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DNA origami nanostructures allow for the arrangement of different functionalities such as proteins, specific DNA structures, nanoparticles, and various chemical modifications with unprecedented precision. The arranged functional entities can be visualized by atomic force microscopy (AFM) which enables the study of molecular processes at a single-molecular level. Examples comprise the investigation of chemical reactions, electron-induced bond breaking, enzymatic binding and cleavage events, and conformational transitions in DNA. In this paper, we provide an overview of the advances achieved in the field of single-molecule investigations by applying atomic force microscopy to functionalized DNA origami substrates.
Biosensors for the detection of benzaldehyde and g-aminobutyric acid (GABA) are reported using aldehyde oxidoreductase PaoABC from Escherichia coli immobilized in a polymer containing bound low potential osmium redox complexes. The electrically connected enzyme already electrooxidizes benzaldehyde at potentials below −0.15 V (vs. Ag|AgCl, 1 M KCl). The pH-dependence of benzaldehyde oxidation can be strongly influenced by the ionic strength. The effect is similar with the soluble osmium redox complex and therefore indicates a clear electrostatic effect on the bioelectrocatalytic efficiency of PaoABC in the osmium containing redox polymer. At lower ionic strength, the pH-optimum is high and can be switched to low pH-values at high ionic strength. This offers biosensing at high and low pH-values. A “reagentless” biosensor has been formed with enzyme wired onto a screen-printed electrode in a flow cell device. The response time to addition of benzaldehyde is 30 s, and the measuring range is between 10–150 µM and the detection limit of 5 µM (signal to noise ratio 3:1) of benzaldehyde. The relative standard deviation in a series (n = 13) for 200 µM benzaldehyde is 1.9%. For the biosensor, a response to succinic semialdehyde was also identified. Based on this response and the ability to work at high pH a biosensor for GABA is proposed by coimmobilizing GABA-aminotransferase (GABA-T) and PaoABC in the osmium containing redox polymer.
Polen trat am 1. Mai 2004 der Europäischen Union bei. Artikel 4 der Akte über die Bedingungen des Beitritts bestimmt, dass jeder neue Mitgliedstaat ab dem Tag seines Beitritts als Mitgliedstaat, für den eine Ausnahmeregelung im Sinne des Artikels 139 AEUV1 gilt, an der Wirtschafts- und Währungsunion teilnimmt. Das bedeutet für Polen langfristig die Notwendigkeit, die Gemeinschaftswährung Euro zu übernehmen.
This reference paper describes the sampling and contents of the IZA Evaluation Dataset Survey and outlines its vast potential for research in labor economics. The data have been part of a unique IZA project to connect administrative data from the German Federal Employment Agency with innovative survey data to study the out-mobility of individuals to work. This study makes the survey available to the research community as a Scientific Use File by explaining the development, structure, and access to the data. Furthermore, it also summarizes previous findings with the survey data.
Historiografie und Publizistik haben den Kriegsausbruch von 1914 immer aus unterschiedlichen Blickwinkeln und mit wechselnden Intentionen behandelt. Dabei wurde deutlich, dass sich mit der Überwindung der nationalen Perspektive auf 1914 zugleich auch unser Blick auf die Verantwortlichkeit der einzelnen europäischen Regierungen erweitert hat. Damit ist die Kriegsschuldfrage, die gleich am Anfang der Debatte um 1914 gestanden hatte und gerade nach den Pariser Vorortverträgen instrumentalisiert worden war, eigentlich obsolet geworden und einer Perspektive gewichen, die, frei von tagespolitischen Belastungen, nationalen Feindbildern und Vorurteilen, Schuld und Verantwortung in ihren Verschränkungen mit dem politischen Entscheidungshandeln verdeutlicht und dabei auch die systemischen Voraussetzungen und Folgen in Rechnung stellt.
This study investigates whether number dissimilarities on subject and object DPs facilitate the comprehension of subject-and object-extracted centre-embedded relative clauses in children with Grammatical Specific Language Impairment (G-SLI). We compared the performance of a group of English-speaking children with G-SLI (mean age: 12; 11) with that of two groups of younger typically developing (TD) children, matched on grammar and receptive vocabulary, respectively. All groups were more accurate on subject-extracted relative clauses than object-extracted ones and, crucially, they all showed greater accuracy for sentences with dissimilar number features (i.e., one singular, one plural) on the head noun and the embedded DP. These findings are interpreted in the light of current psycholinguistic models of sentence comprehension in TD children and provide further insight into the linguistic nature of G-SLI.