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The book offers a comprehensive overview of current research in Slavic linguistics from a theoretical and experimental perspective and from a variety of languages. The selected papers from the 11th European Conference on Formal Description of Slavic Languages (FDSL 11) that took place at the University of Potsdam in 2015, illustrate the advancement of Slavic linguistic studies and their outreach for the development of general linguistics. The guest paper by Noam Chomsky at the beginning of the book sets a clear sign in this direction and may be taken as an acknowledgement of the field.
Developing a new paradigm
(2020)
Internet users commonly agree that it is important for them to protect their personal data. However, the same users readily disclose their data when requested by an online service. The dichotomy between privacy attitude and actual behaviour is commonly referred to as the “privacy paradox”. Over twenty years of research were not able to provide one comprehensive explanation for the paradox and seems even further from providing actual means to overcome the paradox. We argue that the privacy paradox is not just an instantiation of the attitude-behaviour gap. Instead, we introduce a new paradigm explaining the paradox as the result of attitude-intention and intentionbehaviour gaps. Historically, motivational goal-setting psychologists addressed the issue of intentionbehaviour gaps in terms of the Rubicon Model of Action Phases and argued that commitment and volitional strength are an essential mechanism that fuel intentions and translate them into action. Thus, in this study we address the privacy paradox from a motivational psychological perspective by developing two interventions on Facebook and assess whether the 287 participants of our online experiment actually change their privacy behaviour. The results demonstrate the presence of an intentionbehaviour gap and the efficacy of our interventions in reducing the privacy paradox.
Does a smile open all doors?
(2020)
Online photographs govern an individual’s choices across a variety of contexts. In sharing arrangements, facial appearance has been shown to affect the desire to collaborate, interest to explore a listing, and even willingness to pay for a stay. Because of the ubiquity of online images and their influence on social attitudes, it seems crucial to be able to control these aspects. The present study examines the effect of different photographic self-disclosures on the provider’s perceptions and willingness to accept a potential co-sharer. The findings from our experiment in the accommodation-sharing context suggest social attraction mediates the effect of photographic self-disclosures on willingness to host. Implications of the results for IS research and practitioners are discussed.
As Industry 4.0 infrastructures are seen as highly evolutionary environment with volatile, and time-dependent workloads for analytical tasks, particularly the optimal dimensioning of IT hardware is a challenge for decision makers because the digital processing of these tasks can be decoupled from their physical place of origin. Flexible architecture models to allocate tasks efficiently with regard to multi-facet aspects and a predefined set of local systems and external cloud services have been proven in small example scenarios. This paper provides a benchmark of existing task realization strategies, composed of (1) task distribution and (2) task prioritization in a real-world scenario simulation. It identifies heuristics as superior strategies.
Die Methodenlehre ist das Grundlagenfach mit der größten Nähe zur Praxis. Dennoch bewegt sie sich oftmals auf einer hohen Abstraktionsebene und ihr Zweck wird im juristischen Alltag, im Studium oder in der Praxis nicht immer erreicht. Dominiert vom Zivil- und insbesondere Arbeitsrecht, werden Besonderheiten des Öffentlichen Rechts und des Strafrechts ebenso wenig allgemein zur Kenntnis genommen wie (wieder) aktuelle Ansätze etwa der Rechtsrhetorik, der ökonomischen Analyse und der praktischen Jurisprudenz. Es sind eher interne Diskussionen, die innerhalb der Fachdisziplinen und in den noch kleineren Kreisen der methodisch Denkenden geführt werden. Im Zentrum des Kolloquiums stand daher die Frage, ob es eine allgemeine Methodenlehre gibt oder jeweils spezifische Methoden. Ziel war es, über Generationen, Fächergrenzen und Schulen hinaus ins Gespräch zu kommen. Der Tagungsband vereint die Referate und kurzen Zusammenfassungen der anregenden Diskussionen.
Stetig steigende Studierendenzahlen und Studierendenerwartungen der „Generation Z“ als „Digital Natives“ stellen Hochschulen bei gleichbleibenden Lehrressourcen vor vielfältige technische, didaktische, organisationale und curriculare Herausforderungen. Aufgrund ihrer Diversität und Heterogenität gibt es keinen einheitlichen Weg der digitalen Transformation im Hochschulsektor. Curricula, Studienstrukturen, Präsenzlehre und digitale Lehr- und Lernangebote müssen auf die jeweiligen Hochschulen, Zielgruppen und Kooperationspartner zugeschnitten werden. Dabei müssen auch neue Zielgruppen erreicht werden, z.B. Berufstätige und Teilzeitstudierende, und die Individualisierung sowie die nationale und internationale Studierendenmobilität gefördert werden. Kompetenzen für die Informationsextraktion aus Lern- und Studienprozessen, (Big) Data Analytics und Visualisierung, Künstliche Intelligenz und Augmented Reality müssen in Hochschulen aufgebaut werden. Von der digitalen Transformation sind alle Bereiche von Hochschulen betroffen, z.B. Präsidien, Fakultäten und gleichgestellte Einrichtungen, Universitätsverwaltungen, Forschungseinrichtungen sowie zentrale und dezentrale (IT-)Dienstleister, die sich mit schnell verändernden Anforderungs- und Rollenprofilen anpassen müssen. Ferner sind rechtliche Rahmenbedingungen zu betrachten, z.B. Datenschutzanforderungen, um die Potenziale von digitalen Lehr- und Lernangeboten und von digitalen Medien in der Lehre zu erschließen. Dieser Track diskutiert theoretische, konzeptionelle, gestaltungsorientierte, empirische und verhaltensorientierte Beiträge.
Background:
Anti-TNFα monoclonal antibodies (mAbs) are a well-established treatment for patients with Crohn’s disease (CD). However, subtherapeutic concentrations of mAbs have been related to a loss of response during the first year of therapy1. Therefore, an appropriate dosing strategy is crucial to prevent the underexposure of mAbs for those patients. The aim of our study was to assess the impact of different dosing strategies (fixed dose or body size descriptor adapted) on drug exposure and the target concentration attainment for two different anti-TNFα mAbs: infliximab (IFX, body weight (BW)-based dosing) and certolizumab pegol (CZP, fixed dosing). For this purpose, a comprehensive pharmacokinetic (PK) simulation study was performed.
Methods:
A virtual population of 1000 clinically representative CD patients was generated based on the distribution of CD patient characteristics from an in-house clinical database (n = 116). Seven dosing regimens were investigated: fixed dose and per BW, lean BW (LBW), body surface area, height, body mass index and fat-free mass. The individual body size-adjusted doses were calculated from patient generated body size descriptor values. Then, using published PK models for IFX and CZP in CD patients2,3, for each patient, 1000 concentration–time profiles were simulated to consider the typical profile of a specific patient as well as the range of possible individual profiles due to unexplained PK variability across patients. For each dosing strategy, the variability in maximum and minimum mAb concentrations (Cmax and Cmin, respectively), area under the concentration-time curve (AUC) and the per cent of patients reaching target concentration were assessed during maintenance therapy.
Results:
For IFX and CZP, Cmin showed the highest variability between patients (CV ≈110% and CV ≈80%, respectively) with a similar extent across all dosing strategies. For IFX, the per cent of patients reaching the target (Cmin = 5 µg/ml) was similar across all dosing strategies (~15%). For CZP, the per cent of patients reaching the target average concentration of 17 µg/ml ranged substantially (52–71%), being the highest for LBW-adjusted dosing.
Conclusion:
By using a PK simulation approach, different dosing regimen of IFX and CZP revealed the highest variability for Cmin, the most commonly used PK parameter guiding treatment decisions, independent upon dosing regimen. Our results demonstrate similar target attainment with fixed dosing of IFX compared with currently recommended BW-based dosing. For CZP, the current fixed dosing strategy leads to comparable percentage of patients reaching target as the best performing body size-adjusted dosing (66% vs. 71%, respectively).
From learners to educators
(2020)
The rapid growth of technology and its evolving potential to support the transformation of teaching and learning in post-secondary institutions is a major challenge to the basic understanding of both the university and the communities it serves. In higher education, the standard forms of learning and teaching are increasingly being challenged and a more comprehensive process of differentiation is taking place. Student-centered teaching methods are becoming increasingly important in course design and the role of the lecturer is changing from the knowledge mediator to moderator and learning companion. However, this is accelerating the need for strategically planned faculty support and a reassessment of the role of teaching and learning. Even though the benefits of experience-based learning approaches for the development of life skills are well known, most knowledge transfer is still realized through lectures in higher education. Teachers have the goal to design the curriculum, new assignments, and share insights into evolving pedagogy. Student engagement could be the most important factor in the learning success of university students, regardless of the university program or teaching format. Against this background, this article presents the development, application, and initial findings of an innovative learning concept. In this concept, students are allowed to deal with a scientific topic, but instead of a presentation and a written elaboration, their examination consists of developing an online course in terms of content, didactics, and concept to implement it in a learning environment, which is state of the art. The online courses include both self-created teaching material and interactive tasks. The courses are created to be available to other students as learning material after a review process and are thus incorporated into the curriculum.
How games spoil creativity
(2020)
The demand for a creative workforce is every growing and effective measures to improve individual creativity are searched for. This study analyzes the possibility to use games as a prime for a creative mindset. Two short entertainment games, plus a no-game-comparison condition were set up in three versions of an online-study, along with two creativity tasks and scales to assess the individual creative mindset (fixed-vs-growth, creative self-efficacy and affect). Results indicate priming effects of the games, but in the opposite intended direction: gaming diminished the creative test performances. Those playing the games reported more ideas in the open-ended creative problem task, but those answers were of less quality and they solved less closed-problem items compared to those not playing. An impact of further mindset differences could be ruled out.