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Aarts, Alexander A. ; Anderson, Joanna E. ; Anderson, Christopher J. ; Attridge, Peter R. ; Attwood, Angela ; Axt, Jordan ; Babel, Molly ; Bahnik, Stepan ; Baranski, Erica ; Barnett-Cowan, Michael ; Bartmess, Elizabeth ; Beer, Jennifer ; Bell, Raoul ; Bentley, Heather ; Beyan, Leah ; Binion, Grace ; Borsboom, Denny ; Bosch, Annick ; Bosco, Frank A. ; Bowman, Sara D. ; Brandt, Mark J. ; Braswell, Erin ; Brohmer, Hilmar ; Brown, Benjamin T. ; Brown, Kristina ; Bruening, Jovita ; Calhoun-Sauls, Ann ; Callahan, Shannon P. ; Chagnon, Elizabeth ; Chandler, Jesse ; Chartier, Christopher R. ; Cheung, Felix ; Christopherson, Cody D. ; Cillessen, Linda ; Clay, Russ ; Cleary, Hayley ; Cloud, Mark D. ; Cohn, Michael ; Cohoon, Johanna ; Columbus, Simon ; Cordes, Andreas ; Costantini, Giulio ; Alvarez, Leslie D. Cramblet ; Cremata, Ed ; Crusius, Jan ; DeCoster, Jamie ; DeGaetano, Michelle A. ; Della Penna, Nicolas ; den Bezemer, Bobby ; Deserno, Marie K. ; Devitt, Olivia ; Dewitte, Laura ; Dobolyi, David G. ; Dodson, Geneva T. ; Donnellan, M. Brent ; Donohue, Ryan ; Dore, Rebecca A. ; Dorrough, Angela ; Dreber, Anna ; Dugas, Michelle ; Dunn, Elizabeth W. ; Easey, Kayleigh ; Eboigbe, Sylvia ; Eggleston, Casey ; Embley, Jo ; Epskamp, Sacha ; Errington, Timothy M. ; Estel, Vivien ; Farach, Frank J. ; Feather, Jenelle ; Fedor, Anna ; Fernandez-Castilla, Belen ; Fiedler, Susann ; Field, James G. ; Fitneva, Stanka A. ; Flagan, Taru ; Forest, Amanda L. ; Forsell, Eskil ; Foster, Joshua D. ; Frank, Michael C. ; Frazier, Rebecca S. ; Fuchs, Heather ; Gable, Philip ; Galak, Jeff ; Galliani, Elisa Maria ; Gampa, Anup ; Garcia, Sara ; Gazarian, Douglas ; Gilbert, Elizabeth ; Giner-Sorolla, Roger ; Glöckner, Andreas ; Göllner, Lars ; Goh, Jin X. ; Goldberg, Rebecca ; Goodbourn, Patrick T. ; Gordon-McKeon, Shauna ; Gorges, Bryan ; Gorges, Jessie ; Goss, Justin ; Graham, Jesse ; Grange, James A. ; Gray, Jeremy ; Hartgerink, Chris ; Hartshorne, Joshua ; Hasselman, Fred ; Hayes, Timothy ; Heikensten, Emma ; Henninger, Felix ; Hodsoll, John ; Holubar, Taylor ; Hoogendoorn, Gea ; Humphries, Denise J. ; Hung, Cathy O. -Y. ; Immelman, Nathali ; Irsik, Vanessa C. ; Jahn, Georg ; Jaekel, Frank ; Jekel, Marc ; Johannesson, Magnus ; Johnson, Larissa G. ; Johnson, David J. ; Johnson, Kate M. ; Johnston, William J. ; Jonas, Kai ; Joy-Gaba, Jennifer A. ; Kappes, Heather Barry ; Kelso, Kim ; Kidwell, Mallory C. ; Kim, Seung Kyung ; Kirkhart, Matthew ; Kleinberg, Bennett ; Knezevic, Goran ; Kolorz, Franziska Maria ; Kossakowski, Jolanda J. ; Krause, Robert Wilhelm ; Krijnen, Job ; Kuhlmann, Tim ; Kunkels, Yoram K. ; Kyc, Megan M. ; Lai, Calvin K. ; Laique, Aamir ; Lakens, Daniel ; Lane, Kristin A. ; Lassetter, Bethany ; Lazarevic, Ljiljana B. ; LeBel, Etienne P. ; Lee, Key Jung ; Lee, Minha ; Lemm, Kristi ; Levitan, Carmel A. ; Lewis, Melissa ; Lin, Lin ; Lin, Stephanie ; Lippold, Matthias ; Loureiro, Darren ; Luteijn, Ilse ; Mackinnon, Sean ; Mainard, Heather N. ; Marigold, Denise C. ; Martin, Daniel P. ; Martinez, Tylar ; Masicampo, E. J. ; Matacotta, Josh ; Mathur, Maya ; May, Michael ; Mechin, Nicole ; Mehta, Pranjal ; Meixner, Johannes ; Melinger, Alissa ; Miller, Jeremy K. ; Miller, Mallorie ; Moore, Katherine ; Möschl, Marcus ; Motyl, Matt ; Müller, Stephanie M. ; Munafo, Marcus ; Neijenhuijs, Koen I. ; Nervi, Taylor ; Nicolas, Gandalf ; Nilsonne, Gustav ; Nosek, Brian A. ; Nuijten, Michele B. ; Olsson, Catherine ; Osborne, Colleen ; Ostkamp, Lutz ; Pavel, Misha ; Penton-Voak, Ian S. ; Perna, Olivia ; Pernet, Cyril ; Perugini, Marco ; Pipitone, R. Nathan ; Pitts, Michael ; Plessow, Franziska ; Prenoveau, Jason M. ; Rahal, Rima-Maria ; Ratliff, Kate A. ; Reinhard, David ; Renkewitz, Frank ; Ricker, Ashley A. ; Rigney, Anastasia ; Rivers, Andrew M. ; Roebke, Mark ; Rutchick, Abraham M. ; Ryan, Robert S. ; Sahin, Onur ; Saide, Anondah ; Sandstrom, Gillian M. ; Santos, David ; Saxe, Rebecca ; Schlegelmilch, Rene ; Schmidt, Kathleen ; Scholz, Sabine ; Seibel, Larissa ; Selterman, Dylan Faulkner ; Shaki, Samuel ; Simpson, William B. ; Sinclair, H. Colleen ; Skorinko, Jeanine L. M. ; Slowik, Agnieszka ; Snyder, Joel S. ; Soderberg, Courtney ; Sonnleitner, Carina ; Spencer, Nick ; Spies, Jeffrey R. ; Steegen, Sara ; Stieger, Stefan ; Strohminger, Nina ; Sullivan, Gavin B. ; Talhelm, Thomas ; Tapia, Megan ; te Dorsthorst, Anniek ; Thomae, Manuela ; Thomas, Sarah L. ; Tio, Pia ; Traets, Frits ; Tsang, Steve ; Tuerlinckx, Francis ; Turchan, Paul ; Valasek, Milan ; Van Aert, Robbie ; van Assen, Marcel ; van Bork, Riet ; van de Ven, Mathijs ; van den Bergh, Don ; van der Hulst, Marije ; van Dooren, Roel ; van Doorn, Johnny ; van Renswoude, Daan R. ; van Rijn, Hedderik ; Vanpaemel, Wolf ; Echeverria, Alejandro Vasquez ; Vazquez, Melissa ; Velez, Natalia ; Vermue, Marieke ; Verschoor, Mark ; Vianello, Michelangelo ; Voracek, Martin ; Vuu, Gina ; Wagenmakers, Eric-Jan ; Weerdmeester, Joanneke ; Welsh, Ashlee ; Westgate, Erin C. ; Wissink, Joeri ; Wood, Michael ; Woods, Andy ; Wright, Emily ; Wu, Sining ; Zeelenberg, Marcel ; Zuni, Kellylynn
Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.
Abdalla, Hassan E. ; Abramowski, Attila ; Aharonian, Felix A. ; Benkhali, Faiçal Ait ; Akhperjanian, A. G. ; Angüner, Ekrem Oǧuzhan ; Arrieta, M. ; Aubert, Pierre ; Backes, Michael ; Balzer, Arnim ; Barnard, Michelle ; Becherini, Yvonne ; Tjus, Julia Becker ; Berge, David ; Bernhard, Sabrina ; Bernlöhr, K. ; Birsin, E. ; Blackwell, R. ; Bottcher, Markus ; Boisson, Catherine ; Bolmont, J. ; Bordas, Pol ; Bregeon, Johan ; Brun, Francois ; Brun, Pierre ; Bryan, Mark ; Bulik, Tomasz ; Capasso, M. ; Carr, John ; Casanova, Sabrina ; Chakraborty, N. ; Chalme-Calvet, R. ; Chaves, Ryan C. G. ; Chen, Andrew ; Chevalier, J. ; Chretien, M. ; Colafrancesco, Sergio ; Cologna, Gabriele ; Condon, B. ; Conrad, Jan ; Couturier, C. ; Cui, Y. ; Davids, I. D. ; Degrange, B. ; Deil, Christoph ; deWilt, P. ; Djannati-Atai, Arache ; Domainko, Wilfried ; Donath, Axel ; Dubus, Guillaume ; Dutson, Kate ; Dyks, J. ; Dyrda, M. ; Edwards, T. ; Egberts, Kathrin ; Eger, P. ; Ernenwein, J. -P. ; Eschbach, S. ; Farnier, C. ; Fegan, Stuart ; Fernandes, M. V. ; Fiasson, A. ; Fontaine, G. ; Foerster, A. ; Funk, S. ; Füßling, Matthias ; Gabici, Stefano ; Gajdus, M. ; Gallant, Y. A. ; Garrigoux, T. ; Giavitto, Gianluca ; Giebels, B. ; Glicenstein, J. F. ; Gottschall, Daniel ; Goyal, A. ; Grondin, M. -H. ; Grudzinska, M. ; Hadasch, Daniela ; Hahn, J. ; Hawkes, J. ; Heinzelmann, G. ; Henri, Gilles ; Hermann, G. ; Hervet, Olivier ; Hillert, A. ; Hinton, James Anthony ; Hofmann, Werner ; Hoischen, Clemens ; Holler, M. ; Horns, D. ; Ivascenko, Alex ; Jacholkowska, A. ; Jamrozy, Marek ; Janiak, M. ; Jankowsky, D. ; Jankowsky, Felix ; Jingo, M. ; Jogler, Tobias ; Jouvin, Lea ; Jung-Richardt, Ira ; Kastendieck, M. A. ; Katarzynski, Krzysztof ; Katz, Uli ; Kerszberg, D. ; Khelifi, B. ; Kieffer, M. ; King, J. ; Klepser, S. ; Klochkov, Dmitry ; Kluzniak, W. ; Kolitzus, D. ; Komin, Nu. ; Kosack, K. ; Krakau, S. ; Kraus, Michael ; Krayzel, F. ; Kruger, P. P. ; Laffon, H. ; Lamanna, G. ; Lau, Jeanie ; Lees, J. -P. ; Lefaucheur, J. ; Lefranc, V. ; Lemiere, A. ; Lemoine-Goumard, M. ; Lenain, J. -P. ; Leser, Eva ; Lohse, Thomas ; Lorentz, M. ; Lui, R. ; Lypova, Iryna ; Marandon, Vincent ; Marcowith, Alexandre ; Mariaud, C. ; Marx, R. ; Maurin, G. ; Maxted, N. ; Mayer, Michael ; Meintjes, Petrus Johannes ; Menzler, U. ; Meyer, Manuel ; Mitchell, A. M. W. ; Moderski, R. ; Mohamed, M. ; Mora, K. ; Moulin, Emmanuel ; Murach, T. ; de Naurois, Mathieu ; Niederwanger, F. ; Niemiec, J. ; Oakes, L. ; Odaka, Hirokazu ; Ohm, Stefan ; Oettl, S. ; Ostrowski, M. ; Oya, I. ; Padovani, Marco ; Panter, M. ; Parsons, R. D. ; Arribas, M. Paz ; Pekeur, N. W. ; Pelletier, G. ; Petrucci, P. -O. ; Peyaud, B. ; Pita, S. ; Poon, Helen ; Prokhorov, Dmitry ; Prokoph, Heike ; Puehlhofer, Gerd ; Punch, Michael ; Quirrenbach, Andreas ; Raab, S. ; Reimer, Anita ; Reimer, Olaf ; Renaud, M. ; de los Reyes, R. ; Rieger, Frank ; Romoli, Carlo ; Rosier-Lees, S. ; Rowell, G. ; Rudak, B. ; Rulten, C. B. ; Sahakian, V. ; Salek, David ; Sanchez, David A. ; Santangelo, Andrea ; Sasaki, Manami ; Schlickeiser, Reinhard ; Schussler, F. ; Schulz, Andreas ; Schwanke, U. ; Schwemmer, S. ; Seyffert, A. S. ; Shafi, N. ; Simoni, R. ; Sol, H. ; Spanier, Felix ; Spengler, G. ; Spiess, F. ; Stawarz, Lukasz ; Steenkamp, R. ; Stegmann, Christian ; Stinzing, F. ; Stycz, K. ; Sushch, Iurii ; Tavernet, J. -P. ; Tavernier, T. ; Taylor, A. M. ; Terrier, R. ; Tluczykont, Martin ; Trichard, C. ; Tuffs, R. ; van der Walt, Johan ; van Eldik, Christopher ; van Soelen, Brian ; Vasileiadis, Georges ; Veh, J. ; Venter, C. ; Viana, A. ; Vincent, P. ; Vink, Jacco ; Voisin, F. ; Voelk, Heinrich J. ; Vuillaume, Thomas ; Wadiasingh, Z. ; Wagner, Stefan J. ; Wagner, P. ; Wagner, R. M. ; White, R. ; Wierzcholska, Alicja ; Willmann, P. ; Woernlein, A. ; Wouters, Denis ; Yang, R. ; Zabalza, Victor ; Zaborov, D. ; Zacharias, M. ; Zdziarski, A. A. ; Zech, Andreas ; Zefi, F. ; Ziegler, A. ; Zywucka, Natalia
The inner region of the Milky Way halo harbors a large amount of dark matter (DM). Given its proximity, it is one of the most promising targets to look for DM. We report on a search for the annihilations of DM particles using gamma-ray observations towards the inner 300 pc of the Milky Way, with the H.E.S.S. array of ground-based Cherenkov telescopes. The analysis is based on a 2D maximum likelihood method using Galactic Center (GC) data accumulated by H.E.S.S. over the last 10 years (2004-2014), and does not show any significant gamma-ray signal above background. Assuming Einasto and Navarro-Frenk-White DM density profiles at the GC, we derive upper limits on the annihilation cross section <sigma nu >. These constraints are the strongest obtained so far in the TeV DM mass range and improve upon previous limits by a factor 5. For the Einasto profile, the constraints reach <sigma nu > values of 6 x 10(-26) cm(3) s(-1) in the W+W- channel for a DM particle mass of 1.5 TeV, and 2 x 10(-26) cm(3) s(-1) in the tau(+)tau(-) channel for a 1 TeV mass. For the first time, ground-based gamma-ray observations have reached sufficient sensitivity to probe <sigma nu > values expected from the thermal relic density for TeV DM particles.
Abramowski, Attila ; Aharonian, Felix A. ; Benkhali, Faical Ait ; Akhperjanian, A. G. ; Angüner, Ekrem Oǧuzhan ; Backes, Michael ; Balenderan, Shangkari ; Balzer, Arnim ; Barnacka, Anna ; Becherini, Yvonne ; Tjus, Julia Becker ; Berge, David ; Bernhard, Sabrina ; Bernlöhr, Konrad ; Birsin, E. ; Biteau, Jonathan ; Böttcher, Markus ; Boisson, Catherine ; Bolmont, J. ; Bordas, Pol ; Bregeon, Johan ; Brun, Francois ; Brun, Pierre ; Bryan, Mark ; Bulik, Tomasz ; Carrigan, Svenja ; Casanova, Sabrina ; Chadwick, Paula M. ; Chakraborty, Nachiketa ; Chalme-Calvet, R. ; Chaves, Ryan C. G. ; Chretien, M. ; Colafrancesco, Sergio ; Cologna, Gabriele ; Conrad, Jan ; Couturier, Claire ; Cui, Yudong ; Davids, Isak Delberth ; Degrange, Bernhard ; Deil, Christoph ; deWilt, P. ; Djannati-Ataï, A. ; Domainko, Wilfried ; Donath, Axel ; Dubus, G. ; Dutson, K. ; Dyks, J. ; Dyrda, M. ; Edwards, Tanya ; Egberts, Kathrin ; Eger, Peter ; Espigat, P. ; Farnier, C. ; Fegan, Stephen ; Feinstein, Fabrice ; Fernandes, Milton Virgilio ; Fernandez, Diane ; Fiasson, A. ; Fontaine, Gerard ; Förster, Andreas ; Fuessling, M. ; Gabici, S. ; Gajdus, M. ; Gallant, Yves A. ; Garrigoux, Tania ; Giavitto, G. ; Giebels, Berrie ; Glicenstein, Jean-Francois ; Gottschall, Daniel ; Grondin, M. -H. ; Grudzinska, M. ; Hadasch, Daniela ; Haeffner, S. ; Hahn, Joachim ; Harris, Jonathan ; Heinzelmann, Götz ; Henri, G. ; Hermann, German ; Hervet, O. ; Hillert, Andreas ; Hinton, James Anthony ; Hofmann, Werner ; Hofverberg, Petter ; Holler, Markus ; Horns, Dieter ; Ivascenko, Alex ; Jacholkowska, A. ; Jahn, C. ; Jamrozy, Marek ; Janiak, M. ; Jankowsky, F. ; Jung-Richardt, I. ; Kastendieck, Max Anton ; Katarzynski, K. ; Katz, U. ; Kaufmann, S. ; Khelifi, B. ; Kieffer, Michel ; Klepser, S. ; Klochkov, Dmitry ; Kluzniak, W. ; Kolitzus, David ; Komin, Nu ; Kosack, Karl ; Krakau, Steffen ; Krayzel, F. ; Krueger, Pat P. ; Laffon, H. ; Lamanna, G. ; Lefaucheur, J. ; Lefranc, Valentin ; Lemiere, A. ; Lemoine-Goumard, M. ; Lenain, J. -P. ; Lohse, Thomas ; Lopatin, A. ; Lu, Chia-Chun ; Marandon, Vincent ; Marcowith, Alexandre ; Marx, Ramin ; Maurin, G. ; Maxted, Nigel ; Mayer, Michael ; McComb, T. J. Lowry ; Mehault, J. ; Meintjes, P. J. ; Menzler, Ulf ; Meyer, M. ; Mitchell, Alison M. W. ; Moderski, R. ; Mohamed, M. ; Mora, K. ; Moulin, Emmanuel ; Murach, Thomas ; de Naurois, Mathieu ; Niemiec, J. ; Nolan, Sam J. ; Oakes, Louise ; Odaka, Hirokazu ; Ohm, S. ; Optiz, Björn ; Ostrowski, Michal ; Oya, I. ; Panter, Michael ; Parsons, R. Daniel ; Arribas, M. Paz ; Pekeur, Nikki W. ; Pelletier, G. ; Petrucci, P. -O. ; Peyaud, B. ; Pita, S. ; Poon, Helen ; Pühlhofer, Gerd ; Punch, M. ; Quirrenbach, A. ; Raab, S. ; Reichardt, I. ; Reimer, Anita ; Reimer, Olaf ; Renaud, Metz ; de los Reyes, Raquel ; Rieger, Frank ; Romoli, C. ; Rosier-Lees, S. ; Rowell, G. ; Rudak, B. ; Rulten, C. B. ; Sahakian, Vardan ; Salek, D. ; Sanchez, David M. ; Santangelo, Andrea ; Schlickeiser, Reinhard ; Schuessler, F. ; Schulz, A. ; Schwanke, Ullrich ; Schwarzburg, S. ; Schwemmer, S. ; Sol, H. ; Spanier, Felix ; Spengler, G. ; Spies, Franziska ; Stawarz, Lukasz ; Steenkamp, Riaan ; Stegmann, Christian ; Stinzing, F. ; Stycz, K. ; Sushch, Iurii ; Tavernet, J. -P. ; Tavernier, T. ; Taylor, A. M. ; Terrier, R. ; Tluczykont, Martin ; Trichard, C. ; Valerius, K. ; van Eldik, C. ; van Soelen, B. ; Vasileiadis, Georges ; Veh, J. ; Venter, Christo ; Viana, Aion ; Vincent, P. ; Vink, Jacco ; Völk, Heinrich J. ; Volpe, Francesca ; Vorster, Martine ; Vuillaume, T. ; Wagner, S. J. ; Wagner, P. ; Wagner, R. M. ; Ward, Martin ; Weidinger, Matthias ; Weitzel, Quirin ; White, R. ; Wierzcholska, A. ; Willmann, P. ; Woernlein, A. ; Wouters, D. ; Yang, Ruizhi ; Zabalza, Victor ; Zaborov, Dmitry ; Zacharias, M. ; Zdziarski, A. A. ; Zech, Alraune ; Zechlin, Hannes -S.
Zoller, Peter ; Beth, Thomas ; Binosi, D. ; Blatt, Rainer ; Briegel, Hans J. ; Bruss, D. ; Calarco, Tommaso ; Cirac, Juan Ignacio ; Deutsch, David ; Eisert, Jens ; Ekert, Artur ; Fabre, Claude ; Gisin, Nicolas ; Grangiere, P. ; Grassl, Markus ; Haroche, Serge ; Imamoglu, Atac ; Karlson, A. ; Kempe, Julia ; Kouwenhoven, Leo P. ; Kröll, S. ; Leuchs, Gerd ; Lewenstein, Maciej ; Loss, Daniel ; Lütkenhaus, Norbert ; Massar, Serge ; Mooij, J. E. ; Plenio, Martin Bodo ; Polzik, Eugene ; Popescu, Sandu ; Rempe, Gerhard ; Sergienko, Alexander ; Suter, David ; Twamley, John ; Wendin, Göran ; Werner, Reinhard F. ; Winter, Andreas ; Wrachtrup, Jörg ; Zeilinger, Anton
We present an excerpt of the document "Quantum Information Processing and Communication: Strategic report on current status, visions and goals for research in Europe", which has been recently published in electronic form at the website of FET (the Future and Emerging Technologies Unit of the Directorate General Information Society of the European Commission, http://www.cordis.lu/ist/fet/qipc-sr.htm). This document has been elaborated, following a former suggestion by FET, by a committee of QIPC scientists to provide input towards the European Commission for the preparation of the Seventh Framework Program. Besides being a document addressed to policy makers and funding agencies (both at the European and national level), the document contains a detailed scientific assessment of the state-of-the-art, main research goals, challenges, strengths, weaknesses, visions and perspectives of all the most relevant QIPC sub-fields, that we report here
Georgiev, Vasil N. ; Grafmüller, Andrea ; Bléger, David ; Hecht, Stefan ; Kunstmann, Sonja ; Barbirz, Stefanie ; Lipowsky, Reinhard ; Dimova, Rumiana
Biomembranes are constantly remodeled and in cells, these processes are controlled and modulated by an assortment of membrane proteins. Here, it is shown that such remodeling can also be induced by photoresponsive molecules. The morphological control of giant vesicles in the presence of a water-soluble ortho-tetrafluoroazobenzene photoswitch (F-azo) is demonstrated and it is shown that the shape transformations are based on an increase in membrane area and generation of spontaneous curvature. The vesicles exhibit budding and the buds can be retracted by using light of a different wavelength. In the presence of F-azo, the membrane area can increase by more than 5% as assessed from vesicle electrodeformation. To elucidate the underlying molecular mechanism and the partitioning of F-azo in the membrane, molecular dynamics simulations are employed. Comparison with theoretically calculated shapes reveals that the budded shapes are governed by curvature elasticity, that the spontaneous curvature can be decomposed into a local and a nonlocal contribution, and that the local spontaneous curvature is about 1/(2.5 mu m). The results show that exo- and endocytotic events can be controlled by light and that these photoinduced processes provide an attractive method to change membrane area and morphology.
Miller, Reinhard ; Li, Junbai ; Wüstneck, Rainer ; Krägel, Jürgen ; Clark, David C. ; Neumann, Wilhelm A.
Dynamic surface tension and surface shear rheology studies of mixed - lactoglobulin/tween 20 systems
(1995)
Evidence of extraneous surfactant adsorption altering adsorbed layer properties of b-lactoglobulin
(1995)
Clark, David C. ; Husband, Fiona ; Wilde, Peter J. ; Cornec, Michel ; Miller, Reinhard ; Krägel, Jürgen ; Wüstneck, Rainer
If a one-dimensional quantum lattice system is subject to one step of a reversible discrete-time dynamics, it is intuitive that as much "quantum information" as moves into any given block of cells from the left, has to exit that block to the right. For two types of such systems - namely quantum walks and cellular automata - we make this intuition precise by defining an index, a quantity that measures the "net flow of quantum information" through the system. The index supplies a complete characterization of two properties of the discrete dynamics. First, two systems S-1, S-2 can be "pieced together", in the sense that there is a system S which acts like S-1 in one region and like S-2 in some other region, if and only if S-1 and S-2 have the same index. Second, the index labels connected components of such systems: equality of the index is necessary and sufficient for the existence of a continuous deformation of S-1 into S-2. In the case of quantum walks, the index is integer-valued, whereas for cellular automata, it takes values in the group of positive rationals. In both cases, the map S bar right arrow. ind S is a group homomorphism if composition of the discrete dynamics is taken as the group law of the quantum systems. Systems with trivial index are precisely those which can be realized by partitioned unitaries, and the prototypes of systems with non-trivial index are shifts.
Chipman, Ariel D. ; Ferrier, David E. K. ; Brena, Carlo ; Qu, Jiaxin ; Hughes, Daniel S. T. ; Schroeder, Reinhard ; Torres-Oliva, Montserrat ; Znassi, Nadia ; Jiang, Huaiyang ; Almeida, Francisca C. ; Alonso, Claudio R. ; Apostolou, Zivkos ; Aqrawi, Peshtewani ; Arthur, Wallace ; Barna, Jennifer C. J. ; Blankenburg, Kerstin P. ; Brites, Daniela ; Capella-Gutierrez, Salvador ; Coyle, Marcus ; Dearden, Peter K. ; Du Pasquier, Louis ; Duncan, Elizabeth J. ; Ebert, Dieter ; Eibner, Cornelius ; Erikson, Galina ; Evans, Peter D. ; Extavour, Cassandra G. ; Francisco, Liezl ; Gabaldon, Toni ; Gillis, William J. ; Goodwin-Horn, Elizabeth A. ; Green, Jack E. ; Griffiths-Jones, Sam ; Grimmelikhuijzen, Cornelis J. P. ; Gubbala, Sai ; Guigo, Roderic ; Han, Yi ; Hauser, Frank ; Havlak, Paul ; Hayden, Luke ; Helbing, Sophie ; Holder, Michael ; Hui, Jerome H. L. ; Hunn, Julia P. ; Hunnekuhl, Vera S. ; Jackson, LaRonda ; Javaid, Mehwish ; Jhangiani, Shalini N. ; Jiggins, Francis M. ; Jones, Tamsin E. ; Kaiser, Tobias S. ; Kalra, Divya ; Kenny, Nathan J. ; Korchina, Viktoriya ; Kovar, Christie L. ; Kraus, F. Bernhard ; Lapraz, Francois ; Lee, Sandra L. ; Lv, Jie ; Mandapat, Christigale ; Manning, Gerard ; Mariotti, Marco ; Mata, Robert ; Mathew, Tittu ; Neumann, Tobias ; Newsham, Irene ; Ngo, Dinh N. ; Ninova, Maria ; Okwuonu, Geoffrey ; Ongeri, Fiona ; Palmer, William J. ; Patil, Shobha ; Patraquim, Pedro ; Pham, Christopher ; Pu, Ling-Ling ; Putman, Nicholas H. ; Rabouille, Catherine ; Ramos, Olivia Mendivil ; Rhodes, Adelaide C. ; Robertson, Helen E. ; Robertson, Hugh M. ; Ronshaugen, Matthew ; Rozas, Julio ; Saada, Nehad ; Sanchez-Gracia, Alejandro ; Scherer, Steven E. ; Schurko, Andrew M. ; Siggens, Kenneth W. ; Simmons, DeNard ; Stief, Anna ; Stolle, Eckart ; Telford, Maximilian J. ; Tessmar-Raible, Kristin ; Thornton, Rebecca ; van der Zee, Maurijn ; von Haeseler, Arndt ; Williams, James M. ; Willis, Judith H. ; Wu, Yuanqing ; Zou, Xiaoyan ; Lawson, Daniel ; Muzny, Donna M. ; Worley, Kim C. ; Gibbs, Richard A. ; Akam, Michael ; Richards, Stephen
Myriapods (e. g., centipedes and millipedes) display a simple homonomous body plan relative to other arthropods. All members of the class are terrestrial, but they attained terrestriality independently of insects. Myriapoda is the only arthropod class not represented by a sequenced genome. We present an analysis of the genome of the centipede Strigamia maritima. It retains a compact genome that has undergone less gene loss and shuffling than previously sequenced arthropods, and many orthologues of genes conserved from the bilaterian ancestor that have been lost in insects. Our analysis locates many genes in conserved macro-synteny contexts, and many small-scale examples of gene clustering. We describe several examples where S. maritima shows different solutions from insects to similar problems. The insect olfactory receptor gene family is absent from S. maritima, and olfaction in air is likely effected by expansion of other receptor gene families. For some genes S. maritima has evolved paralogues to generate coding sequence diversity, where insects use alternate splicing. This is most striking for the Dscam gene, which in Drosophila generates more than 100,000 alternate splice forms, but in S. maritima is encoded by over 100 paralogues. We see an intriguing linkage between the absence of any known photosensory proteins in a blind organism and the additional absence of canonical circadian clock genes. The phylogenetic position of myriapods allows us to identify where in arthropod phylogeny several particular molecular mechanisms and traits emerged. For example, we conclude that juvenile hormone signalling evolved with the emergence of the exoskeleton in the arthropods and that RR-1 containing cuticle proteins evolved in the lineage leading to Mandibulata. We also identify when various gene expansions and losses occurred. The genome of S. maritima offers us a unique glimpse into the ancestral arthropod genome, while also displaying many adaptations to its specific life history.
Georgiev, Vasil N. ; Grafmüller, Andrea ; Bléger, David ; Hecht, Stefan ; Kunstmann, Ruth Sonja ; Barbirz, Stefanie ; Lipowsky, Reinhard ; Dimova, Rumiana
Biomembranes are constantly remodeled and in cells, these processes are controlled and modulated by an assortment of membrane proteins. Here, it is shown that such remodeling can also be induced by photoresponsive molecules. The morphological control of giant vesicles in the presence of a water-soluble ortho-tetrafluoroazobenzene photoswitch (F-azo) is demonstrated and it is shown that the shape transformations are based on an increase in membrane area and generation of spontaneous curvature. The vesicles exhibit budding and the buds can be retracted by using light of a different wavelength. In the presence of F-azo, the membrane area can increase by more than 5% as assessed from vesicle electrodeformation. To elucidate the underlying molecular mechanism and the partitioning of F-azo in the membrane, molecular dynamics simulations are employed. Comparison with theoretically calculated shapes reveals that the budded shapes are governed by curvature elasticity, that the spontaneous curvature can be decomposed into a local and a nonlocal contribution, and that the local spontaneous curvature is about 1/(2.5 mu m). The results show that exo- and endocytotic events can be controlled by light and that these photoinduced processes provide an attractive method to change membrane area and morphology.
Blankenstein, David ; Korneffel, Peter ; Borchart de Moreno, Christiana ; Schwarz, Ingo ; Tkach, Natalia ; Braun, Uwe ; Röser, Martin ; Hoppe, Günter ; Andress, Reinhard
-David Blankenstein, Peter Korneffel: Eine Dauerausstellung über Alexander von Humboldt in der Casa Humboldt in Havanna – der Weg zum ersten Alexander von Humboldt-Museum der Welt
-Christiana Borchart de Moreno: “El favor de la Corte abre todas las puertas”. Aspectos políticos del viaje americano de Alexander von Humboldt
-Ingo Schwarz: Bernhard von Lepels Ode An Humboldt Ein Beitrag zum Theodor-Fontane-Jahr 2019
-Natalia Tkach, Uwe Braun, Martin Röser: Alexander von Humboldts und Aimé Bonplands Pflanzen im Herbarium der Universität Halle-Wittenberg
-Günter Hoppe: Alexander von Humboldts Einstellung zum Sammeln(mit einer Einführung von Carmen Götz und Ingo Schwarz: Günter Hoppe zum 100. Geburtstag am 17. Juni 2019)
-Reinhard Andress: Addendum: a second Poem by Eduard Dorsch on the occasion of Humboldt’s 100th birthday
Schimka, Selina ; Santer, Svetlana ; Mujkic-Ninnemann, Nina M. ; Bleger, David ; Hartmann, Laura ; Wehle, Marko ; Lipowsky, Reinhard ; Santer, Mark
Light-induced DNA compaction as part of nonviral gene delivery was investigated intensively in the past years, although the bridging between the artificial light switchable compacting.agents and biodompatible light insensitive compacting agents was not achieved until now. In this paper, we report on light-induced compaction and decompaction of DNA molecules in the presence of a new typeof agent, a multivalent cationic peptidomimetic molecule containing a photosensitive Azo-group as a branch (Azo-PM). Az-o-PM is synthesized using a solid-phase procedure during Which anrazoberizene unit is attached as a side chain to an Oligo(arnidoamine) backbone. We shoW, that within a-certain Tange,of concentrations and under illumination with light of appropriate-wavelengths, these cationic Molecules induce reversible DNA compaction/decompaction by photo-isomerization of the incorporated azobenzene unit between a hydrophobic trans- and 4 hydrophilic cis-conformation, as characterized by dynamic light scattering and AFM measurements. In contrast to other molecular Species used for invasive DNA compaction, such as-widely used azobenzene containing cationic surfactant (Azo-TAR, C-4-Azo-OCX-TMAB), the presented peptidomimetic agent appears to lead to different compleication/compaction mechanisms., An investigation of Ato-PM in close proximity to a DNA segment by means of a molecular dynamics simulation sustains a picture in which Azo-PM acts as a multivalent counterion, with its rather large cationic oligo(amidoamine) backbone dominating the interaction with the double helix, fine-tuned or assisted by the presence" andisomerization state of the Azo-moiety. However, due to its peptidomimetic backbone, Azo-PM should be far less toxic than photosensitive surfactants and might represent a starting point for a conscious design of photoswitchable, biocompatible vectors for gene delivery.
Brodeur, Abel ; Mikola, Derek ; Cook, Nikolai ; Brailey, Thomas ; Briggs, Ryan ; Gendre, Alexandra de ; Dupraz, Yannick ; Fiala, Lenka ; Gabani, Jacopo ; Gauriot, Romain ; Haddad, Joanne ; Lima, Goncalo ; Ankel-Peters, Jörg ; Dreber, Anna ; Campbell, Douglas ; Kattan, Lamis ; Fages, Diego Marino ; Mierisch, Fabian ; Sun, Pu ; Wright, Taylor ; Connolly, Marie ; Hoces de la Guardia, Fernando ; Johannesson, Magnus ; Miguel, Edward ; Vilhuber, Lars ; Abarca, Alejandro ; Acharya, Mahesh ; Adjisse, Sossou Simplice ; Akhtar, Ahwaz ; Lizardi, Eduardo Alberto Ramirez ; Albrecht, Sabina ; Andersen, Synve Nygaard ; Andlib, Zubaria ; Arrora, Falak ; Ash, Thomas ; Bacher, Etienne ; Bachler, Sebastian ; Bacon, Félix ; Bagues, Manuel ; Balogh, Timea ; Batmanov, Alisher ; Barschkett, Mara ; Basdil, B. Kaan ; Dower, Jaromneda ; Castek, Ondrej ; Caviglia-Harris, Jill ; Strand, Gabriella Chauca ; Chen, Shi ; Chzhen, Asya ; Chung, Jong ; Collins, Jason ; Coppock, Alexander ; Cordeau, Hugo ; Couillard, Ben ; Crechet, Jonathan ; Crippa, Lorenzo ; Cui, Jeanne ; Czymara, Christian ; Daarstad, Haley ; Dao, Danh Chi ; Dao, Dong ; Schmandt, Marco David ; Linde, Astrid de ; Melo, Lucas De ; Deer, Lachlan ; Vera, Micole De ; Dimitrova, Velichka ; Dollbaum, Jan Fabian ; Dollbaum, Jan Matti ; Donnelly, Michael ; Huynh, Luu Duc Toan ; Dumbalska, Tsvetomira ; Duncan, Jamie ; Duong, Kiet Tuan ; Duprey, Thibaut ; Dworschak, Christoph ; Ellingsrud, Sigmund ; Elminejad, Ali ; Eissa, Yasmine ; Erhart, Andrea ; Etingin-Frati, Giulian ; Fatemi-Pour, Elaheh ; Federice, Alexa ; Feld, Jan ; Fenig, Guidon ; Firouzjaeiangalougah, Mojtaba ; Fleisje, Erlend ; Fortier-Chouinard, Alexandre ; Engel, Julia Francesca ; Fries, Tilman ; Fortier, Reid ; Fréchet, Nadjim ; Galipeau, Thomas ; Gallegos, Sebastián ; Gangji, Areez ; Gao, Xiaoying ; Garnache, Cloé ; Gáspár, Attila ; Gavrilova, Evelina ; Ghosh, Arijit ; Gibney, Garreth ; Gibson, Grant ; Godager, Geir ; Goff, Leonard ; Gong, Da ; González, Javier ; Gretton, Jeremy ; Griffa, Cristina ; Grigoryeva, Idaliya ; Grtting, Maja ; Guntermann, Eric ; Guo, Jiaqi ; Gugushvili, Alexi ; Habibnia, Hooman ; Häffner, Sonja ; Hall, Jonathan D. ; Hammar, Olle ; Kordt, Amund Hanson ; Hashimoto, Barry ; Hartley, Jonathan S. ; Hausladen, Carina I. ; Havránek, Tomáš ; Hazen, Jacob ; He, Harry ; Hepplewhite, Matthew ; Herrera-Rodriguez, Mario ; Heuer, Felix ; Heyes, Anthony ; Ho, Anson T. Y. ; Holmes, Jonathan ; Holzknecht, Armando ; Hsu, Yu-Hsiang Dexter ; Hu, Shiang-Hung ; Huang, Yu-Shiuan ; Huebener, Mathias ; Huber, Christoph ; Huynh, Kim P. ; Irsova, Zuzana ; Isler, Ozan ; Jakobsson, Niklas ; Frith, Michael James ; Jananji, Raphaël ; Jayalath, Tharaka A. ; Jetter, Michael ; John, Jenny ; Forshaw, Rachel Joy ; Juan, Felipe ; Kadriu, Valon ; Karim, Sunny ; Kelly, Edmund ; Dang, Duy Khanh Hoang ; Khushboo, Tazia ; Kim, Jin ; Kjellsson, Gustav ; Kjelsrud, Anders ; Kotsadam, Andreas ; Korpershoek, Jori ; Krashinsky, Lewis ; Kundu, Suranjana ; Kustov, Alexander ; Lalayev, Nurlan ; Langlois, Audrée ; Laufer, Jill ; Lee-Whiting, Blake ; Leibing, Andreas ; Lenz, Gabriel ; Levin, Joel ; Li, Peng ; Li, Tongzhe ; Lin, Yuchen ; Listo, Ariel ; Liu, Dan ; Lu, Xuewen ; Lukmanova, Elvina ; Luscombe, Alex ; Lusher, Lester R. ; Lyu, Ke ; Ma, Hai ; Mäder, Nicolas ; Makate, Clifton ; Malmberg, Alice ; Maitra, Adit ; Mandas, Marco ; Marcus, Jan ; Margaryan, Shushanik ; Márk, Lili ; Martignano, Andres ; Marsh, Abigail ; Masetto, Isabella ; McCanny, Anthony ; McManus, Emma ; McWay, Ryan ; Metson, Lennard ; Kinge, Jonas Minet ; Mishra, Sumit ; Mohnen, Myra ; Möller, Jakob ; Montambeault, Rosalie ; Montpetit, Sébastien ; Morin, Louis-Philippe ; Morris, Todd ; Moser, Scott ; Motoki, Fabio ; Muehlenbachs, Lucija ; Musulan, Andreea ; Musumeci, Marco ; Nabin, Munirul ; Nchare, Karim ; Neubauer, Florian ; Nguyen, Quan M. P. ; Nguyen, Tuan ; Nguyen-Tien, Viet ; Niazi, Ali ; Nikolaishvili, Giorgi ; Nordstrom, Ardyn ; Nü, Patrick ; Odermatt, Angela ; Olson, Matt ; ien, Henning ; Ölkers, Tim ; Vert, Miquel Oliver i. ; Oral, Emre ; Oswald, Christian ; Ousman, Ali ; Özak, Ömer ; Pandey, Shubham ; Pavlov, Alexandre ; Pelli, Martino ; Penheiro, Romeo ; Park, RyuGyung ; Martel, Eva Pérez ; Petrovičová, Tereza ; Phan, Linh ; Prettyman, Alexa ; Procházka, Jakub ; Putri, Aqila ; Quandt, Julian ; Qiu, Kangyu ; Nguyen, Loan Quynh Thi ; Rahman, Andaleeb ; Rea, Carson H. ; Reiremo, Adam ; Renée, Laëtitia ; Richardson, Joseph ; Rivers, Nicholas ; Rodrigues, Bruno ; Roelofs, William ; Roemer, Tobias ; Rogeberg, Ole ; Rose, Julian ; Roskos-Ewoldsen, Andrew ; Rosmer, Paul ; Sabada, Barbara ; Saberian, Soodeh ; Salamanca, Nicolas ; Sator, Georg ; Sawyer, Antoine ; Scates, Daniel ; Schlüter, Elmar ; Sells, Cameron ; Sen, Sharmi ; Sethi, Ritika ; Shcherbiak, Anna ; Sogaolu, Moyosore ; Soosalu, Matt ; Srensen, Erik ; Sovani, Manali ; Spencer, Noah ; Staubli, Stefan ; Stans, Renske ; Stewart, Anya ; Stips, Felix ; Stockley, Kieran ; Strobel, Stephenson ; Struby, Ethan ; Tang, John ; Tanrisever, Idil ; Yang, Thomas Tao ; Tastan, Ipek ; Tatić, Dejan ; Tatlow, Benjamin ; Seuyong, Féraud Tchuisseu ; Thériault, Rémi ; Thivierge, Vincent ; Tian, Wenjie ; Toma, Filip-Mihai ; Totarelli, Maddalena ; Tran, Van-Anh ; Truong, Hung ; Tsoy, Nikita ; Tuzcuoglu, Kerem ; Ubfal, Diego ; Villalobos, Laura ; Walterskirchen, Julian ; Wang, Joseph Taoyi ; Wattal, Vasudha ; Webb, Matthew D. ; Weber, Bryan ; Weisser, Reinhard ; Weng, Wei-Chien ; Westheide, Christian ; White, Kimberly ; Winter, Jacob ; Wochner, Timo ; Woerman, Matt ; Wong, Jared ; Woodard, Ritchie ; Wroński, Marcin ; Yazbeck, Myra ; Yang, Gustav Chung ; Yap, Luther ; Yassin, Kareman ; Ye, Hao ; Yoon, Jin Young ; Yurris, Chris ; Zahra, Tahreen ; Zaneva, Mirela ; Zayat, Aline ; Zhang, Jonathan ; Zhao, Ziwei ; Yaolang, Zhong
This study pushes our understanding of research reliability by reproducing and replicating claims from 110 papers in leading economic and political science journals. The analysis involves computational reproducibility checks and robustness assessments. It reveals several patterns. First, we uncover a high rate of fully computationally reproducible results (over 85%). Second, excluding minor issues like missing packages or broken pathways, we uncover coding errors for about 25% of studies, with some studies containing multiple errors. Third, we test the robustness of the results to 5,511 re-analyses. We find a robustness reproducibility of about 70%. Robustness reproducibility rates are relatively higher for re-analyses that introduce new data and lower for re-analyses that change the sample or the definition of the dependent variable. Fourth, 52% of re-analysis effect size estimates are smaller than the original published estimates and the average statistical significance of a re-analysis is 77% of the original. Lastly, we rely on six teams of researchers working independently to answer eight additional research questions on the determinants of robustness reproducibility. Most teams find a negative relationship between replicators' experience and reproducibility, while finding no relationship between reproducibility and the provision of intermediate or even raw data combined with the necessary cleaning codes.
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