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- Juvenile hormone (2)
- Biological activity (1)
- Biosynthesis (1)
- Corpora allata (1)
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- Enzyme inhibitor (1)
- In vitro (1)
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- Leptinotarsa decemlineata (1)
- Orthoptera (1)
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Institute
Sinefungin inhibited the S-adenosylmethionine-dependent farnesoic acid methyltransferase in a cell-free system containing a homogenate of corpora allata from female locusts, Locusta migratoria. The enzyme catalyzed the penultimate step of juvenile hormone biosynthesis in the insects. Culturing corpora allata in the presence of sinefungin greatly suppressed juvenile hormone production. The following in vivo effects were visible after injection of the inhibitor: increase in mortality and reduction of total haemolymph protein liter and ovary fresh weight, as well as length of terminal oocytes. Attempts to reverse these effects by topical application of the juvenile hormone analog ZR-515 (methoprene) were only partly successful. Therefore, the in vivo effects may be due to a general inhibition of methyltransferase enzymes in the insect. Sinefungin appeared to be of potential interest as the first representative of a new class of insect growth regulators.
In einer empirischen Querschnittsstudie mit exemplarischem Charakter werden Rückschüler (Förderschüler) der Schule für Lernbehinderte (N = 26) und vier jahrgangsentsprechende Hauptschulgruppen (N = 98) in den Faktoren Erfolgs- und Mrßerfolgsattribuierung, Angst, Schulleistung und Intelligenz vergleichend untersucht. Während im affektiven Bereich ein negatives Begabungsselbstkonzept und eine erhöhte Neigung zu ängstlichem Verhalten bei den Rückschülern nachgewiesen wird, zeigen sich im Schulleistungsbereich günstigere Ergebnisse für die Förderschüler der SfL. Die Intelligenzwerte der Rückschüler liegen deutlich unter denen der Hauptschüler. Die Ergebnisse werden hinsichtlich ihrer möglichen Hintergründe und der Konsequenzen für die Schule für Lernbehinderte diskutiert.
Criticisms of the integration of psychotherapy-outcome research performed by Smith, Glass, and Miller (1980) are reviewed and answered. An attempt is made to account for the conflicting points of view in this disagreement in terms of certain issues that have engaged philosophers of science in the 20th century. It is hoped that, in passing, something useful is learned about research of many types on psychotherapy.