Refine
Has Fulltext
- no (3)
Document Type
- Article (3)
Language
- English (3)
Is part of the Bibliography
- yes (3)
Keywords
- Alpine Fault (1)
- New Zealand (1)
- cataclasite (1)
- mylonite (1)
- scientific drilling (1)
A catalog of genetic loci associated with kidney function from analyses of a million individuals
(2019)
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
During the second phase of the Alpine Fault, Deep Fault Drilling Project (DFDP) in the Whataroa River, South Westland, New Zealand, bedrock was encountered in the DFDP-2B borehole from 238.5–893.2 m Measured Depth (MD). Continuous sampling and meso- to microscale characterisation of whole rock cuttings established that, in sequence, the borehole sampled amphibolite facies, Torlesse Composite Terrane-derived schists, protomylonites and mylonites, terminating 200–400 m above an Alpine Fault Principal Slip Zone (PSZ) with a maximum dip of 62°. The most diagnostic structural features of increasing PSZ proximity were the occurrence of shear bands and reduction in mean quartz grain sizes. A change in composition to greater mica:quartz + feldspar, most markedly below c. 700 m MD, is inferred to result from either heterogeneous sampling or a change in lithology related to alteration. Major oxide variations suggest the fault-proximal Alpine Fault alteration zone, as previously defined in DFDP-1 core, was not sampled.
Since the adoption of the Paris Agreement, the focus of the United Nations climate regime has shifted from forging consensus among national governments toward animating implementation activity across multiple levels.
Based on a case study of the Global Climate Action Portal-an online database designed to document nonstate actor climate commitments and implementation efforts-we trace, conceptualize, and assess how the roles of data, data infrastructures, and actor constellations have changed as a result of this shift.
We argue that in the pre-COP21 negotiation phase, the United Nations Climate Secretariat strategically used the database to orchestrate and leverage nonstate actor commitments to exert pressure on intergovernmental negotiations.
By contrast, in the post-COP21 implementation phase, the Secretariat, in collaboration with climate data specialists, is seeking to develop the portal to track and animate implementation activity.
Given these developments, we discuss the potential and limitations of data-driven climate governance and set out avenues for future research.