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Patient monitoring technology has been used to guide therapy and alert staff when a vital sign leaves a predefined range in the intensive care unit (ICU) for decades. However, large amounts of technically false or clinically irrelevant alarms provoke alarm fatigue in staff leading to desensitisation towards critical alarms.
With this systematic review, we are following the Preferred Reporting Items for Systematic Reviews (PRISMA) checklist in order to summarise scientific efforts that aimed to develop IT systems to reduce alarm fatigue in ICUs. 69 peer-reviewed publications were included. The majority of publications targeted the avoidance of technically false alarms, while the remainder focused on prediction of patient deterioration or alarm presentation.
The investigated alarm types were mostly associated with heart rate or arrhythmia, followed by arterial blood pressure, oxygen saturation, and respiratory rate.
Most publications focused on the development of software solutions, some on wearables, smartphones, or headmounted displays for delivering alarms to staff.
The most commonly used statistical models were tree-based. In conclusion, we found strong evidence that alarm fatigue can be alleviated by IT-based solutions.
However, future efforts should focus more on the avoidance of clinically non-actionable alarms which could be accelerated by improving the data availability.
One of the most challenging difficulties for incumbent organisations, especially small- and medium-sized enterprises (SMEs), is to manage digital transformation driven by technological change. Incumbent organisations' responses to digital transformation have been extensively studied in the current literature.
However, most research neglects digital transformation in SMEs. There are hardly any valid developed measures for the maturity of digital transformation. We present a holistic digital transformation maturity model based on an extensive literature review, qualitative computer-assisted data analysis, and empirical findings.
The digital transformation maturity model focuses on small- and medium-sized enterprises' unique features and characteristics.
We proved the practical applicability and relevance of the digital transformation maturity model in an extensive study involving various organisations, particularly German SMEs (n = 310).
Organisations can use this model to assess themselves initially and, through this process, gain a comprehensive understanding of the multiple forms of digital transformation.
It is often claimed that the entropy of a network's degree distribution is a proxy for its robustness. Here, we clarify the link between degree distribution entropy and giant component robustness to node removal by showing that the former merely sets a lower bound to the latter for randomly configured networks when no other network characteristics are specified. Furthermore, we show that, for networks of fixed expected degree that follow degree distributions of the same form, the degree distribution entropy is not indicative of robustness. By contrast, we show that the remaining degree entropy and robustness have a positive monotonic relationship and give an analytic expression for the remaining degree entropy of the log-normal distribution. We also show that degree-degree correlations are not by themselves indicative of a network's robustness for real networks. We propose an adjustment to how mutual information is measured which better encapsulates structural properties related to robustness.
The dismembered bible
(2021)
It is often presumed that biblical redaction was invariably done using conventional scribal methods, meaning that when editors sought to modify or compile existing texts, they would do so in the process of rewriting them upon new scrolls. There is, however, substantial evidence pointing to an alternative scenario: Various sections of the Hebrew Bible appear to have been created through a process of material redaction. In some cases, ancient editors simply appended new sheets to existing scrolls. Other times, they literally cut and pasted their sources, carving out patches of text from multiple manuscripts and then gluing them together like a collage. Idan Dershowitz shows how this surprising technique left behind telltale traces in the biblical text - especially when the editors made mistakes - allowing us to reconstruct their modus operandi. Material evidence from the ancient Near East and elsewhere further supports his hypothesis.
With the present study, we introduce a fast and robust method to calculate the source displacement spectra of small earthquakes on a local to regional scale. The work is based on the publicly available Qopen method of full envelope inversion, which is further tuned for the given purpose. Important source parameters-seismic moment, moment magnitude, corner frequency, and high-frequency fall off-are determined from the source spectra by fitting a simple earthquake source model. The method is demonstrated by means of a data set comprising the 2018 West Bohemia earthquake swarm. We report moment magnitudes, corner frequencies, and centroid moment tensors inverted from short-period body waves with the Grond package for all earthquakes with a local magnitude larger than 1.8. Moment magnitudes calculated by envelope inversion show a very good agreement to moment magnitudes resulting from the probabilisitc moment tensor inversion. Furthermore, source displacement spectra from envelope inversion show a good agreement with spectra obtained by multiple taper analysis of the direct onsets of body waves but are not affected by the large scatter of the second. The seismic moments obtained with the envelope inversion scale with corner frequencies according to M-0 proportional to f(c)(-4.7). Earthquakes of the present data set result in a smaller stress drop for smaller magnitudes. Self-similarity of earthquake rupture is not observed. In addition, we report frequency-dependent site amplification at the used stations.
We discuss the coherent splitting and recombining of a nanoparticle in a mesoscopic "closed-loop" Stern-Gerlach interferometer in which the observable is the spin of a single impurity embedded in the particle.
This spin, when interacting with a pulsed magnetic gradient, generates the force on the particle.
We calculate the internal decoherence, which arises as the displaced impurity excites internal degrees of freedom (phonons) that may provide WelcherWeg information and preclude interference.
We estimate the constraints this decoherence channel puts on future interference experiments with massive objects. We find that for a wide range of masses, forces, and temperatures, phonons do not inhibit Stern-Gerlach interferometry with micro-scale objects.
However, phonons do constitute a fundamental limit on the splitting of larger macroscopic objects if the applied force induces phonons.
The radiation model is a parameter-free model of human mobility that has been applied primarily for short-distance moves, such as commuting. When applied to migration, it underestimates the number of long-range moves, such as between different US states. Here we show that it additionally suffers from a conceptual inconsistency that can have substantial numerical effects on long-distance moves.
We propose a modification of the radiation model that introduces a dependence on the angle between any two alternative potential destinations, accounting for the possibility that migrants may have preferences about the approximate direction of their move.
We demonstrate that this modification mitigates the conceptual inconsistency and improves the model fit to observational migration data, without introducing any fitting parameters.
The Shanderman lamprophyre dykes crop out in the western part of the Alborz Mountains (Talesh).
These rocks are classified as camptonites, composed of primary olivine, Ti-rich diopside, kaersutite, biotite, plagioclase, K-feldspar, and minor Ti-rich spinels, magnetite, pentlandite-pyrrhotite/chalcopyrite, and powellite-scheelite. Secondary analcime-wairakite, serpentines, and prehnite are common minor minerals within the studied rocks.
Olivine, Ti-rich diopside, spinel, and amphibole show distinct chemical zoning. Spinels display a core-to-rim decrease in Cr2O3, MgO, and Al2O3 concentrations and an increase in TiO2 and FeOT (total Fe as FeO), reflecting the oxidation state increase due to hydrothermal fluid influx. Low SiO2 contents (< 42 wt%), high MgO (12.44 to 13.98 wt%), and Fe2O3T (12.76 to 13.43 wt%), Cr (318-537 mu g/g) and Ni (231-327 mu g/g) contents indicate the ultrabasic nature of the rocks.
The samples show potassic character (2.1-2.8 wt% K2O), along with elevated LREE and LILE, and also exhibit minor positive Eu anomalies (Eu/Eu* = 1.09 to 1.20).
Olivine-spinel geothermometry indicates a maximum crystallization temperature of 1227 degrees C (ave. 988 degrees C +/- 65 degrees C).
Exsolution of pentlandite-pyrrhotite/chalcopyrite solid solutions occurred during magma cooling and crystallization. At lower temperatures, analcime-wairakite and prehnite partially replaced plagioclases.
The geochemical modeling of the rocks indicates the Shanderman lamprophyre magmas were derived from low-grade melting (< 5%) of amphibole-bearing garnet lherzolite source without or with very few phlogopites.
The primary magma of Shanderman lamprophyres was derived from a depth of similar to 135 km by partial melting of a metasomatized mantle source in a post-collisional environment.
Contour scanning and process gas type are process parameters typically considered achieving second order effects compared to first order factors such as laser power and scanning speed.
The present work highlights that contour scanning is crucial to ensure geometrical accuracy and thereby the high performance under uniaxial compression of complex Alloy 718 lattice structures.
Studies of X-ray computed tomography visualizations of as-built and compression-strained structures reveal the continuous and smooth bending and compression of the walls, and the earlier onset of internal contact appearance in the denser lattices printed with contour. In contrast, the effect of addition of He to the Ar process gas appears to have limited influence on the mechanical response of the lattices and their microstructure as characterized by electron backscattered diffraction.
However, the addition of He proved to significantly enhance the cooling rate and to reduce the amount of the generated spatters as evidenced by in situ monitoring of the process emissions, which is very promising for the process stability and powder reusability during laser powder bed fusion.
In this work, we investigate the photo-aquation reaction of the ferrocyanide anion with multi-edge picosecond soft X-ray spectroscopy.
Combining the information of the iron L-edge with nitrogen and oxygen K-edges, we carry out a complete characterization of the bonding channels in the [Fe(CN)(5)(H2O)](3-) photo-product.
We observe clear spectral signatures of covalent bonding between water and the metal, reflecting the mixing of the Fe d(z)(2) orbital with the 3a(1) and 4a(1) orbitals of H2O. Additional fingerprints related to the symmetry reduction and the resulting loss in orbital degeneracy are also reported.
The implications of the elucidated fingerprints in the context of future ultra-fast experiments are also discussed.