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This study investigated whether Mandarin speakers interpret prosodic information as focus markers in a sentence-picture verification task. Previous production studies have shown that both Mandarin-speaking adults and Mandarin-speaking children mark focus by prosodic information (Ouyang and Kaiser in Lang Cogn Neurosc 30(1-2):57-72, 2014; Yang and Chen in Prosodic focus marking in Chinese four-and eight-year-olds, 2014). However, while prosodic focus marking did not seem to affect sentence comprehension in adults Mandarin-speaking children showed enhanced sentence comprehension when the sentence focus was marked by prosodic information in a previous study (Chen in Appl Psycholinguist 19(4):553-582, 1998). The present study revisited this difference between Mandarin speaking adults and children by applying a newly designed task that tested the use of prosodic information to identify the sentence focus. No evidence was obtained that Mandarin-speaking children (as young as 3years of age) adhered more strongly to prosodic information than adults but that word order was the strongest cue for their focus interpretation. Our findings support the view that children attune to the specific means of information structure marking in their ambient language at an early age.
A catalog of genetic loci associated with kidney function from analyses of a million individuals
(2019)
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.