Extern
Refine
Year of publication
Document Type
- Article (43)
- Doctoral Thesis (19)
- Postprint (7)
- Conference Proceeding (3)
- Habilitation Thesis (1)
- Master's Thesis (1)
Keywords
- Chlamydomonas (3)
- photosynthesis (3)
- stunting (3)
- Animal personality (2)
- E. coli (2)
- Energy expenditure (2)
- European hare (2)
- Inter-individual differences (2)
- Movement ecology (2)
- ODBA (2)
- PUFA (2)
- Partial Little Square (2)
- Quantitative Trait Locus (2)
- Quantitative Trait Locus analysis (2)
- SEPE (2)
- Stoffwechsel (2)
- Summer Schools (2)
- Systembiologie (2)
- Systems Biology (2)
- acclimation (2)
- antibody (2)
- behaviour (2)
- body height (2)
- composition (2)
- ecophysiology (2)
- fatty acid (2)
- feature selection (2)
- food quality (2)
- malnutrition (2)
- mechanobiology (2)
- miRNA (2)
- photoresponse (2)
- physiology (2)
- recombinant inbred line (2)
- 5-methoxycarbonylmethyl-2-thiouridine (1)
- AC Elektrokinetik (1)
- AC Elektroosmosis (1)
- AC electrokinetics (1)
- AC electroosmosis (1)
- AFLP (1)
- APP (1)
- ARMS (1)
- Alzheimer's Disease (1)
- Aminosäuren (1)
- Antibiotic alternatives (1)
- Antibiotic resistance (1)
- Antibiotikaersatz (1)
- Antibiotikaresistenz (1)
- Antikörper (1)
- Arabidopsis thaliana (1)
- Assemblierungsfaktor (1)
- Beta-Zelle (1)
- Biofilm (1)
- Biogenese (1)
- Borna Disease Virus (1)
- Borna disease virus (1)
- Bryophytes (1)
- CDF (1)
- Chew Bahir (1)
- Chloroplast transformation (1)
- Chloroplastentransformation (1)
- Computational Biology (1)
- Damage assessment (1)
- Daphnia (1)
- Diabetes (1)
- Dielektrophorese (1)
- Disturbance impacts (1)
- Disturbance indicator (1)
- Diversität (1)
- Dreissena polymorpha (1)
- EAAT1 (1)
- ETV (1)
- Ecology (1)
- Ecotoxicology (1)
- Elephant disturbance (1)
- Erkenntnisgewinnung (1)
- European Alps (1)
- Evolution (1)
- Forschungsorientierung (1)
- Frucht (1)
- GC-MS (1)
- GPS (1)
- Gen-Koexpression (1)
- Gene co-expression (1)
- Glucolipotoxizität (1)
- Glutamat (1)
- Glutamate (1)
- Growth signaling (1)
- H2S biosynthesis (1)
- HMA (1)
- Hippo signaling (1)
- Hyperakkumulation (1)
- ICDP (1)
- ICP OES (1)
- IRF3 (1)
- Immunoassay (1)
- Importin (1)
- Influenza (1)
- Interactors (1)
- Interaktoren (1)
- Interferon <beta-> (1)
- Introgression (1)
- Just so stories (1)
- Kernlokalisierungssignal (1)
- LCSM (1)
- LOC (1)
- Lake Constance (1)
- Lehramtsstudium Biologie (1)
- Locally structured correlation (1)
- Locally structured standard deviation (1)
- MSAP (1)
- MTP (1)
- MTP1 (1)
- MTP2 (1)
- MTP3 (1)
- Mechanobiologie (1)
- Metabolic Modeling (1)
- Metabolism (1)
- Metabolit (1)
- Metabolome (1)
- Methankreislauf (1)
- Microtus arvalis (1)
- Middle East (1)
- Moco biosynthesis (1)
- Modeling (1)
- Modellierung (1)
- Monte Carlo method (1)
- Morbus Alzheimer (1)
- NZO (1)
- Nanoelektroden (1)
- Nitrat (1)
- Nitrogen deposition (1)
- Omicron (1)
- P-Typ ATPase (1)
- POC (1)
- Permafrostökosysteme (1)
- Phage lysins (1)
- Phagenlysine (1)
- Phosphoproteomik (1)
- Photosynthese (1)
- Photosystem I (1)
- Pipistrellus nathusii (1)
- Polyneuropathie (1)
- Populationsdynamik (1)
- Professionswissen (1)
- Proteomics (1)
- Repetition (1)
- Rotifera (1)
- SARS-CoV-2 (1)
- SEPE Factors (1)
- SEPS factors (1)
- Social-Economic-Political-Emotional (SEPE) factors (1)
- Species richness (1)
- Specific wood density (1)
- Spleißvariante (1)
- Splice Variant (1)
- Split Ubiquitin (1)
- Spurengasflüsse (1)
- St. Nicolas House Analysis (1)
- Standard deviation (1)
- Statistical Exercise (1)
- Stickstoff (1)
- Succession (1)
- TBK1 (1)
- TMAO reductase (1)
- TRPV1 (1)
- Tabak (1)
- Target of Rapamycin kinase (1)
- Thylakoidmembran (1)
- Tomate (1)
- Tomato (1)
- Tree allometry (1)
- Understorey (1)
- Variance (1)
- Vascular plants (1)
- Virus (1)
- Wachstumssignale (1)
- Wood specific gravity (1)
- Woody aboveground biomass (1)
- Yap1/Wwtr1 (Taz) (1)
- Zink (1)
- Züchtung (1)
- accelerometer (1)
- acid mine drainage (1)
- acoustic communication (1)
- adaptive management (1)
- agricultural landscape (1)
- alga (1)
- amino acids (1)
- animal migration (1)
- animal personality (1)
- assembly factor (1)
- augmented reality (1)
- automated radio telemetry (1)
- bats (1)
- behavioral type (1)
- beta-cell (1)
- biodiversity conservation (1)
- biofilm (1)
- biogenesis (1)
- biological age (1)
- biology (1)
- birth weight (1)
- bis-MGD (1)
- body mass index (1)
- body proportions (1)
- breastfeeding (1)
- breeding (1)
- buffer zones (1)
- camelid antibody (1)
- camelid heavy-chain-only antibodies (1)
- carbon cycling (1)
- cardiac development (1)
- catch-up-growth (1)
- cellular bioenergetics (1)
- cellulose polymeric organic matter (1)
- changepoint analysis (1)
- changepoint detection (1)
- chaperone (1)
- child growth (1)
- chronic pain (1)
- chronic undernutrition (1)
- chronischer Schmerz (1)
- climate change (1)
- community model (1)
- computergestützte Biologie (1)
- consumer (1)
- cost optimisation (1)
- crops (1)
- cross-species capture (1)
- cytosine methylation (1)
- cytosolic tRNA thiolation (1)
- daily home-made measurements (1)
- dental eruption (1)
- diabetes (1)
- dielectrophoresis (1)
- diversity (1)
- eavesdropping (1)
- echolocation (1)
- economy (1)
- ecosystem restoration (1)
- education (1)
- emotional stress (1)
- endocardium (1)
- endophytes (1)
- energy expenditure (1)
- energy metabolism (1)
- environmental pollution (1)
- extracellular enzymes (1)
- extremophiles (1)
- fear (1)
- fence ecology (1)
- fitness (1)
- food access (1)
- food web (1)
- formate assimilation (1)
- frame index (1)
- freshwater (1)
- fruit (1)
- functional traits (1)
- fungi (1)
- genome scan (1)
- global change (1)
- glucolipotoxicity (1)
- grazer (1)
- growth references (1)
- growth standards (1)
- growth tempo (1)
- guideline (1)
- handgrip strength (1)
- heavy-chain-only antibody (1)
- height in history (1)
- heliozoa (1)
- herbivore (1)
- historical growth (1)
- home range (1)
- hybridization capture (1)
- hyperaccumulation (1)
- iPhone (1)
- immunoassay (1)
- importin (1)
- influenza (1)
- inquiry (1)
- intra-organ-communication (1)
- intraguild predation (1)
- kelp (1)
- lab-on-chip (1)
- lebende Materialien (1)
- life history (1)
- linear enamel hypoplasia (1)
- living materials (1)
- maturation (1)
- mcgraph (1)
- metabolic engineering (1)
- metabolic genomics (1)
- metabolische Modellierung (1)
- metabolism (1)
- metabolite breeding (1)
- metabolite profiling (1)
- metabolome (1)
- metamorphosis (1)
- methane cycle (1)
- methanol assimilation (1)
- microbial processes (1)
- microplastics (1)
- migrants (1)
- migration (1)
- mikrobielle Prozesse (1)
- mini growth spurt (1)
- mining lakes (1)
- molecular species identification (1)
- molybdenum cofactor (1)
- museum specimens (1)
- myocardium (1)
- nanobodies (1)
- nanoelectrodes (1)
- natural particle (1)
- nature of science (1)
- network reconstruction (1)
- neutralization (1)
- nitrate (1)
- nitrogen (1)
- novel biomarkers (1)
- nuclear localization signal (1)
- nucleic acids (1)
- nutrition (1)
- nutritional status (1)
- ob/ob (1)
- p-type ATPase (1)
- pace of life (1)
- paleoclimate (1)
- parentage (1)
- past biosphere (1)
- performance evaluation (1)
- permafrost ecosystems (1)
- phonotaxis (1)
- phosphoproteomics (1)
- photosystem I (1)
- physical fitness (1)
- physical time (1)
- plant secondary metabolites (1)
- playback (1)
- point-of-care (1)
- polyneuropathy (1)
- population dynamics (1)
- pre-service teacher (1)
- predictive models (1)
- professional knowledge (1)
- pubertal timing (1)
- public health (1)
- questioning solutions (1)
- random sampling (1)
- regulation of growth (1)
- repetition (1)
- reproductive success (1)
- resource-tracking (1)
- rotifer (1)
- secular changes (1)
- sedaDNA (1)
- sediment core (1)
- sekundäre Pflanzenstoffe (1)
- seston (1)
- short-term growth (1)
- single domain antibodies (1)
- skeletal age (1)
- social class (1)
- social network (1)
- socioeconomy (1)
- solitary bees (1)
- spatial autocorrelation (1)
- spatially explicit (1)
- spatially explicit model (1)
- standing long jump (1)
- starch granule (1)
- starch granule morphology (1)
- starch granule size (1)
- starch metabolism (1)
- stocking capacity (1)
- sulfite oxidase (1)
- target capture (1)
- thylakoid membranes (1)
- tobacco (1)
- topography (1)
- toxicity (1)
- trace gas fluxes (1)
- transition metals (1)
- translation (1)
- type specimens (1)
- ungulate (1)
- veterinary cordon fence (1)
- virus (1)
- wildlife and habitat management (1)
- zebrafish (1)
- zinc (1)
- Ökologie (1)
- Ökotoxikologie (1)
- Übergangsmetalle (1)
- „Natur der Naturwissenschaften“ (1)
Institute
- Institut für Biochemie und Biologie (74) (remove)
Background: Network models are useful tools for researchers to simplify and understand investigated systems. Yet, the assessment of methods for network construction is often uncertain. Random resampling simulations can aid to assess methods, provided synthetic data exists for reliable network construction.
Objectives: We implemented a new Monte Carlo algorithm to create simulated data for network reconstruction, tested the influence of adjusted parameters and used simulations to select a method for network model estimation based on real-world data. We hypothesized, that reconstructs based on Monte Carlo data are scored at least as good compared to a benchmark.
Methods: Simulated data was generated in R using the Monte Carlo algorithm of the mcgraph package. Benchmark data was created by the huge package. Networks were reconstructed using six estimator functions and scored by four classification metrics. For compatibility tests of mean score differences, Welch’s t-test was used. Network model estimation based on real-world data was done by stepwise selection.
Samples: Simulated data was generated based on 640 input graphs of various types and sizes. The real-world dataset consisted of 67 medieval skeletons of females and males from the region of Refshale (Lolland) and Nordby (Jutland) in Denmark.
Results: Results after t-tests and determining confidence intervals (CI95%) show, that evaluation scores for network reconstructs based on the mcgraph package were at least as good compared to the benchmark huge. The results even indicate slightly better scores on average for the mcgraph package.
Conclusion: The results confirmed our objective and suggested that Monte Carlo data can keep up with the benchmark in the applied test framework. The algorithm offers the feature to use (weighted) un- and directed graphs and might be useful for assessing methods for network construction.
Background: Clinicians often refer anthropometric measures of a child to so-called “growth standards” and “growth references. Over 140 countries have meanwhile adopted WHO growth standards.
Objectives: The present study was conducted to thoroughly examine the idea of growth standards as a common yardstick for all populations. Weight depends on height. We became interested in whether also weight-for-height depends on height. First, we studied the age-group effect on weight-for-height. Thereafter, we tested the applicability of weight-for-height references in short and in historic populations.
Sample and Methods: We analyzed body height and body weight and weight-for-height of 3795 healthy boys and 3726 healthy girls aged 2 to 5 years measured in East-Germany between 1986 and 1990.
We chose contemporary height and weight charts from Germany, the UK, and the WHO growth chart and compared these with three geographically commensurable growth charts from the end of the 19th century.
Results: We analyzed body height and body weight and weight-for-height of 3795 healthy boys and 3726 healthy girls aged 2 to 5 years measured in East-Germany between 1986 and 1990.
We chose contemporary height and weight charts from Germany, the UK, and the WHO growth chart and compared these with three geographically commensurable growth charts of the end of the 19th century.
Conclusion: Weight-for-height depends on age and sex and apart from the nutritional state, reflects body proportion and body built particularly during infancy and early childhood. Populations with a relatively short average height are prone to high values of weight-for-height for arithmetic reasons independent of the nutritional state.
Background: Biological age markers are a crucial indicator whether children are decelerated in growth tempo. Skeletal maturation is the standard measure. Yet, it relies on exposing children to x-radiation. Dental eruption is a potential, but highly debated, radiation free alternative.
Objectives: We assess the interrelationship between dental eruption and other maturational markers. We hypothesize that dental age correlates with body height and skeletal age. We further evaluate how the three different variables behave in cohorts from differing social backgrounds.
Sample and Method: Dental, skeletal and height data from the 1970s to 1990s from Guatemalan boys were converted into standard deviation scores, using external references for each measurement. The boys, aged between 7 and 12, derived from different social backgrounds (middle SES (N = 6529), low-middle SES (N = 736), low SES Ladino (N = 3653) and low SES Maya (N = 4587).
Results: Dental age shows only a weak correlation with skeletal age (0.18) and height (0.2). The distinction between cohorts differs according to each of the three measurements. All cohorts differ significantly in height. In skeletal maturation, the middle SES cohort is significantly advanced compared to all other cohorts. The periodically malnourished cohorts of low SES Mayas and Ladinos are significantly delayed in dental maturation compared to the well-nourished low-middle and middle class Ladino children.
Conclusion: Dental development is an independent system, that is regulated by different mechanisms than skeletal development and growth. Tooth eruption is sensitive to nutritional status, whereas skeletal age is more sensitive to socioeconomic background.
Students learn by repetition. Repetition is essential, but repetition needs questioning, and questioning the repertoire belongs to the essential tasks of student education. Guiding students to questioning was and is our prime motive to offer our International Student Summer Schools. The data were critically discussed among the students, in the twilight of Just So Stories, common knowledge, and prompted questioning of contemporary solutions. For these schools, the students bring their own data, carry their preliminary concepts, and in group discussions, they may have to challenge these concepts. Catch-up growth is known to affect long bone growth, but different opinions exist to what extent it also affects body proportions. Skeletal age and dental development are considered appropriate measures of maturation, but it appears that both system develop independently and are regulated by different mechanisms. Body weight distributions are assumed to be skewed, yet, historic data disproved this assumption. Many discussions focused on current ideas of global growth standards as a common yardstick for all populations world-wide, with new statistical tools being developed including network reconstruction and evaluation of the reconstructs to determine the confidence of graph prediction methods.
125 years ago, European infants grew differently from modern infants. We show weight gains of 20 healthy children weighed longitudinally from birth to age 1 year, published by Camerer in 1882. The data illustrate the historically prevalent concepts of infant nutrition practiced by German civil servants, lawyers, merchants, university professors, physicians, foresters and farmers. Breastfeeding by the mother was not truly appreciated in those days; children were often breastfed by wet nurses or received bottled milk. Bottle feeding mainly used diluted cow’s milk with some added carbohydrates, without evidence that appropriate amounts of oil, butter or other fatty components were added. French children from 1914 showed similar weight gain patterns suggesting similar feeding practices. The historical data suggest that energy deficient infant formula was fed regularly in the late 19th and early 20th century Europe, regardless of wealth and social class. The data question current concerns that temporarily feeding energy deficient infant formula may warrant serious anxieties regarding long-term cognitive, social and emotional behavioral development.
Background: Child growth is a dynamic process. When measured at short intervals, children’s growth shows characteristic patterns that can be of great importance for clinical purposes.
Objective: To study whether measuring height on a daily basis using an APP is practicable and user-friendly.
Methods: Recruitment took place via Snowball Sampling. Thirteen out of 14 contacted families signed up for a study period of 12 weeks with altogether 22 healthy children aged 3 to 13 years (response rate 93%). The study started with a visit to the family home for the setup of the measurement site, conventional height measuring and initial training of the new measurement process. Follow-up appointments were made at four, eight and 12 weeks. The children’s height was measured at daily intervals at their family homes over a period of three months.
Results: The parents altogether recorded 1704 height measurements and meticulously documented practicability and problems when using the device.
A 93% response rate in recruitment was achieved by maintaining a high motivation within the families. Contact with the principal investigator was permanently available, including open communication, personal training and attendance during the appointments at the family homes.
Conclusion: Measuring height by photographic display is interesting for children and parents and can be used for height measurements at home. A positive response rate of 13 out of 14 families with altogether 22 children highlights feasible recruitment and the high convenience and user-friendliness of daily APP-supported height measurements. Daily APP measurements appear to be a promising new tool for longitudinal growth studies.
Wild bee species are important pollinators in agricultural landscapes. However, population decline was reported over the last decades and is still ongoing. While agricultural intensification is a major driver of the rapid loss of pollinating species, transition zones between arable fields and forest or grassland patches, i.e., agricultural buffer zones, are frequently mentioned as suitable mitigation measures to support wild bee populations and other pollinator species. Despite the reported general positive effect, it remains unclear which amount of buffer zones is needed to ensure a sustainable and permanent impact for enhancing bee diversity and abundance. To address this question at a pollinator community level, we implemented a process-based, spatially explicit simulation model of functional bee diversity dynamics in an agricultural landscape. More specifically, we introduced a variable amount of agricultural buffer zones (ABZs) at the transition of arable to grassland, or arable to forest patches to analyze the impact on bee functional diversity and functional richness. We focused our study on solitary bees in a typical agricultural area in the Northeast of Germany. Our results showed positive effects with at least 25% of virtually implemented agricultural buffer zones. However, higher amounts of ABZs of at least 75% should be considered to ensure a sufficient increase in Shannon diversity and decrease in quasi-extinction risks. These high amounts of ABZs represent effective conservation measures to safeguard the stability of pollination services provided by solitary bee species. As the model structure can be easily adapted to other mobile species in agricultural landscapes, our community approach offers the chance to compare the effectiveness of conservation measures also for other pollinator communities in future.
Introduction: The ongoing COVID-19 pandemic situation caused by SARS-CoV-2 and variants of concern such as B.1.617.2 (Delta) and recently, B.1.1.529 (Omicron) is posing multiple challenges to humanity. The rapid evolution of the virus requires adaptation of diagnostic and therapeutic applications.
Objectives: In this study, we describe camelid heavy-chain-only antibodies (hcAb) as useful tools for novel in vitro diagnostic assays and for therapeutic applications due to their neutralizing capacity.
Methods: Five antibody candidates were selected out of a naïve camelid library by phage display and expressed as full length IgG2 antibodies. The antibodies were characterized by Western blot, enzyme-linked immunosorbent assays, surface plasmon resonance with regard to their specificity to the recombinant SARS-CoV-2 Spike protein and to SARS-CoV-2 virus-like particles. Neutralization assays were performed with authentic SARS-CoV-2 and pseudotyped viruses (wildtype and Omicron).
Results: All antibodies efficiently detect recombinant SARS-CoV-2 Spike protein and SARS-CoV-2 virus-like particles in different ELISA setups. The best combination was shown with hcAb B10 as catcher antibody and HRP-conjugated hcAb A7.2 as the detection antibody. Further, four out of five antibodies potently neutralized authentic wildtype SARS-CoV-2 and particles pseudotyped with the SARS-CoV-2 Spike proteins of the wildtype and Omicron variant, sublineage BA.1 at concentrations between 0.1 and 0.35 ng/mL (ND50).
Conclusion: Collectively, we report novel camelid hcAbs suitable for diagnostics and potential therapy.
In semi-arid environments characterized by erratic rainfall and scattered primary production, migratory movements are a key survival strategy of large herbivores to track resources over vast areas. Veterinary Cordon Fences (VCFs), intended to reduce wildlife-livestock disease transmission, fragment large parts of southern Africa and have limited the movements of large wild mammals for over 60 years. Consequently, wildlife-fence interactions are frequent and often result in perforations of the fence, mainly caused by elephants. Yet, we lack knowledge about at which times fences act as barriers, how fences directly alter the energy expenditure of native herbivores, and what the consequences of impermeability are. We studied 2-year ungulate movements in three common antelopes (springbok, kudu, eland) across a perforated part of Namibia's VCF separating a wildlife reserve and Etosha National Park using GPS telemetry, accelerometer measurements, and satellite imagery. We identified 2905 fence interaction events which we used to evaluate critical times of encounters and direct fence effects on energy expenditure. Using vegetation type-specific greenness dynamics, we quantified what animals gained in terms of high quality food resources from crossing the VCF. Our results show that the perforation of the VCF sustains herbivore-vegetation interactions in the savanna with its scattered resources. Fence permeability led to peaks in crossing numbers during the first flush of woody plants before the rain started. Kudu and eland often showed increased energy expenditure when crossing the fence. Energy expenditure was lowered during the frequent interactions of ungulates standing at the fence. We found no alteration of energy expenditure when springbok immediately found and crossed fence breaches. Our results indicate that constantly open gaps did not affect energy expenditure, while gaps with obstacles increased motion. Closing gaps may have confused ungulates and modified their intended movements. While browsing, sedentary kudu's use of space was less affected by the VCF; migratory, mixed-feeding springbok, and eland benefited from gaps by gaining forage quality and quantity after crossing. This highlights the importance of access to vast areas to allow ungulates to track vital vegetation patches.
Environmental pollution by microplastics has become a severe problem in terrestrial and aquatic ecosystems and, according to actual prognoses, problems will further increase in the future. Therefore, assessing and quantifying the risk for the biota is crucial. Standardized short-term toxicological procedures as well as methods quantifying potential toxic effects over the whole life span of an animal are required. We studied the effect of the microplastic polystyrene on the survival and reproduction of a common freshwater invertebrate, the rotifer Brachionus calyciflorus, at different timescales. We used pristine polystyrene spheres of 1, 3, and 6 µm diameter and fed them to the animals together with food algae in different ratios ranging from 0 to 50% nonfood particles. As a particle control, we used silica to distinguish between a pure particle effect and a plastic effect. After 24 h, no toxic effect was found, neither with polystyrene nor with silica. After 96 h, a toxic effect was detectable for both particle types. The size of the particles played a negligible role. Studying the long-term effect by using life table experiments, we found a reduced reproduction when the animals were fed with 3 µm spheres together with similar-sized food algae. We conclude that the fitness reduction is mainly driven by the dilution of food by the nonfood particles rather than by a direct toxic effect.