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- cognition (2)
- cognitive-behavioral control (2)
- cognitive-control (2)
- collaborative consumption (2)
- college students (2)
- colonialism (2)
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- coloring agents (2)
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- communities (2)
- comparison of devices (2)
- complex networks (2)
- composites (2)
- composition (2)
- comprehension (2)
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- confidence (2)
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- continental lithosphere (2)
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- continuous time random walk (2)
- contract workers (2)
- contrast effect (2)
- conversational implicature (2)
- converting factor (2)
- cooperation (2)
- coordination (2)
- copper-related disorders (2)
- core PG1351 (2)
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- cortisol (2)
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- cross ownership (2)
- crust (2)
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- crystal orientation (2)
- cyanobacteria (2)
- cyanobacterial sucrose-phosphatase (2)
- cyber victimization (2)
- cyberbullying victimization (2)
- cysteine alkylation (2)
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- data (2)
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- data fusion (2)
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- data sharing (2)
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- dehydration (2)
- density (2)
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- diffraction (2)
- digital bathymetric model (2)
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- dimension independent bound (2)
- dimerization of 4-nitrothiophenol (2)
- disaster risk reduction (2)
- discrepancy principle (2)
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- diselenide (2)
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- dispersal filtering (2)
- diversity climate (2)
- donor (2)
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- dual GLP-1/glucagon receptor agonist (2)
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- e-z reader (2)
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- earth system model (2)
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- earthquake source observations (2)
- eastern continental Asia (2)
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- ecosystem services provisioning (2)
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- effectiveness (2)
- effects (2)
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- electropolymerization (2)
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- emotional difficulties (2)
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- end-stage kidney disease (2)
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- ensemble and time averaged mean squared displacement (2)
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- enzyme (2)
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- equatorial electrojet (2)
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- equine (2)
- erosion hotspots (2)
- error reduction (2)
- ethnic social capital (2)
- ethnic-racial identity (2)
- europe (2)
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- evaluative study (2)
- evaporation (2)
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- event expectations (2)
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- excitonic materials (2)
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- exendin-4 (2)
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- exhaustivity (2)
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- expectancies (2)
- experiences survey (2)
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- exploit (2)
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- exposed water ice (2)
- exposome (2)
- exposome‐ wide association study (2)
- expression patterns (2)
- external training load (2)
- externalization (2)
- extinction drivers (2)
- extinction event (2)
- extremal values (2)
- eye tracking (2)
- family farming (2)
- fastest first-passage time of N walkers (2)
- fault creep (2)
- feedback (2)
- feeding behaviour (2)
- ferroelectric polymers (2)
- fetal origins hypothesis (2)
- fiber actuators (2)
- field-aligned currents (2)
- filter (2)
- fine dining (2)
- firmware update (2)
- fitness (2)
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- flagellum (2)
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- floating mat (2)
- flood (2)
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- fluorescence microscopy (2)
- fluorinated organic spacer (2)
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- focus group (2)
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- forage gaps (2)
- foraging (2)
- force (2)
- force profiles (2)
- forebrain (2)
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- formate dehydrogenase (2)
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- frictional properties (2)
- fsQCA (2)
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- functionalization (2)
- gait (2)
- gait analysis (2)
- galaxies (2)
- galaxies: high-redshift (2)
- gallbladder cancer (2)
- gamma rays: general (2)
- gamma-rays: general (2)
- gas phase electron spectroscopy (2)
- gate effect (2)
- gender stereotype trait (2)
- gene delivery (2)
- gene expression (2)
- generalized dissimilarity modelling (2)
- genetic differentiation (2)
- genetic diversity (2)
- genetic programming (2)
- genome-wide association (2)
- genotype (2)
- geochronology (2)
- geographic distribution (2)
- gestural organization (2)
- glacial maximum (2)
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- global mean temperature (2)
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- glucocorticoid receptor (2)
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- gold nanoparticle assembly (2)
- government (2)
- gradient boosting (2)
- gradient flow (2)
- grafted polymers (2)
- grain-size distribution (2)
- granulite (2)
- graph transformation systems (2)
- green polymers (2)
- greenland shelf (2)
- grief (2)
- ground-motion modelling (2)
- groundwater inflow (2)
- groundwater vulnerability (2)
- growth restriction (2)
- gulf coastal plain (2)
- gwas (2)
- habit formation (2)
- habituation (2)
- habituation-switch paradigm (2)
- handheld device (2)
- hanging wall (2)
- hate speech detection (2)
- haute cuisine (2)
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- heat stress (2)
- heat stress memory (2)
- heat-stress (2)
- heavy precipitation (2)
- heme (2)
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- heterojunction silicon solar cells (2)
- heuristics (2)
- hierarchy-of-hypotheses approach (2)
- high dimensional (2)
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- high‐risk drinking (2)
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- hormones (2)
- host adaptation (2)
- household analysis (2)
- hsp70 (2)
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- hybrid modelling (2)
- hydrological drought (2)
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- hydrological signatures (2)
- hydroxyl-functional poly(2-vinyl pyridine) (2)
- hyperactivity (2)
- hyperbolic tilings (2)
- hyperthermia (2)
- ice absorption features (2)
- ice sheet (2)
- ideal-observer model (2)
- identifying influential nodes (2)
- identity (2)
- identity development (2)
- image processing (2)
- imaging (2)
- immune evasion cluster (2)
- immunogenicity (2)
- impact on pre-activated Achilles tendon (2)
- implicit bias (2)
- in-vitro-synthesis (2)
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- induced pluripotent stem cells (2)
- inertial measurement unit (2)
- infant development (2)
- infant word learning (2)
- infection (2)
- infiltration (2)
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- information (2)
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- internal load (2)
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- internalization (2)
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- internet addiction (2)
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- invasibility (2)
- invasion success (2)
- ionic liquid (2)
- ionogel (2)
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- lactate (2)
- lake Donggi Cona (2)
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- landscape generator (2)
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- margins (2)
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- mechanism (2)
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- molybdenum (2)
- molybdopterin synthase (2)
- monomers (2)
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- motion capture (2)
- motor neurons (2)
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- multi-slab (2)
- multidisciplinary pain treatment (2)
- multiplicative noise (2)
- multishell (2)
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- murchison meteorite (2)
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- neurodegenerative diseases (2)
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- nonlinear operator (2)
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- origination (2)
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- part 1 (2)
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- plant Mediator (2)
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- poly (acrylic acid, sodium salt) (2)
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- polyacrylamide (2)
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- seed bank (2)
- selenoprotein P (2)
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- self-report measures (2)
- semantics-pragmatics interface (2)
- semi-arid regions (2)
- sensitivity (2)
- sensorimotor exercise training (2)
- sentence comprehension (2)
- seperation (2)
- sequence dependence (2)
- sequence-controlled polymers (2)
- sequence-structure-function relationship (2)
- sequencing error (2)
- serine cycle (2)
- sexual coercion (2)
- sexual self-esteem (2)
- shape‐memory polymer actuators (2)
- shock proteins (2)
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- shotgun sequencing (2)
- shrub-encroachment (2)
- signal propagation (2)
- signal transduction (2)
- similarity measures (2)
- simulations (2)
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- size (2)
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- sociometric neglect (2)
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- sodium (2)
- soft X-ray beamline (2)
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- soft robotics (2)
- soil fatigue (2)
- soil texture (2)
- solar cells (2)
- solar coronal mass ejections (2)
- solar storm (2)
- solubility (2)
- solving of tasks (2)
- somatic comorbidity (2)
- sorghum (2)
- source regions (2)
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- space (2)
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- spatial frequencies (2)
- spatial frequency (SF) (2)
- spatial localization (2)
- spatial-temporal (2)
- speakers (2)
- special sensor microwave imager (2)
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- species composition (2)
- specific surface area (2)
- spectra (2)
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- speech kinematics (2)
- speech motor control (2)
- speech production (2)
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- splitting (2)
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- standard metrics (2)
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- state (2)
- stationary stochastic process (2)
- status markers (2)
- stellar coronal mass ejections (2)
- stratigraphy (2)
- streamflow (2)
- streamflow trends (2)
- streamflow variability (2)
- stress memory (2)
- structure (2)
- study (2)
- subcellular localization (2)
- subdiffusion (2)
- subject-verb agreement (2)
- submerged sequence (2)
- subsidence (2)
- sugar signalling (2)
- summer monsoon (2)
- support vector machine (2)
- surface plasmon resonance (2)
- surface temperatures (2)
- surface–groundwater interactions (2)
- surveillance (2)
- sustainable development (2)
- sustained casing pressure (2)
- syllables (2)
- symmetric modes (2)
- syntactic priming (2)
- synthesized voice (2)
- systems (2)
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- tasks (2)
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- teacher–student relationship (2)
- teaching (2)
- teaching quality (2)
- team sports (2)
- technology (2)
- tectonic inversion (2)
- temperature dependence (2)
- temperature-related mortality (2)
- temporal frequency (2)
- temporary wetland (2)
- testis (2)
- text-to-speech (2)
- therapeutics (2)
- thermal-stress (2)
- thermokarst (2)
- thermokarst lakes (2)
- thickness-displacement relationships (2)
- thin films (2)
- tibetan plateau (2)
- tide gauge observations (2)
- time-scale (2)
- time-series mapping (2)
- timing (2)
- top-down parsing (2)
- total electron-content (2)
- trajectory data (2)
- transcript (2)
- transcription (2)
- transcriptional memory (2)
- transfer dynamics (2)
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Challenges, triggers and initiators of climate policies and implications for policy formulation
(2020)
The combined effect of ultraviolet (UV) light soaking and self-assembled monolayer deposition on the work function (WF) of thin ZnO layers and on the efficiency of hole injection into the prototypical conjugated polymer poly(3-hexylthiophen-2,5-diyl) (P3HT) is systematically investigated. It is shown that the WF and injection efficiency depend strongly on the history of UV light exposure. Proper treatment of the ZnO layer enables ohmic hole injection into P3HT, demonstrating ZnO as a potential anode material for organic optoelectronic devices. The results also suggest that valid conclusions on the energy-level alignment at the ZnO/organic interfaces may only be drawn if the illumination history is precisely known and controlled. This is inherently problematic when comparing electronic data from ultraviolet photoelectron spectroscopy (UPS) measurements carried out under different or ill-defined illumination conditions.
Background:
Anti-TNFα monoclonal antibodies (mAbs) are a well-established treatment for patients with Crohn’s disease (CD). However, subtherapeutic concentrations of mAbs have been related to a loss of response during the first year of therapy1. Therefore, an appropriate dosing strategy is crucial to prevent the underexposure of mAbs for those patients. The aim of our study was to assess the impact of different dosing strategies (fixed dose or body size descriptor adapted) on drug exposure and the target concentration attainment for two different anti-TNFα mAbs: infliximab (IFX, body weight (BW)-based dosing) and certolizumab pegol (CZP, fixed dosing). For this purpose, a comprehensive pharmacokinetic (PK) simulation study was performed.
Methods:
A virtual population of 1000 clinically representative CD patients was generated based on the distribution of CD patient characteristics from an in-house clinical database (n = 116). Seven dosing regimens were investigated: fixed dose and per BW, lean BW (LBW), body surface area, height, body mass index and fat-free mass. The individual body size-adjusted doses were calculated from patient generated body size descriptor values. Then, using published PK models for IFX and CZP in CD patients2,3, for each patient, 1000 concentration–time profiles were simulated to consider the typical profile of a specific patient as well as the range of possible individual profiles due to unexplained PK variability across patients. For each dosing strategy, the variability in maximum and minimum mAb concentrations (Cmax and Cmin, respectively), area under the concentration-time curve (AUC) and the per cent of patients reaching target concentration were assessed during maintenance therapy.
Results:
For IFX and CZP, Cmin showed the highest variability between patients (CV ≈110% and CV ≈80%, respectively) with a similar extent across all dosing strategies. For IFX, the per cent of patients reaching the target (Cmin = 5 µg/ml) was similar across all dosing strategies (~15%). For CZP, the per cent of patients reaching the target average concentration of 17 µg/ml ranged substantially (52–71%), being the highest for LBW-adjusted dosing.
Conclusion:
By using a PK simulation approach, different dosing regimen of IFX and CZP revealed the highest variability for Cmin, the most commonly used PK parameter guiding treatment decisions, independent upon dosing regimen. Our results demonstrate similar target attainment with fixed dosing of IFX compared with currently recommended BW-based dosing. For CZP, the current fixed dosing strategy leads to comparable percentage of patients reaching target as the best performing body size-adjusted dosing (66% vs. 71%, respectively).
The termprocess modelis widely used, but rarely agreed upon. This paper proposes a framework for characterizing and building cognitive process models. Process models model not only inputs and outputs but also model the ongoing information transformations at a given level of abstraction. We argue that the following dimensions characterize process models: They have a scope that includes different levels of abstraction. They specify a hypothesized mental information transformation. They make predictions not only for the behavior of interest but also for processes. The models' predictions for the processes can be derived from the input, without reverse inference from the output data. Moreover, the presumed information transformation steps are not contradicting current knowledge of human cognitive capacities. Lastly, process models require a conceptual scope specifying levels of abstraction for the information entering the mind, the proposed mental events, and the behavior of interest. This framework can be used for refining models before testing them or after testing them empirically, and it does not rely on specific modeling paradigms. It can be a guideline for developing cognitive process models. Moreover, the framework can advance currently unresolved debates about which models belong to the category of process models.
In the comment on "Varves of the Dead Sea sedimentary record." Quaternary Science Reviews 215 (Ben Dor et al., 2019): 173-184. by R. Bookman, two recently published papers are suggested to prove that the interpretation of the laminated sedimentary sequence of the Dead Sea, deposited mostly during MIS2 and Holocene pluvials, as annual deposits (i.e., varves) is wrong. In the following response, we delineate several lines of evidence which coalesce to demonstrate that based on the vast majority of evidence, including some of the evidence provided in the comment itself, the interpretation of these sediments as varves is the more likely scientific conclusion. We further discuss the evidence brought up in the comment and its irrelevance and lack of robustness for addressing the question under discussion.