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It has recently been demonstrated that the presentation of a rare target in a visual oddball paradigm induces a prolonged inhibition of microsaccades. In the field of electrophysiology, the amplitude of the P300 component in event-related potentials (ERP) has been shown to be sensitive to the stimulus category (target vs. non target) of the eliciting stimulus, its overall probability, and the preceding stimulus sequence. In the present study we further specify the functional underpinnings of the prolonged microsaccadic inhibition in the visual oddball task, showing that the stimulus category, the frequency of a stimulus and the preceding stimulus sequence influence microsaccade rate. Furthermore, by co-recording ERPs and eye-movements, we were able to demonstrate that, despite being largely sensitive to the same experimental manipulation, the amplitude of P300 and the microsaccadic inhibition predict each other very weakly, and thus constitute two independent measures of the brain’s response to rare targets in the visual oddball paradigm.
Fontanes Medien
(2023)
Theodor Fontane war, im durchaus modernen Sinne, ein Medienarbeiter: Als Presse-Agent in London lernte er die innovativste Presselandschaft seiner Zeit kennen; als Redakteur in Berlin leistete er journalistische Kärrnerarbeit; er schrieb Kritiken über das Theater, die bildende Kunst und die Literatur – und auch seine Romane wie seine Reisebücher sind stets Medienprodukte, als Serien in in Zeitungen und Zeitschriften platziert, bevor sie auf dem Buchmarkt erschienen.
Der vorliegende Band dokumentiert die Ergebnisse eines internationalen Kongresses, veranstaltet 2019 vom Theodor-Fontane-Archiv in Potsdam. Die ebenso rasante wie umfassende Medialisierung und Vernetzung der Gesellschaft im Laufe des 19. Jahrhunderts wird dabei als produktive Voraussetzung der schriftstellerischen Tätigkeit Fontanes begriffen. Eingebettet in ein weit verzweigtes Netz der Korrespondenz und der postalischen Textzirkulation, vertraut mit den Routinen und Publika der periodischen Massenpresse, für die er sein Leben lang schrieb, und auf vielfältige Weise geprägt von der visuellen Kultur seiner Zeit wird Theodor Fontane als gleichermaßen journalistisch versierter wie ästhetisch sensibler Grenzgänger erkennbar.
Hegemonialmächte im Vorderen und Mittleren Orient : die Dritte Partei in internationalen Konflikten
(1997)
During the last five decades hegemons played an important role in de-escalating international conflicts in the subregion defined as the core of Oriens Islamicus. Statistical analysis of large datasets shows that half of all conflicts remained without any interference from the hegemonial powers at all - both on global scale and in the subregion. In all other cases however, hegemons (especially super-powers in the role of patrons) tended more often to act as (power-) mediators when their client-state was engaged in conflict with a client of the opposing superpower in Oriens Islamicus than they did on global scale. They did this in their own interest in order to avoid direct involvement, i.e. possible danger of a nuclear escalation. In contrast to conventional mediation theory they were more effective in conflict de-escalation than other mediators, especially in conflicts between Israel and its Arab neighbours. The end of bipolarity in the international system also brought this mechanism of de-escalation to an end. It leaves the hegemon(s) as a potentially powerful third party on the one hand, but on the other their inclination to become involved in regional conflict remains rather diminished as long as the basic national interests in the area are not at stake.
The dramatic changes in international relations characterized by the terms "Complex Interdependence" and "Segmentary Globalization" call for new explanation. The author considers the post-modern approaches, a critical analysis of which he presents, to be one possibility to do that. In studies of international policy, these post-modern influences are gaining ground in disputes with realistic and neo-realistic approaches, and they can also clearly be felt in Latin America. Tomassini, based on the historic experiences of Latin America, forcefully calls for an active and constructive incorporation of the region into international developments. For that, Latin-American societies have to establish modern, and open political as well as economic systems which are able to meet those challenges.
Gomułka’s harsh criticism of the Stalinist past and the introduction of liberal elements into the public life of Poland was not welcomed by the East German leadership. Ulbricht demanded full support for the sovereignty of the GDR and tried to prevent any independent Polish moves to come to terms with the Federal Republic. The Polish leadership strived towards a closer economic integration with the GDR and Czechoslovakia to foster industrial development in Poland and to bind the East German state more closely into the "socialist camp". These ideas were flatly rejected by the GDR. The level of economic interdependence between the two German states and the advantages of the GDR resulting from the "intra-German" status of trade and transfer of technologies provoked Gomułka’s distrust. Relations worsened even more when, towards the end of his time in power, Ulbricht moved towards a rapprochement with the FRG and showed some readiness to question the Görlitz treaty on the German-Polish border line.
Die Zukunft Osteuropas entscheidet sich im Spannungsfeld zwischen Russland und der EU. Die dortigen Staaten lösen sich aus der einseitigen Abhängigkeit eines erstarkten und seine Interessen im postsowjetischen Raum verteidigenden Russland. Ob die EU diese Chance in Osteuropa nutzen kann, hängt davon ab, ob sich die Mitgliedstaaten bereitfinden, ihre wirtschaftlichen und geopolitischen Interessen in der Region gemeinsam zu verfolgen.
Neue Akzente statt Neubeginn
(2006)
We investigate whether political ideology has an observable effect on decarbonization ambition, renewable power aims, and preferences for power system balancing technologies in four European countries. Based on the Energy Logics framework, we identify ideologically different transition strategies (state-centered, market-centered, grassroots-centered) contained in government policies and opposition party programs valid in 2019. We compare these policies and programs with citizen poll data. We find that ideology has a small effect: governments and political parties across the spectrum have similar, and relatively ambitious, decarbonization and renewables targets. This mirrors citizens' strong support for ambitious action regardless of their ideological self-description. However, whereas political positions on phasing out fossil fuel power are clear across the policy space, positions on phasing in new flexibility options to balance intermittent renewables are vague or non-existent. As parties and citizens agree on strong climate and renewable power aims, the policy ambition is likely to remain high, even if governments change.
Ghana’s local government system has been subject to various reform attempts which all involved some sort of decentralisation. This article tries to link decentralisation to changing national policy frames and the various governments’ need to maintain political control. Consequently, decentralisation becomes a dependent variable of the so called bureaucratic development state. After a brief discussion of the colonial and post-colonial local government system in Ghana, emphasis is placed on the crisis of the post colonial state and the emergence of a new local government system in 1988 - which was successfully transformed into the administrative system of Ghana’s 4th republic after 1992. Local participation has been substantially improved an sustained by the introduction of the District Assemblies Common Fund in 1993 which transfers 5% of the national tax income to the districts.
With the new government, coming to power in 1998, a new emphasis on development cooperation as part of a global strategy for structural change was launched. Since then the federal minister for development cooperation – Heidemarie Wieczorek- Zeul – presented some interesting strategic papers under the label "aid as a global policy to overcome structural blockades to social progress and development". Special emphasis was put on the Program of Action for Poverty Reduction and on the strategy paper of a new Africa policy, but neither are concrete results yet in sight nor is an answer to the burning question of what to do with half of all African countries not having a long-term perspective for development at all (the "failing states" etc.). The article shows the great discrepancy between the impressive political rhetoric and the meager budget to cope with the many challenges of the poor developing countries in Africa. The new concept of the enlarged security intends to stabilize the structural conditions for social and economic development. In order to realize this aim, the article proposes a link between public expenditures on military measures for security and such on civil measures for structural security. Finally the article asks how development cooperation can influence the political attitudes of state and society in Africa in the direction of good governance and structural reforms.
Intuitively, strongly constraining contexts should lead to stronger probabilistic representations of sentences in memory. Encountering unexpected words could therefore be expected to trigger costlier shifts in these representations than expected words. However, psycholinguistic measures commonly used to study probabilistic processing, such as the N400 event-related potential (ERP) component, are sensitive to word predictability but not to contextual constraint. Some research suggests that constraint-related processing cost may be measurable via an ERP positivity following the N400, known as the anterior post-N400 positivity (PNP). The PNP is argued to reflect update of a sentence representation and to be distinct from the posterior P600, which reflects conflict detection and reanalysis. However, constraint-related PNP findings are inconsistent. We sought to conceptually replicate Federmeier et al. (2007) and Kuperberg et al. (2020), who observed that the PNP, but not the N400 or the P600, was affected by constraint at unexpected but plausible words. Using a pre-registered design and statistical approach maximising power, we demonstrated a dissociated effect of predictability and constraint: strong evidence for predictability but not constraint in the N400 window, and strong evidence for constraint but not predictability in the later window. However, the constraint effect was consistent with a P600 and not a PNP, suggesting increased conflict between a strong representation and unexpected input rather than greater update of the representation. We conclude that either a simple strong/weak constraint design is not always sufficient to elicit the PNP, or that previous PNP constraint findings could be an artifact of smaller sample size.
The requirements of modern e-learning techniques change. Aspects such as community interaction, flexibility, pervasive learning and increasing mobility in communication habits become more important. To meet these challenges e-learning platforms must provide support on mobile learning. Most approaches try to adopt centralised and static e-learning mechanisms to mobile devices. However, often technically it is not possible for all kinds of devices to be connected to a central server. Therefore we introduce an application of a mobile e-learning network which operates totally decentralised with the help of an underlying ad hoc network architecture. Furthermore the concept of ad hoc messaging network (AMNET) is used as basis system architecture for our approach to implement a platform for pervasive mobile e-learning.
Background
Animal personality has emerged as a key concept in behavioral ecology. While many studies have demonstrated the influence of personality traits on behavioral patterns, its quantification, especially in wild animal populations, remains a challenge. Only a few studies have established a link between personality and recurring movements within home ranges, although these small-scale movements are of key importance for identifying ecological interactions and forming individual niches. In this regard, differences in space use among individuals might reflect different exploration styles between behavioral types along the shy-bold continuum.
Methods
We assessed among-individual differences in behavior in the European hare (Lepus europaeus), a characteristic mammalian herbivore in agricultural landscapes using a standardized box emergence test for captive and wild hares. We determined an individuals’ degree of boldness by measuring the latencies of behavioral responses in repeated emergence tests in captivity. During capture events of wild hares, we conducted a single emergence test and recorded behavioral responses proven to be stable over time in captive hares. Applying repeated novel environment tests in a near-natural enclosure, we further quantified aspects of exploration and activity in captive hares. Finally, we investigated whether and how this among-individual behavioral variation is related to general activity and space use in a wild hare population. Wild and captive hares were treated similarly and GPS-collared with internal accelerometers prior to release to the wild or the outdoor enclosure, respectively. General activity was quantified as overall dynamic body acceleration (ODBA) obtained from accelerometers. Finally, we tested whether boldness explained variation in (i) ODBA in both settings and (ii) variation in home ranges and core areas across different time scales of GPS-collared hares in a wild population.
Results
We found three behavioral responses to be consistent over time in captive hares. ODBA was positively related to boldness (i.e., short latencies to make first contact with the new environment) in both captive and wild hares. Space use in wild hares also varied with boldness, with shy individuals having smaller core areas and larger home ranges than bold conspecifics (yet in some of the parameter space, this association was just marginally significant).
Conclusions
Against our prediction, shy individuals occupied relatively large home ranges but with small core areas. We suggest that this space use pattern is due to them avoiding risky, and energy-demanding competition for valuable resources. Carefully validated, activity measurements (ODBA) from accelerometers provide a valuable tool to quantify aspects of animal personality along the shy-bold continuum remotely. Without directly observing—and possibly disturbing—focal individuals, this approach allows measuring variability in animal personality, especially in species that are difficult to assess with experiments. Considering that accelerometers are often already built into GPS units, we recommend activating them at least during the initial days of tracking to estimate individual variation in general activity and, if possible, match them with a simple novelty experiment. Furthermore, information on individual behavioral types will help to facilitate mechanistic understanding of processes that drive spatial and ecological dynamics in heterogeneous landscapes.
Prediction of hybrid biomass in Arabidopsis thaliana by selected parental SNP and metabolic markers
(2009)
A recombinant inbred line (RIL) population, derived from two Arabidopsis thaliana accessions, and the corresponding testcrosses with these two original accessions were used for the development and validation of machine learning models to predict the biomass of hybrids. Genetic and metabolic information of the RILs served as predictors. Feature selection reduced the number of variables (genetic and metabolic markers) in the models by more than 80% without impairing the predictive power. Thus, potential biomarkers have been revealed. Metabolites were shown to bear information on inherited macroscopic phenotypes. This proof of concept could be interesting for breeders. The example population exhibits substantial mid-parent biomass heterosis. The results of feature selection could therefore be used to shed light on the origin of heterosis. In this respect, mainly dominance effects were detected.
"Copernican" is the term the author is calling the turn in present Islamism. After a mostly failed fundamentalist reaction to a high-speed westernisation, there are current debates among Islamists to find an own identity - based on Islam and connected with Western values. Aim of these efforts is to link Islam with the contemporary realities in the Arabian world.
The author shows the strong relation between political developments, frontiers and their graphical representation on maps. Human rights, economic globalisation and the European integration process do change national policy and erode classical border lines. Still today, maps with lines and colours as their main graphic elements represent the world of the 19th century with separate national states in atlases, schoolbooks and electronic media. The main argument of the article insists on stressing the political character of maps and showing the contradiction between the cartographic picture of the world and the recent international transformations. The author concludes with the question of whether maps can reproduce these new developments at all.
Indien und die G8
(2007)
Seit 2005 ist Indien als eines der fünf Outreach-Länder in die Diskussionen der G8 eingebunden. Dies geschah wegen seiner Rolle als eine der Kraftquellen der Weltwirtschaft sowie als viertgrößter globaler Markt. Indien betrachtet ein offenes Welthandelregime und einen größeren Kapitalfluss in die Entwicklungsländer als notwendig, um diesen zu helfen, deren Exporte zu steigern, neue Jobs zu schaffen und den Wohlstand ihrer Produzenten zu erhöhen.
This article is a reply to a statement by Elke Schwinger in WeltTrends 31. The author tries to strike the balance between "coming to terms with the past" and the role of criminal law in this process in Germany. The principle of prohibition of retroactive laws, fixed in the 1990 German Unification Treaty and in the Constitution, had been broken in the trials against the "Mauerschützen" (border guards) in German criminal courts since 1990. There is an artificially constructed past which does not correspond to the reality of the border regime before 1989. The author underlines that today the criminal law is misused for political aims within the German unification process.
Die Individualbeschwerde nach dem Fakultativprotokoll zum Zivilpakt : ein Handbuch für die Praxis
(2004)
Das vorliegende Handbuch bietet vertiefende Informationen zur Individualbeschwerde nach dem Fakultativprotokoll zum Internationalen Pakt über bürgerliche und politische Rechte. Das Handbuch richtet sich in erster Linie an Praktiker/innen, die in ihrer Arbeit mit Menschenrechtsverletzungen konfrontiert sind, insbesondere Rechtsanwälte und Rechtsanwältinnen sowie Menschenrechtsorganisationen. In umfassender, aber komprimierter Form gibt es zuverlässige Hilfestellung bei der Einlegung einer Beschwerde. Darüber hinaus ist das Handbuch auch für Mitarbeitende in Ministerien, Universitäten und sonstigen Einrichtungen geeignet, die sich mit der Materie vertraut machen wollen. (Autorenreferat)
In the spring issue of WeltTrends, Gunther Hellmann (Johann-Wolfgang-Goethe- Universität Frankfurt a. M.) sparked a debate on Germany’s foreign policy. He argued that Germany’s international behaviour is dominated by a Realpolitik policy generally referred to as "normalization". For Hellmann this transformation indicates "the deepest crisis of German foreign policy" ever. Hellmann proposes a rehabilitation of the tradition of the Bonner Republik and an active Idealpolitik. This summer issue of WeltTrends features eleven articles written in response to Hellmann by International Relations scholars. The debate focuses on analytical as well as normative aspects of current German foreign policy. The authors discuss the context of the European Common Foreign and Security Policy, the international system and the United Nations, historical aspects of German foreign policy and the German foreign policy discourse. While some contributors share Hellmann's idealist position, most challenge his plea from a more realist perspective. In the upcoming fall issue, this debate will be continued with contributions by German foreign policy makers. A final reply by Hellmann will complete the debate in the winter issue of WeltTrends. Contributions by: Franz Ansprenger, Stephan Böckenförde, Wilfried von Bredow, Sabine Busse, Edwina S. Campbell, Hartmut Elsenhans, Hans J. Gießmann, Werner Link, Carlo Masala, Hanns W. Maull, and Siegfried Schwarz.
Indonesia’s arduous path to democracy is threatened by several domestic conflicts. Although the civil war in Aceh – a region in the north of Sumatra – has claimed thousands of victims, the incidents have not yet been adequately dealt with – neither in the public domain nor within the scientific community. In May 2003, the Indonesian president, Megawati Sukarnoputri, imposed material law on the Aceh region in order to crack down on the separatist movement Gerakan Aceh Merdeka (GAM). This step does not seem to be in line with serious concepts of democracy and is threatening the consolidation of the transformation process. The author seeks to shed light on the roots of the conflict, the motivation of leading politicians in Jakarta to deploy military means instead of continuing negotiations, and its consequences for the Indonesian process of democratisation.
Two years after the end of the "hot war" in Kosovo, the situation on the Balkans remains extremely tense. The West embraced the illusion to provide the Kosovo-Albanians with conditions for a substantial autonomy under the umbrella of an international protectorate. The Kosovo-Albanians considered the substantial autonomy as a milestone on their way to independence, while a new Yugoslav-Serbian administration counted on regaining sovereign rights in Kosovo. The escalation of the crisis provided a fresh impetus for new expectations regarding the national question. The claim to separate Kosovo from Yugoslavia had been strengthened. The Albanian role in this process remained ambiguous. Albania has to be considered as an actor and an object, and it perceives its national geopolitical and security interests as affected by the process in Kosovo. Tirana's political orientation is strongly moving towards the Euro-Atlantic community, yet hegemonic interests vis-à-vis Kosovo might play an important role besides Tirana's own limited political influence over the developments in Kosovo.
Geheimdienste in Demokratien
(2006)
Geheimdienste sind für den modernen Staat zur Gewährleistung seiner inneren und äußeren Sicherheit wesentlich und stehen ständig vor neuen Herausforderungen. Die Dienste der Bundesrepublik sind aus der Frontstaatlage im Kalten Krieg gewachsen, und ihr Wert als geheimes Regierungsinstrument ist durch eine Vielzahl systemischer Probleme erheblich eingeschränkt. Zudem gibt es weder eine klare Standortbestimmung der Dienste im politischen System, noch eine moralische Grenzziehung ihrer Aktivitäten.
The security policy of Pakistan is aimed at a reduction of nuclear threats in the South Asian region. It is only natural, that a state, whose national security is endangered by a mighty neighbor, will have to strengthen its defense capacities. Unfortunately, the effective collective measures to prevent and to remove threats to peace and international security as laid down in the Charter of the United Nations prove to be an unreliable promise. Ever since India carried out its first nuclear tests in 1974, Pakistan has been forced into a race to catch up with the capabilities if its neighbor. Nevertheless, Pakistan chose a minimalist approach and refrained from converting its nuclear capabilities into weapon systems. Pakistan is against an arms race in the South Asian region, and opposes the concept of first use of nuclear weapons. To ensure lasting peace, a common vision on disarmament is necessary.
The comprehensive transformation after the breakdown of communist rule was also reflected in a profound change in national policies. The dominating approach in the days of the old regime were grounded in the concept of a single nation state. The years since 1989 witnessed a rise of new democratic attitudes towards national and ethnic minorities. National minorities make up 3 to 4% of the population. Their total number is estimated to be approximately 1.0 to 1.3 Million people. Contemporary national policy rejects the principle of assimilation (polonization) of national and ethnic minorities while supporting their integration.
Wider den „euro-atlantischen Internationalismus“ : Berliner Republik und Entgrenzung der Bundeswehr
(2007)
Inhalt: Frieden mit aller Gewalt schaffen? Tatbestand: Staatsterrorismus Das Weißbuch 2006 Bundesverfassungsgericht versus Bundesverwaltungsgericht Weltweites Interventionsrecht Lizenz zum Völkerrechtsbruch „Re-Transformation“ der Bundeswehr Prinzipien für einen sicherheitspolitischen Grundkonsens Breite öffentliche Debatte notwendig
The economic reforms in the German Democratic Republic during the 60s, known as "New Economic System" (NES) or "Economic System of Socialism" (ESS) have been characterised by historians as truly technocratic. What is often not known is the fact, that during the first debate on economic reform in Eastern Germany in 1954-1958 the idea of democratic reform was prominent thanks to the role and writing of the outstanding GAR economist Fritz Behrens, who favoured a diminished role of the state in the economy and the self-rule of the workers in the factories. Behrens and his followers were denounced by party leader Walter Ulbricht as "revisionist". Together with his economic advisor, Wolfgang Berger, originally a scholar of Behrens’, he started the NES and ESS in the 60s. Behrens remained barred from the management of the reform, in which Berger plaid a prominent role. When Behrens began again to publish his demands for a democratic reform in 1967, thus intervening in the progress of the reform, he was forced to leave his academic job into retirement. In 1971, Erich Honekker succeeded Ulbricht. The economic reform was stopped. And Berger lost his job, too.
In this paper, we consider families of time Markov fields (or reciprocal classes) which have the same bridges as a Brownian diffusion. We characterize each class as the set of solutions of an integration by parts formula on the space of continuous paths C[0; 1]; R-d) Our techniques provide a characterization of gradient diffusions by a duality formula and, in case of reversibility, a generalization of a result of Kolmogorov.
We develop a cluster expansion in space-time for an infinite-dimensional system of interacting diffusions where the drift term of each diffusion depends on the whole past of the trajectory; these interacting diffusions arise when considering the Langevin dynamics of a ferromagnetic system submitted to a disordered external magnetic field.
The authors analyse different Gibbsian properties of interactive Brownian diffusions X indexed by the d-dimensional lattice. In the first part of the paper, these processes are characterized as Gibbs states on path spaces. In the second part of the paper, they study the Gibbsian character on R^{Z^d} of the law at time t of the infinite-dimensional diffusion X(t), when the initial law is Gibbsian. AMS Classifications: 60G15 , 60G60 , 60H10 , 60J60
We prove in this paper an existence result for infinite-dimensional stationary interactive Brownian diffusions. The interaction is supposed to be small in the norm ||.||∞ but otherwise is very general, being possibly non-regular and non-Markovian. Our method consists in using the characterization of such diffusions as space-time Gibbs fields so that we construct them by space-time cluster expansions in the small coupling parameter.
Do the transatlantic relations have a future after the Iraq crisis and what will they look like? This question will be discussed in this and the next issue of WeltTrends. For this debate, Thomas Risse, Chair of International Relation at the Freie Universität Berlin, provides the initial input. Risse focuses on controversial issues inside of Europe, the outcome of which will be decisive for the future of the transatlantic relationship. Will the European consensus once constituted by the commitment to international law and multilateralism persist? What is the European position regarding democracy and human rights in the Middle East? Will Europe develop a strategy to cope with the new kind of threats posed by weapons of mass destruction in the hands of dictators or terrorists? Risse´s article has provoked a debate inside the German academic community, whose contributions will be published in the next issue of WeltTrends.
In this issue, we continue and complete the debate on the future of the transatlantic relationship and of world order after the Iraq war. The debate was initiated by an article by Thomas Risse (Freie Universität Berlin) in WeltTrends 39, which has provoked a remarkable reaction within the German academic community, as documented in WeltTrends 40. This issue features additional comments and the rebuttal by Thomas Risse. Most authors believe that the transatlantic partnership is in a serious crisis, but claim that it remains without an alternative for both sides of the Atlantic.
Bei N = 101 Arbeitnehmern verschiedener Berufe wurden mit der Experience Sampling Method (ESM) eine Woche lang Daten zum Flow-Erleben, zu Glück/Zufriedenheit und zur Zielausrichtung laufender Aktivitäten erhoben (N = 4603 Messungen). Die Daten wurden mit GLMM-Analysen ausgewertet. Auch bei der jetzt vollständigen Erfassung aller Flow-Komponenten mit der FKS bestätigte sich das „Paradoxon der Arbeit“, wonach während der Arbeit höhere Flow-Werte, aber niedrigere Werte für Glück/Zufriedenheit auftreten als jeweils in der Freizeit. Während der Arbeit waren Aktivitäten häufiger auf die Erreichung von Zielen ausgerichtet als während der Freizeit. Die Zielausrichtung wirkte auf Flow vs. Glück/Zufriedenheit signifikant verschieden. Während der Arbeit hat die Zielausrichtung auf Flow einen stark positiven Effekt, auf Glück/Zufriedenheit jedoch nicht. Im Freizeitbereich war der Effekt von Zielausrichtung auf Glück/Zufriedenheit sogar negativ. Das „Paradoxon der Arbeit“ lässt sich partiell als Effekt der Zielausrichtung verstehen.
Irans zunehmender Einfluss als Regionalmacht wird wegen seines Atomprogramms und seiner antiwestlichen Politik als Störfaktor bewertet. Die offensive Rhetorik Teherans zielt primär darauf ab, möglichen Gefahren entgegenzutreten. Westliche Politik sollte das allseitig bestehende Interesse an regionaler Stabilität nutzen, um seine ausschließlich auf Eindämmung bedachte Politik zu überwinden.
Investigations with frequency domain photon density waves allow elucidation of absorption and scattering properties of turbid media. The temporal and spatial propagation of intensity modulated light with frequencies up to more than 1 GHz can be described by the P1 approximation to the Boltzmann transport equation. In this study, we establish requirements for the appropriate choice of turbid model media and characterize mixtures of isosulfan blue as absorber and polystyrene beads as scatterer. For these model media, the independent determination of absorption and reduced scattering coefficients over large absorber and scatterer concentration ranges is demonstrated with a frequency domain photon density wave spectrometer employing intensity and phase measurements at various modulation frequencies.
Dermal Delivery of the High-Molecular-Weight Drug Tacrolimus by Means of Polyglycerol-Based Nanogels
(2019)
Polyglycerol-based thermoresponsive nanogels (tNGs) have been shown to have excellent skin hydration properties and to be valuable delivery systems for sustained release of drugs into skin. In this study, we compared the skin penetration of tacrolimus formulated in tNGs with a commercial 0.1% tacrolimus ointment. The penetration of the drug was investigated in ex vivo abdominal and breast skin, while different methods for skin barrier disruption were investigated to improve skin permeability or simulate inflammatory conditions with compromised skin barrier. The amount of penetrated tacrolimus was measured in skin extracts by liquid chromatography tandem-mass spectrometry (LC-MS/MS), whereas the inflammatory markers IL-6 and IL-8 were detected by enzyme-linked immunosorbent assay (ELISA). Higher amounts of tacrolimus penetrated in breast as compared to abdominal skin or in barrier-disrupted as compared to intact skin, confirming that the stratum corneum is the main barrier for tacrolimus skin penetration. The anti-proliferative effect of the penetrated drug was measured in skin tissue/Jurkat cells co-cultures. Interestingly, tNGs exhibited similar anti-proliferative effects as the 0.1% tacrolimus ointment. We conclude that polyglycerol-based nanogels represent an interesting alternative to paraffin-based formulations for the treatment of inflammatory skin conditions.
The complement fragments C3a and C5a were purified from zymosan-activated human serum by column chromatographic procedures after the bulk of the proteins had been removed by acidic polyethylene glycol precipitation. In the isolated in situ perfused rat liver C3a increased glucose and lactate output and reduced flow. Its effects were enhanced in the presence of the carboxypeptidase inhibitor DL-mercaptomethyl-3-guanidinoethylthio-propanoic acid (MERGETPA) and abolished by preincubation of the anaphylatoxin with carboxypeptidase B or with Fab fragments of an anti-C3a monoclonal antibody. The C3a effects were partially inhibited by the thromboxane antagonist BM13505. C5a had no effect. It is concluded that locally but not systemically produced C3a may play an important role in the regulation of local metabolism and hemodynamics during inflammatory processes in the liver.
In the isolated rat liver perfused in situ stimulation of the nerve bundles around the portal vein and the hepatic artery caused an increase of urate formation that was inhibited by the α1-blocker prazosine and the xanthine oxidase inhibitor allopurinol. Moreover, nerve stimulation increased glucose and lactate output and decreased perfusion flow. Infusion of noradrenaline had similar effects. Compared to nerve stimulation infusion of glucagon led to a less pronounced increase of urate formation and a twice as large increase in glucose output but a decrease in lactate release without affecting the flow rate. Insulin had no effect on any of the parameters studied.
Increase in prostanoid formation in rat liver macrophages (Kupffer cells) by human anaphylatoxin C3a
(1993)
Human anaphylatoxin C3a increases glycogenolysis in perfused rat liver. This action is inhibited by prostanoid synthesis inhibitors and prostanoid antagonists. Because prostanoids but not anaphylatoxin C3a can increase glycogenolysis in hepatocytes, it has been proposed that prostanoid formation in nonparenchymal cells represents an important step in the C3a-dependent increase in hepatic glycogenolysis. This study shows that (a) human anaphylatoxin C3a (0.1 to 10 mug/ml) dose-dependently increased prostaglandin D2, thromboxane B, and prostaglandin F2alpha formation in rat liver macrophages (Kupffer cells); (b) the C3a-mediated increase in prostanoid formation was maximal after 2 min and showed tachyphylaxis; and (c) the C3a-elicited prostanoid formation could be inhibited specifically by preincubation of C3a with carboxypeptidase B to remove the essential C-terminal arginine or by preincubation of C3a with Fab fragments of a neutralizing monoclonal antibody. These data support the hypothesis that the C3a-dependent activation of hepatic glycogenolysis is mediated by way of a C3a-induced prostanoid production in Kupffer cells.
Development of chronic pain after a low back pain episode is associated with increased pain sensitivity, altered pain processing mechanisms and the influence of psychosocial factors. Although there is some evidence that multimodal therapy (such as behavioral or motor control therapy) may be an important therapeutic strategy, its long-term effect on pain reduction and psychosocial load is still unclear. Prospective longitudinal designs providing information about the extent of such possible long-term effects are missing. This study aims to investigate the long-term effects of a homebased uni- and multidisciplinary motor control exercise program on low back pain intensity, disability and psychosocial variables. 14 months after completion of a multicenter study comparing uni- and multidisciplinary exercise interventions, a sample of one study center (n = 154) was assessed once more. Participants filled in questionnaires regarding their low back pain symptoms (characteristic pain intensity and related disability), stress and vital exhaustion (short version of the Maastricht Vital Exhaustion Questionnaire), anxiety and depression experiences (the Hospital and Anxiety Depression Scale), and pain-related cognitions (the Fear Avoidance Beliefs Questionnaire). Repeated measures mixed ANCOVAs were calculated to determine the long-term effects of the interventions on characteristic pain intensity and disability as well as on the psychosocial variables. Fifty four percent of the sub-sample responded to the questionnaires (n = 84). Longitudinal analyses revealed a significant long-term effect of the exercise intervention on pain disability. The multidisciplinary group missed statistical significance yet showed a medium sized long-term effect. The groups did not differ in their changes of the psychosocial variables of interest. There was evidence of long-term effects of the interventions on pain-related disability, but there was no effect on the other variables of interest. This may be partially explained by participant's low comorbidities at baseline. Results are important regarding costless homebased alternatives for back pain patients and prevention tasks. Furthermore, this study closes the gap of missing long-term effect analysis in this field.
Bezogen auf das Bruttoinlandsprodukt ist China eine wichtige regionale Wirtschaftsmacht, aber keine Supermacht. Doch das Wachstumspotential zehrt sich auf, auch weil die Investitionsdynamik der Unternehmen und der Bankensektor härteren Kreditrestriktionen unterworfen werden. Chinas bislang geschütztes Finanzsystem, das von der Globalisierung untergraben wird, ist die Achillesferse für das hohe Wachstum.
While at the time of Goethe, Turkey and other parts of the world seemed to be far away. Today’s Germany is confronted with the pressure of globalization. With regard to environmental issues or the threat of terrorism, international co-operation and combined efforts are strongly demanded. Unfortunately, the German higher education system is not prepared to face these challenges. The article calls for the education of an elite at German universities, which is fit to work in national as well in international institutions. The author presents the Master’s of International Relations coursework at the Technical University of Dresden.
Aus dem Inhalt: Die Juvenilhormone 1a-c werden im Blut von Insekten enzymatisch zu den biologisch inaktiven Sluren hydrolysiert. Bei der Hydrolyse von racemischem 1c im Blut der Wanderheuschrecke Locusta migratoria wird ein Umsatz von 40-60% erreicht. Das unumgesetzte Edukt enthällt einen Überschuß an natürlich konfiguriertem (10R)-1c (e.e. 47.2%). Wir konnten zeigen, daß das in der Hämolymphe vorhandene Hormon-Bindungsprotein bevorzugt mit (10R)- 1c assoziiert.
The synthesis of galactose clusters that are linked to a steroid moiety by a peptide-like spacer unit is described. The galactose cluster is obtained by Koenigs-Knorr glycosylation of TRIS-Gly-Fmoc (2b) under Helferich conditions. Peptide and ester bonds are formed after activation of carboxylic acids as diphenylthiophene dioxide (TDO) esters. 6a is synthesized in a convergent way by coupling of (Ac4Gal)3-TRIS-Gly (3e) with cholesteryl TDO succinate (5b). Coupling of (Ac4Gal)3-TRIS-Gly hydrogen succinate (3f) with Gly-O-Chol (5d) by means of EEDQ yields 6d. Reaction of (Ac4Gal)3-TRIS-Gly-SUCC-O-TDO (3g) with 25-hydroxycholesterol leads in a linear sequence to the oxysterol derivative 6f. Selective cleavage of the acetyl groups from galactose units yields the known compound 6b and the new derivatives 6e and 6g.