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Background: Wearable multi-modal time-series classification applications outperform their best uni-modal counterparts and hold great promise. A modality that directly measures electrical correlates from the brain is electroencephalography. Due to varying noise sources, different key brain regions, key frequency bands, and signal characteristics like non-stationarity, techniques for data pre-processing and classification algorithms are task-dependent.
Method: Here, a systematic literature review on mental state classification for wearable electroencephalog-raphy is presented. Four search terms in different combinations were used for an in-title search. The search was executed on the 29th of June 2022, across Google Scholar, PubMed, IEEEXplore, and ScienceDirect. 76 most relevant publications were set into context as the current state-of-the-art in mental state time-series classification.
Results: Pre-processing techniques, features, and time-series classification models were analyzed. Across publications, a window length of one second was mainly chosen for classification and spectral features were utilized the most. The achieved performance per time-series classification model is analyzed, finding linear discriminant analysis, decision trees, and k-nearest neighbors models outperform support-vector machines by a factor of up to 1.5. A historical analysis depicts future trends while under-reported aspects relevant to practical applications are discussed.
Conclusions: Five main conclusions are given, covering utilization of available area for electrode placement on the head, most often or scarcely utilized features and time-series classification model architectures, baseline reporting practices, as well as explainability and interpretability of Deep Learning. The importance of a 'test battery' assessing the influence of data pre-processing and multi-modality on time-series classification performance is emphasized.
Background
Many high-income countries are grappling with severe labour shortages in the healthcare sector. Refugees and recent migrants present a potential pool for staff recruitment due to their higher unemployment rates, younger age, and lower average educational attainment compared to the host society's labour force. Despite this, refugees and recent migrants, often possessing limited language skills in the destination country, are frequently excluded from traditional recruitment campaigns conducted solely in the host country’s language. Even those with intermediate language skills may feel excluded, as destination-country language advertisements are perceived as targeting only native speakers. This study experimentally assesses the effectiveness of a recruitment campaign for nursing positions in a German care facility, specifically targeting Arabic and Ukrainian speakers through Facebook advertisements.
Methods
We employ an experimental design (AB test) approximating a randomized controlled trial, utilizing Facebook as the delivery platform. We compare job advertisements for nursing positions in the native languages of Arabic and Ukrainian speakers (treatment) with the same advertisements displayed in German (control) for the same target group in the context of a real recruitment campaign for nursing jobs in Berlin, Germany. Our evaluation includes comparing link click rates, visits to the recruitment website, initiated applications, and completed applications, along with the unit cost of these indicators. We assess statistical significance in group differences using the Chi-squared test.
Results
We find that recruitment efforts in the origin language were 5.6 times (Arabic speakers) and 1.9 times (Ukrainian speakers) more effective in initiating nursing job applications compared to the standard model of German-only advertisements among recent migrants and refugees. Overall, targeting refugees and recent migrants was 2.4 (Ukrainians) and 10.8 (Arabic) times cheaper than targeting the reference group of German speakers indicating higher interest among these groups.
Conclusions
The results underscore the substantial benefits for employers in utilizing targeted recruitment via social media aimed at foreign-language communities within the country. This strategy, which is low-cost and low effort compared to recruiting abroad or investing in digitalization, has the potential for broad applicability in numerous high-income countries with sizable migrant communities. Increased employment rates among underemployed refugee and migrant communities, in turn, contribute to reducing poverty, social exclusion, public expenditure, and foster greater acceptance of newcomers within the receiving society.
Linguistic structure modulates attention in reading: evidence from negative concord in Italian
(2023)
Rossetto, Alessia ; Toraldo, Alessio ; Laratta, Stefania ; Tonin, Paolo ; Poletto, Cecilia ; Bencini, Giulia ; Semenza, Carlo
We report the reading performance of an Italian speaker with egocentric Neglect Dyslexia on sentences with Negative Concord structures, which contain a linguistic cue to the presence of a preceding negative marker and compare it to sentences with no such cue. As predicted, the frequency of reading the whole sentence, including the initial negative marker non, was higher in Negative Concord structures than in sentences which also started with non, but crucially, lacked the medially positioned linguistic cue to the presence of non.
These data support the claim that the presence of linguistic cues to sentence structure modulates attention during reading in Neglect Dyslexia.
Negra, Yassine ; Sammoud, Senda ; Uthoff, Aaron ; Moran, Jason ; Ramirez-Campillo, Rodrigo ; Chaabene, Helmi
This study explored the effects of an 8-week repeated backward running training (RBRT) programme on measures of physical fitness in youth male soccer players. Youth male soccer players were randomly allocated into a RBRT group (n = 20; 13.95 +/- 0.22y) or a control group (CG; n = 16; 14.86 +/- 0.29y). The CG continued normal soccer training, while the RBRT group replaced some soccer drills with RBRT twice per week. Within-group analysis revealed that RBRT improved all performance variables ( increment -9.99% to 14.50%; effect size [ES] = -1.79 to 1.29; p <= 0.001). Meanwhile, trivial-to-moderate detrimental effects on sprinting and change of direction (CoD) speed ( increment 1.55% to 10.40%; p <= 0.05) were noted in the CG. The number of individuals improving performance above the smallest worthwhile change ranged from 65-100% across all performance variables in the RBRT group, whereas<50% in the CG reached that threshold. The between-group analysis indicated that the RBRT group improved performance on all performance tasks more than the CG (ES = -2.23 to 1.10; p <= 0.05). These findings demonstrate that substituting part of a standard soccer training regimen with RBRT can enhance youth soccer players' sprinting, CoD, jumping, and RSA performance.
Nendel, Claas ; Reckling, Moritz ; Debaeke, Philippe ; Schulz, Susanne ; Berg-Mohnicke, Michael ; Constantin, Julie ; Fronzek, Stefan ; Hoffmann, Munir ; Jakšić, Snežana ; Kersebaum, Kurt-Christian ; Klimek-Kopyra, Agnieszka ; Raynal, Hélène ; Schoving, Céline ; Stella, Tommaso ; Battisti, Rafael
The European Union is highly dependent on soybean imports from overseas to meet its protein demands. Individual Member States have been quick to declare self-sufficiency targets for plant-based proteins, but detailed strategies are still lacking. Rising global temperatures have painted an image of a bright future for soybean production in Europe, but emerging climatic risks such as drought have so far not been included in any of those outlooks.
Here, we present simulations of future soybean production and the most prominent risk factors across Europe using an ensemble of climate and soybean growth models. Projections suggest a substantial increase in potential soybean production area and productivity in Central Europe, while southern European production would become increasingly dependent on supplementary irrigation. Average productivity would rise by 8.3% (RCP 4.5) to 8.7% (RCP 8.5) as a result of improved growing conditions (plant physiology benefiting from rising temperature and CO2 levels) and farmers adapting to them by using cultivars with longer phenological cycles. Suitable production area would rise by 31.4% (RCP 4.5) to 37.7% (RCP 8.5) by the mid-century, contributing considerably more than productivity increase to the production potential for closing the protein gap in Europe.
While wet conditions at harvest and incidental cold spells are the current key challenges for extending soybean production, the models and climate data analysis anticipate that drought and heat will become the dominant limitations in the future. Breeding for heat-tolerant and water-efficient genotypes is needed to further improve soybean adaptation to changing climatic conditions.
Neuromuscular control during stair descent and artificial tibial translation after acute ACL rupture
(2022)
Background: Anterior cruciate ligament (ACL) rupture has direct effect on passive and active knee stability and, specifically, stretch-reflex excitability. Purpose/Hypothesis: The purpose of this study was to investigate neuromuscular activity in patients with an acute ACL deficit (ACL-D group) compared with a matched control group with an intact ACL (ACL-I group) during stair descent and artificially induced anterior tibial translation. It was hypothesized that neuromuscular control would be impaired in the ACL-D group. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Surface electromyographic (EMG) activity of the vastus medialis (VM), vastus lateralis (VL), biceps femoris (BF), and semitendinosus (ST) muscles was recorded bilaterally in 15 patients with ACL-D (mean, 13.8 days [range, 7-21 days] since injury) and 15 controls with ACL-I during stair descent and artificially induced anterior tibial translation. The movements of stair descent were divided into preactivity, weight acceptance, and push-off phases. Reflex activity during anterior tibial translation was split into preactivity and short, medium, and late latency responses. Walking on a treadmill was used for submaximal EMG normalization. Kruskal-Wallis test and post hoc analyses with Dunn-Bonferroni correction were used to compare normalized root mean square values for each muscle, limb, movement, and reflex phase between the ACL-D and ACL-I groups. Results: During the preactivity phase of stair descent, the hamstrings of the involved leg of the ACL-D group showed 33% to 51% less activity compared with the matched leg and contralateral leg of the ACL-I group (P <.05). During the weight acceptance and push-off phases, the VL revealed a significant reduction (approximately 40%) in the involved leg of the ACL-D group compared with the ACL-I group. At short latency, the BF and ST of the involved leg of the ACL-D group showed a significant increase in EMG activity compared with the uninvolved leg of the ACL-I group, by a factor of 2.2 to 4.6. Conclusion: In the acute phase after an ACL rupture, neuromuscular alterations were found mainly in the hamstrings of both limbs during stair descent and reflex activity. The potential role of prehabilitation needs to be further studied.
Woody plants provide natural archives of climatic variation which can be investigated by applying dendroclimatological methods. Such studies are limited in Southern Africa but have great potential of improving our understanding of past climates and plant functional adaptations in the region. This study therefore investigated the responsiveness of Dichrostachys cinerea to seasonal variations in temperature and rainfall at two sites in central Namibia, Waterberg and Kuzikus. Dichrostachys cinerea is one of the encroacher species thriving well in Namibia. A moving correlation and response function analysis were used to test its responsiveness to seasonal climatic variations over time. Dichrostachys cinerea growth rings showed relationships to late summer warming, lasting up to half of the rainy season. The results also revealed that past temperatures had been fluctuating and their influence on growth rings had been intensifying over the years, but to varying extents between the two sites. Temperature was a more important determinant of ring growth at the drier site (Kuzikus), while rainfall was more important at the wetter site (Waterberg). Growth ring responsiveness to rainfall was not immediate but showed a rather lagged pattern. We conclude that D. cinerea differentially responds to variations in rainfall and temperature across short climatic gradients. This study showed that the species, due to its somewhat wide ecological amplitude, has great potential for dendroclimatological studies in tropical regions.
Schelling's classical segregation model gives a coherent explanation for the wide-spread phenomenon of residential segregation. We introduce an agent-based saturated open-city variant, the Flip Schelling Process (FSP), in which agents, placed on a graph, have one out of two types and, based on the predominant type in their neighborhood, decide whether to change their types; similar to a new agent arriving as soon as another agent leaves the vertex. We investigate the probability that an edge {u,v} is monochrome, i.e., that both vertices u and v have the same type in the FSP, and we provide a general framework for analyzing the influence of the underlying graph topology on residential segregation. In particular, for two adjacent vertices, we show that a highly decisive common neighborhood, i.e., a common neighborhood where the absolute value of the difference between the number of vertices with different types is high, supports segregation and, moreover, that large common neighborhoods are more decisive. As an application, we study the expected behavior of the FSP on two common random graph models with and without geometry: (1) For random geometric graphs, we show that the existence of an edge {u,v} makes a highly decisive common neighborhood for u and v more likely. Based on this, we prove the existence of a constant c>0 such that the expected fraction of monochrome edges after the FSP is at least 1/2+c. (2) For Erdős–Rényi graphs we show that large common neighborhoods are unlikely and that the expected fraction of monochrome edges after the FSP is at most 1/2+o(1). Our results indicate that the cluster structure of the underlying graph has a significant impact on the obtained segregation strength.
Purpose
With shorter product cycles and a growing number of knowledge-intensive business processes, time consumption is a highly relevant target factor in measuring the performance of contemporary business processes. This research aims to extend prior research on the effects of knowledge transfer velocity at the individual level by considering the effect of complexity, stickiness, competencies, and further demographic factors on knowledge-intensive business processes at the conversion-specific levels.
Design/methodology/approach
We empirically assess the impact of situation-dependent knowledge transfer velocities on time consumption in teams and individuals. Further, we issue the demographic effect on this relationship. We study a sample of 178 experiments of project teams and individuals applying ordinary least squares (OLS) for regression analysis-based modeling.
Findings
The authors find that time consumed at knowledge transfers is negatively associated with the complexity of tasks. Moreover, competence among team members has a complementary effect on this relationship and stickiness retards knowledge transfers. Thus, while demographic factors urgently need to be considered for effective and speedy knowledge transfers, these influencing factors should be addressed on a conversion-specific basis so that some tasks are realized in teams best while others are not. Guidelines and interventions are derived to identify best task realization variants, so that process performance is improved by a new kind of process improvement method.
Research limitations/implications
This study establishes empirically the importance of conversion-specific influence factors and demographic factors as drivers of high knowledge transfer velocities in teams and among individuals. The contribution connects the field of knowledge management to important streams in the wider business literature: process improvement, management of knowledge resources, design of information systems, etc. Whereas the model is highly bound to the experiment tasks, it has high explanatory power and high generalizability to other contexts.
Practical implications
Team managers should take care to allow the optimal knowledge transfer situation within the team. This is particularly important when knowledge sharing is central, e.g. in product development and consulting processes. If this is not possible, interventions should be applied to the individual knowledge transfer situation to improve knowledge transfers among team members.
Social implications
Faster and more effective knowledge transfers improve the performance of both commercial and non-commercial organizations. As nowadays, the individual is faced with time pressure to finalize tasks, the deliberated increase of knowledge transfer velocity is a core capability to realize this goal. Quantitative knowledge transfer models result in more reliable predictions about the duration of knowledge transfers. These allow the target-oriented modification of knowledge transfer situations so that processes speed up, private firms are more competitive and public services are faster to citizens.
Originality/value
Time consumption is an increasingly relevant factor in contemporary business but so far not been explored in experiments at all. This study extends current knowledge by considering quantitative effects on knowledge velocity and improved knowledge transfers.
Low-energy (5-20 eV) electron-induced single and double strand breaks in well-defined DNA sequences
(2022)
Ionizing radiation is used in cancer radiation therapy to effectively damage the DNA of tumors. The main damage is due to generation of highly reactive secondary species such as low-energy electrons (LEEs). The accurate quantification of DNA radiation damage of well-defined DNA target sequences in terms of absolute cross sections for LEE-induced DNA strand breaks is possible by the DNA origami technique; however, to date, it is possible only for DNA single strands. In the present work DNA double strand breaks in the DNA sequence 5 '-d(CAC)4/5 ' d(GTG)4 are compared with DNA single strand breaks in the oligonucleotides 5 '-d(CAC)4 and 5 '-d(GTG)4 upon irradiation with LEEs in the energy range from 5 to 20 eV. A maximum of strand break cross section was found around 7 and 10 eV independent of the DNA sequence, indicating that dissociative electron attachment is the underlying mechanism of strand breakage and confirming previous studies using plasmid DNA.
Existing curricula for entrepreneurship education do not necessarily represent the best way of teaching. How could entrepreneurship curricula be improved? To answer this question, we aim to identify and rank desirable teaching objectives, teaching contents, teaching methods, and assessment methods for higher entrepreneurship education. To this end, we employ an international real-time Delphi study with an expert panel consisting of entrepreneurship education instructors and researchers. The study reveals 17 favorable objectives, 17 items of content, 25 teaching methods, and 15 assessment methods, which are ranked according to their desirability and the group consensus. We contribute to entrepreneurship curriculum research by adding a normative perspective.
‘Modern talking’
(2024)
Despite growing interest, we lack a clear understanding of how the arguably ambiguous phenomenon of agile is perceived in government practice. This study aims to alleviate this puzzle by investigating how managers and employees in German public sector organisations make sense of agile as a spreading management fashion in the form of narratives. This is important because narratives function as innovation carriers that ultimately influence the manifestations of the concept in organisations. Based on a multi-case study of 31 interviews and 24 responses to a qualitative online survey conducted in 2021 and 2022, we provide insights into what public sector managers, employees and consultants understand (and, more importantly, do not understand) as agile and how they weave it into their existing reality of bureaucratic organisations. We uncover three meta-narratives of agile government, which we label ‘renew’, ‘complement’ and ‘integrate’. In particular, the meta-narratives differ in their positioning of how agile interacts with the characteristics of bureaucratic organisations. Importantly, we also show that agile as a management fad serves as a projection surface for what actors want from a modern and digital organisation. Thus, the vocabulary of agile government within the narratives is inherently linked to other diffusing phenomena such as new work or digitalisation.
Durand, Gael ; van den Broeke, Michiel R. ; Le Cozannet, Goneri ; Edwards, Tamsin L. ; Holland, Paul R. ; Jourdain, Nicolas C. ; Marzeion, Ben ; Mottram, Ruth ; Nicholls, Robert J. ; Pattyn, Frank ; Paul, Frank ; Slangen, Aimee B. A. ; Winkelmann, Ricarda ; Burgard, Clara ; van Calcar, Caroline J. ; Barre, Jean-Baptiste ; Bataille, Amelie ; Chapuis, Anne
Coastal areas are highly diverse, ecologically rich, regions of key socio-economic activity, and are particularly sensitive to sea-level change. Over most of the 20th century, global mean sea level has risen mainly due to warming and subsequent expansion of the upper ocean layers as well as the melting of glaciers and ice caps. Over the last three decades, increased mass loss of the Greenland and Antarctic ice sheets has also started to contribute significantly to contemporary sea-level rise. The future mass loss of the two ice sheets, which combined represent a sea-level rise potential of similar to 65 m, constitutes the main source of uncertainty in long-term (centennial to millennial) sea-level rise projections. Improved knowledge of the magnitude and rate of future sea-level change is therefore of utmost importance. Moreover, sea level does not change uniformly across the globe and can differ greatly at both regional and local scales. The most appropriate and feasible sea level mitigation and adaptation measures in coastal regions strongly depend on local land use and associated risk aversion. Here, we advocate that addressing the problem of future sea-level rise and its impacts requires (i) bringing together a transdisciplinary scientific community, from climate and cryospheric scientists to coastal impact specialists, and (ii) interacting closely and iteratively with users and local stakeholders to co-design and co-build coastal climate services, including addressing the high-end risks.
Kothari, Kritika ; Battisti, Rafael ; Boote, Kenneth J. ; Archontoulis, Sotirios ; Confalone, Adriana ; Constantin, Julie ; Cuadra, Santiago ; Debaeke, Philippe ; Faye, Babacar ; Grant, Brian ; Hoogenboom, Gerrit ; Jing, Qi ; van der Laan, Michael ; Macena da Silva, Fernando Antonio ; Marin, Fabio R. ; Nehbandani, Alireza ; Nendel, Claas ; Purcell, Larry C. ; Qian, Budong ; Ruane, Alex C. ; Schoving, Celine ; Silva, Evandro H. F. M. ; Smith, Ward ; Soltani, Afshin ; Srivastava, Amit ; Vieira, Nilson A. ; Slone, Stacey ; Salmeron, Montserrat
An accurate estimation of crop yield under climate change scenarios is essential to quantify our ability to feed a growing population and develop agronomic adaptations to meet future food demand. A coordinated evaluation of yield simulations from process-based eco-physiological models for climate change impact assessment is still missing for soybean, the most widely grown grain legume and the main source of protein in our food chain. In this first soybean multi-model study, we used ten prominent models capable of simulating soybean yield under varying temperature and atmospheric CO2 concentration [CO2] to quantify the uncertainty in soybean yield simulations in response to these factors. Models were first parametrized with high quality measured data from five contrasting environments. We found considerable variability among models in simulated yield responses to increasing temperature and [CO2]. For example, under a + 3 degrees C temperature rise in our coolest location in Argentina, some models simulated that yield would reduce as much as 24%, while others simulated yield increases up to 29%. In our warmest location in Brazil, the models simulated a yield reduction ranging from a 38% decrease under + 3 degrees C temperature rise to no effect on yield. Similarly, when increasing [CO2] from 360 to 540 ppm, the models simulated a yield increase that ranged from 6% to 31%. Model calibration did not reduce variability across models but had an unexpected effect on modifying yield responses to temperature for some of the models. The high uncertainty in model responses indicates the limited applicability of individual models for climate change food projections. However, the ensemble mean of simulations across models was an effective tool to reduce the high uncertainty in soybean yield simulations associated with individual models and their parametrization. Ensemble mean yield responses to temperature and [CO2] were similar to those reported from the literature. Our study is the first demonstration of the benefits achieved from using an ensemble of grain legume models for climate change food projections, and highlights that further soybean model development with experiments under elevated [CO2] and temperature is needed to reduce the uncertainty from the individual models.
Romero Barbosa, Luís ; Coelho, Victor Hugo R. ; Scheiffele, Lena ; Baroni, Gabriele ; Ramos Filho, Geraldo M. ; Montenegro, Suzana M. G. L. ; Das Neves Almeida, Cristiano ; Oswald, Sascha
Although cosmic-ray neutron sensing (CRNS) is probably the most promising noninvasive proximal soil moisture measurement technique at the field scale, its application for hydrological simulations remains underexplored in the literature so far. This study assessed the use of CRNS to inversely calibrate soil hydraulic parameters at the intermediate field scale to simulate the groundwater recharge rates at a daily timescale. The study was conducted for two contrasting hydrological years at the Guaraira experimental basin, Brazil, a 5.84-km(2), a tropical wet and rather flat landscape covered by secondary Atlantic forest. As a consequence of the low altitude and proximity to the equator low neutron count rates could be expected, reducing the precision of CRNS while constituting unexplored and challenging conditions for CRNS applications. Inverse calibration for groundwater recharge rates was used based on CRNS or point-scale soil moisture data. The CRNS-derived retention curve and saturated hydraulic conductivity were consistent with the literature and locally performed slug tests. Simulated groundwater recharge rates ranged from 60 to 470 mm yr(-1), corresponding to 5 and 29% of rainfall, and correlated well with estimates based on water table fluctuations. In contrast, the estimated results based on inversive point-scale datasets were not in alignment with measured water table fluctuations. The better performance of CRNS-based estimations of field-scale hydrological variables, especially groundwater recharge, demonstrated its clear advantages over traditional invasive point-scale techniques. Finally, the study proved the ability of CRNS as practicable in low altitude, tropical wet areas, thus encouraging its adoption for water resources monitoring and management.
This article analyses incremental institutional change and subsequent organizational and performance outcomes of the digital transformation from a comparative perspective. Through 31 expert interviews, the authors compare two digitalized public services in Germany. Two digitalization approaches are identified. The voluntary, decentralized bottom-up approach involves layering of new rules, limited organizational restructuring, and performance deficits. Conversely, the compulsory, top-down approach with centralized control facilitates displacement of existing rules and far-reaching organizational change; in this study, it is also associated with improved performance.
Kretzschmar, Mirjam E. ; Ashby, Ben ; Fearon, Elizabeth ; Overton, Christopher E. ; Panovska-Griffiths, Jasmina ; Pellis, Lorenzo ; Quaife, Matthew ; Rozhnova, Ganna ; Scarabel, Francesca ; Stage, Helena B. ; Swallow, Ben ; Thompson, Robin N. ; Tildesley, Michael J. ; Villela, Daniel Campos
Mathematical modelling and statistical inference provide a framework to evaluate different non-pharmaceutical and pharmaceutical interventions for the control of epidemics that has been widely used during the COVID-19 pandemic. In this paper, lessons learned from this and previous epidemics are used to highlight the challenges for future pandemic control. We consider the availability and use of data, as well as the need for correct parameterisation and calibration for different model frameworks. We discuss challenges that arise in describing and distinguishing between different interventions, within different modelling structures, and allowing both within and between host dynamics. We also highlight challenges in modelling the health economic and political aspects of interventions. Given the diversity of these challenges, a broad variety of interdisciplinary expertise is needed to address them, combining mathematical knowledge with biological and social insights, and including health economics and communication skills. Addressing these challenges for the future requires strong cross disciplinary collaboration together with close communication between scientists and policy makers.
Rajewar, S. K. ; Mohana Lakshmi, Ch. ; Mohanty, Aditya ; Pandey, Dwijendra N. ; Pandey, Anshuman ; Chaurasia, Anurag ; Pandey, Ananya ; Rajeswar Rao, V. ; Naidu, M. S. ; Kumar, Amit ; Mondal, Saroj K. ; Yadav, Rajeev K. ; Catherine, J. K. ; Giri, R. K. ; Gahalaut, Vineet Kumar
Geodetic studies of crustal deformation using Global Navigation Satellite System (GNSS, earlier commonly referred to as Global Positioning System, GPS) measurements at CSIR-NGRI started in 1995 with the installation of a permanent GNSS station at CSIR-NGRI Hyderabad which later became an International GNSS Service (IGS) site. The CSIR-NGRI started expanding its GNSS networks after 2003 with more focussed studies through installation in the NE India, Himalayan arc, Andaman subduction zone, stable and failed rift regions of India plate. In each instance, these measurements helped in unravelling the geodynamics of the region and seismic hazard assessment, e.g., the discovery of a plate boundary fault in the Indo-Burmese wedge, rate and mode of strain accumulation and its spatial variation in the Garhwal-Kumaun and Kashmir region of the Himalayan arc, the influence of non-tectonic deformation on tectonic deformation in the Himalayan arc, nature of crustal deformation through earthquake cycle in the Andaman Sumatra subduction zone, and localised deformation in the intraplate region and across the paleo rift regions. Besides these, GNSS measurements initiated in the Antarctica region have helped in understanding the plate motion and influence of seasonal variations on deformation. Another important by-product of the GNSS observations is the capabilities of these observations in understanding the ionospheric variations due to earthquake processes and also due to solar eclipse. We summarize these outcomes in this article.
Entrepreneurship education research has a strong “output” focus on impact studies but pays much less attention to the “inside” or process perspective of the way entrepreneurship education occurs. In particular, the scattered previous entrepreneurship curriculum research has not managed to provide a current and comprehensive overview of the curricular elements that constitute entrepreneurship education. To overcome this shortcoming, we aim to identify the teaching objectives, teaching contents, teaching methods, and assessment methods discussed in entrepreneurship curriculum research. To this end, we conducted a systematic literature review on the four entrepreneurship curriculum dimensions and collected all mentioned curriculum items. We used a two-stage coding procedure to find the genuinely entrepreneurship-specific items. Among numerous items (also from business management and other subjects), we found 26 objectives, 34 contents, 11 teaching methods, and 7 assessment methods that were entrepreneurship-specific. Most of these items were addressed by only a few scholarly papers.
The dark side of metaverse: a multi-perspective of deviant behaviors from PLS-SEM and fsQCA findings
(2024)
The metaverse has created a huge buzz of interest because such a phenomenon is emerging. The behavioral aspect of the metaverse includes user engagement and deviant behaviors in the metaverse. Such technology has brought various dangers to individuals and society. There are growing cases reported of sexual abuse, racism, harassment, hate speech, and bullying because of online disinhibition make us feel more relaxed. This study responded to the literature call by investigating the effect of technical and social features through mediating roles of security and privacy on deviant behaviors in the metaverse. The data collected from virtual network users reached 1121 respondents. Partial Least Squares based structural equation modeling (PLS-SEM) and fuzzy set Qualitative Comparative Analysis (fsQCA) were used. PLS-SEM results revealed that social features such as user-to-user interaction, homophily, social ties, and social identity, and technical design such as immersive experience and invisibility significantly affect users’ deviant behavior in the metaverse. The fsQCA results provided insights into the multiple causal solutions and configurations. This study is exceptional because it provided decisive results by understanding the deviant behavior of users based on the symmetrical and asymmetrical approach to virtual networks.
Purpose
The purpose of this study was to investigate work-related adaptive performance from a longitudinal process perspective. This paper clustered specific behavioral patterns following the introduction of a change and related them to retentivity as an individual cognitive ability. In addition, this paper investigated whether the occurrence of adaptation errors varied depending on the type of change content.
Design/methodology/approach
Data from 35 participants collected in the simulated manufacturing environment of a Research and Application Center Industry 4.0 (RACI) were analyzed. The participants were required to learn and train a manufacturing process in the RACI and through an online training program. At a second measurement point in the RACI, specific manufacturing steps were subject to change and participants had to adapt their task execution. Adaptive performance was evaluated by counting the adaptation errors.
Findings
The participants showed one of the following behavioral patterns: (1) no adaptation errors, (2) few adaptation errors, (3) repeated adaptation errors regarding the same actions, or (4) many adaptation errors distributed over many different actions. The latter ones had a very low retentivity compared to the other groups. Most of the adaptation errors were made when new actions were added to the manufacturing process.
Originality/value
Our study adds empirical research on adaptive performance and its underlying processes. It contributes to a detailed understanding of different behaviors in change situations and derives implications for organizational change management.
Kroke, Anja ; Schmidt, Annemarie ; Amini, Anna M. ; Kalotai, Nicole ; Lehmann, Andreas ; Haardt, Julia ; Bauer, Jürgen M. ; Bischoff-Ferrari, Heike A. ; Boeing, Heiner ; Egert, Sarah ; Ellinger, Sabine ; Kühn, Tilman ; Louis, Sandrine ; Lorkowski, Stefan ; Nimptsch, Katharina ; Remer, Thomas ; Schulze, Matthias B. ; Siener, Roswitha ; Stangl, Gabriele ; Volkert, Dorothee ; Zittermann, Armin ; Buyken, Anette E. ; Watzl, Bernhard ; Schwingshackl, Lukas
Purpose: The present work aimed to delineate (i) a revised protocol according to recent methodological developments in evidence generation, to (ii) describe its interpretation, the assessment of the overall certainty of evidence and to (iii) outline an Evidence to Decision framework for deriving an evidence-based guideline on quantitative and qualitative aspects of dietary protein intake. Methods A methodological protocol to systematically investigate the association between dietary protein intake and several health outcomes and for deriving dietary protein intake recommendations for the primary prevention of various non-communicable diseases in the general adult population was developed. Results The developed methodological protocol relies on umbrella reviews including systematic reviews with or without meta-analyses. Systematic literature searches in three databases will be performed for each health-related outcome. The methodological quality of all selected systematic reviews will be evaluated using a modified version of AMSTAR 2, and the outcome-specific certainty of evidence for systematic reviews with or without meta-analysis will be assessed with NutriGrade. The general outline of the Evidence to Decision framework foresees that recommendations in the derived guideline will be given based on the overall certainty of evidence as well as on additional criteria such as sustainability. Conclusion The methodological protocol permits a systematic evaluation of published systematic reviews on dietary protein intake and its association with selected health-related outcomes. An Evidence to Decision framework will be the basis for the overall conclusions and the resulting recommendations for dietary protein intake.
Anders, Friedrich ; Khalatyan, Arman ; Queiroz, Anna B. A. ; Chiappini, Cristina ; Ardèvol, Judith ; Casamiquela, Laia ; Figueras, Francesca ; Jiménez-Arranz, Óscar ; Jordi, Carme ; Monguio, Maria ; Romero-Gómez, Merce ; Altamirano, Diego ; Antoja, Teresa ; Assaad, R. ; Cantat-Gaudin, Tristan ; Castro-Ginard, Alfred ; Enke, Harry ; Girardi, Léo ; Guiglion, Guillaume ; Khan, Saniya ; Luri, Xavier ; Miglio, Andrea ; Minchev, Ivan ; Ramos, Pau ; Santiago, Basillio Xavier ; Steinmetz, Matthias
We present a catalogue of 362 million stellar parameters, distances, and extinctions derived from Gaia's Early Data Release (EDR3) cross-matched with the photometric catalogues of Pan-STARRS1, SkyMapper, 2MASS, and All WISE. The higher precision of the Gaia EDR3 data, combined with the broad wavelength coverage of the additional photometric surveys and the new stellar-density priors of the StarHorse code, allows us to substantially improve the accuracy and precision over previous photo-astrometric stellar-parameter estimates. At magnitude G = 14 (17), our typical precisions amount to 3% (15%) in distance, 0.13 mag (0.15 mag) in V-band extinction, and 140 K (180 K) in effective temperature. Our results are validated by comparisons with open clusters, as well as with asteroseismic and spectroscopic measurements, indicating systematic errors smaller than the nominal uncertainties for the vast majority of objects. We also provide distance- and extinction-corrected colour-magnitude diagrams, extinction maps, and extensive stellar density maps that reveal detailed substructures in the Milky Way and beyond. The new density maps now probe a much greater volume, extending to regions beyond the Galactic bar and to Local Group galaxies, with a larger total number density. We publish our results through an ADQL query interface (gaia . aip . de) as well as via tables containing approximations of the full posterior distributions. Our multi-wavelength approach and the deep magnitude limit render our results useful also beyond the next Gaia release, DR3.
Pohanková, Eva ; Hlavinka, Petr ; Kersebaum, Kurt-Christian ; Rodríguez, Alfredo ; Balek, Jan ; Bednařík, Martin ; Dubrovský, Martin ; Gobin, Anne ; Hoogenboom, Gerrit ; Moriondo, Marco ; Nendel, Claas ; Olesen, Jørgen E. E. ; Rötter, Reimund Paul ; Ruiz-Ramos, Margarita ; Shelia, Vakhtang ; Stella, Tommaso ; Hoffmann, Munir Paul ; Takáč, Jozef ; Eitzinger, Josef ; Dibari, Camilla ; Ferrise, Roberto ; Bláhová, Monika ; Trnka, Miroslav
Crop rotation, fertilization and residue management affect the water balance and crop production and can lead to different sensitivities to climate change. To assess the impacts of climate change on crop rotations (CRs), the crop model ensemble (APSIM,AQUACROP, CROPSYST, DAISY, DSSAT, HERMES, MONICA) was used. The yields and water balance of two CRs with the same set of crops (winter wheat, silage maize, spring barley and winter rape) in a continuous transient run from 1961 to 2080 were simulated. CR1 was without cover crops and without manure application. Straw after the harvest was exported from the fields. CR2 included cover crops, manure application and crop residue retention left on field. Simulations were performed using two soil types (Chernozem, Cambisol) within three sites in the Czech Republic, which represent temperature and precipitation gradients for crops in Central Europe. For the description of future climatic conditions, seven climate scenarios were used. Six of them had increasing CO & nbsp;concentrations according RCP 8.5, one had no CO2 increase in the future. The output of an ensemble expected higher productivity by 0.82 t/ha/year and 2.04 t/ha/year for yields and aboveground biomass in the future (2051-2080). However, if the direct effect of a CO2 increase is not considered, the average yields for lowlands will be lower. Compared to CR1, CR2 showed higher average yields of 1.26 t/ha/year for current climatic conditions and 1.41 t/ha/year for future climatic conditions. For the majority of climate change scenarios, the crop model ensemble agrees on the projected yield increase in C3 crops in the future for CR2 but not for CR1. Higher agreement for future yield increases was found for Chernozem, while for Cambisol, lower yields under dry climate scenarios are expected. For silage maize, changes in simulated yields depend on locality. If the same hybrid will be used in the future, then yield reductions should be expected within lower altitudes. The results indicate the potential for higher biomass production from cover crops, but CR2 is associated with almost 120 mm higher evapotranspiration compared to that of CR1 over a 5-year cycle for lowland stations in the future, which in the case of the rainfed agriculture could affect the long-term soil water balance. This could affect groundwater replenishment, especially for locations with fine textured soils, although the findings of this study highlight the potential for the soil water-holding capacity to buffer against the adverse weather conditions.
Förstner, Bernd R. ; Tschorn, Mira ; Reinoso-Schiller, Nicolas ; Maričić, Lea Mascarell ; Röcher, Erik ; Kalman, Janos L. ; Stroth, Sanna ; Mayer, Annalina V. ; Schwarz, Kristina ; Kaiser, Anna ; Pfennig, Andrea ; Manook, André ; Ising, Marcus ; Heinig, Ingmar ; Pittig, Andre ; Heinz, Andreas ; Mathiak, Klaus ; Schulze, Thomas G. ; Schneider, Frank ; Kamp-Becker, Inge ; Meyer-Lindenberg, Andreas ; Padberg, Frank ; Banaschewski, Tobias ; Bauer, Michael ; Rupprecht, Rainer ; Wittchen, Hans-Ulrich ; Rapp, Michael A.
This study aimed to build on the relationship of well-established self-report and behavioral assessments to the latent constructs positive (PVS) and negative valence systems (NVS), cognitive systems (CS), and social processes (SP) of the Research Domain Criteria (RDoC) framework in a large transnosological population which cuts across DSM/ICD-10 disorder criteria categories. One thousand four hundred and thirty one participants (42.1% suffering from anxiety/fear-related, 18.2% from depressive, 7.9% from schizophrenia spectrum, 7.5% from bipolar, 3.4% from autism spectrum, 2.2% from other disorders, 18.4% healthy controls, and 0.2% with no diagnosis specified) recruited in studies within the German research network for mental disorders for the Phenotypic, Diagnostic and Clinical Domain Assessment Network Germany (PD-CAN) were examined with a Mini-RDoC-Assessment including behavioral and self-report measures. The respective data was analyzed with confirmatory factor analysis (CFA) to delineate the underlying latent RDoC-structure. A revised four-factor model reflecting the core domains positive and negative valence systems as well as cognitive systems and social processes showed a good fit across this sample and showed significantly better fit compared to a one factor solution. The connections between the domains PVS, NVS and SP could be substantiated, indicating a universal latent structure spanning across known nosological entities. This study is the first to give an impression on the latent structure and intercorrelations between four core Research Domain Criteria in a transnosological sample. We emphasize the possibility of using already existing and well validated self-report and behavioral measurements to capture aspects of the latent structure informed by the RDoC matrix.
Ruipérez-Valiente, José A. ; Staubitz, Thomas ; Jenner, Matt ; Halawa, Sherif ; Zhang, Jiayin ; Despujol, Ignacio ; Maldonado-Mahauad, Jorge ; Montoro, German ; Peffer, Melanie ; Rohloff, Tobias ; Lane, Jenny ; Turro, Carlos ; Li, Xitong ; Pérez-Sanagustín, Mar ; Reich, Justin
Massive Open Online Courses (MOOCs) remarkably attracted global media attention, but the spotlight has been concentrated on a handful of English-language providers. While Coursera, edX, Udacity, and FutureLearn received most of the attention and scrutiny, an entirely new ecosystem of local MOOC providers was growing in parallel. This ecosystem is harder to study than the major players: they are spread around the world, have less staff devoted to maintaining research data, and operate in multiple languages with university and corporate regional partners. To better understand how online learning opportunities are expanding through this regional MOOC ecosystem, we created a research partnership among 15 different MOOC providers from nine countries. We gathered data from over eight million learners in six thousand MOOCs, and we conducted a large-scale survey with more than 10 thousand participants. From our analysis, we argue that these regional providers may be better positioned to meet the goals of expanding access to higher education in their regions than the better-known global providers. To make this claim we highlight three trends: first, regional providers attract a larger local population with more inclusive demographic profiles; second, students predominantly choose their courses based on topical interest, and regional providers do a better job at catering to those needs; and third, many students feel more at ease learning from institutions they already know and have references from. Our work raises the importance of local education in the global MOOC ecosystem, while calling for additional research and conversations across the diversity of MOOC providers.
Keles, Engin ; Mallonn, Matthias ; Kitzmann, Daniel ; Poppenhäger, Katja ; Hoeijmakers, H. Jens ; Ilyin, Ilya ; Alexoudi, Xanthippi ; Carroll, Thorsten A. ; Alvarado-Gomez, Julian ; Ketzer, Laura ; Bonomo, Aldo S. ; Borsa, Francesco ; Gaudi, B. Scott ; Henning, Thomas ; Malavolta, Luca ; Molaverdikhani, Karan ; Nascimbeni, Valerio ; Patience, Jennifer ; Pino, Lorenzo ; Scandariato, Gaetano ; Schlawin, Everett ; Shkolnik, Evgenya ; Sicilia, Daniela ; Sozzetti, Alessandro ; Foster, Mary G. ; Veillet, Christian ; Wang, Ji ; Yan, Fei ; Strassmeier, Klaus G.
The study of exoplanets and especially their atmospheres can reveal key insights on their evolution by identifying specific atmospheric species. For such atmospheric investigations, high-resolution transmission spectroscopy has shown great success, especially for Jupiter-type planets. Towards the atmospheric characterization of smaller planets, the super-Earth exoplanet 55 Cnc e is one of the most promising terrestrial exoplanets studied to date. Here, we present a high-resolution spectroscopic transit observation of this planet, acquired with the PEPSI instrument at the Large Binocular Telescope. Assuming the presence of Earth-like crust species on the surface of 55 Cnc e, from which a possible silicate-vapor atmosphere could have originated, we search in its transmission spectrum for absorption of various atomic and ionized species such as Fe , Fe (+), Ca , Ca (+), Mg, and K , among others. Not finding absorption for any of the investigated species, we are able to set absorption limits with a median value of 1.9 x R-P. In conclusion, we do not find evidence of a widely extended silicate envelope on this super-Earth reaching several planetary radii.
Wang, Enli ; He, Di ; Wang, Jing ; Lilley, Julianne M. ; Christy, Brendan ; Hoffmann, Munir P. ; O'Leary, Garry ; Hatfield, Jerry L. ; Ledda, Luigi ; Deligios, Paola A. ; Grant, Brian ; Jing, Qi ; Nendel, Claas ; Kage, Henning ; Qian, Budong ; Rezaei, Ehsan Eyshi ; Smith, Ward ; Weymann, Wiebke ; Ewert, Frank
To better understand how climate change might influence global canola production, scientists from six countries have completed the first inter-comparison of eight crop models for simulating growth and seed yield of canola, based on experimental data from six sites across five countries. A sensitivity analysis was conducted with a combination of five levels of atmospheric CO2 concentrations, seven temperature changes, five precipitation changes, together with five nitrogen application rates. Our results were in several aspects different from those of previous model inter-comparison studies for wheat, maize, rice, and potato crops. A partial model calibration only on phenology led to very poor simulation of aboveground biomass and seed yield of canola, even from the ensemble median or mean. A full calibration with additional data of leaf area index, biomass, and yield from one treatment at each site reduced simulation error of seed yield from 43.8 to 18.0%, but the uncertainty in simulation results remained large. Such calibration (with data from one treatment) was not able to constrain model parameters to reduce simulation uncertainty across the wide range of environments. Using a multi-model ensemble mean or median reduced the uncertainty of yield simulations, but the simulation error remained much larger than observation errors, indicating no guarantee that the ensemble mean/median would predict the correct responses. Using multi-model ensemble median, canola yield was projected to decline with rising temperature (2.5-5.7% per degrees C), but to increase with increasing CO2 concentration (4.6-8.3% per 100-ppm), rainfall (2.1-6.1% per 10% increase), and nitrogen rates (1.3-6.0% per 10% increase) depending on locations. Due to the large uncertainty, these results need to be treated with caution. We further discuss the need to collect new data to improve modelling of several key physiological processes of canola for increased confidence in future climate impact assessments.
Kramer, Koen ; Bouriaud, Laura ; Feindt, Peter H. ; van Wassenaer, Lan ; Glanemann, Nicole ; Hanewinkel, Marc ; van der Heide, Martijn ; Hengeveld, Geerten M. ; Hoogstra, Marjanke ; Ingram, Verina ; Levermann, Anders ; Lindner, Marcus ; Mátyás, Csaba ; Mohren, Frits ; Muys, Bart ; Nabuurs, Gert-Jan ; Palahi, Marc ; Polman, Nico ; Reyer, Christopher P. O. ; Schulze, Ernst-Detlef ; Seidl, Rupert ; de Vries, Wim ; Werners, Saskia E. ; Winkel, Georg ; Yousefpour, Rasoul
Forests play a key role in a bio-based economy by providing renewable materials, mitigating climate change, and accommodating biodiversity. However, forests experience massive increases in stresses in their ecological and socioeconomic environments, threatening forest ecosystem services supply. Alleviating those stresses is hampered by conflicting and disconnected governance arrangements, competing interests and claims, and rapid changes in technology and social demands. Identifying which stresses threaten forest ecosystem services supply and which factors hamper their alleviation requires stakeholders' perceptions. Stakeholder-oriented stress tests for the supply of forest ecosystem services are therefore necessary but are not yet available. This perspective presents a roadmap to develop a stress test tailored to multiple stakeholders' needs and demands across spatial scales. We provide the Cascade and Resilience Rosetta, with accompanying performance- and resilience indicators, as tools to facilitate development of the stress test. The application of the stress test will facilitate the transition toward a bio-based economy in which healthy and diverse forests provide sustainable and resilient ecosystem services.
McHuron, Elizabeth A. ; Adamczak, Stephanie ; Arnould, John P. Y. ; Ashe, Erin ; Booth, Cormac ; Bowen, W. Don ; Christiansen, Fredrik ; Chudzinska, Magda ; Costa, Daniel P. ; Fahlman, Andreas ; Farmer, Nicholas A. ; Fortune, Sarah M. E. ; Gallagher, Cara A. ; Keen, Kelly A. ; Madsen, Peter T. ; McMahon, Clive R. ; Nabe-Nielsen, Jacob ; Noren, Dawn P. ; Noren, Shawn R. ; Pirotta, Enrico ; Rosen, David A. S. ; Speakman, Cassie N. ; Villegas-Amtmann, Stella ; Williams, Rob
Bioenergetic approaches are increasingly used to understand how marine mammal populations could be affected by a changing and disturbed aquatic environment. There remain considerable gaps in our knowledge of marine mammal bioenergetics, which hinder the application of bioenergetic studies to inform policy decisions. We conducted a priority-setting exercise to identify high-priority unanswered questions in marine mammal bioenergetics, with an emphasis on questions relevant to conservation and management. Electronic communication and a virtual workshop were used to solicit and collate potential research questions from the marine mammal bioenergetic community. From a final list of 39 questions, 11 were identified as 'key'questions because they received votes from at least 50% of survey participants. Key questions included those related to energy intake (prey landscapes, exposure to human activities) and expenditure (field metabolic rate, exposure to human activities, lactation, time-activity budgets), energy allocation priorities, metrics of body condition and relationships with survival and reproductive success and extrapolation of data from one species to another. Existing tools to address key questions include labelled water, animal-borne sensors, mark-resight data from long-term research programs, environmental DNA and unmanned vehicles. Further validation of existing approaches and development of new methodologies are needed to comprehensively address some key questions, particularly for cetaceans. The identification of these key questions can provide a guiding framework to set research priorities, which ultimately may yield more accurate information to inform policies and better conserve marine mammal populations.
Kowalczyk, Katarzyna A. ; Amann, Thorben ; Strefler, Jessica ; Vorrath, Maria-Elena ; Hartmann, Jens ; de Marco, Serena ; Renforth, Phil ; Foteinis, Spyros ; Kriegler, Elmar
To achieve the Paris climate target, deep emissions reductions have to be complemented with carbon dioxide removal (CDR). However, a portfolio of CDR options is necessary to reduce risks and potential negative side effects. Despite a large theoretical potential, ocean-based CDR such as ocean alkalinity enhancement (OAE) has been omitted in climate change mitigation scenarios so far. In this study, we provide a techno-economic assessment of large-scale OAE using hydrated lime ('ocean liming'). We address key uncertainties that determine the overall cost of ocean liming (OL) such as the CO2 uptake efficiency per unit of material, distribution strategies avoiding carbonate precipitation which would compromise efficiency, and technology availability (e.g., solar calciners). We find that at economic costs of 130–295 $/tCO2 net-removed, ocean liming could be a competitive CDR option which could make a significant contribution towards the Paris climate target. As the techno-economic assessment identified no showstoppers, we argue for more research on ecosystem impacts, governance, monitoring, reporting, and verification, and technology development and assessment to determine whether ocean liming and other OAE should be considered as part of a broader CDR portfolio.
Sporbert, Maria ; Jakubka, Desiree ; Bucher, Solveig Franziska ; Hensen, Isabell ; Freiberg, Martin ; Heubach, Katja ; König, Andreas ; Nordt, Birgit ; Plos, Carolin ; Blinova, Ilona ; Bonn, Aletta ; Knickmann, Barbara ; Koubek, Tomáš ; Linstädter, Anja ; Mašková, Tereza ; Primack, Richard B. ; Rosche, Christoph ; Shah, Manzoor A. ; Stevens, Albert-Dieter ; Tielbörger, Katja ; Träger, Sabrina ; Wirth, Christian ; Römermann, Christine
Phenology has emerged as key indicator of the biological impacts of climate change, yet the role of functional traits constraining variation in herbaceous species' phenology has received little attention. Botanical gardens are ideal places in which to investigate large numbers of species growing under common climate conditions. We ask whether interspecific variation in plant phenology is influenced by differences in functional traits. We recorded onset, end, duration and intensity of initial growth, leafing out, leaf senescence, flowering and fruiting for 212 species across five botanical gardens in Germany. We measured functional traits, including plant height, absolute and specific leaf area, leaf dry matter content, leaf carbon and nitrogen content and seed mass and accounted for species' relatedness. Closely related species showed greater similarities in timing of phenological events than expected by chance, but species' traits had a high degree of explanatory power, pointing to paramount importance of species' life-history strategies. Taller plants showed later timing of initial growth, and flowered, fruited and underwent leaf senescence later. Large-leaved species had shorter flowering and fruiting durations. Taller, large-leaved species differ in their phenology and are more competitive than smaller, small-leaved species. We assume climate warming will change plant communities' competitive hierarchies with consequences for biodiversity.
Hempel, Hannes ; Savenjie, Tom J. ; Stolterfoht, Martin ; Neu, Jens ; Failla, Michele ; Paingad, Vaisakh C. ; Kužel, Petr ; Heilweil, Edwin J. ; Spies, Jacob A. ; Schleuning, Markus ; Zhao, Jiashang ; Friedrich, Dennis ; Schwarzburg, Klaus ; Siebbeles, Laurens D. A. ; Dörflinger, Patrick ; Dyakonov, Vladimir ; Katoh, Ryuzi ; Hong, Min Ji ; Labram, John G. ; Monti, Maurizio ; Butler-Caddle, Edward ; Lloyd-Hughes, James ; Taheri, Mohammad M. ; Baxter, Jason B. ; Magnanelli, Timothy J. ; Luo, Simon ; Cardon, Joseph M. ; Ardo, Shane ; Unold, Thomas
Mobilities and lifetimes of photogenerated charge carriers are core properties of photovoltaic materials and can both be characterized by contactless terahertz or microwave measurements. Here, the expertise from fifteen laboratories is combined to quantitatively model the current-voltage characteristics of a solar cell from such measurements. To this end, the impact of measurement conditions, alternate interpretations, and experimental inter-laboratory variations are discussed using a (Cs,FA,MA)Pb(I,Br)(3) halide perovskite thin-film as a case study. At 1 sun equivalent excitation, neither transport nor recombination is significantly affected by exciton formation or trapping. Terahertz, microwave, and photoluminescence transients for the neat material yield consistent effective lifetimes implying a resistance-free JV-curve with a potential power conversion efficiency of 24.6 %. For grainsizes above approximate to 20 nm, intra-grain charge transport is characterized by terahertz sum mobilities of approximate to 32 cm(2) V-1 s(-1). Drift-diffusion simulations indicate that these intra-grain mobilities can slightly reduce the fill factor of perovskite solar cells to 0.82, in accordance with the best-realized devices in the literature. Beyond perovskites, this work can guide a highly predictive characterization of any emerging semiconductor for photovoltaic or photoelectrochemical energy conversion. A best practice for the interpretation of terahertz and microwave measurements on photovoltaic materials is presented.
Climatic and hydrological variability as a driver of the Lake Gościąż biota during the Younger Dryas
(2022)
Płóciennik, Mateusz ; Zawiska, Izabela ; Rzodkiewicz, Monika ; Noryśkiewicz, Agnieszka M. ; Słowiński, Michał ; Müller, Daniela ; Brauer, Achim ; Antczak-Orlewska, Olga ; Kramkowski, Mateusz ; Peyron, Odile ; Nevalainen, Liisa ; Luoto, Tomi P. ; Kotrys, Bartosz ; Seppä, Heikki ; Bidaurreta, Jon Camuera ; Rudna, Marta ; Mielczarek, Małgorzata ; Zawisza, Edyta ; Janowska, Ewa ; Błaszkiewicz, Mirosław
The Younger Dryas (YD) is a roughly 1,100-year cold period marking the end of the last glaciation. Climate modelling for northern Europe indicates high summer temperatures and strong continentality. In eastern Europe, the scale of temperature variation and its influence on ecosystems is weakly recognised. Here, we present a multi-proxy reconstruction of YD conditions from Lake Gos ' ciaz (central Poland). The decadal-resolution analysis of its annually varved sediments indicates an initial decrease in Chironomidae-inferred mean July air temperature followed by steady warming. The pollen-inferred winter-to-summer temperature amplitude and annual precip-itation is highest at the Allerod/YD transition and the early YD (ca. 12.7-12.4 ky cal BP) and YD/Holocene (11.7-11.4 ka cal BP) transition. Temperature and precipitation were the main reasons for lake level fluctuations as reflected in the planktonic/littoral Cladocera ratio. The lake's diatom-inferred total phosphorus decreased with increasing summer temperature from about mid YD. Windy conditions in the early YD until ~12.3 ka cal BP caused water mixing and a short-lived/temporary increase in nutrient availability for phytoplankton. The Chironomidae-inferred summer temperature and pollen inferred summer temperature, winter temperature and annual precipitation herein are one of only a few in eastern Europe conducted with such high resolution.
Huth, Sabrina ; Pang, Peter Tsun Ho ; Tews, Ingo ; Dietrich, Tim ; Le Fèvre, Arnaud ; Schwenk, Achim ; Trautmann, Wolfgang ; Agarwal, Kshitij ; Bulla, Mattia ; Coughlin, Michael W. ; Van den Broeck, Chris
Interpreting high-energy, astrophysical phenomena, such as supernova explosions or neutron-star collisions, requires a robust understanding of matter at supranuclear densities. However, our knowledge about dense matter explored in the cores of neutron stars remains limited. Fortunately, dense matter is not probed only in astrophysical observations, but also in terrestrial heavy-ion collision experiments. Here we use Bayesian inference to combine data from astrophysical multi-messenger observations of neutron stars(1-9) and from heavy-ion collisions of gold nuclei at relativistic energies(10,11) with microscopic nuclear theory calculations(12-17) to improve our understanding of dense matter. We find that the inclusion of heavy-ion collision data indicates an increase in the pressure in dense matter relative to previous analyses, shifting neutron-star radii towards larger values, consistent with recent observations by the Neutron Star Interior Composition Explorer mission(5-8,18). Our findings show that constraints from heavy-ion collision experiments show a remarkable consistency with multi-messenger observations and provide complementary information on nuclear matter at intermediate densities. This work combines nuclear theory, nuclear experiment and astrophysical observations, and shows how joint analyses can shed light on the properties of neutron-rich supranuclear matter over the density range probed in neutron stars.
Vences, Miguel ; Köhler, Jörn ; Crottini, Angelica ; Hofreiter, Michael ; Hutter, Carl R. ; du Preez, Louis ; Preick, Michaela ; Rakotoarison, Andolalao ; Rancilhac, Loïs ; Raselimanana, Achille P. ; Rosa, Gonçalo M. ; Scherz, Mark D. ; Glaw, Frank
The subgenus Laurentomantis in the genus Gephyromantis contains some of the least known amphibian species of Madagascar. The six currently valid nominal species are rainforest frogs known from few individuals, hampering a full understanding of the species diversity of the clade. We assembled data on specimens collected during field surveys over the past 30 years and integrated analysis of mitochondrial and nuclear-encoded genes of 88 individuals, a comprehensive bioacoustic analysis, and morphological comparisons to delimit a minimum of nine species-level lineages in the subgenus. To clarify the identity of the species Gephyromantis malagasius, we applied a target-enrichment approach to a sample of the 110 year old holotype of Microphryne malagasia Methuen and Hewitt, 1913 to assign this specimen to a lineage based on a mitochondrial DNA barcode. The holotype clustered unambiguously with specimens previously named G. ventrimaculatus. Consequently we propose to consider Trachymantis malagasia ventrimaculatus Angel, 1935 as a junior synonym of Gephyromantis malagasius. Due to this redefinition of G. malagasius, no scientific name is available for any of the four deep lineages of frogs previously subsumed under this name, all characterized by red color ventrally on the hindlimbs. These are here formally named as Gephyromantis fiharimpe sp. nov., G. matsilo sp. nov., G. oelkrugi sp. nov., and G. portonae sp. nov. The new species are distinguishable from each other by genetic divergences of >4% uncorrected pairwise distance in a fragment of the 16S rRNA marker and a combination of morphological and bioacoustic characters. Gephyromantis fiharimpe and G. matsilo occur, respectively, at mid-elevations and lower elevations along a wide stretch of Madagascar's eastern rainforest band, while G. oelkrugi and G. portonae appear to be more range-restricted in parts of Madagascar's North East and Northern Central East regions. Open taxonomic questions surround G. horridus, to which we here assign specimens from Montagne d'Ambre and the type locality Nosy Be; and G. ranjomavo, which contains genetically divergent populations from Marojejy, Tsaratanana, and Ampotsidy.
Vogel, Annemarie ; Claus, Inga ; Ahring, Sigrid ; Gruber, Doreen ; Haghikia, Aiden ; Frank, Ulrike ; Dziewas, Rainer ; Ebersbach, Georg ; Gandor, Florin ; Warnecke, Tobias
Background
Dysphagia is a major clinical concern in multiple system atrophy (MSA). A detailed evaluation of its major endoscopic features compared with Parkinson's disease (PD) is lacking.
Objective
This study systematically assessed dysphagia in MSA compared with PD and correlated subjective dysphagia to objective endoscopic findings.
Methods
Fifty-seven patients with MSA (median, 64 [interquartile range (IQR): 59-71] years; 35 women) underwent flexible endoscopic evaluation of swallowing using a specific MSA-flexible endoscopic evaluation of swallowing task protocol. Findings were compared with an age-matched cohort of 57 patients with PD (median, 67 [interquartile range: 60-73] years; 28 women). In a subcohort, subjective dysphagia was assessed using the Swallowing Disturbance Questionnaire and correlated to endoscopy findings.
Results
Patients with MSA predominantly showed symptoms suggestive of oral-phase disturbance (premature spillage, 75.4%, piecemeal deglutition, 75.4%). Pharyngeal-phase symptoms occurred less often (pharyngeal residues, 50.9%; penetration/aspiration, 28.1%). In contrast, pharyngeal symptoms were the most common finding in PD (pharyngeal residues, 47.4%). Oral symptoms occurred less frequently in PD (premature spillage, 15.8%, P < 0.001; piecemeal deglutition, 1.8%, P < 0.01). Patients with MSA had a greater risk for oral-phase disturbances with increased disease severity (P < 0.05; odds ratio, 3.15). Patients with MSA showed a significantly higher intraindividual interswallow variability compared with PD. When correlating Swallowing Disturbance Questionnaire scores with endoscopy results, its cutoff, validated for PD, was not sensitive enough to identify patients with MSA with dysphagia. We developed a subscore for identifying dysphagia in MSA and calculated a new cutoff (sensitivity 85%, specificity 100%).
Conclusions
In contrast with patients with PD, patients with dysphagic MSA more frequently present with oral-phase symptoms and a significantly higher intraindividual interswallow variability. A novel Swallowing Disturbance Questionnaire MSA subscore may be a valuable tool to identify patients with MSA with early oropharyngeal dysphagia.
Lupien, Rachel L. ; Russell, James M. ; Pearson, Emma J. ; Castaneda, Isla S. ; Asrat, Asfawossen ; Förster, Verena ; Lamb, Henry F. ; Roberts, Helen M. ; Schäbitz, Frank ; Trauth, Martin H. ; Beck, Catherine C. ; Feibel, Craig S. ; Cohen, Andrew S.
Understanding eastern African paleoclimate is critical for contextualizing early human evolution, adaptation, and dispersal, yet Pleistocene climate of this region and its governing mechanisms remain poorly understood due to the lack of long, orbitally-resolved, terrestrial paleoclimate records. Here we present leaf wax hydrogen isotope records of rainfall from paleolake sediment cores from key time windows that resolve long-term trends, variations, and high-latitude effects on tropical African precipitation. Eastern African rainfall was dominantly controlled by variations in low-latitude summer insolation during most of the early and middle Pleistocene, with little evidence that glacial-interglacial cycles impacted rainfall until the late Pleistocene. We observe the influence of high-latitude-driven climate processes emerging from the last interglacial (Marine Isotope Stage 5) to the present, an interval when glacial-interglacial cycles were strong and insolation forcing was weak. Our results demonstrate a variable response of eastern African rainfall to low-latitude insolation forcing and high-latitude-driven climate change, likely related to the relative strengths of these forcings through time and a threshold in monsoon sensitivity. We observe little difference in mean rainfall between the early, middle, and late Pleistocene, which suggests that orbitally-driven climate variations likely played a more significant role than gradual change in the relationship between early humans and their environment.
Health app policy
(2022)
Essen, Anna ; Stern, Ariel Dora ; Haase, Christoffer Bjerre ; Car, Josip ; Greaves, Felix ; Paparova, Dragana ; Vandeput, Steven ; Wehrens, Rik ; Bates, David W.
An abundant and growing supply of digital health applications (apps) exists in the commercial tech-sector, which can be bewildering for clinicians, patients, and payers. A growing challenge for the health care system is therefore to facilitate the identification of safe and effective apps for health care practitioners and patients to generate the most health benefit as well as guide payer coverage decisions. Nearly all developed countries are attempting to define policy frameworks to improve decision-making, patient care, and health outcomes in this context. This study compares the national policy approaches currently in development/use for health apps in nine countries. We used secondary data, combined with a detailed review of policy and regulatory documents, and interviews with key individuals and experts in the field of digital health policy to collect data about implemented and planned policies and initiatives. We found that most approaches aim for centralized pipelines for health app approvals, although some countries are adding decentralized elements. While the countries studied are taking diverse paths, there is nevertheless broad, international convergence in terms of requirements in the areas of transparency, health content, interoperability, and privacy and security. The sheer number of apps on the market in most countries represents a challenge for clinicians and patients. Our analyses of the relevant policies identified challenges in areas such as reimbursement, safety, and privacy and suggest that more regulatory work is needed in the areas of operationalization, implementation and international transferability of approvals. Cross-national efforts are needed around regulation and for countries to realize the benefits of these technologies.
Organizational commitments to equality change how people view women’s and men’s professional success
(2024)
To address women’s underrepresentation in high-status positions, many organizations have committed to gender equality. But is women’s professional success viewed less positively when organizations commit to women’s advancement? Do equality commitments have positive effects on evaluations of successful men? We fielded a survey experiment with a national probability sample in Germany (N = 3229) that varied employees’ gender and their organization’s commitment to equality. Respondents read about a recently promoted employee and rated how decisive of a role they thought intelligence and effort played in getting the employee promoted from 1 “Not at all decisive” to 7 “Very decisive” and the fairness of the promotion from 1 “Very unfair” to 7 “Very fair.” When organizations committed to women’s advancement rather than uniform performance standards, people believed intelligence and effort were less decisive in women’s promotions, but that intelligence was more decisive in men’s promotions. People viewed women’s promotions as least fair and men’s as most fair in organizations committed to women’s advancement. However, women’s promotions were still viewed more positively than men’s in all conditions and on all outcomes, suggesting people believed that organizations had double standards for success that required women to be smarter and work harder to be promoted, especially in organizations that did not make equality commitments.
Random logic networks
(2021)
We investigate dynamical properties of a quantum generalization of classical reversible Boolean networks. The state of each node is encoded as a single qubit, and classical Boolean logic operations are supplemented by controlled bit-flip and Hadamard operations. We consider synchronous updating schemes in which each qubit is updated at each step based on stored values of the qubits from the previous step. We investigate the periodic or quasiperiodic behavior of quantum networks, and we analyze the propagation of single site perturbations through the quantum networks with input degree one. A nonclassical mechanism for perturbation propagation leads to substantially different evolution of the Hamming distance between the original and perturbed states.
Mussel-inspired multifunctional coating for bacterial infection prevention and osteogenic induction
(2021)
Li, Mingjun ; Schlaich, Christoph ; Zhang, Jianguang ; Donskyi, Ievgen ; Schwibbert, Karin ; Schreiber, Frank ; Xia, Yi ; Radnik, Jörg ; Schwerdtle, Tanja ; Haag, Rainer
Bacterial infection and osteogenic integration are the two main problems that cause severe complications after surgeries. In this study, the antibacterial and osteogenic properties were simultaneously introduced in biomaterials, where copper nanoparticles (CuNPs) were generated by in situ reductions of Cu ions into a mussel-inspired hyperbranched polyglycerol (MI-hPG) coating via a simple dip-coating method. This hyperbranched polyglycerol with 10 % catechol groups' modification presents excellent antifouling property, which could effectively reduce bacteria adhesion on the surface. In this work, polycaprolactone (PCL) electrospun fiber membrane was selected as the substrate, which is commonly used in biomedical implants in bone regeneration and cardiovascular stents because of its good biocompatibility and easy post-modification. The as-fabricated CuNPs-incorporated PCL membrane [PCL-(MI-hPG)-CuNPs] was confirmed with effective antibacterial performance via in vitro antibacterial tests against Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), and multi-resistant E. coli. In addition, the in vitro results demonstrated that osteogenic property of PCL-(MI-hPG)-CuNPs was realized by upregulating the osteoblast-related gene expressions and protein activity. This study shows that antibacterial and osteogenic properties can be balanced in a surface coating by introducing CuNPs.
Esmaeilishirazifard, Elham ; Usher, Louise ; Trim, Carol ; Denise, Hubert ; Sangal, Vartul ; Tyson, Gregory H. ; Barlow, Axel ; Redway, Keith F. ; Taylor, John D. ; Kremyda-Vlachou, Myrto ; Davies, Sam ; Loftus, Teresa D. ; Lock, Mikaella M. G. ; Wright, Kstir ; Dalby, Andrew ; Snyder, Lori A. S. ; Wuster, Wolfgang ; Trim, Steve ; Moschos, Sterghios A.
Notwithstanding their 3 to 5% mortality, the 2.7 million envenomation-related injuries occurring annually-predominantly across Africa, Asia, and Latin America-are also major causes of morbidity. Venom toxin-damaged tissue will develop infections in some 75% of envenomation victims, with E. faecalis being a common culprit of disease; however, such infections are generally considered to be independent of envenomation.
Animal venoms are considered sterile sources of antimicrobial compounds with strong membrane-disrupting activity against multidrug-resistant bacteria.
However, venomous bite wound infections are common in developing nations. Investigating the envenomation organ and venom microbiota of five snake and two spider species, we observed venom community structures that depend on the host venomous animal species and evidenced recovery of viable microorganisms from black-necked spitting cobra (Naja nigricollis) and Indian ornamental tarantula (Poecilotheria regalis) venoms. Among the bacterial isolates recovered from N. nigricollis, we identified two venom-resistant, novel sequence types of Enterococcus faecalis whose genomes feature 16 virulence genes, indicating infectious potential, and 45 additional genes, nearly half of which improve bacterial membrane integrity.
Our findings challenge the dogma of venom sterility and indicate an increased primary infection risk in the clinical management of venomous animal bite wounds. IMPORTANCE Notwithstanding their 3 to 5% mortality, the 2.7 million envenomation-related injuries occurring annually-predominantly across Africa, Asia, and Latin America-are also major causes of morbidity. Venom toxin-damaged tissue will develop infections in some 75% of envenomation victims, with E. faecalis being a common culprit of disease; however, such infections are generally considered to be independent of envenomation. Here, we provide evidence on venom microbiota across snakes and arachnida and report on the convergent evolution mechanisms that can facilitate adaptation to black-necked cobra venom in two independent E. faecalis strains, easily misidentified by biochemical diagnostics.
Therefore, since inoculation with viable and virulence gene-harboring bacteria can occur during envenomation, acute infection risk management following envenomation is warranted, particularly for immunocompromised and malnourished victims in resource-limited settings.
These results shed light on how bacteria evolve for survival in one of the most extreme environments on Earth and how venomous bites must be also treated for infections.
Riemann, Lasse ; Rahav, Eyal ; Passow, Uta ; Grossart, Hans-Peter ; de Beer, Dirk ; Klawonn, Isabell ; Eichner, Meri ; Benavides, Mar ; Bar-Zeev, Edo
Biological dinitrogen (N-2) fixation is performed solely by specialized bacteria and archaea termed diazotrophs, introducing new reactive nitrogen into aquatic environments.
Conventionally, phototrophic cyanobacteria are considered the major diazotrophs in aquatic environments. However, accumulating evidence indicates that diverse non-cyanobacterial diazotrophs (NCDs) inhabit a wide range of aquatic ecosystems, including temperate and polar latitudes, coastal environments and the deep ocean. NCDs are thus suspected to impact global nitrogen cycling decisively, yet their ecological and quantitative importance remain unknown. Here we review recent molecular and biogeochemical evidence demonstrating that pelagic NCDs inhabit and thrive especially on aggregates in diverse aquatic ecosystems. Aggregates are characterized by reduced-oxygen microzones, high C:N ratio (above Redfield) and high availability of labile carbon as compared to the ambient water.
We argue that planktonic aggregates are important loci for energetically-expensive N-2 fixation by NCDs and propose a conceptual framework for aggregate-associated N-2 fixation. Future studies on aggregate-associated diazotrophy, using novel methodological approaches, are encouraged to address the ecological relevance of NCDs for nitrogen cycling in aquatic environments.
We apply the concepts of relative dimensions and mutual singularities to characterize the fractal properties of overlapping attractor and repeller in chaotic dynamical systems. We consider one analytically solvable example (a generalized baker's map); two other examples, the Anosov-Mobius and the Chirikov-Mobius maps, which possess fractal attractor and repeller on a two-dimensional torus, are explored numerically. We demonstrate that although for these maps the stable and unstable directions are not orthogonal to each other, the relative Renyi and Kullback-Leibler dimensions as well as the mutual singularity spectra for the attractor and repeller can be well approximated under orthogonality assumption of two fractals.
Milde, Peter ; Langenhorst, Malte ; Hölscher, Hendrik ; Rottmann-Matthes, Jens ; Hundertmark, Dirk ; Eng, Lukas ; Hoffmann-Vogel, Regina
The fundamental sensitivity limit of atomic force microscopy is strongly correlated to the thermal noise of cantilever oscillation. A method to suppress this unwanted noise is to reduce the bandwidth of the measurement, but this approach is limited by the speed of the measurement and the width of the cantilever resonance, commonly defined through the quality factor Q. However, it has been shown that optomechanical resonances in interferometers might affect cantilever oscillations resulting in an effective quality factor Q(eff). When the laser power is sufficiently increased cantilever oscillations might even reach the regime of self-oscillation. In this self-oscillation state, the noise of the system is partially determined by the interaction with laser light far from equilibrium. Here, we show and discuss how tuning of laser power leads to nonlinear optomechanical effects that can dramatically increase the effective quality factor of the cantilever leading to out-of-equilibrium noise. We model the effects using a fourth order nonlinearity of the damping coefficient. Published under an exclusive license by AIP Publishing.
We examine how the gender of business owners is related to the wages paid to female relative to male employees working in their firms. Using Finnish register data and employing firm fixed effects, we find that the gender pay gap is—starting from a gender pay gap of 11 to 12%—two to three percentage points lower for hourly wages in female-owned firms than in male-owned firms. Results are robust to how the wage is measured, as well as to various further robustness checks. More importantly, we find substantial differences between industries. While, for instance, in the manufacturing sector, the gender of the owner plays no role in the gender pay gap, in several service sector industries, like ICT or business services, no or a negligible gender pay gap can be found, but only when firms are led by female business owners. Businesses with male ownership maintain a gender pay gap of around 10% also in the latter industries. With increasing firm size, the influence of the gender of the owner, however, fades. In large firms, it seems that others—firm managers—determine wages and no differences in the pay gap are observed between male- and female-owned firms.
Larix species range dynamics in Siberia since the Last Glacial captured from sedimentary ancient DNA
(2022)
Schulte, Luise ; Meucci, Stefano ; Stoof-Leichsenring, Kathleen R. ; Heitkam, Tony ; Schmidt, Nicola ; von Hippel, Barbara ; Andreev, Andrei A. ; Diekmann, Bernhard ; Biskaborn, Boris ; Wagner, Bernd ; Melles, Martin ; Pestryakova, Lyudmila A. ; Alsos, Inger G. ; Clarke, Charlotte ; Krutovsky, Konstantin ; Herzschuh, Ulrike
Climate change is expected to cause major shifts in boreal forests which are in vast areas of Siberia dominated by two species of the deciduous needle tree larch (Larix). The species differ markedly in their ecosystem functions, thus shifts in their respective ranges are of global relevance.
However, drivers of species distribution are not well understood, in part because paleoecological data at species level are lacking. This study tracks Larix species distribution in time and space using target enrichment on sedimentary ancient DNA extracts from eight lakes across Siberia. We discovered that Larix sibirica, presently dominating in western Siberia, likely migrated to its northern distribution area only in the Holocene at around 10,000 years before present (ka BP), and had a much wider eastern distribution around 33 ka BP. Samples dated to the Last Glacial Maximum (around 21 ka BP), consistently show genotypes of L. gmelinii.
Our results suggest climate as a strong determinant of species distribution in Larix and provide temporal and spatial data for species projection in a changing climate.
Using ancient sedimentary DNA from up to 50 kya, dramatic distributional shifts are documented in two dominant boreal larch species, likely guided by environmental changes suggesting climate as a strong determinant of species distribution.
Money matters!
(2024)
This paper examines the context dependency of attitudes toward maternal employment. We test three sets of factors that may affect these attitudes—economic benefits, normative obligations, and child-related consequences—by analyzing data from a unique survey experimental design implemented in a large-scale household panel survey in Germany (17,388 observations from 3,494 respondents). Our results show that the economic benefits associated with maternal employment are the most important predictor of attitudes supporting maternal employment. Moreover, we find that attitudes toward maternal employment vary by individual, household, and contextual characteristics (in particular, childcare quality). We interpret this variation as an indication that negative attitudes toward maternal employment do not necessarily reflect gender essentialism; rather, gender role attitudes are contingent upon the frames individuals have in mind.
Governments engage in corporatization by creating corporate entities or reorganizing existing ones. These corporatization activities reflect an interplay between political agency and environmental pressures, including (changing) notions of state-market relations. This paper discusses two ideal-typed organizational models of corporatization: the state as a marketizer and the marketization of the state. Whereas the first emphasizes the role of political design and agency in corporatization, the second emphasizes the role of (actors in) the environment for corporatization. Both models are assessed across five corporatization episodes in Norway and Sweden, where we also demonstrate the interplay between political agency and environmental pressure.
Estival, Séverine ; Chevalère, Johann ; Laurier, Virginie ; Mourre, Fabien ; Tricot, Julie ; Postal, Virginie
Background:
Prader-Willi syndrome (PWS) is a complex developmental genetic disorder associated with intellectual disability and deficits in executive functions which result in disorganisation and poor personal autonomy.
Aims:
This study aimed to determine impairments in planning skills of adults with PWS, in relation with their intellectual disabilities, as well as the influence of food compulsions on their performance.
Methods and procedures:
A modified version of the Zoo Map from the Behavioural Assessment of the Dysexecutive Syndrome was used in three groups: a group of adults with PWS in comparison with two groups both matched on chronological age, one with typical development (TD) and one with intellectual disability (ID).
Outcomes and results:
Compared to TD adults, both adults with PWS and ID showed increased planning time and lower raw scores on the planning task. The execution time and the number of errors were higher in the PWS group compared to the comparison groups. All three groups performed worse in the non-food condition only for number of errors and raw score.
Conclusions and implications:
Planning abilities were impaired in PWS adults. Results also showed that intellectual level plays a role in participants' performance. These findings are essential to understand the difficulties of people with PWS daily life.
Systematic review and meta-analysis of ex-post evaluations on the effectiveness of carbon pricing
(2024)
Döbbeling-Hildebrandt, Niklas ; Miersch, Klaas ; Khanna, Tarun M. ; Bachelet, Marion ; Bruns, Stephan B. ; Callaghan, Max ; Edenhofer, Ottmar ; Flachsland, Christian ; Forster, Piers M. ; Kalkuhl, Matthias ; Koch, Nicolas ; Lamb, William F. ; Ohlendorf, Nils ; Steckel, Jan Christoph ; Minx, Jan C.
Today, more than 70 carbon pricing schemes have been implemented around the globe, but their contributions to emissions reductions remains a subject of heated debate in science and policy. Here we assess the effectiveness of carbon pricing in reducing emissions using a rigorous, machine-learning assisted systematic review and meta-analysis. Based on 483 effect sizes extracted from 80 causal ex-post evaluations across 21 carbon pricing schemes, we find that introducing a carbon price has yielded immediate and substantial emission reductions for at least 17 of these policies, despite the low level of prices in most instances. Statistically significant emissions reductions range between –5% to –21% across the schemes (–4% to –15% after correcting for publication bias). Our study highlights critical evidence gaps with regard to dozens of unevaluated carbon pricing schemes and the price elasticity of emissions reductions. More rigorous synthesis of carbon pricing and other climate policies is required across a range of outcomes to advance our understanding of “what works” and accelerate learning on climate solutions in science and policy.
Data-driven expectations for electromagnetic counterpart searches based on LIGO/Virgo public alerts
(2022)
Petrov, Polina ; Singer, Leo P. ; Coughlin, Michael W. ; Kumar, Vishwesh ; Almualla, Mouza ; Anand, Shreya ; Bulla, Mattia ; Dietrich, Tim ; Foucart, Francois ; Guessoum, Nidhal
Searches for electromagnetic counterparts of gravitational-wave signals have redoubled since the first detection in 2017 of a binary neutron star merger with a gamma-ray burst, optical/infrared kilonova, and panchromatic afterglow. Yet, one LIGO/Virgo observing run later, there has not yet been a second, secure identification of an electromagnetic counterpart. This is not surprising given that the localization uncertainties of events in LIGO and Virgo's third observing run, O3, were much larger than predicted.
We explain this by showing that improvements in data analysis that now allow LIGO/Virgo to detect weaker and hence more poorly localized events have increased the overall number of detections, of which well-localized, gold-plated events make up a smaller proportion overall.
We present simulations of the next two LIGO/Virgo/KAGRA observing runs, O4 and O5, that are grounded in the statistics of O3 public alerts. To illustrate the significant impact that the updated predictions can have, we study the follow-up strategy for the Zwicky Transient Facility. Realistic and timely forecasting of gravitational-wave localization accuracy is paramount given the large commitments of telescope time and the need to prioritize which events are followed up.
We include a data release of our simulated localizations as a public proposal planning resource for astronomers.
López-Sánchez, Aida ; Bareth, Georg ; Bolten, Andreas ; Rose, Laura E. ; Mansfeldt, Tim ; Sapp, Melanie ; Linstädter, Anja
Mediterranean oak woodlands are currently facing unprecedented degradation threats from oak decline. The Iberian oak decline "Seca", related to Phytophthora infection, causes crown defoliation that may adversely affect ecosystem services (ESs). We aim to improve our understanding of how Seca-induced declines in crown foliation affect the provision of multiple ecosystem services from understory vegetation. We selected holm (Quercus ilex) and cork oak (Q. suber) trees in a Spanish oak woodland and evaluated three proxies of canopy effects. One proxy (crown defoliation) solely captured Seca-dependent effects, one proxy solely captured Seca-independent effects (tree dimensions such as diameter and height), while the third proxy (tree vigor) captured overall canopy effects. We then used the best-performing proxies to assess canopy effects on key ecosystem services (ESs) such as aboveground net primary production (ANPP), grass and legume biomass, species diversity, litter decomposition rates, and a combined index of ecosystem multifunctionality. <br /> We found that both types of canopy effects (i.e. Seca-dependent and Seca-independent effects) were related, indicating that ANPP was disproportionally more affected by Seca when defoliated trees were large. Responses of other ESs were mostly not significant, although lower species diversity was found under trees with intermediate vigor. Our results underline that a Seca-related decline in canopy density triggered a homogenization of ecosystem service delivery on the ecosystem scale. The ecosystem functions (EFs) under trees of low vigor are similar to that in adjacent open microsites indicating that the presence of vigorous (i.e. old and vital) trees is critical for maintaining EFs at a landscape level. Our results also highlight the importance of quantifying not only defoliation but also tree dimensions as both factors jointly and interactively modify canopy effects on ecosystem multifunctionality.
Nguyen, Dong Hai Phuong ; Georgie, Yasmin Kim ; Kayhan, Ezgi ; Eppe, Manfred ; Hafner, Verena Vanessa ; Wermter, Stefan
Safe human-robot interactions require robots to be able to learn how to behave appropriately in spaces populated by people and thus to cope with the challenges posed by our dynamic and unstructured environment, rather than being provided a rigid set of rules for operations. In humans, these capabilities are thought to be related to our ability to perceive our body in space, sensing the location of our limbs during movement, being aware of other objects and agents, and controlling our body parts to interact with them intentionally. Toward the next generation of robots with bio-inspired capacities, in this paper, we first review the developmental processes of underlying mechanisms of these abilities: The sensory representations of body schema, peripersonal space, and the active self in humans. Second, we provide a survey of robotics models of these sensory representations and robotics models of the self; and we compare these models with the human counterparts. Finally, we analyze what is missing from these robotics models and propose a theoretical computational framework, which aims to allow the emergence of the sense of self in artificial agents by developing sensory representations through self-exploration.
Dunker, Susanne ; Boyd, Matthew ; Durka, Walter ; Erler, Silvio ; Harpole, W. Stanley ; Henning, Silvia ; Herzschuh, Ulrike ; Hornick, Thomas ; Knight, Tiffany ; Lips, Stefan ; Mäder, Patrick ; Švara, Elena Motivans ; Mozarowski, Steven ; Rakosy, Demetra ; Römermann, Christine ; Schmitt-Jansen, Mechthild ; Stoof-Leichsenring, Kathleen ; Stratmann, Frank ; Treudler, Regina ; Virtanen, Risto ; Wendt-Potthoff, Katrin ; Wilhelm, Christian
Environmental monitoring involves the quantification of microscopic cells and particles such as algae, plant cells, pollen, or fungal spores. Traditional methods using conventional microscopy require expert knowledge, are time-intensive and not well-suited for automated high throughput. Multispectral imaging flow cytometry (MIFC) allows measurement of up to 5000 particles per second from a fluid suspension and can simultaneously capture up to 12 images of every single particle for brightfield and different spectral ranges, with up to 60x magnification. The high throughput of MIFC has high potential for increasing the amount and accuracy of environmental monitoring, such as for plant-pollinator interactions, fossil samples, air, water or food quality that currently rely on manual microscopic methods. Automated recognition of particles and cells is also possible, when MIFC is combined with deep-learning computational techniques. Furthermore, various fluorescence dyes can be used to stain specific parts of the cell to highlight physiological and chemical features including: vitality of pollen or algae, allergen content of individual pollen, surface chemical composition (carbohydrate coating) of cells, DNA- or enzyme-activity staining. Here, we outline the great potential for MIFC in environmental research for a variety of research fields and focal organisms. In addition, we provide best practice recommendations.
DeFelipe, Irene ; Alcalde, Juan ; Baykiev, Eldar ; Bernal, Isabel ; Boonma, Kittiphon ; Carbonell, Ramon ; Flude, Stephanie ; Folch, Arnau ; Fullea, Javier ; García-Castellanos, Daniel ; Geyer, Adelina ; Giralt, Santiago ; Hernández, Armand ; Jiménez-Munt, Ivone ; Kumar, Ajay ; Llorens, Maria-Gema ; Martí, Joan ; Molina, Cecilia ; Olivar-Castaño, Andrés ; Parnell, Andrew ; Schimmel, Martin ; Torné, Montserrat ; Ventosa, Sergi
The immense advances in computer power achieved in the last decades have had a significant impact in Earth science, providing valuable research outputs that allow the simulation of complex natural processes and systems, and generating improved forecasts. The development and implementation of innovative geoscientific software is currently evolving towards a sustainable and efficient development by integrating models of different aspects of the Earth system. This will set the foundation for a future digital twin of the Earth. The codification and update of this software require great effort from research groups and therefore, it needs to be preserved for its reuse by future generations of geoscientists. Here, we report on Geo-Soft-CoRe, a Geoscientific Software & Code Repository, hosted at the archive DIGITAL.CSIC. This is an open source, multidisciplinary and multiscale collection of software and code developed to analyze different aspects of the Earth system, encompassing tools to: 1) analyze climate variability; 2) assess hazards, and 3) characterize the structure and dynamics of the solid Earth. Due to the broad range of applications of these software packages, this collection is useful not only for basic research in Earth science, but also for applied research and educational purposes, reducing the gap between the geosciences and the society. By providing each software and code with a permanent identifier (DOI), we ensure its self-sustainability and accomplish the FAIR (Findable, Accessible, Interoperable and Reusable) principles. Therefore, we aim for a more transparent science, transferring knowledge in an easier way to the geoscience community, and encouraging an integrated use of computational infrastructure.
Groh, Jannis ; Diamantopoulos, Efstathios ; Duan, Xiaohong ; Ewert, Frank ; Heinlein, Florian ; Herbst, Michael ; Holbak, Maja ; Kamali, Bahareh ; Kersebaum, Kurt-Christian ; Kuhnert, Matthias ; Nendel, Claas ; Priesack, Eckart ; Steidl, Jörg ; Sommer, Michael ; Pütz, Thomas ; Vanderborght, Jan ; Vereecken, Harry ; Wallor, Evelyn ; Weber, Tobias K. D. ; Wegehenkel, Martin ; Weihermüller, Lutz ; Gerke, Horst H.
Crop model intercomparison studies have mostly focused on the assessment of predictive capabilities for crop development using weather and basic soil data from the same location. Still challenging is the model performance when considering complex interrelations between soil and crop dynamics under a changing climate. The objective of this study was to test the agronomic crop and environmental flux-related performance of a set of crop models. The aim was to predict weighing lysimeter-based crop (i.e., agronomic) and water-related flux or state data (i.e., environmental) obtained for the same soil monoliths that were taken from their original environment and translocated to regions with different climatic conditions, after model calibration at the original site. Eleven models were deployed in the study. The lysimeter data (2014-2018) were from the Dedelow (Dd), Bad Lauchstadt (BL), and Selhausen (Se) sites of the TERENO (TERrestrial ENvironmental Observatories) SOILCan network. Soil monoliths from Dd were transferred to the drier and warmer BL site and the wetter and warmer Se site, which allowed a comparison of similar soil and crop under varying climatic conditions. The model parameters were calibrated using an identical set of crop- and soil-related data from Dd. Environmental fluxes and crop growth of Dd soil were predicted for conditions at BL and Se sites using the calibrated models. The comparison of predicted and measured data of Dd lysimeters at BL and Se revealed differences among models. At site BL, the crop models predicted agronomic and environmental components similarly well. Model performance values indicate that the environmental components at site Se were better predicted than agronomic ones. The multi-model mean was for most observations the better predictor compared with those of individual models. For Se site conditions, crop models failed to predict site-specific crop development indicating that climatic conditions (i.e., heat stress) were outside the range of variation in the data sets considered for model calibration. For improving predictive ability of crop models (i.e., productivity and fluxes), more attention should be paid to soil-related data (i.e., water fluxes and system states) when simulating soil-crop-climate interrelations in changing climatic conditions.
Cao, Xianyong ; Chen, Jianhui ; Tian, Fang ; Xu, Qinghai ; Herzschuh, Ulrike ; Telford, Richard ; Huang, Xiaozhong ; Zheng, Zhuo ; Shen, Caiming ; Li, Wenjia
Wittenbecher, Clemens ; Cuadrat, Rafael ; Johnston, Luke ; Eichelmann, Fabian ; Jäger, Susanne ; Kuxhaus, Olga ; Prada, Marcela ; Del Greco, Fabiola M. ; Hicks, Andrew A. ; Hoffman, Per ; Krumsiek, Jan ; Hu, Frank B. ; Schulze, Matthias B.
Metabolic alterations precede cardiometabolic disease onset. Here we present ceramide- and dihydroceramide-profiling data from a nested case-cohort (type 2 diabetes [T2D, n = 775]; cardiovascular disease [CVD, n = 551]; random subcohort [n = 1137]) in the prospective EPIC-Potsdam study. We apply the novel NetCoupler-algorithm to link a data-driven (dihydro)ceramide network to T2D and CVD risk. Controlling for confounding by other (dihydro)ceramides, ceramides C18:0 and C22:0 and dihydroceramides C20:0 and C22:2 are associated with higher and ceramide C20:0 and dihydroceramide C26:1 with lower T2D risk. Ceramide C16:0 and dihydroceramide C22:2 are associated with higher CVD risk. Genome-wide association studies and Mendelian randomization analyses support a role of ceramide C22:0 in T2D etiology. Our results also suggest that (dh)ceramides partly mediate the putative adverse effect of high red meat consumption and benefits of coffee consumption on T2D risk. Thus, (dihydro)ceramides may play a critical role in linking genetic predisposition and dietary habits to cardiometabolic disease risk.
“Ick bin een Berlina”
(2024)
Background: Robots are increasingly used as interaction partners with humans. Social robots are designed to follow expected behavioral norms when engaging with humans and are available with different voices and even accents. Some studies suggest that people prefer robots to speak in the user’s dialect, while others indicate a preference for different dialects.
Methods: Our study examined the impact of the Berlin dialect on perceived trustworthiness and competence of a robot. One hundred and twenty German native speakers (Mage = 32 years, SD = 12 years) watched an online video featuring a NAO robot speaking either in the Berlin dialect or standard German and assessed its trustworthiness and competence.
Results: We found a positive relationship between participants’ self-reported Berlin dialect proficiency and trustworthiness in the dialect-speaking robot. Only when controlled for demographic factors, there was a positive association between participants’ dialect proficiency, dialect performance and their assessment of robot’s competence for the standard German-speaking robot. Participants’ age, gender, length of residency in Berlin, and device used to respond also influenced assessments. Finally, the robot’s competence positively predicted its trustworthiness.
Discussion: Our results inform the design of social robots and emphasize the importance of device control in online experiments.
Germany’s relatively stable party system faces a new left-authoritarian challenger: Sahra Wagenknecht’s Bündnis Sahra Wagenknecht (BSW) party. First polls indicate that for the BSW, election results above 10% are within reach. While Wagenknecht’s positions in economic and cultural terms have already been discussed, this article elaborates on another highly relevant feature of Wagenknecht, namely her populist communication. Exploring Wagenknecht’s and BSW’s populist appeal helps us to understand why the party is said to also have potential among seemingly different voter groups coming from the far right Alternative for Germany (AfD) and far left Die Linke, which share high levels of populist attitudes. To analyse the role that populist communication plays for Wagenknecht and the BSW, this article combines quantitative and qualitative methods. The quantitative analysis covers all speeches (10,000) and press releases (19,000) published by Die Linke members of Parliament (MPs; 2005–2023). The results show that Wagenknecht is the (former) Die Linke MP with the highest share of populist communication. Furthermore, she was also able to convince a group of populist MPs to join the BSW. The article closes with a qualitative analysis of BSW’s manifesto that reveals how populist framing plays a major role in this document, in which the political and economic elites are accused of working against the interest of “the majority”. Based on this analysis, the classification of the BSW as a populist party seems to be appropriate.
We use worldwide gridded satellite data to analyse how population size and density affect urban PM 2.5 pollution. We find that more populated and denser grid cells are more exposed to pollution. However, across urban areas, exposure increases with cities’ population size but decreases with density. Moreover, the population effect is driven mostly by population commuting to core cities rather than the core city population itself. We analyse heterogeneity by geography and income levels. A counterfactual simulation shows that exposure could fall by up to 40% if population size were equalized across all cities within countries, but the relocation of population from large to small cities that maximizes welfare would be small.
The Final-over-Final Condition has emerged as a robust and explanatory generalization for a wide range of phenomena (Biberauer, Holmberg, and Roberts 2014, Sheehan et al. 2017).
In this article, we argue that it also holds in another domain, nominalization.
In languages that show overt nominalization of VPs, one word order is routinely unattested, namely, a head-initial VP with a suffixal nominalizer.
This typological gap can be accounted for by the Final-over-Final Condition, if we allow it to hold within mixed extended projections.
This view also makes correct predictions about agentive nominalizations and nominalized serial verb constructions.
Motivational profiles across domains and academic choices within Eccles et al.’s situated expectancy
(2021)
Lazarides, Rebecca ; Dicke, Anna-Lena ; Rubach, Charlott ; Oppermann, Elisa ; Eccles, Jacquelynne S.
This longitudinal person-centered study aimed to identify profiles of subjective task values and ability self-concepts of adolescents in the domain of mathematics, English, biology, and physics in Grades 10 and 12. We were interested in gendered changes of profile membership, and in relations between profile membership and educational and occupational outcomes in adulthood. Data were drawn from the Michigan Study of Adolescent and Adult Life Transitions. We focused on students who participated in the data collection in Grades 10 and 12 (N = 911; 56.1% female; M-age = 16.49, SD = .63; 91.2% European American, 4.6% African American, and 2.1% other ethnic groups such as Hispanic, Asian, Native American). Data on subsequent college majors were assessed 2, 6, and 10 years after finishing high school and data on occupational outcomes was assessed up to 22 years after high school. Using Latent Profile Analyses, our findings revealed five profiles in grade 10 and four profiles in grade 12, which were meaningfully related to student gender. Latent Transition Analyses showed that motivational beliefs became more hierarchical over time. Gendered changes in profile membership occurred, with boys experiencing a process of specialization into mathematics domains. We were also able to show that gender-specific intraindividual hierarchies of motivational beliefs were related to gender-specific specialization processes in adolescence and to subsequent gendered choices throughout the life course.
Kollmann, Peter ; Roussos, Elias ; Clark, George ; Cooper, John F. ; Sturner, Steven J. ; Kotova, Anna ; Regoli, Leonardo ; Shprits, Yuri Y. ; Aseev, Nikita ; Krupp, Norbert
Saturn is permanently surrounded by 6 discrete proton radiation belts that are rigidly separated by the orbits of its inner moons and dense rings. These radiation belts are ideal environments to study the details of radial diffusion and the CRAND source process, yet progress has been hindered by the fact that the energy spectra are not known with certainty: Reanalysis of the response functions of the LEMMS instrument on-board the Cassini orbiter has shown that measurements of less than or similar to 10 MeV protons may be easily contaminated by greater than or similar to 10 MeV protons and that many available measurements characterize a very broad energy range, so that the calculation of an energy-resolved spectrum is not as straightforward as previously assumed. Here we use forward modeling of the measurements based on the instrument response and combine this technique where useful with numerical modeling of the proton belt physics in order to determine Saturn's spectra with higher certainty. We find significant proton intensities up to approximate to 1 GeV. While earlier studies reported on proton spectra roughly following a power law with exponent approximate to -2, our more advanced analysis shows harder spectra with exponent approximate to -1. The observed spectra provide independent confirmation that Saturn's proton belts are sourced by CRAND and are consistent with the provided protons being subsequently cooled in the tenuous gas originating from Saturn or Enceladus. The intensities at Saturn are found to be lower than at Jupiter and Earth, which is also consistent with the source of Saturn being exclusively CRAND, while the other planets can draw from additional processes. Our new spectra can be used in the future to further our understanding of Saturn's proton belts and the respective physical processes that occur at other magnetized planets in general. Also, the spectra have applications for several topics of planetary science, such as space weathering of Saturn's moons and rings, and can be useful to constrain properties of the main rings through their production of secondary particles.
Rosa, Angelika D. ; Dewaele, Agnès ; Garbarino, Gaston ; Svitlyk, Volodymyr ; Morard, Guillaume ; De Angelis, Filippo ; Krstulovic, Marija ; Briggs, Richard ; Irifune, Tetsuo ; Mathon, Olivier ; Bouhifd, Mohamed Ali
The martensitic transformation is a fundamental physical phenomenon at the origin of important industrial applications. However, the underlying microscopic mechanism, which is of critical importance to explain the outstanding mechanical properties of martensitic materials, is still not fully understood. This is because for most martensitic materials the transformation is a fast process that makes in situ studies extremely challenging. Noble solids krypton and xenon undergo a progressive pressure-induced face-centered cubic (fcc) to hexagonal close-packed (hcp) martensitic transition with a very wide coexistence domain. Here, we took advantage of this unique feature to study the detailed transformation progress at the atomic level by employing in situ x-ray diffraction and absorption spectroscopy. We evidenced a four-stage pathway and suggest that the lattice mismatch between the fcc and hcp forms plays a key role in the generation of strain. We also determined precisely the effect of the transformation on the compression behavior of these materials.
Raman spectroscopic quantification of tetrahedral boron in synthetic aluminum-rich tourmaline
(2021)
Kutzschbach, Martin ; Wunder, Bernd ; Wannhoff, Iris ; Wilke, Franziska Daniela Helena ; Couffignal, Frédéric ; Rocholl, Alexander
The Raman spectra of five B-[4]-bearing tourmalines of different composition synthesized at 700 degrees C/4.0 GPa (including first-time synthesis of Na-Li-B-[4]-tourmaline, Ca-Li-B-[4]-tourmaline, and Ca-bearing square-B-[4]-tourmaline) reveal a strong correlation between the tetrahedral boron content and the summed relative intensity of all OH-stretching bands between 3300-3430 cm(-1). The band shift to low wavenumbers is explained by strong O3-H center dot center dot center dot O5 hydrogen bridge bonding. Applying the regression equation to natural B-[4]-bearing tourmaline from the Koralpe (Austria) reproduces the EMPA-derived value perfectly [EMPA: 0.67(12) B-[4] pfu vs. Raman: 0.66(13) B-[4] pfu]. This demonstrates that Raman spectroscopy provides a fast and easy-to-use tool for the quantification of tetrahedral boron in tourmaline. The knowledge of the amount of tetrahedral boron in tourmaline has important implications for the better understanding and modeling of B-isotope fractionation between tourmaline and fluid/melt, widely used as a tracer of mass transfer processes.
Dysfunctional islets of Langerhans are a hallmark of type 2 diabetes (T2D). We hypothesize that differences in islet gene expression alternative splicing which can contribute to altered protein function also participate in islet dysfunction. RNA sequencing (RNAseq) data from islets of obese diabetes-resistant and diabetes-susceptible mice were analyzed for alternative splicing and its putative genetic and epigenetic modulators. We focused on the expression levels of chromatin modifiers and SNPs in regulatory sequences. We identified alternative splicing events in islets of diabetes-susceptible mice amongst others in genes linked to insulin secretion, endocytosis or ubiquitin-mediated proteolysis pathways. The expression pattern of 54 histones and chromatin modifiers, which may modulate splicing, were markedly downregulated in islets of diabetic animals. Furthermore, diabetes-susceptible mice carry SNPs in RNA-binding protein motifs and in splice sites potentially responsible for alternative splicing events. They also exhibit a larger exon skipping rate, e.g., in the diabetes gene Abcc8, which might affect protein function. Expression of the neuronal splicing factor Srrm4 which mediates inclusion of microexons in mRNA transcripts was markedly lower in islets of diabetes-prone compared to diabetes-resistant mice, correlating with a preferential skipping of SRRM4 target exons. The repression of Srrm4 expression is presumably mediated via a higher expression of miR-326-3p and miR-3547-3p in islets of diabetic mice. Thus, our study suggests that an altered splicing pattern in islets of diabetes-susceptible mice may contribute to an elevated T2D risk.
Farkas, Márton Pál ; Hofmann, Hannes ; Zimmermann, Günter ; Zang, Arno ; Bethmann, Falko ; Meier, Peter ; Cottrell, Mark ; Josephson, Neal
In this study, we investigate numerically the hydro-mechanical behavior of fractured crystalline rock due to one of the five hydraulic stimulations at the Pohang Enhanced Geothermal site in South Korea. We use the commercial code FracMan (Golder Associates) that enables studying hydro-mechanical coupled processes in fractured media in three dimensions combining the finite element method with a discrete fracture network. The software is used to simulate fluid pressure perturbation at fractures during hydraulic stimulation. Our numerical simulation shows that pressure history matching can be obtained by partitioning the treatment into separate phases. This results in adjusted stress-aperture relationships. The evolution of aperture adjustment implies that the stimulation mechanism could be a combination of hydraulic fracturing and shearing. The simulated extent of the 0.01 MPa overpressure contour at the end of the treatment equals to similar to 180 m around the injection point.
Sedaghatmehr, Mastoureh ; Thirumalaikumar, Venkatesh P. ; Kamranfar, Iman ; Schulz, Karina ; Müller-Röber, Bernd ; Sampathkumar, Arun ; Balazadeh, Salma
Moderate and temporary heat stresses prime plants to tolerate, and survive, a subsequent severe heat stress. Such acquired thermotolerance can be maintained for several days under normal growth conditions, and can create a heat stress memory. We recently demonstrated that plastid-localized small heat shock protein 21 ( HSP21) is a key component of heat stress memory in Arabidopsis thaliana. A sustained high abundance of HSP21 during the heat stress recovery phase extends heat stress memory. The level of HSP21 is negatively controlled by plastid-localized metalloprotease FtsH6 during heat stress recovery. Here, we demonstrate that autophagy, a cellular recycling mechanism, exerts additional control over HSP21 degradation. Genetic and chemical disruption of both metalloprotease activity and autophagy trigger superior HSP21 accumulation, thereby improving memory. Furthermore, we provide evidence that autophagy cargo receptor ATG8-INTERACTING PROTEIN1 (ATI1) is associated with heat stress memory. ATI1 bodies co-localize with both autophagosomes and HSP21, and their abundance and transport to the vacuole increase during heat stress recovery. Together, our results provide new insights into the module for control of the regulation of heat stress memory, in which two distinct protein degradation pathways act in concert to degrade HSP21, thereby enabling cells to recover from the heat stress effect at the cost of reducing the heat stress memory.
Protecting the vulnerable
(2021)
Contemporary pressures of climate change and migration are abetting the spread of (re)emerging infectious diseases (EIDs), including HIV, Ebola and tuberculosis (TB). While the fact remains that any person can become infected, those most affected are vulnerable populations. In Eastern and Southern Africa (ESA) these include marginalized groups such as people who sell sex, LGBTI and MSM, but more widely also adolescents. Adolescents and young adults represent a particularly vulnerable group, caught as they are on the cusp between child protections and adult citizenship claims, including to health and educational provisions and protections. Without, or with incomplete claims, members of marginalized and vulnerable communities are excluded from access to provisions and protections of health as part of human security, whether out of apathy, fear or jurisdiction or through (deliberate) neglect.
The chapter proceeds through the framework of human security, which puts the security of individuals at the centre of its analysis. This stands in contrast to the 1990s securitization argument which framed HIV as a threat to state security. This chapter analyzes unique challenges of vulnerable adolescent populations as these relate to HIV prevention and treatment access. In doing so, it pays special heed to the “double vulnerability” of non-citizenship and compromised citizenship among this cohort. By invoking the human security paradigm, this chapter explores HIV interventions as they pertain to and aim to protect vulnerable populations beyond borders.
Schaerer, Daniel ; Izotov, Yuri I. ; Worseck, Gábor ; Berg, Danielle ; Chisholm, John ; Jaskot, Anne ; Nakajima, Kimihiko ; Ravindranath, Swara ; Thuan, Trinh X. ; Verhamme, Anne
Using the Space Telescope Imaging Spectrograph, we have obtained ultraviolet spectra from similar to 1200 to 2000 angstrom of known Lyman continuum (LyC) emitting galaxies at low redshift (z similar to 0.3-0.4) with varying absolute LyC escape fractions ( f(esc) similar to 0.01-0.72). Our observations include in particular the galaxy J1243+4646, which has the highest known LyC escape fraction at low redshift. While all galaxies are known Lyman alpha emitters, we consistently detect an inventory of additional emission lines, including C IV lambda 1550, He II lambda 1640, O III] lambda 1666, and C III] lambda 1909, whose origin is presumably essentially nebular. C IV lambda 1550 emission is detected above 4 sigma in six out of eight galaxies, with equivalent widths of EW(C IV) = 12-15 angstrom for two galaxies, which exceeds the previously reported maximum emission in low-z star-forming galaxies. We detect C IV lambda 1550 emission in all LyC emitters with escape fractions f(esc) > 0.1 and find a tentative increase in the flux ratio C IV lambda 1550 /C III] lambda 1909 with f(esc). Based on the data, we propose a new criterion to select and classify strong leakers (galaxies with f(esc) > 0.1): C IV lambda 1550 /C III] lambda 1909 greater than or similar to 0.75. Finally, we also find He II lambda 1640 emission in all the strong leakers with equivalent widths from 3 to 8 angstrom rest frame. These are among the highest values observed in star-forming galaxies and are primarily due to a high rate of ionizing photon production. The nebular He II lambda 1640 emission of the strong LyC emitters does not require harder ionizing spectra at >54 eV compared to those of typical star-forming galaxies at similarly low metallicity.
Birukov, Anna ; Glintborg, Dorte ; Schulze, Matthias B. ; Jensen, Tina K. ; Kuxhaus, Olga ; Andersen, Louise B. ; Kräker, Kristin ; Polemiti, Elli ; Jensen, Boye L. ; Jørgensen, Jan S. ; Dechend, Ralf ; Andersen, Marianne S.
Objective: Hypertension before and during early pregnancy has been associated with an increased risk of gestational diabetes mellitus (GDM) in retrospective analyses. We aimed to investigate the prospective blood pressure trackings in a population-based cohort of pregnant women, who were stratified according to their metabolic status in early third trimester. Methods: We recorded blood pressure longitudinally during pregnancy in 1230 women from the Odense Child Cohort, Denmark. Fasting glucose and insulin were measured at gestational weeks 28-30. Metabolic status was evaluated according to the WHO 2013 threshold for GDM (GDM-WHO: fasting plasma glucose >= 5.1 mmol/l), insulin and homeostatic model assessment of insulin resistance (HOMA-IR). Relationships between metabolic status in third trimester and blood pressure trajectories were evaluated with adjusted linear mixed models. Trajectory was defined as blood pressure records in pregnancy per 4 weeks interval. Results: Prevalence of GDM-WHO was 40% (498/1230). GDM-WHO was associated with 1.46 (0.22-2.70) mmHg higher SBP and 1.04 (0.07-2.01) mmHg higher DBP trajectories in the overall cohort. The associations were driven by differences in the overweight group, with 3.14 (1.05-5.25) mmHg higher SBP and 1.94 (0.42-3.47) mmHg higher DBP per 4 weeks in women with GDM-WHO compared with women without GDM-WHO. GDM-WHO was not associated with blood pressure in women with normal weight. Blood pressure trajectories were elevated across quartiles of insulin resistance. Conclusion: GDM-WHO is associated with higher blood pressure in pregnancy, and there appears to be a stronger effect in overweight women.
Mobile data collection of cognitive-behavioral tasks in substance use disorders: Where are we now?
(2022)
Zech, Hilmar G. ; Reichert, Markus ; Ebner-Priemer, Ulrich W. ; Tost, Heike ; Rapp, Michael A. ; Heinz, Andreas ; Dolan, Raymond J. ; Smolka, Michael N. ; Deserno, Lorenz
Introduction: Over the last decades, our understanding of the cognitive, motivational, and neural processes involved in addictive behavior has increased enormously. A plethora of laboratory-based and cross-sectional studies has linked cognitive-behavioral measures to between-subject differences in drinking behavior. However, such laboratory-based studies inevitably suffer from small sample sizes and the inability to link temporal fluctuations in task measures to fluctuations in real-life substance use. To overcome these problems, several existing behavioral tasks have been transferred to smartphones to allow studying cognition in the field. Method: In this narrative review, we first summarize studies that used existing behavioral tasks in the laboratory and self-reports of substance use with ecological momentary assessment (EMA) in the field. Next, we review studies on psychometric properties of smartphone-based behavioral tasks. Finally, we review studies that used both smartphone-based tasks and self-reports with EMA in the field. Results: Overall, studies were scarce and heterogenous both in tasks and in study outcomes. Nevertheless, existing findings are promising and point toward several methodological recommendations: concerning psychometrics, studies show that - although more systematic studies are necessary - task validity and reliability can be improved, for example, by analyzing several measurement sessions at once rather than analyzing sessions separately. Studies that use tasks in the field, moreover, show that power can be improved by choosing sampling schemes that combine time-based with event-based sampling, rather than relying on time-based sampling alone. Increasing sampling frequency can further increase power. However, as this also increases the burden to participants, more research is necessary to determine the ideal sampling frequency for each task. Conclusion: Although more research is necessary to systematically study both the psychometrics of smartphone-based tasks and the frequency at which task measures fluctuate, existing studies are promising and reveal important methodological recommendations useful for researchers interested in implementing behavioral tasks in EMA studies.
Ciarniello, Mauro ; Fulle, Marco ; Raponi, Andrea ; Filacchione, Gianrico ; Capaccioni, Fabrizio ; Rotundi, Alessandra ; Rinaldi, Giovanna ; Formisano, Michelangelo ; Magni, Gianfranco ; Tosi, Federico ; De Sanctis, Maria Cristina ; Capria, Maria Teresa ; Longobardo, Andrea ; Beck, Pierre ; Fornasier, Sonia ; Kappel, David ; Mennella, Vito ; Mottola, Stefano ; Rousseau, Batiste ; Arnold, Gabriele
Comets evolve due to sublimation of ices embedded inside porous dust, triggering dust emission (that is, erosion) followed by mass loss, mass redistribution and surface modifications. Surface changes were revealed by the Deep Impact and Stardust NExT missions for comet 9P/Tempel 1 (ref.(1)), and a full inventory of the processes modifying cometary nuclei was provided by Rosetta while it escorted comet 67P/Churyumov-Gerasimenko for approximately two years(2-4). Such observations also showed puzzling water-ice-rich spots that stood out as patches optically brighter and spectrally bluer than the average cometary surfaces(5-9). These are up to tens of metres large and indicate macroscopic compositional dishomogeneities apparently in contrast with the structural homogeneity above centimetre scales of pebble-made nuclei(10). Here we show that the occurrence of blue patches determines the seasonal variability of the nucleus colour(4,11,12) and gives insight into the internal structure of comets. We define a new model that links the centimetre-sized pebbles composing the nucleus(10) and driving cometary activity(13,14) to metre-sized water-ice-enriched blocks embedded in a drier matrix. The emergence of blue patches is due to the matrix erosion driven by CO2-ice sublimation that exposes the water-ice-enriched blocks, which in turn are eroded by water-ice sublimation when exposed to sunlight. Our model explains the observed seasonal evolution of the nucleus and reconciles the available data at micro (sub-centimetre) and macro (metre) scales.
Licht, Alexis ; Kelson, Julia ; Bergel, Shelly J. ; Schauer, Andrew J. ; Petersen, Sierra Victoria ; Capirala, Ashika ; Huntington, Katharine W. ; Dupont-Nivet, Guillaume ; Win, Zaw ; Aung, Day Wa
Pedogenic carbonate is widespread at mid latitudes where warm and dry conditions favor soil carbonate growth from spring to fall. The mechanisms and timing of pedogenic carbonate formation are more ambiguous in the tropical domain, where long periods of soil water saturation and high soil respiration enhance calcite dissolution. This paper provides stable carbon, oxygen and clumped isotope values from Quaternary and Miocene pedogenic carbonates in the tropical domain of Myanmar, in areas characterized by warm (>18°C) winters and annual rainfall up to 1,700 mm. We show that carbonate growth in Myanmar is delayed to the driest and coldest months of the year by sustained monsoonal rainfall from mid spring to late fall. The range of isotopic variability in Quaternary pedogenic carbonates can be solely explained by temporal changes of carbonate growth within the dry season, from winter to early spring. We propose that high soil moisture year-round in the tropical domain narrows carbonate growth to the driest months and makes it particularly sensitive to the seasonal distribution of rainfall. This sensitivity is also enabled by high winter temperatures, allowing carbonate growth to occur outside the warmest months of the year. This high sensitivity is expected to be more prominent in the geological record during times with higher temperatures and greater expansion of the tropical realm. Clumped isotope temperatures, δ13C and δ18O values of tropical pedogenic carbonates are impacted by changes of both rainfall seasonality and surface temperatures; this sensitivity can potentially be used to track past tropical rainfall distribution.
Van den Wyngaert, Silke ; Ganzert, Lars ; Seto, Kensuke ; Rojas-Jimenez, Keilor ; Agha, Ramsy ; Berger, Stella A. ; Woodhouse, Jason ; Padisak, Judit ; Wurzbacher, Christian ; Kagami, Maiko ; Grossart, Hans-Peter
Zoosporic fungi of the phylum Chytridiomycota (chytrids) regularly dominate pelagic fungal communities in freshwater and marine environments. Their lifestyles range from obligate parasites to saprophytes. Yet, linking the scarce available sequence data to specific ecological traits or their host ranges constitutes currently a major challenge. We combined 28 S rRNA gene amplicon sequencing with targeted isolation and sequencing approaches, along with cross-infection assays and analysis of chytrid infection prevalence to obtain new insights into chytrid diversity, ecology, and seasonal dynamics in a temperate lake. Parasitic phytoplankton-chytrid and saprotrophic pollen-chytrid interactions made up the majority of zoosporic fungal reads. We explicitly demonstrate the recurrent dominance of parasitic chytrids during frequent diatom blooms and saprotrophic chytrids during pollen rains. Distinct temporal dynamics of diatom-specific parasitic clades suggest mechanisms of coexistence based on niche differentiation and competitive strategies. The molecular and ecological information on chytrids generated in this study will aid further exploration of their spatial and temporal distribution patterns worldwide. To fully exploit the power of environmental sequencing for studies on chytrid ecology and evolution, we emphasize the need to intensify current isolation efforts of chytrids and integrate taxonomic and autecological data into long-term studies and experiments.
Stochastic resetting, a diffusive process whose amplitude is reset to the origin at random times, is a vividly studied strategy to optimize encounter dynamics, e.g., in chemical reactions. Here we generalize the resetting step by introducing a random resetting amplitude such that the diffusing particle may be only partially reset towards the trajectory origin or even overshoot the origin in a resetting step. We introduce different scenarios for the random-amplitude stochastic resetting process and discuss the resulting dynamics. Direct applications are geophysical layering (stratigraphy) and population dynamics or financial markets, as well as generic search processes.
Workplace friendships
(2023)
Workplace friendships, i.e., when work colleagues are also friends, are a widespread phenomenon in organizations which has attracted increasing research interest in recent decades. Numerous studies have investigated consequences of workplace friendships and found positive outcomes, such as increased employee job satisfaction or organizational performance, as well as negative outcomes, such as decreased knowledge-sharing between different friendship cliques. Other studies have examined what shapes workplace friendships, focusing on determinants such as personality or the spatial composition of organizations. Finally, an increasing number of studies focus on multiplex workplace friendships, where employees who are friends are also linked by a specific work-focused relationship. In this chapter, we first take stock of the literature on workplace friendships by providing an overview of their antecedents and consequences at the individual, the group, and the organizational level, and review the smaller body of research on multiplex workplace friendships. Second, we critically discuss practical implications of workplace friendships, focusing on their relevance to three current challenges for employees and organizations: the increase in virtual work, social inequalities in organizations, and the increased overlap of professional and private life. Finally, we provide recommendations for organizations on how to address these challenges and effectively manage workplace friendships.
In this paper, we study how the European Financial Reporting Advisory Group (EFRAG) used different legitimacy strategies between 2004 and 2021 to secure its organisational survival. Although EFRAG is now an established player within the regulatory space of corporate reporting, the organisation’s path towards this position was not straightforward. Based on 20 interviews with current and former members of EFRAG and archival documents, we investigate how EFRAG initially gained and maintained its legitimacy and how it responded to a legitimacy crisis arising in the aftermath of the 2008–2009 financial crisis. Based on prior research on organisational strategies for legitimising actions, we derive a framework for our analysis and show how EFRAG has adapted various legitimacy strategies over time. We further find that the use of legitimacy strategies is constrained by various systemic factors and show how EFRAG’s adaptations to its legitimacy strategies led to new tensions. Our findings contribute to the literature on private regulatory organisations’ legitimacy and the political economy of standard setting.
The Gutenberg-Richter (GR) and the Omori-Utsu (OU) law describe the earthquakes' energy release and temporal clustering and are thus of great importance for seismic hazard assessment. Motivated by experimental results, which indicate stress-dependent parameters, we consider a combined global data set of 127 main shock-aftershock sequences and perform a systematic study of the relationship between main shock-induced stress changes and associated seismicity patterns. For this purpose, we calculate space-dependent Coulomb Stress (& UDelta;CFS) and alternative receiver-independent stress metrics in the surrounding of the main shocks. Our results indicate a clear positive correlation between the GR b-value and the induced stress, contrasting expectations from laboratory experiments and suggesting a crucial role of structural heterogeneity and strength variations. Furthermore, we demonstrate that the aftershock productivity increases nonlinearly with stress, while the OU parameters c and p systematically decrease for increasing stress changes. Our partly unexpected findings can have an important impact on future estimations of the aftershock hazard.
The genus Microhyla Tschudi, 1838 includes 52 species and is one of the most diverse genera of the family Microhylidae, being the most species-rich taxon of the Asian subfamily Microhylinae. The recent, rapid description of numerous new species of Microhyla with complex phylogenetic relationships has made the taxonomy of the group especially challenging. Several recent phylogenetic studies suggested paraphyly of Microhyla with respect to Glyphoglossus Gunther, 1869, and revealed three major phylogenetic lineages of mid-Eocene origin within this assemblage. However, comprehensive works assessing morphological variation among and within these lineages are absent. In the present study we investigate the generic taxonomy of Microhyla-Glyphoglossus assemblage based on a new phylogeny including 57 species, comparative morphological analysis of skeletons from cleared-and-stained specimens for 23 species, and detailed descriptions of generalized osteology based on volume-rendered micro-CT scans for five speciesal-together representing all major lineages within the group. The results confirm three highly divergent and well-supported clades that correspond with external and osteological morphological characteristics, as well as respective geographic distribution. Accordingly, acknowledging ancient divergence between these lineages and their significant morphological differentiation, we propose to consider these three lineages as distinct genera: Microhyla sensu stricto, Glyphoglossus, and a newly described genus, Nanohyla gen. nov.
V-Edge
(2022)
Dressler, Falko ; Chiasserini, Carla Fabiana ; Fitzek, Frank H. P. ; Karl, Holger ; Cigno, Renato Lo ; Capone, Antonio ; Casetti, Claudio ; Malandrino, Francesco ; Mancuso, Vincenzo ; Klingler, Florian ; Rizzo, Gianluca
As we move from 5G to 6G, edge computing is one of the concepts that needs revisiting. Its core idea is still intriguing: Instead of sending all data and tasks from an end user's device to the cloud, possibly covering thousands of kilometers and introducing delays lower-bounded by propagation speed, edge servers deployed in close proximity to the user (e.g., at some base station) serve as proxy for the cloud. This is particularly interesting for upcoming machine-learning-based intelligent services, which require substantial computational and networking performance for continuous model training. However, this promising idea is hampered by the limited number of such edge servers. In this article, we discuss a way forward, namely the V-Edge concept. V-Edge helps bridge the gap between cloud, edge, and fog by virtualizing all available resources including the end users' devices and making these resources widely available. Thus, V-Edge acts as an enabler for novel microservices as well as cooperative computing solutions in next-generation networks. We introduce the general V-Edge architecture, and we characterize some of the key research challenges to overcome in order to enable wide-spread and intelligent edge services.
Allegory and the poetic self
(2022)
This book is the first collective examination of Late Medieval intimate first-person narratives that blurred the lines between author, narrator, and protagonist and usually feature personification allegory and courtly love tropes, creating an experimental new family of poetry. In this volume, contributors analyze why the allegorical first-person romance embedded itself in the vernacular literature of Western Europe and remained popular for more than two centuries. The editors identify and discuss three predominant forms within this family: debate poetry, dream allegories, and autobiographies. Contributors offer textual analyses of key works from late medieval German, French, Italian, and Iberian literature, with discussion of developments in England, as well. Allegory and the Poetic Self offers a sophisticated, theoretically current discussion of relevant literature. This exploration of medieval “I” narratives offers insights not just into the premodern period but also into Western literature’s subsequent traditions of self-analysis and identity crafting through storytelling.