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Keywords
Abdo, A. A. ; Ackermann, Margit ; Ajello, M. ; Allafort, A. J. ; Baldini, L. ; Ballet, J. ; Barbiellini, G. ; Baring, M. G. ; Bastieri, D. ; Bechtol, K. C. ; Bellazzini, R. ; Berenji, B. ; Blandford, R. D. ; Bloom, E. D. ; Bonamente, E. ; Borgland, A. W. ; Bouvier, A. ; Brandt, T. J. ; Bregeon, Johan ; Brez, A. ; Brigida, M. ; Bruel, P. ; Buehler, R. ; Buson, S. ; Caliandro, G. A. ; Cameron, R. A. ; Cannon, A. ; Caraveo, P. A. ; Carrigan, Svenja ; Casandjian, J. M. ; Cavazzuti, E. ; Cecchi, C. ; Celik, O. ; Charles, E. ; Chekhtman, A. ; Cheung, C. C. ; Chiang, J. ; Ciprini, S. ; Claus, R. ; Cohen-Tanugi, J. ; Conrad, Jan ; Cutini, S. ; Dermer, C. D. ; de Palma, F. ; do Couto e Silva, E. ; Drell, P. S. ; Dubois, R. ; Dumora, D. ; Favuzzi, C. ; Fegan, S. J. ; Ferrara, E. C. ; Focke, W. B. ; Fortin, P. ; Frailis, M. ; Fuhrmann, L. ; Fukazawa, Y. ; Funk, S. ; Fusco, P. ; Gargano, F. ; Gasparrini, D. ; Gehrels, N. ; Germani, S. ; Giglietto, N. ; Giordano, F. ; Giroletti, M. ; Glanzman, T. ; Godfrey, G. ; Grenier, I. A. ; Guillemot, L. ; Guiriec, S. ; Hayashida, M. ; Hays, E. ; Horan, D. ; Hughes, R. E. ; Johannesson, G. ; Johnson, A. S. ; Johnson, W. N. ; Kadler, M. ; Kamae, T. ; Katagiri, H. ; Kataoka, J. ; Knoedlseder, J. ; Kuss, M. ; Lande, J. ; Latronico, L. ; Lee, S. -H. ; Lemoine-Goumard, M. ; Longo, F. ; Loparco, F. ; Lott, B. ; Lovellette, M. N. ; Lubrano, P. ; Madejski, G. M. ; Makeev, A. ; Max-Moerbeck, W. ; Mazziotta, Mario Nicola ; McEnery, J. E. ; Mehault, J. ; Michelson, P. F. ; Mitthumsiri, W. ; Mizuno, T. ; Moiseev, A. A. ; Monte, C. ; Monzani, M. E. ; Morselli, A. ; Moskalenko, I. V. ; Murgia, S. ; Naumann-Godo, M. ; Nishino, S. ; Nolan, P. L. ; Norris, J. P. ; Nuss, E. ; Ohsugi, T. ; Okumura, A. ; Omodei, N. ; Orlando, E. ; Ormes, J. F. ; Paneque, D. ; Panetta, J. H. ; Parent, D. ; Pavlidou, V. ; Pearson, T. J. ; Pelassa, V. ; Pepe, M. ; Pesce-Rollins, M. ; Piron, F. ; Porter, T. A. ; Raino, S. ; Rando, R. ; Razzano, M. ; Readhead, A. ; Reimer, A. ; Reimer, O. ; Richards, J. L. ; Ripken, J. ; Ritz, S. ; Roth, M. ; Sadrozinski, H. F. -W. ; Sanchez, D. ; Sander, A. ; Scargle, J. D. ; Sgro, C. ; Siskind, E. J. ; Smith, P. D. ; Spandre, G. ; Spinelli, P. ; Stawarz, L. ; Stevenson, M. ; Strickman, M. S. ; Sokolovsky, K. V. ; Suson, D. J. ; Takahashi, H. ; Takahashi, T. ; Tanaka, T. ; Thayer, J. B. ; Thayer, J. G. ; Thompson, D. J. ; Tibaldo, L. ; Torres, F. ; Tosti, G. ; Tramacere, A. ; Uchiyama, Y. ; Usher, T. L. ; Vandenbroucke, J. ; Vasileiou, V. ; Vilchez, N. ; Vitale, V. ; Waite, A. P. ; Wang, P. ; Wehrle, A. E. ; Winer, B. L. ; Wood, K. S. ; Yang, Z. ; Ylinen, T. ; Zensus, J. A. ; Ziegler, M. ; Aleksic, J. ; Antonelli, L. A. ; Antoranz, P. ; Backes, Michael ; Barrio, J. A. ; Gonzalez, J. Becerra ; Bednarek, W. ; Berdyugin, A. ; Berger, K. ; Bernardini, E. ; Biland, A. ; Blanch Bigas, O. ; Bock, R. K. ; Boller, A. ; Bonnoli, G. ; Bordas, Pol ; Tridon, D. Borla ; Bosch-Ramon, Valentin ; Bose, D. ; Braun, I. ; Bretz, T. ; Camara, M. ; Carmona, E. ; Carosi, A. ; Colin, P. ; Colombo, E. ; Contreras, J. L. ; Cortina, J. ; Covino, S. ; Dazzi, F. ; de Angelis, A. ; del Pozo, E. De Cea ; De Lotto, B. ; De Maria, M. ; De Sabata, F. ; Mendez, C. Delgado ; Ortega, A. Diago ; Doert, M. ; Dominguez, A. ; Prester, Dijana Dominis ; Dorner, D. ; Doro, M. ; Elsaesser, D. ; Ferenc, D. ; Fonseca, M. V. ; Font, L. ; Lopen, R. J. Garcia ; Garczarczyk, M. ; Gaug, M. ; Giavitto, G. ; Godinovi, N. ; Hadasch, D. ; Herrero, A. ; Hildebrand, D. ; Hoehne-Moench, D. ; Hose, J. ; Hrupec, D. ; Jogler, T. ; Klepser, S. ; Kraehenbuehl, T. ; Kranich, D. ; Krause, J. ; La Barbera, A. ; Leonardo, E. ; Lindfors, E. ; Lombardi, S. ; Lopez, M. ; Lorenz, E. ; Majumdar, P. ; Makariev, E. ; Maneva, G. ; Mankuzhiyil, N. ; Mannheim, K. ; Maraschi, L. ; Mariotti, M. ; Martinez, M. ; Mazin, D. ; Meucci, M. ; Miranda, J. M. ; Mirzoyan, R. ; Miyamoto, H. ; Moldon, J. ; Moralejo, A. ; Nieto, D. ; Nilsson, K. ; Orito, R. ; Oya, I. ; Paoletti, R. ; Paredes, J. M. ; Partini, S. ; Pasanen, M. ; Pauss, F. ; Pegna, R. G. ; Perez-Torres, M. A. ; Persic, M. ; Peruzzo, J. ; Pochon, J. ; Moroni, P. G. Prada ; Prada, F. ; Prandini, E. ; Puchades, N. ; Puljak, I. ; Reichardt, T. ; Reinthal, R. ; Rhode, W. ; Ribo, M. ; Rico, J. ; Rissi, M. ; Ruegamer, S. ; Saggion, A. ; Saito, K. ; Saito, T. Y. ; Salvati, M. ; Sanchez-Conde, M. ; Satalecka, K. ; Scalzotto, V. ; Scapin, V. ; Schultz, C. ; Schweizer, T. ; Shayduk, M. ; Shore, S. N. ; Sierpowska-Bartosik, A. ; Sillanpaa, A. ; Sitarek, J. ; Sobczynska, D. ; Spanier, F. ; Spiro, S. ; Stamerra, A. ; Steinke, B. ; Storz, J. ; Strah, N. ; Struebig, J. C. ; Suric, T. ; Takalo, L. O. ; Tavecchio, F. ; Temnikov, P. ; Terzic, T. ; Tescaro, D. ; Teshima, M. ; Vankov, H. ; Wagner, R. M. ; Weitzel, Q. ; Zabalza, V. ; Zandanel, F. ; Zanin, R. ; Acciari, V. A. ; Arlen, T. ; Aune, T. ; Benbow, W. ; Boltuch, D. ; Bradbury, S. M. ; Buckley, J. H. ; Bugaev, V. ; Cannon, A. ; Cesarini, A. ; Ciupik, L. ; Cui, W. ; Dickherber, R. ; Errando, M. ; Falcone, A. ; Finley, J. P. ; Finnegan, G. ; Fortson, L. ; Furniss, A. ; Galante, N. ; Gall, D. ; Gillanders, G. H. ; Godambe, S. ; Grube, J. ; Guenette, R. ; Gyuk, G. ; Hanna, D. ; Holder, J. ; Huang, D. ; Hui, C. M. ; Humensky, T. B. ; Kaaret, P. ; Karlsson, N. ; Kertzman, M. ; Kieda, D. ; Konopelko, A. ; Krawczynski, H. ; Krennrich, F. ; Lang, M. J. ; Maier, G. ; McArthur, S. ; McCann, A. ; McCutcheon, M. ; Moriarty, P. ; Mukherjee, R. ; Ong, R. ; Otte, N. ; Pandel, D. ; Perkins, J. S. ; Pichel, A. ; Pohl, M. ; Quinn, J. ; Ragan, K. ; Reyes, L. C. ; Reynolds, P. T. ; Roache, E. ; Rose, H. J. ; Rovero, A. C. ; Schroedter, M. ; Sembroski, G. H. ; Senturk, G. D. ; Steele, D. ; Swordy, S. P. ; Tesic, G. ; Theiling, M. ; Thibadeau, S. ; Varlotta, A. ; Vincent, S. ; Wakely, S. P. ; Ward, J. E. ; Weekes, T. C. ; Weinstein, A. ; Weisgarber, T. ; Williams, D. A. ; Wood, M. ; Zitzer, B. ; Villata, M. ; Raiteri, C. M. ; Aller, H. D. ; Aller, M. F. ; Arkharov, A. A. ; Blinov, D. A. ; Calcidese, P. ; Chen, W. P. ; Efimova, N. V. ; Kimeridze, G. ; Konstantinova, T. S. ; Kopatskaya, E. N. ; Koptelova, E. ; Kurtanidze, O. M. ; Kurtanidze, S. O. ; Lahteenmaki, A. ; Larionov, V. M. ; Larionova, E. G. ; Larionova, L. V. ; Ligustri, R. ; Morozova, D. A. ; Nikolashvili, M. G. ; Sigua, L. A. ; Troitsky, I. S. ; Angelakis, E. ; Capalbi, M. ; Carraminana, A. ; Carrasco, L. ; Cassaro, P. ; de la Fuente, E. ; Gurwell, M. A. ; Kovalev, Y. Y. ; Kovalev, Yu. A. ; Krichbaum, T. P. ; Krimm, H. A. ; Leto, Paolo ; Lister, M. L. ; Maccaferri, G. ; Moody, J. W. ; Mori, Y. ; Nestoras, I. ; Orlati, A. ; Pagani, C. ; Pace, C. ; Pearson, R. ; Perri, M. ; Piner, B. G. ; Pushkarev, A. B. ; Ros, E. ; Sadun, A. C. ; Sakamoto, T. ; Tornikoski, M. ; Yatsu, Y. ; Zook, A.
We report on the gamma-ray activity of the blazar Mrk 501 during the first 480 days of Fermi operation. We find that the average Large Area Telescope (LAT) gamma-ray spectrum of Mrk 501 can be well described by a single power-law function with a photon index of 1.78 +/- 0.03. While we observe relatively mild flux variations with the Fermi-LAT (within less than a factor of two), we detect remarkable spectral variability where the hardest observed spectral index within the LAT energy range is 1.52 +/- 0.14, and the softest one is 2.51 +/- 0.20. These unexpected spectral changes do not correlate with the measured flux variations above 0.3 GeV. In this paper, we also present the first results from the 4.5 month long multifrequency campaign (2009 March 15-August 1) on Mrk 501, which included the Very Long Baseline Array (VLBA), Swift, RXTE, MAGIC, and VERITAS, the F-GAMMA, GASP-WEBT, and other collaborations and instruments which provided excellent temporal and energy coverage of the source throughout the entire campaign. The extensive radio to TeV data set from this campaign provides us with the most detailed spectral energy distribution yet collected for this source during its relatively low activity. The average spectral energy distribution of Mrk 501 is well described by the standard one-zone synchrotron self-Compton (SSC) model. In the framework of this model, we find that the dominant emission region is characterized by a size less than or similar to 0.1 pc (comparable within a factor of few to the size of the partially resolved VLBA core at 15-43 GHz), and that the total jet power (similar or equal to 10(44) erg s(-1)) constitutes only a small fraction (similar to 10(-3)) of the Eddington luminosity. The energy distribution of the freshly accelerated radiating electrons required to fit the time-averaged data has a broken power-law form in the energy range 0.3 GeV-10 TeV, with spectral indices 2.2 and 2.7 below and above the break energy of 20 GeV. We argue that such a form is consistent with a scenario in which the bulk of the energy dissipation within the dominant emission zone of Mrk 501 is due to relativistic, proton-mediated shocks. We find that the ultrarelativistic electrons and mildly relativistic protons within the blazar zone, if comparable in number, are in approximate energy equipartition, with their energy dominating the jet magnetic field energy by about two orders of magnitude.
Wartenberg, Maria ; Budde, Paula ; de Mareés, M. ; Tsang, S. Y. ; Huang, Y. ; Chen, Zhen-Yu ; Hescheler, Jürgen ; Sauer, Heinrich
A catalog of genetic loci associated with kidney function from analyses of a million individuals
(2019)
Wuttke, Matthias ; Li, Yong ; Li, Man ; Sieber, Karsten B. ; Feitosa, Mary F. ; Gorski, Mathias ; Tin, Adrienne ; Wang, Lihua ; Chu, Audrey Y. ; Hoppmann, Anselm ; Kirsten, Holger ; Giri, Ayush ; Chai, Jin-Fang ; Sveinbjornsson, Gardar ; Tayo, Bamidele O. ; Nutile, Teresa ; Fuchsberger, Christian ; Marten, Jonathan ; Cocca, Massimiliano ; Ghasemi, Sahar ; Xu, Yizhe ; Horn, Katrin ; Noce, Damia ; Van der Most, Peter J. ; Sedaghat, Sanaz ; Yu, Zhi ; Akiyama, Masato ; Afaq, Saima ; Ahluwalia, Tarunveer Singh ; Almgren, Peter ; Amin, Najaf ; Arnlov, Johan ; Bakker, Stephan J. L. ; Bansal, Nisha ; Baptista, Daniela ; Bergmann, Sven ; Biggs, Mary L. ; Biino, Ginevra ; Boehnke, Michael ; Boerwinkle, Eric ; Boissel, Mathilde ; Böttinger, Erwin ; Boutin, Thibaud S. ; Brenner, Hermann ; Brumat, Marco ; Burkhardt, Ralph ; Butterworth, Adam S. ; Campana, Eric ; Campbell, Archie ; Campbell, Harry ; Canouil, Mickael ; Carroll, Robert J. ; Catamo, Eulalia ; Chambers, John C. ; Chee, Miao-Ling ; Chee, Miao-Li ; Chen, Xu ; Cheng, Ching-Yu ; Cheng, Yurong ; Christensen, Kaare ; Cifkova, Renata ; Ciullo, Marina ; Concas, Maria Pina ; Cook, James P. ; Coresh, Josef ; Corre, Tanguy ; Sala, Cinzia Felicita ; Cusi, Daniele ; Danesh, John ; Daw, E. Warwick ; De Borst, Martin H. ; De Grandi, Alessandro ; De Mutsert, Renee ; De Vries, Aiko P. J. ; Degenhardt, Frauke ; Delgado, Graciela ; Demirkan, Ayse ; Di Angelantonio, Emanuele ; Dittrich, Katalin ; Divers, Jasmin ; Dorajoo, Rajkumar ; Eckardt, Kai-Uwe ; Ehret, Georg ; Elliott, Paul ; Endlich, Karlhans ; Evans, Michele K. ; Felix, Janine F. ; Foo, Valencia Hui Xian ; Franco, Oscar H. ; Franke, Andre ; Freedman, Barry I. ; Freitag-Wolf, Sandra ; Friedlander, Yechiel ; Froguel, Philippe ; Gansevoort, Ron T. ; Gao, He ; Gasparini, Paolo ; Gaziano, J. Michael ; Giedraitis, Vilmantas ; Gieger, Christian ; Girotto, Giorgia ; Giulianini, Franco ; Gogele, Martin ; Gordon, Scott D. ; Gudbjartsson, Daniel F. ; Gudnason, Vilmundur ; Haller, Toomas ; Hamet, Pavel ; Harris, Tamara B. ; Hartman, Catharina A. ; Hayward, Caroline ; Hellwege, Jacklyn N. ; Heng, Chew-Kiat ; Hicks, Andrew A. ; Hofer, Edith ; Huang, Wei ; Hutri-Kahonen, Nina ; Hwang, Shih-Jen ; Ikram, M. Arfan ; Indridason, Olafur S. ; Ingelsson, Erik ; Ising, Marcus ; Jaddoe, Vincent W. V. ; Jakobsdottir, Johanna ; Jonas, Jost B. ; Joshi, Peter K. ; Josyula, Navya Shilpa ; Jung, Bettina ; Kahonen, Mika ; Kamatani, Yoichiro ; Kammerer, Candace M. ; Kanai, Masahiro ; Kastarinen, Mika ; Kerr, Shona M. ; Khor, Chiea-Chuen ; Kiess, Wieland ; Kleber, Marcus E. ; Koenig, Wolfgang ; Kooner, Jaspal S. ; Korner, Antje ; Kovacs, Peter ; Kraja, Aldi T. ; Krajcoviechova, Alena ; Kramer, Holly ; Kramer, Bernhard K. ; Kronenberg, Florian ; Kubo, Michiaki ; Kuhnel, Brigitte ; Kuokkanen, Mikko ; Kuusisto, Johanna ; La Bianca, Martina ; Laakso, Markku ; Lange, Leslie A. ; Langefeld, Carl D. ; Lee, Jeannette Jen-Mai ; Lehne, Benjamin ; Lehtimaki, Terho ; Lieb, Wolfgang ; Lim, Su-Chi ; Lind, Lars ; Lindgren, Cecilia M. ; Liu, Jun ; Liu, Jianjun ; Loeffler, Markus ; Loos, Ruth J. F. ; Lucae, Susanne ; Lukas, Mary Ann ; Lyytikainen, Leo-Pekka ; Magi, Reedik ; Magnusson, Patrik K. E. ; Mahajan, Anubha ; Martin, Nicholas G. ; Martins, Jade ; Marz, Winfried ; Mascalzoni, Deborah ; Matsuda, Koichi ; Meisinger, Christa ; Meitinger, Thomas ; Melander, Olle ; Metspalu, Andres ; Mikaelsdottir, Evgenia K. ; Milaneschi, Yuri ; Miliku, Kozeta ; Mishra, Pashupati P. ; Program, V. A. Million Veteran ; Mohlke, Karen L. ; Mononen, Nina ; Montgomery, Grant W. ; Mook-Kanamori, Dennis O. ; Mychaleckyj, Josyf C. ; Nadkarni, Girish N. ; Nalls, Mike A. ; Nauck, Matthias ; Nikus, Kjell ; Ning, Boting ; Nolte, Ilja M. ; Noordam, Raymond ; Olafsson, Isleifur ; Oldehinkel, Albertine J. ; Orho-Melander, Marju ; Ouwehand, Willem H. ; Padmanabhan, Sandosh ; Palmer, Nicholette D. ; Palsson, Runolfur ; Penninx, Brenda W. J. H. ; Perls, Thomas ; Perola, Markus ; Pirastu, Mario ; Pirastu, Nicola ; Pistis, Giorgio ; Podgornaia, Anna I. ; Polasek, Ozren ; Ponte, Belen ; Porteous, David J. ; Poulain, Tanja ; Pramstaller, Peter P. ; Preuss, Michael H. ; Prins, Bram P. ; Province, Michael A. ; Rabelink, Ton J. ; Raffield, Laura M. ; Raitakari, Olli T. ; Reilly, Dermot F. ; Rettig, Rainer ; Rheinberger, Myriam ; Rice, Kenneth M. ; Ridker, Paul M. ; Rivadeneira, Fernando ; Rizzi, Federica ; Roberts, David J. ; Robino, Antonietta ; Rossing, Peter ; Rudan, Igor ; Rueedi, Rico ; Ruggiero, Daniela ; Ryan, Kathleen A. ; Saba, Yasaman ; Sabanayagam, Charumathi ; Salomaa, Veikko ; Salvi, Erika ; Saum, Kai-Uwe ; Schmidt, Helena ; Schmidt, Reinhold ; Ben Schottker ; Schulz, Christina-Alexandra ; Schupf, Nicole ; Shaffer, Christian M. ; Shi, Yuan ; Smith, Albert V. ; Smith, Blair H. ; Soranzo, Nicole ; Spracklen, Cassandra N. ; Strauch, Konstantin ; Stringham, Heather M. ; Stumvoll, Michael ; Svensson, Per O. ; Szymczak, Silke ; Tai, E-Shyong ; Tajuddin, Salman M. ; Tan, Nicholas Y. Q. ; Taylor, Kent D. ; Teren, Andrej ; Tham, Yih-Chung ; Thiery, Joachim ; Thio, Chris H. L. ; Thomsen, Hauke ; Thorleifsson, Gudmar ; Toniolo, Daniela ; Tonjes, Anke ; Tremblay, Johanne ; Tzoulaki, Ioanna ; Uitterlinden, Andre G. ; Vaccargiu, Simona ; Van Dam, Rob M. ; Van der Harst, Pim ; Van Duijn, Cornelia M. ; Edward, Digna R. Velez ; Verweij, Niek ; Vogelezang, Suzanne ; Volker, Uwe ; Vollenweider, Peter ; Waeber, Gerard ; Waldenberger, Melanie ; Wallentin, Lars ; Wang, Ya Xing ; Wang, Chaolong ; Waterworth, Dawn M. ; Bin Wei, Wen ; White, Harvey ; Whitfield, John B. ; Wild, Sarah H. ; Wilson, James F. ; Wojczynski, Mary K. ; Wong, Charlene ; Wong, Tien-Yin ; Xu, Liang ; Yang, Qiong ; Yasuda, Masayuki ; Yerges-Armstrong, Laura M. ; Zhang, Weihua ; Zonderman, Alan B. ; Rotter, Jerome I. ; Bochud, Murielle ; Psaty, Bruce M. ; Vitart, Veronique ; Wilson, James G. ; Dehghan, Abbas ; Parsa, Afshin ; Chasman, Daniel I. ; Ho, Kevin ; Morris, Andrew P. ; Devuyst, Olivier ; Akilesh, Shreeram ; Pendergrass, Sarah A. ; Sim, Xueling ; Boger, Carsten A. ; Okada, Yukinori ; Edwards, Todd L. ; Snieder, Harold ; Stefansson, Kari ; Hung, Adriana M. ; Heid, Iris M. ; Scholz, Markus ; Teumer, Alexander ; Kottgen, Anna ; Pattaro, Cristian
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
Abeysekara, A. U. ; Archer, A. ; Aune, Taylor ; Benbow, Wystan ; Bird, Ralph ; Brose, Robert ; Buchovecky, M. ; Bugaev, V. ; Cui, Wei ; Daniel, M. K. ; Falcone, A. ; Feng, Qi ; Finley, John P. ; Fleischhack, H. ; Flinders, A. ; Fortson, L. ; Furniss, Amy ; Gotthelf, Eric V. ; Grube, J. ; Hanna, David ; Hervet, O. ; Holder, J. ; Huang, K. ; Hughes, G. ; Humensky, T. B. ; Huetten, M. ; Johnson, Caitlin A. ; Kaaret, Philip ; Kar, P. ; Kelley-Hoskins, N. ; Kertzman, M. ; Kieda, David ; Krause, Maria ; Kumar, S. ; Lang, M. J. ; Lin, T. T. Y. ; Maier, Gernot ; McArthur, S. ; Moriarty, P. ; Mukherjee, Reshmi ; Ong, R. A. ; Otte, Adam Nepomuk ; Pandel, Dirk ; Park, Nahee ; Petrashyk, A. ; Pohl, Martin ; Popkow, Alexis ; Pueschel, Elisa ; Quinn, J. ; Ragan, K. ; Reynolds, P. T. ; Richards, Gregory T. ; Roache, E. ; Rousselle, J. ; Rulten, C. ; Sadeh, I. ; Santander, M. ; Sembroski, G. H. ; Shahinyan, Karlen ; Tyler, J. ; Vassiliev, V. V. ; Wakely, S. P. ; Ward, J. E. ; Weinstein, A. ; Wells, R. M. ; Wilcox, P. ; Wilhelm, Alina ; Williams, David A. ; Zitzer, B.
We present results from deep observations toward the Cygnus region using 300 hr of very high energy (VHE)gamma-ray data taken with the VERITAS Cerenkov telescope array and over 7 yr of high-energy.-ray data taken with the Fermi satellite at an energy above 1 GeV. As the brightest region of diffuse gamma-ray emission in the northern sky, the Cygnus region provides a promising area to probe the origins of cosmic rays. We report the identification of a potential Fermi-LAT counterpart to VER J2031+415 (TeV J2032+4130) and resolve the extended VHE source VER J2019+368 into two source candidates (VER J2018+367* and VER J2020+368*) and characterize their energy spectra. The Fermi-LAT morphology of 3FGL J2021.0+4031e (the Gamma Cygni supernova remnant) was examined, and a region of enhanced emission coincident with VER J2019+407 was identified and jointly fit with the VERITAS data. By modeling 3FGL J2015.6+3709 as two sources, one located at the location of the pulsar wind nebula CTB 87 and one at the quasar QSO J2015+371, a continuous spectrum from 1 GeV to 10 TeV was extracted for VER J2016+371 (CTB 87). An additional 71 locations coincident with Fermi-LAT sources and other potential objects of interest were tested for VHE gamma-ray emission, with no emission detected and upper limits on the differential flux placed at an average of 2.3% of the Crab Nebula flux. We interpret these observations in a multiwavelength context and present the most detailed gamma-ray view of the region to date.
Brodeur, Abel ; Mikola, Derek ; Cook, Nikolai ; Brailey, Thomas ; Briggs, Ryan ; Gendre, Alexandra de ; Dupraz, Yannick ; Fiala, Lenka ; Gabani, Jacopo ; Gauriot, Romain ; Haddad, Joanne ; Lima, Goncalo ; Ankel-Peters, Jörg ; Dreber, Anna ; Campbell, Douglas ; Kattan, Lamis ; Fages, Diego Marino ; Mierisch, Fabian ; Sun, Pu ; Wright, Taylor ; Connolly, Marie ; Hoces de la Guardia, Fernando ; Johannesson, Magnus ; Miguel, Edward ; Vilhuber, Lars ; Abarca, Alejandro ; Acharya, Mahesh ; Adjisse, Sossou Simplice ; Akhtar, Ahwaz ; Lizardi, Eduardo Alberto Ramirez ; Albrecht, Sabina ; Andersen, Synve Nygaard ; Andlib, Zubaria ; Arrora, Falak ; Ash, Thomas ; Bacher, Etienne ; Bachler, Sebastian ; Bacon, Félix ; Bagues, Manuel ; Balogh, Timea ; Batmanov, Alisher ; Barschkett, Mara ; Basdil, B. Kaan ; Dower, Jaromneda ; Castek, Ondrej ; Caviglia-Harris, Jill ; Strand, Gabriella Chauca ; Chen, Shi ; Chzhen, Asya ; Chung, Jong ; Collins, Jason ; Coppock, Alexander ; Cordeau, Hugo ; Couillard, Ben ; Crechet, Jonathan ; Crippa, Lorenzo ; Cui, Jeanne ; Czymara, Christian ; Daarstad, Haley ; Dao, Danh Chi ; Dao, Dong ; Schmandt, Marco David ; Linde, Astrid de ; Melo, Lucas De ; Deer, Lachlan ; Vera, Micole De ; Dimitrova, Velichka ; Dollbaum, Jan Fabian ; Dollbaum, Jan Matti ; Donnelly, Michael ; Huynh, Luu Duc Toan ; Dumbalska, Tsvetomira ; Duncan, Jamie ; Duong, Kiet Tuan ; Duprey, Thibaut ; Dworschak, Christoph ; Ellingsrud, Sigmund ; Elminejad, Ali ; Eissa, Yasmine ; Erhart, Andrea ; Etingin-Frati, Giulian ; Fatemi-Pour, Elaheh ; Federice, Alexa ; Feld, Jan ; Fenig, Guidon ; Firouzjaeiangalougah, Mojtaba ; Fleisje, Erlend ; Fortier-Chouinard, Alexandre ; Engel, Julia Francesca ; Fries, Tilman ; Fortier, Reid ; Fréchet, Nadjim ; Galipeau, Thomas ; Gallegos, Sebastián ; Gangji, Areez ; Gao, Xiaoying ; Garnache, Cloé ; Gáspár, Attila ; Gavrilova, Evelina ; Ghosh, Arijit ; Gibney, Garreth ; Gibson, Grant ; Godager, Geir ; Goff, Leonard ; Gong, Da ; González, Javier ; Gretton, Jeremy ; Griffa, Cristina ; Grigoryeva, Idaliya ; Grtting, Maja ; Guntermann, Eric ; Guo, Jiaqi ; Gugushvili, Alexi ; Habibnia, Hooman ; Häffner, Sonja ; Hall, Jonathan D. ; Hammar, Olle ; Kordt, Amund Hanson ; Hashimoto, Barry ; Hartley, Jonathan S. ; Hausladen, Carina I. ; Havránek, Tomáš ; Hazen, Jacob ; He, Harry ; Hepplewhite, Matthew ; Herrera-Rodriguez, Mario ; Heuer, Felix ; Heyes, Anthony ; Ho, Anson T. Y. ; Holmes, Jonathan ; Holzknecht, Armando ; Hsu, Yu-Hsiang Dexter ; Hu, Shiang-Hung ; Huang, Yu-Shiuan ; Huebener, Mathias ; Huber, Christoph ; Huynh, Kim P. ; Irsova, Zuzana ; Isler, Ozan ; Jakobsson, Niklas ; Frith, Michael James ; Jananji, Raphaël ; Jayalath, Tharaka A. ; Jetter, Michael ; John, Jenny ; Forshaw, Rachel Joy ; Juan, Felipe ; Kadriu, Valon ; Karim, Sunny ; Kelly, Edmund ; Dang, Duy Khanh Hoang ; Khushboo, Tazia ; Kim, Jin ; Kjellsson, Gustav ; Kjelsrud, Anders ; Kotsadam, Andreas ; Korpershoek, Jori ; Krashinsky, Lewis ; Kundu, Suranjana ; Kustov, Alexander ; Lalayev, Nurlan ; Langlois, Audrée ; Laufer, Jill ; Lee-Whiting, Blake ; Leibing, Andreas ; Lenz, Gabriel ; Levin, Joel ; Li, Peng ; Li, Tongzhe ; Lin, Yuchen ; Listo, Ariel ; Liu, Dan ; Lu, Xuewen ; Lukmanova, Elvina ; Luscombe, Alex ; Lusher, Lester R. ; Lyu, Ke ; Ma, Hai ; Mäder, Nicolas ; Makate, Clifton ; Malmberg, Alice ; Maitra, Adit ; Mandas, Marco ; Marcus, Jan ; Margaryan, Shushanik ; Márk, Lili ; Martignano, Andres ; Marsh, Abigail ; Masetto, Isabella ; McCanny, Anthony ; McManus, Emma ; McWay, Ryan ; Metson, Lennard ; Kinge, Jonas Minet ; Mishra, Sumit ; Mohnen, Myra ; Möller, Jakob ; Montambeault, Rosalie ; Montpetit, Sébastien ; Morin, Louis-Philippe ; Morris, Todd ; Moser, Scott ; Motoki, Fabio ; Muehlenbachs, Lucija ; Musulan, Andreea ; Musumeci, Marco ; Nabin, Munirul ; Nchare, Karim ; Neubauer, Florian ; Nguyen, Quan M. P. ; Nguyen, Tuan ; Nguyen-Tien, Viet ; Niazi, Ali ; Nikolaishvili, Giorgi ; Nordstrom, Ardyn ; Nü, Patrick ; Odermatt, Angela ; Olson, Matt ; ien, Henning ; Ölkers, Tim ; Vert, Miquel Oliver i. ; Oral, Emre ; Oswald, Christian ; Ousman, Ali ; Özak, Ömer ; Pandey, Shubham ; Pavlov, Alexandre ; Pelli, Martino ; Penheiro, Romeo ; Park, RyuGyung ; Martel, Eva Pérez ; Petrovičová, Tereza ; Phan, Linh ; Prettyman, Alexa ; Procházka, Jakub ; Putri, Aqila ; Quandt, Julian ; Qiu, Kangyu ; Nguyen, Loan Quynh Thi ; Rahman, Andaleeb ; Rea, Carson H. ; Reiremo, Adam ; Renée, Laëtitia ; Richardson, Joseph ; Rivers, Nicholas ; Rodrigues, Bruno ; Roelofs, William ; Roemer, Tobias ; Rogeberg, Ole ; Rose, Julian ; Roskos-Ewoldsen, Andrew ; Rosmer, Paul ; Sabada, Barbara ; Saberian, Soodeh ; Salamanca, Nicolas ; Sator, Georg ; Sawyer, Antoine ; Scates, Daniel ; Schlüter, Elmar ; Sells, Cameron ; Sen, Sharmi ; Sethi, Ritika ; Shcherbiak, Anna ; Sogaolu, Moyosore ; Soosalu, Matt ; Srensen, Erik ; Sovani, Manali ; Spencer, Noah ; Staubli, Stefan ; Stans, Renske ; Stewart, Anya ; Stips, Felix ; Stockley, Kieran ; Strobel, Stephenson ; Struby, Ethan ; Tang, John ; Tanrisever, Idil ; Yang, Thomas Tao ; Tastan, Ipek ; Tatić, Dejan ; Tatlow, Benjamin ; Seuyong, Féraud Tchuisseu ; Thériault, Rémi ; Thivierge, Vincent ; Tian, Wenjie ; Toma, Filip-Mihai ; Totarelli, Maddalena ; Tran, Van-Anh ; Truong, Hung ; Tsoy, Nikita ; Tuzcuoglu, Kerem ; Ubfal, Diego ; Villalobos, Laura ; Walterskirchen, Julian ; Wang, Joseph Taoyi ; Wattal, Vasudha ; Webb, Matthew D. ; Weber, Bryan ; Weisser, Reinhard ; Weng, Wei-Chien ; Westheide, Christian ; White, Kimberly ; Winter, Jacob ; Wochner, Timo ; Woerman, Matt ; Wong, Jared ; Woodard, Ritchie ; Wroński, Marcin ; Yazbeck, Myra ; Yang, Gustav Chung ; Yap, Luther ; Yassin, Kareman ; Ye, Hao ; Yoon, Jin Young ; Yurris, Chris ; Zahra, Tahreen ; Zaneva, Mirela ; Zayat, Aline ; Zhang, Jonathan ; Zhao, Ziwei ; Yaolang, Zhong
This study pushes our understanding of research reliability by reproducing and replicating claims from 110 papers in leading economic and political science journals. The analysis involves computational reproducibility checks and robustness assessments. It reveals several patterns. First, we uncover a high rate of fully computationally reproducible results (over 85%). Second, excluding minor issues like missing packages or broken pathways, we uncover coding errors for about 25% of studies, with some studies containing multiple errors. Third, we test the robustness of the results to 5,511 re-analyses. We find a robustness reproducibility of about 70%. Robustness reproducibility rates are relatively higher for re-analyses that introduce new data and lower for re-analyses that change the sample or the definition of the dependent variable. Fourth, 52% of re-analysis effect size estimates are smaller than the original published estimates and the average statistical significance of a re-analysis is 77% of the original. Lastly, we rely on six teams of researchers working independently to answer eight additional research questions on the determinants of robustness reproducibility. Most teams find a negative relationship between replicators' experience and reproducibility, while finding no relationship between reproducibility and the provision of intermediate or even raw data combined with the necessary cleaning codes.
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