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- Willingale, R. (1)
- Willis, Judith H. (1)
- Wilson, James F. (1)
- Wilson, Willie (1)
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- de Gouveia Dal Pino, E. M. (1)
- de Mello Neto, J. R. T. (1)
- de Naurois, M. (1)
- de Oliveira, Y. (1)
- de Ona Wilhelmi, E. (1)
- de Souza, V. (1)
- de Vargas, Colomban (1)
- de la Calle, I. (1)
- van Beijsterveldt, Toos (1)
- van Driel, W. (1)
- van Duijn, Cornelia M. (1)
- van Eldik, C. (1)
- van der Giezen, Mark (1)
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Language
- English (8)
Is part of the Bibliography
- yes (8)
Keywords
- Air showers (1)
- Cherenkov Telescopes (1)
- Childhood traits and disorders (1)
- Consortium (1)
- Genetics (1)
- Gondwana (1)
- Longitudinal (1)
- Plate tectonics (1)
- Rodinia (1)
- Supercontinent breakup (1)
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia
(2019)
Middeldorp, Christel M. ; Mahajan, Anubha ; Horikoshi, Momoko ; Robertson, Neil R. ; Beaumont, Robin N. ; Bradfield, Jonathan P. ; Bustamante, Mariona ; Cousminer, Diana L. ; Day, Felix R. ; De Silva, N. Maneka ; Guxens, Monica ; Mook-Kanamori, Dennis O. ; St Pourcain, Beate ; Warrington, Nicole M. ; Adair, Linda S. ; Ahlqvist, Emma ; Ahluwalia, Tarunveer Singh ; Almgren, Peter ; Ang, Wei ; Atalay, Mustafa ; Auvinen, Juha ; Bartels, Meike ; Beckmann, Jacques S. ; Bilbao, Jose Ramon ; Bond, Tom ; Borja, Judith B. ; Cavadino, Alana ; Charoen, Pimphen ; Chen, Zhanghua ; Coin, Lachlan ; Cooper, Cyrus ; Curtin, John A. ; Custovic, Adnan ; Das, Shikta ; Davies, Gareth E. ; Dedoussis, George V. ; Duijts, Liesbeth ; Eastwood, Peter R. ; Eliasen, Anders U. ; Elliott, Paul ; Eriksson, Johan G. ; Estivill, Xavier ; Fadista, Joao ; Fedko, Iryna O. ; Frayling, Timothy M. ; Gaillard, Romy ; Gauderman, W. James ; Geller, Frank ; Gilliland, Frank ; Gilsanz, Vincente ; Granell, Raquel ; Grarup, Niels ; Groop, Leif ; Hadley, Dexter ; Hakonarson, Hakon ; Hansen, Torben ; Hartman, Catharina A. ; Hattersley, Andrew T. ; Hayes, M. Geoffrey ; Hebebrand, Johannes ; Heinrich, Joachim ; Helgeland, Oyvind ; Henders, Anjali K. ; Henderson, John ; Henriksen, Tine B. ; Hirschhorn, Joel N. ; Hivert, Marie-France ; Hocher, Berthold ; Holloway, John W. ; Holt, Patrick ; Hottenga, Jouke-Jan ; Hypponen, Elina ; Iniguez, Carmen ; Johansson, Stefan ; Jugessur, Astanand ; Kahonen, Mika ; Kalkwarf, Heidi J. ; Kaprio, Jaakko ; Karhunen, Ville ; Kemp, John P. ; Kerkhof, Marjan ; Koppelman, Gerard H. ; Korner, Antje ; Kotecha, Sailesh ; Kreiner-Moller, Eskil ; Kulohoma, Benard ; Kumar, Ashish ; Kutalik, Zoltan ; Lahti, Jari ; Lappe, Joan M. ; Larsson, Henrik ; Lehtimaki, Terho ; Lewin, Alexandra M. ; Li, Jin ; Lichtenstein, Paul ; Lindgren, Cecilia M. ; Lindi, Virpi ; Linneberg, Allan ; Liu, Xueping ; Liu, Jun ; Lowe, William L. ; Lundstrom, Sebastian ; Lyytikainen, Leo-Pekka ; Ma, Ronald C. W. ; Mace, Aurelien ; Magi, Reedik ; Magnus, Per ; Mamun, Abdullah A. ; Mannikko, Minna ; Martin, Nicholas G. ; Mbarek, Hamdi ; McCarthy, Nina S. ; Medland, Sarah E. ; Melbye, Mads ; Melen, Erik ; Mohlke, Karen L. ; Monnereau, Claire ; Morgen, Camilla S. ; Morris, Andrew P. ; Murray, Jeffrey C. ; Myhre, Ronny ; Najman, Jackob M. ; Nivard, Michel G. ; Nohr, Ellen A. ; Nolte, Ilja M. ; Ntalla, Ioanna ; Oberfield, Sharon E. ; Oken, Emily ; Oldehinkel, Albertine J. ; Pahkala, Katja ; Palviainen, Teemu ; Panoutsopoulou, Kalliope ; Pedersen, Oluf ; Pennell, Craig E. ; Pershagen, Goran ; Pitkanen, Niina ; Plomin, Robert ; Power, Christine ; Prasad, Rashmi B. ; Prokopenko, Inga ; Pulkkinen, Lea ; Raikkonen, Katri ; Raitakari, Olli T. ; Reynolds, Rebecca M. ; Richmond, Rebecca C. ; Rivadeneira, Fernando ; Rodriguez, Alina ; Rose, Richard J. ; Salem, Rany ; Santa-Marina, Loreto ; Saw, Seang-Mei ; Schnurr, Theresia M. ; Scott, James G. ; Selzam, Saskia ; Shepherd, John A. ; Simpson, Angela ; Skotte, Line ; Sleiman, Patrick M. A. ; Snieder, Harold ; Sorensen, Thorkild I. A. ; Standl, Marie ; Steegers, Eric A. P. ; Strachan, David P. ; Straker, Leon ; Strandberg, Timo ; Taylor, Michelle ; Teo, Yik-Ying ; Thiering, Elisabeth ; Torrent, Maties ; Tyrrell, Jessica ; Uitterlinden, Andre G. ; van Beijsterveldt, Toos ; van der Most, Peter J. ; van Duijn, Cornelia M. ; Viikari, Jorma ; Vilor-Tejedor, Natalia ; Vogelezang, Suzanne ; Vonk, Judith M. ; Vrijkotte, Tanja G. M. ; Vuoksimaa, Eero ; Wang, Carol A. ; Watkins, William J. ; Wichmann, H-Erich ; Willemsen, Gonneke ; Williams, Gail M. ; Wilson, James F. ; Wray, Naomi R. ; Xu, Shujing ; Xu, Cheng-Jian ; Yaghootkar, Hanieh ; Yi, Lu ; Zafarmand, Mohammad Hadi ; Zeggini, Eleftheria ; Zemel, Babette S. ; Hinney, Anke ; Lakka, Timo A. ; Whitehouse, Andrew J. O. ; Sunyer, Jordi ; Widen, Elisabeth E. ; Feenstra, Bjarke ; Sebert, Sylvain ; Jacobsson, Bo ; Njolstad, Pal R. ; Stoltenberg, Camilla ; Smith, George Davey ; Lawlor, Debbie A. ; Paternoster, Lavinia ; Timpson, Nicholas J. ; Ong, Ken K. ; Bisgaard, Hans ; Bonnelykke, Klaus ; Jaddoe, Vincent W. V. ; Tiemeier, Henning ; Jarvelin, Marjo-Riitta ; Evans, David M. ; Perry, John R. B. ; Grant, Struan F. A. ; Boomsma, Dorret I. ; Freathy, Rachel M. ; McCarthy, Mark I. ; Felix, Janine F.
The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.
Triplet energy back transfer in conjugated polymers with pendant phosphorescent iridium complexes
(2006)
Evans, Nicholas R. ; Devi, Lekshmi Sudha ; Mak, Chris S. K. ; Watkins, Scott E. ; Pascu, Sofia I. ; Köhler, Anna ; Friend, Richard H. ; Williams, Charlotte K. ; Holmes, Andrew B.
The nature of Dexter triplet energy transfer between bonded systems of a red phosphorescent iridium complex 13 and a conjugated polymer, polyfluorene, has been investigated in electrophosphorescent organic light-emitting diodes. Red- emitting phosphorescent iridium complexes based on the [Ir(btp)2(acac)]fragment (where btp is 2-(2 '- benzo[b]thienyl)pyridinato and acac is acetylacetonate) have been attached either directly (spacerless) or through a - (CH2)(8)-chain (octamethylene-tethered) at the 9-position of a 9-octylfluorene host. The resulting dibromo- functionalized spacerless (8) or octamethylene-tethered (12) fluorene monomers were chain extended by Suzuki polycondensations using the bis(boronate)-terminated fluorene macromonomers 16 in the presence of end-capping chlorobenzene solvent to produce the statistical spacerless (17) and octamethylene-tethered ( 18) copolymers containing an even dispersion of the pendant phosphorescent fragments. The spacerless monomer 12 adopts a face-to-face conformation with a separation of only 3.6 angstrom between the iridium complex and fluorenyl group, as shown by X-ray analysis of a single crystal, and this facilitates intramolecular triplet energy transfer in the spacerless copolymers 17. The photo- and electroluminescence efficiencies of the octamethylene-tethered copolymers 18 are double those of the spacerless copolymers 17, and this is consistent with suppression of the back transfer of triplets from the red phosphorescent iridium complex to the polyfluorene backbone in 18. The incorporation of a -(CH2)(8)- chain between the polymer host and phosphorescent guest is thus an important design principle for achieving higher efficiencies in those electrophosphorescent organic light-emitting diodes for which the triplet energy levels of the host and guest are similar
Sandee, A. J. ; Williams, Charlotte K. ; Evans, N. R. ; Davies, J. E. ; Boothby, C. E. ; Köhler, Anna ; Friend, Richard H. ; Holmes, Andrew B.
The extent of continental rifts and subduction zones through deep geological time provides insights into the mechanisms behind supercontinent cycles and the long term evolution of the mantle. However, previous compilations have stopped short of mapping the locations of rifts and subduction zones continuously since the Neoproterozoic and within a self-consistent plate kinematic framework. Using recently published plate models with continuously closing boundaries for the Neoproterozoic and Phanerozoic, we estimate how rift and peri-continental subduction length vary from 1 Ga to present and test hypotheses pertaining to the supercontinent cycle and supercontinent breakup. We extract measures of continental perimeter-to-area ratio as a proxy for the existence of a supercontinent, where during times of supercontinent existence the perimeter-to-area ratio should be low, and during assembly and dispersal it should be high. The amalgamation of Gondwana is clearly represented by changes in the length of peri-continental subduction and the breakup of Rodinia and Pangea by changes in rift lengths. The assembly of Pangea is not clearly defined using plate boundary lengths, likely because its formation resulted from the collision of only two large continents. Instead the assembly of Gondwana (ca. 520 Ma) marks the most prominent change in arc length and perimeter-to-area ratio during the last billion years suggesting that Gondwana during the Early Palaeozoic could explicitly be considered part of a Phanerozoic supercontinent. Consequently, the traditional understanding of the supercontinent cycle, in terms of supercontinent existence for short periods of time before dispersal and re-accretion, may be inadequate to fully describe the cycle. Instead, either a two-stage supercontinent cycle could be a more appropriate concept, or alternatively the time period of 1 to 0 Ga has to be considered as being dominated by supercontinent existence, with brief periods of dispersal and amalgamation.
Beaulieu, Jean-Philippe ; Bennett, David P. ; Fouqué, Pascal ; Williams, Andrew ; Dominik, Martin ; Jorgensen, Uffe Grae ; Kubas, Daniel ; Cassan, Arnaud ; Coutures, Christian ; Greenhill, John ; Hill, Kym ; Menzies, John ; Sackett, Penny D. ; Albrow, Michael D. ; Brillant, Stephane ; Caldwell, John A. R. ; Calitz, Johannes Jacobus ; Cook, Kem H. ; Corrales Cosmeli, Esperanza de Santa Cecilia ; Desort, Morgan ; Dieters, Stefan ; Dominis, Dijana ; Donatowicz, Jadzia ; Hoffman, Martie ; Kane, Stephen R. ; Marquette, Jean-Baptiste ; Martin, Ralph ; Meintjes, Pieter ; Pollard, Karen R. ; Sahu, Kailash C. ; Vinter, Christian ; Wambsganss, Joachim ; Woller, Kristian ; Horne, Keith ; Steele, Iain ; Bramich, Daniel M. ; Burgdorf, Martin ; Snodgrass, Colin ; Bode, Mike ; Udalski, Andr
In the favoured core-accretion model of formation of planetary systems, solid planetesimals accumulate to build up planetary cores, which then accrete nebular gas if they are sufficiently massive. Around M-dwarf stars ( the most common stars in our Galaxy), this model favours the formation of Earth-mass (M+) to Neptune-mass planets with orbital radii of 1 to 10 astronomical units (AU), which is consistent with the small number of gas giant planets known to orbit M-dwarf host stars(1-4). More than 170 extrasolar planets have been discovered with a wide range of masses and orbital periods, but planets of Neptune's mass or less have not hitherto been detected at separations of more than 0.15 AU from normal stars. Here we report the discovery of a 5.5(-2.7)(+5.5)M(+) planetary companion at a separation of 2.6(- 0.6)(+1.5) AU from a 0.22(-0.11)(+0.21)M(.) M-dwarf star, where M-. refers to a solar mass. (We propose to name it OGLE- 2005-BLG-390Lb, indicating a planetary mass companion to the lens star of the microlensing event.) The mass is lower than that of GJ876d (ref. 5), although the error bars overlap. Our detection suggests that such cool, sub-Neptune-mass planets may be more common than gas giant planets, as predicted by the core accretion theory.
Chipman, Ariel D. ; Ferrier, David E. K. ; Brena, Carlo ; Qu, Jiaxin ; Hughes, Daniel S. T. ; Schroeder, Reinhard ; Torres-Oliva, Montserrat ; Znassi, Nadia ; Jiang, Huaiyang ; Almeida, Francisca C. ; Alonso, Claudio R. ; Apostolou, Zivkos ; Aqrawi, Peshtewani ; Arthur, Wallace ; Barna, Jennifer C. J. ; Blankenburg, Kerstin P. ; Brites, Daniela ; Capella-Gutierrez, Salvador ; Coyle, Marcus ; Dearden, Peter K. ; Du Pasquier, Louis ; Duncan, Elizabeth J. ; Ebert, Dieter ; Eibner, Cornelius ; Erikson, Galina ; Evans, Peter D. ; Extavour, Cassandra G. ; Francisco, Liezl ; Gabaldon, Toni ; Gillis, William J. ; Goodwin-Horn, Elizabeth A. ; Green, Jack E. ; Griffiths-Jones, Sam ; Grimmelikhuijzen, Cornelis J. P. ; Gubbala, Sai ; Guigo, Roderic ; Han, Yi ; Hauser, Frank ; Havlak, Paul ; Hayden, Luke ; Helbing, Sophie ; Holder, Michael ; Hui, Jerome H. L. ; Hunn, Julia P. ; Hunnekuhl, Vera S. ; Jackson, LaRonda ; Javaid, Mehwish ; Jhangiani, Shalini N. ; Jiggins, Francis M. ; Jones, Tamsin E. ; Kaiser, Tobias S. ; Kalra, Divya ; Kenny, Nathan J. ; Korchina, Viktoriya ; Kovar, Christie L. ; Kraus, F. Bernhard ; Lapraz, Francois ; Lee, Sandra L. ; Lv, Jie ; Mandapat, Christigale ; Manning, Gerard ; Mariotti, Marco ; Mata, Robert ; Mathew, Tittu ; Neumann, Tobias ; Newsham, Irene ; Ngo, Dinh N. ; Ninova, Maria ; Okwuonu, Geoffrey ; Ongeri, Fiona ; Palmer, William J. ; Patil, Shobha ; Patraquim, Pedro ; Pham, Christopher ; Pu, Ling-Ling ; Putman, Nicholas H. ; Rabouille, Catherine ; Ramos, Olivia Mendivil ; Rhodes, Adelaide C. ; Robertson, Helen E. ; Robertson, Hugh M. ; Ronshaugen, Matthew ; Rozas, Julio ; Saada, Nehad ; Sanchez-Gracia, Alejandro ; Scherer, Steven E. ; Schurko, Andrew M. ; Siggens, Kenneth W. ; Simmons, DeNard ; Stief, Anna ; Stolle, Eckart ; Telford, Maximilian J. ; Tessmar-Raible, Kristin ; Thornton, Rebecca ; van der Zee, Maurijn ; von Haeseler, Arndt ; Williams, James M. ; Willis, Judith H. ; Wu, Yuanqing ; Zou, Xiaoyan ; Lawson, Daniel ; Muzny, Donna M. ; Worley, Kim C. ; Gibbs, Richard A. ; Akam, Michael ; Richards, Stephen
Myriapods (e. g., centipedes and millipedes) display a simple homonomous body plan relative to other arthropods. All members of the class are terrestrial, but they attained terrestriality independently of insects. Myriapoda is the only arthropod class not represented by a sequenced genome. We present an analysis of the genome of the centipede Strigamia maritima. It retains a compact genome that has undergone less gene loss and shuffling than previously sequenced arthropods, and many orthologues of genes conserved from the bilaterian ancestor that have been lost in insects. Our analysis locates many genes in conserved macro-synteny contexts, and many small-scale examples of gene clustering. We describe several examples where S. maritima shows different solutions from insects to similar problems. The insect olfactory receptor gene family is absent from S. maritima, and olfaction in air is likely effected by expansion of other receptor gene families. For some genes S. maritima has evolved paralogues to generate coding sequence diversity, where insects use alternate splicing. This is most striking for the Dscam gene, which in Drosophila generates more than 100,000 alternate splice forms, but in S. maritima is encoded by over 100 paralogues. We see an intriguing linkage between the absence of any known photosensory proteins in a blind organism and the additional absence of canonical circadian clock genes. The phylogenetic position of myriapods allows us to identify where in arthropod phylogeny several particular molecular mechanisms and traits emerged. For example, we conclude that juvenile hormone signalling evolved with the emergence of the exoskeleton in the arthropods and that RR-1 containing cuticle proteins evolved in the lineage leading to Mandibulata. We also identify when various gene expansions and losses occurred. The genome of S. maritima offers us a unique glimpse into the ancestral arthropod genome, while also displaying many adaptations to its specific life history.
Read, Betsy A. ; Kegel, Jessica ; Klute, Mary J. ; Kuo, Alan ; Lefebvre, Stephane C. ; Maumus, Florian ; Mayer, Christoph ; Miller, John ; Monier, Adam ; Salamov, Asaf ; Young, Jeremy ; Aguilar, Maria ; Claverie, Jean-Michel ; Frickenhaus, Stephan ; Gonzalez, Karina ; Herman, Emily K. ; Lin, Yao-Cheng ; Napier, Johnathan ; Ogata, Hiroyuki ; Sarno, Analissa F. ; Shmutz, Jeremy ; Schroeder, Declan ; de Vargas, Colomban ; Verret, Frederic ; von Dassow, Peter ; Valentin, Klaus ; Van de Peer, Yves ; Wheeler, Glen ; Dacks, Joel B. ; Delwiche, Charles F. ; Dyhrman, Sonya T. ; Glöckner, Gernot ; John, Uwe ; Richards, Thomas ; Worden, Alexandra Z. ; Zhang, Xiaoyu ; Grigoriev, Igor V. ; Allen, Andrew E. ; Bidle, Kay ; Borodovsky, M. ; Bowler, C. ; Brownlee, Colin ; Cock, J. Mark ; Elias, Marek ; Gladyshev, Vadim N. ; Groth, Marco ; Guda, Chittibabu ; Hadaegh, Ahmad ; Iglesias-Rodriguez, Maria Debora ; Jenkins, J. ; Jones, Bethan M. ; Lawson, Tracy ; Leese, Florian ; Lindquist, Erika ; Lobanov, Alexei ; Lomsadze, Alexandre ; Malik, Shehre-Banoo ; Marsh, Mary E. ; Mackinder, Luke ; Mock, Thomas ; Müller-Röber, Bernd ; Pagarete, Antonio ; Parker, Micaela ; Probert, Ian ; Quesneville, Hadi ; Raines, Christine ; Rensing, Stefan A. ; Riano-Pachon, Diego Mauricio ; Richier, Sophie ; Rokitta, Sebastian ; Shiraiwa, Yoshihiro ; Soanes, Darren M. ; van der Giezen, Mark ; Wahlund, Thomas M. ; Williams, Bryony ; Wilson, Willie ; Wolfe, Gordon ; Wurch, Louie L.
Coccolithophores have influenced the global climate for over 200 million years(1). These marine phytoplankton can account for 20 per cent of total carbon fixation in some systems(2). They form blooms that can occupy hundreds of thousands of square kilometres and are distinguished by their elegantly sculpted calcium carbonate exoskeletons (coccoliths), rendering them visible from space(3). Although coccolithophores export carbon in the form of organic matter and calcite to the sea floor, they also release CO2 in the calcification process. Hence, they have a complex influence on the carbon cycle, driving either CO2 production or uptake, sequestration and export to the deep ocean(4). Here we report the first haptophyte reference genome, from the coccolithophore Emiliania huxleyi strain CCMP1516, and sequences from 13 additional isolates. Our analyses reveal a pan genome (core genes plus genes distributed variably between strains) probably supported by an atypical complement of repetitive sequence in the genome. Comparisons across strains demonstrate that E. huxleyi, which has long been considered a single species, harbours extensive genome variability reflected in different metabolic repertoires. Genome variability within this species complex seems to underpin its capacity both to thrive in habitats ranging from the equator to the subarctic and to form large-scale episodic blooms under a wide variety of environmental conditions.
Introducing the CTA concept
(2013)
Acharya, B. S. ; Actis, M. ; Aghajani, T. ; Agnetta, G. ; Aguilar, J. ; Aharonian, Felix A. ; Ajello, M. ; Akhperjanian, A. G. ; Alcubierre, M. ; Aleksic, J. ; Alfaro, R. ; Aliu, E. ; Allafort, A. J. ; Allan, D. ; Allekotte, I. ; Amato, E. ; Anderson, J. ; Angüner, Ekrem Oǧuzhan ; Antonelli, L. A. ; Antoranz, P. ; Aravantinos, A. ; Arlen, T. ; Armstrong, T. ; Arnaldi, H. ; Arrabito, L. ; Asano, K. ; Ashton, T. ; Asorey, H. G. ; Awane, Y. ; Baba, H. ; Babic, A. ; Baby, N. ; Baehr, J. ; Bais, A. ; Baixeras, C. ; Bajtlik, S. ; Balbo, M. ; Balis, D. ; Balkowski, C. ; Bamba, A. ; Bandiera, R. ; Barber, A. ; Barbier, C. ; Barcelo, M. ; Barnacka, Anna ; Barnstedt, Jürgen ; Barres de Almeida, U. ; Barrio, J. A. ; Basili, A. ; Basso, S. ; Bastieri, D. ; Bauer, C. ; Baushev, Anton N. ; Becerra Gonzalez, J. ; Becherini, Yvonne ; Bechtol, K. C. ; Tjus, J. Becker ; Beckmann, Volker ; Bednarek, W. ; Behera, B. ; Belluso, M. ; Benbow, W. ; Berdugo, J. ; Berger, K. ; Bernard, F. ; Bernardino, T. ; Bernlöhr, K. ; Bhat, N. ; Bhattacharyya, S. ; Bigongiari, C. ; Biland, A. ; Billotta, S. ; Bird, T. ; Birsin, E. ; Bissaldi, E. ; Biteau, Jonathan ; Bitossi, M. ; Blake, S. ; Blanch Bigas, O. ; Blasi, P. ; Bobkov, A. A. ; Boccone, V. ; Boettcher, Markus ; Bogacz, L. ; Bogart, J. ; Bogdan, M. ; Boisson, Catherine ; Boix Gargallo, J. ; Bolmont, J. ; Bonanno, G. ; Bonardi, A. ; Bonev, T. ; Bonifacio, P. ; Bonnoli, G. ; Bordas, Pol ; Borgland, A. W. ; Borkowski, Janett ; Bose, R. ; Botner, O. ; Bottani, A. ; Bouchet, L. ; Bourgeat, M. ; Boutonnet, C. ; Bouvier, A. ; Brau-Nogue, S. ; Braun, I. ; Bretz, T. ; Briggs, M. S. ; Bringmann, T. ; Brook, P. ; Brun, Pierre ; Brunetti, L. ; Buanes, T. ; Buckley, J. H. ; Buehler, R. ; Bugaev, V. ; Bulgarelli, A. ; Bulik, Tomasz ; Busetto, G. ; Buson, S. ; Byrum, K. ; Cailles, M. ; Cameron, R. A. ; Camprecios, J. ; Canestrari, R. ; Cantu, S. ; Capalbi, M. ; Caraveo, P. A. ; Carmona, E. ; Carosi, A. ; Carr, John ; Carton, P. H. ; Casanova, Sabrina ; Casiraghi, M. ; Catalano, O. ; Cavazzani, S. ; Cazaux, S. ; Cerruti, M. ; Chabanne, E. ; Chadwick, Paula M. ; Champion, C. ; Chen, Andrew ; Chiang, J. ; Chiappetti, L. ; Chikawa, M. ; Chitnis, V. R. ; Chollet, F. ; Chudoba, J. ; Cieslar, M. ; Cillis, A. N. ; Cohen-Tanugi, J. ; Colafrancesco, Sergio ; Colin, P. ; Calome, J. ; Colonges, S. ; Compin, M. ; Conconi, P. ; Conforti, V. ; Connaughton, V. ; Conrad, Jan ; Contreras, J. L. ; Coppi, P. ; Corona, P. ; Corti, D. ; Cortina, J. ; Cossio, L. ; Costantini, H. ; Cotter, G. ; Courty, B. ; Couturier, S. ; Covino, S. ; Crimi, G. ; Criswell, S. J. ; Croston, J. ; Cusumano, G. ; Dafonseca, M. ; Dale, O. ; Daniel, M. ; Darling, J. ; Davids, I. ; Dazzi, F. ; De Angelis, A. ; De Caprio, V. ; De Frondat, F. ; de Gouveia Dal Pino, E. M. ; de la Calle, I. ; De La Vega, G. A. ; Lopez, R. de los Reyes ; De Lotto, B. ; De Luca, A. ; de Mello Neto, J. R. 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The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project.
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