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We have analyzed the recently developed pan-European strong motion database, RESORCE-2012: spectral parameters, such as stress drop (stress parameter, Delta sigma), anelastic attenuation (Q), near surface attenuation (kappa(0)) and site amplification have been estimated from observed strong motion recordings. The selected dataset exhibits a bilinear distance-dependent Q model with average kappa(0) value 0.0308 s. Strong regional variations in inelastic attenuation were also observed: frequency-independent Q(0) of 1462 and 601 were estimated for Turkish and Italian data respectively. Due to the strong coupling between Q and kappa(0), the regional variations in Q have strong impact on the estimation of near surface attenuation kappa(0). kappa(0) was estimated as 0.0457 and 0.0261 s for Turkey and Italy respectively. Furthermore, a detailed analysis of the variability in estimated kappa(0) revealed significant within-station variability. The linear site amplification factors were constrained from residual analysis at each station and site-class type. Using the regional Q(0) model and a site-class specific kappa(0), seismic moments (M-0) and source corner frequencies f (c) were estimated from the site corrected empirical Fourier spectra. Delta sigma did not exhibit magnitude dependence. The median Delta sigma value was obtained as 5.75 and 5.65 MPa from inverted and database magnitudes respectively. A comparison of response spectra from the stochastic model (derived herein) with that from (regional) ground motion prediction equations (GMPEs) suggests that the presented seismological parameters can be used to represent the corresponding seismological attributes of the regional GMPEs in a host-to-target adjustment framework. The analysis presented herein can be considered as an update of that undertaken for the previous Euro-Mediterranean strong motion database presented by Edwards and Fah (Geophys J Int 194(2):1190-1202, 2013a).
Early agriculture can be detected in palaeovegetation records, but quantification of the relative importance of climate and land use in influencing regional vegetation composition since the onset of agriculture is a topic that is rarely addressed. We present a novel approach that combines pollen-based REVEALS estimates of plant cover with climate, anthropogenic land-cover and dynamic vegetation modelling results. This is used to quantify the relative impacts of land use and climate on Holocene vegetation at a sub-continental scale, i.e. northern and western Europe north of the Alps. We use redundancy analysis and variation partitioning to quantify the percentage of variation in vegetation composition explained by the climate and land-use variables, and Monte Carlo permutation tests to assess the statistical significance of each variable. We further use a similarity index to combine pollen based REVEALS estimates with climate-driven dynamic vegetation modelling results. The overall results indicate that climate is the major driver of vegetation when the Holocene is considered as a whole and at the sub-continental scale, although land use is important regionally. Four critical phases of land-use effects on vegetation are identified. The first phase (from 7000 to 6500 BP) corresponds to the early impacts on vegetation of farming and Neolithic forest clearance and to the dominance of climate as a driver of vegetation change. During the second phase (from 4500 to 4000 BP), land use becomes a major control of vegetation. Climate is still the principal driver, although its influence decreases gradually. The third phase (from 2000 to 1500 BP) is characterised by the continued role of climate on vegetation as a consequence of late-Holocene climate shifts and specific climate events that influence vegetation as well as land use. The last phase (from 500 to 350 BP) shows an acceleration of vegetation changes, in particular during the last century, caused by new farming practices and forestry in response to population growth and industrialization. This is a unique signature of anthropogenic impact within the Holocene but European vegetation remains climatically sensitive and thus may continue to respond to ongoing climate change. (C) 2017 Elsevier Ltd. All rights reserved.
Empirical ground-motion prediction equations (GMPEs) require adjustment to make them appropriate for site-specific scenarios. However, the process of making such adjustments remains a challenge. This article presents a holistic framework for the development of a response spectral GMPE that is easily adjustable to different seismological conditions and does not suffer from the practical problems associated with adjustments in the response spectral domain. The approach for developing a response spectral GMPE is unique, because it combines the predictions of empirical models for the two model components that characterize the spectral and temporal behavior of the ground motion. Essentially, as described in its initial form by Bora et al. (2014), the approach consists of an empirical model for the Fourier amplitude spectrum (FAS) and a model for the ground-motion duration. These two components are combined within the random vibration theory framework to obtain predictions of response spectral ordinates. In addition, FAS corresponding to individual acceleration records are extrapolated beyond the useable frequencies using the stochastic FAS model, obtained by inversion as described in Edwards and Fah (2013a). To that end, a (oscillator) frequency-dependent duration model, consistent with the empirical FAS model, is also derived. This makes it possible to generate a response spectral model that is easily adjustable to different sets of seismological parameters, such as the stress parameter Delta sigma, quality factor Q, and kappa kappa(0). The dataset used in Bora et al. (2014), a subset of the RESORCE-2012 database, is considered for the present analysis. Based upon the range of the predictor variables in the selected dataset, the present response spectral GMPE should be considered applicable over the magnitude range of 4 <= M-w <= 7.6 at distances <= 200 km.
A catalog of genetic loci associated with kidney function from analyses of a million individuals
(2019)
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.