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The use of high-frequency sensors on profiling buoys to investigate physical, chemical, and biological processes in lakes is
increasing rapidly. Profiling buoys with automated winches and sensors that collect high-frequency chlorophyll fluorescence
(ChlF) profiles in 11 lakes in the Global Lake Ecological Observatory Network (GLEON) allowed the study of the vertical
and temporal distribution of ChlF, including the formation of subsurface chlorophyll maxima (SSCM). The effectiveness of 3
methods for sampling phytoplankton distributions in lakes, including (1) manual profiles, (2) single-depth buoys, and (3)
profiling buoys were assessed. High-frequency ChlF surface data and profiles were compared to predictions from the
Plankton Ecology Group (PEG) model. The depth-integrated ChlF dynamics measured by the profiling buoy data revealed a
greater complexity that neither conventional sampling nor the generalized PEG model captured. Conventional sampling
techniques would have missed SSCM in 7 of 11 study lakes. Although surface-only ChlF data underestimated average water
column ChlF, at times by nearly 2-fold in 4 of the lakes, overall there was a remarkable similarity between surface and mean
water column data. Contrary to the PEG model’s proposed negligible role for physical control of phytoplankton during the
growing season, thermal structure and light availability were closely associated with ChlF seasonal depth distribution. Thus,
an extension of the PEG model is proposed, with a new conceptual framework that explicitly includes physical metrics to
better predict SSCM formation in lakes and highlight when profiling buoys are especially informative.
Die Verwendung geographischer Namen in Karten und Atlanten ist ein in der
kartographischen Methodenlehre vernachlässigter Bereich, der aber Aufmerksamkeit
verdient, weil geographische Namen dort wichtige Funktionen erfüllen.
Sie identifizieren zwar nicht ein geographisches Objekt, erleichtern aber das
Kartenlesen, ermöglichen die Suche nach geographischen Objekten, weisen auf
Merkmale geographischer Objekte hin und lassen die kulturelle Einbettung eines
Ortes erkennen. Für Leser, denen der Name und der durch ihn bezeichnete Ort
bekannt sind, haben sie die zusätzliche Funktion von Etiketten und die Eigenschaft,
emotionale Bindungen zum Ort zu unterstützen. Es werden zudem sechs allgemeine
Grundsätze für die Verwendung von geographischen Namen in Atlanten genannt, ferner spezielle Grundsätze für die beiden Haupttypen von Atlanten, nämlich
wissenschaftliche Atlanten, die sich an ein internationales Publikum wenden, und populäre Atlanten, die v. a. ein heimisches Publikum ansprechen wollen.
Reduced expression of the Indy ("I am Not Dead, Yet") gene in lower organisms promotes longevity in a manner akin to caloric restriction. Deletion of the mammalian homolog of Indy (mIndy, Slc13a5) encoding for a plasma membrane-associated citrate transporter expressed highly in the liver, protects mice from high-fat diet-induced and aging-induced obesity and hepatic fat accumulation through a mechanism resembling caloric restriction. We studied a possible role of mIndy in human hepatic fat metabolism. In obese, insulin-resistant patients with nonalcoholic fatty liver disease, hepatic mIndy expression was increased and mIndy expression was also independently associated with hepatic steatosis. In nonhuman primates, a 2-year high-fat, high-sucrose diet increased hepatic mIndy expression. Liver microarray analysis showed that high mIndy expression was associated with pathways involved in hepatic lipid metabolism and immunological processes. Interleukin-6 (IL-6) was identified as a regulator of mIndy by binding to its cognate receptor. Studies in human primary hepatocytes confirmed that IL-6 markedly induced mIndy transcription through the IL-6 receptor and activation of the transcription factor signal transducer and activator of transcription 3, and a putative start site of the human mIndy promoter was determined. Activation of the IL-6-signal transducer and activator of transcription 3 pathway stimulated mIndy expression, enhanced cytoplasmic citrate influx, and augmented hepatic lipogenesis in vivo. In contrast, deletion of mIndy completely prevented the stimulating effect of IL-6 on citrate uptake and reduced hepatic lipogenesis. These data show that mIndy is increased in liver of obese humans and nonhuman primates with NALFD. Moreover, our data identify mIndy as a target gene of IL-6 and determine novel functions of IL-6 through mINDY. Conclusion: Targeting human mINDY may have therapeutic potential in obese patients with nonalcoholic fatty liver disease. German Clinical Trials Register: DRKS00005450.
Aus dem Inhalt:
- Die Rolle Nationaler Menschenrechtsinstitutionen bei der Umsetzung der UN-Leitprinzipien für Wirtschaft
und Menschenrechte: Paradoxien und Potenziale
- Lehrbuchbeispiel des Versagens: Die Schutzverantwortung und die Rohingya in Myanmar
- Rechtsfragen der Umsetzung von Urteilen des Europäischen Gerichtshofs für Menschenrechte
Hartmut Asche prägte über ein Vierteljahrhundert maßgeblich die Forschungsfelder der Geoinformation, Visualisierung und Kartographie. Die vorliegende Festschrift stellt eine würdige Gabe von Mitarbeiterinnen und Mitarbeitern des Institutes für Geographie der Universität Potsdam anlässlich seiner Emeritierung im März 2017 dar. International renommierte, Herrn Asches Karriere begleitende Autorinnen und Autoren, konnten für Fachbeiträge aus den Bereichen Geographie, Geoinformatik, Kartographie und Fernerkundung gewonnen werden. Es werden in fachlich hervorragender Weise Schwerpunkte umrissen, mit welchen Herr Asche sich in seiner von zahlreichen Höhepunkten geprägten wissenschaftlichen Karriere beschäftigte.
Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.