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Industry 4.0 and the Internet of Things are recent developments that have lead to the creation of new kinds of manufacturing data. Linking this new kind of sensor data to traditional business information is crucial for enterprises to take advantage of the data’s full potential. In this paper, we present a demo which allows experiencing this data integration, both vertically between technical and business contexts and horizontally along the value chain. The tool simulates a manufacturing company, continuously producing both business and sensor data, and supports issuing ad-hoc queries that answer specific questions related to the business. In order to adapt to different environments, users can configure sensor characteristics to their needs.
Merchants on modern e-commerce platforms face a highly competitive environment. They compete against each other using automated dynamic pricing and ordering strategies. Successfully managing both inventory levels as well as offer prices is a challenging task as (i) demand is uncertain, (ii) competitors strategically interact, and (iii) optimized pricing and ordering decisions are mutually dependent. We show how to derive optimized data-driven pricing and ordering strategies which are based on demand learning techniques and efficient dynamic optimization models. We verify the superior performance of our self-adaptive strategies by comparing them to different rule-based as well as data-driven strategies in duopoly and oligopoly settings. Further, to study and to optimize joint dynamic ordering and pricing strategies on online marketplaces, we built an interactive simulation platform. To be both flexible and scalable, the platform has a microservice-based architecture and allows handling dozens of competing merchants and streams of consumers with configurable characteristics.
High-throughput RNA sequencing produces large gene expression datasets whose analysis leads to a better understanding of diseases like cancer. The nature of RNA-Seq data poses challenges to its analysis in terms of its high dimensionality, noise, and complexity of the underlying biological processes. Researchers apply traditional machine learning approaches, e. g. hierarchical clustering, to analyze this data. Until it comes to validation of the results, the analysis is based on the provided data only and completely misses the biological context. However, gene expression data follows particular patterns - the underlying biological processes. In our research, we aim to integrate the available biological knowledge earlier in the analysis process. We want to adapt state-of-the-art data mining algorithms to consider the biological context in their computations and deliver meaningful results for researchers.
The advance of high-throughput RNA-Sequencing techniques enables researchers to analyze the complete gene activity in particular cells. From the insights of such analyses, researchers can identify disease-specific expression profiles, thus understand complex diseases like cancer, and eventually develop effective measures for diagnosis and treatment. The high dimensionality of gene expression data poses challenges to its computational analysis, which is addressed with measures of gene selection. Traditional gene selection approaches base their findings on statistical analyses of the actual expression levels, which implies several drawbacks when it comes to accurately identifying the underlying biological processes. In turn, integrative approaches include curated information on biological processes from external knowledge bases during gene selection, which promises to lead to better interpretability and improved predictive performance. Our work compares the performance of traditional and integrative gene selection approaches. Moreover, we propose a straightforward approach to integrate external knowledge with traditional gene selection approaches. We introduce a framework enabling the automatic external knowledge integration, gene selection, and evaluation. Evaluation results prove our framework to be a useful tool for evaluation and show that integration of external knowledge improves overall analysis results.