Refine
Has Fulltext
- no (1)
Year of publication
- 2019 (1)
Document Type
- Article (1)
Language
- English (1)
Is part of the Bibliography
- yes (1)
Keywords
- MMF (1)
- TGF-beta (1)
- clusterin (1)
- immune-inflammatory biomarkers (1)
- repeated measures design (1)
- reproducibility (1)
- suPAR (1)
Institute
Aim: Assessment of the feasibility and reliability of immune-inflammatory biomarker measurements. Methods: The following biomarkers were assessed in 207 predominantly healthy participants at baseline and after 4 months: MMF, TGF-beta, suPAR and clusterin. Results: Intraclass correlation coefficients (95% CIs) ranged from good for TGF-beta (0.75 [95% CI: 0.33-0.90]) to excellent for MMF (0.81 [95% CI: 0.64-0.90]), clusterin (0.83 [95% CI: 0.78-0.87]) and suPAR (0.91 [95% CI: 0.88-0.93]). Measurement of TGF-beta was challenged by the large number of values below the detection limit. Conclusion: Single measurements of suPAR, clusterin and MMF could serve as feasible and reliable biomarkers of immune-inflammatory pathways in biomedical research.