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RailChain
(2023)
The RailChain project designed, implemented, and experimentally evaluated a juridical recorder that is based on a distributed consensus protocol. That juridical blockchain recorder has been realized as distributed ledger on board the advanced TrainLab (ICE-TD 605 017) of Deutsche Bahn.
For the project, a consortium consisting of DB Systel, Siemens, Siemens Mobility, the Hasso Plattner Institute for Digital Engineering, Technische Universität Braunschweig, TÜV Rheinland InterTraffic, and Spherity has been formed. These partners not only concentrated competencies in railway operation, computer science, regulation, and approval, but also combined experiences from industry, research from academia, and enthusiasm from startups.
Distributed ledger technologies (DLTs) define distributed databases and express a digital protocol for transactions between business partners without the need for a trusted intermediary. The implementation of a blockchain with real-time requirements for the local network of a railway system (e.g., interlocking or train) allows to log data in the distributed system verifiably in real-time. For this, railway-specific assumptions can be leveraged to make modifications to standard blockchains protocols.
EULYNX and OCORA (Open CCS On-board Reference Architecture) are parts of a future European reference architecture for control command and signalling (CCS, Reference CCS Architecture – RCA). Both architectural concepts outline heterogeneous IT systems with components from multiple manufacturers. Such systems introduce novel challenges for the approved and safety-relevant CCS of railways which were considered neither for road-side nor for on-board systems so far. Logging implementations, such as the common juridical recorder on vehicles, can no longer be realized as a central component of a single manufacturer. All centralized approaches are in question.
The research project RailChain is funded by the mFUND program and gives practical evidence that distributed consensus protocols are a proper means to immutably (for legal purposes) store state information of many system components from multiple manufacturers. The results of RailChain have been published, prototypically implemented, and experimentally evaluated in large-scale field tests on the advanced TrainLab. At the same time, the project showed how RailChain can be integrated into the road-side and on-board architecture given by OCORA and EULYNX.
Logged data can now be analysed sooner and also their trustworthiness is being increased. This enables, e.g., auditable predictive maintenance, because it is ensured that data is authentic and unmodified at any point in time.
As a non-contact process laser beam melt ablation offers several advantages compared to conventional processing mechanisms. During ablation the surface of the workpiece is molten by the energy of a CO2-laser beam, this melt is then driven out by the impulse of an additional process gas. Although the idea behind laser beam melt ablation is rather simple, the process itself has a major limitation in practical applications: with increasing ablation rate surface quality of the workpiece processed declines rapidly. With different ablation rates different surface structures can be distinguished, which can be characterised by suitable surface parameters. The corresponding regimes of pattern formation are found in linear and non-linear statistical properties of the recorded process emissions as well. While the ablation rate can be represented in terms of the line-energy, this parameter does not provide sufficient information about the full behaviour of the system. The dynamics of the system is dominated by oscillations due to the laser cycle but includes some periodically driven non-linear processes as well. Upon the basis of the measured time series, a corresponding model is developed. The deeper understanding of the process can be used to develop strategies for a process control.
As a non-contact process laser beam melt ablation offers several advantages compared to conventional processing mechanisms. During ablation the surface of the workpiece is molten by the energy of a CO2-laser beam, this melt is then driven out by the impulse of an additional process gas. Although the idea behind laser beam melt ablation is rather simple, the process itself has a major limitation in practical applications: with increasing ablation rate surface quality of the workpiece processed declines rapidly. With different ablation rates different surface structures can be distinguished, which can be characterised by suitable surface parameters. The corresponding regimes of pattern formation are found in linear and non-linear statistical properties of the recorded process emissions as well. While the ablation rate can be represented in terms of the line-energy, this parameter does not provide sufficient information about the full behaviour of the system. The dynamics of the system is dominated by oscillations due to the laser cycle but includes some periodically driven non-linear processes as well. Upon the basis of the measured time series, a corresponding model is developed. The deeper understanding of the process can be used to develop strategies for a process control.
Towards a better understanding of laser beam melt ablation using methods of statistical analysis
(2002)
Laser beam melt ablation, as a contact free machining process, offers several advantages compared to conventional processing mechanisms. Although the idea behind it is rather simple, the process has a major limitation: with increasing ablation rate surface quality of the workpiece processed declines rapidly. The structures observed show a clear dependence of the line energy. In dependence of this parameter several regimes of the process have been separated. These are clearly distinguishable as well in the surfaces obtained as in the signals gained by the measurement of the process emissions which is the observed quantity chosen.
Background
High blood glucose and diabetes are amongst the conditions causing the greatest losses in years of healthy life worldwide. Therefore, numerous studies aim to identify reliable risk markers for development of impaired glucose metabolism and type 2 diabetes. However, the molecular basis of impaired glucose metabolism is so far insufficiently understood. The development of so called 'omics' approaches in the recent years promises to identify molecular markers and to further understand the molecular basis of impaired glucose metabolism and type 2 diabetes. Although univariate statistical approaches are often applied, we demonstrate here that the application of multivariate statistical approaches is highly recommended to fully capture the complexity of data gained using high-throughput methods.
Methods
We took blood plasma samples from 172 subjects who participated in the prospective Metabolic Syndrome Berlin Potsdam follow-up study (MESY-BEPO Follow-up). We analysed these samples using Gas Chromatography coupled with Mass Spectrometry (GC-MS), and measured 286 metabolites. Furthermore, fasting glucose levels were measured using standard methods at baseline, and after an average of six years. We did correlation analysis and built linear regression models as well as Random Forest regression models to identify metabolites that predict the development of fasting glucose in our cohort.
Results
We found a metabolic pattern consisting of nine metabolites that predicted fasting glucose development with an accuracy of 0.47 in tenfold cross-validation using Random Forest regression. We also showed that adding established risk markers did not improve the model accuracy. However, external validation is eventually desirable. Although not all metabolites belonging to the final pattern are identified yet, the pattern directs attention to amino acid metabolism, energy metabolism and redox homeostasis.
Conclusions
We demonstrate that metabolites identified using a high-throughput method (GC-MS) perform well in predicting the development of fasting plasma glucose over several years. Notably, not single, but a complex pattern of metabolites propels the prediction and therefore reflects the complexity of the underlying molecular mechanisms. This result could only be captured by application of multivariate statistical approaches. Therefore, we highly recommend the usage of statistical methods that seize the complexity of the information given by high-throughput methods.
Die Rolle des Staats in der sozialen Marktwirtschaft bei Globalisierung der Wirtschaftsbeziehungen
(1997)
Awards
(2013)
Objective: Retinol is transported in a complex with retinol-binding protein 4 (RBP4) and transthyretin (TTR) in the circulation. While retinol is associated with various cardiovascular risk factors, the relation between retinol, RBP4, TTR and carotid intima media thickness (IMT) has not been analysed yet. Methods: Retinol, RBP4 and TTR were measured in 96 individuals and their relation to mean and maximal IMT was determined. Results: Mean IMT correlated with RBP4 (r = 0.335, p < 0.001), retinol (r = -0.241, p = 0.043), RBP/TTR ratio (r = 0.254, p = 0.025) and retinol/RBP4 ratio (r = -0.549, p < 0.001). Adjustment for age, sex, BMI, blood pressure, HDL/total cholesterol ratio, triglyceride, diabetes and smoking revealed that the retinol/RBP4 ratio was strongly and independently associated with mean IMT. Similar results were found for maximal IMT, which included the measurement of plaques. Conclusion: The data support that the transport complex of vitamin A is associated with the IMT, an established parameter of atherosclerosis. Changes in RBP4 saturation with retinol may link renal dysfunction and insulin resistance to atherosclerosis.