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- Shayduk, M. (1)
- Sheidaei, F. (1)
- Shepherd, John A. (1)
- Shiningayamwe, K. (1)
- Shore, S. N. (1)
- Sillanpaa, A. (1)
- Simoni, R. (1)
- Simpson, Angela (1)
- Sinha, A. (1)
- Sitarek, J. (1)
- Skilton, J. L. (1)
- Skotte, Line (1)
- Sleiman, Patrick M. A. (1)
- Smith, George Davey (1)
- Snieder, Harold (1)
- Sobczynska, D. (1)
- Sorensen, Thorkild I. A. (1)
- Spanier, F. (1)
- Specovius, A. (1)
- Spencer, S. (1)
- Spengler, G. (1)
- Spir-Jacob, M. (1)
- Spiro, S. (1)
- St Pourcain, Beate (1)
- Stamerra, A. (1)
- Standl, Marie (1)
- Steegers, Eric A. P. (1)
- Steele, I. A. (1)
- Stegmann, C. (1)
- Stegmann, Christian (1)
- Steinke, B. (1)
- Steinmassl, S. (1)
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- Sun, L. (1)
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- Takahashi, T. (1)
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- Tavernet, J. -P. (1)
- Tavernier, T. (1)
- Taylor, A. M. (1)
- Taylor, Michelle (1)
- Telezhinsky, Igor O. (1)
- Temnikov, P. (1)
- Teo, Yik-Ying (1)
- Terzic, T. (1)
- Tescaro, D. (1)
- Teshima, M. (1)
- Tesic, G. (1)
- Theiling, M. (1)
- Thibadeau, S. (1)
- Thiering, Elisabeth (1)
- Thom, M. (1)
- Tibolla, O. (1)
- Tiemeier, Henning (1)
- Timpson, Nicholas J. (1)
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- Torres, D. F. (1)
- Treves, A. (1)
- Trichard, C. (1)
- Tridon, D. Borla (1)
- Tsirou, M. (1)
- Tuffs, R. (1)
- Tyrrell, Jessica (1)
- Uchiyama, Y. (1)
- Uitterlinden, Andre G. (1)
- Valerius, K. (1)
- Vankov, H. (1)
- Varlotta, A. (1)
- Vassiliev, V. V. (1)
- Veh, J. (1)
- Vialle, J. P. (1)
- Viana, A. (1)
- Viikari, Jorma (1)
- Vilor-Tejedor, Natalia (1)
- Vink, J. (1)
- Vivier, M. (1)
- Voelk, H. J. (1)
- Vogelezang, Suzanne (1)
- Vogler, P. (1)
- Volk, H. J. (1)
- Volpe, F. (1)
- Vonk, Judith M. (1)
- Vorobiov, S. (1)
- Vorster, M. (1)
- Vrijkotte, Tanja G. M. (1)
- Vuillaume, T. (1)
- Vuoksimaa, Eero (1)
- Wadiasingh, Z. (1)
- Wagner, R. M. (1)
- Wakely, S. P. (1)
- Walker, R. C. (1)
- Wang, Carol A. (1)
- Ward, M. (1)
- Warrington, Nicole M. (1)
- Watkins, William J. (1)
- Watson, J. (1)
- Weekes, T. C. (1)
- Weitzel, Q. (1)
- Werner, F. (1)
- Whitehouse, Andrew J. O. (1)
- Wichmann, H-Erich (1)
- Widen, Elisabeth E. (1)
- Willemsen, Gonneke (1)
- Williams, Charlotte K. (1)
- Williams, D. A. (1)
- Williams, Gail M. (1)
- Wilson, James F. (1)
- Wong, Yu Wun (1)
- Wood, D. L. (1)
- Wray, Naomi R. (1)
- Xu, Cheng-Jian (1)
- Xu, Shujing (1)
- Yaghootkar, Hanieh (1)
- Yi, Lu (1)
- Yusafzai, A. (1)
- Zabalza, V. (1)
- Zafarmand, Mohammad Hadi (1)
- Zajczyk, A. (1)
- Zandanel, F. (1)
- Zargaryan, D. (1)
- Zechlin, H. -S. (1)
- Zeggini, Eleftheria (1)
- Zemel, Babette S. (1)
- Zhu, S. J. (1)
- Ziegler, A. (1)
- Zitzer, B. (1)
- Zorn, J. (1)
- Zouari, S. (1)
- Zywucka, N. (1)
- de Almeida, U. Barres (1)
- de Clairfontaine, G. Fichet (1)
- de Jager, O. C. (1)
- de Lavergne, M. de Bony (1)
- de los Reyes, R. (1)
- deWilt, P. (1)
- van Beijsterveldt, Toos (1)
- van Duijn, Cornelia M. (1)
- van Rensburg, C. (1)
- van Soelen, B. (1)
- van der Most, Peter J. (1)
- van der Walt, D. J. (1)
Language
- English (5)
Keywords
- Childhood traits and disorders (1)
- Consortium (1)
- Genetics (1)
- ISM (1)
- ISM: clouds (1)
- ISM: supernova remnants (1)
- Longitudinal (1)
- galaxies: active (1)
- galaxies: individual (M 87) (1)
- galaxies: jets (1)
- galaxies: nuclei (1)
- gamma rays: (1)
- gamma rays: galaxies (1)
- gamma rays: general (1)
- radiation mechanisms: non-thermal (1)
Institute
The 2010 very high energy gamma-ray flare and 10 years ofmulti-wavelength oservations of M 87
(2012)
Abramowski, Attila ; Acero, F. ; Aharonian, Felix A. ; Akhperjanian, A. G. ; Anton, Gisela ; Balzer, Arnim ; Barnacka, Anna ; de Almeida, U. Barres ; Becherini, Yvonne ; Becker, J. ; Behera, B. ; Bernlöhr, K. ; Birsin, E. ; Biteau, Jonathan ; Bochow, A. ; Boisson, Catherine ; Bolmont, J. ; Bordas, Pol ; Brucker, J. ; Brun, Francois ; Brun, Pierre ; Bulik, Tomasz ; Buesching, I. ; Carrigan, Svenja ; Casanova, Sabrina ; Cerruti, M. ; Chadwick, Paula M. ; Charbonnier, A. ; Chaves, Ryan C. G. ; Cheesebrough, A. ; Clapson, A. C. ; Coignet, G. ; Cologna, Gabriele ; Conrad, Jan ; Dalton, M. ; Daniel, M. K. ; Davids, I. D. ; Degrange, B. ; Deil, C. ; Dickinson, H. J. ; Djannati-Ataï, A. ; Domainko, W. ; Drury, L. O'C. ; Dubus, G. ; Dutson, K. ; Dyks, J. ; Dyrda, M. ; Egberts, Kathrin ; Eger, P. ; Espigat, P. ; Fallon, L. ; Farnier, C. ; Fegan, S. ; Feinstein, F. ; Fernandes, M. V. ; Fiasson, A. ; Fontaine, G. ; Foerster, A. ; Fuessling, M. ; Gallant, Y. A. ; Gast, H. ; Gerard, L. ; Gerbig, D. ; Giebels, B. ; Glicenstein, J. F. ; Glueck, B. ; Goret, P. ; Goering, D. ; Haeffner, S. ; Hague, J. D. ; Hampf, D. ; Hauser, M. ; Heinz, S. ; Heinzelmann, G. ; Henri, G. ; Hermann, G. ; Hinton, James Anthony ; Hoffmann, A. ; Hofmann, W. ; Hofverberg, P. ; Holler, M. ; Horns, D. ; Jacholkowska, A. ; de Jager, O. C. ; Jahn, C. ; Jamrozy, M. ; Jung, I. ; Kastendieck, M. A. ; Katarzynski, K. ; Katz, U. ; Kaufmann, S. ; Keogh, D. ; Khangulyan, D. ; Khelifi, B. ; Klochkov, D. ; Kluzniak, W. ; Kneiske, T. ; Komin, Nu. ; Kosack, K. ; Kossakowski, R. ; Laffon, H. ; Lamanna, G. ; Lennarz, D. ; Lohse, T. ; Lopatin, A. ; Lu, C. -C. ; Marandon, V. ; Marcowith, Alexandre ; Masbou, J. ; Maurin, D. ; Maxted, N. ; Mayer, M. ; McComb, T. J. L. ; Medina, M. C. ; Mehault, J. ; Moderski, R. ; Moulin, Emmanuel ; Naumann, C. L. ; Naumann-Godo, M. ; de Naurois, M. ; Nedbal, D. ; Nekrassov, D. ; Nguyen, N. ; Nicholas, B. ; Niemiec, J. ; Nolan, S. J. ; Ohm, S. ; Wilhelmi, E. de Ona ; Opitz, B. ; Ostrowski, M. ; Oya, I. ; Panter, M. ; Arribas, M. Paz ; Pedaletti, G. ; Pelletier, G. ; Petrucci, P. -O. ; Pita, S. ; Puehlhofer, G. ; Punch, M. ; Quirrenbach, A. ; Raue, M. ; Rayner, S. M. ; Reimer, A. ; Reimer, O. ; Renaud, M. ; de los Reyes, R. ; Rieger, F. ; Ripken, J. ; Rob, L. ; Rosier-Lees, S. ; Rowell, G. ; Rudak, B. ; Rulten, C. B. ; Ruppel, J. ; Sahakian, V. ; Sanchez, David M. ; Santangelo, Andrea ; Schlickeiser, R. ; Schoeck, F. M. ; Schulz, A. ; Schwanke, U. ; Schwarzburg, S. ; Schwemmer, S. ; Sheidaei, F. ; Skilton, J. L. ; Sol, H. ; Spengler, G. ; Stawarz, L. ; Steenkamp, R. ; Stegmann, Christian ; Stinzing, F. ; Stycz, K. ; Sushch, Iurii ; Szostek, A. ; Tavernet, J. -P. ; Terrier, R. ; Tluczykont, M. ; Valerius, K. ; van Eldik, C. ; Vasileiadis, G. ; Venter, C. ; Vialle, J. P. ; Viana, A. ; Vincent, P. ; Voelk, H. J. ; Volpe, F. ; Vorobiov, S. ; Vorster, M. ; Wagner, S. J. ; Ward, M. ; White, R. ; Wierzcholska, A. ; Zacharias, M. ; Zajczyk, A. ; Zdziarski, A. A. ; Zech, Alraune ; Zechlin, H. -S. ; Aleksic, J. ; Antonelli, L. A. ; Antoranz, P. ; Backes, Michael ; Barrio, J. A. ; Bastieri, D. ; Becerra Gonzalez, J. ; Bednarek, W. ; Berdyugin, A. ; Berger, K. ; Bernardini, E. ; Biland, A. ; Blanch Bigas, O. ; Bock, R. K. ; Boller, A. ; Bonnoli, G. ; Tridon, D. Borla ; Braun, I. ; Bretz, T. ; Canellas, A. ; Carmona, E. ; Carosi, A. ; Colin, P. ; Colombo, E. ; Contreras, J. L. ; Cortina, J. ; Cossio, L. ; Covino, S. ; Dazzi, F. ; De Angelis, A. ; De Cea del Pozo, E. ; De Lotto, B. ; Delgado Mendez, C. ; Diago Ortega, A. ; Doert, M. ; Dominguez, A. ; Prester, Dijana Dominis ; Dorner, D. ; Doro, M. ; Elsaesser, D. ; Ferenc, D. ; Fonseca, M. V. ; Font, L. ; Fruck, C. ; Garcia Lopez, R. J. ; Garczarczyk, M. ; Garrido, D. ; Giavitto, G. ; Godinovic, N. ; Hadasch, D. ; Haefner, D. ; Herrero, A. ; Hildebrand, D. ; Hoehne-Moench, D. ; Hose, J. ; Hrupec, D. ; Huber, B. ; Jogler, T. ; Klepser, S. ; Kraehenbuehl, T. ; Krause, J. ; La Barbera, A. ; Lelas, D. ; Leonardo, E. ; Lindfors, E. ; Lombardi, S. ; Lopez, M. ; Lorenz, E. ; Makariev, M. ; Maneva, G. ; Mankuzhiyil, N. ; Mannheim, K. ; Maraschi, L. ; Mariotti, M. ; Martinez, M. ; Mazin, D. ; Meucci, M. ; Miranda, J. M. ; Mirzoyan, R. ; Miyamoto, H. ; Moldon, J. ; Moralejo, A. ; Munar, P. ; Nieto, D. ; Nilsson, K. ; Orito, R. ; Oya, I. ; Paneque, D. ; Paoletti, R. ; Pardo, S. ; Paredes, J. M. ; Partini, S. ; Pasanen, M. ; Pauss, F. ; Perez-Torres, M. A. ; Persic, M. ; Peruzzo, L. ; Pilia, M. ; Pochon, J. ; Prada, F. ; Moroni, P. G. Prada ; Prandini, E. ; Puljak, I. ; Reichardt, I. ; Reinthal, R. ; Rhode, W. ; Ribo, M. ; Rico, J. ; Ruegamer, S. ; Saggion, A. ; Saito, K. ; Saito, T. Y. ; Salvati, M. ; Satalecka, K. ; Scalzotto, V. ; Scapin, V. ; Schultz, C. ; Schweizer, T. ; Shayduk, M. ; Shore, S. N. ; Sillanpaa, A. ; Sitarek, J. ; Sobczynska, D. ; Spanier, F. ; Spiro, S. ; Stamerra, A. ; Steinke, B. ; Storz, J. ; Strah, N. ; Suric, T. ; Takalo, L. ; Takami, H. ; Tavecchio, F. ; Temnikov, P. ; Terzic, T. ; Tescaro, D. ; Teshima, M. ; Thom, M. ; Tibolla, O. ; Torres, D. F. ; Treves, A. ; Vankov, H. ; Vogler, P. ; Wagner, R. M. ; Weitzel, Q. ; Zabalza, V. ; Zandanel, F. ; Zanin, R. ; Arlen, T. ; Aune, T. ; Beilicke, M. ; Benbow, W. ; Bouvier, A. ; Bradbury, S. M. ; Buckley, J. H. ; Bugaev, V. ; Byrum, K. ; Cannon, A. ; Cesarini, A. ; Ciupik, L. ; Connolly, M. P. ; Cui, W. ; Dickherber, R. ; Duke, C. ; Errando, M. ; Falcone, A. ; Finley, J. P. ; Finnegan, G. ; Fortson, L. ; Furniss, A. ; Galante, N. ; Gall, D. ; Godambe, S. ; Griffin, S. ; Grube, J. ; Gyuk, G. ; Hanna, D. ; Holder, J. ; Huan, H. ; Hui, C. M. ; Kaaret, P. ; Karlsson, N. ; Kertzman, M. ; Khassen, Y. ; Kieda, D. ; Krawczynski, H. ; Krennrich, F. ; Lang, M. J. ; LeBohec, S. ; Maier, G. ; McArthur, S. ; McCann, A. ; Moriarty, P. ; Mukherjee, R. ; Nunez, P. D. ; Ong, R. A. ; Orr, M. ; Otte, A. N. ; Park, N. ; Perkins, J. S. ; Pichel, A. ; Pohl, Martin ; Prokoph, H. ; Ragan, K. ; Reyes, L. C. ; Reynolds, P. T. ; Roache, E. ; Rose, H. J. ; Ruppel, J. ; Schroedter, M. ; Sembroski, G. H. ; Sentuerk, G. D. ; Telezhinsky, Igor O. ; Tesic, G. ; Theiling, M. ; Thibadeau, S. ; Varlotta, A. ; Vassiliev, V. V. ; Vivier, M. ; Wakely, S. P. ; Weekes, T. C. ; Williams, D. A. ; Zitzer, B. ; de Almeida, U. Barres ; Cara, M. ; Casadio, C. ; Cheung, C. C. ; McConville, W. ; Davies, F. ; Doi, A. ; Giovannini, G. ; Giroletti, M. ; Hada, K. ; Hardee, P. ; Harris, D. E. ; Junor, W. ; Kino, M. ; Lee, N. P. ; Ly, C. ; Madrid, J. ; Massaro, F. ; Mundell, C. G. ; Nagai, H. ; Perlman, E. S. ; Steele, I. A. ; Walker, R. C. ; Wood, D. L.
The giant radio galaxy M 87 with its proximity (16 Mpc), famous jet, and very massive black hole ((3-6) x 10(9) M-circle dot) provides a unique opportunity to investigate the origin of very high energy (VHE; E > 100 GeV) gamma-ray emission generated in relativistic outflows and the surroundings of supermassive black holes. M 87 has been established as a VHE gamma-ray emitter since 2006. The VHE gamma-ray emission displays strong variability on timescales as short as a day. In this paper, results from a joint VHE monitoring campaign on M 87 by the MAGIC and VERITAS instruments in 2010 are reported. During the campaign, a flare at VHE was detected triggering further observations at VHE (H.E.S.S.), X-rays (Chandra), and radio (43 GHz Very Long Baseline Array, VLBA). The excellent sampling of the VHE gamma-ray light curve enables one to derive a precise temporal characterization of the flare: the single, isolated flare is well described by a two-sided exponential function with significantly different flux rise and decay times of tau(rise)(d) = (1.69 +/- 0.30) days and tau(decay)(d) = (0.611 +/- 0.080) days, respectively. While the overall variability pattern of the 2010 flare appears somewhat different from that of previous VHE flares in 2005 and 2008, they share very similar timescales (similar to day), peak fluxes (Phi(>0.35 TeV) similar or equal to (1-3) x 10(-11) photons cm(-2) s(-1)), and VHE spectra. VLBA radio observations of 43 GHz of the inner jet regions indicate no enhanced flux in 2010 in contrast to observations in 2008, where an increase of the radio flux of the innermost core regions coincided with a VHE flare. On the other hand, Chandra X-ray observations taken similar to 3 days after the peak of the VHE gamma-ray emission reveal an enhanced flux from the core (flux increased by factor similar to 2; variability timescale <2 days). The long-term (2001-2010) multi-wavelength (MWL) light curve of M 87, spanning from radio to VHE and including data from Hubble Space Telescope, Liverpool Telescope, Very Large Array, and European VLBI Network, is used to further investigate the origin of the VHE gamma-ray emission. No unique, common MWL signature of the three VHE flares has been identified. In the outer kiloparsec jet region, in particular in HST-1, no enhanced MWL activity was detected in 2008 and 2010, disfavoring it as the origin of the VHE flares during these years. Shortly after two of the three flares (2008 and 2010), the X-ray core was observed to be at a higher flux level than its characteristic range (determined from more than 60 monitoring observations: 2002-2009). In 2005, the strong flux dominance of HST-1 could have suppressed the detection of such a feature. Published models for VHE gamma-ray emission from M 87 are reviewed in the light of the new data.
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia
(2019)
Middeldorp, Christel M. ; Mahajan, Anubha ; Horikoshi, Momoko ; Robertson, Neil R. ; Beaumont, Robin N. ; Bradfield, Jonathan P. ; Bustamante, Mariona ; Cousminer, Diana L. ; Day, Felix R. ; De Silva, N. Maneka ; Guxens, Monica ; Mook-Kanamori, Dennis O. ; St Pourcain, Beate ; Warrington, Nicole M. ; Adair, Linda S. ; Ahlqvist, Emma ; Ahluwalia, Tarunveer Singh ; Almgren, Peter ; Ang, Wei ; Atalay, Mustafa ; Auvinen, Juha ; Bartels, Meike ; Beckmann, Jacques S. ; Bilbao, Jose Ramon ; Bond, Tom ; Borja, Judith B. ; Cavadino, Alana ; Charoen, Pimphen ; Chen, Zhanghua ; Coin, Lachlan ; Cooper, Cyrus ; Curtin, John A. ; Custovic, Adnan ; Das, Shikta ; Davies, Gareth E. ; Dedoussis, George V. ; Duijts, Liesbeth ; Eastwood, Peter R. ; Eliasen, Anders U. ; Elliott, Paul ; Eriksson, Johan G. ; Estivill, Xavier ; Fadista, Joao ; Fedko, Iryna O. ; Frayling, Timothy M. ; Gaillard, Romy ; Gauderman, W. James ; Geller, Frank ; Gilliland, Frank ; Gilsanz, Vincente ; Granell, Raquel ; Grarup, Niels ; Groop, Leif ; Hadley, Dexter ; Hakonarson, Hakon ; Hansen, Torben ; Hartman, Catharina A. ; Hattersley, Andrew T. ; Hayes, M. Geoffrey ; Hebebrand, Johannes ; Heinrich, Joachim ; Helgeland, Oyvind ; Henders, Anjali K. ; Henderson, John ; Henriksen, Tine B. ; Hirschhorn, Joel N. ; Hivert, Marie-France ; Hocher, Berthold ; Holloway, John W. ; Holt, Patrick ; Hottenga, Jouke-Jan ; Hypponen, Elina ; Iniguez, Carmen ; Johansson, Stefan ; Jugessur, Astanand ; Kahonen, Mika ; Kalkwarf, Heidi J. ; Kaprio, Jaakko ; Karhunen, Ville ; Kemp, John P. ; Kerkhof, Marjan ; Koppelman, Gerard H. ; Korner, Antje ; Kotecha, Sailesh ; Kreiner-Moller, Eskil ; Kulohoma, Benard ; Kumar, Ashish ; Kutalik, Zoltan ; Lahti, Jari ; Lappe, Joan M. ; Larsson, Henrik ; Lehtimaki, Terho ; Lewin, Alexandra M. ; Li, Jin ; Lichtenstein, Paul ; Lindgren, Cecilia M. ; Lindi, Virpi ; Linneberg, Allan ; Liu, Xueping ; Liu, Jun ; Lowe, William L. ; Lundstrom, Sebastian ; Lyytikainen, Leo-Pekka ; Ma, Ronald C. W. ; Mace, Aurelien ; Magi, Reedik ; Magnus, Per ; Mamun, Abdullah A. ; Mannikko, Minna ; Martin, Nicholas G. ; Mbarek, Hamdi ; McCarthy, Nina S. ; Medland, Sarah E. ; Melbye, Mads ; Melen, Erik ; Mohlke, Karen L. ; Monnereau, Claire ; Morgen, Camilla S. ; Morris, Andrew P. ; Murray, Jeffrey C. ; Myhre, Ronny ; Najman, Jackob M. ; Nivard, Michel G. ; Nohr, Ellen A. ; Nolte, Ilja M. ; Ntalla, Ioanna ; Oberfield, Sharon E. ; Oken, Emily ; Oldehinkel, Albertine J. ; Pahkala, Katja ; Palviainen, Teemu ; Panoutsopoulou, Kalliope ; Pedersen, Oluf ; Pennell, Craig E. ; Pershagen, Goran ; Pitkanen, Niina ; Plomin, Robert ; Power, Christine ; Prasad, Rashmi B. ; Prokopenko, Inga ; Pulkkinen, Lea ; Raikkonen, Katri ; Raitakari, Olli T. ; Reynolds, Rebecca M. ; Richmond, Rebecca C. ; Rivadeneira, Fernando ; Rodriguez, Alina ; Rose, Richard J. ; Salem, Rany ; Santa-Marina, Loreto ; Saw, Seang-Mei ; Schnurr, Theresia M. ; Scott, James G. ; Selzam, Saskia ; Shepherd, John A. ; Simpson, Angela ; Skotte, Line ; Sleiman, Patrick M. A. ; Snieder, Harold ; Sorensen, Thorkild I. A. ; Standl, Marie ; Steegers, Eric A. P. ; Strachan, David P. ; Straker, Leon ; Strandberg, Timo ; Taylor, Michelle ; Teo, Yik-Ying ; Thiering, Elisabeth ; Torrent, Maties ; Tyrrell, Jessica ; Uitterlinden, Andre G. ; van Beijsterveldt, Toos ; van der Most, Peter J. ; van Duijn, Cornelia M. ; Viikari, Jorma ; Vilor-Tejedor, Natalia ; Vogelezang, Suzanne ; Vonk, Judith M. ; Vrijkotte, Tanja G. M. ; Vuoksimaa, Eero ; Wang, Carol A. ; Watkins, William J. ; Wichmann, H-Erich ; Willemsen, Gonneke ; Williams, Gail M. ; Wilson, James F. ; Wray, Naomi R. ; Xu, Shujing ; Xu, Cheng-Jian ; Yaghootkar, Hanieh ; Yi, Lu ; Zafarmand, Mohammad Hadi ; Zeggini, Eleftheria ; Zemel, Babette S. ; Hinney, Anke ; Lakka, Timo A. ; Whitehouse, Andrew J. O. ; Sunyer, Jordi ; Widen, Elisabeth E. ; Feenstra, Bjarke ; Sebert, Sylvain ; Jacobsson, Bo ; Njolstad, Pal R. ; Stoltenberg, Camilla ; Smith, George Davey ; Lawlor, Debbie A. ; Paternoster, Lavinia ; Timpson, Nicholas J. ; Ong, Ken K. ; Bisgaard, Hans ; Bonnelykke, Klaus ; Jaddoe, Vincent W. V. ; Tiemeier, Henning ; Jarvelin, Marjo-Riitta ; Evans, David M. ; Perry, John R. B. ; Grant, Struan F. A. ; Boomsma, Dorret I. ; Freathy, Rachel M. ; McCarthy, Mark I. ; Felix, Janine F.
The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.
Abdalla, H. ; Adam, R. ; Aharonian, Felix A. ; Benkhali, F. Ait ; Angüner, Ekrem Oǧuzhan ; Arcaro, C. ; Armand, C. ; Armstrong, T. ; Ashkar, H. ; Backes, M. ; Baghmanyan, V. ; Martins, V. Barbosa ; Barnacka, A. ; Barnard, M. ; Becherini, Y. ; Berge, D. ; Bernlohr, K. ; Bi, B. ; Bottcher, M. ; Boisson, C. ; Bolmont, J. ; de Lavergne, M. de Bony ; Bordas, Pol ; Breuhaus, M. ; Brun, F. ; Brun, P. ; Bryan, M. ; Buchele, M. ; Bulik, T. ; Bylund, T. ; Caroff, S. ; Carosi, A. ; Casanova, Sabrina ; Chand, T. ; Chandra, S. ; Chen, A. ; Cotter, G. ; Curylo, M. ; Mbarubucyeye, J. Damascene ; Davids, I. D. ; Davies, J. ; Deil, C. ; Devin, J. ; deWilt, P. ; Dirson, L. ; Djannati-Atai, A. ; Dmytriiev, A. ; Donath, A. ; Doroshenko, V. ; Duffy, C. ; Dyks, J. ; Egberts, Kathrin ; Eichhorn, F. ; Einecke, S. ; Emery, G. ; Ernenwein, J. -P. ; Feijen, K. ; Fegan, S. ; Fiasson, A. ; de Clairfontaine, G. Fichet ; Fontaine, G. ; Funk, S. ; Fussling, Matthias ; Gabici, S. ; Gallant, Y. A. ; Giavitto, G. ; Giunti, L. ; Glawion, D. ; Glicenstein, J. F. ; Gottschall, D. ; Grondin, M. -H. ; Hahn, J. ; Haupt, M. ; Hermann, G. ; Hinton, J. A. ; Hofmann, W. ; Hoischen, Clemens ; Holch, T. L. ; Holler, M. ; Horbe, M. ; Horns, D. ; Huber, D. ; Jamrozy, M. ; Jankowsky, D. ; Jankowsky, F. ; Jardin-Blicq, A. ; Joshi, V. ; Jung-Richardt, I. ; Kasai, E. ; Kastendieck, M. A. ; Katarzynski, K. ; Katz, U. ; Khangulyan, D. ; Khelifi, B. ; Klepser, S. ; Kluzniak, W. ; Komin, Nu. ; Konno, R. ; Kosack, K. ; Kostunin, D. ; Kreter, M. ; Lamanna, G. ; Lemiere, A. ; Lemoine-Goumard, M. ; Lenain, J. -P. ; Levy, C. ; Lohse, T. ; Lypova, I. ; Mackey, J. ; Majumdar, J. ; Malyshev, D. ; Malyshev, D. ; Marandon, V. ; Marchegiani, P. ; Marcowith, Alexandre ; Mares, A. ; Marti-Devesa, G. ; Marx, R. ; Maurin, G. ; Meintjes, P. J. ; Meyer, M. ; Mitchell, A. ; Moderski, R. ; Mohamed, M. ; Mohrmann, L. ; Montanari, A. ; Moore, C. ; Morris, P. ; Moulin, Emmanuel ; Muller, J. ; Murach, T. ; Nakashima, K. ; Nayerhoda, A. ; de Naurois, M. ; Ndiyavala, H. ; Niederwanger, F. ; Niemiec, J. ; Oakes, L. ; O'Brien, Patrick ; Odaka, H. ; Ohm, S. ; Olivera-Nieto, L. ; Wilhelmi, E. de Ona ; Ostrowski, M. ; Oya, I. ; Panter, M. ; Panny, S. ; Parsons, R. D. ; Peron, G. ; Peyaud, B. ; Piel, Q. ; Pita, S. ; Poireau, V. ; Noel, A. Priyana ; Prokhorov, D. A. ; Prokoph, H. ; Puhlhofer, G. ; Punch, M. ; Quirrenbach, A. ; Raab, S. ; Rauth, R. ; Reichherzer, P. ; Reimer, A. ; Reimer, O. ; Remy, Q. ; Renaud, M. ; Rieger, F. ; Rinchiuso, L. ; Romoli, C. ; Rowell, G. ; Rudak, B. ; Ruiz-Velasco, E. ; Sahakian, V. ; Sailer, S. ; Sanchez, D. A. ; Santangelo, Andrea ; Sasaki, M. ; Scalici, M. ; Schussler, F. ; Schutte, H. M. ; Schwanke, U. ; Schwemmer, S. ; Seglar-Arroyo, M. ; Senniappan, M. ; Seyffert, A. S. ; Shafi, N. ; Shiningayamwe, K. ; Simoni, R. ; Sinha, A. ; Sol, H. ; Specovius, A. ; Spencer, S. ; Spir-Jacob, M. ; Stawarz, L. ; Sun, L. ; Steenkamp, R. ; Stegmann, C. ; Steinmassl, S. ; Steppa, C. ; Takahashi, T. ; Tavernier, T. ; Taylor, A. M. ; Terrier, R. ; Tiziani, D. ; Tluczykont, M. ; Tomankova, L. ; Trichard, C. ; Tsirou, M. ; Tuffs, R. ; Uchiyama, Y. ; van der Walt, D. J. ; van Eldik, C. ; van Rensburg, C. ; van Soelen, B. ; Vasileiadis, G. ; Veh, J. ; Venter, C. ; Vincent, P. ; Vink, J. ; Volk, H. J. ; Vuillaume, T. ; Wadiasingh, Z. ; Wagner, S. J. ; Watson, J. ; Werner, F. ; White, R. ; Wierzcholska, A. ; Wong, Yu Wun ; Yusafzai, A. ; Zacharias, M. ; Zanin, R. ; Zargaryan, D. ; Zdziarski, A. A. ; Zech, Alraune ; Zhu, S. J. ; Ziegler, A. ; Zorn, J. ; Zouari, S. ; Zywucka, N.
The unidentified very-high-energy (VHE; E > 0.1 TeV) gamma -ray source, HESS J1826-130, was discovered with the High Energy Stereoscopic System (HESS) in the Galactic plane. The analysis of 215 h of HESS data has revealed a steady gamma -ray flux from HESS J1826-130, which appears extended with a half-width of 0.21 degrees +/- 0.02 <br /> (stat)degrees <br /> stat degrees +/- 0.05 <br /> (sys)degrees sys degrees . The source spectrum is best fit with either a power-law function with a spectral index Gamma = 1.78 +/- 0.10(stat) +/- 0.20(sys) and an exponential cut-off at 15.2 <br /> (+5.5)(-3.2) -3.2+5.5 TeV, or a broken power-law with Gamma (1) = 1.96 +/- 0.06(stat) +/- 0.20(sys), Gamma (2) = 3.59 +/- 0.69(stat) +/- 0.20(sys) for energies below and above E-br = 11.2 +/- 2.7 TeV, respectively. The VHE flux from HESS J1826-130 is contaminated by the extended emission of the bright, nearby pulsar wind nebula, HESS J1825-137, particularly at the low end of the energy spectrum. Leptonic scenarios for the origin of HESS J1826-130 VHE emission related to PSR J1826-1256 are confronted by our spectral and morphological analysis. In a hadronic framework, taking into account the properties of dense gas regions surrounding HESS J1826-130, the source spectrum would imply an astrophysical object capable of accelerating the parent particle population up to greater than or similar to 200 TeV. Our results are also discussed in a multiwavelength context, accounting for both the presence of nearby supernova remnants, molecular clouds, and counterparts detected in radio, X-rays, and TeV energies.
Sandee, A. J. ; Williams, Charlotte K. ; Evans, N. R. ; Davies, J. E. ; Boothby, C. E. ; Köhler, Anna ; Friend, Richard H. ; Holmes, Andrew B.
The development of phonetic codes in memory of 141 pairs of normal and disabled readers from 7.8 to 16.8 years of age was tested with a task adapted from L. S. Mark, D. Shankweiler, I. Y. Liberman, and C. A. Fowler (Memory & Cognition, 1977, 5, 623–629) that measured false-positive errors in recognition memory for foil words which rhymed with words in the memory list versus foil words that did not rhyme. Our younger subjects replicated Mark et al., showing a larger difference between rhyming and nonrhyming false-positive errors for the normal readers. The older disabled readers' phonetic effect was comparable to that of the younger normal readers, suggesting a developmental lag in their use of phonetic coding in memory. Surprisingly, the normal readers' phonetic effect declined with age in the recognition task, but they maintained a significant advantage across age in the auditory WISC-R digit span recall test, and a test of phonological nonword decoding. The normals' decline with age in rhyming confusion may be due to an increase in the precision of their phonetic codes.
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