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van Driel-Gesztelyi, L. ; Baker, Daniel N. ; Toeroek, T. ; Pariat, E. ; Green, L. M. ; Williams, D. R. ; Carlyle, J. ; Valori, G. ; Demoulin, Pascal ; Kliem, Bernhard ; Long, D. M. ; Matthews, S. A. ; Malherbe, J. -M.
Coronal mass ejections (CMEs) erupt and expand in a magnetically structured solar corona. Various indirect observational pieces of evidence have shown that the magnetic field of CMEs reconnects with surrounding magnetic fields, forming, e.g., dimming regions distant from the CME source regions. Analyzing Solar Dynamics Observatory (SDO) observations of the eruption from AR 11226 on 2011 June 7, we present the first direct evidence of coronal magnetic reconnection between the fields of two adjacent active regions during a CME. The observations are presented jointly with a data-constrained numerical simulation, demonstrating the formation/intensification of current sheets along a hyperbolic flux tube at the interface between the CME and the neighboring AR 11227. Reconnection resulted in the formation of new magnetic connections between the erupting magnetic structure from AR 11226 and the neighboring active region AR 11227 about 200 Mm from the eruption site. The onset of reconnection first becomes apparent in the SDO/AIA images when filament plasma, originally contained within the erupting flux rope, is redirected toward remote areas in AR 11227, tracing the change of large-scale magnetic connectivity. The location of the coronal reconnection region becomes bright and directly observable at SDO/AIA wavelengths, owing to the presence of down-flowing cool, dense (1010 cm(-3)) filament plasma in its vicinity. The high-density plasma around the reconnection region is heated to coronal temperatures, presumably by slow-mode shocks and Coulomb collisions. These results provide the first direct observational evidence that CMEs reconnect with surrounding magnetic structures, leading to a large-scale reconfiguration of the coronal magnetic field.
Treat, Claire C. ; Kleinen, Thomas ; Broothaerts, Nils ; Dalton, April S. ; Dommain, Rene ; Douglas, Thomas A. ; Drexler, Judith Z. ; Finkelstein, Sarah A. ; Grosse, Guido ; Hope, Geoffrey ; Hutchings, Jack ; Jones, Miriam C. ; Kuhry, Peter ; Lacourse, Terri ; Lahteenoja, Outi ; Loisel, Julie ; Notebaert, Bastiaan ; Payne, Richard J. ; Peteet, Dorothy M. ; Sannel, A. Britta K. ; Stelling, Jonathan M. ; Strauss, Jens ; Swindles, Graeme T. ; Talbot, Julie ; Tarnocai, Charles ; Verstraeten, Gert ; Williams, Christopher J. ; Xia, Zhengyu ; Yu, Zicheng ; Valiranta, Minna ; Hattestrand, Martina ; Alexanderson, Helena ; Brovkin, Victor
Glacial-interglacial variations in CO2 and methane in polar ice cores have been attributed, in part, to changes in global wetland extent, but the wetland distribution before the Last Glacial Maximum (LGM, 21 ka to 18 ka) remains virtually unknown. We present a study of global peatland extent and carbon (C) stocks through the last glacial cycle (130 ka to present) using a newly compiled database of 1,063 detailed stratigraphic records of peat deposits buried by mineral sediments, as well as a global peatland model. Quantitative agreement between modeling and observations shows extensive peat accumulation before the LGM in northern latitudes (> 40 degrees N), particularly during warmer periods including the last interglacial (130 ka to 116 ka, MIS 5e) and the interstadial (57 ka to 29 ka, MIS 3). During cooling periods of glacial advance and permafrost formation, the burial of northern peatlands by glaciers and mineral sediments decreased active peatland extent, thickness, and modeled C stocks by 70 to 90% from warmer times. Tropical peatland extent and C stocks show little temporal variation throughout the study period. While the increased burial of northern peats was correlated with cooling periods, the burial of tropical peat was predominately driven by changes in sea level and regional hydrology. Peat burial by mineral sediments represents a mechanism for long-term terrestrial C storage in the Earth system. These results show that northern peatlands accumulate significant C stocks during warmer times, indicating their potential for C sequestration during the warming Anthropocene.
Toy, Virginia Gail ; Sutherland, Rupert ; Townend, John ; Allen, Michael J. ; Becroft, Leeza ; Boles, Austin ; Boulton, Carolyn ; Carpenter, Brett ; Cooper, Alan ; Cox, Simon C. ; Daube, Christopher ; Faulkner, D. R. ; Halfpenny, Angela ; Kato, Naoki ; Keys, Stephen ; Kirilova, Martina ; Kometani, Yusuke ; Little, Timothy ; Mariani, Elisabetta ; Melosh, Benjamin ; Menzies, Catriona D. ; Morales, Luiz ; Morgan, Chance ; Mori, Hiroshi ; Niemeijer, Andre ; Norris, Richard ; Prior, David ; Sauer, Katrina ; Schleicher, Anja Maria ; Shigematsu, Norio ; Teagle, Damon A. H. ; Tobin, Harold ; Valdez, Robert ; Williams, Jack ; Yeo, Samantha ; Baratin, Laura-May ; Barth, Nicolas ; Benson, Adrian ; Boese, Carolin ; Célérier, Bernard ; Chamberlain, Calum J. ; Conze, Ronald ; Coussens, Jamie ; Craw, Lisa ; Doan, Mai-Linh ; Eccles, Jennifer ; Grieve, Jason ; Grochowski, Julia ; Gulley, Anton ; Howarth, Jamie ; Jacobs, Katrina ; Janku-Capova, Lucie ; Jeppson, Tamara ; Langridge, Robert ; Mallyon, Deirdre ; Marx, Ray ; Massiot, Cécile ; Mathewson, Loren ; Moore, Josephine ; Nishikawa, Osamu ; Pooley, Brent ; Pyne, Alex ; Savage, Martha K. ; Schmitt, Doug ; Taylor-Offord, Sam ; Upton, Phaedra ; Weaver, Konrad C. ; Wiersberg, Thomas ; Zimmer, Martin
During the second phase of the Alpine Fault, Deep Fault Drilling Project (DFDP) in the Whataroa River, South Westland, New Zealand, bedrock was encountered in the DFDP-2B borehole from 238.5–893.2 m Measured Depth (MD). Continuous sampling and meso- to microscale characterisation of whole rock cuttings established that, in sequence, the borehole sampled amphibolite facies, Torlesse Composite Terrane-derived schists, protomylonites and mylonites, terminating 200–400 m above an Alpine Fault Principal Slip Zone (PSZ) with a maximum dip of 62°. The most diagnostic structural features of increasing PSZ proximity were the occurrence of shear bands and reduction in mean quartz grain sizes. A change in composition to greater mica:quartz + feldspar, most markedly below c. 700 m MD, is inferred to result from either heterogeneous sampling or a change in lithology related to alteration. Major oxide variations suggest the fault-proximal Alpine Fault alteration zone, as previously defined in DFDP-1 core, was not sampled.
Thiede, Rasmus Christoph ; Arrowsmith, J. Ramón ; Bookhagen, Bodo ; McWilliams, Michael O. ; Sobel, Edward ; Strecker, Manfred
Metamorphic dome complexes occur within the internal structures of the northern Himalaya and southern Tibet. Their origin, deformation, and fault displacement patterns are poorly constrained. We report new field mapping, structural data, and cooling ages from the western flank of the Leo Pargil dome in the northwestern Himalaya in an attempt to characterize its post-middle Miocene structural development. The western flank of the dome is characterized by shallow, west-dipping pervasive foliation and WNW-ESE mineral lineation. Shear-sense indicators demonstrate that it is affected by east-west normal faulting that facilitated exhumation of high-grade metamorphic rocks in a contractional setting. Sustained top-to-northwest normal faulting during exhumation is observed in a progressive transition from ductile to brittle deformation. Garnet and kyanite indicate that the Leo Pargil dome was exhumed from the mid-crust. Ar- 40/Ar-39 mica and apatite fission track (AFT) ages constrain cooling and exhumation pathways front 350 to 60 degrees C and suggest that the dome cooled in three stages since the middle Miocene. Ar-40/Ar-39 white mica ages of 16-14 Ma suggest a first phase of rapid cooling and provide minimum estimates for the onset of dome exhumation. AFT ages between 10 and 8 Ma suggest that ductile fault displacement had ceased by then, and AFT track-length data from high-elevation samples indicate that the rate of cooling had decreased significantly. We interpret this to indicate decreased fault displacement along the Leo Pargil shear zone and possibly a transition to the Kaurik-Chango normal fault system between 10 and 6 Ma. AFT ages from lower elevations indicate accelerated cooling since the Pliocene that cannot be related to pure fault displacement, and therefore may reflect more pronounced regionally distributed and erosion-driven exhumation
Thiede, Rasmus Christoph ; Arrowsmith, J. Ramón ; Bookhagen, Bodo ; McWilliams, Michael O. ; Sobel, Edward ; Strecker, Manfred
Whether variations in the spatial distribution of erosion influence the location, style, and magnitude of deformation within the Himalayan orogen is a matter of debate. We report new Ar-40/Ar-39 white mica and apatite fission- track (AFT) ages that measure the vertical component of exhumation rates along an similar to 120-km-wide NE-SW transect spanning the greater Sutlej region of northwest India. The Ar-40/Ar-39 data indicate that first the High Himalayan Crystalline units cooled below their closing temperature during the early to middle Miocene. Subsequently, Lesser Himalayan Crystalline nappes cooled rapidly, indicating southward propagation of the orogen during late Miocene to Pliocene time. The AFT data, in contrast, imply synchronous exhumation of a NE-SW-oriented similar to 80 x 40 km region spanning both crystalline nappes during the Pliocene-Quaternary. The locus of pronounced exhumation defined by the AFT data correlates with a region of high precipitation, discharge, and sediment flux rates during the Holocene. This correlation suggests that although tectonic processes exerted the dominant control on the denudation pattern before and until the middle Miocene; erosion may have been the most important factor since the Pliocene
tAliu, E. ; Archambault, S. ; Arlen, T. ; Aune, T. ; Beilicke, M. ; Benbow, W. ; Bird, R. ; Bouvier, A. ; Bradbury, S. M. ; Buckley, J. H. ; Bugaev, V. ; Byrum, K. ; Cannon, A. ; Cesarini, A. ; Ciupik, L. ; Collins-Hughes, E. ; Connolly, M. P. ; Cui, W. ; Dickherber, R. ; Duke, C. ; Dumm, J. ; Dwarkadas, Vikram V. ; Errando, M. ; Falcone, A. ; Federici, Simone ; Feng, Q. ; Finley, J. P. ; Finnegan, G. ; Fortson, L. ; Furniss, A. ; Galante, N. ; Gall, D. ; Gillanders, G. H. ; Godambe, S. ; Gotthelf, E. V. ; Griffin, S. ; Grube, J. ; Gyuk, G. ; Hanna, D. ; Holder, J. ; Huan, H. ; Hughes, G. ; Humensky, T. B. ; Kaaret, P. ; Karlsson, N. ; Kertzman, M. ; Khassen, Y. ; Kieda, D. ; Krawczynski, H. ; Krennrich, F. ; Lang, M. J. ; Lee, K. ; Madhavan, A. S. ; Maier, G. ; Majumdar, P. ; McArthur, S. ; McCann, A. ; Millis, J. ; Moriarty, P. ; Mukherjee, R. ; Nelson, T. ; de Bhroithe, A. O'Faolain ; Ong, R. A. ; Orr, M. ; Otte, A. N. ; Pandel, D. ; Park, N. ; Perkins, J. S. ; Pohl, Martin ; Popkow, A. ; Prokoph, H. ; Quinn, J. ; Ragan, K. ; Reyes, L. C. ; Reynolds, P. T. ; Roache, E. ; Rose, H. J. ; Ruppel, Jens ; Saxon, D. B. ; Schroedter, M. ; Sembroski, G. H. ; Sentuerk, G. D. ; Skole, C. ; Telezhinsky, Igor O. ; Tesic, G. ; Theiling, M. ; Thibadeau, S. ; Tsurusaki, K. ; Tyler, J. ; Varlotta, A. ; Vassiliev, V. V. ; Vincent, S. ; Wakely, S. P. ; Ward, J. E. ; Weekes, T. C. ; Weinstein, A. ; Weisgarber, T. ; Welsing, R. ; Williams, D. A. ; Zitzer, B.
We report the discovery of an unidentified, extended source of very-high-energy gamma-ray emission, VER J2019+407, within the radio shell of the supernova remnant SNR G78.2+2.1, using 21.4 hr of data taken by the VERITAS gamma-ray observatory in 2009. These data confirm the preliminary indications of gamma-ray emission previously seen in a two-year (2007-2009) blind survey of the Cygnus region by VERITAS. VER J2019+407, which is detected at a post-trials significance of 7.5 standard deviations in the 2009 data, is localized to the northwestern rim of the remnant in a region of enhanced radio and X-ray emission. It has an intrinsic extent of 0 degrees.23 +/- 0 degrees.03(stat-0 degrees.02sys)(+0 degrees.04) and its spectrum is well-characterized by a differential power law (dN/dE = N-0 x (E/TeV)-Gamma) with a photon index of Gamma = 2.37 +/- 0.14(stat) +/- 0.20(sys) and a flux normalization of N-0 = 1.5 +/- 0.2(stat) +/- 0.4(sys) x 10(-12) photon TeV-1 cm(-2) s(-1). This yields an integral flux of 5.2 +/- 0.8(stat) +/- 1.4(sys) x 10(-12) photon cm(-2) s(-1) above 320 GeV, corresponding to 3.7% of the Crab Nebula flux. We consider the relationship of the TeV gamma-ray emission with the GeV gamma-ray emission seen from SNR G78.2+2.1 as well as that seen from a nearby cocoon of freshly accelerated cosmic rays. Multiple scenarios are considered as possible origins for the TeV gamma-ray emission, including hadronic particle acceleration at the SNR shock.
Sandee, A. J. ; Williams, Charlotte K. ; Evans, N. R. ; Davies, J. E. ; Boothby, C. E. ; Köhler, Anna ; Friend, Richard H. ; Holmes, Andrew B.
Sackett, Penny D. ; Albrow, Michael D. ; Beaulieu, Jean-Philippe ; Caldwell, John A. R. ; Coutures, C. ; Dominik, M. ; Greenhill, John ; Hill, K. ; Horne, Keith ; Jorgensen, Uffe Grae ; Kane, Stephen R. ; Kubas, Daniel ; Martin, Ralph ; Menzies, J. W. ; Pollard, K. R. ; Sahu, K. C. ; Wambsganß, Joachim ; Watson, R. ; Williams, A.
Due to their extremely small luminosity compared to the stars they orbit, planets outside our own Solar System are extraordinarily difficult to detect directly in optical light. Careful photometric monitoring of distant stars, however, can reveal the presence of exoplanets via the microlensing or eclipsing effects they induce. The international PLANET collaboration is performing such monitoring using a cadre of semi-dedicated telescopes around the world. Their results constrain the number of gas giants orbiting 1-7 AU from the most typical stars in the Galaxy. Upgrades in the program are opening regions of ''exoplanet discovery space'' - toward smaller masses and larger orbital radii - that are inaccessible to the Doppler velocity technique.
Richardson, Noel D. ; Shenar, Tomer ; Roy-Loubier, Olivier ; Schaefer, Gail ; Moffat, Anthony F. J. ; St-Louis, Nicole ; Gies, Douglas R. ; Farrington, Chris ; Hill, Grant M. ; Williams, Peredur M. ; Gordon, Kathryn ; Pablo, Herbert ; Ramiaramanantsoa, Tahina
We report on interferometric observations with the CHARAArray of two classical Wolf-Rayet (WR) stars in suspected binary systems, namely WR 137 and WR 138. In both cases, we resolve the component stars to be separated by a few milliarcseconds. The data were collected in the H band, and provide a measure of the fractional flux for both stars in each system. We find that the WR star is the dominant H-band light source in both systems (fWR, 137 = 0.59 +/- 0.04; fWR, 138 = 0.67 +/- 0.01), which is confirmed through both comparisons with estimated fundamental parameters for WR stars and O dwarfs, as well as through spectral modelling of each system. Our spectral modelling also provides fundamental parameters for the stars and winds in these systems. The results on WR 138 provide evidence that it is a binary system which may have gone through a previous mass-transfer episode to create the WR star. The separation and position of the stars in the WR 137 system together with previous results from the IOTA interferometer provides evidence that the binary is seen nearly edgeon. The possible edge-on orbit of WR 137 aligns well with the dust production site imaged by the Hubble Space Telescope during a previous periastron passage, showing that the dust production may be concentrated in the orbital plane.
Read, Betsy A. ; Kegel, Jessica ; Klute, Mary J. ; Kuo, Alan ; Lefebvre, Stephane C. ; Maumus, Florian ; Mayer, Christoph ; Miller, John ; Monier, Adam ; Salamov, Asaf ; Young, Jeremy ; Aguilar, Maria ; Claverie, Jean-Michel ; Frickenhaus, Stephan ; Gonzalez, Karina ; Herman, Emily K. ; Lin, Yao-Cheng ; Napier, Johnathan ; Ogata, Hiroyuki ; Sarno, Analissa F. ; Shmutz, Jeremy ; Schroeder, Declan ; de Vargas, Colomban ; Verret, Frederic ; von Dassow, Peter ; Valentin, Klaus ; Van de Peer, Yves ; Wheeler, Glen ; Dacks, Joel B. ; Delwiche, Charles F. ; Dyhrman, Sonya T. ; Glöckner, Gernot ; John, Uwe ; Richards, Thomas ; Worden, Alexandra Z. ; Zhang, Xiaoyu ; Grigoriev, Igor V. ; Allen, Andrew E. ; Bidle, Kay ; Borodovsky, M. ; Bowler, C. ; Brownlee, Colin ; Cock, J. Mark ; Elias, Marek ; Gladyshev, Vadim N. ; Groth, Marco ; Guda, Chittibabu ; Hadaegh, Ahmad ; Iglesias-Rodriguez, Maria Debora ; Jenkins, J. ; Jones, Bethan M. ; Lawson, Tracy ; Leese, Florian ; Lindquist, Erika ; Lobanov, Alexei ; Lomsadze, Alexandre ; Malik, Shehre-Banoo ; Marsh, Mary E. ; Mackinder, Luke ; Mock, Thomas ; Müller-Röber, Bernd ; Pagarete, Antonio ; Parker, Micaela ; Probert, Ian ; Quesneville, Hadi ; Raines, Christine ; Rensing, Stefan A. ; Riano-Pachon, Diego Mauricio ; Richier, Sophie ; Rokitta, Sebastian ; Shiraiwa, Yoshihiro ; Soanes, Darren M. ; van der Giezen, Mark ; Wahlund, Thomas M. ; Williams, Bryony ; Wilson, Willie ; Wolfe, Gordon ; Wurch, Louie L.
Coccolithophores have influenced the global climate for over 200 million years(1). These marine phytoplankton can account for 20 per cent of total carbon fixation in some systems(2). They form blooms that can occupy hundreds of thousands of square kilometres and are distinguished by their elegantly sculpted calcium carbonate exoskeletons (coccoliths), rendering them visible from space(3). Although coccolithophores export carbon in the form of organic matter and calcite to the sea floor, they also release CO2 in the calcification process. Hence, they have a complex influence on the carbon cycle, driving either CO2 production or uptake, sequestration and export to the deep ocean(4). Here we report the first haptophyte reference genome, from the coccolithophore Emiliania huxleyi strain CCMP1516, and sequences from 13 additional isolates. Our analyses reveal a pan genome (core genes plus genes distributed variably between strains) probably supported by an atypical complement of repetitive sequence in the genome. Comparisons across strains demonstrate that E. huxleyi, which has long been considered a single species, harbours extensive genome variability reflected in different metabolic repertoires. Genome variability within this species complex seems to underpin its capacity both to thrive in habitats ranging from the equator to the subarctic and to form large-scale episodic blooms under a wide variety of environmental conditions.
Orienti, M. ; Finke, J. ; Raiteri, C. M. ; Hovatta, T. ; Larsson, J. ; Max-Moerbeck, W. ; Perkins, J. ; Readhead, A. C. S. ; Richards, J. L. ; Beilicke, M. ; Benbow, W. ; Berger, K. ; Bird, R. ; Bugaev, V. ; Cardenzana, J. V. ; Cerruti, M. ; Chen, Xuhui ; Ciupik, L. ; Dickinson, H. J. ; Eisch, J. D. ; Errando, M. ; Falcone, A. ; Finley, J. P. ; Fleischhack, H. ; Fortin, P. ; Fortson, L. ; Furniss, A. ; Gerard, L. ; Gillanders, G. H. ; Griffiths, S. T. ; Grube, J. ; Gyuk, G. ; Hakansson, Nils ; Holder, J. ; Humensky, T. B. ; Kar, P. ; Kertzman, M. ; Khassen, Y. ; Kieda, D. ; Krennrich, F. ; Kumar, S. ; Lang, M. J. ; Maier, G. ; McCann, A. ; Meagher, K. ; Moriarty, P. ; Mukherjee, R. ; Nieto, D. ; Ong, R. A. ; Otte, A. N. ; Pohl, Manuela ; Popkow, A. ; Prokoph, H. ; Pueschel, Elisa ; Quinn, J. ; Ragan, K. ; Reynolds, P. T. ; Richards, G. T. ; Roache, E. ; Rousselle, J. ; Santander, M. ; Sembroski, G. H. ; Smith, A. W. ; Staszak, D. ; Telezhinsky, Igor O. ; Tucci, J. V. ; Tyler, J. ; Varlotta, A. ; Vassiliev, V. V. ; Wakely, S. P. ; Weinstein, A. ; Welsing, R. ; Williams, D. A. ; Zitzer, B.
We report on multifrequency observations performed during 2012 December-2013 August of the first narrow-line Seyfert 1 galaxy detected in gamma-rays, PMN J0948+0022 (z = 0.5846). A y -ray flare was observed by the Large Area Telescope on board Fermi during 2012 December-2013 January, reaching a daily peak flux in the 0.1-100 GeV energy range of (155 31) x 10 8 ph cm(-2) S-1 on 2013 January 1, corresponding to an apparent isotropic luminosity of similar to 1.5 x 1048 erg s(-1). The y -ray flaring period triggered Swift and Very Energetic Radiation Imaging Telescope Array System (VERITAS) observations in addition to radio and optical monitoring by Owens Valley Radio Observatory, Monitoring Of Jets in Active galactic nuclei with VLBA Experiments, and Catalina Real-time Transient Survey. A strong flare was observed in optical, UV, and X-rays on 2012 December 30, quasi-simultaneously to the y -ray flare, reaching a record flux for this source from optical to y gamma-rays. VERITAS observations at very high energy (E > 100 GeV) during 2013 January 6-17 resulted in an upper limit of F>0.2 Trev < 4.0 x 10(-12) ph cm(-2) s(-1). We compared the spectral energy distribution (SED) of the flaring state in 2013 January with that of an intermediate state observed in 2011. The two SEDs, modelled as synchrotron emission and an external Compton scattering of seed photons from a dust torus, can be modelled by changing both the electron distribution parameters and the magnetic field.
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia
(2019)
Middeldorp, Christel M. ; Mahajan, Anubha ; Horikoshi, Momoko ; Robertson, Neil R. ; Beaumont, Robin N. ; Bradfield, Jonathan P. ; Bustamante, Mariona ; Cousminer, Diana L. ; Day, Felix R. ; De Silva, N. Maneka ; Guxens, Monica ; Mook-Kanamori, Dennis O. ; St Pourcain, Beate ; Warrington, Nicole M. ; Adair, Linda S. ; Ahlqvist, Emma ; Ahluwalia, Tarunveer Singh ; Almgren, Peter ; Ang, Wei ; Atalay, Mustafa ; Auvinen, Juha ; Bartels, Meike ; Beckmann, Jacques S. ; Bilbao, Jose Ramon ; Bond, Tom ; Borja, Judith B. ; Cavadino, Alana ; Charoen, Pimphen ; Chen, Zhanghua ; Coin, Lachlan ; Cooper, Cyrus ; Curtin, John A. ; Custovic, Adnan ; Das, Shikta ; Davies, Gareth E. ; Dedoussis, George V. ; Duijts, Liesbeth ; Eastwood, Peter R. ; Eliasen, Anders U. ; Elliott, Paul ; Eriksson, Johan G. ; Estivill, Xavier ; Fadista, Joao ; Fedko, Iryna O. ; Frayling, Timothy M. ; Gaillard, Romy ; Gauderman, W. James ; Geller, Frank ; Gilliland, Frank ; Gilsanz, Vincente ; Granell, Raquel ; Grarup, Niels ; Groop, Leif ; Hadley, Dexter ; Hakonarson, Hakon ; Hansen, Torben ; Hartman, Catharina A. ; Hattersley, Andrew T. ; Hayes, M. Geoffrey ; Hebebrand, Johannes ; Heinrich, Joachim ; Helgeland, Oyvind ; Henders, Anjali K. ; Henderson, John ; Henriksen, Tine B. ; Hirschhorn, Joel N. ; Hivert, Marie-France ; Hocher, Berthold ; Holloway, John W. ; Holt, Patrick ; Hottenga, Jouke-Jan ; Hypponen, Elina ; Iniguez, Carmen ; Johansson, Stefan ; Jugessur, Astanand ; Kahonen, Mika ; Kalkwarf, Heidi J. ; Kaprio, Jaakko ; Karhunen, Ville ; Kemp, John P. ; Kerkhof, Marjan ; Koppelman, Gerard H. ; Korner, Antje ; Kotecha, Sailesh ; Kreiner-Moller, Eskil ; Kulohoma, Benard ; Kumar, Ashish ; Kutalik, Zoltan ; Lahti, Jari ; Lappe, Joan M. ; Larsson, Henrik ; Lehtimaki, Terho ; Lewin, Alexandra M. ; Li, Jin ; Lichtenstein, Paul ; Lindgren, Cecilia M. ; Lindi, Virpi ; Linneberg, Allan ; Liu, Xueping ; Liu, Jun ; Lowe, William L. ; Lundstrom, Sebastian ; Lyytikainen, Leo-Pekka ; Ma, Ronald C. W. ; Mace, Aurelien ; Magi, Reedik ; Magnus, Per ; Mamun, Abdullah A. ; Mannikko, Minna ; Martin, Nicholas G. ; Mbarek, Hamdi ; McCarthy, Nina S. ; Medland, Sarah E. ; Melbye, Mads ; Melen, Erik ; Mohlke, Karen L. ; Monnereau, Claire ; Morgen, Camilla S. ; Morris, Andrew P. ; Murray, Jeffrey C. ; Myhre, Ronny ; Najman, Jackob M. ; Nivard, Michel G. ; Nohr, Ellen A. ; Nolte, Ilja M. ; Ntalla, Ioanna ; Oberfield, Sharon E. ; Oken, Emily ; Oldehinkel, Albertine J. ; Pahkala, Katja ; Palviainen, Teemu ; Panoutsopoulou, Kalliope ; Pedersen, Oluf ; Pennell, Craig E. ; Pershagen, Goran ; Pitkanen, Niina ; Plomin, Robert ; Power, Christine ; Prasad, Rashmi B. ; Prokopenko, Inga ; Pulkkinen, Lea ; Raikkonen, Katri ; Raitakari, Olli T. ; Reynolds, Rebecca M. ; Richmond, Rebecca C. ; Rivadeneira, Fernando ; Rodriguez, Alina ; Rose, Richard J. ; Salem, Rany ; Santa-Marina, Loreto ; Saw, Seang-Mei ; Schnurr, Theresia M. ; Scott, James G. ; Selzam, Saskia ; Shepherd, John A. ; Simpson, Angela ; Skotte, Line ; Sleiman, Patrick M. A. ; Snieder, Harold ; Sorensen, Thorkild I. A. ; Standl, Marie ; Steegers, Eric A. P. ; Strachan, David P. ; Straker, Leon ; Strandberg, Timo ; Taylor, Michelle ; Teo, Yik-Ying ; Thiering, Elisabeth ; Torrent, Maties ; Tyrrell, Jessica ; Uitterlinden, Andre G. ; van Beijsterveldt, Toos ; van der Most, Peter J. ; van Duijn, Cornelia M. ; Viikari, Jorma ; Vilor-Tejedor, Natalia ; Vogelezang, Suzanne ; Vonk, Judith M. ; Vrijkotte, Tanja G. M. ; Vuoksimaa, Eero ; Wang, Carol A. ; Watkins, William J. ; Wichmann, H-Erich ; Willemsen, Gonneke ; Williams, Gail M. ; Wilson, James F. ; Wray, Naomi R. ; Xu, Shujing ; Xu, Cheng-Jian ; Yaghootkar, Hanieh ; Yi, Lu ; Zafarmand, Mohammad Hadi ; Zeggini, Eleftheria ; Zemel, Babette S. ; Hinney, Anke ; Lakka, Timo A. ; Whitehouse, Andrew J. O. ; Sunyer, Jordi ; Widen, Elisabeth E. ; Feenstra, Bjarke ; Sebert, Sylvain ; Jacobsson, Bo ; Njolstad, Pal R. ; Stoltenberg, Camilla ; Smith, George Davey ; Lawlor, Debbie A. ; Paternoster, Lavinia ; Timpson, Nicholas J. ; Ong, Ken K. ; Bisgaard, Hans ; Bonnelykke, Klaus ; Jaddoe, Vincent W. V. ; Tiemeier, Henning ; Jarvelin, Marjo-Riitta ; Evans, David M. ; Perry, John R. B. ; Grant, Struan F. A. ; Boomsma, Dorret I. ; Freathy, Rachel M. ; McCarthy, Mark I. ; Felix, Janine F.
The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.
Maddock, Simon T. ; Childerstone, Aaron ; Fry, Bryan Grieg ; Williams, David J. ; Barlow, Axel ; Wuester, Wolfgang
Genetic analyses of Australasian organisms have resulted in the identification of extensive cryptic diversity across the continent. The venomous elapid snakes are among the best-studied organismal groups in this region, but many knowledge gaps persist: for instance, despite their iconic status, the species-level diversity among Australo-Papuan blacksnakes (Pseudechis) has remained poorly understood due to the existence of a group of cryptic species within the P. australis species complex, collectively termed "pygmy mulga snakes". Using two mitochondrial and three nuclear loci we assess species boundaries within the genus using Bayesian species delimitation methods and reconstruct their phylogenetic history using multispecies coalescent approaches. Our analyses support the recognition of 10 species, including all of the currently described pygmy mulga snakes and one undescribed species from the Northern Territory of Australia. Phylogenetic relationships within the genus are broadly consistent with previous work, with the recognition of three major groups, the viviparous red-bellied black snake P. porphyriacus forming the sister species to two clades consisting of ovoviviparous species.
Lützow, Karola ; Hommes-Schattmann, Paul J. ; Neffe, Axel T. ; Ahmad, Bilal ; Williams, Gareth R. ; Lendlein, Andreas
Strategies to surface-functionalize scaffolds by covalent binding of biologically active compounds are of fundamental interest to control the interactions between scaffolds and biomolecules or cells. Poly(para-dioxanone) (PPDO) is a clinically established polymer that has shown potential as temporary implant, eg, for the reconstruction of the inferior vena cava, as a nonwoven fiber mesh. However, PPDO lacks suitable chemical groups for covalent functionalization. Furthermore, PPDO is highly sensitive to hydrolysis, reflected by short in vivo half-life times and degradation during storage. Establishing a method for covalent functionalization without degradation of this hydrolyzable polymer is therefore important to enable the surface tailoring for tissue engineering applications. It was hypothesized that treatment of PPDO with an N-hydroxysuccinimide ester group bearing perfluorophenyl azide (PFPA) under UV irradiation would allow efficient surface functionalization of the scaffold. X-ray photoelectron spectroscopy and attenuated total reflectance Fourier-transformed infrared spectroscopy investigation revealed the successful binding, while a gel permeation chromatography study showed that degradation did not occur under these conditions. Coupling of a rhodamine dye to the N-hydroxysuccinimide esters on the surface of a PFPA-functionalized scaffold via its amine linker showed a homogenous staining of the PPDO in laser confocal microscopy. The PFPA method is therefore applicable even to the surface functionalization of hydrolytically labile polymers, and it was demonstrated that PFPA chemistry may serve as a versatile tool for the (bio-)functionalization of PPDO scaffolds.
Kubas, Daniel ; Cassan, A. ; Beaulieu, Jean-Philippe ; Coutures, C. ; Dominik, M. ; Albrow, Michael D. ; Brillant, Stephane ; Caldwell, John A. R. ; Dominis, Dijana ; Donatowicz, J. ; Fendt, Christian ; Fouque, P. ; Jorgensen, Uffe Grae ; Greenhill, John ; Hill, K. ; Heinmüller, Janine ; Horne, Keith ; Kane, Stephen R. ; Marquette, Jean-Baptiste ; Martin, Ralph ; Menzies, J. W. ; Pollard, K. R. ; Sahu, K. C. ; Vinter, C. ; Wambsganss, Joachim ; Watson, R. ; Williams, A. ; Thurl, C.
We analyze the photometric data obtained by PLANET and OGLE on the caustic-crossing binary-lens microlensing event OGLE-2002-BLG-069. Thanks to the excellent photometric and spectroscopic coverage of the event, we are able to constrain the lens model up to the known ambiguity between close and wide binary lenses. The detection of annual parallax in combination with measurements of extended-source effects allows us to determine the mass, distance and velocity of the lens components for the competing models. While the model involving a close binary lens leads to a Bulge- Disc lens scenario with a lens mass of M = (0.51 ± 0.15) M-&ODOT; and distance of D-L = (2.9 ± 0.4) kpc, the wide binary lens solution requires a rather implausible binary black-hole lens ( M &GSIM; 126 M-&ODOT;). Furthermore we compare current state-of-the-art numerical and empirical models for the surface brightness profile of the source, a G5III Bulge giant. We find that a linear limb-darkening model for the atmosphere of the source star is consistent with the data whereas a PHOENIX atmosphere model assuming LTE and with no free parameter does not match our observations
Khider, D. ; Emile-Geay, J. ; McKay, N. P. ; Gil, Y. ; Garijo, D. ; Ratnakar, V ; Alonso-Garcia, M. ; Bertrand, S. ; Bothe, O. ; Brewer, P. ; Bunn, A. ; Chevalier, M. ; Comas-Bru, L. ; Csank, A. ; Dassie, E. ; DeLong, K. ; Felis, T. ; Francus, P. ; Frappier, A. ; Gray, W. ; Goring, S. ; Jonkers, L. ; Kahle, M. ; Kaufman, D. ; Kehrwald, N. M. ; Martrat, B. ; McGregor, H. ; Richey, J. ; Schmittner, A. ; Scroxton, N. ; Sutherland, E. ; Thirumalai, Kaustubh ; Allen, K. ; Arnaud, F. ; Axford, Y. ; Barrows, T. ; Bazin, L. ; Birch, S. E. Pilaar ; Bradley, E. ; Bregy, J. ; Capron, E. ; Cartapanis, O. ; Chiang, H-W ; Cobb, K. M. ; Debret, M. ; Dommain, Réne ; Du, J. ; Dyez, K. ; Emerick, S. ; Erb, M. P. ; Falster, G. ; Finsinger, W. ; Fortier, D. ; Gauthier, Nicolas ; George, S. ; Grimm, E. ; Hertzberg, J. ; Hibbert, F. ; Hillman, A. ; Hobbs, W. ; Huber, M. ; Hughes, A. L. C. ; Jaccard, S. ; Ruan, J. ; Kienast, M. ; Konecky, B. ; Le Roux, G. ; Lyubchich, V ; Novello, V. F. ; Olaka, L. ; Partin, J. W. ; Pearce, C. ; Phipps, S. J. ; Pignol, C. ; Piotrowska, N. ; Poli, M-S ; Prokopenko, A. ; Schwanck, F. ; Stepanek, C. ; Swann, G. E. A. ; Telford, R. ; Thomas, E. ; Thomas, Z. ; Truebe, S. ; von Gunten, L. ; Waite, A. ; Weitzel, N. ; Wilhelm, B. ; Williams, J. ; Winstrup, M. ; Zhao, N. ; Zhou, Y.
The progress of science is tied to the standardization of measurements, instruments, and data. This is especially true in the Big Data age, where analyzing large data volumes critically hinges on the data being standardized. Accordingly, the lack of community-sanctioned data standards in paleoclimatology has largely precluded the benefits of Big Data advances in the field. Building upon recent efforts to standardize the format and terminology of paleoclimate data, this article describes the Paleoclimate Community reporTing Standard (PaCTS), a crowdsourced reporting standard for such data. PaCTS captures which information should be included when reporting paleoclimate data, with the goal of maximizing the reuse value of paleoclimate data sets, particularly for synthesis work and comparison to climate model simulations. Initiated by the LinkedEarth project, the process to elicit a reporting standard involved an international workshop in 2016, various forms of digital community engagement over the next few years, and grassroots working groups. Participants in this process identified important properties across paleoclimate archives, in addition to the reporting of uncertainties and chronologies; they also identified archive-specific properties and distinguished reporting standards for new versus legacy data sets. This work shows that at least 135 respondents overwhelmingly support a drastic increase in the amount of metadata accompanying paleoclimate data sets. Since such goals are at odds with present practices, we discuss a transparent path toward implementing or revising these recommendations in the near future, using both bottom-up and top-down approaches.
Kefi, Sonia ; Berlow, Eric L. ; Wieters, Evie A. ; Navarrete, Sergio A. ; Petchey, Owen L. ; Wood, Spencer A. ; Boit, Alice ; Joppa, Lucas N. ; Lafferty, Kevin D. ; Williams, Richard J. ; Martinez, Neo D. ; Menge, Bruce A. ; Blanchette, Carol A. ; Iles, Alison C. ; Brose, Ulrich
Organisms eating each other are only one of many types of well documented and important interactions among species. Other such types include habitat modification, predator interference and facilitation. However, ecological network research has been typically limited to either pure food webs or to networks of only a few (<3) interaction types. The great diversity of non-trophic interactions observed in nature has been poorly addressed by ecologists and largely excluded from network theory. Herein, we propose a conceptual framework that organises this diversity into three main functional classes defined by how they modify specific parameters in a dynamic food web model. This approach provides a path forward for incorporating non-trophic interactions in traditional food web models and offers a new perspective on tackling ecological complexity that should stimulate both theoretical and empirical approaches to understanding the patterns and dynamics of diverse species interactions in nature.
Jiang, G. F. ; DePoy, D. L. ; Gal-Yam, A. ; Gaudi, B. S. ; Gould, A. ; Han, C. ; Lipkin, Y. ; Maoz, D. ; Ofek, E. O. ; Park, B. G. ; Pogge, R. W. ; Udalski, A. ; Kubiak, Marcin ; Szymanski, M. K. ; Szewczyk, O. ; Zerbrun, K. ; Wyrzykowski, L. ; Soszynski, I. ; Pietrzynski, G. ; Albrow, Michael D. ; Beaulieu, Jean-Philippe ; Caldwell, John A. R. ; Cassan, A. ; Coutures, C. ; Dominik, M. ; Donatowicz, J. ; Fouque, P. ; Greenhill, John ; Hill, K. ; Horne, Keith ; Jorgensen, S. F. ; Jorgensen, Uffe Grae ; Kane, Stephen R. ; Kubas, Daniel ; Martin, Ralph ; Menzies, J. W. ; Pollard, R. ; Sahu, K. C. ; Wambsganss, Joachim ; Watson, R. ; Williams, A.
Microlensing is the only known direct method to measure the masses of stars that lack visible companions. In terms of microlensing observables, the mass is given by M (c(2)/4G)(r) over tilde (E)theta(E) and so requires the measurement of both the angular Einstein radius theta(E) and the projected Einstein radius (r) over tilde (E). Simultaneous measurement of these two parameters is extremely rare. Here we analyze OGLE-2003-BLG-238, a spectacularly bright (I-min 10.3), high-magnification (A(max) 170) microlensing event. Pronounced finite-source effects permit a measurement of theta(E) = 650 muas. Although the timescale of the event is only t(E) 38 days, one can still obtain weak constraints on the microlens parallax: 4.4 AU < <(r)over tilde>(E) < 18 AU at the 1 σ level. Together these two parameter measurements yield a range for the lens mass of 0.36 M-&ODOT; < M < 1.48 M-&ODOT;. As was the case for MACHO- LMC-5, the only other single star (apart from the Sun) whose mass has been determined from its gravitational effects, this estimate is rather crude. It does, however, demonstrate the viability of the technique. We also discuss future prospects for single-lens mass measurements
Hommes-Schattmann, Paul J. ; Neffe, Axel T. ; Ahmad, Bilal ; Williams, Gareth R. ; Vanneaux, Valerie ; Menasche, Philippe ; Kalfa, David ; Lendlein, Andreas
The tissue integration of synthetic polymers can be promoted by displaying RGD peptides at the biointerface with the objective of enhancing colonization of the material by endogenous cells. A firm but flexible attachment of the peptide to the polymer matrix, still allowing interaction with receptors, is therefore of interest. Here, the covalent coupling of flexible physical anchor groups, allowing for temporary immobilization on polymeric surfaces via hydrophobic or dipole-dipole interactions, to a RGD peptide was investigated. For this purpose, a stearate or an oligo(ethylene glycol) (OEG) was attached to GRGDS in 51-69% yield. The obtained RGD linker constructs were characterized by NMR, IR and MALDI-ToF mass spectrometry, revealing that the commercially available OEG and stearate linkers are in fact mixtures of similar compounds. The RGD linker constructs were co-electrospun with poly(p-dioxanone) (PPDO). After electrospinning, nitrogen could be detected on the surface of the PPDO fibers by X-ray photoelectron spectroscopy. The nitrogen content exceeded the calculated value for the homogeneous material mixture suggesting a pronounced presentation of the peptide on the fiber surface. Increasing amounts of RGD linker constructs in the electrospinning solution did not lead to a detection of an increased amount of peptide on the scaffold surface, suggesting inhomogeneous distribution of the peptide on the PPDO fiber surface. Human adipose-derived stem cells cultured on the patches showed similar viability as when cultured on PPDO containing pristine RGD. The fully characterized RGD linker constructs could serve as valuable tools for the further development of tissue-integrating polymeric scaffolds. Copyright (c) 2016 John Wiley & Sons, Ltd.
Hoke, Gregory D. ; Garzione, Carmala N. ; Araneo, Diego C. ; Latorre, Claudio ; Strecker, Manfred ; Williams, Kendra J.
Stable isotope altimetry is a useful tool for estimating paleoelevation in sedimentary records. Yet questions remain regarding how source moisture, climate, and local topography can influence these estimates. Here we present stable isotope altimetry results on late Quaternary pedogenic carbonates of known elevation on both flanks of the Andean orogen at 33 degrees S. We measured delta O-18 values of pedogenic carbonates and river water samples from small drainages at regular elevation increments within the Rio Aconcagua (Chile) and Rio Mendoza (Argentina) catchments. The delta O-18 values of river waters correlate well with elevation and show similar isotopic gradients between the Chilean (-3.7 parts per thousand/km) and Argentine (-4.8 parts per thousand/km) sides of the range. Uncertainties associated with scatter in the river water data and assumptions about the temperature of carbonate formation indicate that elevation estimates have 1 sigma errors of 350-450 m. We estimate the isotopic composition of soil water from pedogenic carbonates on both sides of the range by assuming mean annual temperatures based the modern temperature lapse rate from meteorological station data. Combined, our data show that stable isotope altimetry produces reasonable estimates of modern elevation, with the majority of our samples (60%) within the 1 sigma uncertainties and 77% within 2 sigma.