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- acceleration (4)
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- accretion, accretion disks (4)
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- classification (4)
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- community effect on height (4)
- computed tomography (4)
- conjugated polymers (4)
- construction (4)
- contrast (4)
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- coping (4)
- core (4)
- correlations (4)
- cue-based retrieval (4)
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- data (4)
- database (4)
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- events (4)
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- eye-movement monitoring (4)
- facilitation (4)
- feminism (4)
- fiction (4)
- films (4)
- first passage time (4)
- first-passage time (4)
- flood risk management (4)
- flooding (4)
- fluorescence microscopy (4)
- force (4)
- freshwater (4)
- galaxies: fundamental parameters (4)
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- gelatin (4)
- genetics (4)
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- global (4)
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- maturity (4)
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- morphological processing (4)
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- multiplicative noise (4)
- muscle (4)
- museum specimens (4)
- n-alkanes (4)
- narcissism (4)
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- neutrinos (4)
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- nuclear envelope (4)
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- organizations (4)
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- overweight (4)
- oxygen (4)
- pain (4)
- palladium (4)
- parafoveal processing (4)
- parliamentary government (4)
- partial clone (4)
- partial melting (4)
- participatory research (4)
- patterns (4)
- periodization (4)
- peroxides (4)
- perpetration (4)
- phase transition (4)
- phase transitions (4)
- phenotyping (4)
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- phosphate (4)
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- phytolith (4)
- picture naming (4)
- picture-word interference (4)
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- properties (4)
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- radicals (4)
- reflection (4)
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- regression (4)
- rejection sensitivity (4)
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- responses (4)
- retinol (4)
- retinol-binding protein 4 (4)
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- river incision (4)
- root traits (4)
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- salt stress (4)
- school children (4)
- sea-level rise (4)
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- self-concept (4)
- self-healing (4)
- semantic (4)
- semantics (4)
- semi-arid (4)
- sensitivity analysis (4)
- sex (4)
- sexual victimization (4)
- shape memory (4)
- sharing economy (4)
- shrub encroachment (4)
- silicon (4)
- site effects (4)
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- starch phosphorylation (4)
- stars: black holes (4)
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- starspots (4)
- statistical seismology (4)
- stochastic models (4)
- stochastic resetting (4)
- strategic growth adjustments (4)
- stroke (4)
- structure elucidation (4)
- support vector machine (4)
- surface (4)
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- surface-enhanced Raman scattering (4)
- surveillance (4)
- suspended sediment (4)
- sustainable development (4)
- systems biology (4)
- tailspike protein (4)
- teaching quality (4)
- thaliana (4)
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- crystallization behavior (2)
- cue validity (2)
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- cyberbullying victimization (2)
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- dimerization (2)
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- dual GLP-1/glucagon receptor agonist (2)
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- duration (2)
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- orogenic peridotite (2)
- orogenic processes (2)
- orogeny (2)
- orographic rainfall (2)
- orthopedic (2)
- osmotic-pressure (2)
- osteoblast (2)
- other-race effect (2)
- outbreak (2)
- outcome measures (2)
- output analysis (2)
- overland flow (2)
- overreaching (2)
- overtraining (2)
- overuse injuries (2)
- oxidation state (2)
- oxygen heterocycles (2)
- oxygen plasma (2)
- p-Aminophenol (2)
- p53 (2)
- pQCT (2)
- palaeoenvironmental proxies (2)
- palaeoenvironmental reconstruction (2)
- paleo-sediment (2)
- paleoceanography (2)
- paleoecology (2)
- paleolimnology (2)
- paleovegetation (2)
- palmitoylation (2)
- panic (2)
- parafoveal preview benefit (2)
- parafoveal vision (2)
- parameter (2)
- parameters (2)
- parasitoid (2)
- parchment (2)
- parental mediation (2)
- parenting (2)
- parents (2)
- particle filter (2)
- particles (2)
- particulate matter (2)
- party competition (2)
- pasture (2)
- pathway (2)
- pathways (2)
- patient education (2)
- pea (2)
- peace (2)
- peacebuilding (2)
- peak height velocity (2)
- peak torque (2)
- pediatrics (2)
- peer influences (2)
- peers (2)
- pension insurance (2)
- perceived predation risk (2)
- perceived stress (2)
- perception of robots (2)
- perceptual reorganization (2)
- performance assessment (2)
- performance budget (2)
- performance information (2)
- performance measurement (2)
- periphyton (2)
- permittivity enhancement (2)
- permutation entropy (2)
- perovskite solar cell (2)
- person (2)
- personality change (2)
- personality traits (2)
- personhood (2)
- perspective taking (2)
- pesticides (2)
- phagocytosis (2)
- pharmacokinetics (2)
- phase behavior (2)
- phase dynamics (2)
- phase morphology (2)
- phase separation (2)
- phase transfer (2)
- phenolic compounds (2)
- phenology (2)
- phenprocoumon (2)
- phosphatidylserine (2)
- phosphorylase (2)
- photocatalysts (2)
- photochromism (2)
- photodehydro-Diels-Alder reaction (2)
- photoelectron (2)
- photogrammetry (2)
- photoisomerization (2)
- photoluminescence quenching (2)
- photon density wave spectroscopy (2)
- photonic crystals (2)
- photoswitches (2)
- photosynthetic rate (2)
- phreeqc (2)
- phylogenomics (2)
- physical inactivity (2)
- physical performance (2)
- physics education (2)
- physiological consequences (2)
- phytoplankton communities (2)
- pigment composition (2)
- pitch angle (2)
- planetary boundaries (2)
- planetary rings (2)
- planetary systems (2)
- planets and satellites: fundamental parameters (2)
- planets and satellites: general (2)
- plant architecture (2)
- plant cell wall (2)
- plant invasions (2)
- plant species richness (2)
- plant traits (2)
- plant volatiles (2)
- plant-soil (belowground) interactions (2)
- plasma density (2)
- plasma instabilities (2)
- plasmasphere (2)
- plasmaspheric hiss (2)
- plateau (2)
- platinum (2)
- plausibility (2)
- playa (2)
- pluvial floods (2)
- plyometric exercise (2)
- plyometrics (2)
- point clouds (2)
- polarity (2)
- policy advice (2)
- policy analysis (2)
- policy reform (2)
- policy-making (2)
- political ideology (2)
- political philosophy (2)
- politics (2)
- politische Ideologie (2)
- pollinator shift (2)
- poly(epsilon-caprolactone) (2)
- polyadenylation (2)
- polyampholytes (2)
- polycystic ovary syndrome (2)
- polyelectrolytes (2)
- polyester (2)
- polyesterurethanes (2)
- polymer degradation (2)
- polymersomes (2)
- polyphenols (2)
- polypropylene (2)
- polysemy (2)
- polystyrene-block-poly(4-vinylpyridine) (2)
- population cycles (2)
- population growth rate (2)
- population pharmacokinetics (2)
- population size (2)
- population structure (2)
- populations (2)
- pore pressure (2)
- porous silicon (2)
- positioning (2)
- positive solutions (2)
- possessives (2)
- post-natal (2)
- posttraumatic stress disorder (2)
- postural sway (2)
- potassium channel (2)
- power spectral analysis (2)
- pp-wave solutions (2)
- practice (2)
- pragmaticalisation (2)
- pre-activity (2)
- pre-natal (2)
- pre-school (2)
- pre-service teachers (2)
- preactivation (2)
- precaution (2)
- precision agriculture (2)
- predation (2)
- predation risk (2)
- predator (2)
- predictability (2)
- prediction error (2)
- predictive models (2)
- predictors (2)
- preference (2)
- preference assessment (2)
- preferential flow (2)
- prefixes (2)
- prefrontal cortex (2)
- preprocessing (2)
- preschool children (2)
- presidentialism (2)
- pressures (2)
- presupposition (2)
- prevalence information (2)
- price of anarchy (2)
- printing (2)
- privatization (2)
- proactive personality (2)
- proactive work behavior (2)
- probability (2)
- probability density function (2)
- probiotics (2)
- problem (2)
- problem-solving (2)
- problems (2)
- process (2)
- process mining (2)
- process modeling (2)
- process simulation (2)
- process-based modeling (2)
- processes (2)
- production control (2)
- professional (2)
- professional knowledge (2)
- professionalization (2)
- prognosis (2)
- proliferation (2)
- prolonged grief disorder (2)
- proper motions (2)
- property rights (2)
- prosocial (2)
- prosodic cues (2)
- prosody processing (2)
- prospective (2)
- protease inhibitors (2)
- protected area (2)
- protection motivation theory (2)
- protective factors (2)
- protein carbonyls (2)
- protein engineering (2)
- protein modification (2)
- protein search (2)
- protein translocation (2)
- protein-phenol interactions (2)
- protein-protein (2)
- proteomic analysis (2)
- proteostasis (2)
- protest (2)
- protonation (2)
- prototype-willingness-model (2)
- psychische Störungen (2)
- psycho-oncology (2)
- psychological detachment (2)
- psychological distress (2)
- psychological problems (2)
- psychological well-being (2)
- psychologinguistics (2)
- psychopathy (2)
- psychophysics (2)
- psychopower (2)
- psychosocial moderators (2)
- psychotherapeutic competencies (2)
- pubertal timing (2)
- puberty (2)
- public (2)
- public engagement (2)
- public good (2)
- public policy (2)
- pulling isometric muscle action (PIMA) (2)
- pulsars: individual: PSR B0833-45 (2)
- purification (2)
- qualitative content analysis (2)
- quantum (2)
- quantum field theory (2)
- quartz crystal microbalance (2)
- quasi-Fermi level splitting (2)
- queer (2)
- questioning solutions (2)
- radhard design (2)
- radial flow (2)
- radiation mechanisms: nonthermal (2)
- radiation therapy (2)
- radiative forcing (2)
- radiocarbon dating (2)
- radiogenic isotopes (2)
- radiosensitizers (2)
- rainfall (2)
- rainfall gradient (2)
- random diffusivity (2)
- random matrix theory (2)
- random-walks (2)
- randomized controlled trial (2)
- range dynamics (2)
- range of motion (2)
- range size (2)
- rank (2)
- rapid test kit (2)
- rare events (2)
- rate of perceived exertion (2)
- rate of torque development (2)
- ray tracing (2)
- reactance (2)
- reaction kinetics theory (2)
- reaction monitoring (2)
- reactive transport modeling (2)
- real-time (2)
- receiver function (2)
- reception studies (2)
- reciprocal class (2)
- reciprocal teaching (2)
- recollection (2)
- recollimation shocks (2)
- recombinant inbred line (2)
- recombination order (2)
- record (2)
- record linkage (2)
- recurrence analysis (2)
- redemption (2)
- redox homeostasis (2)
- redox polymers (2)
- redox processes (2)
- redox state (2)
- reduction (2)
- reed (2)
- reflexives (2)
- reforms (2)
- refugee youth (2)
- regional development (2)
- regional flood frequency analysis (2)
- regionalisation (2)
- register (2)
- regulations (2)
- regulatory T cells (2)
- regulatory physiology (2)
- reinforcement (2)
- relations (2)
- relationship (2)
- relationship constellations (2)
- relative pollen productivity (2)
- relaxation (2)
- remission (2)
- remote teaching (2)
- renormalization Hopf algebra (2)
- replacement (2)
- repository far-field (2)
- representation (2)
- reproducing kernel Hilbert space (2)
- reproductive strategies (2)
- reproductive success (2)
- resampling (2)
- research framework (2)
- research priorities (2)
- reservoir (2)
- reservoir characterization (2)
- resetting (2)
- resonance energy transfer (2)
- resonances (2)
- resource allocation (2)
- resource selection (2)
- restricted range (2)
- resurrection plants (2)
- retrogressive thaw slumps (2)
- revegetation (2)
- reward anticipation (2)
- rewards (2)
- rhizosphere (2)
- rhythm (2)
- rifting (2)
- ring current (2)
- ring current electrons (2)
- risk analysis (2)
- risk aversion (2)
- risk communication (2)
- risk governance (2)
- risk perceptions (2)
- risk reduction (2)
- risk-factors (2)
- risks (2)
- river erosion (2)
- river networks (2)
- rivers (2)
- rock (2)
- rock glacier (2)
- role-play (2)
- rolling averages (2)
- root morphology (2)
- root water uptake (2)
- rotational diffusion (2)
- rotifer (2)
- runners (2)
- running mechanics (2)
- rupture (2)
- rupturing of metal film (2)
- réchauffement planétaire (2)
- sACC (2)
- sadness (2)
- salamanders (2)
- salience (2)
- saliency (2)
- salinity (2)
- salinization (2)
- salivary alpha-amylase (2)
- salt (2)
- salt diffusion (2)
- salt pan (2)
- salt structures (2)
- sample preparation (2)
- sarcopenia (2)
- satellite data (2)
- satisfaction (2)
- savanna ecology (2)
- scaffolding (2)
- scalability (2)
- scanning tunneling microscopy (2)
- scenario analysis (2)
- scene perception (2)
- school learning (2)
- school mathematics (2)
- school quality (2)
- science (2)
- science mapping (2)
- scientific image (2)
- scoping review (2)
- scrambling (2)
- sculpture (2)
- sea level (2)
- sea level rise (2)
- second chambers (2)
- second language processing (2)
- secondary prevention (2)
- secular variation (2)
- sedentary (2)
- sediment core (2)
- sediment routing (2)
- sediment storage (2)
- sediment supply (2)
- sediment transport (2)
- sediment yield (2)
- sediments (2)
- seed (2)
- seed dispersal syndrome (2)
- seed provisioning (2)
- seismic monitoring (2)
- seismology (2)
- selective autophagy (2)
- selective laser melting (2)
- selective laser melting (SLM) (2)
- selenoprotein P (2)
- self threat (2)
- self-assembled monolayers (2)
- self-control (2)
- self-determination theory (2)
- self-evaluation (2)
- self-harm (2)
- self-isolation (2)
- self-objectification (2)
- self-organisation (2)
- self-regulated learning (2)
- self-report (2)
- self-similarity (2)
- semantic transparency (2)
- semi-arid hydrology (2)
- semi-parliamentary government (2)
- semiconducting polymers (2)
- semiconductor lasers (2)
- sensor (2)
- sensor alignment (2)
- sensor data (2)
- sensor fusion (2)
- sensors and actuators (2)
- sentence parsing (2)
- sentinel-1 (2)
- sequential data assimilation (2)
- serum (2)
- sexual aggression perpetration (2)
- sexual behavior (2)
- sexual coercion (2)
- sexual dimorphism (2)
- sexual reproduction (2)
- sexual self-esteem (2)
- sexual victimisation (2)
- shallow structure hypothesis (2)
- shieldings (TSNMRS) (2)
- short-read mapping (2)
- shortening (2)
- shotgun sequencing (2)
- shoulder (2)
- shrub-encroachment (2)
- sibilant (2)
- sign language (2)
- signal propagation (2)
- silver (2)
- silviculture (2)
- simplicity (2)
- simulation model (2)
- simulation-based (2)
- simultaneous bilingualism (2)
- single event transients (2)
- single-case experimental design (2)
- single-particle tracking (2)
- singularity (2)
- size (2)
- size distribution (2)
- skill (2)
- slope aspect (2)
- smart materials (2)
- soccer players (2)
- social class (2)
- social critique (2)
- social environment (2)
- social epistemology (2)
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- social movements (2)
- social network (2)
- social networking sites (2)
- social norms (2)
- social reactivity (2)
- social status (2)
- sociology (2)
- sodium hydroxide etching (2)
- soft actuators (2)
- soft errors (2)
- soft robotics (2)
- soft-templating (2)
- software development (2)
- soil fatigue (2)
- soil landscape (2)
- solar powered light-emitting diode (2)
- solubility (2)
- solvent vapor annealing (2)
- somatic variables (2)
- source parameters (2)
- source-sink dynamics (2)
- soy protein (2)
- space-charge stability (2)
- spacing (2)
- spatial autocorrelation (2)
- spatial heterogeneity (2)
- spatial scales (2)
- spatial vision (2)
- spatially explicit model (2)
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- species assembly (2)
- species distribution model (2)
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- specificity (2)
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- spectral analysis (2)
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- speech motor control (2)
- speech segmentation (2)
- speed-accuracy trade-off (2)
- speleothems (2)
- sphingomyelin (2)
- spider silk (2)
- spin transition (2)
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- spin-orbit interaction (2)
- split Hopkinson pressure bar (2)
- splitting (2)
- sport (2)
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- standards (2)
- starch granule initiation (2)
- starch granule surface (2)
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- starch morphology (2)
- starch synthase (2)
- stars: flare (2)
- stars: individual ([HD 36486]delta Ori A) (2)
- stars: individual (gamma Cassiopeiae) (2)
- stars: jets (2)
- stars: solar-type (2)
- stars: variables: Cepheids (2)
- starvation (2)
- state (2)
- statistical methods (2)
- stem cell adhesion (2)
- step selection (2)
- stereoselectivity (2)
- sterol (2)
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- task (2)
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- term (2)
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- thin film (2)
- thorium (2)
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- time averaging (2)
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- tissue (2)
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- tonoplast (2)
- topography (2)
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- trace (2)
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- use (2)
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- variance (2)
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- 0 (1)
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- 1 (1)
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Analysis of physicians' probability estimates of a medical outcome based on a sequence of events
(2022)
A basic law of probability is that the probability of a conjunction of 2 independent events is the product of both components and cannot exceed the likelihood of either component. When this basic law is violated, it is known as the conjunction fallacy. In clinical practice, the conjunction fallacy may arise when physicians estimate the probability of the overall outcome that requires >= 2 steps to be successful. For example, if a successful procedure requires the success of step A and step B, then the probability of overall success of the procedure cannot exceed the likelihood of success of either step A or step B. The aim of this study was to determine whether physicians could correctly estimate the overall probability of success from 2 independent events. <br /> This was a 3-part, Internet-based survey study designed to evaluate the presence of the conjunction fallacy in 2 separate obstetric contexts and 1 pulmonary context. Respondents were board-certified or board-eligible physicians in obstetrics and gynecology and pulmonary, recruited from a commercial survey service. In each context, physicians were presented with scenarios related to their medical specialty and asked to judge the probability of the overall outcome, or conjunction, and of the 2 individual events, or conjuncts. <br /> The first substudy, conducted April 2-4, 2021, described a delivery in brow presentation discovered during labor. To assess the overall probability of a successful spontaneous vaginal delivery, an obstetrician must consider the likelihood of the brow presentation converting to a deliverable position and the likelihood of vaginal delivery from the converted position. The second substudy, conducted November 2-11, 2021, described the diagnostic evaluation of pulmonary nodule discovered incidentally. To assess the overall probability that a biopsy reveals cancer, the physician must consider the likelihood that the nodule is cancerous and the likelihood that the biopsy successfully and accurately detects cancer. The third study, conducted May 13-19, 2021, modified the first substudy and asked responding obstetricians to consider the likelihood of the individual conjuncts before estimating the overall probability of successful vaginal delivery. <br /> The survey included responses from 215 physicians: 66% were male and 34% were female with a mean (SD) age of 53.6 (9.5) years and mean time since obtaining a medical degree of 27.5 (10.6) years. Overall, 78.1% of physicians committed the conjunction fallacy, estimating that the overall probability of success was greater than the likelihood of at least 1 of the 2 conjuncts. In the first substudy, 74.6% of 67 obstetricians committed the conjunction fallacy; respondents overestimated the combined probability by 12.8% (95% confidence interval [CI], 9.6%-16.1%), compared with the product of the 2 estimated conjuncts with statistically significant deviation (t66 = 7.94; P < 0.001; Cohen d = 0.97 [95% CI, 0.68-1.26]). In the second substudy, 86.9% of 84 pulmonologists committed the conjunction fallacy; respondents overestimated the combined probability by 19.8% (95% CI, 16.6%-23.0%), with statistically significant deviation of (t83 = 7.94; P < 0.001; Cohen d = 1.34 [95% CI, 1.04-1.64]). In the third substudy, 70.3% of 64 committed the conjunction fallacy; respondents overestimated the combined probability by 18.0% (95% CI, 13.4%-22.5%) with statistically significant deviation (t63 = 7.89; P < 0.001; Cohen d = 0.99 [95% CI, 0.68-1.28]). <br /> In this study, it was common for seasoned obstetricians and pulmonologists to commit the conjunction fallacy. Given that physicians often need to estimate the successful outcome of a multistep procedure, they may be doing so in a flawed manner that may negatively impact decision-making.
Diabetic foot ulcer (DFU) is a severe complication of diabetes and a challenging medical condition. Conventional treatments for DFU have not been effective enough to reduce the amputation rates, which urges the need for additional treatment. Stem cell-based therapy for DFU has been investigated over the past years. Its therapeutic effect is through promoting angiogenesis, secreting paracrine factors, stimulating vascular differentiation, suppressing inflammation, improving collagen deposition, and immunomodulation. It is controversial which type and origin of stem cells, and which administration route would be the most optimal for therapy. We reviewed the different types and origins of stem cells and routes of administration used for the treatment of DFU in clinical and preclinical studies. Diabetes leads to the impairment of the stem cells in the diseased patients, which makes it less ideal to use autologous stem cells, and requires looking for a matching donor. Moreover, angioplasty could be complementary to stem cell therapy, and scaffolds have a positive impact on the healing process of DFU by stem cell-based therapy. In short, stem cell-based therapy is promising in the field of regenerative medicine, but more studies are still needed to determine the ideal type of stem cells required in therapy, their safety, proper dosing, and optimal administration route.
The microstructure of permafrost ground contains clues to its formation and hence its preconditioning to future change.
We applied X-ray computed microtomography (CT) to obtain high-resolution data (Delta x = 50 mu m) of the composition of a 164 cm long permafrost core drilled in a Yedoma upland in north-eastern Siberia.
The CT analysis allowed the microstructures to be directly mapped and volumetric contents of excess ice, gas inclusions, and two distinct sediment types to be quantified. Using laboratory measurements of coarsely resolved core samples, we statistically estimated the composition of the sediment types and used it to indirectly quantify volumetric contents of pore ice, organic matter, and mineral material along the core.
We conclude that CT is a promising method for obtaining physical properties of permafrost cores which opens novel research potentials.
In contrast to molecular-dipole polymers, such as PVDF, ferroelectrets are a new class of flexible spatially heterogeneous piezoelectric polymers with dosed or open voids that act as deformable macro-dipoles after charging.
With a spectrum of manufacturing processes being developed to engineer the heterogeneous structures, ferroelectrets are made with attractive piezoelectric properties well-suited for applications, such as pressure sensors, acoustic transducers, etc.
However, the sources of the macro-dipole charges have usually been the same, microscopic dielectric barrier discharges within the voids, induced when the ferroelectrets are poled under a large electric field typically via a so-called corona poling, resulting in the separation and trapping of opposite charges into the interior walls of the voids.
Such a process is inherently self-limiting, as the reverse internal field from the macro-dipoles eventually extinguishes the microdischarges, resulting in limited density of ions and not too high overall piezoelectric performance. Here, a new method to form ferroelectrets with gigantic electroactivity is proposed and demonstrated with the aid of an external ion booster.
A laminate consisting of expanded polytetrafluoroethylene (ePTFE) and fluorinated-ethylene-propylene (FEP) was prefilled with bipolar ions produced externally by an ionizer and sequentially poled to force the separation of positive and negative ions into the open fibrous structure, rendering an impressive piezoelectric d(33)( )coefficient of 1600 pC/N-an improvement by a factor of 4 in comparison with the d(33) of a similar sandwich poled with nonenhanced corona poling.
The (pre)filling dearly increases the ion density in the open voids significantly. The charges stored in the open-cell structure stays at a high level for at least 4 months. In addition, an all-organic nanogenerator was made from an ePTFE-based ferroelectret, with conducting poly(3,4-ethylene dioxythiophene): poly(styrenesulfonate) (PEDOT: PSS) coated fabric electrodes.
When poled with this ion-boosting process, it yielded an output power twice that of a similar sample poled in a conventional corona-only process. The doubling in output power is mainly brought about by the significantly higher charge density achieved with the aid of external booster.
Furthermore, aside from the bipolar ions, extra monopolar ions can during the corona poling be blown into the open pores by using for instance a negative ionic hair dryer to produce a unipolar ePTFE-based ferroelectret with its d(33) coefficient enhanced by a factor of 3. Ion-boosting poling thus unleashes a new route to produce bipolar or unipolar open-cell ferroelectrets with highly enhanced piezoelectric response.
Hepatocytes secrete retinol-binding pro-tein 4 (RBP4) into circulation, thereby mobilizing vitamin A from the liver to provide retinol for extrahepatic tissues. Obesity and insulin resistance are associated with elevated RBP4 levels in the blood.
However, in a previous study, we observed that chronically increased RBP4 by forced Rbp4 expres-sion in the liver does not impair glucose homeostasis in mice.
Here, we investigated the effects of an acute mobilization of hepatic vitamin A stores by hepatic overexpression of RBP4 in mice.
We show that he-patic retinol mobilization decreases body fat content and enhances fat turnover. Mechanistically, we found that acute retinol mobilization increases hepatic expression and serum levels of fibroblast growth factor 21 (FGF21), which is regulated by retinol mobilization and retinoic acid in primary hepato-cytes.
Moreover, we provide evidence that the insulin-sensitizing effect of FGF21 is associated with organ-specific adaptations in retinoid homeostasis.
Taken together, our findings identify a novel cross-talk between retinoid homeostasis and FGF21 in mice with acute RBP4-mediated retinol mobilization from the liver.
For an effectively one-dimensional, semi-infinite disordered system connected to a reservoir of tracer particles kept at constant concentration, we provide the dynamics of the concentration profile.
Technically, we start with the Montroll-Weiss equation of a continuous time random walk with a scale-free waiting time density.
From this we pass to a formulation in terms of the fractional diffusion equation for the concentration profile C(x, t) in a semi-infinite space for the boundary condition C(0, t) = C-0, using a subordination approach.
From this we deduce the tracer flux and the so-called breakthrough curve (BTC) at a given distance from the tracer source.
In particular, BTCs are routinely measured in geophysical contexts but are also of interest in single-particle tracking experiments.
For the "residual' BTCs, given by 1- P(x, t), we demonstrate a long-time power-law behaviour that can be compared conveniently to experimental measurements.
For completeness we also derive expressions for the moments in this constant-concentration boundary condition.
Optics is a core field in the curricula of secondary physics education. In this study, we present the development and validation of a test instrument in the field of optics, the ray optics in converging lenses concept inventory (ROC-CI). It was developed for and validated with middle school students, but can also be adapted for the use in higher levels of physics education.
The ROC-CI can be used as a formative or a summative assessment of students' conceptual understanding of image formation by converging lenses, assessing the following: (i) the overall understanding of fundamental concepts related to converging lenses, (ii) the understanding of specific concepts, and (iii) students' propensity for difficulties within this topic.
The initial ROC-CI consists of 16 multiple-choice items; however, one item was removed based on various quality checks.
We validated the ROC-CI thoroughly with distractor analyses, classical test theory, item response theory, structural analyses, and analyses of students' total scores at different measurement points as quantitative approaches, as well as student interviews and an expert survey as qualitative approaches. The quantitative analyses are mostly based on a dataset of N 1/4 318 middle school students who took the ROC-CI as a post-test. The student interviews were conducted with seven middle school students after they were taught the concepts of converging lenses.
The expert survey included five experts who evaluated both individual items and the test as a whole.
The analyses showed good to excellent results for the test instrument, corroborating the 15-item ROC-CI's validity and its compliance with the three foci outlined above.
We estimate the source parameters of small-magnitude earthquakes that occurred during 2008-2020 in the Irpinia faults area (southern Italy).
We apply a spectral decomposition approach to isolate the source contribution from propagation and site effects for similar to 3000 earthquakes in the local magnitude range between M-L 0 and 4.2.
We develop our analyses in three steps. First, we fit the Brune (1970) model to the nonparametric source spectra to estimate corner frequency and seismic moment, and we map the spatial distribution of stress drop across the Irpinia area.
We found stress drops in the range 0.4-8.1 MPa, with earthquakes deeper than 7 km characterized by higher average stress drop (i.e., 3.2 MPa).
Second, assuming a simple stress-release model (kanamori and Heaton, 2000), we derive fracture energy and critical slip-weakening distance. The spatial variability of stress drop and fracture energy allows us to image the present stress conditions of fault segments activated during the 23 November 1980 M-s 6.9 earthquake.
The variability of the source parameters shows clear patterns of the fault mechanical properties, suggesting that the Irpinia fault system can be divided into three main sectors, with the northern and southern ones showing different properties from the central one.
Our results agree with previous studies indicating the presence of fluids with different composition in the different sectors of the Irpinia fault system. In the third step, we compare the time evolution of source parameters with a time series of geodetic displacement recorded near the fault system.
Temporal trends in the correlation between geodetic displacement and different source parameters indicate that the poroelastic deformation perturbation generated by the karst aquifer recharge is modulating not only the occurrence rate of micro-seismicity ( D' Agostino et al., 2018) but may lead to rupture asperities with different sizes and characteristics.