Refine
Year of publication
Document Type
- Article (182)
- Postprint (8)
- Monograph/Edited Volume (6)
- Review (3)
- Conference Proceeding (2)
- Doctoral Thesis (2)
- Other (1)
- Part of Periodical (1)
- Preprint (1)
Is part of the Bibliography
- yes (206) (remove)
Keywords
- longitudinal study (9)
- Mannheim Study of Children at Risk (8)
- Längsschnittstudie (7)
- Mannheimer Risikokinderstudie (6)
- Adolescence (4)
- DRD4 (4)
- Depression (4)
- Gene-environment interaction (4)
- ADHD (3)
- Cortisol (3)
- Longitudinal study (3)
- Stress (3)
- fMRI (3)
- forestREplot (3)
- Aggression (2)
- Child Behavior Checklist-Dysregulation Profile (2)
- Childhood (2)
- Duchenne muscular dystrophy (2)
- Dysregulation (2)
- Early psychosocial adversity (2)
- Edge effects (2)
- Elternverhalten (2)
- Entwicklung (2)
- Externalizing behavior (2)
- Frühgeburt (2)
- HPA (2)
- MAOA (2)
- Michael addition (2)
- Mother-infant interaction (2)
- Mutter-Kind-Interaktion (2)
- Prenatal stress (2)
- Risikofaktoren (2)
- Schutzfaktoren (2)
- Young adulthood (2)
- acute kidney injury (2)
- aggression (2)
- amygdala (2)
- child development (2)
- cognitive development (2)
- conduct disorder (2)
- development (2)
- developmental psychopathology (2)
- diffusion (2)
- early adversity (2)
- early parent-child relationship (2)
- embodied cognition (2)
- end-stage kidney disease (2)
- forest management (2)
- frühe Eltern-Kind-Beziehung (2)
- gene-environment interaction (2)
- genome-wide association (2)
- hydrodynamics (2)
- kognitive Entwicklung (2)
- mathematics (2)
- microwave irradiation (2)
- neuromuscular disease (2)
- numerical processing (2)
- parental quality (2)
- planets and satellites: rings (2)
- postpartum depression (2)
- preterm birth (2)
- protective factors (2)
- rapid eGFRcrea decline (2)
- resilience (2)
- risk factors (2)
- risk research (2)
- spatial-numerical associations (2)
- spinal muscular atrophy (2)
- study (2)
- tandem reaction (2)
- transition zone (2)
- ventral striatum (2)
- 3D flower superstructures (1)
- 5-HTTLPR (1)
- ACTH (1)
- Abgaben (1)
- Abgabenbescheide (1)
- Adolescents (1)
- Age at First Drink (1)
- Air showers (1)
- Allylic compounds (1)
- Arenes (1)
- Attention-deficit/hyperactivity disorder (1)
- Ausbildung (1)
- BDNF (1)
- Bahnwesen (1)
- Beiträge (1)
- Benzene (1)
- Biaryls (1)
- Biodegradation (1)
- Biodiversity Exploratories (1)
- Blockchain (1)
- C. elegans (1)
- CBCL (1)
- CNR1 (1)
- Canopy (1)
- Carbon (1)
- Catabolic genes (1)
- Catechol-O-methyltransferase gene (1)
- Central Asia (1)
- Cherenkov Telescopes (1)
- Child Behavior Checklist-Dysregulationsprofil (1)
- Childhood adversity (1)
- Children (1)
- Chronosequence (1)
- Claisen rearrangement (1)
- Coesite-bearing eclogite (1)
- Content analysis (1)
- Continuous performance task (1)
- Corticotropin-releasing hormone receptor 1 gene (1)
- Cover abundance (1)
- Cross-coupling (1)
- Daily Hassles (1)
- Design concepts (1)
- Didaktik (1)
- Digitalisierung (1)
- Distributed-Ledger-Technologie (DLT) (1)
- Drinking Behavior (1)
- EDX (1)
- Early adversity (1)
- Early maternal care (1)
- Echtzeit (1)
- Ecological boundaries (1)
- Ecosystem services (1)
- Ecotone hierarchy (1)
- Entwicklungspsychopathologie (1)
- Environmental gradients (1)
- Epigenetic (1)
- Externalizing disorders (1)
- FKBP5 (1)
- Fagus sylvatica (1)
- Family adversity (1)
- Feedback (1)
- Fehlertoleranz (1)
- Fragmentation (1)
- Fragmentierung (1)
- Framework quantitative ecology (1)
- G3BP (1)
- Gebühren (1)
- Genetic association (1)
- Global change (1)
- Glucocorticoid receptor (1)
- Ground based gamma ray astronomy (1)
- GxE interaction (1)
- HMF oxidation (1)
- HPA axis (1)
- Herb layer (1)
- Hochschuldidaktik (1)
- Human (1)
- Impulsivity (1)
- Infancy (1)
- Infant regulatory problems (1)
- Informatik (1)
- Interaction (1)
- Internalizing behavior (1)
- KAG (1)
- Konsensprotokolle (1)
- Land use management (1)
- Landscape features (1)
- Landscape visualisation (1)
- Laser ICP-MS (1)
- Lehrkräftebildung (1)
- Longitudinal (1)
- Longitudinal Study (1)
- MOF-derived catalysts (1)
- MTBE (1)
- Magma migration and fragmentation (1)
- Maltreatment (1)
- Mannheimer+Risikokinderstudie (1)
- Matter cycling (1)
- Matter dynamics (1)
- Methylation (1)
- Microscopy (1)
- Microwave chemistry (1)
- Molecular heterosis (1)
- N-2 fixation (1)
- N-2 reduction (1)
- Natural products (1)
- Neuropeptide Y (1)
- Next generation Cherenkov telescopes (1)
- Nitrogen (1)
- Nitrogen deposition (1)
- Non-monetary valuation (1)
- Norepinephrine transporter (1)
- Numerical modeling (1)
- Operationalisation (1)
- Oxygen heterocycles (1)
- PPGIS (1)
- Palladium (1)
- Parent-child-interaction (1)
- Parenting (1)
- Parenting quality (1)
- Participatory mapping (1)
- Pflanzenwachstumsmodellierung (1)
- Phenols (1)
- Picea abies (1)
- Pigments (1)
- Pinus sylvestris (1)
- Polymorphism (1)
- Postpartale Depression (1)
- Postpartale+Depression (1)
- Problematic cannabis use (1)
- Pseudotsuga menziesii (1)
- Psychosoziales Risiko (1)
- Pyrimidines (1)
- Radon (1)
- Raman spectroscopy (1)
- Randeffekte (1)
- Rare earth element (REE) distribution (1)
- Rearrangement (1)
- Reflection (1)
- Reflection Skills (1)
- Reflexion (1)
- Reflexionskompetenz (1)
- Reflexivity (1)
- Reflexivität (1)
- Risikoforschung (1)
- SAFIRA II (1)
- SIRT6 (1)
- Self-report (1)
- Sex (1)
- Shannon diversity (1)
- Silk Road (1)
- Sirtuins (1)
- Smoking during pregnancy (1)
- Spatiotemporal resurvey data (1)
- Stable isotope fractionation analysis (1)
- Standardisierung (1)
- Steuern (1)
- Stress granules (1)
- Stressful Life Events (1)
- TBTU (1)
- TeV gamma-ray astronomy (1)
- Teacher Education (1)
- Temperament (1)
- Temperate forest (1)
- Total synthesis (1)
- Tracers (1)
- Tree regeneration (1)
- Tso Morari (1)
- Ultra-high pressure (UHP) (1)
- VOCs (1)
- Values (1)
- Verlässlichkeit (1)
- Visitors (1)
- Visualisation tool (1)
- Volatilization (1)
- Volcano monitoring (1)
- Volcano seismology (1)
- Wacker reaction (1)
- Wall paintings (1)
- Waveform inversion (1)
- XRF (1)
- Young adults (1)
- academic self-concept (1)
- adolescents (1)
- age at first cigarette (1)
- agricultural modelling (1)
- alcohol use (1)
- alcohol-related problems (1)
- aldehydes (1)
- ammonia synthesis (1)
- anion substitution (1)
- antisocial (1)
- anxiety disorders (1)
- asset management (1)
- atmospheric effects (1)
- atmospheric nitrogen deposition (1)
- biodiversity change (1)
- bipolar (1)
- celestial mechanics (1)
- childhood (1)
- childhood adversity (1)
- chromenes (1)
- climate change (1)
- comorbidity (1)
- consensus protocols (1)
- coping styles (1)
- coumarins (1)
- crop growth (1)
- crustal magma chamber (1)
- cyclization (1)
- decentral identities (1)
- deep low-frequency earthquakes (1)
- dependability (1)
- dependence (1)
- depression (1)
- dezentrale Identitäten (1)
- didactics (1)
- digitalization (1)
- dimensional comparisons (1)
- distributed volcanic fields (1)
- disturbance regime (1)
- dynamics (1)
- early smoking experiences (1)
- ecosystem services (1)
- ecotones (1)
- edge effect (1)
- edge effects (1)
- education (1)
- electroencephalography (1)
- elementary school students (1)
- evenness (1)
- fault tolerance (1)
- field (1)
- field boundaries (1)
- forest conversion (1)
- forested headwater catchment (1)
- fragmentation (1)
- frame of reference (1)
- functional magnetic resonance imaging (1)
- functional traits (1)
- game browsing (1)
- gamma diversity (1)
- gender (1)
- globular clusters: individual: NGC 6656 (1)
- herbaceous layer (1)
- heteroatoms (1)
- hierarchically porous carbon (1)
- higher education (1)
- informatics (1)
- infrared: diffuse background (1)
- inhibition AChE (1)
- instrumentation: miscellaneous (1)
- internal/external frame-of-reference model (1)
- irritability (1)
- juridical recording (1)
- ketones (1)
- land-use conflicts (1)
- landscape complexity; (1)
- landscape scale (1)
- life stress (1)
- local knowledge (1)
- longitudinal (1)
- low velocity zone (1)
- magma reservoirs (1)
- maize (1)
- management intensity (1)
- maternal care (1)
- maternal distress (1)
- metal-organic mesocrystals (1)
- mitsunobu (1)
- moisture observing system (1)
- mood disorders (1)
- mother-child interaction (1)
- mother–child interaction (1)
- networks (1)
- nitrogen deposition (1)
- non-metal catalysis (1)
- non-noble metal catalysts (1)
- novae, cataclysmic variables (1)
- observatories (1)
- olefination (1)
- onshore wind (1)
- parameterization methods (1)
- parenting (1)
- perigenual anterior cingulate cortex (1)
- phenols (1)
- planning constraints (1)
- plant functional traits (1)
- pleasurable smoking sensations (1)
- porous carbon (1)
- preadolescent depression (1)
- protecting groups (1)
- puberty (1)
- railways (1)
- real-time (1)
- rearrangement (1)
- reflection seismic (1)
- research priorities (1)
- resource assessments (1)
- reward processing (1)
- scale (1)
- scattering (1)
- selbstbestimmte Identitäten (1)
- self-sovereign identity (1)
- social acceptance (1)
- soil-water content (1)
- solar irradiance (1)
- spatiotemporal resurvey data (1)
- species richness (1)
- spillovers (1)
- standardization (1)
- substance use (1)
- suicidality (1)
- techniques: imaging spectroscopy (1)
- temperament (1)
- thermal transformation mechanism (1)
- time lag (1)
- tree species diversity (1)
- vegetation resurvey (1)
- verifiable credentials (1)
- wheat (1)
- ylides (1)
- Ökosystemleistungen (1)
- Übergangszone (1)
- überprüfbare Nachweise (1)
Institute
- Department Psychologie (124)
- Institut für Chemie (16)
- Institut für Biochemie und Biologie (13)
- Institut für Physik und Astronomie (11)
- Institut für Geowissenschaften (10)
- Institut für Umweltwissenschaften und Geographie (10)
- Hasso-Plattner-Institut für Digital Engineering GmbH (4)
- Humanwissenschaftliche Fakultät (4)
- Institut für Mathematik (4)
- Department Erziehungswissenschaft (2)
A catalog of genetic loci associated with kidney function from analyses of a million individuals
(2019)
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
Kleine Geschichte Spaniens
(2004)
Understorey plant communities play a key role in the functioning of forest ecosystems. Under favourable environmental conditions, competitive understorey species may develop high abundances and influence important ecosystem processes such as tree regeneration. Thus, understanding and predicting the response of competitive understorey species as a function of changing environmental conditions is important for forest managers. In the absence of sufficient temporal data to quantify actual vegetation changes, space-for-time (SFT) substitution is often used, i.e. studies that use environmental gradients across space to infer vegetation responses to environmental change over time. Here we assess the validity of such SFT approaches and analysed 36 resurvey studies from ancient forests with low levels of recent disturbances across temperate Europe to assess how six competitive understorey plant species respond to gradients of overstorey cover, soil conditions, atmospheric N deposition and climatic conditions over space and time. The combination of historical and contemporary surveys allows (i) to test if observed contemporary patterns across space are consistent at the time of the historical survey, and, crucially, (ii) to assess whether changes in abundance over time given recorded environmental change match expectations from patterns recorded along environmental gradients in space. We found consistent spatial relationships at the two periods: local variation in soil variables and overstorey cover were the best predictors of individual species’ cover while interregional variation in coarse-scale variables, i.e. N deposition and climate, was less important. However, we found that our SFT approach could not accurately explain the large variation in abundance changes over time. We thus recommend to be cautious when using SFT substitution to infer species responses to temporal changes.
Global biodiversity is affected by numerous environmental drivers. Yet, the extent to which global environmental changes contribute to changes in local diversity is poorly understood. We investigated biodiversity changes in a meta-analysis of 39 resurvey studies in European temperate forests (3988 vegetation records in total, 17-75years between the two surveys) by assessing the importance of (i) coarse-resolution (i.e., among sites) vs. fine-resolution (i.e., within sites) environmental differences and (ii) changing environmental conditions between surveys. Our results clarify the mechanisms underlying the direction and magnitude of local-scale biodiversity changes. While not detecting any net local diversity loss, we observed considerable among-site variation, partly explained by temporal changes in light availability (a local driver) and density of large herbivores (a regional driver). Furthermore, strong evidence was found that presurvey levels of nitrogen deposition determined subsequent diversity changes. We conclude that models forecasting future biodiversity changes should consider coarse-resolution environmental changes, account for differences in baseline environmental conditions and for local changes in fine-resolution environmental conditions.
Reflexion ist eine Schlüsselkategorie für die professionelle Entwicklung von Lehrkräften, welche als Ausbildungsziel in den Bildungsstandards für die Lehrkräftebildung verankert ist. Eine Verstetigung universitär geprägter Forschung und Modellierung in der praxisnahen Anwendung im schulischen Kontext bietet Potentiale nachhaltiger Professionalisierung. Die Stärkung reflexionsbezogener Kompetenzen durch Empirie und Anwendung scheint eine phasenübergreifende Herausforderung der Lehrkräftebildung zu sein, die es zu bewältigen gilt. Ziele des Tagungsbandes Reflexion in der Lehrkräftebildung sind eine theoretische Schärfung des Konzeptes „Reflexive Professionalisierung“ und der Austausch über Fragen der Einbettung wirksamer reflexionsbezogener Lerngelegenheiten in die Lehrkräftebildung. Forschende und Lehrende der‚ drei Phasen (Studium, Referendariat sowie Fort- und Weiterbildung) der Lehrkräftebildung stellen Lehrkonzepte und Forschungsprojekte zum Thema Reflexion in der Lehrkräftebildung vor und diskutieren diese. Gemeinsam mit Teilnehmenden aller Phasen und von verschiedenen Standorten der Lehrkräftebildung werden zukünftige Herausforderungen identifiziert und Lösungsansätze herausgearbeitet.
Moving in the Anthropocene
(2018)
Animal movement is fundamental for ecosystem functioning and species survival, yet the effects of the anthropogenic footprint on animal movements have not been estimated across species. Using a unique GPS-tracking database of 803 individuals across 57 species, we found that movements of mammals in areas with a comparatively high human footprint were on average one-half to one-third the extent of their movements in areas with a low human footprint. We attribute this reduction to behavioral changes of individual animals and to the exclusion of species with long-range movements from areas with higher human impact. Global loss of vagility alters a key ecological trait of animals that affects not only population persistence but also ecosystem processes such as predator-prey interactions, nutrient cycling, and disease transmission.
Das Kommunalabgabengesetz für das Land Brandenburg (KAG) ist eine für alle Kommunalverwaltungen, Zweckverbände und Anwälte wichtige Rechtsmaterie. Den 20 Paragrafen steht eine Fülle von Fragen nach Auslegung und Anwendung des Gesetzes gegenüber, die von der Rechtsprechung mit zahlreichen Entscheidungen beantwortet werden.
Mit dem Werk "Kommunalabgabengesetz für das Land Brandenburg" liegt ein umfassender Kommentar vor, der sich mit der Auslegung des brandenburgischen Kommunalabgabengesetzes (KAG) und der dazu ergangenen Rechtsprechung befasst. Die zahlreichsten Gerichtsentscheidungen beinhaltet die Kommentierung zu § 6 (Benutzungsgebühren) Einerseits darf der Titel für sich in Anspruch nehmen, auch nicht speziell juristisch ausgebildete Nutzer in die Rechtsvorschriften zum KAG Brandenburg einzuführen. Andererseits will es aber auch den mit dem Abgabenrecht befassten Fachleuten in Verwaltungen, Verbänden, Gerichten und Kanzleien eine solide Grundlage für möglichst rechtssichere Entscheidungen bieten.
Der engen räumlichen Nähe wegen beinhaltet das Werk die Abgabenrechtlichen Vorschriften des Landes Berlin.
Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.
Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.