Filtern
Volltext vorhanden
- nein (1)
Erscheinungsjahr
- 2015 (1)
Dokumenttyp
- Wissenschaftlicher Artikel (1) (entfernen)
Sprache
- Englisch (1)
Gehört zur Bibliographie
- ja (1)
Schlagworte
- directed evolution (1)
- fluorescent reporter (1)
- optogenetics (1)
Institut
- Institut für Biochemie und Biologie (1) (entfernen)
Light-switchable proteins offer numerous opportunities as tools for manipulating biological systems with exceptional degrees of spatiotemporal control. Most designed light-switchable proteins currently in use have not been optimised using the randomisation and selection/screening approaches that are widely used in other areas of protein engineering. Here we report an approach for screening light-switchable DNA-binding proteins that relies on light-dependent repression of the transcription of a fluorescent reporter. We demonstrate that the method can be used to recover a known light-switchable DNA-binding protein from a random library.