Refine
Year of publication
- 2019 (352) (remove)
Document Type
- Article (235)
- Doctoral Thesis (54)
- Other (27)
- Postprint (26)
- Review (7)
- Conference Proceeding (2)
- Habilitation Thesis (1)
Keywords
- biodiversity (7)
- climate change (6)
- animal personality (5)
- disturbance (4)
- global change (4)
- plant diversity (4)
- population dynamics (4)
- ABC transporter (3)
- ABCB7 (3)
- Arabidopsis (3)
- Arabidopsis thaliana (3)
- Baltic Sea (3)
- Biodiversität (3)
- Capsella (3)
- acid sphingomyelinase (3)
- carbon (3)
- coexistence (3)
- conservation genetics (3)
- crop production (3)
- cytotoxicity (3)
- dispersal (3)
- ecosystem services (3)
- edge effect (3)
- food webs (3)
- landscape diversity (3)
- local adaptation (3)
- molybdenum cofactor (3)
- movement ecology (3)
- natural habitats (3)
- nutrition (3)
- seed bank (3)
- species assembly (3)
- temperature (3)
- wetland vegetation (3)
- winter wheat (3)
- zinc (3)
- 2 Different Strains (2)
- Acacia mellifera (2)
- Africa (2)
- Amplicon sequencing (2)
- Animal personality (2)
- Beneficial mutations (2)
- Bewegungsökologie (2)
- Body-Size (2)
- Bombina bombina (2)
- Brachionus calyciflorus (2)
- COR15A (2)
- Carbon (2)
- Dictyostelium (2)
- Directional climate change (2)
- Egg Size (2)
- Escherichia coli (2)
- Europe (2)
- Evolution (2)
- Fire-bellied toad (2)
- HIREC (2)
- Individual-based models (2)
- Interspecific interactions (2)
- Klimawandel (2)
- Life-History Consequences (2)
- Limitation (2)
- Mixed mating (2)
- Movement ecology (2)
- Mutation rate (2)
- Mutator locus (2)
- NAC (2)
- Nighttime illumination (2)
- Nrf2 (2)
- Outcrossing (2)
- Outcrossing rate (2)
- Outdoor enclosure (2)
- Pex1 (2)
- Pex6 (2)
- Phylogeny (2)
- Polyunsaturated Fatty-Acids (2)
- Population-Growth (2)
- ProDisc Vivo (2)
- Pseudomonas aeruginosa (2)
- ROS (2)
- Recombination (2)
- Resource Competition (2)
- Respiration (2)
- Rodents (2)
- Rotifier (2)
- Räuber-Beute (2)
- Savannas (2)
- Walker A motif (2)
- Zebrafish (2)
- Zellweger (2)
- Zellweger syndrome spectrum disorder (ZSSD) (2)
- abiotic stress (2)
- acid ceramidase (2)
- activity (2)
- adaptation (2)
- amitriptyline (2)
- ancient DNA (2)
- ascorbate peroxidase (2)
- baltic sea (2)
- bank voles (2)
- behavioral flexibility (2)
- behavioral plasticity (2)
- biogeography (2)
- biomimetic sensors (2)
- body height (2)
- brackish waters (2)
- bryophytes (2)
- bush encroachment (2)
- butyrylcholinesterase (2)
- calcite (2)
- calcium carbonate inclusions (2)
- catalase (2)
- cell-free protein synthesis (2)
- chytridiomycota (2)
- classical swine fever (2)
- community ecology (2)
- community theory (2)
- compensatory dynamics (2)
- confocal microscopy (2)
- consumer diversity (2)
- coping styles (2)
- copper (2)
- costs (2)
- coviability analysis (2)
- cryptomycota (2)
- demographic noise (2)
- desiccation (2)
- distribution (2)
- diversity profiles (2)
- early-warning signals (2)
- eco-evolutionary experience (2)
- ecology (2)
- environmental noise (2)
- evolution (2)
- exploratory-behavior (2)
- extra-cytoplasmic pockets (2)
- forest management (2)
- fungal diversity (2)
- gene flow (2)
- glutathione (2)
- glutathione peroxidase (2)
- groundwater recharge (2)
- habitat connectivity (2)
- heterogeneity (2)
- hilly loes plateau (2)
- homeostasis (2)
- individual differences (2)
- individual-based model (2)
- individual-based modeling (2)
- influenza (2)
- inner-mongolia (2)
- intraspecific trait variation (2)
- intrinsically disordered proteins (2)
- iron (2)
- lamin (2)
- land sharing vs. land sparing (2)
- lichens (2)
- life‐history traits (2)
- lipid membranes (2)
- machine learning (2)
- male bank voles (2)
- maternal aggression (2)
- membranes (2)
- metabolic engineering (2)
- metabolic theory (2)
- microeukaryotes (2)
- mitogenome (2)
- modern coexistence theory (2)
- mojave desert (2)
- molecularly imprinted polymers (2)
- mustelid predation (2)
- mutation (2)
- myodes-glareolus (2)
- net primary productivity (2)
- network analysis (2)
- next-generation sequencing (2)
- niche partitioning (2)
- nitrous-oxide (2)
- o-phenylenediamine (2)
- offspring-defense (2)
- persulfide (2)
- phenotypic plasticity (2)
- photosynthesis (2)
- physical activity (2)
- plastic-associated biofilms (2)
- plasticity (2)
- polyethylene (2)
- polystyrene (2)
- polysulfide (2)
- population delimitation (2)
- population viability analysis (2)
- prairie vole (2)
- predation risk (2)
- predator-prey (2)
- predator-prey dynamics (2)
- protein-protein interactions (2)
- pyridoxal-50-phosphate (2)
- rain event depth (2)
- rapid evolution (2)
- recognition (2)
- regime shifts (2)
- reproductive strategies (2)
- respiration (2)
- resurrection plants (2)
- rivastigmine (2)
- rodents (2)
- rooting depth (2)
- salinity gradient (2)
- selenium (2)
- self-assembly (2)
- sexual species (2)
- shrub size (2)
- social information (2)
- spatial-distribution (2)
- species richness (2)
- stability (2)
- stable isotopes (2)
- stable states (2)
- storage (2)
- stress (2)
- structure (2)
- succulent karoo (2)
- sulfur-bacteria (2)
- superoxide dismutase (2)
- time series analysis (2)
- top-down control (2)
- trade-offs (2)
- vascular plants (2)
- viral matrix proteins (2)
- vole clethrionomys-glareolus (2)
- voles clethrionomys-glareolus (2)
- wild boar (2)
- wildlife corridors (2)
- zooplankton (2)
- Ökologie (2)
- "Optimal annual routine"-Modell (1)
- 16S rRNA gene sequencing (1)
- 2-deoxy-D-ribose-5-phoshphate aldolase (1)
- ABC Transporter (1)
- AMSTAR (1)
- AMSTAR 2 (1)
- Abies alba (1)
- Abiotic stress (1)
- Acer pseudoplatanus (1)
- Acinetobacter baumannii (1)
- Acoustic levitation (1)
- Actomyosin (1)
- Acute phase response (1)
- Adaptive dynamics (1)
- Adrenaline (1)
- Adrenochrome (1)
- Aeroponic cultivation (1)
- Aging (1)
- Agricultural landscape (1)
- Agricultural landscape generator (1)
- Alaska (1)
- Aldehyd (1)
- Aldehyd-oxidase (1)
- Aldehydoxidase (1)
- Algorithms (1)
- Alien species richness (1)
- Alternaria (1)
- Ambient pressure laser ionization (1)
- Amur River (1)
- Analysis (1)
- Anatomy (1)
- Ancient forest (1)
- Annual (1)
- Anpassung (1)
- Antarctica (1)
- Anthropocene (1)
- Aquatic fungi (1)
- Aquifers (1)
- Arbuscular mycorrhiza (1)
- Ascomyceten (1)
- Assay calibration (1)
- Assimilation efficiency (1)
- Atelerix albiventris (1)
- Atelerix algirus (1)
- Auskreuzungsrate (1)
- Aussterbeschuld (1)
- Australia (1)
- Autoimmune diagnostics (1)
- Auxin (1)
- Auxin transport (1)
- Auxotrophie (1)
- BEMOVI (1)
- BIOMEX (1)
- BMI (1)
- BMP (1)
- Bacterial biosensor (1)
- Bakterien (1)
- Base cations (1)
- Bayesian inference (1)
- Benzaldehyd (1)
- Bewegung (1)
- Biochemie (1)
- Biochemistry (1)
- Biodiversity (1)
- Biodiversity Exploratories (1)
- Biogeography (1)
- Biologicals (1)
- Biomarker (1)
- Bird prey (1)
- Bird species richness (1)
- Blm10 (1)
- Blütenduft (1)
- Bmp (1)
- Body perception (1)
- Body size (1)
- Body temperature (1)
- Botanik (1)
- Brachionus (1)
- CAM (1)
- CD spectroscopy (1)
- CDOM (1)
- CNL1 (1)
- CO2 concentration (1)
- CO2 conditions (1)
- CSD (1)
- Camelus bactrianus (1)
- Cardiac looping (1)
- Cardiovascular rehabilitation (1)
- Carex limosa (1)
- Carry-over-Effekte (1)
- Cattle (1)
- Cell extrusion (1)
- Childhood traits and disorders (1)
- Chlorenchyma (1)
- Chlorophyll (1)
- Cholesterol (1)
- Chopralla (1)
- Chromatin (1)
- Citrobacter rodentium (1)
- Climate change (1)
- Clinical trial (1)
- ClinicalTrials (1)
- Cloeodes complex (1)
- Clostridioides difficile (1)
- Coating (1)
- Coherence number (1)
- Coherent partition (1)
- Coiled coils (1)
- Coleoptera (1)
- Community (1)
- Community model (1)
- Community-weighted means (1)
- Competitive growth strategies (1)
- Computational biology and bioinformatics (1)
- Congo River (1)
- Conservation (1)
- Consortium (1)
- Coping styles (1)
- Coppice (1)
- Cross reactivity (1)
- Cultivated barley (1)
- DBD dye (1)
- DNA barcoding (1)
- DNA ejection (1)
- DNA origami (1)
- DNA viruses (1)
- DOC (1)
- DPE2 (1)
- Daphnia (1)
- Data quality (1)
- Database errors (1)
- Decomposition (1)
- Detection (1)
- Development (1)
- Diabetes (1)
- Direct electron transfer (1)
- Disturbance (1)
- Dosing algorithm (1)
- Dreischluchten-Stausee (1)
- Drought stress (1)
- Drugs (1)
- Dryopteridaceae (1)
- Dynamic sitting (1)
- EXPOSE-R2 (1)
- Echolocation (1)
- Ecological niche (1)
- Einwanderungskredit (1)
- Einzelmolekül-Kraftspektroskopie (1)
- Einzelmolekülkraftspektroskopie (1)
- Electropolymerization (1)
- Ellenberg indicator values (1)
- Encroachment (1)
- Energetik (1)
- Enzymkinetik (1)
- Epigenetic memory (1)
- Epigenetics (1)
- Epitope imprinting (1)
- Eschericha coli (1)
- Eubacterium ramulus (1)
- Euro plus Med PlantBase (1)
- European hare (1)
- Expansions-Mikroskopie (1)
- Extremophiles (1)
- F-box (1)
- FNR (1)
- FT-ICR MS (1)
- FTIR-ATR (1)
- FTO (1)
- Faecal glucocorticoid metabolites (1)
- Fagus sylvatica (1)
- Farber disease (1)
- Feature Engineering (1)
- Feeding rate (1)
- Field conditions (1)
- Field pattern (1)
- Fire frequency (1)
- First-generation migrant (1)
- Fisch (1)
- Flexibility (1)
- Fluorescence microscopy (1)
- Fluoreszenzmarkierung (1)
- Food intake (1)
- Forest species (1)
- Formaldehyd-Assimilierung (1)
- Formgedächtnispolymere (1)
- Fourier (1)
- Fragmentation (1)
- Fungal challenge (1)
- Fusarium (1)
- GBOL (1)
- GMP (1)
- GPCRs (1)
- GPS (1)
- GSNOR-GSNO reductase (1)
- Gas chromatography-mass spectrometry (GC-MS) (1)
- Gekkonidae (1)
- Gelbe Biotechnologie (1)
- Genetics (1)
- Genome assembly (1)
- Genomes (1)
- Gewässerökologie (1)
- Glyphosate (1)
- Graph partitions (1)
- Gross growth efficiency (1)
- Groundwater (1)
- Growth adjustment (1)
- Habitability (1)
- Habitat fragmentation (1)
- Habitat loss (1)
- Habitat selection (1)
- Heart development (1)
- Helarctos malayanus (1)
- Hemodynamics (1)
- Herbivorous insects (1)
- Heritability (1)
- High Power LED Array (1)
- High forest (1)
- Hochleistungs-LED-Array (1)
- Home range (1)
- HopZ1a (1)
- Humic acids (1)
- Hydrenchyma (1)
- Hydrology (1)
- IBD (1)
- Iberia (1)
- Impatiens (1)
- Individuen-basierende Modelle (1)
- Inert ingredients (1)
- Influenza A Viren (1)
- Influenza A virus (1)
- Innate immunity (1)
- Insekten (1)
- Intensive care (1)
- Inter-individual differences (1)
- Intraspecific competition (1)
- Intraspecific variation (1)
- Introgression Lines (1)
- Invertebrate pores (1)
- Ion optics (1)
- Ionmobility spectrometry (1)
- Isoenzyme (1)
- Isolation (1)
- Isthmus of Kra (1)
- Keratella cochlearis (1)
- Kernhülle (1)
- Kettle holes (1)
- Klick-Chemie (1)
- Koexistenz (1)
- Koexistenz unter wechselnden Bedingungen (1)
- Konnektivität (1)
- Krankheitsausbruch (1)
- Krankheitserreger (1)
- Krankheitsökologie (1)
- Lab-on-a-chip (1)
- Lake TaiHu (1)
- Lamin (1)
- Landnutzungshistorie (1)
- Landscape of fear (1)
- Landscape simulator (1)
- Landschaft der Angst (1)
- Landschaftsheterogenität (1)
- Langmuir-Blodgett films (1)
- Late embryogenesis abundant (1)
- Leaf cavitation (1)
- Leaf metabolism (1)
- Learning (1)
- Lebenszyklustheorie (1)
- Leguminosae (1)
- Lepus europaeus (1)
- Lichtanpassung (1)
- Life history traits (1)
- Limits of life (1)
- Locustella ochotensis (1)
- Lonchocarpus bussei (1)
- Lonchocarpus eriocalyx (1)
- Longitudinal (1)
- Low back pain (1)
- Lysiphlebus fabarum (1)
- MADS (1)
- MAMPs (1)
- Mars (1)
- Med-Checklist (1)
- Mediterranean (1)
- Metabolismus von Medikamenten (1)
- Metabolite QTL (1)
- Metabolite network (1)
- Metals (1)
- Methodological quality (1)
- Methylotrophie (1)
- Microbiology (1)
- Microsatellite (1)
- Middle East (1)
- Mikroheizung (1)
- Mikrostrukturierung (1)
- Mitochondrien (1)
- Modellierung (1)
- Molecular biology (1)
- Molybdän (1)
- Molybdänkofaktor (1)
- Monoclonal antibody (1)
- Monte Carlo method (1)
- Morphology (1)
- Morphometry (1)
- Myotis myotis (1)
- N (1)
- NE81 (1)
- NET (1)
- NIA1 (1)
- NIA2 (1)
- NOR (1)
- NOS-like activity (1)
- NQR (1)
- Na+ - NADH:quinone oxidoreductase (1)
- Nahrungsnetz (1)
- Network clustering (1)
- Neuritenwachstum (1)
- Neutral landscape model (1)
- Nicht-Zielorganismen (1)
- Nischen-Aufteilung (1)
- Nitrospirae (1)
- Nuclear magnetic resonance (1)
- Nutrient cycling (1)
- Nutritional quality (1)
- Nyctalus aviator (1)
- O-antigen specificity (1)
- Oberflächentemperatur (1)
- Office chair (1)
- Oocytes (1)
- Oomycetous pathogen (1)
- Oxidative stress (1)
- Oxidoreduktase (1)
- Ozeanversauerung (1)
- P ratios (1)
- PAMPs (1)
- PBS1 (1)
- PLP-Walker A-overlap (1)
- PLP-Walker A-Überlagerung (1)
- Pachycladon (1)
- PanTHERIA (1)
- Paraechinus aethiopicus (1)
- Peptide (1)
- Periplasma (1)
- Personality (1)
- Pestizide (1)
- Pflanzendiversitaet (1)
- Pflanzengemeinschaft (1)
- Pflanzenwissenschaften (1)
- Pharmacokinetics/pharmacodynamics (1)
- Pho1 (1)
- Pho2 (1)
- Phosphorus (1)
- Photosynthese (1)
- Photosäure (1)
- Phytohormone (1)
- Phytoplankton und Zooplankton (1)
- Picea abies (1)
- Pinus sylvestris (1)
- Plant functional traits (1)
- Plant signalling (1)
- Plant-soil feedback (1)
- Plastic surfaces (1)
- Plastizität (1)
- Polypodiales (1)
- Population genetics (1)
- Populationsdynamik (1)
- Porosity (1)
- Post-agricultural forest (1)
- Predator-prey interactions (1)
- Pressure distribution (1)
- Principal Investigator (1)
- ProDisc C (1)
- Process-based model (1)
- Proepicardium (1)
- Protein-Engineering (1)
- Protein-lipid interaction (1)
- Proteinmodifizierung (1)
- Pseudomonas syringae (1)
- Pseudotsuga menziesii (1)
- Quaternions (1)
- R (Programmiersprache) (1)
- RNA in situ hybridization (1)
- RNA-directed DNA methylation (1)
- RNA-seq (1)
- ROBIS (1)
- ROP (1)
- Redox marker (1)
- Renal function (1)
- Reproduction (1)
- Reproduktion (1)
- Rhodamin B (1)
- Rhodamine B (1)
- Rhodobacter capsulatus (1)
- Ribulose-Monophosphat-Weg (1)
- Risikoabschätzung (1)
- Risk avoidance behavior (1)
- Risk of bias (1)
- Rodent (1)
- Root hair (1)
- Rstats (1)
- Russian empire (1)
- Räuber-Beute Dynamiken (1)
- SAP (1)
- SCF complex (1)
- SOC (1)
- SPR (1)
- STERILE APETALA (1)
- Sahara-Sahel (1)
- Salmonella enterica (1)
- Salmonella myovirus (1)
- Sanger sequencing (1)
- Sargasso Sea (1)
- Scincidae (1)
- Sea barley (1)
- Secretion (1)
- Sediment (1)
- Selbstungssyndrom (1)
- Selective herbivory (1)
- Serin-Zyklus (1)
- Sf21 lysates (1)
- Shewanella (1)
- Sitting behaviour (1)
- SlTAF1 (1)
- Small mammal (1)
- Social group (1)
- Social network (1)
- Soil fertility (1)
- Soil function (1)
- Soil moisture (1)
- Sol-Gel (1)
- Specific dynamic action (1)
- Sphingosine (1)
- Staphylococcus aureus (1)
- Stoffwechselregulation (1)
- Stress (1)
- Stress recovery (1)
- Sun bear (1)
- Superoxide (1)
- Sus scrofa (1)
- Systematic review (1)
- T cell receptor (1)
- T(h)1 (1)
- T(h)17 (1)
- TRPC6 (1)
- TaiHu (1)
- Terminalia catappa (1)
- Thermometrie (1)
- Thickening (1)
- Three Gorges reservoir (1)
- Tomato (1)
- Torpor (1)
- Trade-offs zwischen funktionellen Eigenschaften (1)
- Trans-Golgi network (1)
- Trifluoroethanol (1)
- UV-B tolerance (1)
- Uredinopsis (1)
- Variation in funktionellen Eigenschaften (1)
- Vegetation structure (1)
- Ventilation (1)
- Verhaltens-Timing (1)
- Verhaltensökologie (1)
- Vibrio cholerae (1)
- VideoScan technology (1)
- Virus assembly (1)
- Vogelzug (1)
- Volatile organic compound (VOC) (1)
- Volta River (1)
- WD40 (1)
- Wasser (1)
- Wastewater (1)
- Water flow (1)
- Weather (1)
- Weißstorch (1)
- Wetland species (1)
- Wildschwein (1)
- Wnt (1)
- XFELs (1)
- YIP (1)
- Zell-Matrix-Wechselwirkung (1)
- Zelladhäsionskontrolle (1)
- Zellfreie Proteinsynthese (1)
- Zielkonflikte (1)
- Zinypr-1 (1)
- Zootoca vivipara (1)
- Zugvögel (1)
- Zymosan (1)
- abscisic acid (ABA) (1)
- acid ceramidase inhibitor ceranib-2 (1)
- acid phosphatase (1)
- adeno-associated-virus (1)
- admixture (1)
- adolescent growth (1)
- aerobic sports activity (1)
- agent-based model (1)
- agentenbasiertes Modell (1)
- aldehyde oxidase (1)
- allometry (1)
- alluvial soil (1)
- amino acids (1)
- anaerobic respiration (1)
- anchoring mechanism (1)
- and tissue-specificity (1)
- animal models (1)
- annexins (1)
- antheridiogens (1)
- anthropogenic interferences (1)
- anthropometry (1)
- antidepressants (1)
- antimikrobielle Peptide (1)
- antioxidant capacity (1)
- antisense transcription (1)
- apoplast (1)
- aquatic adaptation (1)
- aquatic-terrestrial interfaces (1)
- arenes (1)
- artificial protein binders (1)
- asymmetry of competition (1)
- atomic force microscopy (1)
- attraction-avoidance (1)
- autogamy (1)
- auxin (1)
- auxotrophy (1)
- bacteria (1)
- bacterial pathogenesis (1)
- bacterial toxins (1)
- bacteriophage (1)
- beeswax (1)
- beeswax substitutes (1)
- behavioural ecology (1)
- behavioural timing (1)
- benzaldehyde (1)
- beta-Lactams (1)
- beta-lactamase (1)
- biochemistry (1)
- biodiversity exploratories (1)
- bioenergetic model (1)
- biofilm (1)
- biological invasions (1)
- biomarker (1)
- bioremediation (1)
- bird migration (1)
- blebbing (1)
- body proportions (1)
- bog/mire plants (1)
- branched chain amino acids (1)
- buried horizon (1)
- calcium (1)
- canavanine (1)
- cancer immunotherapy (1)
- cancer markers (1)
- candelilla wax (1)
- canopy (1)
- capsid stability (1)
- carbon labeling (1)
- carbon nanotubes (CNTs) (1)
- carbon paper (1)
- carbon sinking flux (1)
- carbon uptake kinetics (1)
- carcasses (1)
- cardiovascular rehabilitation (1)
- carnauba wax (1)
- carry-over effects (1)
- carrying capacity (1)
- cell (1)
- cell adhesion control (1)
- cell viability assay (1)
- cell-ECM interactions (1)
- cellular antioxidant system (1)
- cellular forces (1)
- cellularization (1)
- centrality measures (1)
- centromere (1)
- centrosome (1)
- ceramide (1)
- cerebral cavernous malformations (1)
- cervical artificial disc replacement (1)
- cervical myelopathy (1)
- cervical total disc replacement (1)
- chemostat experiments (1)
- child growth (1)
- children (1)
- children and adolescents (1)
- chirality (1)
- cholesteryl ester (1)
- chromium (1)
- circadian rhythm (1)
- cleistogamy (1)
- cleptoparasitism (1)
- click chemistry (1)
- coastal dunes (1)
- coiled coil (1)
- coiled coils (1)
- colitis (1)
- colonization credit (1)
- community composition (1)
- community effect (1)
- community effect on height (1)
- computationally simulated epitopes (1)
- connectivity (1)
- conscripts (1)
- contergan (1)
- contractile tail (1)
- core shell UCNP (1)
- correlation (1)
- covariance (1)
- cryptic diversity (1)
- cryptic species (1)
- cyanobacteria (1)
- cytoglobin (1)
- dark diversity (1)
- decolorization (1)
- defense signaling pathways (1)
- diacylglycerol (1)
- digestive acclimation (1)
- direct electron transfer (1)
- disc arthroplasty (1)
- disease ecology (1)
- disease invasion (1)
- disease persistence (1)
- dispersal mortality (1)
- disturbance intensity (1)
- disturbance type (1)
- dndBCDE (1)
- drug metabolism (1)
- dry grasslands (1)
- dyes (1)
- dynamic energy budgets (1)
- eco-evolutionary feedbacks (1)
- ecological interactions (1)
- ecological modelling (1)
- ecological stoichiometry (1)
- ecological strategies (1)
- effective daylength (1)
- effectors (1)
- elicitors (1)
- empirical dynamic modelling (1)
- enantiospecificity (1)
- endosperm (1)
- endothelial cell (1)
- energetics (1)
- energy expenditure (1)
- environmental and general living conditions (1)
- enzymatic biofuel cell (1)
- enzymatically active membrane (1)
- enzyme immobilization (1)
- enzyme isoforms (1)
- enzyme kinetics (1)
- enzyme/polymer conjugate (1)
- epigenetics (1)
- epithionitrile (1)
- establishment (1)
- evolutionary rescue (1)
- exercise (1)
- expansion microscopy (1)
- experimental evolution (1)
- experimental plant communities (1)
- expression (1)
- expression Quantitative Trait Loci (1)
- expression profile (1)
- extinction (1)
- extinction debt (1)
- extracellular matrix (ECM) (1)
- extrazelluläre Matrix (1)
- feature engineering (1)
- fecundity (1)
- ferns (1)
- final height (1)
- fine-scale interactions (1)
- fire (1)
- fish (1)
- fitness gradient (1)
- flavanone (1)
- flavanonol (1)
- flavonoid (1)
- floral scent (1)
- flow cytometry (1)
- flower development (1)
- fluctuating light (1)
- fluktuierendes Licht (1)
- fluorescence (1)
- fluorescent labeling (1)
- fluorescent probe (1)
- fly pollination (1)
- food quality (1)
- food web (1)
- forecasting (1)
- forest conversion (1)
- formaldehyde assimilation (1)
- fossil pollen (1)
- fragmentation (1)
- free zinc (1)
- full annual cycle (1)
- functional complementation (1)
- functional traits (1)
- fungal community (1)
- funktionelle Eigenschaften (1)
- gamma diversity (1)
- gas chromatography-mass spectrometry (1)
- gene conversion (1)
- gene regulation (1)
- genetic circuits (1)
- genetics (1)
- genetische Netzwerke (1)
- geographic neighborhood (1)
- geometric morphometrics (1)
- germ pores (1)
- glacial divergence (1)
- glacial refugia (1)
- global change ecology (1)
- globaler Wandel (1)
- glucose 1-phosphate transport (1)
- glucosinolate hydrolysis (1)
- glycine cleavage system (1)
- glycobiology (1)
- gov (1)
- growth rate (1)
- guidelines (1)
- gynoecium development (1)
- habitat suitability (1)
- habitat use (1)
- health (1)
- heat shock proteins (1)
- height (1)
- helical structures (1)
- hemodynamics (1)
- hemoglobin (1)
- heterotopic ossification (HO) (1)
- heterotrophic bacteria (1)
- holotype (1)
- homogenization (1)
- host alternation (1)
- host-parasite interaction (1)
- human aldehyde oxidase (1)
- hybridization (1)
- hybridization barrier (1)
- hybridization rate (1)
- hydrocortisone (1)
- hymenoptera (1)
- hyperforin (1)
- hyperglycemia (1)
- immunotherapy (1)
- impact on growth (1)
- implant design (1)
- importance (1)
- importin (1)
- individual variability (1)
- inducible defence (1)
- infection risk (1)
- influenza A viruses (1)
- information theory (1)
- intake screening (1)
- integrative taxonomy (1)
- intensity vs (1)
- inter-individual differences (1)
- inter-specific interactions (1)
- interspecific hybridization (1)
- intestinal bacteria (1)
- introgression (1)
- invariability (1)
- invasion stages (1)
- invasive plant (1)
- inverted terminal repeat (ITR) (1)
- ion channel (1)
- ion homeostasis (1)
- iron regulation (1)
- iron-sulfur cluster (1)
- islands (1)
- isoflavone (1)
- karyopherin (1)
- klassische Schweinepest (1)
- lab-on-a-chip (1)
- land sharing vs (1)
- land sparing (1)
- land use history (1)
- land-use (1)
- land-use change (1)
- land-use intensity niche (1)
- landscape connectivity (1)
- landscape heterogeneity (1)
- landscape of fear (1)
- landscape scale (1)
- landscape structure (1)
- late embryogenesis abundant (1)
- latitudinal gradient (1)
- leading/trailing edge (1)
- leaf (1)
- leaf hydraulic architecture (1)
- leaf midrib (1)
- least-cost path (1)
- licht-schaltbare Proteine (1)
- life-history theory (1)
- life-history traits (1)
- limb disproportions (1)
- lipid droplets (1)
- lipid metabolism (1)
- lipid rafts (1)
- lipopolysaccharide (YLPS) (1)
- lokale Anpassung (1)
- loop modification (1)
- low and middle-income (1)
- low temperature (1)
- lyso-phospholipids (1)
- lysosomal storage disorders (1)
- machinelles Lernen (1)
- magpie (1)
- management (1)
- mass production process (1)
- maternal lineages (1)
- mathematical modeling (1)
- measles virus (1)
- mechanics (1)
- mechanische Stabilität (1)
- mechanistic model (1)
- mechanistisches Modell (1)
- membrane proteins (1)
- membrane repair (1)
- meta-analysis (1)
- metabolic Quantitative Trait Loci (1)
- metabolic regulation (1)
- metabolisches Engineering (1)
- metacommunity dynamics (1)
- methylotrophy (1)
- microbes (1)
- microclimate (1)
- microheating (1)
- microsomes (1)
- microstructures (1)
- migratory birds (1)
- mitochondria (1)
- mitochondrial DNA (1)
- mitochondrial genome (1)
- modelling (1)
- molecular evolution (1)
- molecular force sensors (1)
- molecular imprinting (1)
- molecular machine (1)
- molekulare Kraftsensoren (1)
- mortality bias (1)
- movement (1)
- movement behaviour (1)
- multi-adulteration (1)
- multidiversity (1)
- multidrug resistance (1)
- multivariate ratio analysis (1)
- museum collection (1)
- myoglobin (1)
- naringenin (1)
- natural killer cells (NK cells) (1)
- natural variation (1)
- nest-site selection (1)
- network (1)
- neurite outgrowth (1)
- neuroglobin (1)
- neuronal networks (1)
- neuronale Netzwerke (1)
- neutral sphingomyelinase-2 (1)
- new combination (1)
- new record (1)
- new species (1)
- nicht-kanonische Aminosäuren (1)
- nitrate assimilation (1)
- nitrated proteins (1)
- nitric oxide-NO (1)
- nitrile (1)
- nitrogen (1)
- nitrogen availability (1)
- nitrogen deposition (1)
- non-canonical amino acids (1)
- non-equilibrium coexistence (1)
- non-ripening (1)
- non-target organisms (1)
- nonproteinogenic amino acid (1)
- novel ecosystems (1)
- nuclear envelop (1)
- nuclear envelope (1)
- nuclear lamina (1)
- nuclear magnetic resonance (1)
- nuclear transport (1)
- nukleäre Lamina (1)
- obesity (1)
- occurrence estimates (1)
- ocean acidification (1)
- one-carbon metabolism (1)
- optimal annual routine model (1)
- optimal trait (1)
- ordinary differential equation (1)
- organ size (1)
- organic matter mineralization (1)
- outcrossing (1)
- outcrossing rate (1)
- oxygen affinity (1)
- pH (1)
- pPhytoplankton photoacclimation (1)
- palaeogenome (1)
- paraffin (1)
- parameter estimation (1)
- parental age (1)
- pathogen persistence (1)
- pathogens (1)
- peptides (1)
- percentage of fat mass (1)
- perennial (1)
- perfusion bioreactor (1)
- periodic flooding (1)
- permafrost (1)
- permutation entropy (1)
- persistence (1)
- pesticide (1)
- phage resistance (1)
- pharmacokinetics (1)
- phosphorus (1)
- phosphorus limitation (1)
- photo-induced (1)
- photoacid (1)
- photoactive proteins (1)
- photoactive yellow protein (PYP) (1)
- photoinduziert (1)
- photorespiration (1)
- phylogenetic regression (1)
- phylogeny (1)
- phytoplankton and zooplankton (1)
- phytoplankton composition (1)
- phytoplankton photoacclimation (1)
- plant community (1)
- plant development (1)
- plant functional traits (1)
- plant interactions (1)
- plant invasion (1)
- plant performance (1)
- plant science (1)
- plant-plant interactions (1)
- plasma membrane (1)
- pollen development (1)
- poly(A) polymerase (1)
- polyploidy (1)
- population differentiation (1)
- population growth rate (1)
- predator prey (1)
- predator-prey interaction (1)
- pressures (1)
- priming (1)
- priming effects (1)
- professional and amateur athletes (1)
- proline (1)
- proteasomal degradation (1)
- proteasome (1)
- proteasome storage granules (1)
- protein engineering (1)
- protein microcrystals (1)
- protein modification (1)
- protein recognition (1)
- proteoliposomes (1)
- pseudogene (1)
- pterocarpan (1)
- pump (1)
- quantile regression (1)
- quasi-permanent plot (1)
- random forest (1)
- range expansions (1)
- rangeland (1)
- re-survey (1)
- reaction norm (1)
- reactive nitrogen species (RNS) (1)
- reciprocal transplant experiment (1)
- recovery (1)
- reduced graphene oxide (1)
- reductase (1)
- remorin (1)
- reproduction (1)
- reproductive isolation (1)
- resetting (1)
- resistance (1)
- resonance energy transfer (1)
- resource allocation (1)
- ribulose monophosphate pathway (1)
- risk assessment (1)
- root and shoot competition (1)
- ruderal plant species (1)
- salt stress (1)
- sample delivery (1)
- saure Phosphatase (1)
- savanna ecology (1)
- schwach elektrische Fische (1)
- screen printed electrodes (SPEs) (1)
- seasonality (1)
- secular trend (1)
- sedimentary ancient DNA (1)
- seed development (1)
- seed morphology (1)
- sei whale (1)
- self-incompatibility (1)
- selfing syndrome (1)
- semi-arid savanna (1)
- senescence (1)
- serial femtosecond crystallography (1)
- serine cycle (1)
- serum (1)
- sex determination (1)
- sexual/asexual reproduction (1)
- shape-memory polymers (1)
- shifting baselines (1)
- shrub encroachment (1)
- siRNAs (1)
- simulation (1)
- single molecule force spectroscopy (1)
- single nucleotide polymorphism (1)
- single-molecule force spectroscopy (1)
- skeleton (1)
- social environment (1)
- socioeconomic status (1)
- soft actuators (1)
- soil bacterial diversity (1)
- sol-gel (1)
- space use (1)
- spatially induced variance (1)
- specialisation (1)
- specialized metabolites (1)
- speciation (1)
- species distribution model (1)
- species functional traits (1)
- species interactions (1)
- species niche (1)
- species-specific niche breadth (1)
- species-specific niche optima (1)
- specifier proteins (1)
- sphingolipids (1)
- sphingosine kinase (1)
- sphingosine kinase inhibitor SKI-II (1)
- starch metabolism (1)
- state and transition (1)
- statistical tools (1)
- stearic acid (1)
- step-selection function (1)
- sterols (1)
- stochastic dynamic programming (1)
- stochastisch-dynamische Optimierung (1)
- strength training (1)
- stress tolerance (1)
- structural biology (1)
- structural equation modeling (1)
- subtropical convergence zone (1)
- sugar transport (1)
- sulfite oxidase (1)
- sulphur metabolism (1)
- surface temperature (1)
- survival (1)
- switching function (1)
- sycamore maple (1)
- synthetic biology (1)
- tailspike protein (1)
- tallow (1)
- taxonomy (1)
- temperate (1)
- temperate forests (1)
- temperate grasslands (1)
- temperature increase (1)
- temperature variability (1)
- tetrahydrofolate (1)
- thalassoidism (1)
- thalidomide embryopathy (1)
- the Caucasus (1)
- theoretical ecology (1)
- theoretische Ökologie (1)
- thermal performance (1)
- thermometry (1)
- thermoplastic polymers (1)
- thermoplastischen Polymere (1)
- thermoresponsive Polymere (1)
- thermoresponsive polymers (1)
- threshold (1)
- time-resolved luminescence (1)
- tissue specificity (1)
- tomato (1)
- total conductive area (1)
- total disc replacement (1)
- trade-offs between functional traits (1)
- tradeoff (1)
- trait adaptation (1)
- trait variability (1)
- trait variation (1)
- transcortin (1)
- transcription factor (1)
- transcription factors (1)
- transcriptional interference (1)
- transcriptome (1)
- transporter (1)
- transposable elements (1)
- tree species diversity (1)
- tree-grass interactions (1)
- trifluoroethanol (1)
- triploid block (1)
- trnL-trnF (1)
- tropical (1)
- tropical freshwater fish (1)
- tropische Süßwasser Fische (1)
- tumor immunity (1)
- tumor microenvironment (1)
- tumor-associated macrophage (1)
- type-3 secretion (1)
- ubiquitin (1)
- unbalanced diets (1)
- vegan (1)
- vegetarian (1)
- vegetation dynamics (1)
- verzweigtkettige Aminosäuren (1)
- vessel diameter (1)
- vessel number (1)
- vollständiger Jahreszyklus (1)
- water (1)
- weakly electric fish (1)
- weiche Aktuatoren (1)
- wet grasslands (1)
- white stork (1)
- wildlife disease (1)
- xanthine oxidase (1)
- yedoma (1)
- zebrafish (1)
- zebularine (1)
- zelluläre Kräfte (1)
- ökologische Modellierung (1)
Institute
- Institut für Biochemie und Biologie (352) (remove)
NK cells have emerged as promising candidates for cancer immunotherapy, especially due to their ability to fight circulating tumor cells thereby preventing metastases formation. Hence several studies have been performed to generate and expand highly cytotoxic NK cells ex vivo, e.g., by using specific cytokines to upregulate both their proliferation and surface expression of distinct activating receptors. Apart from an enhanced activity, application of NK cells as immunotherapeutic agent further requires sufficient cell numbers and a high purity. All these parameters depend on a variety of different factors including the starting material, additives like cytokines as well as the culture system. Here we analyzed PBMC-derived NK cells of five anonymized healthy donors expanded under specific conditions in an innovative perfusion bioreactor system with respect to their phenotype, IFN gamma production, and cytotoxicity in vitro. Important features of the meander type bioreactors used here are a directed laminar flow of medium and control of relevant process parameters. Cells are cultivated under "steady state" conditions in perfusion mode. Our data demonstrate that expansion of CD3(+) T cell depleted PBMCs in our standardized system generates massive amounts of highly pure (>85%) and potent anticancer active NK cells. These cells express a variety of important receptors driving NK cell recruitment, adhesion as well as activation. More specifically, they express the chemokine receptors CXCR3, CXCR4, and CCR7, the adhesion molecules L-selectin, LFA-1, and VLA-4, the activating receptors NKp30, NKp44, NKp46, NKG2D, DNAM1, and CD16 as well as the death ligands TRAIL and Fas-L. Moreover, the generated NK cells show a strong IFN gamma expression upon cultivation with K562 tumor cells and demonstrate a high cytotoxicity toward leukemic as well as solid tumor cell lines in vitro. Altogether, these characteristics promise a high clinical potency of thus produced NK cells awaiting further evaluation.
Ecological communities are undeniably diverse, both in terms of the species that compose them as well as the type of interactions that link species to each other. Despite this long recognition of the coexistence of multiple interaction types in nature, little is known about the consequences of this diversity for community functioning. In the ongoing context of global change and increasing species extinction rates, it seems crucial to improve our understanding of the drivers of the relationship between species diversity and ecosystem functioning. Here, using a multispecies dynamical model of ecological communities including various interaction types (e.g. competition for space, predator interference, recruitment facilitation in addition to feeding), we studied the role of the presence and the intensity of these interactions for species diversity, community functioning (biomass and production) and the relationship between diversity and functioning. Taken jointly, the diverse interactions have significant effects on species diversity, whose amplitude and sign depend on the type of interactions involved and their relative abundance. They however consistently increase the slope of the relationship between diversity and functioning, suggesting that species losses might have stronger effects on community functioning than expected when ignoring the diversity of interaction types and focusing on feeding interactions only.
Zinc is an essential trace element, making it crucial to have a reliable biomarker for evaluating an individual’s zinc status. The total serum zinc concentration, which is presently the most commonly used biomarker, is not ideal for this purpose, but a superior alternative is still missing. The free zinc concentration, which describes the fraction of zinc that is only loosely bound and easily exchangeable, has been proposed for this purpose, as it reflects the highly bioavailable part of serum zinc. This report presents a fluorescence-based method for determining the free zinc concentration in human serum samples, using the fluorescent probe Zinpyr-1. The assay has been applied on 154 commercially obtained human serum samples. Measured free zinc concentrations ranged from 0.09 to 0.42 nM with a mean of 0.22 ± 0.05 nM. It did not correlate with age or the total serum concentrations of zinc, manganese, iron or selenium. A negative correlation between the concentration of free zinc and total copper has been seen for sera from females. In addition, the free zinc concentration in sera from females (0.21 ± 0.05 nM) was significantly lower than in males (0.23 ± 0.06 nM). The assay uses a sample volume of less than 10 µL, is rapid and cost-effective and allows us to address questions regarding factors influencing the free serum zinc concentration, its connection with the body’s zinc status, and its suitability as a future biomarker for an individual’s zinc status.
Domestic Bactrian camel (Camelus bactrianus) used to be one of the most important livestock species in Chinese history, as well as the major transport carrier on the ancient Silk Road. However, archeological studies on Chinese C. bactrianus are still limited, and molecular biology research on this species is mainly focused on modern specimens. In this study, we retrieved the complete mitochondrial genome from a C. bactrianus specimen, which was excavated from northwestern China and dated at 1290-1180 cal. Phylogenetic analyses using 18 mitochondrial genomes indicated that the C. bactrianus clade was divided into two maternal lineages. The majority of samples originating from Iran to Japan and Mongolia belong to subclade A1, while our sample together with two Mongolian individuals formed the much smaller subclade A2. Furthermore, the divergence time of these two maternal lineages was estimated as 165 Kya (95% credibility interval 117-222 Kya), this might indicate that several different evolutionary lineages were incorporated into the domestic gene pool during the initial domestication process. Bayesian skyline plot (BSP) analysis a slow increase in female effective population size of C. bactrianus from 5000 years ago, which to the beginning of domestication of C. bactrianus. The present study also revealed that there were extensive exchanges of genetic information among C. bactrianus populations in regions along the Silk Road.
A new isoflavone, 4′-prenyloxyvigvexin A (1) and a new pterocarpan, (6aR,11aR)-3,8-dimethoxybitucarpin B (2) were isolated from the leaves of Lonchocarpus bussei and the stem bark of Lonchocarpus eriocalyx, respectively. The extract of L. bussei also gave four known isoflavones, maximaisoflavone H, 7,2′-dimethoxy-3′,4′-methylenedioxyisoflavone, 6,7,3′-trimethoxy-4′,5′-methylenedioxyisoflavone, durmillone; a chalcone, 4-hydroxylonchocarpin; a geranylated phenylpropanol, colenemol; and two known pterocarpans, (6aR,11aR)-maackiain and (6aR,11aR)-edunol. (6aR,11aR)-Edunol was also isolated from the stem bark of L. eriocalyx. The structures of the isolated compounds were elucidated by spectroscopy. The cytotoxicity of the compounds was tested by resazurin assay using drug-sensitive and multidrug-resistant cancer cell lines. Significant antiproliferative effects with IC50 values below 10 μM were observed for the isoflavones 6,7,3′-trimethoxy-4′,5′-methylenedioxyisoflavone and durmillone against leukemia CCRF-CEM cells; for the chalcone, 4-hydroxylonchocarpin and durmillone against its resistant counterpart CEM/ADR5000 cells; as well as for durmillone against the resistant breast adenocarcinoma MDA-MB231/BCRP cells and resistant gliobastoma U87MG.ΔEGFR cells.
A yeast expression plasmid was constructed containing a cardenolide biosynthetic module, referred to as CARD II, using the AssemblX toolkit, which enables the assembly of large DNA constructs. The genes cloned into the vector were (a) a Δ5‐3β‐hydroxysteroid dehydrogenase gene from Digitalis lanata, (b) a steroid Δ5‐isomerase gene from Comamonas testosteronii, (c) a mutated steroid‐5β‐reductase gene from Arabidopsis thaliana, and (d) a steroid 21‐hydroxylase gene from Mus musculus. A second plasmid bearing an ADR/ADX fusion gene from Bos taurus was also constructed. A Saccharomyces cerevisiae strain bearing these two plasmids was generated. This strain, termed “CARD II yeast”, was capable of producing 5β‐pregnane‐3β,21‐diol‐20‐one, a central intermediate in 5β‐cardenolide biosynthesis, starting from pregnenolone which was added to the culture medium. Using this approach, five consecutive steps in cardenolide biosynthesis were realized in baker's yeast.
Increasing air temperature and atmospheric CO2 levels may affect the distribution of invasive species. Whereas there is wide knowledge on the effect of global change on temperate species, responses of tropical invasive species to these two global change drivers are largely unknown. We conducted a greenhouse experiment on Terminalia catappa L. (Combretaceae), an invasive tree species on Brazilian coastal areas, to evaluate the effects of increased air temperature and CO2 concentration on seed germination and seedling growth on the island of Santa Catarina (Florianopolis, Brazil). Seeds of the invasive tree were subjected to two temperature levels (ambient and +1.6 degrees C) and two CO2 levels (ambient and 650 ppmv) with a factorial design. Increased temperature enhanced germination rate and shortened germination time of T. catappa seeds. It also increased plant height, number of leaves and above-ground biomass. By contrast, increased atmospheric CO2 concentration had no significant effects, and the interaction between temperature and CO2 concentration did not affect any of the measured traits. Terminalia catappa adapts to a relatively broad range of environmental conditions, being able to tolerate cooler temperatures in its invasive range. As T. catappa is native to tropical areas, global warming might favour its establishment along the coast of subtropical South America, while increased CO2 levels seem not to have significant effects on seed germination or seedling growth.
When added to endurance training, dynamic strength training leads to significantly greater improvements in peripheral muscle strength and power output in patients with cardiovascular disease, which may be relevant to enhance the patient’s prognosis. As a result, dynamic strength training is recommended in the rehabilitative treatment of many different cardiovascular diseases. However, what strength training intensity should be selected remains under intense debate. Evidence is nonetheless emerging that high-intensity strength training (≥70% of one-repetition maximum) is more effective to increase acutely myofibrillar protein synthesis, cause neural adaptations and, in the long term, increase muscle strength, when compared to low-intensity strength training. Moreover, multiple studies report that high-intensity strength training causes fewer increments in (intra-)arterial blood pressure and cardiac output, as opposed to low-intensity strength training, thus potentially pointing towards sufficient medical safety for the cardiovascular system. The aim of this systematic review is therefore to discuss this line of evidence, which is in contrast to current clinical practice, and to re-open the debate as to what dynamic strength training intensities should actually be applied.