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Merchants on modern e-commerce platforms face a highly competitive environment. They compete against each other using automated dynamic pricing and ordering strategies. Successfully managing both inventory levels as well as offer prices is a challenging task as (i) demand is uncertain, (ii) competitors strategically interact, and (iii) optimized pricing and ordering decisions are mutually dependent. We show how to derive optimized data-driven pricing and ordering strategies which are based on demand learning techniques and efficient dynamic optimization models. We verify the superior performance of our self-adaptive strategies by comparing them to different rule-based as well as data-driven strategies in duopoly and oligopoly settings. Further, to study and to optimize joint dynamic ordering and pricing strategies on online marketplaces, we built an interactive simulation platform. To be both flexible and scalable, the platform has a microservice-based architecture and allows handling dozens of competing merchants and streams of consumers with configurable characteristics.
Electronic health is one of the most popular applications of information and communication technologies and it has contributed immensely to health delivery through the provision of quality health service and ubiquitous access at a lower cost. Even though this mode of health service is increasingly becoming known or used in developing nations, these countries are faced with a myriad of challenges when implementing and deploying e-health services on both small and large scale. It is estimated that the Africa population alone carries the highest percentage of the world’s global diseases despite its certain level of e-health adoption. This paper aims at analyzing the progress so far and the current state of e-health in developing countries particularly Africa and propose a framework for further improvement.
A significant percentage of urban traffic is caused by the search for parking spots. One possible approach to improve this situation is to guide drivers along routes which are likely to have free parking spots. The task of finding such a route can be modeled as a probabilistic graph problem which is NP-complete. Thus, we propose heuristic approaches for solving this problem and evaluate them experimentally. For this, we use probabilities of finding a parking spot, which are based on publicly available empirical data from TomTom International B.V. Additionally, we propose a heuristic that relies exclusively on conventional road attributes. Our experiments show that this algorithm comes close to the baseline by a factor of 1.3 in our cost measure. Last, we complement our experiments with results from a field study, comparing the success rates of our algorithms against real human drivers.
Internet connectivity of cloud services is of exceptional importance for both their providers and consumers. This article demonstrates the outlines of a method for measuring cloud-service connectivity at the internet protocol level from a client's perspective. For this, we actively collect connectivity data via traceroute measurements from PlanetLab to several major cloud services. Furthermore, we construct graph models from the collected data, and analyse the connectivity of the services based on important graph-based measures. Then, random and targeted node removal attacks are simulated, and the corresponding vulnerability of cloud services is evaluated. Our results indicate that cloud service hosts are, on average, much better connected than average hosts. However, when interconnecting nodes are removed in a targeted manner, cloud connectivity is dramatically reduced.
Camera Ludica
(2019)
Purpose
Patent offices and other stakeholders in the patent domain need to classify patent applications according to a standardized classification scheme. The purpose of this paper is to examine the novelty of an application it can then be compared to previously granted patents in the same class. Automatic classification would be highly beneficial, because of the large volume of patents and the domain-specific knowledge needed to accomplish this costly manual task. However, a challenge for the automation is patent-specific language use, such as special vocabulary and phrases.
Design/methodology/approach
To account for this language use, the authors present domain-specific pre-trained word embeddings for the patent domain. The authors train the model on a very large data set of more than 5m patents and evaluate it at the task of patent classification. To this end, the authors propose a deep learning approach based on gated recurrent units for automatic patent classification built on the trained word embeddings.
Findings
Experiments on a standardized evaluation data set show that the approach increases average precision for patent classification by 17 percent compared to state-of-the-art approaches. In this paper, the authors further investigate the model’s strengths and weaknesses. An extensive error analysis reveals that the learned embeddings indeed mirror patent-specific language use. The imbalanced training data and underrepresented classes are the most difficult remaining challenge.
Originality/value
The proposed approach fulfills the need for domain-specific word embeddings for downstream tasks in the patent domain, such as patent classification or patent analysis.
The advance of high-throughput RNA-Sequencing techniques enables researchers to analyze the complete gene activity in particular cells. From the insights of such analyses, researchers can identify disease-specific expression profiles, thus understand complex diseases like cancer, and eventually develop effective measures for diagnosis and treatment. The high dimensionality of gene expression data poses challenges to its computational analysis, which is addressed with measures of gene selection. Traditional gene selection approaches base their findings on statistical analyses of the actual expression levels, which implies several drawbacks when it comes to accurately identifying the underlying biological processes. In turn, integrative approaches include curated information on biological processes from external knowledge bases during gene selection, which promises to lead to better interpretability and improved predictive performance. Our work compares the performance of traditional and integrative gene selection approaches. Moreover, we propose a straightforward approach to integrate external knowledge with traditional gene selection approaches. We introduce a framework enabling the automatic external knowledge integration, gene selection, and evaluation. Evaluation results prove our framework to be a useful tool for evaluation and show that integration of external knowledge improves overall analysis results.
Business process improvement is an endless challenge for many organizations. As long as there is a process, it must he improved. Nowadays, improvement initiatives are driven by professionals. This is no longer practical because people cannot perceive the enormous data of current business environments. Here, we introduce ubiquitous decision-aware business processes. They pervade the physical space, analyze the ever-changing environments, and make decisions accordingly. We explain how they can be built and used for improvement. Our approach can be a valuable improvement option to alleviate the workload of participants by helping focus on the crucial rather than the menial tasks.
Enterprises reach out for collaborations with other organizations in order to offer complex products and services to the market. Such collaboration and coordination between different organizations, for a good share, is facilitated by information technology. The BPMN process choreography is a modeling language for specifying the exchange of information and services between different organizations at the business level. Recently, there is a surging use of the REST architectural style for the provisioning of services on the web, but few systematic engineering approach to design their collaboration. In this paper, we address this gap in a comprehensive way by defining a semi-automatic method for the derivation of RESTful choreographies from process choreographies. The method is based on natural language analysis techniques to derive interactions from the textual information in process choreographies. The proposed method is evaluated in terms of effectiveness resulting in the intervention of a web engineer in only about 10% of all generated RESTful interactions.
A catalog of genetic loci associated with kidney function from analyses of a million individuals
(2019)
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.