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We present the Pristine survey, a new narrow-band photometric survey focused on the metallicity-sensitive Ca H&K lines and conducted in the Northern hemisphere with the wide-field imager MegaCam on the Canada-France-Hawaii Telescope. This paper reviews our overall survey strategy and discusses the data processing and metallicity calibration. Additionally we review the application of these data to the main aims of the survey, which are to gather a large sample of the most metal-poor stars in the Galaxy, to further characterize the faintest Milky Way satellites, and to map the (metal-poor) substructure in the Galactic halo. The current Pristine footprint comprises over 1000 deg(2) in the Galactic halo ranging from b similar to 30 degrees to similar to 78 degrees and covers many known stellar substructures. We demonstrate that, for Sloan Digital Sky Survey (SDSS) stellar objects, we can calibrate the photometry at the 0.02-mag level. The comparison with existing spectroscopic metallicities from SDSS/Sloan Extension for Galactic Understanding and Exploration (SEGUE) and Large Sky Area Multi-Object Fiber Spectroscopic Telescope shows that, when combined with SDSS broad-band g and i photometry, we can use the CaHK photometry to infer photometric metallicities with an accuracy of similar to 0.2 dex from [Fe/H] = -0.5 down to the extremely metal-poor regime ([Fe/H] < -3.0). After the removal of various contaminants, we can efficiently select metal-poor stars and build a very complete sample with high purity. The success rate of uncovering [Fe/H](SEGUE) < -3.0 stars among [Fe/H](Pristine) < -3.0 selected stars is 24 per cent, and 85 per cent of the remaining candidates are still very metal poor ([Fe/H]<-2.0). We further demonstrate that Pristine is well suited to identify the very rare and pristine Galactic stars with [Fe/H] < -4.0, which can teach us valuable lessons about the early Universe.
Durch den demographischen Wandel wird das Erwerbspersonenpotential und damit die Anzahl erwerbstätiger Personen, insbesondere die Zahl der Fachkräfte in den kommen-den Jahren in Deutschland zurückgehen. Aufgrund dessen wird es für Arbeitgeber zukünftig schwieriger werden, qualifizierten Nachwuchs zu finden. Aufgrund seiner Alterstruktur und der zunehmenden Arbeitsverdichtung ist der öffentliche Dienst, sowie der Teilbereich der öffentlichen Verwaltung, stärker als andere Arbeitgeber mit der Notwendigkeit konfrontiert, mittelfristig externes Personal zu rekrutieren. In Anbetracht dessen ging die Arbeit der Frage nach, inwieweit die öffentliche Verwaltung das hierfür geeignete, innovative Instrument des Social - Media - Personalmarketings bereits imple-mentiert hat und wie sich das ermittelte Ergebnis erklären lässt. Hinsichtlich der aktuellen Anwendung konnte festgestellt werden, dass Social - Media - Personalmarketing erst vor Kurzem in der öffentlichen Verwaltung implementiert wurde und aufgrund dessen gegenwärtig primär zur operativen Personalgewinnung genutzt wird. Als erklärende Einflussfaktoren konnten im Rahmen einer empirischen Untersuchung die mangelnde Relevanz des Personalmarketings als Aufgabe der öffentlichen Verwaltung, der aktuelle Per-sonalbestand und dessen digitale Kompetenzen, sowie die hierarchisch geprägten Kommunikationswege innerhalb der öffentlichen Verwaltung ermittelt werden. Mit Ausnahme der Kommunikationswege decken die Faktoren sich mit denen der Privatwirtschaft. Die öffentliche Verwaltung ist dazu angehalten, den aktuellen Ausprägungsgrad der Amtshierarchie kritisch zu hinterfragen, um das volle Potential des Social - Media - Personalmarketings zukünftig zu heben.
A novel common variant in DCST2 is associated with length in early life and height in adulthood
(2015)
Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 x 10(-6)) for birth length, of which three were novel and four were in or near loci known to be associated with adult height (LCORL, PTCH1, GPR126 and HMGA2). The three novel SNPs were followed-up in nine replication studies (Stage 2; N = 11 995), with rs905938 in DC-STAMP domain containing 2 (DCST2) genome-wide significantly associated with birth length in a joint analysis (Stages 1 + 2; beta = 0.046, SE = 0.008, P = 2.46 x 10(-8), explained variance = 0.05%). Rs905938 was also associated with infant length (N = 28 228; P = 5.54 x 10(-4)) and adult height (N = 127 513; P = 1.45 x 10(-5)). DCST2 is a DC-STAMP-like protein family member and DC-STAMP is an osteoclast cell-fusion regulator. Polygenic scores based on 180 SNPs previously associated with human adult stature explained 0.13% of variance in birth length. The same SNPs explained 2.95% of the variance of infant length. Of the 180 known adult height loci, 11 were genome-wide significantly associated with infant length (SF3B4, LCORL, SPAG17, C6orf173, PTCH1, GDF5, ZNFX1, HHIP, ACAN, HLA locus and HMGA2). This study highlights that common variation in DCST2 influences variation in early growth and adult height.