Refine
Has Fulltext
- yes (2)
Document Type
- Postprint (2) (remove)
Language
- English (2)
Is part of the Bibliography
- yes (2)
Keywords
- acid (1)
- complexes (1)
- conformational-changes (1)
- continuous-flow (1)
- efficient (1)
- light (1)
- microscopy (1)
- phenanthrenes (1)
- photochemical synthesis (1)
- protein-kinase inhibitors (1)
Institute
The synthesis and photophysical properties of two new FRET pairs based on coumarin as a donor and DBD dye as an acceptor are described. The introduction of a bromo atom dramatically increases the two-photon excitation (2PE) cross section providing a 2PE-FRET system, which is also suitable for 2PE-FLIM.
Continuous synthesis of pyridocarbazoles and initial photophysical and bioprobe characterization
(2013)
Pyridocarbazoles when ligated to transition metals yield high affinity kinase inhibitors. While batch photocyclizations enable the synthesis of these heterocycles, the non-oxidative Mallory reaction only provides modest yields and difficult to purify mixtures. We demonstrate here that a flow-based Mallory cyclization provides superior results and enables observation of a clear isobestic point. The flow method allowed us to rapidly synthesize ten pyridocarbazoles and for the first time to document their interesting photophysical attributes. Preliminary characterization reveals that these molecules might be a new class of fluorescent bioprobe.