal muscle (3)
- Sphingosine kinase (3)
- Stability (3)
- Toxicity (3)
- adiponectin (3)
- cholesterol (3)
- diabetes (3)
- diabetic nephropathy (3)
- disease (3)
- electrochemistry (3)
- genes (3)
- iCheck (3)
- lutein (3)
- metabolic syndrome (3)
- plasma (3)
- polyphenols (3)
- prevention (3)
- probiotics (3)
- proteinuria (3)
- resistin (3)
- sphingosine (3)
- survival (3)
- wheat (3)
- zinc (3)
- Abscisic acid (2)
- Acid sphingomyelinase (2)
- Adipose tissue (2)
- African indigenous vegetables (2)
- Ageing (2)
- Alterung (2)
- Amino acids (2)
- Amylase (2)
- Apoptosis (2)
- Arabidopsis (2)
- Arsenic (2)
- Beer (2)
- Birth weight (2)
- Blood pressure (2)
- Boric acid (2)
- C-reactive protein (2)
- Caco-2 intestinal barrier model (2)
- Camellia sinensis (2)
- Carotenoid (2)
- Ceramide (2)
- Ceramides (2)
- Cereals (2)
- Clinical (2)
- Cohort studies (2)
- Copper (2)
- Cytotoxicity (2)
- DPP-4 inhibitors (2)
- Development (2)
- Diabetes (2)
- Doehlert design (2)
- Dopamine (2)
- Dormancy (2)
- Drug delivery (2)
- ET-1 (2)
- Endothelial cells (2)
- Endothelin-1 (2)
- FTY720 (2)
- Fluorescence (2)
- Food labeling (2)
- Foxp3 (2)
- GCN2 (2)
- Genotoxicity (2)
- Gestational diabetes mellitus (2)
- HRMS (2)
- IL-8 transcription (2)
- In vitro blood-brain barrier model (2)
- Inflammation (2)
- Insulin secretion (2)
- Labile zinc (2)
- Linagliptin (2)
- MALDI-TOF-MS (2)
- Meat (2)
- Mediterranean diet (2)
- Mendelian randomization (2)
- Mercuric mercury (2)
- Modified mycotoxins (2)
- Mycotoxins (2)
- Nitric oxide (2)
- PUFA (2)
- Pak choi (2)
- Palmitate (2)
- Parkinson disease (2)
- Pesticides (2)
- Phenological modelling (2)
- Phenylpropanoids (2)
- Post mortem chemistry (2)
- Prediabetes (2)
- Proteasome (2)
- Protein oxidation (2)
- Protein restriction (2)
- RBP4 (2)
- Rats (2)
- Renal failure (2)
- Review (2)
- SDS PAGE (2)
- Selenium (2)
- Skeletal muscle cells (2)
- Skin nanocarrier (2)
- Skin penetration (2)
- Small for gestational age (2)
- Solanum lycopersicum (2)
- Tandem mass spectrometry (2)
- Technical enzymes (2)
- Thiomersal (2)
- Thioredoxin (2)
- Trace elements (2)
- Type 2 diabetes (2)
- Whey protein (2)
- Xylanase (2)
- Zinc homeostasis (2)
- acute kidney injury (2)
- adipogenesis (2)
- albuminuria (2)
- angiotensin receptor blockers (2)
- antioxidants (2)
- appetite (2)
- atherosclerosis (2)
- autophagy (2)
- bioavailability (2)
- biofortification (2)
- brain (2)
- calcium (2)
- cell-based assay (2)
- cells (2)
- chronic diseases (2)
- clusterin (2)
- coffee by-products (2)
- cyclooxygenase (2)
- database (2)
- diet (2)
- dietary patterns (2)
- elevated plus-maze (2)
- endothelin (2)
- fatty acid metabolism (2)
- fatty liver (2)
- fetal programming (2)
- fibrosis (2)
- food choice (2)
- gallbladder cancer (2)
- glucocorticoid receptor (2)
- glycaemic control (2)
- gut microbiota (2)
- heart (2)
- hepatic steatosis (2)
- high-sodium (2)
- hypertension (2)
- kidney (2)
- leptin (2)
- lipid metabolism (2)
- liver (2)
- liver metabolism (2)
- low birth weight (2)
- lung infection (2)
- manganese (2)
- mass spectrometry (2)
- meta-analysis (2)
- metabolomics (2)
- method comparison (2)
- mitochondrial dysfunction (2)
- mitochondrial function (2)
- model (2)
- monitoring (2)
- mortality (2)
- neurodegeneration (2)
- non-alcoholic fatty liver disease (2)
- older persons (2)
- open-field (2)
- p53 (2)
- plant volatiles (2)
- platelets (2)
- pneumonia (2)
- post-natal (2)
- pre-natal (2)
- proliferation (2)
- proteasome (2)
- protein restriction (2)
- proteomic analysis (2)
- proteostasis (2)
- rapid test kit (2)
- redox state (2)
- refinement (2)
- reliability (2)
- salt (2)
- sample preparation (2)
- selenium (2)
- soy protein (2)
- sphingomyelin (2)
- transformation products (2)
- transthyretin (2)
- type 2 (2)
- validity (2)
- vascular calcification (2)
- vegetables (2)
- weight loss (2)
- (2E)-Hexadecenal (1)
- (2E)-hexadecenal (1)
- (2E)-hexadecenoic acid (1)
- (9Z)-neoxanthin (1)
- 1-Methoxy-3-indolylmethyl glucosinolate (1)
- 1-Phenylethanol (1)
- 1-aminodecylidene bis-phosphonic acid (1)
- 1-phosphate (1)
- 11 beta-hydroxysteroid dehydrogenase 2 (1)
- 2-Phenylethanol (1)
- 20S (1)
- 25-OH vitamin D (1)
- 2D-LC-MS/MS (1)
- 2k1c renovascular hypertension (1)
- 3,4-didehydroretinol (1)
- 3,5-Dimethoxytoluene (1)
- 3D breast cell model (1)
- 3D tissue model (1)
- 5-gliadin (1)
- 7 macrophages (1)
- ACE I/D polymorphism (1)
- ACE inhibitors (1)
- ADPKD (1)
- AGE (1)
- AMD (1)
- AMPK (1)
- AOAC (1)
- APOM protein (1)
- ARPE-19 cells (1)
- ASI-3 (1)
- Abrus precatorius (1)
- Acute coronary syndrome (1)
- Acute renal failure (1)
- Adipocytes (1)
- Adult height (1)
- Advanced fetal programming hypothesis (1)
- Advanced glycation end products (1)
- Advanced glycation end-products (1)
- Advanced glycation endproducts (1)
- Aflatoxin B1 (1)
- Age (1)
- Akkermansia muciniphila (1)
- Akt pathway (1)
- Akt signaling (1)
- Akt/PKB (1)
- Alcohol dependence (1)
- Allergenic food (1)
- Allicin (1)
- Allyl isothiocyanate (1)
- Alpine metamorphism (1)
- Alveolar epithelial cells (1)
- Amaranth (1)
- Amaranthaceae (1)
- Anemia (1)
- Angiotensin converting enzyme inhibitor (1)
- Ankle-brachial index (1)
- Anorexia (1)
- Antibiotics (1)
- Antimicrobial drugs (1)
- Antioxidant capacity (1)
- Antioxidants (1)
- Anxiety (1)
- Anxiety Sensitivity Index (1)
- Aortic valve (1)
- Apgar score (1)
- Apple polyphenoloxidase (1)
- Arabica coffee (1)
- Arabica coffee beans (1)
- Arbuscularmycorrhizal fungi (1)
- Arsenic speciation (1)
- Arsenite (1)
- Arsenolipid (1)
- Arsenosugar (1)
- Aryl-hydrocarbon receptor (1)
- Asian subjects (1)
- Aspergillus (1)
- Aspirin (1)
- Assay High-resolution mass spectrometry (1)
- Assay hochauflösende Massenspektrometrie (1)
- Assays (1)
- Astrocytes (1)
- Atherosclerosis (1)
- Athletes (1)
- Augmentation (1)
- Autophagie Lysosomale System (1)
- Autotaxin (1)
- B cells (1)
- BALB/c-3T3 cells (1)
- BBsome (1)
- BIOCROSS (1)
- BMI (1)
- BMI change (1)
- BMP4 (1)
- Baked products (1)
- Bbs4 (1)
- Be-10 dating (1)
- Beef (1)
- Beryllium (1)
- Beta-amylase (1)
- Beta-lactoglobulin (1)
- BfR MEAL Study (1)
- Bilophila wadsworthia (1)
- Biocompatibility (1)
- Biological Assay (1)
- Biomarkers (1)
- Bioreactor (1)
- Biparietal diameter (1)
- Birds of prey (1)
- Blood (1)
- Blood flow resistance (1)
- Blood platelets (1)
- Blood protein adducts (1)
- Blood-cerebrospinal fluid barrier (1)
- Blood-liquor barrier (1)
- BoNT (1)
- BoNT/B uptake (1)
- Body composition (1)
- Brain development (1)
- Brassica (1)
- Brassica carinata (1)
- Brassica oleracea var. sabellica (1)
- Brassica rapa ssp. chinensis (1)
- Brassica vegetables (1)
- Brassicaceae (1)
- Brood size (1)
- Brown adipose tissue (1)
- CD, DLS (1)
- CKD (1)
- COPD (1)
- COVID 19 (1)
- CRISPR editing validation (1)
- Cachexia (1)
- Caco-2/HT-29-MTX-model (1)
- Caenorhabitis elegans (1)
- Calculated free 25-hydroxyvitamin D (1)
- Calorimetry (1)
- Cameroon (1)
- Cancer prevention (1)
- Cardiac function (1)
- Cardiac ischemia/reperfusion (1)
- Cardiac rehabilitation (1)
- Cardiovascular (1)
- Cardiovascular effects (1)
- Carotene supplementation (1)
- Case-control study (1)
- Casein (1)
- Catechin (1)
- Catechins (1)
- Cattle (1)
- Cell culture materials (1)
- Cellular bioavailability (1)
- Cellular damage response (1)
- Cellular uptake (1)
- Cellulose acetate phthalate (1)
- Chad (1)
- Chaperone (1)
- Chemotherapy resistance (1)
- Childhood nephrotic syndrome (1)
- Chlorophyllide a oxygenase (1)
- Chlorophylls (1)
- Chloroplast (1)
- Cholesterol (1)
- Chronic diseases (1)
- Chronic kidney disease (1)
- Chrysopidae (1)
- Chylomicron (1)
- Circadian rhythm (1)
- Clinical study (1)
- Clinical trials (1)
- Clostridium difficile (1)
- Coagulation (1)
- Cognition (1)
- Colitis (1)
- Collagen (1)
- Colon cancer (1)
- Colonic microbiota (1)
- Comet assay (1)
- Complications in diabetes (1)
- Connective tissue growth factor (1)
- Contaminants (1)
- Contamination (1)
- Contrast induced acute kidney injury (1)
- Control region (1)
- Core-multishell nanocarriers (1)
- Coronary angiography (1)
- Cortisol Maternal cortisol (1)
- Cortisol vertical bar metabolism (1)
- Costs (1)
- Covalent modification (1)
- Cow-side assay (1)
- Crop quality (1)
- Cross-sectional studies (1)
- Cu NP-incorporated MI-dPG coating (1)
- Curcumin (1)
- Cyp2b1 (1)
- Cystic fibrosis (1)
- Cytokines (1)
- DAF-16 (1)
- DAF-16 transcription factor (1)
- DAIH (1)
- DDP-4 inhibition (1)
- DNA adducts (1)
- DNA damage response (1)
- DNA integrity (1)
- DNA repair (1)
- DNMT inhibitor (1)
- DNMT1 (1)
- DPP-4 inhibition (1)
- DPP-4 inhibitor (1)
- DPP-IV inhibitor (1)
- DPP4 (1)
- DPP4 inhibition (1)
- Dairy biomarkers (1)
- Daucus (1)
- Decontamination (1)
- Delinquency (1)
- Demographic transitions (1)
- Dendritic cells (1)
- Dendritic core-multishell nanocarriers (1)
- Dengue (1)
- Depression (1)
- Derivatisation (1)
- Derivatization (1)
- Dermal delivery (1)
- Dermal drug delivery (1)
- Determinants (1)
- Developmental programming (1)
- Diabetes incidence (1)
- Diabetic cardiomyopathy (1)
- Diacylglycerol (DAG) (1)
- Diagnostic (1)
- Diallyl disulfide (1)
- Diarrhoea (1)
- Dichlorofluorescein assay (1)
- Dietary compliance (1)
- Dietary fat composition (1)
- Dietary fat replacement (1)
- Dipeptidyl peptidase 4 inhibitor (1)
- Dipeptidyl peptidase IV (1)
- Dipeptidyl peptidase-4 inhibition (1)
- Dipeptidylpeptidase-4 (1)
- Disease (1)
- Distal tubules (1)
- Dog growth (1)
- Dogs (1)
- Dolichol lipids (1)
- Domestic cat (1)
- Domestic cooking (1)
- Donors (1)
- Dopaminergic neurons (1)
- Dopaminergic system (1)
- Drug delivery systems (1)
- Drug metabolism (1)
- E-2 (1)
- EBI3 (1)
- EDC (1)
- EPIC-Potsdam study (1)
- ER stress (1)
- ER-stress (1)
- ETA (1)
- ETB (1)
- ETB receptor-deficient mouse (1)
- Edible insects (1)
- Eicosanoid (1)
- Electrochemistry (1)
- Electron paramagnetic resonance spectroscopy (1)
- Elektrochemie (1)
- Elemental blood serum concentration (1)
- Emulsifying properties (1)
- Enantio-selective reduction (1)
- Endocrine disruption (1)
- Endodormancy (1)
- Endosomal sorting (1)
- Endothelial dysfunction (1)
- Endothelial nitric oxide synthase (1)
- Endothelin receptor antagonists (1)
- Endothelin-1 transgenic mice (1)
- Energy expenditure (1)
- Energy intake (1)
- Energy metabolism (1)
- Energy requirement (1)
- Enteric polymer (1)
- Environmental (1)
- Epidemiologie (1)
- Epigenetic (1)
- Equine metabolic syndrome (1)
- Equines (1)
- Ernährungsmuster (1)
- Erosion kinetics (1)
- Et-1 (1)
- Ethyl cellulose (1)
- Eudragit (R) (1)
- Eudragit (R) RS (1)
- Eudragit L 100 (1)
- Euphorbia mauritanica (1)
- Euphorbiaceae (1)
- Evaluation tool (1)
- Excretion (1)
- Exercise tests (1)
- Experimental autoimmune encephalomyelitis (EAE) (1)
- Extraction (1)
- FASN (1)
- FISH (1)
- Fabaceae (1)
- Factor-Xa (1)
- Faecal bacteria (1)
- Fast and slow fibers (1)
- Fat-free mass (1)
- Fattening pigs (1)
- Fatty acid hydroperoxides (1)
- Ferritin (1)
- Fetal development (1)
- Fettgewebe (1)
- Fibroblast growth factor 21 (1)
- Fibrosis (1)
- Fingolimod (1)
- Firefly luciferase inhibition (1)
- First trimester (1)
- Flavonoid (1)
- Flavonoid glycosides (1)
- Flavonoids (1)
- Floral scent compound (1)
- Flowering (1)
- Fluorescence lifetime imaging microscopy (1)
- Fluorescence screening (1)
- Foal (1)
- Foaming properties (1)
- Food (1)
- Food analysis (1)
- Food authentication (1)
- Food choice (1)
- Food composition (1)
- Food labelling (1)
- Food safety (1)
- Food-exchange model (1)
- Forensic science (1)
- Forster resonance energy transfer (FRET) (1)
- Frailty criteria (1)
- Free radicals (1)
- Free vitamin D (1)
- Freeze-fracturing (1)
- Fruits (1)
- Functionality (1)
- Furosemide (1)
- GADD45A and GADD45G (1)
- GC gene (1)
- GC-MS (1)
- GC-globulin (1)
- GLP-1 (1)
- GLUT1 XbaI gene polymorphism (1)
- GPx activity (1)
- Garlic (1)
- Gastrointestinal tract (1)
- Gene expression (1)
- Gene polymorphism (1)
- Genetics (1)
- Genetik (1)
- Geriatric patients (1)
- Gestational diabetes (1)
- Gliadin and glutenin fractions (1)
- Global (1)
- Global DNA methylation (1)
- Glp1r(-/-) mice (1)
- Glucose homeostasis (1)
- Glucose intolerance (1)
- Glucose tolerance (1)
- Glucosinolate breakdown product (1)
- Glukoseintoleranz (1)
- Glutathione (1)
- Gluten (1)
- Glycation (1)
- Glycemia (1)
- Glycerophospholipids (1)
- Gut microbiota (1)
- HAMP (1)
- HNRNPA1 (1)
- HOG (1)
- HOMA (1)
- HPLC-ESI-QTOF (1)
- HPLC/HR-ESMS (1)
- HPLC/ICPMS (1)
- HPMCP (1)
- HSD11B2[CA]n polymorphism (1)
- HSP70 (1)
- HaCaT cells (1)
- Head circumference (1)
- Health care expenditure (1)
- Health-promoting compounds (1)
- Heart failure (1)
- Heart weight (1)
- Heat aggregation (1)
- Heat shock protein 90 (1)
- Heat shock proteins (1)
- Heavy metals (1)
- Heme (1)
- Hemoglobin (1)
- Hepatic insulin resistance (1)
- Hepatic stellate cells (1)
- Hepatotoxicity (1)
- Herd size (1)
- Herd type (1)
- Heterogeneity (1)
- High pressure - low temperature treatments (1)
- High resolution microscopy (1)
- Honey (1)
- Hormones (1)
- Horse (1)
- Host-plant suitability (1)
- Human (1)
- Human differentiated neurons (1)
- Human nutritional intervention (1)
- Hydroxycinnamic acids (1)
- Hyperglycaemia (1)
- Hypermethylation (1)
- Hyphenated techniques (1)
- Hypoxia (1)
- ICP-MS (1)
- ICP-QQQ-MS (1)
- IDH1 (1)
- IGF-1 (1)
- IgE (1)
- Imiquimod (1)
- Inactivation (1)
- Indigenous African leafy vegetables (1)
- Indole (1)
- Inductively (1)
- Inductively coupled plasma mass spectrometry (1)
- Infarct size (1)
- Inflammaging (1)
- Inflammatory bowel disease (1)
- Inflammatory skin disease (1)
- Influenza virus (1)
- Inhalation (1)
- Inorganic mercury (1)
- Insulin signaling (1)
- Insulin signalling (1)
- Insulinsekretion (1)
- Intergenerational effects (1)
- Intestinal absorption (1)
- Intraperitoneal administration (1)
- Iodization (1)
- Iron deficiency anemia (1)
- Ischemia/reperfusion (1)
- Isoprostane (1)
- Isotope ratios (1)
- Isotope-dilution (1)
- Isotope-dilution analysis (1)
- Jurkat cells (1)
- Kalzium (1)
- Kidney weight (1)
- Kosakonia radicincitans (1)
- Kynurenine (1)
- LC (1)
- LC-MRM-MS (1)
- LC-MS (1)
- LC-MS-MS (1)
- LC/HRMS (1)
- LC/MS/MS; Quantification of allergenic plant traces (1)
- LEDs (1)
- LPA(3) receptor subtype (1)
- Langerhans cells (1)
- Leg length (1)
- Legume (1)
- Lemna paucicostata (1)
- Life science (1)
- Light quality (1)
- Lipase (1)
- Lipid (1)
- Lipid droplet proteome (1)
- Lipid metabolism (1)
- Lipolysis (1)
- Liquid chromatography-tandem mass spectrometry (1)
- Liquid-liquid extraction (1)
- Lithiumion battery (LIB) (1)
- Liver fat (1)
- Liver fibrosis (1)
- Liver injury (1)
- Long term health (1)
- Long-term cellular toxicity (1)
- Loop diuretics (1)
- Low birth weight (1)
- Low lean mass (1)
- Low muscle mass (1)
- Lu-Hf geochronology (1)
- Lupin (1)
- Lutein (1)
- Lutein ester (1)
- Lymphocytes (1)
- Lysophosphatidic acid (1)
- Lysophosphatidylcholines (1)
- M1/M2 differentiation (1)
- MALDI-TOF/MS (1)
- MCT oil (1)
- MMF (1)
- MRSA (1)
- MS quantification of leguminous additives (1)
- MSCs (1)
- Macrovascular (1)
- Major adverse kidney event (1)
- Mangan (1)
- Manganese . C. elegans (1)
- Manganism (1)
- Marker (1)
- Mauritanicain (1)
- Measured free 25-hydroxyvitamin D (1)
- Meat peptide biomarker (1)
- Membrane (1)
- Menderes Massif (1)
- Mesoangioblasts (1)
- Meta-analyses (1)
- Metabolically benign (1)
- Metabolism (1)
- Metabolom (1)
- Metabolome analysis (1)
- Metabolomics (1)
- Metals (1)
- Methicillin resistant Staphylococcus aureus (1)
- Method comparison (1)
- Methylation (1)
- Methylglyoxal (1)
- MiSpEx* (1)
- Mice (1)
- Micellar caseins (1)
- Microbial degradation (1)
- Microbiome (1)
- Microdialysis (1)
- Microelements (1)
- Microsomal (1)
- Microvascular complications (1)
- Migration (1)
- Mikrosomal (1)
- Mitochondrial respiration (1)
- Mitohormesis (1)
- Mixed lymphocyte culture (MLC) (1)
- Molecular structure (1)
- Monocyte (1)
- Moringa oleifera (1)
- Morphogenesis (1)
- Mortality (1)
- Motor coordination (1)
- Multi-Methods (1)
- Multi-method (1)
- Multi-mycotoxin analysis (1)
- Multiple herbivory (1)
- Multiple sclerosis (1)
- Multiplex platforms (1)
- Mycobacterium tuberculosis (1)
- Myoblasts (1)
- Myocardial infarction (1)
- Myocardial ischemia (1)
- Myogenic differentiation (1)
- Myoglobin (1)
- Myzus persicae (1)
- NAFLD/MAFLD (1)
- NF-?B (1)
- NF-kappa B (1)
- NF1 (1)
- NMR-based metabolomics (1)
- NR3C1 gene (1)
- Nanoparticle uptake (1)
- Nanoparticles (1)
- Nanotoxicology (1)
- Natriuretic peptides (1)
- Neisseria gonorrhoeae (1)
- Neoglucobrassicin (1)
- Neurodegeneration (1)
- Neurodevelopmental toxicity (1)
- Neurons (1)
- Neutral lipids (1)
- Neutrophils (1)
- New World camelids (1)
- Nif2 (1)
- Non-esterified fatty acids (NEFA) (1)
- Nordic diet (1)
- Nuclear receptor (1)
- NutriAct family study (1)
- Nutritional counseling (1)
- Nährstoffe (1)
- OCFA (1)
- Occurrence data (1)
- Ocular delivery (1)
- Odorant compounds (1)
- Offending (1)
- Offspring (1)
- Ontogenetic development (1)
- Ontogeny (1)
- Organic and conventional type of production (1)
- Organic arsenic (1)
- Organic carbonates (1)
- Organic mercury (1)
- Other livestock (1)
- Outcome (1)
- Oxidized proteins (1)
- Oxylipin (1)
- Oxylipins (1)
- PCR-DHPLC (1)
- PCaaC38:6 (1)
- PGC1 alpha (1)
- PKM2 (1)
- PTH (1)
- Pancreatic cells (1)
- Pannexin 1 (1)
- Parenthood (1)
- Paternal exposure (1)
- Paternal, maternal, sex differences (1)
- Pea flour (1)
- Pea protein isolate (1)
- Peptides (1)
- Permeability (1)
- Peroxidatic and resolving cysteine (1)
- Peroxiredoxin (1)
- Peroxynitrite (1)
- Personalised medicine (1)
- Pest infestation (1)
- Pest-pest interaction (1)
- Pharbitis nil cv. Violet (1)
- Pharmacokinetics (1)
- Phenol-amino-adducts (1)
- Phosphatidylcholines (1)
- Phosphatidylinositols (1)
- Phospholipids (1)
- Photosynthesis (1)
- Physicochemical properties (1)
- Pig (1)
- PlGF (1)
- Plackett–Burman design (1)
- Plant allergen (soy, sesame, lupine) (1)
- Plant authentication (1)
- Plant growth promoting bacteria (1)
- Plasma (1)
- Plasma concentration (1)
- Plasmalogens (1)
- Platelets (1)
- Polymeric nanoparticle (1)
- Polymeric nanoparticles (1)
- Polyphenols (1)
- Polyubiquitination (1)
- Pooling analysis (1)
- Post-translational modifications (1)
- Post-translational protein modification (1)
- Postharvest processing (1)
- Precision medicine (1)
- Precision prognostics (1)
- Preeclampsia (1)
- Preinterventional biomarker (1)
- Presystemic metabolism (1)
- Preterm birth (1)
- Preterm delivery (1)
- Procyanidins (1)
- Proliferation (1)
- Prostaglandin receptor EP4 (1)
- Proteasomal system (1)
- Proteasome and lysosome (1)
- Protein aggregates (1)
- Protein functionality and modification (1)
- Proteolysis (1)
- Proteome (1)
- Proteostase (1)
- Proteostasis (1)
- Pseudomonas aeruginosa (1)
- Psoriasis (1)
- Pulmonary arterial hypertension (1)
- Pulse wave velocity (1)
- Purification (1)
- Pyrrolizidine alkaloids (1)
- QTL (1)
- Quality appraisal (1)
- Quantification of peptides (1)
- RAW 264 (1)
- RNAseq (1)
- ROS (1)
- RRR (1)
- Radiocontrast media-induced nephropathy (1)
- Raman spectroscopy (1)
- Redox control (1)
- Redox homeostasis (1)
- Redox regulation (1)
- Reference intervals (1)
- Regionality (1)
- Regulatory T cells (Treg) (1)
- Relaxin (1)
- Reliability (1)
- Renin-angiotensin system (1)
- Renin-angiotensin-aldosterone system (1)
- Resistant starch (1)
- Reticulocytes (1)
- Retinoblastoma (1)
- Retinol (1)
- Risk (1)
- Risk factor (1)
- Risk prediction (1)
- Root exudates (1)
- Rosa x level (1)
- Rye (1)
- S-XRF (1)
- S1P receptors (1)
- S1P(3) receptor (1)
- SCID mice (1)
- SEC-HPLC (1)
- SFA (1)
- SGK-1 (1)
- SIMS techniques (1)
- SNARE proteins (1)
- SREBP-1c (1)
- ST-1071 (1)
- ST-1893 (1)
- ST-1894 (1)
- ST-968 (1)
- SU5416 (1)
- SVM (1)
- Saccharomyces boulardii (1)
- Safety (1)
- Sarcopenia (1)
- Se (1)
- Se-methylselenoneine (1)
- Seafood (1)
- Seasonality (1)
- Secondary metabolites (1)
- Selenoneine (1)
- Selenosugar 1 (1)
- Senescence (1)
- Serine and trypsin protease (1)
- Serotonin (1)
- Sex ratio at birth (1)
- Sexual dimorphism (1)
- Shan He Jian Fei Granules (SHJFG) (1)
- Short chain dehydrogenase (1)
- Short stature (1)
- Side effects (1)
- Signal transduction (1)
- Signaling pathways (1)
- Single nucleotide polymorphism (1)
- Skelettmuskelalterung (1)
- Skin (1)
- Skin barrier disruption (1)
- Skin model (1)
- Slatted floor (1)
- Small molecules (1)
- Small selenium species (1)
- Smooth muscle cells (1)
- Smpd1 (1)
- Solanum scabrum (1)
- Speciation (1)
- Species differences (1)
- Spectrophotometry (1)
- Spelt (1)
- Sphingomyelin (1)
- Sphingosine 1-phosphate (S1P) (1)
- Sphingosine 1phosphate (1)
- Sphingosine kinase-1 (1)
- Sphingosine-1-phosphate lyase (1)
- Spirulina (1)
- Spurenelement (1)
- Stillbirth (1)
- Stoffwechsel (1)
- Stress response (1)
- Stroke (1)
- Stromal cell-derived factor-1 (1)
- Structural changes (1)
- Study protocol (1)
- Sucrose (1)
- Sulfonate (1)
- Sulfoquinovose (1)
- Susceptibility-genes (1)
- Suszeptibilitätsgene (1)
- Swine (1)
- T helper 17 cells (1)
- TAVI (1)
- TEAC (1)
- TEM (1)
- TET (1)
- TGF-beta (1)
- TGF-beta 1 (1)
- TLR signaling (1)
- TNF alpha (1)
- TRPV5 (1)
- TRPV6 (1)
- TTR (1)
- Tagetes (1)
- Taurocholate (1)
- Tea leaves (1)
- Technofunctional properties (1)
- Tenebrio molitor larvae (1)
- Testicle (1)
- Tetranychus urticae (1)
- Th17 (1)
- Thai population (1)
- Thermal and nonthermal treatment (1)
- Thermal processing (1)
- Thin layer chromatography (1)
- Thio-arsenosugar-glycerol (1)
- Thio-dimethylarsinic acid (1)
- Thiol (1)
- Thiol-dependent peroxidase (1)
- Thioredoxin reductase (1)
- Three phase partitioning (1)
- Thrifty phenotype (1)
- Thyroid hormone (1)
- Tierarzneimittel (1)
- ToF-SIMS (1)
- ToF-SIMS imaging (1)
- Tocotrienols (1)
- Total arsenic (1)
- Total diet study (1)
- Toxicokinetics (1)
- Trans-epoxy-fatty acid (1)
- Transactivation assay (1)
- Transcatheter Aortic Valve Implantation (1)
- Transcriptomics (1)
- Transformation product (1)
- Transformationsprodukt (1)
- Transforming growth factor beta (1)
- Transkriptom (1)
- Transmembrane asymmetry (1)
- Transplantation (1)
- Triglyceride secretion (1)
- Trunk length (1)
- Tumor necrosis factor alpha (1)
- Tween40 micelles (1)
- Twister (TM) (1)
- Typ-2-Diabetes mellitus (1)
- UDP-glucuronosyltransferase (1)
- UV light (1)
- Ubiquitin Proteasom System (1)
- Ulcerative colitis (1)
- Umbilical artery Doppler (1)
- Umbrella review (1)
- Uncoupling proteins (1)
- Unprepared and (1)
- Urinary ET-1 (1)
- Urine excretion (1)
- Uruguay River (1)
- VGCC (1)
- Validation (1)
- Vascular stiffness (1)
- Vegan (1)
- Very low birth weight infant (1)
- Veterinary drugs (1)
- Vineatrol (R) 30 (1)
- Vitamin A supplementation (1)
- Vitamin C (1)
- Vitamin D (1)
- Vitamin D binding protein (1)
- Vitamin D deficiency (1)
- Vitamin D insufficiency (1)
- Vitamin D-binding protein (1)
- Vitamin K (1)
- Vitellogenin (1)
- Volatile compound (1)
- WAT (1)
- Warburg effect (1)
- Water and salt retention (1)
- Wheat (1)
- Whey proteins (1)
- World Cancer Research Fund/American Institute for Cancer Research Recommendations (1)
- Xenobesity (1)
- Y:X chromosome ratio (1)
- YB-1 (1)
- Yolk (1)
- Zink (1)
- Zoonoses (1)
- [N-15]Anthranilic acid (1)
- [N-15]Indole (1)
- a-tocopherol (1)
- accretionary wedge (1)
- accumulation (1)
- acetate (1)
- acid ceramidase (1)
- activated carbon (1)
- adipose tissue dysregulation (1)
- adiposity (1)
- aflatoxin B1 (1)
- age (1)
- ageing (1)
- air pollution (1)
- air-dried (1)
- air-fried (1)
- all-cause mortality (1)
- allometric model (1)
- alpha-SMA (1)
- alpha-Tocopherol (1)
- alpha-tocopherol (1)
- amaranth (1)
- amino acid score (1)
- amino acids (1)
- amylase activity (1)
- analytical methods (1)
- angiotensin (1-7) (1)
- angiotensin II (1)
- anorexia (1)
- anthropometric measures (1)
- anti-genotoxicity (1)
- anti-inflammatory nutrition (1)
- anti-oxidant activity (1)
- anti-oxidative capacity (1)
- antibacterial effect (1)
- anticancer (1)
- antidiabetic drug (1)
- antioxidant activity (1)
- antioxidant defense systems (1)
- antioxidant potential (1)
- antioxidative phenolic ingredients (1)
- anxiety sensitivity (1)
- anxiety-like behavior (1)
- aphids (1)
- apoptosis (1)
- arabinoxylan (1)
- aroma quality (1)
- arsenic (1)
- arsenolipids (1)
- artificial (1)
- ascorbate (1)
- asymmetric dimethylarginine (ADMA) (1)
- atmospheric deposition (1)
- auditory neurons (1)
- autofluorescence (1)
- autoimmunity (1)
- autophagy flux (1)
- autophagy lysosomal system (1)
- base excision repair (incision activity) (1)
- batch process (1)
- beta-Lactoglobulin (1)
- beta-carotene (1)
- beta-carotene hydroxylase (1)
- beta-cell (1)
- beta-cell loss (1)
- beta-cells (1)
- binding (1)
- bioactive peptides (1)
- biological pest control (1)
- biomarker (1)
- biomarkers of renal failure (1)
- birds of prey (1)
- birth weight (1)
- birthweight (1)
- bisphosphonates (1)
- bladder cancer cells (1)
- blood banking (1)
- blood biomarker (1)
- blood pressure (1)
- body weight gain (1)
- bone (1)
- bone mineral density (1)
- botulinum toxin (1)
- bound phenolic compounds (1)
- brain insulin signaling (1)
- broiler chicks (1)
- browning (1)
- c. elegans (1)
- caenorhabditis elegans (1)
- caffeic acid derivatives (1)
- calbindin D9k (1)
- calcination (1)
- calcitriol (1)
- calcium transport (1)
- cancer cachexia (1)
- cancer cells (1)
- cancer chemoprevention (1)
- cancer epidemiology (1)
- cancer stem cells (1)
- canine osteoarthritis (1)
- capillary blood (1)
- carbon sequestration (1)
- cardiac progenitor migration and differentiation (1)
- cardiometabolic diseases (1)
- cardiovascular diseases (1)
- carota L (1)
- carotene (1)
- carotenoid (1)
- carotenoid biosynthesis (1)
- carotenoids bioavailability (1)
- cell cycle (1)
- cell migration (1)
- cell transformation assay (1)
- cell wall deficient mutant (1)
- cellular bioimaging (1)
- cellular uptake (1)
- cerami-des (1)
- ceramides (1)
- cereal meals (1)
- chaperones (1)
- chemokines (1)
- chick embryo (1)
- children (1)
- chimpanzee (1)
- chlorophylls (1)
- chronic disease (1)
- chronic fatigue (1)
- chronic psychosocial stress (1)
- chronic subordinate colony housing (CSC) (1)
- cilium (1)
- circadian clock (1)
- circulation (1)
- classification (1)
- click chemistry (1)
- clinical prediction rule (1)
- clinical sample (1)
- clinical studies (1)
- clinical trial (1)
- cocoa processing (1)
- cocoa proteins (1)
- coenzyme-a (1)
- coffee processing (1)
- cold atmospheric pressure plasma (1)
- collagen I (1)
- color (1)
- color preference (1)
- color vision (1)
- colorectal neoplasm (1)
- colostrum (1)
- comparison (1)
- complication (1)
- complications (1)
- constitutive androstane receptor (1)
- construct validity (1)
- continuous process (1)
- contrast-induced nephropathy (1)
- copper (1)
- copper-related disorders (1)
- copy number analyses (1)
- core (1)
- coronary heart disease (1)
- cortisol (1)
- cost-effectiveness analysis (1)
- coupled plasma mass spectrometry (1)
- cow-side assay (1)
- crop (1)
- cysteine alkylation (1)
- cystic fibrosis (1)
- cytokine (1)
- cytotoxicity (1)
- d-Loop (1)
- decision tree (1)
- decitabine (1)
- deep-fried (1)
- dendritic cell (1)
- dendritic polyglycerol (1)
- depression (1)
- depressive-like behavior (1)
- design of experiment (1)
- determinants (1)
- diabetes mellitus (1)
- diatoms (1)
- diet score (1)
- diet selection (1)
- diet-disease association (1)
- dietary citric acid (1)
- dietary fibre (1)
- dietary guidelines (1)
- dietary restriction (1)
- differentiation (1)
- digestive enzymes quantification (1)
- disproportional intrauterine growth retardation (1)
- distal convoluted tubule (1)
- distress (1)
- diurnal rhythm (1)
- dog (1)
- dogs (1)
- domestic cooking (1)
- dormancy (1)
- drug delivery (1)
- drug design (1)
- drug metabolism (1)
- drug-resistant bacteria (1)
- eNOS (1)
- eating (1)
- echocardiography (1)
- egg yolk (1)
- eicosanoids (1)
- emotionality (1)
- endocrine disruption (1)
- endothelin-converting enzyme (1)
- endurance exercise (1)
- energy expenditure (1)
- energy homeostasis (1)
- energy-metabolism (1)
- environmental DNA (1)
- enzyme assays (1)
- enzyme induction (1)
- enzymology (1)
- equine (1)
- erythropoiesis (1)
- etiology (1)
- experimental antigen-induced encephalomyelitis (1)
- exposome (1)
- exposome‐ wide association study (1)
- expression (1)
- extinction (1)
- extra-cellular matrix (1)
- extraction (1)
- extraction and characterization methods (1)
- factor structure (1)
- fasting blood glucose (1)
- fat-soluble vitamin (1)
- fatigue (1)
- fatigue reduction diet (1)
- fatty acid synthesis (1)
- fatty pancreas (1)
- feeding (1)
- fermentation (1)
- fermentation-related enzymes (1)
- fetal origins hypothesis (1)
- fetal programing (1)
- fetal sex (1)
- fiber (1)
- filter paper (1)
- fingolimod (1)
- first trimester (1)
- flavonoids (1)
- flower buds (1)
- fluvial terraces (1)
- foal (1)
- food frequency questionnaire (1)
- food groups (1)
- food safety (1)
- foot and mouth disease (HFMD) (1)
- force-field (1)
- forebrain (1)
- fortification (1)
- fractionation (1)
- free radicals (1)
- fruit (1)
- fruit metabolites (1)
- functional inhibitors of acid sphin-gomyelinase (1)
- functional properties (1)
- garnet (1)
- gene expression (1)
- gene-lifestyle interaction (1)
- genetic variants (1)
- genetically modified BoNT (1)
- genetics (1)
- genomics (1)
- gestational diabetes mellitus (GDM) (1)
- girths and breadths (1)
- glasswort (1)
- gliptins (1)
- glomerular arterioles (1)
- glomerular filtration rate (1)
- glucose intolerance (1)
- glucosinolates (1)
- glutathione (1)
- glycemic control (1)
- glycemic control during pregnancy (1)
- glycogen synthase kinase-3 (1)
- goblet cells (1)
- gold nanostars (1)
- green tea phenols (1)
- growth behavior (1)
- growth restriction (1)
- gwas (1)
- haemodialysis (1)
- hallervorden-spatz-syndrome (1)
- halophytes (1)
- hand (1)
- haplotype (1)
- healthy subjects (1)
- heart tube (1)
- heart-type fatty acid binding protein (1)
- heath potentials (1)
- hepatic impairment (1)
- hepatocellular carcinoma (1)
- heptadecanoic acid (C17:0) (1)
- high salt (1)
- high-density lipoprotein (HDL) (1)
- high-fat diet (1)
- high-resolution imaging (1)
- hippocampus (1)
- homeostasis (1)
- homologous recombination deficiency (1)
- homology-directed repair (1)
- hsp-70 (1)
- human excised skin (1)
- human follicular fluid (1)
- human health (1)
- human liver microsomes (1)
- human milk (1)
- hydrolysis (1)
- hyperglycemia (1)
- hypotension (1)
- hypoxic pulmonary vasoconstriction (1)
- hypoxische pulmonale Vasokonstriktion (1)
- immune system (1)
- immune-inflammatory biomarkers (1)
- immunoblot (1)
- immunology (1)
- immunomodulator (1)
- impaired glucose tolerance (1)
- in situ chemical reduction (1)
- in vitro intestinal model (1)
- in vivo (1)
- incident type 2 diabetes (1)
- index (1)
- indigenous leafy vegetables (1)
- infection (1)
- inhibitory cytokines (1)
- insect proteins (1)
- insulin signaling (1)
- insulin signalling (1)
- insulin-resistance (1)
- integrated stress response (1)
- integrins (1)
- intercropping (1)
- interleukin-35 (1)
- interleukin-8 (1)
- interventions (1)
- intestinal inflammation (1)
- intestinal model (1)
- intestinal mucins (1)
- intestinal zinc resorption (1)
- intrauterine (1)
- intrauterine fetal growth (1)
- inulin (1)
- invasion (1)
- involuntary weight loss (1)
- iodine (1)
- ion chromatography (1)
- ion quantification (1)
- ion-exchange chromatography (1)
- ionophore antibiotics (1)
- ischemia reperfusion injury (1)
- isothiocyanate (1)
- kale (1)
- keratinocytes (1)
- kidney dysfunction (1)
- kidney injury molecule 1 (1)
- kidney transplantation (1)
- kupffer cells (1)
- lactobacillus (1)
- lake sediments (1)
- laminitis (1)
- land-based aquaculture (1)
- langsame und schnelle Fasertypen (1)
- large for gestational age fetus (LGA) (1)
- large sample size studies (1)
- later health (1)
- latex (1)
- legumes (1)
- leucine (1)
- leukocyte-endothelial interaction (1)
- life-span (1)
- lifestyle (1)
- lifestyle risk reduction (1)
- limb lengths (1)
- lineage commitment (1)
- lipid (1)
- lipid analysis (1)
- lipid peroxidation (1)
- liposomes (1)
- litter decomposition (1)
- liver disease (1)
- liver fibrosis (1)
- liver regeneration (1)
- liver toxicity (1)
- loci (1)
- long chain base (1)
- longitudinal analysis (1)
- low birth weight (LBW) (1)
- low temperature (1)
- lower nephron (1)
- lower respiratory tract infections (LRTIs) (1)
- lung cancer (1)
- lung inflammation (1)
- lutein ester (1)
- lymphoma (1)
- lymphopenia (1)
- lysosomal hydrolases (1)
- lysosome (1)
- mPGES (1)
- machine learning (1)
- macroarray (1)
- macrophage (1)
- macrophages (1)
- maintenance of genomic integrity (1)
- mare (1)
- mass index (1)
- matrix metalloproteinases (1)
- maturity (1)
- meal timing (1)
- mealworm (1)
- measles virus (1)
- melatonin (1)
- membrane analysis (1)
- membrane fusion (1)
- membrane lipids (1)
- membrane-lipid therapy (1)
- menadione (1)
- metabolic disorders (1)
- metabolic response (1)
- metabolic stress (1)
- methionine restriction (1)
- method development (1)
- method validation (1)
- methyl jasmonate (1)
- miRNAs (1)
- mice lacking (1)
- microbial mining (1)
- microbiomics (1)
- microcomputed tomography (1)
- micronutrient deficiencies (1)
- micronutrients (1)
- microorganisms (1)
- microparticle (1)
- microplastics (1)
- microscope (1)
- microwave assisted digestion (1)
- middle adulthood (1)
- migration (1)
- mitochondria (1)
- mitochondria homeostasis (1)
- mitochondria, (1)
- mixtures (1)
- mobility-mass spectrometry (1)
- molecular dynamics (1)
- molecular modeling (1)
- molecular pathways (1)
- monensin (1)
- morpholino analogues of fingolimod (1)
- mouse models (1)
- moxidectin (1)
- mtDNA (1)
- mucus layer (1)
- multiple sclerosis (1)
- multiple-pest infestation (1)
- muscarinic acetylcholine receptor (1)
- muscle atrophy (1)
- muscle fibre composition (1)
- muscle fibre type (1)
- muscle metabolism (1)
- muscle wasting (1)
- myalgic encephalomyelitis (1)
- myocardial infarction (1)
- myopathy (1)
- n-acetyl-cysteine (1)
- nanogels (1)
- nanoparticles (1)
- nanotoxicology (1)
- narrow-banded UVB (1)
- native American ancestry (1)
- nephrin (1)
- network (1)
- neurodegenerative diseases (1)
- neurofibromatosis (1)
- neurotoxicity (1)
- neurotoxins (1)
- neutral endopeptidase (1)
- neutrophil gelatinase-associated lipocalin (1)
- new analysis method (1)
- nitric oxide (1)
- nomadic pastoralist (1)
- non-alcoholic fatty liver disease (NAFLD) (1)
- non-alcoholic steatohepatitis (1)
- nonalcoholic steatohepatthis (1)
- nonlinear microscopy (1)
- nut allergenic proteins (1)
- nutrient transport (1)
- nutrients (1)
- nutrition security (1)
- nutritional characteristics (1)
- nutritional factors (1)
- nutritional supplements (1)
- nuts (1)
- offspring (1)
- old adults (1)
- omega-3 fatty acids (1)
- one dot two development signals (ODTDS) dot blot (1)
- operant behavior (1)
- orangutan (1)
- organ failure (1)
- organic compounds adsorption (1)
- orphan crops (1)
- osteoblast (1)
- osteopontin (1)
- osteoporosis (1)
- osterix (1)
- outcome (1)
- ovarian cancer (1)
- overweight (1)
- p-AKT (1)
- p-mTOR (1)
- pH-sensitive nanoparticle (1)
- pH-sensitive nanoparticles (1)
- palm oil (1)
- parchment (1)
- particle characterization (1)
- paternal programming (1)
- patterns (1)
- pea (1)
- pentadecanoic acid (C15:0) (1)
- peptide (1)
- peptide biomarkers (1)
- peptides markers (1)
- performance (1)
- perturbation (1)
- phagocytosis (1)
- phenol nitration (1)
- phenol oxidation (1)
- phenolics (1)
- phosphorus (1)
- photochemistry (1)
- photosynthesis (1)
- photothermal therapy (1)
- phthalates (1)
- physical activity (1)
- phytochemicals (1)
- pink1 (1)
- placenta (1)
- plant growth-promoting bacteria (1)
- plant phenolic compounds (1)
- plant protease (1)
- plasma measurements (1)
- plasma process indicators (1)
- pollution (1)
- poly(ADP-ribosyl)ation (1)
- polycystic kidney disease (1)
- polycystic ovary syndrome (1)
- polyenoic fatty acids (1)
- polymorphism (1)
- population-specific risk marker (1)
- positional cloning (1)
- post-hospital syndrome (1)
- post-menopausal Thai women (1)
- postprandial response (1)
- postprandial study (1)
- potassium iodate (1)
- prebiotics (1)
- prediction (1)
- pregnancy induced diabetes (1)
- pregnane X-receptor (1)
- prepared foods (1)
- presystemic metabolism (1)
- preterm delivery (1)
- primary immunodeficiencies (1)
- priming effect (1)
- principal component analysis (1)
- proinsulin (1)
- propionate (1)
- prospective study (1)
- prostaglandin E2 (1)
- prostaglandin receptor (1)
- prostaglandins (1)
- protein derivatization (1)
- protein digestibility (1)
- protein extraction (1)
- protein microheterogeneity (1)
- protein modification (1)
- protein pattern (1)
- protein quantification (1)
- protein-phenol binding (1)
- protein-phenol interactions (1)
- proteome (1)
- proteomics (1)
- proteomix analysis (1)
- provitamin A (1)
- pulmonalarterielle glatte Muskelzellen (1)
- pulmonary artery smooth muscle cells (1)
- purification (1)
- qPCR-based gene expression screening (1)
- quality control (1)
- ramipril (1)
- randomized controlled intervention study (1)
- rapeseed protein (1)
- rapid detection method (1)
- rat (1)
- rat hepatocytes (1)
- reactive oxygen and nitrogen species (1)
- reactive oxygen species (1)
- red meat (1)
- redox homeostasis (1)
- redox-metabolites (1)
- reducing agents (1)
- reflection spectroscopy (1)
- regional diets (1)
- regulatory T cells (1)
- regulatory monitoring (1)
- relative quantification (1)
- reliability; (1)
- renal disease (1)
- renal dysfunction (1)
- renal function (1)
- renal haemodynamics (1)
- repeated measures design (1)
- repetitive elements (1)
- replacement (1)
- replication (1)
- reproducibility (1)
- resveratrol (1)
- resveratrol oligomers (1)
- retinoic acid (1)
- retinol (ROH) (1)
- retinol binding protein 4 (1)
- retinol-binding protein (1)
- retinyl esters (1)
- retinyl palmitate (1)
- reversed-phase chromatography (1)
- risk (1)
- risk factors (1)
- risk score (1)
- ruminants (1)
- s-glutathionylation (1)
- sFlt-1 (1)
- safety efficacy (1)
- saline agriculture (1)
- salinomycin (1)
- saliva (1)
- saliva proteins (1)
- salivary proteins (1)
- salmon fish (1)
- salt composition (1)
- sarcopenia (1)
- scores (1)
- scrub typhus (1)
- seawater (1)
- secondary plant metabolites (1)
- seeds (1)
- selenite (1)
- selenoneine (1)
- selenoprotein P (1)
- selenoproteins (1)
- sepsis (1)
- serine palmitoyltransferase (1)
- serine protease (1)
- serum (1)
- serum amyloid A (SAA) (1)
- serum retinol binding protein (RBP4) (1)
- sex (1)
- shortening rate (1)
- signal transduction (1)
- single nucleotide polymorphism (1)
- single-cell analysis (1)
- size (1)
- skeletal muscle (1)
- skeletal muscle aging (1)
- skin (1)
- skin penetration (1)
- slow and fast fiber types (1)
- smartphone (1)
- sodium (1)
- sorghum (1)
- soy (1)
- spectrophotometry (1)
- spent coffee grounds (1)
- spermatogenesis (1)
- sphingolipid de novo synthesis (1)
- sphingolipid metabolism (1)
- sphingomyelin phosphodiesterase 1 (1)
- sphingosine kinase (1)
- sphingosine kinase-1 (1)
- sphingosine kinases (1)
- sphingosine-1-phosphate (1)
- sphingosine-1-phosphate (S1P) (1)
- spider mites (1)
- stable-isotope labeling (1)
- status markers (1)
- stomach model (1)
- storage (1)
- stroke (1)
- suPAR (1)
- succession (1)
- sudden death (1)
- sulfotransferase (1)
- suppress VLDL secretion (1)
- suppressor of cytokine signaling (SOCS) (1)
- synovial fluid (1)
- systematischer Review (1)
- systemic response (1)
- systolic function (1)
- tacrolimus formulation (1)
- tannin-protein interaction (1)
- targeted metabolomics (1)
- targeted proteomics (1)
- tea processing (1)
- telbivudine (1)
- telmisartan (1)
- terpenoids (1)
- tetanus toxin (1)
- therapy (1)
- thermal processing (1)
- thermogenesis (1)
- thioredoxin-interacting protein (1)
- thymosin beta 4 (1)
- tissue inhibitior of metalloproteinases 1 (1)
- tocopherol (1)
- tocopherols (1)
- total glycated hemoglobin (1)
- total glycosylated hemoglobin (1)
- trace element (1)
- training intervention (1)
- trans-Golgi (1)
- trans-migration (1)
- transformation product (1)
- transfusion-related acute lung injury (1)
- transgenerational effects (1)
- transient receptor potential (1)
- transmission of hepatitis B virus (HBV) (1)
- transport proteins (1)
- transthyretin (TTR) (1)
- triazole fungicides (1)
- tritrophic system (1)
- tryptic digestion (1)
- tryptophan quenching (1)
- tumor-metastasis (1)
- type 2 diabetes (T2DM) (1)
- type II diabetes (T2DM) (1)
- type-2-diabetes (1)
- ubiquitin proteasomal system (1)
- ultra heat treatment (1)
- ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) (1)
- ultrasound (1)
- underutilized species (1)
- universal coating (1)
- urban (1)
- urinary biomarker (1)
- urine (1)
- valine (1)
- valorization (1)
- variants (1)
- vascular smooth muscle cells (1)
- vesicular trafficking (1)
- veterinary drug (1)
- veterinary drugs (1)
- vicious cycle (1)
- visfatin (1)
- vitamin (1)
- vitamin A deficiency (1)
- vitamin D binding protein (1)
- vitamin D-binding protein (1)
- vitamins (1)
- volatile compounds (1)
- voltage-dependent calcium channels (1)
- weight gain (1)
- weight loss intervention (1)
- western blot (1)
- wheat cultivars (1)
- yield enhancement (1)
- yolk (1)
- zeaxanthin (1)
- zinc binding (1)
- zinc/iron supplementation (1)
Institute
- Institut für Ernährungswissenschaft (872) (remove)
While the underlying mechanisms of Parkinson’s disease (PD) are still insufficiently studied, a complex interaction between genetic and environmental factors is emphasized. Nevertheless, the role of the essential trace element zinc (Zn) in this regard remains controversial. In this study we altered Zn balance within PD models of the versatile model organism Caenorhabditis elegans (C. elegans) in order to examine whether a genetic predisposition in selected genes with relevance for PD affects Zn homeostasis. Protein-bound and labile Zn species act in various areas, such as enzymatic catalysis, protein stabilization pathways and cell signaling. Therefore, total Zn and labile Zn were quantitatively determined in living nematodes as individual biomarkers of Zn uptake and bioavailability with inductively coupled plasma tandem mass spectrometry (ICP-MS/MS) or a multi-well method using the fluorescent probe ZinPyr-1. Young and middle-aged deletion mutants of catp-6 and pdr-1, which are orthologues of mammalian ATP13A2 (PARK9) and parkin (PARK2), showed altered Zn homeostasis following Zn exposure compared to wildtype worms. Furthermore, age-specific differences in Zn uptake were observed in wildtype worms for total as well as labile Zn species. These data emphasize the importance of differentiation between Zn species as meaningful biomarkers of Zn uptake as well as the need for further studies investigating the role of dysregulated Zn homeostasis in the etiology of PD.
Background
Coronavirus disease (COVID-19) has a severe impact on all aspects of patient care. Among the numerous biomarkers of potential validity for diagnostic and clinical management of COVID-19 are biomarkers at the interface of iron metabolism and inflammation.
Methods
The follow-up study included 54 hospitalized patients with laboratory-confirmed COVID-19 with a moderate and severe/critical form of the disease. Iron deficiency specific biomarkers such as iron, ferritin, transferrin receptor, hepcidin, and zinc protoporphyrin (ZnPP) as well as relevant markers of inflammation were evaluated twice: in the first five days when the patient was admitted to the hospital and during five to 15 days; and their validity to diagnose iron deficiency was further assessed. The regression and Receiver Operating Characteristics (ROC) analyses were performed to evaluate the prognosis and determine the probability for predicting the severity of the disease in the first five days of COVID-19.
Results
Based on hemoglobin values, anemia was observed in 21 of 54 patients. Of all iron deficiency anemia-related markers, only ZnPP was significantly elevated (P<0.001) in the anemic group. When patients were grouped according to the severity of disease, slight differences in hemoglobin or other anemia-related parameters could be observed. However, the levels of ZnPP were significantly increased in the severely ill group of patients. The ratio of ZnPP to lymphocyte count (ZnPP/L) had a discrimination power stronger than the neutrophil to lymphocyte count ratio (N/L) to determine disease severity. Additionally, only two markers were independently associated with the severity of COVID-19 in logistic regression analysis; D-dimer (OR (5.606)(95% CI 1.019–30.867)) and ZnPP/L ratio (OR (74.313) (95% CI 1.081–5108.103)).
Conclusions
For the first time ZnPP in COVID-19 patients were reported in this study. Among all iron-related markers tested, ZnPP was the only one that was associated with anemia as based on hemoglobin. The increase in ZnPP might indicate that the underlying cause of anemia in COVID-19 patients is not only due to the inflammation but also of nutritional origin. Additionally, the ZnPP/L ratio might be a valid prognostic marker for the severity of COVID-19.
BackgroundWheat is one of the most common food allergens in early childhood. In contrast to other food allergies, wheat-specific IgE correlates badly with clinical symptoms and relevant components have been identified mostly for wheat-depended exercise-induced anaphylaxis. Moreover, a high percentage of patients present with immediate type symptoms but wheat-specific IgE cannot be detected with commercial available systems. ObjectiveWe addressed the question whether the IgE recognition pattern between wheat allergic (WA) and clinically tolerant (WT) children differs in order to identify individual proteins useful for component-resolved diagnostics. MethodsSera of 106 children with suspected wheat allergy, of whom 44 children had clinical relevant wheat allergy and 62 were tolerant upon oral food challenge, were analyzed for wheat-specific IgE using the ImmunoCap system as well as immunoblots against water and salt soluble, and water-insoluble protein fractions. 40 randomly selected sera were analyzed for specific IgE to 5-gliadin. ResultsSixty-three percent of the WT and 86% of the WA children were sensitized to wheat with >0.35 kU(A)/l in ImmunoCAP analysis. We could confirm the role of -, ss-, -, and -gliadins, and LMW glutenin subunits as major allergens and found also IgE binding to a broad spectrum of water- and salt-soluble protein bands. It is of great importance that wheat allergic and tolerant patients showed IgE binding to the same protein bands. WT and WA did not significantly differ in levels of 5-gliadin-specific IgE. Conclusions & Clinical RelevanceChildren with challenge proven clinical relevant food allergy and tolerant ones had a similar spectrum of IgE binding to the same protein bands. These findings imply that component-resolved diagnostics might not be helpful in the diagnostic work-up of wheat allergy.
Obesity is a risk factor for several major cancers. Associations of weight change in middle adulthood with cancer risk, however, are less clear. We examined the association of change in weight and body mass index (BMI) category during middle adulthood with 42 cancers, using multivariable Cox proportional hazards models in the European Prospective Investigation into Cancer and Nutrition cohort. Of 241 323 participants (31% men), 20% lost and 32% gained weight (>0.4 to 5.0 kg/year) during 6.9 years (average). During 8.0 years of follow-up after the second weight assessment, 20 960 incident cancers were ascertained. Independent of baseline BMI, weight gain (per one kg/year increment) was positively associated with cancer of the corpus uteri (hazard ratio [HR] = 1.14; 95% confidence interval: 1.05-1.23). Compared to stable weight (+/- 0.4 kg/year), weight gain (>0.4 to 5.0 kg/year) was positively associated with cancers of the gallbladder and bile ducts (HR = 1.41; 1.01-1.96), postmenopausal breast (HR = 1.08; 1.00-1.16) and thyroid (HR = 1.40; 1.04-1.90). Compared to maintaining normal weight, maintaining overweight or obese BMI (World Health Organisation categories) was positively associated with most obesity-related cancers. Compared to maintaining the baseline BMI category, weight gain to a higher BMI category was positively associated with cancers of the postmenopausal breast (HR = 1.19; 1.06-1.33), ovary (HR = 1.40; 1.04-1.91), corpus uteri (HR = 1.42; 1.06-1.91), kidney (HR = 1.80; 1.20-2.68) and pancreas in men (HR = 1.81; 1.11-2.95). Losing weight to a lower BMI category, however, was inversely associated with cancers of the corpus uteri (HR = 0.40; 0.23-0.69) and colon (HR = 0.69; 0.52-0.92). Our findings support avoiding weight gain and encouraging weight loss in middle adulthood.
Aim: To investigate the relationship of vitamin D-binding protein (GC) and genetic variation of GC (rs4588, rs7041 and rs2282679) with metabolic syndrome (MetS) in the Thai population. Materials & methods: GCglobulin concentrations were measured by quantitative western blot analysis in 401 adults. All participants were genotyped using TaqMan allelic discrimination assays. Results: GC-globulin levels were significatly lower in MetS subjects than in control subjects, in which significant negative correlations of GC-globulin levels with systolic blood pressure, glucose and age were found. Male participants who carried the GT genotype for rs4588 showed an increased risk of MetS compared with the GG wild-type (odds ratio: 3.25; p = 0.004). Conclusion: GC-globulin concentrations and variation in GC rs4588 were supported as a risk factor for MetS in Thais.
Background: Given the huge impact of vitamin D deficiency on a broad spectrum of diseases such as rickets, osteoporosis, mineral bone disease-vascular calcification syndrome, infectious diseases, but also several types of cancer and CNS diseases, reliable and simple methods to analyze the vitamin D status are urgently needed.
Methods: We developed an easy technique to determine the 25-OH vitamin D status from dried blood samples on filter paper. This allows determination of the 25-OH vitamin D status independently of venous blood taking, since only sampling of capillary blood is required for this new method. We compared the results of vitamin D measurements from venous blood of 96 healthy blood donors with those from capillary blood taken from the same patients at the same time. The capillary blood was dried on filter paper using the D-Vital ID dry-blood collection system.
Results: 25-OH vitamin D concentration data from extracted dried capillary blood filters correlated very well with data obtained after direct measurement of venous blood samples of the same blood donor (R: 0.7936; p<0.0001). The correlation was linear over the whole range of 25-OH vitamin D concentrations seen in this study. A Bland-Altman plot revealed good agreement between both tests.
Conclusions: The D-Vital ID dry-blood collection system showed an excellent performance as compared to the classical way of 25-OH vitamin D measurement from venous blood. This new technique will facilitate easy and reliable measurement for vitamin D status, in particular, in rural or isolated areas, developing countries, and field studies.
Preclinical work indicates that calcitriol restores vascular function by normalizing the endothelial expression of cyclooxygenase-2 and thromboxane-prostanoid receptors in conditions of estrogen deficiency and thus prevents the thromboxane-prostanoid receptor activation-induced inhibition of nitric oxide synthase. Since endothelial dysfunction is a key factor in the pathogenesis of cardiovascular diseases, this finding may have an important translational impact. It provides a clear rationale to use endothelial function in clinical trials aiming to find the optimal dose of vitamin D for the prevention of cardiovascular events in postmenopausal women.