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Förstner, Bernd R. ; Tschorn, Mira ; Reinoso-Schiller, Nicolas ; Maričić, Lea Mascarell ; Röcher, Erik ; Kalman, Janos L. ; Stroth, Sanna ; Mayer, Annalina V. ; Schwarz, Kristina ; Kaiser, Anna ; Pfennig, Andrea ; Manook, André ; Ising, Marcus ; Heinig, Ingmar ; Pittig, Andre ; Heinz, Andreas ; Mathiak, Klaus ; Schulze, Thomas G. ; Schneider, Frank ; Kamp-Becker, Inge ; Meyer-Lindenberg, Andreas ; Padberg, Frank ; Banaschewski, Tobias ; Bauer, Michael ; Rupprecht, Rainer ; Wittchen, Hans-Ulrich ; Rapp, Michael A.
This study aimed to build on the relationship of well-established self-report and behavioral assessments to the latent constructs positive (PVS) and negative valence systems (NVS), cognitive systems (CS), and social processes (SP) of the Research Domain Criteria (RDoC) framework in a large transnosological population which cuts across DSM/ICD-10 disorder criteria categories. One thousand four hundred and thirty one participants (42.1% suffering from anxiety/fear-related, 18.2% from depressive, 7.9% from schizophrenia spectrum, 7.5% from bipolar, 3.4% from autism spectrum, 2.2% from other disorders, 18.4% healthy controls, and 0.2% with no diagnosis specified) recruited in studies within the German research network for mental disorders for the Phenotypic, Diagnostic and Clinical Domain Assessment Network Germany (PD-CAN) were examined with a Mini-RDoC-Assessment including behavioral and self-report measures. The respective data was analyzed with confirmatory factor analysis (CFA) to delineate the underlying latent RDoC-structure. A revised four-factor model reflecting the core domains positive and negative valence systems as well as cognitive systems and social processes showed a good fit across this sample and showed significantly better fit compared to a one factor solution. The connections between the domains PVS, NVS and SP could be substantiated, indicating a universal latent structure spanning across known nosological entities. This study is the first to give an impression on the latent structure and intercorrelations between four core Research Domain Criteria in a transnosological sample. We emphasize the possibility of using already existing and well validated self-report and behavioral measurements to capture aspects of the latent structure informed by the RDoC matrix.
Abramowski, Attila ; Aharonian, Felix A. ; Benkhali, Faical Ait ; Akhperjanian, A. G. ; Angüner, Ekrem Oǧuzhan ; Backes, Michael ; Balenderan, Shangkari ; Balzer, Arnim ; Barnacka, Anna ; Becherini, Yvonne ; Tjus, J. Becker ; Berge, David ; Bernhard, Sabrina ; Bernlöhr, K. ; Birsin, E. ; Biteau, Jonathan ; Boettcher, Markus ; Boisson, Catherine ; Bolmont, J. ; Bordas, Pol ; Bregeon, Johan ; Brun, Francois ; Brun, Pierre ; Bryan, Mark ; Bulik, Tomasz ; Carrigan, Svenja ; Casanova, Sabrina ; Chadwick, Paula M. ; Chakraborty, N. ; Chalme-Calvet, R. ; Chaves, Ryan C. G. ; Chretien, M. ; Colafrancesco, Sergio ; Cologna, Gabriele ; Conrad, Jan ; Couturier, C. ; Cui, Y. ; Davids, I. D. ; Degrange, B. ; Deil, C. ; dewilt, P. ; Djannati-Ataï, A. ; Domainko, W. ; Donath, A. ; Dubus, G. ; Dutson, K. ; Dyks, J. ; Dyrda, M. ; Edwards, T. ; Egberts, Kathrin ; Eger, P. ; Espigat, P. ; Farnier, C. ; Fegan, S. ; Feinstein, F. ; Fernandes, M. V. ; Fernandez, D. ; Fiasson, A. ; Fontaine, G. ; Foerster, A. ; Fuessling, M. ; Gabici, S. ; Gajdus, M. ; Gallant, Y. A. ; Garrigoux, T. ; Giavitto, G. ; Giebels, B. ; Glicenstein, J. F. ; Gottschall, D. ; Grondin, M. -H. ; Grudzinska, M. ; Hadasch, D. ; Haeffner, S. ; Hahn, J. ; Harris, J. ; Heinzelmann, G. ; Henri, G. ; Hermann, G. ; Hervet, O. ; Hillert, A. ; Hinton, James Anthony ; Hofmann, W. ; Hofverberg, P. ; Holler, M. ; Horns, D. ; Ivascenko, A. ; Jacholkowska, A. ; Jahn, C. ; Jamrozy, Marek ; Janiak, M. ; Jankowsky, F. ; Jung-Richardt, I. ; Kastendieck, M. A. ; Katarzynski, Krzysztof ; Katz, Uli ; Kaufmann, S. ; Khelifi, B. ; Kieffer, M. ; Klepser, S. ; Klochkov, D. ; Kluzniak, W. ; Kolitzus, D. ; Komin, Nu. ; Kosack, K. ; Krakau, S. ; Krayzel, F. ; Krueger, P. P. ; Laffon, H. ; Lamanna, G. ; Lefaucheur, J. ; Lefranc, V. ; Lemiere, A. ; Lemoine-Goumard, M. ; Lenain, J. -P. ; Lohse, T. ; Lopatin, A. ; Lu, C. -C. ; Marandon, V. ; Marcowith, Alexandre ; Marx, R. ; Maurin, G. ; Maxted, N. ; Mayer, M. ; McComb, T. J. L. ; Mehault, J. ; Meintjes, P. J. ; Menzler, U. ; Meyer, M. ; Mitchell, A. M. W. ; Moderski, R. ; Mohamed, M. ; Mora, K. ; Moulin, Emmanuel ; Murach, T. ; de Naurois, M. ; Niemiec, J. ; Nolan, S. J. ; Oakes, L. ; Odaka, H. ; Ohm, S. ; Opitz, B. ; Ostrowski, M. ; Oya, I. ; Panter, M. ; Parsons, R. D. ; Arribas, M. Paz ; Pekeur, N. W. ; Pelletier, G. ; Petrucci, P. -O. ; Peyaud, B. ; Pita, S. ; Poon, H. ; Puehlhofer, G. ; Punch, Michael ; Quirrenbach, A. ; Raab, S. ; Reichardt, I. ; Reimer, A. ; Reimer, Olaf ; Renaud, M. ; de los Reyes, R. ; Rieger, F. ; Romoli, C. ; Rosier-Lees, S. ; Rowell, G. ; Rudak, B. ; Rulten, C. B. ; Sahakian, V. ; Salek, D. ; Sanchez, David M. ; Santangelo, Andrea ; Schlickeiser, R. ; Schuessler, Fabian ; Schulz, A. ; Schwanke, U. ; Schwarzburg, S. ; Schwemmer, S. ; Sol, H. ; Spanier, F. ; Spengler, G. ; Spies, F. ; Stawarz, L. ; Steenkamp, R. ; Stegmann, Christian ; Stinzing, F. ; Stycz, K. ; Sushch, Iurii ; Tavernet, J. -P. ; Tavernier, T. ; Taylor, A. M. ; Terrier, R. ; Tluczykont, M. ; Trichard, C. ; Valerius, K. ; van Eldik, Christopher ; van Soelen, B. ; Vasileiadis, G. ; Veh, J. ; Venter, C. ; Viana, A. ; Vincent, P. ; Vink, J. ; Voelk, H. J. ; Volpe, F. ; Vorster, M. ; Vuillaume, T. ; Wagner, S. J. ; Wagner, P. ; Wagner, R. M. ; Ward, M. ; Weidinger, M. ; Weitzel, Q. ; White, R. ; Wierzcholska, A. ; Willmann, P. ; Woernlein, A. ; Wouters, D. ; Yang, R. ; Zabalza, V. ; Zaborov, D. ; Zacharias, M. ; Zdziarski, A. A. ; Zech, Alraune ; Zechlin, H. -S. ; Fukui, Y.
Diffuse gamma-ray emission is the most prominent observable signature of celestial cosmic-ray interactions at high energies. While already being investigated at GeVenergies over several decades, assessments of diffuse gamma-ray emission at TeVenergies remain sparse. After completion of the systematic survey of the inner Galaxy, the H.E.S.S. experiment is in a prime position to observe large-scale diffuse emission at TeVenergies. Data of the H.E.S.S. Galactic Plane Survey are investigated in regions off known gamma-ray sources. Corresponding gamma-ray flux measurements were made over an extensive grid of celestial locations. Longitudinal and latitudinal profiles of the observed gamma-ray fluxes show characteristic excess emission not attributable to known gamma-ray sources. For the first time large-scale gamma-ray emission along the Galactic plane using imaging atmospheric Cherenkov telescopes has been observed. While the background subtraction technique limits the ability to recover modest variation on the scale of the H.E.S.S. field of view or larger, which is characteristic of the inverse Compton scatter-induced Galactic diffuse emission, contributions of neutral pion decay as well as emission from unresolved gamma-ray sources can be recovered in the observed signal to a large fraction. Calculations show that the minimum gamma-ray emission from pi(0) decay represents a significant contribution to the total signal. This detection is interpreted as a mix of diffuse Galactic gamma-ray emission and unresolved sources.
Abramowski, Attila ; Aharonian, Felix A. ; Benkhali, Faical Ait ; Akhperjanian, A. G. ; Angüner, Ekrem Oǧuzhan ; Backes, Michael ; Balenderan, Shangkari ; Balzer, Arnim ; Barnacka, Anna ; Becherini, Yvonne ; Tjus, J. Becker ; Berge, David ; Bernhard, Sabrina ; Bernlöhr, K. ; Birsin, E. ; Biteau, Jonathan ; Boettcher, Markus ; Boisson, Catherine ; Bolmont, J. ; Bordas, Pol ; Bregeon, Johan ; Brun, Francois ; Brun, Pierre ; Bryan, Mark ; Bulik, Tomasz ; Carrigan, Svenja ; Casanova, Sabrina ; Chadwick, Paula M. ; Chakraborty, N. ; Chalme-Calvet, R. ; Chaves, Ryan C. G. ; Chretien, M. ; Colafrancesco, Sergio ; Cologna, Gabriele ; Conrad, Jan ; Couturier, C. ; Cui, Y. ; Davids, I. D. ; Degrange, B. ; Deil, C. ; deWilt, P. ; Djannati-Ataï, A. ; Domainko, W. ; Donath, A. ; Dubus, G. ; Dutson, K. ; Dyks, J. ; Dyrda, M. ; Edwards, T. ; Egberts, Kathrin ; Eger, P. ; Espigat, P. ; Farnier, C. ; Fegan, S. ; Feinstein, F. ; Fernandes, M. V. ; Fernandez, D. ; Fiasson, A. ; Fontaine, G. ; Foerster, A. ; Füssling, Matthias ; Gabici, S. ; Gajdus, M. ; Gallant, Y. A. ; Garrigoux, T. ; Giavitto, G. ; Giebels, B. ; Glicenstein, J. F. ; Gottschall, D. ; Grondin, M. -H. ; Grudzinska, M. ; Hadasch, D. ; Haeffner, S. ; Hahn, J. ; Harris, J. ; Heinzelmann, G. ; Henri, G. ; Hermann, G. ; Hervet, O. ; Hillert, A. ; Hinton, James Anthony ; Hofmann, W. ; Hofverberg, P. ; Holler, Maraike ; Horns, D. ; Ivascenko, A. ; Jacholkowska, A. ; Jahn, C. ; Jamrozy, M. ; Janiak, M. ; Jankowsky, F. ; Jung-Richardt, I. ; Kastendieck, M. A. ; Katarzynski, K. ; Katz, U. ; Kaufmann, S. ; Khelifi, B. ; Kieffer, M. ; Klepser, S. ; Klochkov, D. ; Kluzniak, W. ; Kolitzus, D. ; Komin, Nu. ; Kosack, K. ; Krakau, S. ; Krayzel, F. ; Krueger, P. P. ; Laffon, H. ; Lamanna, G. ; Lefaucheur, J. ; Lefranc, V. ; Lemiere, A. ; Lemoine-Goumard, M. ; Lenain, J. -P. ; Lohse, T. ; Lopatin, A. ; Lu, C. -C. ; Marandon, V. ; Marcowith, Alexandre ; Marx, R. ; Maurin, G. ; Maxted, N. ; Mayer, Michael ; McComb, T. J. L. ; Mehault, J. ; Meintjes, P. J. ; Menzler, U. ; Meyer, M. ; Mitchell, A. M. W. ; Moderski, R. ; Mohamed, M. ; Mora, K. ; Moulin, Emmanuel ; Murach, T. ; de Naurois, M. ; Niemiec, J. ; Nolan, S. J. ; Oakes, L. ; Odaka, H. ; Ohm, S. ; Opitz, B. ; Ostrowski, M. ; Oya, I. ; Panter, M. ; Parsons, R. D. ; Arribas, M. Paz ; Pekeur, N. W. ; Pelletier, G. ; Petrucci, P. -O ; Peyaud, B. ; Pita, S. ; Poon, H. ; Puehlhofer, G. ; Punch, M. ; Quirrenbach, A. ; Raab, S. ; Reichardt, I. ; Reimer, A. ; Reimer, O. ; Renaud, M. ; de los Reyes, R. ; Rieger, F. ; Romoli, C. ; Rosier-Lees, S. ; Rowell, G. ; Rudak, B. ; Rulten, C. B. ; Sahakian, V. ; Salek, D. ; Sanchez, David M. ; Santangelo, Andrea ; Schlickeiser, R. ; Schuessler, F. ; Schulz, A. ; Schwanke, U. ; Schwarzburg, S. ; Schwemmer, S. ; Sol, H. ; Spanier, F. ; Spengler, G. ; Spies, F. ; Stawarz, L. ; Steenkamp, R. ; Stegmann, Christian ; Stinzing, F. ; Stycz, K. ; Sushch, Iurii ; Tavernet, J. -P. ; Tavernier, T. ; Taylor, A. M. ; Terrier, R. ; Tluczykont, M. ; Trichard, C. ; Valerius, K. ; van Eldik, C. ; van Soelen, B. ; Vasileiadis, G. ; Veh, J. ; Venter, C. ; Viana, A. ; Vincent, P. ; Vink, J. ; Voelk, H. J. ; Volpe, F. ; Vorster, M. ; Vuillaume, T. ; Wagner, S. J. ; Wagner, P. ; Wagner, R. M. ; Ward, M. ; Weidinger, M. ; Weitzel, Q. ; White, R. ; Wierzcholska, A. ; Willmann, P. ; Woernlein, A. ; Wouters, D. ; Yang, R. ; Zabalza, V. ; Zaborov, D. ; Zacharias, M. ; Zdziarski, A. A. ; Zech, Alraune ; Zechlin, H. -S.
Context. Puppis A is an interesting similar to 4 kyr-old supernova remnant (SNR) that shows strong evidence of interaction between the forward shock and a molecular cloud. It has been studied in detail from radio frequencies to high-energy (HE, 0.1-100 GeV) gamma-rays. An analysis of the Fermi-LAT data has shown extended HE gamma-ray emission with a 0.2-100 GeV spectrum exhibiting no significant deviation from a power law, unlike most of the GeV-emitting SNRs known to be interacting with molecular clouds. This makes it a promising target for imaging atmospheric Cherenkov telescopes (IACTs) to probe the gamma-ray emission above 100 GeV.
Aims. Very-high-energy (VHE, E >= 0.1 TeV) gamma-ray emission from Puppis A has been, for the first time, searched for with the High Energy Stereoscopic System (HESS.).
Methods. Stereoscopic imaging of Cherenkov radiation from extensive air showers is used to reconstruct the direction and energy of the incident gamma-rays in order to produce sky images and source spectra. The profile likelihood method is applied to find constraints on the existence of a potential break or cutoff in the photon spectrum.
Results. The analysis of the HESS. data does not reveal any significant emission towards Puppis A. The derived upper limits on the differential photon flux imply that its broadband gamma-ray spectrum must exhibit a spectral break or cutoff. By combining Fermi-LAT and HESS. measurements, the 99% confidence-level upper limits on such a cutoff are found to be 450 and 280 GeV, assuming a power law with a simple exponential and a sub-exponential cutoff, respectively. It is concluded that none of the standard limitations (age, size, radiative losses) on the particle acceleration mechanism, assumed to be continuing at present, can explain the lack of VHE signal. The scenario in which particle acceleration has ceased some time ago is considered as an alternative explanation. The HE/VHE spectrum of Puppis A could then exhibit a break of non-radiative origin (as observed in several other interacting SNRs, albeit at somewhat higher energies), owing to the interaction with dense and neutral material, in particular towards the NE region.
Abdalla, Hassan E. ; Abramowski, Attila ; Aharonian, Felix A. ; Benkhali, Faical Ait ; Akhperjanian, A. G. ; Andersson, T. ; Angüner, Ekrem Oǧuzhan ; Arrieta, M. ; Aubert, Pierre ; Backes, Michael ; Balzer, Arnim ; Barnard, Michelle ; Becherini, Yvonne ; Tjus, J. Becker ; Berge, David ; Bernhard, Sabrina ; Bernlöhr, K. ; Birsin, E. ; Blackwell, R. ; Boettcher, Markus ; Boisson, Catherine ; Bolmont, J. ; Bordas, Pol ; Bregeon, Johan ; Brun, Francois ; Brun, Pierre ; Bryan, Mark ; Bulik, Tomasz ; Capasso, M. ; Carr, John ; Casanova, Sabrina ; Chakraborty, N. ; Chalme-Calvet, R. ; Chaves, Ryan C. G. ; Chen, Andrew ; Chevalier, J. ; Chretien, M. ; Colafrancesco, Sergio ; Cologna, Gabriele ; Condon, B. ; Conrad, Jan ; Couturier, C. ; Cui, Y. ; Davids, I. D. ; Degrange, B. ; Deil, C. ; Devin, J. ; de Wilt, P. ; Djannati-Ataie, A. ; Domainko, W. ; Donath, A. ; Dubus, G. ; Dutson, K. ; Dyks, J. ; Dyrda, M. ; Edwards, T. ; Egberts, Kathrin ; Eger, P. ; Ernenwein, J. -P. ; Eschbach, S. ; Farnier, C. ; Fegan, S. ; Fernandes, M. V. ; Fiasson, A. ; Fontaine, G. ; Foerster, A. ; Funk, S. ; Fuessling, M. ; Gabici, S. ; Gajdus, M. ; Gallant, Y. A. ; Garrigoux, T. ; Giavitto, G. ; Giebels, B. ; Glicenstein, J. F. ; Gottschall, D. ; Goyal, A. ; Grondin, M. -H. ; Grudzinska, M. ; Hadasch, D. ; Hahn, J. ; Hawkes, J. ; Heinzelmann, G. ; Henri, G. ; Hermann, G. ; Hervet, O. ; Hillert, A. ; Hinton, James Anthony ; Hofmann, W. ; Hoischen, Clemens ; Holler, M. ; Horns, D. ; Ivascenko, A. ; Jacholkowska, A. ; Jamrozy, M. ; Janiak, M. ; Jankowsky, D. ; Jankowsky, F. ; Jingo, M. ; Jogler, T. ; Jouvin, L. ; Jung-Richardt, I. ; Kastendieck, M. A. ; Katarzynski, K. ; Katz, U. ; Kerszberg, D. ; Khelifi, B. ; Kieffer, M. ; King, J. ; Klepser, S. ; Klochkov, D. ; Kluzniak, W. ; Kolitzus, D. ; Komin, Nu. ; Kosack, K. ; Krakau, S. ; Kraus, M. ; Krayzel, F. ; Krueger, P. P. ; Laffon, H. ; Lamanna, G. ; Lau, J. ; Lees, J. -P. ; Lefaucheur, J. ; Lefranc, V. ; Lemiere, A. ; Lemoine-Goumard, M. ; Lenain, J. -P. ; Leser, Eva ; Liu, R. ; Lohse, T. ; Lorentz, M. ; Lypova, I. ; Marandon, V. ; Marcowith, Alexandre ; Mariaud, C. ; Marx, R. ; Maurin, G. ; Maxted, N. ; Mayer, Michael ; Meintjes, P. J. ; Meyer, M. ; Mitchell, A. M. W. ; Moderski, R. ; Mohamed, M. ; Mora, K. ; Moulin, Emmanuel ; Murach, T. ; de Naurois, M. ; Niederwanger, F. ; Niemiec, J. ; Oakes, L. ; Odaka, H. ; Ohm, S. ; Ostrowski, M. ; Oettl, S. ; Oya, I. ; Padovani, M. ; Panter, M. ; Parsons, R. D. ; Arribas, M. Paz ; Pekeur, N. W. ; Pelletier, G. ; Perennes, C. ; Petrucci, P. -O. ; Peyaud, B. ; Pita, S. ; Poon, H. ; Prokhorov, D. ; Prokoph, H. ; Puehlhofer, G. ; Punch, M. ; Quirrenbach, A. ; Raab, S. ; Reimer, A. ; Reimer, O. ; Renaud, M. ; Reyes, R. de los ; Rieger, F. ; Romoli, C. ; Rosier-Lees, S. ; Rowell, G. ; Rudak, B. ; Rulten, C. B. ; Sahakian, V. ; Salek, D. ; Sanchez, David M. ; Santangelo, Andrea ; Sasaki, M. ; Schlickeiser, R. ; Schuessler, F. ; Schulz, A. ; Schwanke, U. ; Schwemmer, S. ; Settimo, M. ; Seyffert, A. S. ; Shafi, N. ; Shilon, I. ; Simoni, R. ; Sol, H. ; Spanier, F. ; Spengler, G. ; Spies, F. ; Stawarz, L. ; Steenkamp, R. ; Stegmann, Christian ; Stinzing, F. ; Stycz, K. ; Sushch, Iurii ; Tavernet, J. -P. ; Tavernier, T. ; Taylor, A. M. ; Terrier, R. ; Tibaldo, L. ; Tluczykont, M. ; Trichard, C. ; Tuffs, R. ; van der Walt, J. ; van Eldik, C. ; van Soelen, B. ; Vasileiadis, G. ; Veh, J. ; Venter, C. ; Viana, A. ; Vincent, P. ; Vink, J. ; Voisin, F. ; Voelk, H. J. ; Vuillaume, T. ; Wadiasingh, Z. ; Wagner, S. J. ; Wagner, P. ; Wagner, R. M. ; White, R. ; Wierzcholska, A. ; Willmann, P. ; Woernlein, A. ; Wouters, D. ; Yang, R. ; Zabalza, V. ; Zaborov, D. ; Zacharias, M. ; Zdziarski, A. A. ; Zech, Alraune ; Zefi, F. ; Ziegler, A. ; Zywucka, N.
A search for dark matter linelike signals iss performed in the vicinity of the Galactic Center by the H.E.S.S. experiment on observational data taken in 2014. An unbinned likelihood analysis iss developed to improve the sensitivity to linelike signals. The upgraded analysis along with newer data extend the energy coverage of the previous measurement down to 100 GeV. The 18 h of data collected with the H.E.S.S. array allow one to rule out at 95% C.L. the presence of a 130 GeV line (at l = -1.5 degrees, b = 0 degrees and for a dark matter profile centered at this location) previously reported in Fermi-LAT data. This new analysis overlaps significantly in energy with previous Fermi-LAT and H.E.S.S. results. No significant excess associated with dark matter annihilations was found in the energy range of 100 GeV to 2 TeV and upper limits on the gamma-ray flux and the velocity weighted annihilation cross section are derived adopting an Einasto dark matter halo profile. Expected limits for present and future large statistics H.E.S.S. observations are also given.
Aichert, Ingrid ; Staiger, Anja ; Schulte-Mäter, Anne ; Becker-Redding, Ulrike ; Stahn, Corinna ; Peschke, Claudia ; Heide, Judith ; Ott, Susan ; Herrmann, Heike ; Völsch, Juliane ; Mayer, Jörg ; Rohnke, Lucie ; Frank, Ulrike ; Stadie, Nicole ; Jentsch, Nadine ; Blech, Anke ; Kurtenbach, Stephanie ; Thieke, Johanna ; Schröder, Astrid ; Stahn, Corinna ; Hörnig, Robin ; Burchert, Frank ; De Bleser, Ria ; Heister, Julian ; Bartels, Luise ; Würzner, Kay-Michael ; Böhme, Romy ; Burmester, Juliane ; Krajewski, Melanie ; Nager, Wido ; Jungehülsing, Gerhard Jan ; Wartenburger, Isabell ; Jöbges, Michael ; Schwilling, Eleonore ; Lidzba, Karen ; Winkler, Susanne ; Konietzko, Andreas ; Krägeloh-Mann, Ingeborg ; Rilling, Eva ; Wilken, Rainer ; Wismann, Kathrin ; Glandorf, Birte ; Hoffmann, Hannah ; Hinnenkamp, Christiane ; Rohlmann, Insa ; Ludewigt, Jacqueline ; Bittner, Christian ; Orlov, Tatjana ; Claus, Katrin ; Ehemann, Christine ; Winnecken, Andreas ; Hummel, Katja ; Breitenstein, Sarah
Das 3. Herbsttreffen Patholinguistik fand am 21. November 2009 an der Universität Potsdam statt. Der vorliegende Tagungsband enthält die drei Hauptvorträge zum Schwerpunktthema „Von der Programmierung zu Artikulation: Sprechapraxie bei Kindern und Erwachsenen“. Darüber hinaus enthält der Band die Beiträge aus dem Spektrum Patholinguistik, sowie die Abstracts der Posterpräsentationen.
Stinnesbeck, Wolfgang ; Becker, Julia ; Hering, Fabio ; Frey, Eberhard ; Gonzalez Gonzalez, Arturo ; Fohlmeister, Jens Bernd ; Stinnesbeck, Sarah ; Frank, Norbert ; Terrazas Mata, Alejandro ; Elena Benavente, Martha ; Aviles Olguin, Jeronimo ; Aceves Nunez, Eugenio ; Zell, Patrick ; Deininger, Michael
Preceramic human skeletal remains preserved in submerged caves near Tulum in the Mexican state of Quintana Roo, Mexico, reveal conflicting results regarding C-14 dating. Here we use U-series techniques for dating a stalagmite overgrowing the pelvis of a human skeleton discovered in the submerged Chan Hol cave. The oldest closed system U/Th age comes from around 21 mm above the pelvis defining the terminus ante quem for the pelvis to 11311 +/- 370 y BP. However, the skeleton might be considerable older, probably as old as 13 ky BP as indicated by the speleothem stable isotope data. The Chan Hol individual confirms a late Pleistocene settling of Mesoamerica and represents one of the oldest human osteological remains in America.
Becker, Katrin Anne ; Riethmueller, Joachim ; Seitz, Aaron P. ; Gardner, Aaron ; Boudreau, Ryan ; Kamler, Markus ; Kleuser, Burkhard ; Schuchman, Edward ; Caldwell, Charles C. ; Edwards, Michael J. ; Grassme, Heike ; Brodlie, Malcolm ; Gulbins, Erich
Studies over the past several years have demonstrated the important role of sphingolipids in cystic fibrosis (CF), chronic obstructive pulmonary disease and acute lung injury. Ceramide is increased in airway epithelial cells and alveolar macrophages of CF mice and humans, while sphingosine is dramatically decreased. This increase in ceramide results in chronic inflammation, increased death of epithelial cells, release of DNA into the bronchial lumen and thereby an impairment of mucociliary clearance; while the lack of sphingosine in airway epithelial cells causes high infection susceptibility in CF mice and possibly patients. The increase in ceramide mediates an ectopic expression of beta 1-integrins in the luminal membrane of CF epithelial cells, which results, via an unknown mechanism, in a down-regulation of acid ceramidase. It is predominantly this down-regulation of acid ceramidase that results in the imbalance of ceramide and sphingosine in CF cells. Correction of ceramide and sphingosine levels can be achieved by inhalation of functional acid sphingomyelinase inhibitors, recombinant acid ceramidase or by normalization of beta 1-integrin expression and subsequent re-expression of endogenous acid ceramidase. These treatments correct pulmonary inflammation and prevent or treat, respectively, acute and chronic pulmonary infections in CF mice with Staphylococcus aureus and mucoid or non-mucoid Pseudomonas aeruginosa. Inhalation of sphingosine corrects sphingosine levels only and seems to mainly act against the infection. Many antidepressants are functional inhibitors of the acid sphingomyelinase and were designed for systemic treatment of major depression. These drugs could be repurposed to treat CF by inhalation.
Fang, Liang ; Gould, Oliver E. C. ; Lysyakova, Liudmila ; Jiang, Yi ; Sauter, Tilman ; Frank, Oliver ; Becker, Tino ; Schossig, Michael ; Kratz, Karl ; Lendlein, Andreas
The implementation of shape-memory effects (SME) in polymeric micro- or nano-objects currently relies on the application of indirect macroscopic manipulation techniques, for example, stretchable molds or phantoms, to ensembles of small objects. Here, we introduce a method capable of the controlled manipulation and SME quantification of individual micro- and nano-objects in analogy to macroscopic thermomechanical test procedures. An atomic force microscope was utilized to address individual electro-spun poly(ether urethane) (PEU) micro- or nanowires freely suspended between two micropillars on a micro-structured silicon substrate. In this way, programming strains of 10 +/- 1% or 21 +/- 1% were realized, which could be successfully fixed. An almost complete restoration of the original free-suspended shape during heating confirmed the excellent shape-memory performance of the PEU wires. Apparent recovery stresses of sigma(max,app)=1.2 +/- 0.1 and 33.3 +/- 0.1MPa were obtained for a single microwire and nanowire, respectively. The universal AFM test platform described here enables the implementation and quantification of a thermomechanically induced function for individual polymeric micro- and nanosystems.
Personality is a relevant predictor for important life outcomes across the entire lifespan. Although previous studies have suggested the comparability of the measurement of the Big Five personality traits across adulthood, the generalizability to childhood is largely unknown. The present study investigated the structure of the Big Five personality traits assessed with the Big Five Inventory-SOEP Version (BFI-S; SOEP = Socio-Economic Panel) across a broad age range spanning 11-84 years. We used two samples of N = 1,090 children (52% female, M-age = 11.87) and N = 18,789 adults (53% female, M-age = 51.09), estimating a multigroup CFA analysis across four age groups (late childhood: 11-14 years; early adulthood: 17-30 years; middle adulthood: 31-60 years; late adulthood: 61-84 years). Our results indicated the comparability of the personality trait metric in terms of general factor structure, loading patterns, and the majority of intercepts across all age groups. Therefore, the findings suggest both a reliable assessment of the Big Five personality traits with the BFI-S even in late childhood and a vastly comparable metric across age groups.