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Year of publication
Is part of the Bibliography
- yes (69)
Keywords
- gamma rays: general (20)
- ISM: supernova remnants (15)
- radiation mechanisms: non-thermal (14)
- cosmic rays (9)
- galaxies: active (9)
- gamma rays: galaxies (8)
- ISM: clouds (6)
- acceleration of particles (6)
- gamma rays: ISM (5)
- astroparticle physics (4)
Abramowski, Attila ; Aharonian, Felix A. ; Benkhali, Faical Ait ; Akhperjanian, A. G. ; Angüner, Ekrem Oǧuzhan ; Backes, Michael ; Balenderan, Shangkari ; Balzer, Arnim ; Barnacka, Anna ; Becherini, Yvonne ; Tjus, J. Becker ; Berge, David ; Bernhard, Sabrina ; Bernlöhr, K. ; Birsin, E. ; Biteau, Jonathan ; Boettcher, Markus ; Boisson, Catherine ; Bolmont, J. ; Bordas, Pol ; Bregeon, Johan ; Brun, Francois ; Brun, Pierre ; Bryan, Mark ; Bulik, Tomasz ; Carrigan, Svenja ; Casanova, Sabrina ; Chadwick, Paula M. ; Chakraborty, N. ; Chalme-Calvet, R. ; Chaves, Ryan C. G. ; Chretien, M. ; Colafrancesco, Sergio ; Cologna, Gabriele ; Conrad, Jan ; Couturier, C. ; Cui, Y. ; Davids, I. D. ; Degrange, B. ; Deil, C. ; dewilt, P. ; Djannati-Ataï, A. ; Domainko, W. ; Donath, A. ; Dubus, G. ; Dutson, K. ; Dyks, J. ; Dyrda, M. ; Edwards, T. ; Egberts, Kathrin ; Eger, P. ; Espigat, P. ; Farnier, C. ; Fegan, S. ; Feinstein, F. ; Fernandes, M. V. ; Fernandez, D. ; Fiasson, A. ; Fontaine, G. ; Foerster, A. ; Fuessling, M. ; Gabici, S. ; Gajdus, M. ; Gallant, Y. A. ; Garrigoux, T. ; Giavitto, G. ; Giebels, B. ; Glicenstein, J. F. ; Gottschall, D. ; Grondin, M. -H. ; Grudzinska, M. ; Hadasch, D. ; Haeffner, S. ; Hahn, J. ; Harris, J. ; Heinzelmann, G. ; Henri, G. ; Hermann, G. ; Hervet, O. ; Hillert, A. ; Hinton, James Anthony ; Hofmann, W. ; Hofverberg, P. ; Holler, M. ; Horns, D. ; Ivascenko, A. ; Jacholkowska, A. ; Jahn, C. ; Jamrozy, Marek ; Janiak, M. ; Jankowsky, F. ; Jung-Richardt, I. ; Kastendieck, M. A. ; Katarzynski, Krzysztof ; Katz, Uli ; Kaufmann, S. ; Khelifi, B. ; Kieffer, M. ; Klepser, S. ; Klochkov, D. ; Kluzniak, W. ; Kolitzus, D. ; Komin, Nu. ; Kosack, K. ; Krakau, S. ; Krayzel, F. ; Krueger, P. P. ; Laffon, H. ; Lamanna, G. ; Lefaucheur, J. ; Lefranc, V. ; Lemiere, A. ; Lemoine-Goumard, M. ; Lenain, J. -P. ; Lohse, T. ; Lopatin, A. ; Lu, C. -C. ; Marandon, V. ; Marcowith, Alexandre ; Marx, R. ; Maurin, G. ; Maxted, N. ; Mayer, M. ; McComb, T. J. L. ; Mehault, J. ; Meintjes, P. J. ; Menzler, U. ; Meyer, M. ; Mitchell, A. M. W. ; Moderski, R. ; Mohamed, M. ; Mora, K. ; Moulin, Emmanuel ; Murach, T. ; de Naurois, M. ; Niemiec, J. ; Nolan, S. J. ; Oakes, L. ; Odaka, H. ; Ohm, S. ; Opitz, B. ; Ostrowski, M. ; Oya, I. ; Panter, M. ; Parsons, R. D. ; Arribas, M. Paz ; Pekeur, N. W. ; Pelletier, G. ; Petrucci, P. -O. ; Peyaud, B. ; Pita, S. ; Poon, H. ; Puehlhofer, G. ; Punch, Michael ; Quirrenbach, A. ; Raab, S. ; Reichardt, I. ; Reimer, A. ; Reimer, Olaf ; Renaud, M. ; de los Reyes, R. ; Rieger, F. ; Romoli, C. ; Rosier-Lees, S. ; Rowell, G. ; Rudak, B. ; Rulten, C. B. ; Sahakian, V. ; Salek, D. ; Sanchez, David M. ; Santangelo, Andrea ; Schlickeiser, R. ; Schuessler, Fabian ; Schulz, A. ; Schwanke, U. ; Schwarzburg, S. ; Schwemmer, S. ; Sol, H. ; Spanier, F. ; Spengler, G. ; Spies, F. ; Stawarz, L. ; Steenkamp, R. ; Stegmann, Christian ; Stinzing, F. ; Stycz, K. ; Sushch, Iurii ; Tavernet, J. -P. ; Tavernier, T. ; Taylor, A. M. ; Terrier, R. ; Tluczykont, M. ; Trichard, C. ; Valerius, K. ; van Eldik, Christopher ; van Soelen, B. ; Vasileiadis, G. ; Veh, J. ; Venter, C. ; Viana, A. ; Vincent, P. ; Vink, J. ; Voelk, H. J. ; Volpe, F. ; Vorster, M. ; Vuillaume, T. ; Wagner, S. J. ; Wagner, P. ; Wagner, R. M. ; Ward, M. ; Weidinger, M. ; Weitzel, Q. ; White, R. ; Wierzcholska, A. ; Willmann, P. ; Woernlein, A. ; Wouters, D. ; Yang, R. ; Zabalza, V. ; Zaborov, D. ; Zacharias, M. ; Zdziarski, A. A. ; Zech, Alraune ; Zechlin, H. -S. ; Fukui, Y.
Diffuse gamma-ray emission is the most prominent observable signature of celestial cosmic-ray interactions at high energies. While already being investigated at GeVenergies over several decades, assessments of diffuse gamma-ray emission at TeVenergies remain sparse. After completion of the systematic survey of the inner Galaxy, the H.E.S.S. experiment is in a prime position to observe large-scale diffuse emission at TeVenergies. Data of the H.E.S.S. Galactic Plane Survey are investigated in regions off known gamma-ray sources. Corresponding gamma-ray flux measurements were made over an extensive grid of celestial locations. Longitudinal and latitudinal profiles of the observed gamma-ray fluxes show characteristic excess emission not attributable to known gamma-ray sources. For the first time large-scale gamma-ray emission along the Galactic plane using imaging atmospheric Cherenkov telescopes has been observed. While the background subtraction technique limits the ability to recover modest variation on the scale of the H.E.S.S. field of view or larger, which is characteristic of the inverse Compton scatter-induced Galactic diffuse emission, contributions of neutral pion decay as well as emission from unresolved gamma-ray sources can be recovered in the observed signal to a large fraction. Calculations show that the minimum gamma-ray emission from pi(0) decay represents a significant contribution to the total signal. This detection is interpreted as a mix of diffuse Galactic gamma-ray emission and unresolved sources.
Abdalla, Hassan E. ; Abramowski, Attila ; Aharonian, Felix A. ; Benkhali, Faiçal Ait ; Akhperjanian, A. G. ; Angüner, Ekrem Oǧuzhan ; Arrieta, M. ; Aubert, Pierre ; Backes, Michael ; Balzer, Arnim ; Barnard, Michelle ; Becherini, Yvonne ; Tjus, Julia Becker ; Berge, David ; Bernhard, Sabrina ; Bernlöhr, K. ; Birsin, E. ; Blackwell, R. ; Bottcher, Markus ; Boisson, Catherine ; Bolmont, J. ; Bordas, Pol ; Bregeon, Johan ; Brun, Francois ; Brun, Pierre ; Bryan, Mark ; Bulik, Tomasz ; Capasso, M. ; Carr, John ; Casanova, Sabrina ; Chakraborty, N. ; Chalme-Calvet, R. ; Chaves, Ryan C. G. ; Chen, Andrew ; Chevalier, J. ; Chretien, M. ; Colafrancesco, Sergio ; Cologna, Gabriele ; Condon, B. ; Conrad, Jan ; Couturier, C. ; Cui, Y. ; Davids, I. D. ; Degrange, B. ; Deil, Christoph ; deWilt, P. ; Djannati-Atai, Arache ; Domainko, Wilfried ; Donath, Axel ; Dubus, Guillaume ; Dutson, Kate ; Dyks, J. ; Dyrda, M. ; Edwards, T. ; Egberts, Kathrin ; Eger, P. ; Ernenwein, J. -P. ; Eschbach, S. ; Farnier, C. ; Fegan, Stuart ; Fernandes, M. V. ; Fiasson, A. ; Fontaine, G. ; Foerster, A. ; Funk, S. ; Füßling, Matthias ; Gabici, Stefano ; Gajdus, M. ; Gallant, Y. A. ; Garrigoux, T. ; Giavitto, Gianluca ; Giebels, B. ; Glicenstein, J. F. ; Gottschall, Daniel ; Goyal, A. ; Grondin, M. -H. ; Grudzinska, M. ; Hadasch, Daniela ; Hahn, J. ; Hawkes, J. ; Heinzelmann, G. ; Henri, Gilles ; Hermann, G. ; Hervet, Olivier ; Hillert, A. ; Hinton, James Anthony ; Hofmann, Werner ; Hoischen, Clemens ; Holler, M. ; Horns, D. ; Ivascenko, Alex ; Jacholkowska, A. ; Jamrozy, Marek ; Janiak, M. ; Jankowsky, D. ; Jankowsky, Felix ; Jingo, M. ; Jogler, Tobias ; Jouvin, Lea ; Jung-Richardt, Ira ; Kastendieck, M. A. ; Katarzynski, Krzysztof ; Katz, Uli ; Kerszberg, D. ; Khelifi, B. ; Kieffer, M. ; King, J. ; Klepser, S. ; Klochkov, Dmitry ; Kluzniak, W. ; Kolitzus, D. ; Komin, Nu. ; Kosack, K. ; Krakau, S. ; Kraus, Michael ; Krayzel, F. ; Kruger, P. P. ; Laffon, H. ; Lamanna, G. ; Lau, Jeanie ; Lees, J. -P. ; Lefaucheur, J. ; Lefranc, V. ; Lemiere, A. ; Lemoine-Goumard, M. ; Lenain, J. -P. ; Leser, Eva ; Lohse, Thomas ; Lorentz, M. ; Lui, R. ; Lypova, Iryna ; Marandon, Vincent ; Marcowith, Alexandre ; Mariaud, C. ; Marx, R. ; Maurin, G. ; Maxted, N. ; Mayer, Michael ; Meintjes, Petrus Johannes ; Menzler, U. ; Meyer, Manuel ; Mitchell, A. M. W. ; Moderski, R. ; Mohamed, M. ; Mora, K. ; Moulin, Emmanuel ; Murach, T. ; de Naurois, Mathieu ; Niederwanger, F. ; Niemiec, J. ; Oakes, L. ; Odaka, Hirokazu ; Ohm, Stefan ; Oettl, S. ; Ostrowski, M. ; Oya, I. ; Padovani, Marco ; Panter, M. ; Parsons, R. D. ; Arribas, M. Paz ; Pekeur, N. W. ; Pelletier, G. ; Petrucci, P. -O. ; Peyaud, B. ; Pita, S. ; Poon, Helen ; Prokhorov, Dmitry ; Prokoph, Heike ; Puehlhofer, Gerd ; Punch, Michael ; Quirrenbach, Andreas ; Raab, S. ; Reimer, Anita ; Reimer, Olaf ; Renaud, M. ; de los Reyes, R. ; Rieger, Frank ; Romoli, Carlo ; Rosier-Lees, S. ; Rowell, G. ; Rudak, B. ; Rulten, C. B. ; Sahakian, V. ; Salek, David ; Sanchez, David A. ; Santangelo, Andrea ; Sasaki, Manami ; Schlickeiser, Reinhard ; Schussler, F. ; Schulz, Andreas ; Schwanke, U. ; Schwemmer, S. ; Seyffert, A. S. ; Shafi, N. ; Simoni, R. ; Sol, H. ; Spanier, Felix ; Spengler, G. ; Spiess, F. ; Stawarz, Lukasz ; Steenkamp, R. ; Stegmann, Christian ; Stinzing, F. ; Stycz, K. ; Sushch, Iurii ; Tavernet, J. -P. ; Tavernier, T. ; Taylor, A. M. ; Terrier, R. ; Tluczykont, Martin ; Trichard, C. ; Tuffs, R. ; van der Walt, Johan ; van Eldik, Christopher ; van Soelen, Brian ; Vasileiadis, Georges ; Veh, J. ; Venter, C. ; Viana, A. ; Vincent, P. ; Vink, Jacco ; Voisin, F. ; Voelk, Heinrich J. ; Vuillaume, Thomas ; Wadiasingh, Z. ; Wagner, Stefan J. ; Wagner, P. ; Wagner, R. M. ; White, R. ; Wierzcholska, Alicja ; Willmann, P. ; Woernlein, A. ; Wouters, Denis ; Yang, R. ; Zabalza, Victor ; Zaborov, D. ; Zacharias, M. ; Zdziarski, A. A. ; Zech, Andreas ; Zefi, F. ; Ziegler, A. ; Zywucka, Natalia
The inner region of the Milky Way halo harbors a large amount of dark matter (DM). Given its proximity, it is one of the most promising targets to look for DM. We report on a search for the annihilations of DM particles using gamma-ray observations towards the inner 300 pc of the Milky Way, with the H.E.S.S. array of ground-based Cherenkov telescopes. The analysis is based on a 2D maximum likelihood method using Galactic Center (GC) data accumulated by H.E.S.S. over the last 10 years (2004-2014), and does not show any significant gamma-ray signal above background. Assuming Einasto and Navarro-Frenk-White DM density profiles at the GC, we derive upper limits on the annihilation cross section <sigma nu >. These constraints are the strongest obtained so far in the TeV DM mass range and improve upon previous limits by a factor 5. For the Einasto profile, the constraints reach <sigma nu > values of 6 x 10(-26) cm(3) s(-1) in the W+W- channel for a DM particle mass of 1.5 TeV, and 2 x 10(-26) cm(3) s(-1) in the tau(+)tau(-) channel for a 1 TeV mass. For the first time, ground-based gamma-ray observations have reached sufficient sensitivity to probe <sigma nu > values expected from the thermal relic density for TeV DM particles.
Horikoshi, Momoko ; Yaghootkar, Hanieh ; Mook-Kanamori, Dennis O. ; Sovio, Ulla ; Taal, H. Rob ; Hennig, Branwen J. ; Bradfield, Jonathan P. ; St Pourcain, Beate ; Evans, David M. ; Charoen, Pimphen ; Kaakinen, Marika ; Cousminer, Diana L. ; Lehtimaki, Terho ; Kreiner-Moller, Eskil ; Warrington, Nicole M. ; Bustamante, Mariona ; Feenstra, Bjarke ; Berry, Diane J. ; Thiering, Elisabeth ; Pfab, Thiemo ; Barton, Sheila J. ; Shields, Beverley M. ; Kerkhof, Marjan ; van Leeuwen, Elisabeth M. ; Fulford, Anthony J. ; Kutalik, Zoltan ; Zhao, Jing Hua ; den Hoed, Marcel ; Mahajan, Anubha ; Lindi, Virpi ; Goh, Liang-Kee ; Hottenga, Jouke-Jan ; Wu, Ying ; Raitakari, Olli T. ; Harder, Marie N. ; Meirhaeghe, Aline ; Ntalla, Ioanna ; Salem, Rany M. ; Jameson, Karen A. ; Zhou, Kaixin ; Monies, Dorota M. ; Lagou, Vasiliki ; Kirin, Mirna ; Heikkinen, Jani ; Adair, Linda S. ; Alkuraya, Fowzan S. ; Al-Odaib, Ali ; Amouyel, Philippe ; Andersson, Ehm Astrid ; Bennett, Amanda J. ; Blakemore, Alexandra I. F. ; Buxton, Jessica L. ; Dallongeville, Jean ; Das, Shikta ; de Geus, Eco J. C. ; Estivill, Xavier ; Flexeder, Claudia ; Froguel, Philippe ; Geller, Frank ; Godfrey, Keith M. ; Gottrand, Frederic ; Groves, Christopher J. ; Hansen, Torben ; Hirschhorn, Joel N. ; Hofman, Albert ; Hollegaard, Mads V. ; Hougaard, David M. ; Hyppoenen, Elina ; Inskip, Hazel M. ; Isaacs, Aaron ; Jorgensen, Torben ; Kanaka-Gantenbein, Christina ; Kemp, John P. ; Kiess, Wieland ; Kilpelainen, Tuomas O. ; Klopp, Norman ; Knight, Bridget A. ; Kuzawa, Christopher W. ; McMahon, George ; Newnham, John P. ; Niinikoski, Harri ; Oostra, Ben A. ; Pedersen, Louise ; Postma, Dirkje S. ; Ring, Susan M. ; Rivadeneira, Fernando ; Robertson, Neil R. ; Sebert, Sylvain ; Simell, Olli ; Slowinski, Torsten ; Tiesler, Carla M. T. ; Toenjes, Anke ; Vaag, Allan ; Viikari, Jorma S. ; Vink, Jacqueline M. ; Vissing, Nadja Hawwa ; Wareham, Nicholas J. ; Willemsen, Gonneke ; Witte, Daniel R. ; Zhang, Haitao ; Zhao, Jianhua ; Wilson, James F. ; Stumvoll, Michael ; Prentice, Andrew M. ; Meyer, Brian F. ; Pearson, Ewan R. ; Boreham, Colin A. G. ; Cooper, Cyrus ; Gillman, Matthew W. ; Dedoussis, George V. ; Moreno, Luis A. ; Pedersen, Oluf ; Saarinen, Maiju ; Mohlke, Karen L. ; Boomsma, Dorret I. ; Saw, Seang-Mei ; Lakka, Timo A. ; Koerner, Antje ; Loos, Ruth J. F. ; Ong, Ken K. ; Vollenweider, Peter ; van Duijn, Cornelia M. ; Koppelman, Gerard H. ; Hattersley, Andrew T. ; Holloway, John W. ; Hocher, Berthold ; Heinrich, Joachim ; Power, Chris ; Melbye, Mads ; Guxens, Monica ; Pennell, Craig E. ; Bonnelykke, Klaus ; Bisgaard, Hans ; Eriksson, Johan G. ; Widen, Elisabeth ; Hakonarson, Hakon ; Uitterlinden, Andre G. ; Pouta, Anneli ; Lawlor, Debbie A. ; Smith, George Davey ; Frayling, Timothy M. ; McCarthy, Mark I. ; Grant, Struan F. A. ; Jaddoe, Vincent W. V. ; Jarvelin, Marjo-Riitta ; Timpson, Nicholas J. ; Prokopenko, Inga ; Freathy, Rachel M.
Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood(1). Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits(2). In an expanded genome-wide association metaanalysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
Abramowski, Attila ; Aharonian, Felix A. ; Benkhali, Faical Ait ; Akhperjanian, A. G. ; Angüner, Ekrem Oǧuzhan ; Backes, Michael ; Balenderan, Shangkari ; Balzer, Arnim ; Barnacka, Anna ; Becherini, Yvonne ; Tjus, Julia Becker ; Berge, David ; Bernhard, Sabrina ; Bernlöhr, Konrad ; Birsin, E. ; Biteau, Jonathan ; Böttcher, Markus ; Boisson, Catherine ; Bolmont, J. ; Bordas, Pol ; Bregeon, Johan ; Brun, Francois ; Brun, Pierre ; Bryan, Mark ; Bulik, Tomasz ; Carrigan, Svenja ; Casanova, Sabrina ; Chadwick, Paula M. ; Chakraborty, Nachiketa ; Chalme-Calvet, R. ; Chaves, Ryan C. G. ; Chretien, M. ; Colafrancesco, Sergio ; Cologna, Gabriele ; Conrad, Jan ; Couturier, Claire ; Cui, Yudong ; Davids, Isak Delberth ; Degrange, Bernhard ; Deil, Christoph ; deWilt, P. ; Djannati-Ataï, A. ; Domainko, Wilfried ; Donath, Axel ; Dubus, G. ; Dutson, K. ; Dyks, J. ; Dyrda, M. ; Edwards, Tanya ; Egberts, Kathrin ; Eger, Peter ; Espigat, P. ; Farnier, C. ; Fegan, Stephen ; Feinstein, Fabrice ; Fernandes, Milton Virgilio ; Fernandez, Diane ; Fiasson, A. ; Fontaine, Gerard ; Förster, Andreas ; Fuessling, M. ; Gabici, S. ; Gajdus, M. ; Gallant, Yves A. ; Garrigoux, Tania ; Giavitto, G. ; Giebels, Berrie ; Glicenstein, Jean-Francois ; Gottschall, Daniel ; Grondin, M. -H. ; Grudzinska, M. ; Hadasch, Daniela ; Haeffner, S. ; Hahn, Joachim ; Harris, Jonathan ; Heinzelmann, Götz ; Henri, G. ; Hermann, German ; Hervet, O. ; Hillert, Andreas ; Hinton, James Anthony ; Hofmann, Werner ; Hofverberg, Petter ; Holler, Markus ; Horns, Dieter ; Ivascenko, Alex ; Jacholkowska, A. ; Jahn, C. ; Jamrozy, Marek ; Janiak, M. ; Jankowsky, F. ; Jung-Richardt, I. ; Kastendieck, Max Anton ; Katarzynski, K. ; Katz, U. ; Kaufmann, S. ; Khelifi, B. ; Kieffer, Michel ; Klepser, S. ; Klochkov, Dmitry ; Kluzniak, W. ; Kolitzus, David ; Komin, Nu ; Kosack, Karl ; Krakau, Steffen ; Krayzel, F. ; Krueger, Pat P. ; Laffon, H. ; Lamanna, G. ; Lefaucheur, J. ; Lefranc, Valentin ; Lemiere, A. ; Lemoine-Goumard, M. ; Lenain, J. -P. ; Lohse, Thomas ; Lopatin, A. ; Lu, Chia-Chun ; Marandon, Vincent ; Marcowith, Alexandre ; Marx, Ramin ; Maurin, G. ; Maxted, Nigel ; Mayer, Michael ; McComb, T. J. Lowry ; Mehault, J. ; Meintjes, P. J. ; Menzler, Ulf ; Meyer, M. ; Mitchell, Alison M. W. ; Moderski, R. ; Mohamed, M. ; Mora, K. ; Moulin, Emmanuel ; Murach, Thomas ; de Naurois, Mathieu ; Niemiec, J. ; Nolan, Sam J. ; Oakes, Louise ; Odaka, Hirokazu ; Ohm, S. ; Optiz, Björn ; Ostrowski, Michal ; Oya, I. ; Panter, Michael ; Parsons, R. Daniel ; Arribas, M. Paz ; Pekeur, Nikki W. ; Pelletier, G. ; Petrucci, P. -O. ; Peyaud, B. ; Pita, S. ; Poon, Helen ; Pühlhofer, Gerd ; Punch, M. ; Quirrenbach, A. ; Raab, S. ; Reichardt, I. ; Reimer, Anita ; Reimer, Olaf ; Renaud, Metz ; de los Reyes, Raquel ; Rieger, Frank ; Romoli, C. ; Rosier-Lees, S. ; Rowell, G. ; Rudak, B. ; Rulten, C. B. ; Sahakian, Vardan ; Salek, D. ; Sanchez, David M. ; Santangelo, Andrea ; Schlickeiser, Reinhard ; Schuessler, F. ; Schulz, A. ; Schwanke, Ullrich ; Schwarzburg, S. ; Schwemmer, S. ; Sol, H. ; Spanier, Felix ; Spengler, G. ; Spies, Franziska ; Stawarz, Lukasz ; Steenkamp, Riaan ; Stegmann, Christian ; Stinzing, F. ; Stycz, K. ; Sushch, Iurii ; Tavernet, J. -P. ; Tavernier, T. ; Taylor, A. M. ; Terrier, R. ; Tluczykont, Martin ; Trichard, C. ; Valerius, K. ; van Eldik, C. ; van Soelen, B. ; Vasileiadis, Georges ; Veh, J. ; Venter, Christo ; Viana, Aion ; Vincent, P. ; Vink, Jacco ; Völk, Heinrich J. ; Volpe, Francesca ; Vorster, Martine ; Vuillaume, T. ; Wagner, S. J. ; Wagner, P. ; Wagner, R. M. ; Ward, Martin ; Weidinger, Matthias ; Weitzel, Quirin ; White, R. ; Wierzcholska, A. ; Willmann, P. ; Woernlein, A. ; Wouters, D. ; Yang, Ruizhi ; Zabalza, Victor ; Zaborov, Dmitry ; Zacharias, M. ; Zdziarski, A. A. ; Zech, Alraune ; Zechlin, Hannes -S.
Bauer, M. ; Banaschewski, Tobias ; Heinz, A. ; Kamp-Becker, I. ; Meyer-Lindenberg, A. ; Padberg, F. ; Rapp, Michael A. ; Rupprecht, R. ; Schneider, F. ; Schulze, T. G. ; Wittchen, Hans-Ulrich
Mental disorders are among the greatest medical and social challenges facing us. They can occur at all stages of life and are among the most important commonly occurring diseases. In Germany 28 % of the population suffer from a mental disorder every year, while the lifetime risk of suffering from a mental disorder is almost 50 %. Mental disorders cause great suffering for those affected and their social network. Quantitatively speaking, they can be considered to be among those diseases creating the greatest burden for society due to reduced productivity, absence from work and premature retirement. The Federal Ministry of Education and Research is funding a new research network from 2015 to 2019 with up to 35 million euros to investigate mental disorders in order to devise and develop better therapeutic measures and strategies for this population by means of basic and translational clinical research. This is the result of a competitive call for research proposals entitled research network for mental diseases. It is a nationwide network of nine consortia with up to ten psychiatric and clinical psychology partner institutions from largely university-based research facilities for adults and/or children and adolescents. Furthermore, three cross-consortia platform projects will seek to identify shared causes of diseases and new diagnostic modalities for anxiety disorders, attention deficit hyperactivity disorders (ADHS), autism, bipolar disorders, depression, schizophrenia and psychotic disorders as well as substance-related and addictive disorders. The spectrum of therapeutic approaches to be examined ranges from innovative pharmacological and psychotherapeutic treatment to novel brain stimulation procedures. In light of the enormous burden such diseases represent for society as a whole, a sustainable improvement in the financial support for those researching mental disorders seems essential. This network aims to become a nucleus for long overdue and sustained support for a German center for mental disorders.
Vaid, Akhil ; Somani, Sulaiman ; Russak, Adam J. ; De Freitas, Jessica K. ; Chaudhry, Fayzan F. ; Paranjpe, Ishan ; Johnson, Kipp W. ; Lee, Samuel J. ; Miotto, Riccardo ; Richter, Felix ; Zhao, Shan ; Beckmann, Noam D. ; Naik, Nidhi ; Kia, Arash ; Timsina, Prem ; Lala, Anuradha ; Paranjpe, Manish ; Golden, Eddye ; Danieletto, Matteo ; Singh, Manbir ; Meyer, Dara ; O'Reilly, Paul F. ; Huckins, Laura ; Kovatch, Patricia ; Finkelstein, Joseph ; Freeman, Robert M. ; Argulian, Edgar ; Kasarskis, Andrew ; Percha, Bethany ; Aberg, Judith A. ; Bagiella, Emilia ; Horowitz, Carol R. ; Murphy, Barbara ; Nestler, Eric J. ; Schadt, Eric E. ; Cho, Judy H. ; Cordon-Cardo, Carlos ; Fuster, Valentin ; Charney, Dennis S. ; Reich, David L. ; Böttinger, Erwin ; Levin, Matthew A. ; Narula, Jagat ; Fayad, Zahi A. ; Just, Allan C. ; Charney, Alexander W. ; Nadkarni, Girish N. ; Glicksberg, Benjamin S.
Background:
COVID-19 has infected millions of people worldwide and is responsible for several hundred thousand fatalities. The COVID-19 pandemic has necessitated thoughtful resource allocation and early identification of high-risk patients. However, effective methods to meet these needs are lacking.
Objective:
The aims of this study were to analyze the electronic health records (EHRs) of patients who tested positive for COVID-19 and were admitted to hospitals in the Mount Sinai Health System in New York City; to develop machine learning models for making predictions about the hospital course of the patients over clinically meaningful time horizons based on patient characteristics at admission; and to assess the performance of these models at multiple hospitals and time points.
Methods:
We used Extreme Gradient Boosting (XGBoost) and baseline comparator models to predict in-hospital mortality and critical events at time windows of 3, 5, 7, and 10 days from admission. Our study population included harmonized EHR data from five hospitals in New York City for 4098 COVID-19-positive patients admitted from March 15 to May 22, 2020. The models were first trained on patients from a single hospital (n=1514) before or on May 1, externally validated on patients from four other hospitals (n=2201) before or on May 1, and prospectively validated on all patients after May 1 (n=383). Finally, we established model interpretability to identify and rank variables that drive model predictions.
Results:
Upon cross-validation, the XGBoost classifier outperformed baseline models, with an area under the receiver operating characteristic curve (AUC-ROC) for mortality of 0.89 at 3 days, 0.85 at 5 and 7 days, and 0.84 at 10 days. XGBoost also performed well for critical event prediction, with an AUC-ROC of 0.80 at 3 days, 0.79 at 5 days, 0.80 at 7 days, and 0.81 at 10 days. In external validation, XGBoost achieved an AUC-ROC of 0.88 at 3 days, 0.86 at 5 days, 0.86 at 7 days, and 0.84 at 10 days for mortality prediction. Similarly, the unimputed XGBoost model achieved an AUC-ROC of 0.78 at 3 days, 0.79 at 5 days, 0.80 at 7 days, and 0.81 at 10 days. Trends in performance on prospective validation sets were similar. At 7 days, acute kidney injury on admission, elevated LDH, tachypnea, and hyperglycemia were the strongest drivers of critical event prediction, while higher age, anion gap, and C-reactive protein were the strongest drivers of mortality prediction.
Conclusions:
We externally and prospectively trained and validated machine learning models for mortality and critical events for patients with COVID-19 at different time horizons. These models identified at-risk patients and uncovered underlying relationships that predicted outcomes.
Meyer, Dominique M.-A. ; Velazquez, Pablo F. ; Petruk, Oleh ; Chiotellis, Alexandros ; Pohl, Martin ; Camps-Farina, Artemi ; Petrov, Miroslav ; Reynoso, Estela M. ; Toledo-Roy, Juan C. ; Schneiter, E. Matias ; Castellanos-Ramirez, Antonio ; Esquivel, Alejandro
Core-collapse supernova remnants are the gaseous nebulae of galactic interstellar media (ISM) formed after the explosive death of massive stars. Their morphology and emission properties depend both on the surrounding circumstellar structure shaped by the stellar wind-ISM interaction of the progenitor star and on the local conditions of the ambient medium. In the warm phase of the Galactic plane (n approximate to 1 cm(-3), T approximate to 8000 K), an organized magnetic field of strength 7 mu G has profound consequences on the morphology of the wind bubble of massive stars at rest. In this paper, we show through 2.5D magnetohydrodynamical simulations, in the context of a Wolf-Rayet-evolving 35 M 0 star, that it affects the development of its supernova remnant. When the supernova remnant reaches its middle age (15-20 kyr), it adopts a tubular shape that results from the interaction between the isotropic supernova ejecta and the anisotropic, magnetized, shocked stellar progenitor bubble into which the supernova blast wave expands. Our calculations for non-thermal emission, i.e. radio synchrotron and inverse-Compton radiation, reveal that such supernova remnants can, due to projection effects, appear as rectangular objects in certain cases. This mechanism for shaping a supernova remnant is similar to the bipolar and elliptical planetary nebula production by wind-wind interaction in the low-mass regime of stellar evolution. If such a rectangular core-collapse supernova remnant is created, the progenitor star must not have been a runaway star. We propose that such a mechanism is at work in the shaping of the asymmetric core-collapse supernova remnant Puppis A.
Early maternal care may counteract familial liability for psychopathology in the reward circuitry
(2018)
Holz, Nathalie E. ; Boecker-Schlier, Regina ; Jennen-Steinmetz, Christine ; Hohm, Erika ; Buchmann, Arlette F. ; Blomeyer, Dorothea ; Baumeister, Sarah ; Plichta, Michael M. ; Esser, Günter ; Schmidt, Martin ; Meyer-Lindenberg, Andreas ; Banaschewski, Tobias ; Brandeis, Daniel ; Laucht, Manfred
Reward processing is altered in various psychopathologies and has been shown to be susceptible to genetic and environmental influences. Here, we examined whether maternal care may buffer familial risk for psychiatric disorders in terms of reward processing. Functional magnetic resonance imaging during a monetary incentive delay task was acquired in participants of an epidemiological cohort study followed since birth (N = 172, 25 years). Early maternal stimulation was assessed during a standardized nursing/playing setting at the age of 3 months. Parental psychiatric disorders (familial risk) during childhood and the participants’ previous psychopathology were assessed by diagnostic interview. With high familial risk, higher maternal stimulation was related to increasing activation in the caudate head, the supplementary motor area, the cingulum and the middle frontal gyrus during reward anticipation, with the opposite pattern found in individuals with no familial risk. In contrast, higher maternal stimulation was associated with decreasing caudate head activity during reward delivery and reduced levels of attention deficit hyperactivity disorder (ADHD) in the high-risk group. Decreased caudate head activity during reward anticipation and increased activity during delivery were linked to ADHD. These findings provide evidence of a long-term association of early maternal stimulation on both adult neurobiological systems of reward underlying externalizing behavior and ADHD during development.
Holz, Nathalie E. ; Buchmann, Arlette F. ; Boecker-Schlier, Regina ; Blomeyer, Dorothea ; Baumeister, Sarah ; Wolf, Isabella ; Rietschel, Marcella ; Witt, Stephanie H. ; Plichta, Michael M. ; Meyer-Lindenberg, Andreas ; Banaschewski, Tobias ; Brandeis, Daniel ; Laucht, Manfred
Accumulating evidence suggests a role of FKBP5, a co-chaperone regulating the glucocorticoid receptor sensitivity, in the etiology of depression and anxiety disorders. Based on recent findings of altered amygdala activity following childhood adversity, the present study aimed at clarifying the impact of genetic variation in FKBP5 on threat-related neural activity and coupling as well as morphometric alterations in stress-sensitive brain systems. Functional magnetic resonance imaging during an emotional face-matching task was performed in 153 healthy young adults (66 males) from a high-risk community sample followed since birth. Voxel-based morphometry was applied to study structural alterations and DNA was genotyped for FKBP5 rs1360780. Childhood adversity was measured using retrospective self-report (Childhood Trauma Questionnaire) and by a standardized parent interview assessing childhood family adversity. Depression was assessed by the Beck Depression Inventory. There was a main effect of FKBP5 on the left amygdala, with T homozygotes showing the highest activity, largest volume and increased coupling with the left hippocampus and the orbitofrontal cortex (OFC). Moreover, amygdala-OFC coupling proved to be associated with depression in this genotype. In addition, our results support previous evidence of a gene-environment interaction on right amygdala activity with respect to retrospective assessment of childhood adversity, but clarify that this does not generalize to the prospective assessment. These findings indicated that activity in T homozygotes increased with the level of adversity, whereas the opposite pattern emerged in C homozygotes, with CT individuals being intermediate. The present results point to a functional involvement of FKBP5 in intermediate phenotypes associated with emotional processing, suggesting a possible mechanism for this gene in conferring susceptibility to stress-related disorders.