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Riback et al. (Reports, 13 October 2017, p. 238) used small-angle x-ray scattering (SAXS) experiments to infer a degree of compaction for unfolded proteins in water versus chemical denaturant that is highly consistent with the results from Forster resonance energy transfer (FRET) experiments. There is thus no "contradiction" between the two methods, nor evidence to support their claim that commonly used FRET fluorophores cause protein compaction.
In this Comment, we review the results of pattern formation in a reaction-diffusion-advection system following the kinetics of the Gray-Scott model. A recent paper by Das [Phys. Rev. E 92, 052914 (2015)] shows that spatiotemporal chaos of the intermittency type can disappear as the advective flow is increased. This study, however, refers to a single point in the space of kinetic parameters of the original Gray-Scott model. Here we show that the wealth of patterns increases substantially as some of these parameters are changed. In addition to spatiotemporal intermittency, defect-mediated turbulence can also be found. In all cases, however, the chaotic behavior is seen to disappear as the advective flow is increased, following a scenario similar to what was reported in our earlier work [I. Berenstein and C. Beta, Phys. Rev. E 86, 056205 (2012)] as well as by Das. We also point out that a similar phenomenon can be found in other reaction-diffusion-advection models, such as the Oregonator model for the Belousov-Zhabotinsky reaction under flow conditions.
À partir des travaux des ethnologues qui ont décrit le fonctionnement des sociétés paysannes de l’Ancien Régime, nous montrons dans cet article comment le récit de l’enfance bretonne de Chateaubriand dans les ‚Mémoires d’outre-tombe‘ obéit à une logique initiatique qui donne à l’animal un rôle de premier plan. Transformée en véritable „aventure“, la capture des oiseaux devient pour l’enfant l’occasion de forger son caractère et de découvrir le sens de l’honneur, tandis que la contemplation de leur envol éveille en lui le goût des voyages qu’il n’a pas encore la possibilité d’assouvir. À Combourg, chouettes et chat noir peuplent les nuits de l’enfant et l’obligent à dompter ses peurs. Quant au cheval, que Chateaubriand a mal appris à maîtriser, il devient sous sa plume l’emblème d’une époque révolue dominée par les privilèges de l’aristocratie et le signe de l’inadaptation des derniers rois de France. Il restera à l’écrivain à s’emparer de cette familiarité avec le monde animal pour nourrir son imaginaire et sa sensibilité de plus en plus grande au sort que lui réserve la société.
Modern production infrastructures of globally operating companies usually consist of multiple distributed production sites. While the organization of individual sites consisting of Industry 4.0 components itself is demanding, new questions regarding the organization and allocation of resources emerge considering the total production network. In an attempt to face the challenge of efficient distribution and processing both within and across sites, we aim to provide a hybrid simulation approach as a first step towards optimization. Using hybrid simulation allows us to include real and simulated concepts and thereby benchmark different approaches with reasonable effort. A simulation concept is conceptualized and demonstrated qualitatively using a global multi-site example.
In the comment on "Varves of the Dead Sea sedimentary record." Quaternary Science Reviews 215 (Ben Dor et al., 2019): 173-184. by R. Bookman, two recently published papers are suggested to prove that the interpretation of the laminated sedimentary sequence of the Dead Sea, deposited mostly during MIS2 and Holocene pluvials, as annual deposits (i.e., varves) is wrong. In the following response, we delineate several lines of evidence which coalesce to demonstrate that based on the vast majority of evidence, including some of the evidence provided in the comment itself, the interpretation of these sediments as varves is the more likely scientific conclusion. We further discuss the evidence brought up in the comment and its irrelevance and lack of robustness for addressing the question under discussion.