Refine
Year of publication
Document Type
- Article (17)
- Monograph/Edited Volume (1)
- Part of Periodical (1)
- Postprint (1)
Is part of the Bibliography
- yes (20)
Keywords
- gamma rays: general (2)
- Australia (1)
- Broad-spectrum antibiotic therapy (1)
- Familiengeschichte (1)
- Festschrift (1)
- Frühe Neuzeit (1)
- Genealogie (1)
- ISM (1)
- ISM: clouds (1)
- ISM: supernova remnants (1)
Institute
- Institut für Biochemie und Biologie (5)
- Institut für Physik und Astronomie (4)
- Institut für Mathematik (3)
- Department Psychologie (2)
- Department Linguistik (1)
- Institut für Ernährungswissenschaft (1)
- Institut für Geowissenschaften (1)
- Institut für Jüdische Studien und Religionswissenschaft (1)
- Institut für Umweltwissenschaften und Geographie (1)
- Mathematisch-Naturwissenschaftliche Fakultät (1)
Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice
(2018)
BackgroundAntibiotic exposure alters the microbiota, which can impact the inflammatory immune responses. Critically ill patients frequently receive antibiotic treatment and are often subjected to mechanical ventilation, which may induce local and systemic inflammatory responses and development of ventilator-induced lung injury (VILI). The aim of this study was to investigate whether disruption of the microbiota by antibiotic therapy prior to mechanical ventilation affects pulmonary inflammatory responses and thereby the development of VILI.MethodsMice underwent 6-8weeks of enteral antibiotic combination treatment until absence of cultivable bacteria in fecal samples was confirmed. Control mice were housed equally throughout this period. VILI was induced 3 days after completing the antibiotic treatment protocol, by high tidal volume (HTV) ventilation (34ml/kg; positive end-expiratory pressure=2 cmH(2)O) for 4h. Differences in lung function, oxygenation index, pulmonary vascular leakage, macroscopic assessment of lung injury, and leukocyte and lymphocyte differentiation were assessed. Control groups of mice ventilated with low tidal volume and non-ventilated mice were analyzed accordingly.ResultsAntibiotic-induced microbiota depletion prior to HTV ventilation led to aggravation of VILI, as shown by increased pulmonary permeability, increased oxygenation index, decreased pulmonary compliance, enhanced macroscopic lung injury, and increased cytokine/chemokine levels in lung homogenates.ConclusionsDepletion of the microbiota by broad-spectrum antibiotics prior to HTV ventilation renders mice more susceptible to developing VILI, which could be clinically relevant for critically ill patients frequently receiving broad-spectrum antibiotics.
Young core-collapse supernovae with dense-wind progenitors may be able to accelerate cosmic-ray hadrons beyond the knee of the cosmic-ray spectrum, and this may result in measurable gamma-ray emission. We searched for gamma-ray emission from ten super- novae observed with the High Energy Stereoscopic System (H.E.S.S.) within a year of the supernova event. Nine supernovae were observed serendipitously in the H.E.S.S. data collected between December 2003 and December 2014, with exposure times ranging from 1.4 to 53 h. In addition we observed SN 2016adj as a target of opportunity in February 2016 for 13 h. No significant gamma-ray emission has been detected for any of the objects, and upper limits on the >1 TeV gamma-ray flux of the order of similar to 10(-13) cm(-)(2)s(-1) are established, corresponding to upper limits on the luminosities in the range similar to 2 x 10(39) to similar to 1 x 10(42) erg s(-1). These values are used to place model-dependent constraints on the mass-loss rates of the progenitor stars, implying upper limits between similar to 2 x 10(-5) and similar to 2 x 10(-3) M-circle dot yr(-1) under reasonable assumptions on the particle acceleration parameters.
The selaginella genome identifies genetic changes associated with the evolution of vascular plants
(2011)
Vascular plants appeared similar to 410 million years ago, then diverged into several lineages of which only two survive: the euphyllophytes (ferns and seed plants) and the lycophytes. We report here the genome sequence of the lycophyte Selaginella moellendorffii (Selaginella), the first nonseed vascular plant genome reported. By comparing gene content in evolutionarily diverse taxa, we found that the transition from a gametophyte- to a sporophyte-dominated life cycle required far fewer new genes than the transition from a nonseed vascular to a flowering plant, whereas secondary metabolic genes expanded extensively and in parallel in the lycophyte and angiosperm lineages. Selaginella differs in posttranscriptional gene regulation, including small RNA regulation of repetitive elements, an absence of the trans-acting small interfering RNA pathway, and extensive RNA editing of organellar genes.
role of subducted slabs
(2017)
The Jewish family has been the subject of much admiration and analysis, criticism and myth-making, not just but especially in modern times. As a field of inquiry, its place is at the intersection – or in the shadow – of the great topics in Jewish Studies and its contributing disciplines. Among them are the modernization and privatization of Judaism and Jewish life; integration and distinctiveness of Jews as individuals and as a group; gender roles and education. These and related questions have been the focus of modern Jewish family research, which took shape as a discipline in the 1910s.
This issue of PaRDeS traces the origins of academic Jewish family research and takes stock of its development over a century, with its ruptures that have added to the importance of familial roots and continuities. A special section retrieves the founder of the field, Arthur Czellitzer (1871–1943), his biography and work from oblivion and places him in the context of early 20th-century science and Jewish life.
The articles on current questions of Jewish family history reflect the topic’s potential for shedding new light on key questions in Jewish Studies past and present. Their thematic range – from 13th-century Yiddish Arthurian romances via family-based business practices in 19th-century Hungary and Germany, to concepts of Jewish parenthood in Imperial Russia – illustrates the broad interest in Jewish family research as a paradigm for early modern and modern Jewish Studies.
Of Trees and Birds
(2019)
Gisbert Fanselow’s work has been invaluable and inspiring to many researchers working on syntax, morphology, and information structure, both from a theoretical and from an experimental perspective. This volume comprises a collection of articles dedicated to Gisbert on the occasion of his 60th birthday, covering a range of topics from these areas and beyond. The contributions have in common that in a broad sense they have to do with language structures (and thus trees), and that in a more specific sense they have to do with birds. They thus cover two of Gisbert’s major interests in- and outside of the linguistic world (and perhaps even at the interface).
The hybrid regularization technique developed at the Institute of Mathematics of Potsdam University (IMP) is used to derive microphysical properties such as effective radius, surface-area concentration, and volume concentration, as well as the single-scattering albedo and a mean complex refractive index, from multiwavelength lidar measurements. We present the continuation of investigations of the IMP method. Theoretical studies of the degree of ill-posedness of the underlying model, simulation results with respect to the analysis of the retrieval error of microphysical particle properties from multiwavelength lidar data, and a comparison of results for different numbers of backscatter and extinction coefficients are presented. Our analysis shows that the backscatter operator has a smaller degree of ill- posedness than the operator for extinction. This fact underlines the importance of backscatter data. Moreover, the degree of ill-posedness increases with increasing particle absorption, i.e., depends on the imaginary part of the refractive index and does not depend significantly on the real part. Furthermore, an extensive simulation study was carried out for logarithmic-normal size distributions with different median radii, mode widths, and real and imaginary parts of refractive indices. The errors of the retrieved particle properties obtained from the inversion of three backscatter (355, 532, and 1064 nm) and two extinction (355 and 532 nm) coefficients were compared with the uncertainties for the case of six backscatter (400. 710, 800 nm. additionally) and the same two extinction coefficients. For known complex refractive index and up to 20% normally distributed noise, we found that the retrieval errors for effective radius, surface-area concentration, and volume concentration stay below approximately 15% in both cases. Simulations were also made with unknown complex refractive index. In that case the integrated parameters stay below approximately 30%, and the imaginary part of the refractive index stays below 35% for input noise up to 10% in both cases. In general, the quality of the retrieved aerosol parameters depends strongly on the imaginary part owing to the degree of ill-posedness. It is shown that under certain constraints a minimum data set of three backscatter coefficients and two extinction coefficients is sufficient for a successful inversion. The IMP algorithm was finally tested for a measurement case. (C) 2005 Optical Society of America
Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight-blood pressure association is attributable to genetic effects, and not to intrauterine programming.
Low thermal conductivity boulder with high porosity identified on C-type asteroid (162173) Ryugu
(2019)
C-type asteroids are among the most pristine objects in the Solar System, but little is known about their interior structure and surface properties. Telescopic thermal infrared observations have so far been interpreted in terms of a regolith-covered surface with low thermal conductivity and particle sizes in the centimetre range. This includes observations of C-type asteroid (162173) Ryugu1,2,3. However, on arrival of the Hayabusa2 spacecraft at Ryugu, a regolith cover of sand- to pebble-sized particles was found to be absent4,5 (R.J. et al., manuscript in preparation). Rather, the surface is largely covered by cobbles and boulders, seemingly incompatible with the remote-sensing infrared observations. Here we report on in situ thermal infrared observations of a boulder on the C-type asteroid Ryugu. We found that the boulder’s thermal inertia was much lower than anticipated based on laboratory measurements of meteorites, and that a surface covered by such low-conductivity boulders would be consistent with remote-sensing observations. Our results furthermore indicate high boulder porosities as well as a low tensile strength in the few hundred kilopascal range. The predicted low tensile strength confirms the suspected observational bias6 in our meteorite collections, as such asteroidal material would be too frail to survive atmospheric entry7