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Aarts, Alexander A. ; Anderson, Joanna E. ; Anderson, Christopher J. ; Attridge, Peter R. ; Attwood, Angela ; Axt, Jordan ; Babel, Molly ; Bahnik, Stepan ; Baranski, Erica ; Barnett-Cowan, Michael ; Bartmess, Elizabeth ; Beer, Jennifer ; Bell, Raoul ; Bentley, Heather ; Beyan, Leah ; Binion, Grace ; Borsboom, Denny ; Bosch, Annick ; Bosco, Frank A. ; Bowman, Sara D. ; Brandt, Mark J. ; Braswell, Erin ; Brohmer, Hilmar ; Brown, Benjamin T. ; Brown, Kristina ; Bruening, Jovita ; Calhoun-Sauls, Ann ; Callahan, Shannon P. ; Chagnon, Elizabeth ; Chandler, Jesse ; Chartier, Christopher R. ; Cheung, Felix ; Christopherson, Cody D. ; Cillessen, Linda ; Clay, Russ ; Cleary, Hayley ; Cloud, Mark D. ; Cohn, Michael ; Cohoon, Johanna ; Columbus, Simon ; Cordes, Andreas ; Costantini, Giulio ; Alvarez, Leslie D. Cramblet ; Cremata, Ed ; Crusius, Jan ; DeCoster, Jamie ; DeGaetano, Michelle A. ; Della Penna, Nicolas ; den Bezemer, Bobby ; Deserno, Marie K. ; Devitt, Olivia ; Dewitte, Laura ; Dobolyi, David G. ; Dodson, Geneva T. ; Donnellan, M. Brent ; Donohue, Ryan ; Dore, Rebecca A. ; Dorrough, Angela ; Dreber, Anna ; Dugas, Michelle ; Dunn, Elizabeth W. ; Easey, Kayleigh ; Eboigbe, Sylvia ; Eggleston, Casey ; Embley, Jo ; Epskamp, Sacha ; Errington, Timothy M. ; Estel, Vivien ; Farach, Frank J. ; Feather, Jenelle ; Fedor, Anna ; Fernandez-Castilla, Belen ; Fiedler, Susann ; Field, James G. ; Fitneva, Stanka A. ; Flagan, Taru ; Forest, Amanda L. ; Forsell, Eskil ; Foster, Joshua D. ; Frank, Michael C. ; Frazier, Rebecca S. ; Fuchs, Heather ; Gable, Philip ; Galak, Jeff ; Galliani, Elisa Maria ; Gampa, Anup ; Garcia, Sara ; Gazarian, Douglas ; Gilbert, Elizabeth ; Giner-Sorolla, Roger ; Glöckner, Andreas ; Göllner, Lars ; Goh, Jin X. ; Goldberg, Rebecca ; Goodbourn, Patrick T. ; Gordon-McKeon, Shauna ; Gorges, Bryan ; Gorges, Jessie ; Goss, Justin ; Graham, Jesse ; Grange, James A. ; Gray, Jeremy ; Hartgerink, Chris ; Hartshorne, Joshua ; Hasselman, Fred ; Hayes, Timothy ; Heikensten, Emma ; Henninger, Felix ; Hodsoll, John ; Holubar, Taylor ; Hoogendoorn, Gea ; Humphries, Denise J. ; Hung, Cathy O. -Y. ; Immelman, Nathali ; Irsik, Vanessa C. ; Jahn, Georg ; Jaekel, Frank ; Jekel, Marc ; Johannesson, Magnus ; Johnson, Larissa G. ; Johnson, David J. ; Johnson, Kate M. ; Johnston, William J. ; Jonas, Kai ; Joy-Gaba, Jennifer A. ; Kappes, Heather Barry ; Kelso, Kim ; Kidwell, Mallory C. ; Kim, Seung Kyung ; Kirkhart, Matthew ; Kleinberg, Bennett ; Knezevic, Goran ; Kolorz, Franziska Maria ; Kossakowski, Jolanda J. ; Krause, Robert Wilhelm ; Krijnen, Job ; Kuhlmann, Tim ; Kunkels, Yoram K. ; Kyc, Megan M. ; Lai, Calvin K. ; Laique, Aamir ; Lakens, Daniel ; Lane, Kristin A. ; Lassetter, Bethany ; Lazarevic, Ljiljana B. ; LeBel, Etienne P. ; Lee, Key Jung ; Lee, Minha ; Lemm, Kristi ; Levitan, Carmel A. ; Lewis, Melissa ; Lin, Lin ; Lin, Stephanie ; Lippold, Matthias ; Loureiro, Darren ; Luteijn, Ilse ; Mackinnon, Sean ; Mainard, Heather N. ; Marigold, Denise C. ; Martin, Daniel P. ; Martinez, Tylar ; Masicampo, E. J. ; Matacotta, Josh ; Mathur, Maya ; May, Michael ; Mechin, Nicole ; Mehta, Pranjal ; Meixner, Johannes ; Melinger, Alissa ; Miller, Jeremy K. ; Miller, Mallorie ; Moore, Katherine ; Möschl, Marcus ; Motyl, Matt ; Müller, Stephanie M. ; Munafo, Marcus ; Neijenhuijs, Koen I. ; Nervi, Taylor ; Nicolas, Gandalf ; Nilsonne, Gustav ; Nosek, Brian A. ; Nuijten, Michele B. ; Olsson, Catherine ; Osborne, Colleen ; Ostkamp, Lutz ; Pavel, Misha ; Penton-Voak, Ian S. ; Perna, Olivia ; Pernet, Cyril ; Perugini, Marco ; Pipitone, R. Nathan ; Pitts, Michael ; Plessow, Franziska ; Prenoveau, Jason M. ; Rahal, Rima-Maria ; Ratliff, Kate A. ; Reinhard, David ; Renkewitz, Frank ; Ricker, Ashley A. ; Rigney, Anastasia ; Rivers, Andrew M. ; Roebke, Mark ; Rutchick, Abraham M. ; Ryan, Robert S. ; Sahin, Onur ; Saide, Anondah ; Sandstrom, Gillian M. ; Santos, David ; Saxe, Rebecca ; Schlegelmilch, Rene ; Schmidt, Kathleen ; Scholz, Sabine ; Seibel, Larissa ; Selterman, Dylan Faulkner ; Shaki, Samuel ; Simpson, William B. ; Sinclair, H. Colleen ; Skorinko, Jeanine L. M. ; Slowik, Agnieszka ; Snyder, Joel S. ; Soderberg, Courtney ; Sonnleitner, Carina ; Spencer, Nick ; Spies, Jeffrey R. ; Steegen, Sara ; Stieger, Stefan ; Strohminger, Nina ; Sullivan, Gavin B. ; Talhelm, Thomas ; Tapia, Megan ; te Dorsthorst, Anniek ; Thomae, Manuela ; Thomas, Sarah L. ; Tio, Pia ; Traets, Frits ; Tsang, Steve ; Tuerlinckx, Francis ; Turchan, Paul ; Valasek, Milan ; Van Aert, Robbie ; van Assen, Marcel ; van Bork, Riet ; van de Ven, Mathijs ; van den Bergh, Don ; van der Hulst, Marije ; van Dooren, Roel ; van Doorn, Johnny ; van Renswoude, Daan R. ; van Rijn, Hedderik ; Vanpaemel, Wolf ; Echeverria, Alejandro Vasquez ; Vazquez, Melissa ; Velez, Natalia ; Vermue, Marieke ; Verschoor, Mark ; Vianello, Michelangelo ; Voracek, Martin ; Vuu, Gina ; Wagenmakers, Eric-Jan ; Weerdmeester, Joanneke ; Welsh, Ashlee ; Westgate, Erin C. ; Wissink, Joeri ; Wood, Michael ; Woods, Andy ; Wright, Emily ; Wu, Sining ; Zeelenberg, Marcel ; Zuni, Kellylynn
Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.
Koenig, Julian ; Abler, Birgit ; Agartz, Ingrid ; akerstedt, Torbjorn ; Andreassen, Ole A. ; Anthony, Mia ; Baer, Karl-Juergen ; Bertsch, Katja ; Brown, Rebecca C. ; Brunner, Romuald ; Carnevali, Luca ; Critchley, Hugo D. ; Cullen, Kathryn R. ; de Geus, Eco J. C. ; de la Cruz, Feliberto ; Dziobek, Isabel ; Ferger, Marc D. ; Fischer, Hakan ; Flor, Herta ; Gaebler, Michael ; Gianaros, Peter J. ; Giummarra, Melita J. ; Greening, Steven G. ; Guendelman, Simon ; Heathers, James A. J. ; Herpertz, Sabine C. ; Hu, Mandy X. ; Jentschke, Sebastian ; Kaess, Michael ; Kaufmann, Tobias ; Klimes-Dougan, Bonnie ; Koelsch, Stefan ; Krauch, Marlene ; Kumral, Deniz ; Lamers, Femke ; Lee, Tae-Ho ; Lekander, Mats ; Lin, Feng ; Lotze, Martin ; Makovac, Elena ; Mancini, Matteo ; Mancke, Falk ; Mansson, Kristoffer N. T. ; Manuck, Stephen B. ; Mather, Mara ; Meeten, Frances ; Min, Jungwon ; Mueller, Bryon ; Muench, Vera ; Nees, Frauke ; Nga, Lin ; Nilsonne, Gustav ; Ordonez Acuna, Daniela ; Osnes, Berge ; Ottaviani, Cristina ; Penninx, Brenda W. J. H. ; Ponzio, Allison ; Poudel, Govinda R. ; Reinelt, Janis ; Ren, Ping ; Sakaki, Michiko ; Schumann, Andy ; Sorensen, Lin ; Specht, Karsten ; Straub, Joana ; Tamm, Sandra ; Thai, Michelle ; Thayer, Julian F. ; Ubani, Benjamin ; van Der Mee, Denise J. ; van Velzen, Laura S. ; Ventura-Bort, Carlos ; Villringer, Arno ; Watson, David R. ; Wei, Luqing ; Wendt, Julia ; Schreiner, Melinda Westlund ; Westlye, Lars T. ; Weymar, Mathias ; Winkelmann, Tobias ; Wu, Guo-Rong ; Yoo, Hyun Joo ; Quintana, Daniel S.
Understanding the association between autonomic nervous system [ANS] function and brain morphology across the lifespan provides important insights into neurovisceral mechanisms underlying health and disease. Resting-state ANS activity, indexed by measures of heart rate [HR] and its variability [HRV] has been associated with brain morphology, particularly cortical thickness [CT]. While findings have been mixed regarding the anatomical distribution and direction of the associations, these inconsistencies may be due to sex and age differences in HR/HRV and CT. Previous studies have been limited by small sample sizes, which impede the assessment of sex differences and aging effects on the association between ANS function and CT. To overcome these limitations, 20 groups worldwide contributed data collected under similar protocols of CT assessment and HR/HRV recording to be pooled in a mega-analysis (N = 1,218 (50.5% female), mean age 36.7 years (range: 12-87)). Findings suggest a decline in HRV as well as CT with increasing age. CT, particularly in the orbitofrontal cortex, explained additional variance in HRV, beyond the effects of aging. This pattern of results may suggest that the decline in HRV with increasing age is related to a decline in orbitofrontal CT. These effects were independent of sex and specific to HRV; with no significant association between CT and HR. Greater CT across the adult lifespan may be vital for the maintenance of healthy cardiac regulation via the ANS-or greater cardiac vagal activity as indirectly reflected in HRV may slow brain atrophy. Findings reveal an important association between CT and cardiac parasympathetic activity with implications for healthy aging and longevity that should be studied further in longitudinal research.
Yedoma-extremely ice-rich permafrost with massive ice wedges formed during the Late Pleistocene-is vulnerable to thawing and degradation under climate warming. Thawing of ice-rich Yedoma results in lowering of surface elevations. Quantitative knowledge about surface elevation changes helps us to understand the freeze-thaw processes of the active layer and the potential degradation of Yedoma deposits. In this study, we use C-band Sentinel-1 InSAR measurements to map the elevation changes over ice-rich Yedoma uplands on Sobo-Sise Island, Lena Delta with frequent revisit observations (as short as six or 12 days). We observe significant seasonal thaw subsidence during summer months and heterogeneous inter-annual elevation changes from 2016-17. We also observe interesting patterns of stronger seasonal thaw subsidence on elevated flat Yedoma uplands by comparing to the surrounding Yedoma slopes. Inter-annual analyses from 2016-17 suggest that our observed positive surface elevation changes are likely caused by the delayed progression of the thaw season in 2017, associated with mean annual air temperature fluctuations.
Yedoma-extremely ice-rich permafrost with massive ice wedges formed during the Late Pleistocene-is vulnerable to thawing and degradation under climate warming. Thawing of ice-rich Yedoma results in lowering of surface elevations. Quantitative knowledge about surface elevation changes helps us to understand the freeze-thaw processes of the active layer and the potential degradation of Yedoma deposits. In this study, we use C-band Sentinel-1 InSAR measurements to map the elevation changes over ice-rich Yedoma uplands on Sobo-Sise Island, Lena Delta with frequent revisit observations (as short as six or 12 days). We observe significant seasonal thaw subsidence during summer months and heterogeneous inter-annual elevation changes from 2016-17. We also observe interesting patterns of stronger seasonal thaw subsidence on elevated flat Yedoma uplands by comparing to the surrounding Yedoma slopes. Inter-annual analyses from 2016-17 suggest that our observed positive surface elevation changes are likely caused by the delayed progression of the thaw season in 2017, associated with mean annual air temperature fluctuations.
Furniss, A. ; Noda, K. ; Boggs, S. ; Chiang, J. ; Christensen, F. ; Craig, W. ; Giommi, P. ; Hailey, C. ; Harisson, F. ; Madejski, G. ; Nalewajko, K. ; Perri, M. ; Stern, D. ; Urry, M. ; Verrecchia, F. ; Zhang, W. ; Ahnen, M. L. ; Ansoldi, S. ; Antonelli, L. A. ; Antoranz, P. ; Babic, A. ; Banerjee, B. ; Bangale, P. ; de Almeida, U. Barres ; Barrio, J. A. ; Becerra Gonzalez, J. ; Bednarek, W. ; Bernardini, E. ; Biasuzzi, B. ; Biland, A. ; Blanch Bigas, O. ; Bonnefoy, S. ; Bonnoli, G. ; Borracci, F. ; Bretz, T. ; Carmona, E. ; Carosi, A. ; Chatterjee, A. ; Clavero, R. ; Colin, P. ; Colombo, E. ; Contreras, J. L. ; Cortina, J. ; Covino, S. ; Da Vela, P. ; Dazzi, F. ; De Angelis, A. ; De Caneva, G. ; De Lotto, B. ; de Ona Wilhelmi, E. ; Delgado Mendez, C. ; Di Pierro, F. ; Prester, Dijana Dominis ; Dorner, D. ; Doro, M. ; Einecke, S. ; Eisenacher Glawion, D. ; Elsaesser, D. ; Fernandez-Barral, A. ; Fidalgo, D. ; Fonseca, M. V. ; Font, L. ; Frantzen, K. ; Fruck, C. ; Galindo, D. ; Garcia Lopez, R. J. ; Garczarczyk, M. ; Garrido Terrats, D. ; Gaug, M. ; Giammaria, P. ; Godinovic, N. ; Gonzalez Munoz, A. ; Guberman, D. ; Hanabata, Y. ; Hayashida, M. ; Herrera, J. ; Hose, J. ; Hrupec, D. ; Hughes, G. ; Idec, W. ; Kellermann, H. ; Kodani, K. ; Konno, Y. ; Kubo, H. ; Kushida, J. ; La Barbera, A. ; Lelas, D. ; Lewandowska, N. ; Lindfors, E. ; Lombardi, S. ; Longo, F. ; Lopez, M. ; Lopez-Coto, R. ; Lopez-Oramas, A. ; Lorenz, E. ; Majumdar, P. ; Makariev, M. ; Mallot, K. ; Maneva, G. ; Manganaro, M. ; Mannheim, K. ; Maraschi, L. ; Marcote, B. ; Mariotti, M. ; Martinez, M. ; Mazin, D. ; Menzel, U. ; Miranda, J. M. ; Mirzoyan, R. ; Moralejo, A. ; Nakajima, D. ; Neustroev, V. ; Niedzwiecki, A. ; Nievas Rosillo, M. ; Nilsson, K. ; Nishijima, K. ; Orito, R. ; Overkemping, A. ; Paiano, S. ; Palacio, J. ; Palatiello, M. ; Paneque, D. ; Paoletti, R. ; Paredes, J. M. ; Paredes-Fortuny, X. ; Persic, M. ; Poutanen, J. ; Moroni, P. G. Prada ; Prandini, E. ; Puljak, I. ; Reinthal, R. ; Rhode, W. ; Ribo, M. ; Rico, J. ; Garcia, J. Rodriguez ; Saito, T. ; Saito, K. ; Satalecka, K. ; Scapin, V. ; Schultz, C. ; Schweizer, T. ; Shore, S. N. ; Sillanpaa, A. ; Sitarek, J. ; Snidaric, I. ; Sobczynska, D. ; Stamerra, A. ; Steinbring, T. ; Strzys, M. ; Takalo, L. ; Takami, H. ; Tavecchio, F. ; Temnikov, P. ; Terzic, T. ; Tescaro, D. ; Teshima, M. ; Thaele, J. ; Torres, D. F. ; Toyama, T. ; Treves, A. ; Verguilov, V. ; Vovk, I. ; Will, M. ; Zanin, R. ; Archer, A. ; Benbow, W. ; Bird, R. ; Biteau, Jonathan ; Bugaev, V. ; Cardenzana, J. V. ; Cerruti, M. ; Chen, Xuhui ; Ciupik, L. ; Connolly, M. P. ; Cui, W. ; Dickinson, H. J. ; Dumm, J. ; Eisch, J. D. ; Falcone, A. ; Feng, Q. ; Finley, J. P. ; Fleischhack, H. ; Fortin, P. ; Fortson, L. ; Gerard, L. ; Gillanders, G. H. ; Griffin, S. ; Griffiths, S. T. ; Grube, J. ; Gyuk, G. ; Hakansson, Nils ; Holder, J. ; Humensky, T. B. ; Johnson, C. A. ; Kaaret, P. ; Kertzman, M. ; Kieda, D. ; Krause, M. ; Krennrich, F. ; Lang, M. J. ; Lin, T. T. Y. ; Maier, G. ; McArthur, S. ; McCann, A. ; Meagher, K. ; Moriarty, P. ; Mukherjee, R. ; Nieto, D. ; Ong, R. A. ; Park, N. ; Petry, D. ; Pohl, Martin ; Popkow, A. ; Ragan, K. ; Ratliff, G. ; Reyes, L. C. ; Reynolds, P. T. ; Richards, G. T. ; Roache, E. ; Santander, M. ; Sembroski, G. H. ; Shahinyan, K. ; Staszak, D. ; Telezhinsky, Igor O. ; Tucci, J. V. ; Tyler, J. ; Vassiliev, V. V. ; Wakely, S. P. ; Weiner, O. M. ; Weinstein, A. ; Wilhelm, Alina ; Williams, D. A. ; Zitzer, B. ; Vince, O. ; Fuhrmann, L. ; Angelakis, E. ; Karamanavis, V. ; Myserlis, I. ; Krichbaum, T. P. ; Zensus, J. A. ; Ungerechts, H. ; Sievers, A. ; Bachev, R. ; Boettcher, Markus ; Chen, W. P. ; Damljanovic, G. ; Eswaraiah, C. ; Guver, T. ; Hovatta, T. ; Hughes, Z. ; Ibryamov, S. I. ; Joner, M. D. ; Jordan, B. ; Jorstad, S. G. ; Joshi, M. ; Kataoka, J. ; Kurtanidze, O. M. ; Kurtanidze, S. O. ; Lahteenmaki, A. ; Latev, G. ; Lin, H. C. ; Larionov, V. M. ; Mokrushina, A. A. ; Morozova, D. A. ; Nikolashvili, M. G. ; Raiteri, C. M. ; Ramakrishnan, V. ; Readhead, A. C. R. ; Sadun, A. C. ; Sigua, L. A. ; Semkov, E. H. ; Strigachev, A. ; Tammi, J. ; Tornikoski, M. ; Troitskaya, Y. V. ; Troitsky, I. S. ; Villata, M.
We report on simultaneous broadband observations of the TeV-emitting blazar Markarian 501 between 2013 April 1 and August 10, including the first detailed characterization of the synchrotron peak with Swift and NuSTAR. During the campaign, the nearby BL Lac object was observed in both a quiescent and an elevated state. The broadband campaign includes observations with NuSTAR, MAGIC, VERITAS, the Fermi Large Area Telescope, Swift X-ray Telescope and UV Optical Telescope, various ground-based optical instruments, including the GASP-WEBT program, as well as radio observations by OVRO, Metsahovi, and the F-Gamma consortium. Some of the MAGIC observations were affected by a sand layer from the Saharan desert, and had to be corrected using event-by-event corrections derived with a Light Detection and Ranging (LIDAR) facility. This is the first time that LIDAR information is used to produce a physics result with Cherenkov Telescope data taken during adverse atmospheric conditions, and hence sets a precedent for the current and future ground-based gamma-ray instruments. The NuSTAR instrument provides unprecedented sensitivity in hard X-rays, showing the source to display a spectral energy distribution (SED) between 3 and 79 keV consistent with a log-parabolic spectrum and hard X-ray variability on hour timescales. None (of the four extended NuSTAR observations) show evidence of the onset of inverse-Compton emission at hard X-ray energies. We apply a single-zone equilibrium synchrotron self-Compton (SSC) model to five simultaneous broadband SEDs. We find that the SSC model can reproduce the observed broadband states through a decrease in the magnetic field strength coinciding with an increase in the luminosity and hardness of the relativistic leptons responsible for the high-energy emission.
The ability of water to transport and transform soil materials is one of the main drivers of soil and landscape development. In turn, soil and landscape properties determine how water is distributed in soil landscapes. Understanding the complex dynamics of this co-evolution of soils, landscapes and the hydrological system is fundamental in adapting land management to changes in climate. Soil-Landscape Evolution Models (SLEMs) are used to simulate the development and evolution of soils and landscapes. However, many hydrologic processes, such as preferential flow and subsurface lateral flow, are currently absent in these models. This limits the applicability of SLEMs to improve our understanding of feedbacks in the hydro-pedo-geomorphological system. Implementation of these hydrologic processes in SLEMs faces several complications related to calculation demands, limited methods for linking pedogenic and hydrologic processes, and limited data on quantification of changes in the hydrological system over time. In this contribution, we first briefly review processes and feedbacks in soil-landscape-hydrological systems. Next, we elaborate on the development required to include these processes in SLEMs. We discuss the state-of-the-art knowledge, identify complications, give partial solutions and suggest important future development. The main requirements for incorporating hydrologic processes in SLEMs are: (1) designing a model framework that can deal with varying timescales for different sets of processes, (2) developing and implementing methods for simulating pedogenesis as a function of water flow, (3) improving and implementing knowledge on the evolution and dynamics of soil hydraulic properties over different timescales, and (4) improving the database on temporal changes and dynamics of flow paths.
Tubiana, C. ; Rinaldi, G. ; Guettler, C. ; Snodgrass, C. ; Shi, X. ; Hu, X. ; Marschall, R. ; Fulle, M. ; Bockeele-Morvan, D. ; Naletto, G. ; Capaccioni, F. ; Sierks, H. ; Arnold, G. ; Barucci, M. A. ; Bertaux, J-L ; Bertini, I ; Bodewits, D. ; Capria, M. T. ; Ciarniello, M. ; Cremonese, G. ; Crovisier, J. ; Da Deppo, V ; Debei, S. ; De Cecco, M. ; Deller, J. ; De Sanctis, M. C. ; Davidsson, B. ; Doose, L. ; Erard, S. ; Filacchione, G. ; Fink, U. ; Formisano, M. ; Fornasier, S. ; Gutierrez, P. J. ; Ip, W-H ; Ivanovski, S. ; Kappel, David ; Keller, H. U. ; Kolokolova, L. ; Koschny, D. ; Krueger, H. ; La Forgia, F. ; Lamy, P. L. ; Lara, L. M. ; Lazzarin, M. ; Levasseur-Regourd, A. C. ; Lin, Z-Y ; Longobardo, A. ; Lopez-Moreno, J. J. ; Marzari, F. ; Migliorini, A. ; Mottola, S. ; Rodrigo, R. ; Taylor, F. ; Toth, I ; Zakharov, V
Context. On 27 April 2015, when comet 67P/Churyumov-Gerasimenko was at 1.76 au from the Sun and moving toward perihelion, the OSIRIS and VIRTIS-M instruments on board the Rosetta spacecraft simultaneously observed the evolving dust and gas coma during a complete rotation of the comet. Aims. We aim to characterize the spatial distribution of dust, H2O, and CO2 gas in the inner coma. To do this, we performed a quantitative analysis of the release of dust and gas and compared the observed H2O production rate with the rate we calculated using a thermophysical model. Methods. For this study we selected OSIRIS WAC images at 612 nm (dust) and VIRTIS-M image cubes at 612 nm, 2700 nm (H2O emission band), and 4200 nm (CO2 emission band). We measured the average signal in a circular annulus to study the spatial variation around the comet, and in a sector of the annulus to study temporal variation in the sunward direction with comet rotation, both at a fixed distance of 3.1 km from the comet center. Results. The spatial correlation between dust and water, both coming from the sunlit side of the comet, shows that water is the main driver of dust activity in this time period. The spatial distribution of CO2 is not correlated with water and dust. There is no strong temporal correlation between the dust brightness and water production rate as the comet rotates. The dust brightness shows a peak at 0 degrees subsolar longitude, which is not pronounced in the water production. At the same epoch, there is also a maximum in CO2 production. An excess of measured water production with respect to the value calculated using a simple thermophysical model is observed when the head lobe and regions of the southern hemisphere with strong seasonal variations are illuminated (subsolar longitude 270 degrees-50 degrees). A drastic decrease in dust production when the water production (both measured and from the model) displays a maximum occurs when typical northern consolidated regions are illuminated and the southern hemisphere regions with strong seasonal variations are instead in shadow (subsolar longitude 50 degrees-90 degrees). Possible explanations of these observations are presented and discussed.
Gao, Lin-rui ; Wang, Guang ; Zhang, Jing ; Li, Shuai ; Chuai, Manli ; Bao, Yongping ; Hocher, Berthold ; Yang, Xuesong
An association has been proved between high salt consumption and cardiovascular mortality. In vertebrates, the heart is the first functional organ to be formed. However, it is not clear whether high-salt exposure has an adverse impact on cardiogenesis. Here we report high-salt exposure inhibited basement membrane breakdown by affecting RhoA, thus disturbing the expression of Slug/E-cadherin/N-cadherin/Laminin and interfering with mesoderm formation during the epithelial-mesenchymal transition(EMT). Furthermore, the DiI(+) cell migration trajectory in vivo and scratch wound assays in vitro indicated that high-salt exposure restricted cell migration of cardiac progenitors, which was caused by the weaker cytoskeleton structure and unaltered corresponding adhesion junctions at HH7. Besides, down-regulation of GATA4/5/6, Nkx2.5, TBX5, and Mef2c and up-regulation of Wnt3a/-catenin caused aberrant cardiomyocyte differentiation at HH7 and HH10. High-salt exposure also inhibited cell proliferation and promoted apoptosis. Most importantly, our study revealed that excessive reactive oxygen species(ROS)generated by high salt disturbed the expression of cardiac-related genes, detrimentally affecting the above process including EMT, cell migration, differentiation, cell proliferation and apoptosis, which is the major cause of malformation of heart tubes.