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- Hasso Plattner Institute (8)
- Individual differences (8)
- Interactional Linguistics (8)
- Judaism (8)
- Klausurtagung (8)
- Kohlenstoff (8)
- Künstliche Intelligenz (8)
- Landsat (8)
- Landslide (8)
- Language (8)
- Last Glacial Maximum (8)
- Lepus europaeus (8)
- Management (8)
- Metabolism (8)
- Microtus arvalis (8)
- Modelling (8)
- Morphology (8)
- NICS (8)
- Netzwerke (8)
- Nichtlineare Dynamik (8)
- Optimization (8)
- Overweight (8)
- PUFA (8)
- Phytoplankton (8)
- Polymere (8)
- Prediction (8)
- Prevention (8)
- Pseudomonas aeruginosa (8)
- Quality of life (8)
- Randomized controlled trial (8)
- Security (8)
- Sentence comprehension (8)
- Service-oriented Systems Engineering (8)
- Spain (8)
- Sphingolipids (8)
- Sprachverarbeitung (8)
- Subduktion (8)
- Sun: filaments, prominences (8)
- Sustainability (8)
- Svalbard (8)
- Taxonomy (8)
- Tectonics (8)
- Theoretical calculations (8)
- Thermokarst (8)
- Through-space NMR shieldings (TSNMRS) (8)
- Transkriptionsfaktoren (8)
- Translation (8)
- Unsicherheit (8)
- Validation (8)
- Vitamin A (8)
- X-ray refraction (8)
- X-ray structure (8)
- Younger Dryas (8)
- Youth (8)
- Zooplankton (8)
- acceleration (8)
- acculturation (8)
- adolescent (8)
- alien species (8)
- animal movement (8)
- astrophysics (8)
- attitude (8)
- auxin (8)
- biofilm (8)
- biomineralization (8)
- block copolymer (8)
- carbon cycle (8)
- carbon dioxide (8)
- cardiovascular diseases (8)
- cells (8)
- charge transfer (8)
- chronic kidney disease (8)
- clefts (8)
- climate impacts (8)
- climate-change mitigation (8)
- consistency (8)
- convection (8)
- coronary artery disease (8)
- cortisol (8)
- cytotoxicity (8)
- data profiling (8)
- density functional calculations (8)
- diet (8)
- dissociative electron attachment (8)
- efficiency (8)
- electrospinning (8)
- energy policy (8)
- ensemble Kalman filter (8)
- executive functions (8)
- extension (8)
- extinction (8)
- flood (8)
- flow (8)
- fluorescence microscopy (8)
- force (8)
- forest management (8)
- fractional Brownian motion (8)
- frequency (8)
- galaxies (8)
- galaxies: dwarf (8)
- gamma-rays: galaxies (8)
- genetics (8)
- geochemistry (8)
- graphene (8)
- identity (8)
- imaging (8)
- immigration (8)
- immobilization (8)
- inclusion (8)
- inference (8)
- injury risk (8)
- instability (8)
- insurance (8)
- integration (8)
- intelligence (8)
- intergovernmental relations (8)
- international organizations (8)
- isomerization (8)
- isometric muscle action (8)
- land use change (8)
- landscape of fear (8)
- light (8)
- lipid metabolism (8)
- major depressive disorder (8)
- mathematical modeling (8)
- mathematische Modellierung (8)
- maximal isometric Adaptive Force (8)
- mechanisms (8)
- mechanobiology (8)
- membrane (8)
- membranes (8)
- microfluidics (8)
- microscopy (8)
- minerals (8)
- morphological processing (8)
- multicore architectures (8)
- nanocomposite (8)
- narcissism (8)
- natural language processing (8)
- natural products (8)
- neuromuscular control (8)
- neuroplasticity (8)
- neutron diffraction (8)
- noise (8)
- nuclear lamina (8)
- numerical relativity (8)
- numerical simulation (8)
- numerical simulations (8)
- oscillations (8)
- outflows (8)
- pain (8)
- parliamentary government (8)
- perceptual span (8)
- persistence (8)
- perturbation (8)
- phase transition (8)
- photoelectron spectroscopy (8)
- plankton (8)
- plant diversity (8)
- polarization (8)
- polyelectrolyte (8)
- pregnancy (8)
- productivity (8)
- pronouns (8)
- proteasome (8)
- pulsars: general (8)
- quality (8)
- quantification (8)
- quantum dots (8)
- quasars: general (8)
- reanalysis (8)
- rehabilitation (8)
- representation (8)
- reproducibility (8)
- research projects (8)
- residual stress (8)
- resources (8)
- restoration (8)
- risk perception (8)
- rotation (8)
- sedimentary ancient DNA (8)
- seismic hazard (8)
- sexual scripts (8)
- signal transduction (8)
- snow (8)
- social inclusion (8)
- spatial frequencies (8)
- stars: activity (8)
- stars: emission-line, Be (8)
- surface chemistry (8)
- surface modification (8)
- surveillance (8)
- suspended sediment (8)
- sustainable development (8)
- techniques: image processing (8)
- time-series (8)
- topography (8)
- treeline (8)
- trends (8)
- urbanization (8)
- variation (8)
- ventral striatum (8)
- visualization (8)
- vitamin A (8)
- water quality (8)
- youth sports (8)
- 20. Jahrhundert (7)
- 20th century (7)
- ADHD (7)
- Alps (7)
- Anisotropy (7)
- Anisotropy effect (7)
- Apoptosis (7)
- Aromaticity (7)
- Atmosphäre (7)
- BMI (7)
- COVID-19 pandemic (7)
- Capsella (7)
- Central Europe (7)
- Complex networks (7)
- Connectivity (7)
- Conversation Analysis (7)
- Crustal structure (7)
- Cytotoxicity (7)
- DNA radiation damage (7)
- Decision-making (7)
- Dirac operator (7)
- East African Rift System (7)
- Eutrophication (7)
- Fokus (7)
- GIS (7)
- Geochemistry (7)
- Geophysik (7)
- Global change (7)
- Hertzsprung-Russell and C-M diagrams (7)
- Higher education (7)
- Indian Summer Monsoon (7)
- Information Structure (7)
- Interoception (7)
- Japanese (7)
- K-theory (7)
- Klimaänderung (7)
- LCSM (7)
- Leguminosae (7)
- LiDAR (7)
- Longitudinal study (7)
- Magnetismus (7)
- Mekong Delta (7)
- Meta-analysis (7)
- Molecular dynamics (7)
- Molecularly imprinted polymers (7)
- Molybdenum cofactor (7)
- Monsoon (7)
- Monsun (7)
- Movement (7)
- Muscle strength (7)
- Namibia (7)
- Navier-Stokes equations (7)
- Norway (7)
- Nutrition (7)
- Palaeoclimate (7)
- Paläoklimatologie (7)
- Patterns (7)
- Pavlovian-to-instrumental transfer (7)
- Perception (7)
- Photosynthese (7)
- Phylogeography (7)
- Prevalence (7)
- Prosodie (7)
- Protein (7)
- RIXS (7)
- Raman (7)
- Remote sensing (7)
- Ring current effect (7)
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- Seesedimente (7)
- Soil (7)
- Soil erosion (7)
- Soil moisture (7)
- Solanaceae (7)
- Starch metabolism (7)
- Survey (7)
- Switzerland (7)
- TAVI (7)
- Theory (7)
- Tien Shan (7)
- Time series (7)
- Time series analysis (7)
- Tolkien (7)
- Uncertainty (7)
- United Nations (7)
- Unsicherheiten (7)
- Vesikel (7)
- Visualisierung (7)
- Vulnerabilität (7)
- Walking (7)
- Water quality (7)
- X-rays: ISM (7)
- Zinc (7)
- acquisition (7)
- admixture (7)
- aggregation (7)
- air pollution (7)
- allostatic load (7)
- amygdala (7)
- antioxidants (7)
- arctic (7)
- arithmetic (7)
- articulation (7)
- bicameralism (7)
- big data (7)
- binaries: eclipsing (7)
- birth weight (7)
- bystander (7)
- cAMP (7)
- calibration (7)
- catalogs (7)
- cell adhesion (7)
- change (7)
- charge generation (7)
- chemistry (7)
- chemotaxis (7)
- child (7)
- child development (7)
- circadian clock (7)
- circulation (7)
- circumstellar matter (7)
- cities (7)
- coastal erosion (7)
- coherence (7)
- community ecology (7)
- comparison (7)
- competence (7)
- complex systems (7)
- complexes (7)
- complexity (7)
- control (7)
- cyber aggression (7)
- defense (7)
- density (7)
- dietary patterns (7)
- discrepancy principle (7)
- distribution (7)
- duplicate detection (7)
- dust (7)
- ecological modelling (7)
- economy (7)
- ecosystem functioning (7)
- energy (7)
- energy storage (7)
- entropy (7)
- enzyme (7)
- enzyme catalysis (7)
- enzymes (7)
- experiments (7)
- extraction (7)
- extreme rainfall (7)
- fNIRS (7)
- first passage (7)
- first passage time (7)
- fluorescence correlation spectroscopy (7)
- food webs (7)
- function (7)
- functional magnetic resonance imaging (7)
- galaxies: abundances (7)
- gender differences (7)
- gene flow (7)
- geodynamics (7)
- giving-up density (7)
- globalization (7)
- grain size (7)
- habitat (7)
- heart (7)
- heart rate variability (7)
- heterogeneous catalysis (7)
- holocene (7)
- home range (7)
- human impact (7)
- imaging spectroscopy (7)
- infrared: stars (7)
- insect (7)
- institutions (7)
- insula (7)
- interoceptive awareness (7)
- isotopes (7)
- jumping (7)
- kinematics (7)
- land-use change (7)
- last glacial maximum (7)
- life history (7)
- low-energy electrons (7)
- magnetism (7)
- malnutrition (7)
- manifolds with singularities (7)
- mapping (7)
- measurement (7)
- memory retrieval (7)
- metaanalysis (7)
- metabolic networks (7)
- metabolite profiling (7)
- methane (7)
- microbial ecology (7)
- microtubules (7)
- modality (7)
- modern Jewish history (7)
- molecular modeling (7)
- multilingualism (7)
- muscle (7)
- nonergodicity (7)
- nuclear envelope (7)
- organic matter (7)
- organic photovoltaics (7)
- orthography (7)
- overweight (7)
- oxygen (7)
- pH (7)
- palaeoclimate (7)
- palaeoecology (7)
- paleoecology (7)
- pandemic (7)
- parafoveal processing (7)
- parameter estimation (7)
- pathogens (7)
- phase transitions (7)
- planetary nebulae: general (7)
- planets and satellites: rings (7)
- pollution (7)
- porous materials (7)
- predator-prey dynamics (7)
- presidential government (7)
- production control (7)
- programming (7)
- pronoun resolution (7)
- propensity score matching (7)
- prosodic boundary cues (7)
- pseudodifferential operators (7)
- public management (7)
- radiocarbon (7)
- recombination (7)
- reconstruction (7)
- reflection (7)
- repair (7)
- reproduction (7)
- retinol (7)
- rheology (7)
- roughness (7)
- scattering (7)
- secular trend (7)
- sediment transport (7)
- seismicity (7)
- selenium (7)
- self-concept (7)
- self-regulation (7)
- sensors (7)
- shape-memory effect (7)
- sharing economy (7)
- silicon (7)
- silver nanoparticles (7)
- size (7)
- social rejection (7)
- soil organic carbon (7)
- solar wind (7)
- sorption (7)
- speciation (7)
- speed (7)
- stabile Isotope (7)
- standardization (7)
- stars: late-type (7)
- sunspots (7)
- support vector machine (7)
- surfactants (7)
- surgery (7)
- tVNS (7)
- teaching (7)
- thermokarst (7)
- tomography (7)
- traits (7)
- transcriptome (7)
- transfer (7)
- transition (7)
- trunk (7)
- ultrafast dynamics (7)
- uncertainty analysis (7)
- verification (7)
- water management (7)
- weather (7)
- wh-in-situ (7)
- wh-questions (7)
- working memory capacity (7)
- yellow flags (7)
- AFM (6)
- Adipositas (6)
- Ageing (6)
- Agency (6)
- Alaska (6)
- Antibiotikaresistenz (6)
- Aphasie (6)
- Arbeitsgedächtnis (6)
- Arsenolipids (6)
- Assessment (6)
- Bakterien (6)
- Balance (6)
- Bayesian data analysis (6)
- Bewegungsökologie (6)
- Big Five (6)
- Bioelectrocatalysis (6)
- Biofilm (6)
- Biogenic amine (6)
- Biophysik (6)
- Blockcopolymere (6)
- Bodenfeuchte (6)
- C-reactive protein (6)
- CO2 (6)
- Caribbean (6)
- Chytridiomycota (6)
- Click chemistry (6)
- Colombia (6)
- Computational modelling (6)
- Coping (6)
- Copper (6)
- Cystic fibrosis (6)
- Data assimilation (6)
- Datenbank (6)
- Deep learning (6)
- Design (6)
- Dezentralisierung (6)
- Digitalisierung (6)
- Disturbance (6)
- Diversity (6)
- Dynamic NMR (6)
- EEG/ERP (6)
- Earthquake dynamics (6)
- Earthquake hazards (6)
- Electrical conductivity (6)
- Emotions (6)
- Energy (6)
- Europa (6)
- European hare (6)
- Facebook (6)
- Flood (6)
- Flood risk (6)
- Fluorescence spectroscopy (6)
- Gammastrahlungsastronomie (6)
- Gene-environment interaction (6)
- Genomics (6)
- Geomagnetism (6)
- Geomorphology (6)
- Governance (6)
- Groundwater (6)
- H II regions (6)
- HIREC (6)
- Hodge theory (6)
- ISM: kinematics and dynamics (6)
- Immunoassay (6)
- Induced seismicity (6)
- Insurance (6)
- Interaction (6)
- Interest (6)
- Japan (6)
- Kant (6)
- Lake Van (6)
- Lakes (6)
- Land use change (6)
- Language acquisition (6)
- Lasers (6)
- Late Pleistocene (6)
- Levy flights (6)
- Local Group (6)
- Longitudinal (6)
- Lysiphlebus fabarum (6)
- Magnetohydrodynamik (6)
- Mandarin Chinese (6)
- Massenspektrometrie (6)
- Measurement (6)
- Mediterranean (6)
- Mental arithmetic (6)
- Methane (6)
- Microcystis aeruginosa (6)
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- Middle East (6)
- Mobility (6)
- Modell (6)
- Monitoring (6)
- Mortality (6)
- Movement ecology (6)
- NASH (6)
- NE81 (6)
- Nachhaltigkeit (6)
- Nanostruktur (6)
- Neotektonik (6)
- Neumann problem (6)
- Neural networks (6)
- Neuroenhancement (6)
- Neurotoxicity (6)
- Nutrients (6)
- O-antigen (6)
- Oxygen heterocycles (6)
- PBPK (6)
- Paleolimnology (6)
- Perceptual span (6)
- Phase transitions (6)
- Phenotypic plasticity (6)
- Phonons (6)
- Poecilia mexicana (6)
- Polyelektrolyte (6)
- Polymerchemie (6)
- Polymers (6)
- Population genetics (6)
- Predictors (6)
- Prenatal stress (6)
- Priming (6)
- Prozessmodellierung (6)
- Prunus avium L. (6)
- Pseudo-differential operators (6)
- Pyrenees (6)
- Quasare (6)
- R&D (6)
- Reinforcement learning (6)
- Reliability (6)
- Resistance training (6)
- Return to work (6)
- Rheologie (6)
- Rheology (6)
- SARS-CoV-2 (6)
- SDS-PAGE (6)
- SWIM (6)
- Saturn (6)
- Schadensmodellierung (6)
- Second World War (6)
- Sediment (6)
- Seismic tomography (6)
- Self-paced reading (6)
- Sentinel-1 (6)
- Sexual scripts (6)
- Sexual selection (6)
- Smalltalk (6)
- Solanum lycopersicum (6)
- Speech perception (6)
- Sphingosine 1-phosphate (6)
- Stable isotopes (6)
- Sternentwicklung (6)
- Stretch-shortening cycle (6)
- Subduction zone processes (6)
- Synthesis (6)
- TMS (6)
- TRMM (6)
- Temperature (6)
- Theoretical seismology (6)
- Thermochronologie (6)
- Time reference (6)
- Toeplitz operators (6)
- Topic (6)
- Topography (6)
- Toxicity (6)
- Transformation (6)
- Twitter (6)
- Unsicherheitsanalyse (6)
- Variability (6)
- Vegetation (6)
- Vietnam (6)
- Vietnamese (6)
- Water (6)
- West Bohemia (6)
- Westerlies (6)
- Wind erosion (6)
- acid ceramidase (6)
- administration (6)
- age of acquisition (6)
- agreement (6)
- alexithymia (6)
- algorithms (6)
- alignment (6)
- amino acids (6)
- anger (6)
- animacy (6)
- anthropometry (6)
- antibody (6)
- apoptosis (6)
- arenes (6)
- attitudes (6)
- bias (6)
- biodegradable polymers (6)
- biomimetic sensors (6)
- biosensors (6)
- black holes (6)
- blockchain (6)
- brain (6)
- bryophytes (6)
- business processes (6)
- capacity (6)
- cardiorespiratory fitness (6)
- cartel (6)
- cell-free protein synthesis (6)
- change detection (6)
- characteristics (6)
- chemical modification (6)
- chloroplast (6)
- co-limitation (6)
- collaboration (6)
- collusion (6)
- colonialism (6)
- community effect (6)
- composition (6)
- computed tomography (6)
- computer vision (6)
- constraints (6)
- context (6)
- contrast (6)
- conversation analysis (6)
- corruption (6)
- costs (6)
- crisis management (6)
- crown compounds (6)
- crystal-structure (6)
- cyber victimization (6)
- cyber-physical systems (6)
- cystic fibrosis (6)
- cytoskeleton (6)
- data (6)
- databases (6)
- decarbonization (6)
- depressive symptoms (6)
- diabetic nephropathy (6)
- dielectrophoresis (6)
- diffuse radiation (6)
- digital (6)
- domestication (6)
- dopamine (6)
- droughts (6)
- dust, extinction (6)
- dynamic (6)
- dyslexia (6)
- early warning (6)
- eclogite (6)
- ecohydrology (6)
- economics (6)
- effectiveness (6)
- efficient (6)
- eicosapentaenoic acid (6)
- electrons (6)
- electrostatic interactions (6)
- elementary particles (6)
- energy efficiency (6)
- engagement (6)
- english (6)
- entrepreneurship education (6)
- environmental change (6)
- exercise therapy (6)
- eye movement (6)
- fabrication (6)
- facilitation (6)
- feedback (6)
- fertilization (6)
- first-passage time (6)
- floodplain (6)
- formal semantics (6)
- fragmentation (6)
- galaxy evolution (6)
- gamma-ray astronomy (6)
- gamma-rays: general (6)
- gas (6)
- gelatin (6)
- general relativity (6)
- genes (6)
- geology (6)
- geometric Brownian motion (6)
- givenness (6)
- glacier (6)
- global (6)
- global warming (6)
- grammar (6)
- gravity (6)
- groundwater (6)
- habituation (6)
- herbivory (6)
- heterocycles (6)
- high pressure (6)
- history and philosophy of astronomy (6)
- holding capacity (6)
- hybridization capture (6)
- hydrolysis (6)
- impacts (6)
- infancy (6)
- infection (6)
- injury (6)
- institutional change (6)
- interfaces (6)
- introgression (6)
- invasive species (6)
- knowledge transfer (6)
- kosmische Strahlung (6)
- künstliche Intelligenz (6)
- leadership (6)
- lifespan (6)
- linagliptin (6)
- lithosphere (6)
- locus of control (6)
- macrophytes (6)
- magnetic nanoparticles (6)
- massive stars (6)
- maturation (6)
- meaning (6)
- mechanism (6)
- media violence (6)
- melt inclusions (6)
- mental simulation (6)
- metabolites (6)
- methods: analytical (6)
- miRNA (6)
- micelles (6)
- microbial communities (6)
- microbial diversity (6)
- mind wandering (6)
- molecular motors (6)
- moment tensor (6)
- muscle power (6)
- neotectonics (6)
- network analysis (6)
- neurodegeneration (6)
- next generation sequencing (6)
- non-fullerene acceptors (6)
- nucleation (6)
- nucleus (6)
- numerical development (6)
- organization (6)
- p53 (6)
- parameters (6)
- participation (6)
- pattern formation (6)
- perovskite (6)
- phenology (6)
- phonetics (6)
- phosphate (6)
- phylogenetic diversity (6)
- piezoelectricity (6)
- plant (6)
- plants (6)
- plasma membrane (6)
- plyometric training (6)
- political equality (6)
- politics (6)
- polyelectrolytes (6)
- polystyrene (6)
- polyzwitterions (6)
- population density (6)
- porosity (6)
- porous carbon (6)
- postural stability (6)
- presupposition (6)
- probiotics (6)
- process mining (6)
- projections (6)
- prosocial behavior (6)
- protection (6)
- protein-protein interaction (6)
- racism (6)
- radical polymerization (6)
- rainfall (6)
- rat (6)
- reciprocal class (6)
- reduction (6)
- relative index (6)
- religion (6)
- retinol-binding protein 4 (6)
- risk factor (6)
- running (6)
- saccades (6)
- salinity gradient (6)
- salivary gland (6)
- salt stress (6)
- savanna (6)
- scale development (6)
- scrambling (6)
- sedaDNA (6)
- seismic tomography (6)
- self-healing (6)
- sensitivity analysis (6)
- sensor (6)
- sentence production (6)
- soccer (6)
- social capital (6)
- social comparison (6)
- socioeconomic status (6)
- sodium (6)
- software engineering (6)
- spectra (6)
- star formation (6)
- stars: horizontal-branch (6)
- stars: magnetic fields (6)
- stellar evolution (6)
- stimuli-sensitive polymers (6)
- stochastic differential equations (6)
- stroke (6)
- sucrose (6)
- sulfite oxidase (6)
- teacher education (6)
- thaliana (6)
- therapist competence (6)
- thermoresponsive polymers (6)
- tomato (6)
- tools (6)
- tracking (6)
- trade-offs (6)
- training adaptation (6)
- transcriptional memory (6)
- tundra (6)
- uncertainty quantification (6)
- unemployment (6)
- uplift (6)
- user experience (6)
- validation study (6)
- video analysis (6)
- violence (6)
- visions of democracy (6)
- visual attention (6)
- walking (6)
- water balance (6)
- water resources (6)
- weight loss (6)
- wetlands (6)
- women (6)
- words (6)
- world literature (6)
- zebrafish (6)
- 19. Jahrhundert (5)
- 3D point clouds (5)
- 3D visualization (5)
- AC electrokinetics (5)
- ALAN (5)
- ARPES (5)
- Absorption (5)
- Ackerschmalwand (5)
- Adolescent (5)
- African Humid Period (5)
- Afrika (5)
- Aftercare (5)
- Age of acquisition (5)
- Air pollution (5)
- Algeria (5)
- Alterung (5)
- Amygdala (5)
- Ancient DNA (5)
- Animal personality (5)
- Antwortmengenprogrammierung (5)
- Arctic lakes (5)
- Arrayseismologie (5)
- Arsenic-containing hydrocarbons (5)
- Artificial Intelligence (5)
- Asian monsoon (5)
- Asteraceae (5)
- Atiyah-Patodi-Singer theory (5)
- Aufmerksamkeit (5)
- Australien (5)
- Autocorrelation (5)
- Basketball (5)
- Bayesian inversion (5)
- Bayesian networks (5)
- Bilingualism (5)
- Biodiversity Exploratories (5)
- Biodiversity exploratories (5)
- Bioinformatik (5)
- Biosensors (5)
- Black Sea (5)
- Block copolymers (5)
- Blockcopolymer (5)
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- shape (4)
- shape memory (4)
- shape-memory polymers (4)
- shrub encroachment (4)
- signal propagation (4)
- similarity measures (4)
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- wetting (4)
- wh-movement (4)
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- Spatial cognition (3)
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- Species comparison (3)
- Speed (3)
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- Sphingosine kinase (3)
- Split-belt treadmill (3)
- Sprache (3)
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- Squeak (3)
- Stage-based model (3)
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- Surprisal (3)
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- Systematics (3)
- TD-DFT (3)
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- TTR (3)
- Tagalog acquisition (3)
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- TanDEM-X (3)
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- Tanzania (3)
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- Tibet (3)
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- Tools (3)
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- Tracking (3)
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- Transfer (3)
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- Transport (3)
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- Two forms of isometric muscle action (3)
- Type 1 diabetes (3)
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- Understanding (3)
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- [4+2] cycloaddition (3)
- ab initio (3)
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- abstraction (3)
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- acceptability judgments (3)
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- adulthood (3)
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- aging brain (3)
- aid effectiveness (3)
- albuminuria (3)
- allocation policies (3)
- alteration geochemistry (3)
- ambient noise (3)
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- amperometry (3)
- analytics (3)
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- annotation (3)
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- arable land (3)
- area (3)
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- aspect (3)
- aspect ratio (3)
- assemblies (3)
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- asymmetry (3)
- asymptotic behavior (3)
- asymptotic expansion (3)
- athlete (3)
- atmospheric deposition (3)
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- atomic force microscopy (AFM) (3)
- attentional demand (3)
- attenuation tomography (3)
- attraction (3)
- auditory perception (3)
- authentication (3)
- authenticity (3)
- authoritarianism (3)
- authority (3)
- autism (3)
- automatic processing (3)
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- auxotrophy (3)
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- bandgap (3)
- basal accretion (3)
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- bat fatalities (3)
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- calculation (3)
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- cartographic design (3)
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- catalogues (3)
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- cis-regulatory evolution (3)
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- clay (3)
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- coatings (3)
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- code generation (3)
- coercion (3)
- coercive strategies (3)
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- cohomology (3)
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- collective dynamics (3)
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- collective team identification (3)
- college students (3)
- comets: individual: 67P/Churyumov-Gerasimenko (3)
- community assembly (3)
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- compensatory dynamics (3)
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- complementarity (3)
- complex (3)
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- conservation laws (3)
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- constraint-based modeling (3)
- consumption (3)
- consumptive resistance (3)
- contact (3)
- content areas (3)
- continental lithosphere (3)
- continuous time random walk (3)
- contrastive focus (3)
- controlled radical polymerization (3)
- coping (3)
- coping styles (3)
- coronal mass ejections (CMEs) (3)
- coronary bypass grafting (3)
- corpus analysis (3)
- correlated noise (3)
- cosmology (3)
- cost-benefit analysis (3)
- cost-effectiveness (3)
- counterterrorism (3)
- counting process (3)
- coupled oscillators (3)
- coupled rotators (3)
- coupling (3)
- course design (3)
- critical avalanche dynamics (3)
- critical phenomena (3)
- crop (3)
- cross-curriculum (3)
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- crowding (3)
- crowdsourcing (3)
- crust (3)
- cryolithology (3)
- cryptic species (3)
- crystalline (3)
- cue validity (3)
- cultural conceptualisations (3)
- cultural conceptualizations (3)
- cultural identity (3)
- curvature (3)
- cybervictimization (3)
- cycloaddition (3)
- cylindrical geometry (3)
- cytosolic tRNA thiolation (3)
- damage estimation (3)
- damage modeling (3)
- dark ages (3)
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- dark triad (3)
- data fusion (3)
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- database systems (3)
- de Rham complex (3)
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- decision tree (3)
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- deduplication (3)
- deep convection (3)
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- defense against predation (3)
- definition (3)
- degraded DNA (3)
- dehydration (3)
- delta-D values (3)
- democratic theory (3)
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- dendroclimatology (3)
- denitrification (3)
- density functional theory (3)
- denudation (3)
- dependency (3)
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- desiccation (3)
- design parameters (3)
- detection (3)
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- diagnostics (3)
- dialect (3)
- diamond anvil cell (3)
- dielectric relaxation spectroscopy (3)
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- differential gene expression (3)
- diffraction (3)
- diffusing diffusivity (3)
- digital elevation model (3)
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- discharge (3)
- discourse analysis (3)
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- eco-evolutionary feedbacks (3)
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- ecological stoichiometry (3)
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- elastic properties (3)
- elastomers (3)
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- electron dynamics (3)
- electrophysiological evidence (3)
- elemental composition (3)
- elevated plus-maze (3)
- elite athlete (3)
- ellipsometry (3)
- embedded systems (3)
- emergency management (3)
- emotional intelligence (3)
- emotional valence (3)
- employment services (3)
- empowerment (3)
- encoding (3)
- end-stage kidney disease (3)
- endoperoxides (3)
- endothelial cells (3)
- endothelin (3)
- endothelin-converting enzyme (3)
- endozoochory (3)
- endurance exercise (3)
- energy transfer (3)
- energy transition (3)
- energy-metabolism (3)
- enjoyment (3)
- ensemble prediction (3)
- enterprise systems (3)
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- envy (3)
- enzyme immobilization (3)
- enzymology (3)
- ephrin (3)
- episodic memory (3)
- epistemic modality (3)
- epizoochory (3)
- equality (3)
- equalizing and stabilizing mechanisms (3)
- equation (3)
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- equatorial ionosphere (3)
- equi-singular connections (3)
- erythropoiesis (3)
- escherichia-coli (3)
- establishment (3)
- estimation (3)
- eta invariant (3)
- ethnic differences (3)
- ethnic identity (3)
- ethnic-racial identity (3)
- evaluative priming (3)
- evaporation (3)
- event (3)
- event-related potentials (ERP) (3)
- eventology (3)
- everyday life (3)
- evidence (3)
- evolution equation (3)
- exchange (3)
- executive personalism (3)
- exercise adherence (3)
- exercise training (3)
- expansion microscopy (3)
- experience (3)
- experimental linguistics (3)
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- exploitation (3)
- exploration (3)
- explosives (3)
- extracellular matrix (3)
- extraction and characterization methods (3)
- extremes (3)
- eye-movements (3)
- eye-voice span (3)
- face morphing (3)
- facial feedback (3)
- factor analysis (3)
- factor structure (3)
- failure (3)
- faking (3)
- fault reactivation (3)
- feminism (3)
- fermentation (3)
- fermentation-related enzymes (3)
- ferroelectrets (3)
- fibers (3)
- fibrosis (3)
- field test (3)
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- fieldwork (3)
- figurative language (3)
- film (3)
- filter (3)
- financial time series (3)
- finite element modeling (3)
- first stars (3)
- first-hitting time (3)
- fiscal policy (3)
- fitness consequences (3)
- fixation locations (3)
- flavonoid (3)
- flavonoids (3)
- flood hazard (3)
- flood hazards (3)
- flood loss (3)
- flood risk analysis (3)
- floodplain sedimentation (3)
- floodplains (3)
- flowering (3)
- fluctuation-dissipation theorem (3)
- fluid flow (3)
- fluid-rock interaction (3)
- fluorescence lifetime (3)
- flux (3)
- foam (3)
- focus constructions (3)
- focus movement (3)
- food neophilia (3)
- food security (3)
- foreign policy (3)
- forest structure (3)
- forestREplot (3)
- formal languages (3)
- formale Verifikation (3)
- formate dehydrogenase (3)
- formation damage (3)
- frailty (3)
- framework (3)
- frameworks (3)
- freedom (3)
- freedom restriction (3)
- fricative (3)
- functional (3)
- functional capacity (3)
- functional dependencies (3)
- functional dependency (3)
- functional near-infrared spectroscopy (3)
- functionalization (3)
- fungal diversity (3)
- fuzzy logic (3)
- gait analysis (3)
- galaxies: individual: LMC (3)
- galaxies: magnetic fields (3)
- galaxy structure (3)
- gallbladder cancer (3)
- games (3)
- garnet (3)
- gas adsorption (3)
- gels (3)
- gender gap (3)
- gender inequality (3)
- gender pay gap (3)
- gender wage gap (3)
- gene duplication (3)
- gene family (3)
- gene regulatory network (3)
- generalizability (3)
- generalization (3)
- genetic programming (3)
- genome assembly (3)
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- genotype (3)
- geometry (3)
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- geostatistics (3)
- geothermal (3)
- gesture (3)
- glacial erosion (3)
- glacial hazards (3)
- glacial lake outburst floods (3)
- glacial refugia (3)
- glass (3)
- global environmental change (3)
- global monsoon (3)
- global surface warming (3)
- globular clusters: individual: NGC 6397 (3)
- glucan (3)
- glucocorticoid receptor (3)
- glycaemic control (3)
- glycogen (3)
- glycopolymers (3)
- goal frames (3)
- goblet cells (3)
- good governance (3)
- government (3)
- gradient boosting (3)
- gradient flow (3)
- grain-size distribution (3)
- grammatical illusion (3)
- granite (3)
- granitoids (3)
- graph (3)
- graph constraints (3)
- graphite (3)
- graphomotor control (3)
- grassland (3)
- grasslands (3)
- green (3)
- green growth (3)
- green-green dilemma (3)
- grief (3)
- gross primary production (3)
- ground reaction forces (3)
- grouping (3)
- growth rate (3)
- guilt (3)
- habit formation (3)
- habitat loss (3)
- habitat selection (3)
- hand (3)
- hantavirus (3)
- hard core potential (3)
- hazards (3)
- health behavior (3)
- health policy (3)
- heart rate (3)
- heat flow (3)
- heat stress memory (3)
- heath potentials (3)
- hemoglobin (3)
- heritage speakers (3)
- heterogene Katalyse (3)
- heterogene Photokatalyse (3)
- heterogeneous photocatalysis (3)
- hierarchical clustering (3)
- high temperature (3)
- high-pressure (3)
- high-resolution record (3)
- high-sodium (3)
- hillslopes (3)
- hip (3)
- historical DNA (3)
- honey bees (3)
- honeybee (3)
- hormones (3)
- hospitalization (3)
- hostile attribution bias (3)
- housing (3)
- hoverflies (3)
- human activity recognition (3)
- human evolution (3)
- human-robot interaction (3)
- hybrid model (3)
- hydraulic fracturing (3)
- hydrogen bonds (3)
- hydrogenation (3)
- hydrogeology (3)
- hydrological processes (3)
- hyperbolic tilings (3)
- hypersound (3)
- hyporheische Zone (3)
- hypothesis (3)
- hypoxia (3)
- iCheck (3)
- ice (3)
- ice sheet (3)
- identity management (3)
- ideology (3)
- ill-posed problem (3)
- image-based representation (3)
- imidazolium (3)
- imitation (3)
- impact assessment (3)
- impairment (3)
- impedance spectroscopy (3)
- implementation (3)
- implicit association test (IAT) (3)
- implicit learning (3)
- in-service teacher training (3)
- inbreeding depression (3)
- incision (3)
- incremental graph pattern matching (3)
- index of elliptic operators in subspaces (3)
- indirect facilitation (3)
- indirect tests (3)
- individual anaerobic threshold (3)
- individuelle Unterschiede (3)
- induced pluripotent stem cells (3)
- industry 4.0 (3)
- infant (3)
- inferences (3)
- infiltration (3)
- inflammatory bowel disease (3)
- inflectional morphology (3)
- information and communication technologies (3)
- information integration (3)
- infrared: diffuse background (3)
- infrastructure (3)
- injection (3)
- injury prevention (3)
- inner magnetosphere (3)
- input frequency (3)
- insects (3)
- institutional interplay (3)
- instrumental variables (3)
- instrumentation (3)
- intensification (3)
- intentional forgetting (3)
- intercultural competence (3)
- interface engineering (3)
- interfacial recombination (3)
- interferometry (3)
- intergalaktisches Medium (3)
- interindividual differences (3)
- interleukin-8 (3)
- intermediate disturbance hypothesis (3)
- international (3)
- international bureaucracies (3)
- international comparison (3)
- international migration (3)
- intervention locality (3)
- intonation (3)
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- intracellular-transport (3)
- intraclass correlation (3)
- intraspecific variation (3)
- intrinsically disordered proteins (3)
- invasion (3)
- inverse ill-posed problem (3)
- inverse micelles (3)
- inverse theory (3)
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- ionothermal synthesis (3)
- irrigation (3)
- islands (3)
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- isotopic composition (3)
- isotopic tiling theory (3)
- iterative regularization (3)
- job creation (3)
- job demands-resources model (3)
- job search (3)
- just transition (3)
- kana (3)
- kanji (3)
- kernel density estimation (3)
- kettle hole (3)
- kidney (3)
- kinetic instabilities (3)
- knowledge sharing (3)
- kognitive Modellierung (3)
- komplexe Systeme (3)
- komplexes Netzwerk (3)
- körperliche Fitness (3)
- l-cysteine desulfurase (3)
- labor supply (3)
- lactate threshold (3)
- lake monitoring (3)
- land cover change (3)
- land management (3)
- land-use (3)
- landing positions (3)
- landscape diversity (3)
- landscape homogenization (3)
- langevin equation (3)
- language comprehension (3)
- language courses (3)
- language proficiency (3)
- languages (3)
- larch (3)
- large-scale (3)
- last glacial period (3)
- late Holocene (3)
- late childhood (3)
- latitude (3)
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- leaf senescence (3)
- leaking (3)
- learning and memory (3)
- learning factories (3)
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- life course (3)
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- lifetime (3)
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- limits (3)
- line: profiles (3)
- linear mixed model (3)
- linear programming (3)
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- linked employer-employee data (3)
- lipid (3)
- liquid-phase catalysis (3)
- literacy acquisition (3)
- literatures of the world (3)
- lithium-sulfur batteries (3)
- load (3)
- logarithmic source condition (3)
- logic (3)
- logic programming (3)
- lokale Anpassung (3)
- longevity (3)
- losses (3)
- lower (3)
- lower thermosphere (3)
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- monomers (3)
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- poly(A) polymerase (3)
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- ) (2)
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- 1 (2)
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- 1D (2)
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- 35B09 (2)
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- 78A46 (2)
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- Meiosis (2)
- Melampyrum pratense (2)
- Mellin symbols with values in the edge calculus (2)
- Melt inclusions (2)
- Membran (2)
- Membranproteine (2)
- Menarche (2)
- Mensch-Computer-Interaktion (2)
- Mental disorder (2)
- Mercuric mercury (2)
- Mercury (2)
- Meromorphic operator-valued symbols (2)
- Mesenchymal stem cells (2)
- Mesokristalle (2)
- Mesoporous silicon (2)
- Mesozoic (2)
- Meta-Kommunikation (2)
- Metaanalysis (2)
- Metabarcoding (2)
- Metabolismus (2)
- Metabolite (2)
- Metaboliten (2)
- Metabolites (2)
- Metabolom (2)
- Metabolome analysis (2)
- Metacognition (2)
- Metacommunity (2)
- Metadata Discovery (2)
- Metadaten (2)
- Metagemeinschaften (2)
- Metal Metabolism (2)
- Metal complexation (2)
- Metal oxides (2)
- Metall (2)
- Metamaterials (2)
- Metanome (2)
- Metaphor (2)
- Metasprache (2)
- Metaverse (2)
- Meteorites (2)
- Meteorologie (2)
- Methan (2)
- Methanogenic archaea (2)
- Methode (2)
- Metschnikowia (2)
- MiSpEx Network (2)
- MiSpEx-network (2)
- Mice (2)
- Micelle (2)
- Michael addition (2)
- Michelin star (2)
- Micro-XRF (2)
- Microarray (2)
- Microarrays (2)
- Microbial abundance (2)
- Microbial community (2)
- Microbial ecology (2)
- Microbiome (2)
- Microcebus berthae (2)
- Microemulsion (2)
- Microlensing (2)
- Microorganisms (2)
- Microperoxidase-11 (2)
- Micropollutants (2)
- Microsaccade (2)
- Microsatellite analysis (2)
- Microscopy (2)
- Microstructure (2)
- Microvascular blood filling (2)
- Microwave chemistry (2)
- Middle Eocene deformation (2)
- Middle Strand (2)
- Mikroalgen (2)
- Mikrokredite (2)
- Mikrolinsen (2)
- Mikrosatelliten (2)
- Mikrotubuli (2)
- Mikroökonometrie (2)
- Milchstraße (2)
- Mild cognitive impairment (2)
- Milium effusum (2)
- Milky Way (2)
- Milky Way evolution (2)
- Mimicry (2)
- Mindestlohn (2)
- Minerals (2)
- Minimalist Program (2)
- Minimalist program (2)
- Minimax convergence rates (2)
- Minimum Wage (2)
- Ministerial bureaucracy (2)
- Ministerialverwaltung (2)
- Miozän (2)
- Mirror Principle (2)
- Missions (2)
- Mitogenomes (2)
- Mitosis (2)
- Mittag-Leffler function (2)
- Mittelmeerraum (2)
- Mixed mating (2)
- Mixotrophy (2)
- Mixtures (2)
- Mizelle (2)
- Mizellen (2)
- MoVo (2)
- Moa (2)
- Mobile Health (2)
- Mobile devices (2)
- Mobile diagnostics (2)
- Mobile learning (2)
- Modality (2)
- Mode function (2)
- Model Synchronization (2)
- Model calibration (2)
- Model checking (2)
- Model order reduction (2)
- Model transformation (2)
- Model-data comparison (2)
- Modellprüfung (2)
- Moderation (2)
- Modern analogue technique (2)
- Mojave toxin (2)
- Molasse Basin (2)
- Molecular orientation (2)
- Molekularer Motor (2)
- Molybdopterin (2)
- Moment tensor inversion (2)
- Momententensoren (2)
- Monetary Fund (2)
- Monolayer (2)
- Monoschicht (2)
- Mont Terri (2)
- Mood (2)
- Moon (2)
- Mormyrid Fish (2)
- Morocco (2)
- Morphemes (2)
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- Morphological structure (2)
- Morphometry (2)
- Morse-Smale property (2)
- Mortalität (2)
- Mother-infant interaction (2)
- Mountain basins (2)
- Mountain building (2)
- Mouse (2)
- Mowing (2)
- Mozambique (2)
- MtDNA (2)
- Multi-locus phylogeny (2)
- Multi-method (2)
- Multiblock copolymer (2)
- Multilayer (2)
- Multilayers (2)
- Multilevel latent change model (2)
- Multilevel modeling (2)
- Multilingualism (2)
- Multimodal analysis (2)
- Multimodality (2)
- Multiple Spell-Out (2)
- Multiple sclerosis (2)
- Multiple zeta values (2)
- Multivariate Analyse (2)
- Multivariate data analysis (2)
- Muntjac (2)
- Muscle mass (2)
- Muscle power (2)
- Muscle twitch (2)
- Musculoskeletal and neural physiological phenomena (2)
- Musculoskeletal injury (2)
- Museum collections (2)
- Music (2)
- Mustererkennung (2)
- MutMap (2)
- Mutation rate (2)
- Mutator locus (2)
- Myelosuppression (2)
- Myodes voles (2)
- Mysticism (2)
- Myth-Activism (2)
- N ligands (2)
- N-2 reduction (2)
- N-of-1 trial (2)
- N2 (2)
- NAB (2)
- NAC (2)
- NAC transcription factor (2)
- NAFLD/MAFLD (2)
- NAP-XPS (2)
- NBR1 (2)
- NDVI (2)
- NETCONF (2)
- NF1 (2)
- NHCs (2)
- NLO (2)
- NMR structure (2)
- NOR (2)
- NP-completeness (2)
- NTA (2)
- NW Himalaya (2)
- NW Turkey (2)
- Nachhaltige Entwicklung (2)
- Nachwuchsathleten (2)
- Nahrungsnetz (2)
- Nahrungssulfonate (2)
- Namche Barwa (2)
- Nandrolone decanoate (2)
- Nanoeisen (2)
- Nanogranitoids (2)
- Nanohybrid (2)
- Nanoparticle uptake (2)
- Nanostrukturen (2)
- Nanotechnologie (2)
- Nanotoxicology (2)
- Narrative (2)
- Nash equilibrium (2)
- National Socialism (2)
- National-Parks (2)
- Natural Hazards (2)
- Natural products (2)
- Naturgefahr (2)
- Naturschutz (2)
- Nazi Germany (2)
- Near East (2)
- Near-surface geophysics (2)
- Nearshore zone (2)
- Negative (2)
- Negotiation Performance (2)
- Neoliberalism (2)
- Neolithic period (2)
- Neoromicia (2)
- Neotropics (2)
- Nest predation (2)
- Nested graph conditions (2)
- Netherlands (2)
- Network analysis (2)
- Network reconstruction (2)
- Network structure (2)
- Networked foresight (2)
- Netzwerk (2)
- Netzwerkanalyse (2)
- Netzwerke des Wissens (2)
- Neural Networks (2)
- Neuroendocrine tumors (2)
- Neuropeptide Y (2)
- Neurostimulation (2)
- Neutral tone (2)
- Neutrophils (2)
- Nevado Coropuna (2)
- New Guinea (2)
- New Public Governance (2)
- New Spain (2)
- New business formation (2)
- New institutionalism (2)
- Ngizim (2)
- Nichtgleichgewicht (2)
- Nigeria (2)
- Nighttime illumination (2)
- Niobium (2)
- Nitrat (2)
- Nitrogen deposition (2)
- Nitrogen-limitation hypothesis (2)
- Noise-induced phenomena (2)
- Non-canonical sentences (2)
- Non-independent mate choice (2)
- Non-invasive vagus nerve stimulation (2)
- Non-monetary valuation (2)
- Non-monotonic reasoning (2)
- Non-stationarity (2)
- Non-uniqueness (2)
- Nonlinear Laplace operator (2)
- Nonlinear coupling (2)
- Noradrenaline (2)
- Nordic catchments (2)
- Nordic walking (2)
- Nordkorea (2)
- North America (2)
- North Calabrian Unit (2)
- North Iran (2)
- North Korea (2)
- North Pacific (2)
- North Tabriz Fault (2)
- Northern Alpine Foreland Basin (2)
- Northern Sierras Pampeanas (2)
- Northwest Passage (2)
- Northwestern Anatolia (2)
- Norwegian (2)
- Norwegisch (2)
- Nostoc (2)
- Nostoc punctiforme (2)
- Nrf2 (2)
- Nuclear magnetic resonance (2)
- Number-space association (2)
- Numerical experiment (2)
- Numerical modelling (2)
- Numerov's method (2)
- Nursing home (2)
- Nutrient (2)
- Nutritional counseling (2)
- Ny-Alesund (2)
- Nyctereutes procyonoides (2)
- O-antigen specific phage (2)
- OBIA (2)
- OCP-Place (2)
- OMICs tools (2)
- OSL (2)
- OSL dating (2)
- OTDR (2)
- OV–VO (2)
- Oberflächenchemie (2)
- Oberflächenprozesse (2)
- Object Shift (2)
- Obsessive-compulsive disorder (2)
- Ocean acidification (2)
- Ocean color remote sensing (2)
- Ocean sciences (2)
- Oculomotor control (2)
- Offending (2)
- Office chair (2)
- Offspring weight (2)
- Ohrid-Prespa region (2)
- Older adults (2)
- Oligo(epsilon-caprolactone) (2)
- Oligopoly competition (2)
- Oligosaccharides (2)
- Olympic Games (2)
- Omicron (2)
- On-demand release (2)
- Online-Lernen (2)
- Onsager-Machlup functional (2)
- Ontologie (2)
- Ontology (2)
- Opalinus Clay (2)
- Opalinuston (2)
- Open Educational Practices (2)
- OpenForecast (2)
- Ophrys (2)
- Optical remote sensing (2)
- Optical sensor (2)
- Optics and photonics (2)
- Optimalitätstheorie (2)
- Optionality (2)
- OptoGait (2)
- Optoelectronics (2)
- Orbital forcing (2)
- Order-preserving transformations (2)
- Organ Discharge Patterns (2)
- Organic carbon (2)
- Organic electronics (2)
- Organic geochemistry (2)
- Organic matter degradation (2)
- Organic matter mineralization (2)
- Organic semiconductors (2)
- Organisationstheorie (2)
- Ornstein–Uhlenbeck process (2)
- Orogen (2)
- Orogenic wedge (2)
- Orthologous Matrix (OMA) Project (2)
- Orthopedics (2)
- Oryctolagus cuniculus (2)
- Oryza sativa (2)
- Oscillator ensembles (2)
- Ostafrika (2)
- Ostafrikanisches Grabensystem (2)
- Ostdetuschland (2)
- Osteoblast (2)
- Ostracods (2)
- Outcome measures (2)
- Outcrossing rate (2)
- Outdoor enclosure (2)
- Outflows (2)
- Overhead athletes (2)
- Oxygen (2)
- Oxygen saturation (2)
- Oyster Crassostrea-gigas (2)
- P ligands (2)
- P(VDF-TrFE) (2)
- P-waves (2)
- PARAFAC (2)
- PAS domain (2)
- PC-3 cells (2)
- PCK (2)
- PCLake (2)
- PCPDTBT (2)
- PDLC (2)
- PEDOT (2)
- PEI coating (2)
- PER (2)
- PHQ-4 score (2)
- PI3K (2)
- PISA (2)
- PLA (2)
- PLS (2)
- PLS regression (2)
- PLSR (2)
- PLV (2)
- PNIPAM (2)
- POF (2)
- POL (2)
- PPGIS (2)
- PPMS (2)
- PRISM model checker (2)
- PROGRESS/TRIPOD (2)
- PTCTL (2)
- PTEN (2)
- PTSD (2)
- Pain occurrence (2)
- Pain screening (2)
- Pak choi (2)
- Palaeoenvironmental reconstruction (2)
- Palaeogenetics (2)
- Palaeotropics (2)
- Paleoceanography (2)
- Paleoclimate dynamics (2)
- Paleoecology (2)
- Paleoenvironment (2)
- Paleogenetics (2)
- Paleoseismologie (2)
- Palmitate (2)
- Paläogeographie (2)
- Paläoklimadynamik (2)
- Paläomagnetik (2)
- Panama (2)
- Parameterized complexity (2)
- Parasit (2)
- Parasitoid wasp (2)
- Paratethys (2)
- Paraíba (2)
- Paris agreement (2)
- Paris-Edinburgh press (2)
- Parkinson disease (2)
- Parkinson' s disease (2)
- Partial Little Square (2)
- Participant Orientation (2)
- Particle swarm optimization (2)
- Partikelverben (2)
- Partnership (2)
- Passive (2)
- Passive Microwave (2)
- Pastoralism (2)
- Pasture (2)
- Paternity analysis (2)
- Path modelling (2)
- Pathological Narcissism Inventory (2)
- Pathologies (2)
- Pathway design (2)
- Pattern Recognition (2)
- Patterning (2)
- Pause (2)
- Pavlovian‐to‐instrumental transfer (2)
- Peat (2)
- Pedagogical content knowledge (2)
- Pedagogical issues (2)
- Pediastrum (2)
- Peer Assessment (2)
- Peer-to-Peer ridesharing (2)
- Peptid (2)
- Percolation (2)
- Periplaneta americana (2)
- Perm (2)
- Permafrostdegradation (2)
- Peronosporaceae (2)
- Perovskite solar cell (2)
- Perowskit-Solarzellen (2)
- Persian (2)
- Personalised medicine (2)
- Personality traits (2)
- Personalized medicine (2)
- Persönlichkeitsentwicklung (2)
- Perturbed complexes (2)
- Perylene (2)
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- Petrologie (2)
- Pex1 (2)
- Pex6 (2)
- Pfadmodell (2)
- Pflanze (2)
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- Phantoms (2)
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- Phase morphology (2)
- Phenological modelling (2)
- Phenylpropanoids (2)
- Philosophical anthropology (2)
- Phonetik (2)
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- Phonology (2)
- Phononen (2)
- Phosphat (2)
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- Phospholipid (2)
- Phospholipid binding proteins (2)
- Phospholipids (2)
- Phosphorus limitation (2)
- Phosphorylation Site (2)
- Photodynamics (2)
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- Photoexcitations (2)
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- Photometrie (2)
- Photopolymer (2)
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- Photosensitive polymer brushes (2)
- Photosphere (2)
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- Phylogenetic analysis (2)
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- Phylogenie (2)
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- Physical Network (2)
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- Physik (2)
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- Picard-Fuchs equations (2)
- Pichia pastoris (2)
- Picture-word interference (2)
- Piezoelektrizität (2)
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- Pilze (2)
- Pinus pinaster (2)
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- Pipistrellus (2)
- Pipistrellus nathusii (2)
- Pitch (2)
- Plackett–Burman design (2)
- Planar polarity (2)
- PlanetScope (2)
- Planing (2)
- Plant community (2)
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- Plant macrofossils (2)
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- Plant-based diet (2)
- Plasma membrane (2)
- Plasmonics (2)
- Plate tectonics (2)
- Plateau (2)
- Platelets (2)
- Platform Innovation (2)
- Platform economy (2)
- Plato (2)
- Pliocene (2)
- Pluralism (2)
- Podanthus mitiqui (2)
- Poecili-Mexicana (2)
- Poecilia formosa (2)
- Poecilia latipinna (2)
- Poeciliidae (2)
- Poincare inequality (2)
- Point-based rendering (2)
- Point-light action (2)
- Pointing (2)
- Polarization (2)
- Polen (2)
- Policy Reform (2)
- Policy advice (2)
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- Politics & International Relations (2)
- Politics of childhood (2)
- Pollen record (2)
- Pollen trap (2)
- Pollimyrus-Isidori (2)
- Poly(epsilon-caprolactone) (2)
- Polyadenylierung (2)
- Polyelectrolyte (2)
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- Polyelektrolyt-Multischichten (2)
- Polyethyleneimine (2)
- Polymer chemistry (2)
- Polymer dispersions (2)
- Polymerisation (2)
- Polymerization (2)
- Polymerphysik (2)
- Polypeptid (2)
- Polypropylen (2)
- Polysaccharide (2)
- Polyunsaturated Fatty-Acids (2)
- Polyzwitterion (2)
- Pond (2)
- Ponds (2)
- Population density (2)
- Population structure (2)
- Population viability analysis (2)
- Population-Growth (2)
- Porosity (2)
- Porous carbon (2)
- Porous silicon (2)
- Poshtuk metapelites (2)
- Position Generator (2)
- Positive selection (2)
- Postmasburg manganese field (2)
- Postoperative cognitive dysfunction (2)
- Potassium (2)
- Potsdam Grievance Statistics File (PGSF) (2)
- Pragmatik (2)
- Precipitation gradient (2)
- Predation (2)
- Predator-prey interactions (2)
- Prediabetes (2)
- Predictability (2)
- Prediction of disability/intensity (2)
- Predictive processing (2)
- Predictor (2)
- Preference (2)
- Preference Handling (2)
- Preis der Anarchie (2)
- Preprocessing (2)
- Pressure distribution (2)
- Preterm birth (2)
- Price of Anarchy (2)
- Primary school children (2)
- Primates (2)
- Primula (2)
- Prisoner's Dilemma (2)
- Privatsphäre (2)
- Proactive/reactive balance (2)
- Proactivity (2)
- Probability (2)
- Probability distributions (2)
- Problem Solving (2)
- Problem solving (2)
- Process Enactment (2)
- Process Modelling (2)
- Process model (2)
- Procrustes rotation (2)
- Progesterone (2)
- Prognose (2)
- Programming (2)
- Projection (2)
- Projektion (2)
- Proliferation (2)
- Prominences, active (2)
- Promiscuous enzymes (2)
- Pronoun resolution (2)
- Prosodic boundaries (2)
- Prosody-syntax interface (2)
- Prospective (2)
- Proteasome (2)
- Protective factors (2)
- Protein expression (2)
- Protein oxidation (2)
- Protein restriction (2)
- Protein secondary structure (2)
- Protein-Engineering (2)
- Proteinaggregation (2)
- Protein–protein interaction (2)
- Proxy (2)
- Prozessausführung (2)
- Präferenzen (2)
- Prävalenz (2)
- Pseudomonas syringae (2)
- Psychodiagnostics (2)
- Psycholinguistics (2)
- Psychological functioning (2)
- Psychometric evaluation (2)
- Psychopathology (2)
- Psychophysiology (2)
- Psychosocial stress (2)
- Psychotherapeutic competencies (2)
- Psychotherapie (2)
- Public Management (2)
- Public Service Motivation (2)
- Public organizations (2)
- Pull-Apart (2)
- Pulling isometric muscle action (2)
- Pump-probe (2)
- Punch (2)
- Pupillometrie (2)
- Push-pull character (2)
- Push-pull effect (2)
- Puumala virus seroprevalence (2)
- QCA (2)
- QDs (2)
- QTL mapping (2)
- Qaidam Basin (2)
- Qilian mountains (2)
- Quality assurance (2)
- Quality of Life (2)
- Quantendraht (2)
- Quantenoptik (2)
- Quantenpunkt (2)
- Quantenpunkte (2)
- Quantum Dots (2)
- Quantum dots (2)
- Quantum optics (2)
- Quartz (2)
- Quartär (2)
- Quasar (2)
- Quasars (2)
- Quercus (2)
- Quercus ilex (2)
- Quercus pubescens (2)
- Query optimization (2)
- R (2)
- R Shiny (2)
- RAFT-Polymerisation (2)
- RCP scenarios (2)
- RCT (2)
- RDF (2)
- REDD+ (2)
- REE (2)
- REVEALS (2)
- RGB-D cameras (2)
- RIXS (resonant inelastic X-ray scattering) (2)
- RNA interference (2)
- RNA virus (2)
- ROF1 (2)
- ROK (2)
- ROMP (2)
- ROP (2)
- RP-HPLC (2)
- RP2 (2)
- RRR (2)
- RSI (2)
- RT models (2)
- RUNX2 (2)
- Radiative transfer (2)
- Radiogenic isotopes (2)
- Rainfall (2)
- Rainfall gradient (2)
- Raman imaging (2)
- Raman microspectroscopy (2)
- Randelementmethode (2)
- Randomized controlled-trails (2)
- Randwertprobleme (2)
- Ranking (2)
- Rapeseed oil (2)
- Raphidiopsis (2)
- Rapid automatized naming (2)
- Rasa (2)
- Rationality (2)
- Rattus rattus (2)
- Rauheit (2)
- Raumzeitgeometrie (2)
- Rauschinduzierte Phänomene (2)
- Rayleigh waves (2)
- Rb-Sr mineral isochrons (2)
- Reactive oxygen species (2)
- Real time (2)
- Realismus (2)
- Realistic Accuracy (2)
- Reanalysis (2)
- Rearing experiment (2)
- Rearrangement (2)
- Reasoning (2)
- Receiver functions (2)
- Rechenschaftspflicht (2)
- Recognition Memory (2)
- Recollection (2)
- Recombinase polymerase amplification (2)
- Recombination (2)
- Recurrence Plots (2)
- Recurrence plots (2)
- Red Cross (2)
- Redox (2)
- Redox marker (2)
- Redox polymer (2)
- Redoxreaktion (2)
- Redundancy (2)
- Reflectivity (2)
- Reflexion (2)
- Reflexionsseismik (2)
- Reflexives (2)
- Reflexivpronomen (2)
- Reform Judaism (2)
- Reformjudentum (2)
- Refugee Tales (2)
- Regime shifts (2)
- Regionalization (2)
- Regularization (2)
- Regulatory focus (2)
- Regulierung (2)
- Rehearsal (2)
- Reinforcement Learning (2)
- Rekonstruktionsmethoden (2)
- Rekurrenzplot (2)
- Relapse (2)
- Relation historique (2)
- Relative clause (2)
- Relative clauses (2)
- Relativized Minimality (2)
- Release (2)
- Relevanz (2)
- Religiosity (2)
- Remote Sensing (2)
- Removable sets (2)
- Renal failure (2)
- Renal function (2)
- Renewable energy (2)
- Renewable resources (2)
- Reparaturen (2)
- Repeated sprint (2)
- Replication (2)
- Reproducibility (2)
- Reproducible benchmarking (2)
- Reproducing kernel Hilbert space (2)
- Republik Korea (2)
- ResNet (2)
- Reservoir Networks (2)
- Residual stresses (2)
- Resiliency (2)
- Resolved and unresolved sources as a function of wavelength (2)
- Resonances (2)
- Resource Competition (2)
- Ressourcenoptimierung (2)
- Resurvey (2)
- Retention (2)
- Reticulocytes (2)
- Retina (2)
- Retinyl esters (2)
- Revenue Autonomy (2)
- Rheic Ocean (2)
- Rheological modeling (2)
- Rhine River (2)
- Rhizophagus irregularis (2)
- RiPPs (2)
- Ribosome (2)
- Ribosome profiling (2)
- Richard Schomburgk (2)
- Riesenvesikel (2)
- Riesz continuity (2)
- Ring tensiometry (2)
- Ring-opening polymerization (2)
- Rings (2)
- Rio Grande (2)
- Risiko (2)
- Risk factor (2)
- Risk perception (2)
- River Incision Model (2)
- River restoration (2)
- River-Basin (2)
- Robustness (2)
- Rodent (2)
- Rohstoffe (2)
- Role-playing (2)
- Romania (2)
- Roridula gorgonias (2)
- Rossby waves (2)
- Rossby-normal modes (2)
- Rotifier (2)
- Rougon-Macquart (2)
- Royden boundary (2)
- RpoS (2)
- RuBisCO (2)
- Rubisco (2)
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- anorexia (2)
- anorexia nervosa (2)
- anoxia (2)
- antecedent choice (2)
- antecedents (2)
- anterior PNP (2)
Institute
- Institut für Physik und Astronomie (5047)
- Institut für Biochemie und Biologie (4791)
- Institut für Geowissenschaften (3388)
- Institut für Chemie (2931)
- Institut für Mathematik (1890)
- Department Psychologie (1500)
- Institut für Ernährungswissenschaft (1056)
- Department Linguistik (1029)
- Wirtschaftswissenschaften (860)
- Institut für Informatik und Computational Science (844)
Research on novel and advanced biomaterials is an indispensable step towards their applications in desirable fields such as tissue engineering, regenerative medicine, cell culture, or biotechnology. The work presented here focuses on such a promising material: polyelectrolyte multilayer (PEM) composed of hyaluronic acid (HA) and poly(L-lysine) (PLL). This gel-like polymer surface coating is able to accumulate (bio-)molecules such as proteins or drugs and release them in a controlled manner. It serves as a mimic of the extracellular matrix (ECM) in composition and intrinsic properties. These qualities make the HA/PLL multilayers a promising candidate for multiple bio-applications such as those mentioned above. The work presented aims at the development of a straightforward approach for assessment of multi-fractional diffusion in multilayers (first part) and at control of local molecular transport into or from the multilayers by laser light trigger (second part).
The mechanism of the loading and release is governed by the interaction of bioactives with the multilayer constituents and by the diffusion phenomenon overall. The diffusion of a molecule in HA/PLL multilayers shows multiple fractions of different diffusion rate. Approaches, that are able to assess the mobility of molecules in such a complex system, are limited. This shortcoming motivated the design of a novel evaluation tool presented here.
The tool employs a simulation-based approach for evaluation of the data acquired by fluorescence recovery after photobleaching (FRAP) method. In this approach, possible fluorescence recovery scenarios are primarily simulated and afterwards compared with the data acquired while optimizing parameters of a model until a sufficient match is achieved. Fluorescent latex particles of different sizes and fluorescein in an aqueous medium are utilized as test samples validating the analysis results. The diffusion of protein cytochrome c in HA/PLL multilayers is evaluated as well.
This tool significantly broadens the possibilities of analysis of spatiotemporal FRAP data, which originate from multi-fractional diffusion, while striving to be widely applicable. This tool has the potential to elucidate the mechanisms of molecular transport and empower rational engineering of the drug release systems.
The second part of the work focuses on the fabrication of such a spatiotemporarily-controlled drug release system employing the HA/PLL multilayer. This release system comprises different layers of various functionalities that together form a sandwich structure. The bottom layer, which serves as a reservoir, is formed by HA/PLL PEM deposited on a planar glass substrate. On top of the PEM, a layer of so-called hybrids is deposited. The hybrids consist of thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) -based hydrogel microparticles with surface-attached gold nanorods. The layer of hybrids is intended to serve as a gate that controls the local molecular transport through the PEM–solution-interface. The possibility of stimulating the molecular transport by near-infrared (NIR) laser irradiation is being explored.
From several tested approaches for the deposition of hybrids onto the PEM surface, the drying-based approach was identified as optimal. Experiments, that examine the functionality of the fabricated sandwich at elevated temperature, document the reversible volume phase transition of the PEM-attached hybrids while sustaining the sandwich stability. Further, the gold nanorods were shown to effectively absorb light radiation in the tissue- and cell-friendly NIR spectral region while transducing the energy of light into heat. The rapid and reversible shrinkage of the PEM-attached hybrids was thereby achieved. Finally, dextran was employed as a model transport molecule. It loads into the PEM reservoir in a few seconds with the partition constant of 2.4, while it spontaneously releases in a slower, sustained manner. The local laser irradiation of the sandwich, which contains the fluorescein isothiocyanate tagged dextran, leads to a gradual reduction of fluorescence intensity in the irradiated region.
The release system fabricated employs renowned photoresponsivity of the hybrids in an innovative setting. The results of the research are a step towards a spatially-controlled on-demand drug release system that paves the way to spatiotemporally controlled drug release.
The approaches developed in this work have the potential to elucidate the molecular dynamics in ECM and to foster engineering of multilayers with properties tuned to mimic the ECM. The work aims at spatiotemporal control over the diffusion of bioactives and their presentation to the cells.
On doubling unconditionals
(2019)
The large literature that aims to find evidence of climate migration delivers mixed findings. This meta-regression analysis i) summarizes direct links between adverse climatic events and migration, ii) maps patterns of climate migration, and iii) explains the variation in outcomes. Using a set of limited dependent variable models, we meta-analyze thus-far the most comprehensive sample of 3,625 estimates from 116 original studies and produce novel insights on climate migration. We find that extremely high temperatures and drying conditions increase migration. We do not find a significant effect of sudden-onset events. Climate migration is most likely to emerge due to contemporaneous events, to originate in rural areas and to take place in middle-income countries, internally, to cities. The likelihood to become trapped in affected areas is higher for women and in low-income countries, particularly in Africa. We uniquely quantify how pitfalls typical for the broader empirical climate impact literature affect climate migration findings. We also find evidence of different publication biases.
In this paper, we move from the large strand of research that looks at evidence of climate migration to the questions: who are the climate migrants? and where do they go? These questions are crucial to design policies that mitigate welfare losses of migration choices due to climate change. We study the direct and heterogeneous associations between weather extremes and migration in rural India. We combine ERAS reanalysis data with the India Human Development Survey household panel and conduct regression analyses by applying linear probability and multinomial logit models. This enables us to establish a causal relationship between temperature and precipitation anomalies and overall migration as well as migration by destination. We show that adverse weather shocks decrease rural-rural and international migration and push people into cities in different, presumably more prosperous states. A series of positive weather shocks, however, facilitates international migration and migration to cities within the same state. Further, our results indicate that in contrast to other migrants, climate migrants are likely to be from the lower end of the skill distribution and from households strongly dependent on agricultural production. We estimate that approximately 8% of all rural-urban moves between 2005 and 2012 can be attributed to weather. This figure might increase as a consequence of climate change. Thus, a key policy recommendation is to take steps to facilitate integration of less educated migrants into the urban labor market.
While estimated numbers of past and future climate migrants are alarming, the growing empirical evidence suggests that the association between adverse climate-related events and migration is not universally positive. This dissertation seeks to advance our understanding of when and how climate migration emerges by analyzing heterogeneous climatic influences on migration in low- and middle-income countries. To this end, it draws on established economic theories of migration, datasets from physical and social sciences, causal inference techniques and approaches from systematic literature review. In three of its five chapters, I estimate causal effects of processes of climate change on inequality and migration in India and Sub-Saharan Africa. By employing interaction terms and by analyzing sub-samples of data, I explore how these relationships differ for various segments of the population. In the remaining two chapters, I present two systematic literature reviews. First, I undertake a comprehensive meta-regression analysis of the econometric climate migration literature to summarize general climate migration patterns and explain the conflicting findings. Second, motivated by the broad range of approaches in the field, I examine the literature from a methodological perspective to provide best practice guidelines for studying climate migration empirically. Overall, the evidence from this dissertation shows that climatic influences on human migration are highly heterogeneous. Whether adverse climate-related impacts materialize in migration depends on the socio-economic characteristics of the individual households, such as wealth, level of education, agricultural dependence or access to adaptation technologies and insurance. For instance, I show that while adverse climatic shocks are generally associated with an increase in migration in rural India, they reduce migration in the agricultural context of Sub-Saharan Africa, where the average wealth levels are much lower so that households largely cannot afford the upfront costs of moving. I find that unlike local climatic shocks which primarily enhance internal migration to cities and hence accelerate urbanization, shocks transmitted via agricultural producer prices increase migration to neighboring countries, likely due to the simultaneous decrease in real income in nearby urban areas. These findings advance our current understanding by showing when and how economic agents respond to climatic events, thus providing explicit contexts and mechanisms of climate change effects on migration in the future. The resulting collection of findings can guide policy interventions to avoid or mitigate any present and future welfare losses from climate change-related migration choices.
We show that the codifference is a useful tool in studying the ergodicity breaking and non-Gaussianity properties of stochastic time series. While the codifference is a measure of dependence that was previously studied mainly in the context of stable processes, we here extend its range of applicability to random-parameter and diffusing-diffusivity models which are important in contemporary physics, biology and financial engineering. We prove that the codifference detects forms of dependence and ergodicity breaking which are not visible from analysing the covariance and correlation functions. We also discuss a related measure of dispersion, which is a nonlinear analogue of the mean squared displacement.
We show that the codifference is a useful tool in studying the ergodicity breaking and non-Gaussianity properties of stochastic time series. While the codifference is a measure of dependence that was previously studied mainly in the context of stable processes, we here extend its range of applicability to random-parameter and diffusing-diffusivity models which are important in contemporary physics, biology and financial engineering. We prove that the codifference detects forms of dependence and ergodicity breaking which are not visible from analysing the covariance and correlation functions. We also discuss a related measure of dispersion, which is a nonlinear analogue of the mean squared displacement.
Recent advances in single particle tracking and supercomputing techniques demonstrate the emergence of normal or anomalous, viscoelastic diffusion in conjunction with non-Gaussian distributions in soft, biological, and active matter systems. We here formulate a stochastic model based on a generalised Langevin equation in which non-Gaussian shapes of the probability density function and normal or anomalous diffusion have a common origin, namely a random parametrisation of the stochastic force. We perform a detailed analysis demonstrating how various types of parameter distributions for the memory kernel result in exponential, power law, or power-log law tails of the memory functions. The studied system is also shown to exhibit a further unusual property: the velocity has a Gaussian one point probability density but non-Gaussian joint distributions. This behaviour is reflected in the relaxation from a Gaussian to a non-Gaussian distribution observed for the position variable. We show that our theoretical results are in excellent agreement with stochastic simulations.
Recent advances in single particle tracking and supercomputing techniques demonstrate the emergence of normal or anomalous, viscoelastic diffusion in conjunction with non-Gaussian distributions in soft, biological, and active matter systems. We here formulate a stochastic model based on a generalised Langevin equation in which non-Gaussian shapes of the probability density function and normal or anomalous diffusion have a common origin, namely a random parametrisation of the stochastic force. We perform a detailed analysis demonstrating how various types of parameter distributions for the memory kernel result in exponential, power law, or power-log law tails of the memory functions. The studied system is also shown to exhibit a further unusual property: the velocity has a Gaussian one point probability density but non-Gaussian joint distributions. This behaviour is reflected in the relaxation from a Gaussian to a non-Gaussian distribution observed for the position variable. We show that our theoretical results are in excellent agreement with stochastic simulations.
Many studies on biological and soft matter systems report the joint presence of a linear mean-squared displacement and a non-Gaussian probability density exhibiting, for instance, exponential or stretched-Gaussian tails. This phenomenon is ascribed to the heterogeneity of the medium and is captured by random parameter models such as ‘superstatistics’ or ‘diffusing diffusivity’. Independently, scientists working in the area of time series analysis and statistics have studied a class of discrete-time processes with similar properties, namely, random coefficient autoregressive models. In this work we try to reconcile these two approaches and thus provide a bridge between physical stochastic processes and autoregressive models.Westart from the basic Langevin equation of motion with time-varying damping or diffusion coefficients and establish the link to random coefficient autoregressive processes. By exploring that link we gain access to efficient statistical methods which can help to identify data exhibiting Brownian yet non-Gaussian diffusion.
Many studies on biological and soft matter systems report the joint presence of a linear mean-squared displacement and a non-Gaussian probability density exhibiting, for instance, exponential or stretched-Gaussian tails. This phenomenon is ascribed to the heterogeneity of the medium and is captured by random parameter models such as ‘superstatistics’ or ‘diffusing diffusivity’. Independently, scientists working in the area of time series analysis and statistics have studied a class of discrete-time processes with similar properties, namely, random coefficient autoregressive models. In this work we try to reconcile these two approaches and thus provide a bridge between physical stochastic processes and autoregressive models.Westart from the basic Langevin equation of motion with time-varying damping or diffusion coefficients and establish the link to random coefficient autoregressive processes. By exploring that link we gain access to efficient statistical methods which can help to identify data exhibiting Brownian yet non-Gaussian diffusion.
Background:
Plant phenotypic data shrouds a wealth of information which, when accurately analysed and linked
to other data types, brings to light the knowledge about the mechanisms of life. As phenotyping is a field of research
comprising manifold, diverse and time
‑consuming experiments, the findings can be fostered by reusing and combin‑
ing existing datasets. Their correct interpretation, and thus replicability, comparability and interoperability, is possible
provided that the collected observations are equipped with an adequate set of metadata. So far there have been no
common standards governing phenotypic data description, which hampered data exchange and reuse.
Results:
In this paper we propose the guidelines for proper handling of the information about plant phenotyping
experiments, in terms of both the recommended content of the description and its formatting. We provide a docu‑
ment called “Minimum Information About a Plant Phenotyping Experiment”, which specifies what information about
each experiment should be given, and a Phenotyping Configuration for the ISA
‑Tab format, which allows to practically
organise this information within a dataset. We provide examples of ISA
‑Tab
‑formatted phenotypic data, and a general
description of a few systems where the recommendations have been implemented.
Conclusions:
Acceptance of the rules described in this paper by the plant phenotyping community will help to
achieve findable, accessible, interoperable and reusable data.
The Proteasome Acts as a Hub for Plant Immunity and Is Targeted by Pseudomonas Type III Effectors
(2016)
Recent evidence suggests that the ubiquitin-proteasome system is involved in several aspects of plant immunity and that a range of plant pathogens subvert the ubiquitin-proteasome system to enhance their virulence. Here, we show that proteasome activity is strongly induced during basal defense in Arabidopsis (Arabidopsis thaliana). Mutant lines of the proteasome subunits RPT2a and RPN12a support increased bacterial growth of virulent Pseudomonas syringae pv tomato DC3000 (Pst) and Pseudomonas syringae pv maculicola ES4326. Both proteasome subunits are required for pathogen-associated molecular pattern-triggered immunity responses. Analysis of bacterial growth after a secondary infection of systemic leaves revealed that the establishment of systemic acquired resistance (SAR) is impaired in proteasome mutants, suggesting that the proteasome also plays an important role in defense priming and SAR. In addition, we show that Pst inhibits proteasome activity in a type III secretion-dependent manner. A screen for type III effector proteins from Pst for their ability to interfere with proteasome activity revealed HopM1, HopAO1, HopA1, and HopG1 as putative proteasome inhibitors. Biochemical characterization of HopM1 by mass spectrometry indicates that HopM1 interacts with several E3 ubiquitin ligases and proteasome subunits. This supports the hypothesis that HopM1 associates with the proteasome, leading to its inhibition. Thus, the proteasome is an essential component of pathogen-associated molecular pattern-triggered immunity and SAR, which is targeted by multiple bacterial effectors.
XopJ is a Xanthomonas type III effector protein that promotes bacterial virulence on susceptible pepper plants through the inhibition of the host cell proteasome and a resultant suppression of salicylic acid (SA) - dependent defense responses. We show here that Nicotiana benthamiana leaves transiently expressing XopJ display hypersensitive response (HR) -like symptoms when exogenously treated with SA. This apparent avirulence function of XopJ was further dependent on effector myristoylation as well as on an intact catalytic triad, suggesting a requirement of its enzymatic activity for HR-like symptom elicitation. The ability of XopJ to cause a HR-like symptom development upon SA treatment was lost upon silencing of SGT1 and NDR1, respectively, but was independent of EDS1 silencing, suggesting that XopJ is recognized by an R protein of the CC-NBS-LRR class. Furthermore, silencing of NPR1 abolished the elicitation of HR-like symptoms in XopJ expressing leaves after SA application. Measurement of the proteasome activity indicated that proteasome inhibition by XopJ was alleviated in the presence of SA, an effect that was not observed in NPR1 silenced plants. Our results suggest that XopJ - triggered HR-like symptoms are closely related to the virulence function of the effector and that XopJ follows a two-signal model in order to elicit a response in the non-host plant N. benthamiana.
XopJ is a Xanthomonas type III effector protein that promotes bacterial virulence on susceptible pepper plants through the inhibition of the host cell proteasome and a resultant suppression of salicylic acid (SA) - dependent defense responses. We show here that Nicotiana benthamiana leaves transiently expressing XopJ display hypersensitive response (HR) -like symptoms when exogenously treated with SA. This apparent avirulence function of XopJ was further dependent on effector myristoylation as well as on an intact catalytic triad, suggesting a requirement of its enzymatic activity for HR-like symptom elicitation. The ability of XopJ to cause a HR-like symptom development upon SA treatment was lost upon silencing of SGT1 and NDR1, respectively, but was independent of EDS1 silencing, suggesting that XopJ is recognized by an R protein of the CC-NBS-LRR class. Furthermore, silencing of NPR1 abolished the elicitation of HR-like symptoms in XopJ expressing leaves after SA application. Measurement of the proteasome activity indicated that proteasome inhibition by XopJ was alleviated in the presence of SA, an effect that was not observed in NPR1 silenced plants. Our results suggest that XopJ - triggered HR-like symptoms are closely related to the virulence function of the effector and that XopJ follows a two-signal model in order to elicit a response in the non-host plant N. benthamiana.
Quantitative estimates of sea-level rise in the Mediterranean Basin become increasingly accurate thanks to detailed satellite monitoring. However, such measuring campaigns cover several years to decades, while longer-term sea-level records are rare for the Mediterranean. We used a data archeological approach to reanalyze monthly mean sea-level data of the Antalya-I (1935–1977) tide gauge to fill this gap. We checked the accuracy and reliability of these data before merging them with the more recent records of the Antalya-II (1985–2009) tide gauge, accounting for an eight-year hiatus. We obtain a composite time series of monthly and annual mean sea levels spanning some 75 years, providing the longest record for the eastern Mediterranean Basin, and thus an essential tool for studying the region's recent sea-level trends. We estimate a relative mean sea-level rise of 2.2 ± 0.5 mm/year between 1935 and 2008, with an annual variability (expressed here as the standard deviation of the residuals, σresiduals = 41.4 mm) above that at the closest tide gauges (e.g., Thessaloniki, Greece, σresiduals = 29.0 mm). Relative sea-level rise accelerated to 6.0 ± 1.5 mm/year at Antalya-II; we attribute roughly half of this rate (~3.6 mm/year) to tectonic crustal motion and anthropogenic land subsidence. Our study highlights the value of data archeology for recovering and integrating historic tide gauge data for long-term sea-level and climate studies.
Landslides are frequent natural hazards in rugged terrain, when the resisting frictional force of the surface of rupture yields to the gravitational force. These forces are functions of geological and morphological factors, such as angle of internal friction, local slope gradient or curvature, which remain static over hundreds of years; whereas more dynamic triggering events, such as rainfall and earthquakes, compromise the force balance by temporarily reducing resisting forces or adding transient loads. This thesis investigates landslide distribution and orientation due to landslide triggers (e.g. rainfall) at different scales (6-4∙10^5 km^2) and aims to link rainfall movement with the landslide distribution. It additionally explores the local impacts of the extreme rainstorms on landsliding and the role of precursory stability conditions that could be induced by an earlier trigger, such as an earthquake.
Extreme rainfall is a common landslide trigger. Although several studies assessed rainfall intensity and duration to study the distribution of thus triggered landslides, only a few case studies quantified spatial rainfall patterns (i.e. orographic effect). Quantifying the regional trajectories of extreme rainfall could aid predicting landslide prone regions in Japan. To this end, I combined a non-linear correlation metric, namely event synchronization, and radial statistics to assess the general pattern of extreme rainfall tracks over distances of hundreds of kilometers using satellite based rainfall estimates. Results showed that, although the increase in rainfall intensity and duration positively correlates with landslide occurrence, the trajectories of typhoons and frontal storms were insufficient to explain landslide distribution in Japan. Extreme rainfall trajectories inclined northwestwards and were concentrated along some certain locations, such as coastlines of southern Japan, which was unnoticed in the landslide distribution of about 5000 rainfall-triggered landslides. These landslides seemed to respond to the mean annual rainfall rates.
Above mentioned findings suggest further investigation on a more local scale to better understand the mechanistic response of landscape to extreme rainfall in terms of landslides. On May 2016 intense rainfall struck southern Germany triggering high waters and landslides. The highest damage was reported at the Braunsbach, which is located on the tributary-mouth fan formed by the Orlacher Bach. Orlacher Bach is a ~3 km long creek that drains a catchment of about ~6 km^2. I visited this catchment in June 2016 and mapped 48 landslides along the creek. Such high landslide activity was not reported in the nearby catchments within ~3300 km^2, despite similar rainfall intensity and duration based on weather radar estimates. My hypothesis was that several landslides were triggered by rainfall-triggered flash floods that undercut hillslope toes along the Orlacher Bach. I found that morphometric features such as slope and curvature play an important role in landslide distribution on this micro scale study site (<10 km^2). In addition, the high number of landslides along the Orlacher Bach could also be boosted by accumulated damages on hillslopes due karst weathering over longer time scales.
Precursory damages on hillslopes could also be induced by past triggering events that effect landscape evolution, but this interaction is hard to assess independently from the latest trigger. For example, an earthquake might influence the evolution of a landscape decades long, besides its direct impacts, such as landslides that follow the earthquake. Here I studied the consequences of the 2016 Kumamoto Earthquake (MW 7.1) that triggered some 1500 landslides in an area of ~4000 km^2 in central Kyushu, Japan. Topography, i.e. local slope and curvature, both amplified and attenuated seismic waves, thus controlling the failure mechanism of those landslides (e.g. progressive). I found that topography fails in explaining the distribution and the preferred orientation of the landslides after the earthquake; instead the landslides were concentrated around the northeast of the rupture area and faced mostly normal to the rupture plane. This preferred location of the landslides was dominated mainly by the directivity effect of the strike-slip earthquake, which is the propagation of wave energy along the fault in the rupture direction; whereas amplitude variations of the seismic radiation altered the preferred orientation. I suspect that the earthquake directivity and the asymmetry of seismic radiation damaged hillslopes at those preferred locations increasing landslide susceptibility. Hence a future weak triggering event, e.g. scattered rainfall, could further trigger landslides at those damaged hillslopes.
Turkish is a language described as relying predominantly on non-finite subordination in the domain of clause combining. However, there are also strategies of finite subordination, as well as means of syndetic and asyndetic paratactic clause combining, especially in the informal settings.
Clause combining is and has been one of the focal points of research on heritage Turkish (h-Turkish).
One point is particularly clear: In comparison with the monolingual setting, finite means of clause combining are more frequent in h-Turkish in Germany, the U.S., and the Netherlands, while non-finite means of clause combining are less frequent.
Overall, our results confirm the findings of earlier studies: heritage speakers in Germany and the U.S. prefer paratactic means of clause combining using connectors, as opposed to monolingual speakers.
Our results also reveal that age (adolescents vs. adults) and register (informal vs. formal) significantly modulate the use of connectors.
Moreover, we find that the shift in preferences in means of clause combining triggers an expansion in the system of connectors and leads to the development of new narrative connectors, such as o zaman and derken.
The system of syndetic paratactic clause combining is expanding in heritage Turkish. This expansion calls for multifaceted modeling of change in heritage languages, which integrates language-internal factors (register), dynamics of convergence with the contact languages, and extra-linguistic factors (age and language use).
Reading requires the assembly of cognitive processes across a wide spectrum from low-level visual perception to high-level discourse comprehension. One approach of unravelling the dynamics associated with these processes is to determine how eye movements are influenced by the characteristics of the text, in particular which features of the words within the perceptual span maximise the information intake due to foveal, spillover, parafoveal, and predictive processing. One way to test the generalisability of current proposals of such distributed processing is to examine them across different languages. For Turkish, an agglutinative language with a shallow orthography-phonology mapping, we replicate the well-known canonical main effects of frequency and predictability of the fixated word as well as effects of incoming saccade amplitude and fixation location within the word on single-fixation durations with data from 35 adults reading 120 nine-word sentences. Evidence for previously reported effects of the characteristics of neighbouring words and interactions was mixed. There was no evidence for the expected Turkish-specific morphological effect of the number of inflectional suffixes on single-fixation durations. To control for word-selection bias associated with single-fixation durations, we also tested effects on word skipping, single-fixation, and multiple-fixation cases with a base-line category logit model, assuming an increase of difficulty for an increase in the number of fixations. With this model, significant effects of word characteristics and number of inflectional suffixes of foveal word on probabilities of the number of fixations were observed, while the effects of the characteristics of neighbouring words and interactions were mixed.
Because of political conflicts and climate change, migration will be increased worldwide and integration in host societies is a challenge also for migrants. We hypothesize that migrants, who take up the challenge in a new social environment are taller than migrants who do not pose this challenge. We analyze by a questionnaire possible social, nutritional and ethnic influencing factors to body height (BH) of adult offspring of Turkish migrants (n = 82, 39 males) aged from 18 to 34 years (mean age 24.6 years). The results of multiple regression (downward selection) show that the more a male adult offspring of Turkish migrants feels like belonging to the Turkish culture, the smaller he is (95% CI, -3.79, -0.323). Further, the more a male adult offspring of Turkish migrants feels like belonging to the German culture, the taller he is (95% CI, -0.152, 1.738). We discussed it comparable to primates taking up their challenge in dominance, where as a result their body size increase is associated with higher IGF-1 level. IGF-1 is associated with emotional belonging and has a fundamental role in the regulation of metabolism and growth of the human body. With all pilot characteristics of our study results show that the successful challenge of integration in a new society is strongly associated with the emotional integration and identification in the sense of a personal sense of belonging to society. We discuss taller BH as a signal of social growth adjustment. In this sense, a secular trend of BH adaptation of migrants to hosts is a sign of integration.
If taking a flipped learning approach, MOOC content can be used for online pre-class instruction. After which students can put the knowledge they gained from the MOOC into practice either synchronously or asynchronously. This study examined one such, asynchronous, course in teacher education. The course ran with 40 students over 13 weeks from February to May 2020. A case study approach was followed using mixed methods to assess the efficacy of the course. Quantitative data was gathered on achievement of learning outcomes, online engagement, and satisfaction. Qualitative data was gathered via student interviews from which a thematic analysis was undertaken. From a combined analysis of the data, three themes emerged as pertinent to course efficacy: quality and quantity of communication and collaboration; suitability of the MOOC; and significance for career development.
In this study, the spatial and temporal impacts of the Ataturk Dam on agro-meteorological aspects of the Southeastern Anatolia region have been investigated. Change detection and environmental impacts due to water-reserve changes in Ataturk Dam Lake have been determined and evaluated using multi-temporal Landsat satellite imageries and meteorological datasets within a period of 1984-2011. These time series have been evaluated for three time periods. Dam construction period constitutes the first part of the study. Land cover/use changes especially on agricultural fields under the Ataturk Dam Lake and its vicinity have been identified between the periods of 1984-1992. The second period comprises the 10-year period after the completion of filling up the reservoir in 1992. At this period, Landsat and meteorological time-series analyses are examined to assess the impact of the Ataturk Dam Lake on selected irrigated agricultural areas. For the last 9-year period from 2002 to 2011, the relationships between seasonal water-reserve changes and irrigated plains under changing climatic factors primarily driving vegetation activity (monthly, seasonal, and annual fluctuations of rainfall rate, air temperature, humidity) on the watershed have been investigated using a 30-year meteorological time series. The results showed that approximately 368 km(2) of agricultural fields have been affected because of inundation due to the Ataturk Dam Lake. However, irrigated agricultural fields have been increased by 56.3% of the total area (1552 of 2756 km(2)) on Harran Plain within the period of 1984-2011.
We present the fabrication of TiO2 nanotube electrodes with high biocompatibility and extraordinary spectroscopic properties. Intense surface-enhanced resonance Raman signals of the heme unit of the redox enzyme Cytochromeb(5) were observed upon covalent immobilization of the protein matrix on the TiO2 surface, revealing overall preserved structural integrity and redox behavior. The enhancement factor could be rationally controlled by varying the electrode annealing temperature, reaching a record maximum value of over 70 at 475 degrees C. For the first time, such high values are reported for non-directly surface-interacting probes, for which the involvement of charge-transfer processes in signal amplification can be excluded. The origin of the surface enhancement is exclusively attributed to enhanced localized electric fields resulting from the specific optical properties of the nanotubular geometry of the electrode.
The Sun is a star, which due to its proximity has a tremendous influence on Earth. Since its very first days mankind tried to "understand the Sun", and especially in the 20th century science has uncovered many of the Sun's secrets by using high resolution observations and describing the Sun by means of models. As an active star the Sun's activity, as expressed in its magnetic cycle, is closely related to the sunspot numbers. Flares play a special role, because they release large energies on very short time scales. They are correlated with enhanced electromagnetic emissions all over the spectrum. Furthermore, flares are sources of energetic particles. Hard X-ray observations (e.g., by NASA's RHESSI spacecraft) reveal that a large fraction of the energy released during a flare is transferred into the kinetic energy of electrons. However the mechanism that accelerates a large number of electrons to high energies (beyond 20 keV) within fractions of a second is not understood yet. The thesis at hand presents a model for the generation of energetic electrons during flares that explains the electron acceleration based on real parameters obtained by real ground and space based observations. According to this model photospheric plasma flows build up electric potentials in the active regions in the photosphere. Usually these electric potentials are associated with electric currents closed within the photosphere. However as a result of magnetic reconnection, a magnetic connection between the regions of different magnetic polarity on the photosphere can establish through the corona. Due to the significantly higher electric conductivity in the corona, the photospheric electric power supply can be closed via the corona. Subsequently a high electric current is formed, which leads to the generation of hard X-ray radiation in the dense chromosphere. The previously described idea is modelled and investigated by means of electric circuits. For this the microscopic plasma parameters, the magnetic field geometry and hard X-ray observations are used to obtain parameters for modelling macroscopic electric components, such as electric resistors, which are connected with each other. This model demonstrates that such a coronal electric current is correlated with large scale electric fields, which can accelerate the electrons quickly up to relativistic energies. The results of these calculations are encouraging. The electron fluxes predicted by the model are in agreement with the electron fluxes deduced from the measured photon fluxes. Additionally the model developed in this thesis proposes a new way to understand the observed double footpoint hard X-ray sources.
We develop a method of finding analytical sotutions of the Bogolyubov-de Gennes equations for the excitations of a Bose condensate in the Thomas-Fermi regime in harmonic traps of any asymmetry and introduce a classification of eigenstates. In the case of cylindrical symmetry we emphasize the presence of an accidental degeneracy in the excitation spectrum at certain values of the projection of orbital angular momentum on the symmetry axis and discuss possible consequences of the degeneracy in the context of new signatures of Bose- Einstein condensation
Content: 1. Introduction 2. Early Examples of the AFP in Hiberno-English 3. Assessments of the Evidence 4. Attempts to Explain the Early HE Construction 5. Distribution and Function of the AFP in EMI and HE 5.1. The AFP with the Future Tense in Irish 5.2. The AFP with the Secondary Future or Conditional 5.3. The AFP with the Subjunctive 5.5. Functions of the AFP in Early Modern Irish and HE 6. The Restriction of the AFP to the Recent Perfect 7. Conclusions
Next-generation sequencing methods provide comprehensive data for the analysis of structural and functional analysis of the genome. The draft genomes with low contig number and high N50 value can give insight into the structure of the genome as well as provide information on the annotation of the genome. In this study, we designed a pipeline that can be used to assemble prokaryotic draft genomes with low number of contigs and high N50 value. We aimed to use combination of two de novo assembly tools (SPAdes and IDBA-Hybrid) and evaluate the impact of this approach on the quality metrics of the assemblies. The followed pipeline was tested with the raw sequence data with short reads (< 300) for a total of 10 species from four different genera. To obtain the final draft genomes, we firstly assembled the sequences using SPAdes to find closely related organism using the extracted 16 s rRNA from it. IDBA-Hybrid assembler was used to obtain the second assembly data using the closely related organism genome. SPAdes assembler tool was implemented using the second assembly, produced by IDBA-hybrid as a hint. The results were evaluated using QUAST and BUSCO. The pipeline was successful for the reduction of the contig numbers and increasing the N50 statistical values in the draft genome assemblies while preserving the coverage of the draft genomes.
During his trip to New Spain in 1803, Alexander von Humboldt visited large tracts of New Spanish territory, which includes modern Mexico and part of the United States. This trip provided the data for his geographical Atlas of the region, as well as information about the ancient Mexican cultures that he would later include in the general Atlas and in other major works, such as Vues des Cordillères. Likewise, Humboldt’s Political Essay on the Kingdom of New Spain displayed a comprehensive physical, natural, economic, and social description of Mexico in the colonial period, which will also be analysed. With these works, Humboldt presented a new geographical and cultural image of New Spain to the European audiences. In addition to this, his work made important contributions to cartographic knowledge.
Measures for interoperability of phenotypic data: minimum information requirements and formatting
(2016)
Background: Plant phenotypic data shrouds a wealth of information which, when accurately analysed and linked to other data types, brings to light the knowledge about the mechanisms of life. As phenotyping is a field of research comprising manifold, diverse and time-consuming experiments, the findings can be fostered by reusing and combining existing datasets. Their correct interpretation, and thus replicability, comparability and interoperability, is possible provided that the collected observations are equipped with an adequate set of metadata. So far there have been no common standards governing phenotypic data description, which hampered data exchange and reuse. Results: In this paper we propose the guidelines for proper handling of the information about plant phenotyping experiments, in terms of both the recommended content of the description and its formatting. We provide a document called "Minimum Information About a Plant Phenotyping Experiment", which specifies what information about each experiment should be given, and a Phenotyping Configuration for the ISA-Tab format, which allows to practically organise this information within a dataset. We provide examples of ISA-Tab-formatted phenotypic data, and a general description of a few systems where the recommendations have been implemented. Conclusions: Acceptance of the rules described in this paper by the plant phenotyping community will help to achieve findable, accessible, interoperable and reusable data.
Migration and development in Senegal : a system dynamics analysis of the feedback relationships
(2011)
This thesis investigates the reciprocal relationship between migration and development in Senegal. Therewith, it contributes to the debate as to whether migration in developing countries enhances or rather impedes the development process. Even though extensive and controversial discussions can be found in the scientific literature regarding the impact of migration on development, research has scarcely examined the feedback relationships between migration and development. Science however agrees with both the fact that migration affects development as well as that the level of development in a country determines migration behaviour. Thus, both variables are neither dependent nor independent, but endogenous variables influencing each other and producing behavioural pattern that cannot be investigated using a static and unidirectional approach. On account of this, the thesis studies the feedback mechanisms existing between migration and development and the behavioural pattern generated by the high interdependence in order to be able to draw conclusions concerning the impact of changes in migration behaviour on the development process. To explore these research questions, the study applies the computer simulation method ‘System Dynamics’ and amplifies the simulation model for national development planning called ‘Threshold 21’ (T21), representing development processes endogenously and integrating economic, social and environmental aspects, using a structure that portrays the reasons and consequences of migration. The model has been customised to Senegal, being an appropriate representative of the theoretical interesting universe of cases. The comparison of the model generated scenarios - in which the intensity of emigration, the loss and gain of education, the remittances or the level of dependence changes - facilitates the analysis. The present study produces two important results. The first outcome is the development of an integrative framework representing migration and development in an endogenous way and incorporating several aspects of different theories. This model can be used as a starting point for further discussions and improvements and it is a fairly relevant and useful result against the background that migration is not integrated into most of the development planning tools despite its significant impact. The second outcome is the gained insights concerning the feedback relations between migration and development and the impact of changes in migration on development. To give two examples: It could be found that migration impacts development positively, indicated by HDI, but that the dominant behaviour of migration and development is a counteracting behaviour. That means that an increase in emigration leads to an improvement in development, while this in turn causes a decline in emigration, counterbalancing the initial increase. Another insight concerns the discovery that migration causes a decline in education in the short term, but leads to an increase in the long term, after approximately 25 years - a typical worse-before-better behaviour. From these and further observations, important policy implications can be derived for the sending and receiving countries. Hence, by overcoming the unidirectional perspective, this study contributes to an improved understanding of the highly complex relationship between migration and development and their feedback relations.
The pressure dependence of sheath gas assisted electrospray ionization (ESI) was investigated based on two complementary experimental setups, namely an ESI-ion mobility (IM) spectrometer and an ESI capillary - Faraday plate setup housed in an optically accessible vacuum chamber. The ESI-IM spectrometer is capable of working in the pressure range between 300 and 1000 mbar. Another aim was the assessment of the analytical capabilities of a subambient pressure ESI-IM spectrometer. The pressure dependence of ESI was characterized by imaging the electrospray and recording current-voltage (I-U) curves. Qualitatively different behavior was observed in both setups. While the current rises continuously with the voltage in the capillary-plate setup, a sharp increase of the current was measured in the IM spectrometer above a pressure-dependent threshold voltage. The different character can be attributed to the detection of different species in both experiments. In the capillary-plate experiment, a multitude of charged species are detected while only desolvated ions attribute to the IM spectrometer signal. This finding demonstrates the utility of IM spectrometry for the characterization of ESI, since in contrast to the capillary-plate setup, the release of ions from the electrospray droplets can be observed. The I-U curves change significantly with pressure. An important result is the reduction of the maximum current with decreasing pressure. The connected loss of ionization efficiency can be compensated by a more efficient transfer of ions in the IM spectrometer at increased E/N. Thus, similar limits of detection could be obtained at 500 mbar and 1 bar.
The capability of electrospray ionization (ESI)-ion mobility (IM) spectrometry for reaction monitoring is assessed both as a stand-alone real-time technique and in combination with HPLC. A three-step chemical reaction, consisting of a Williamson ether synthesis followed by a hydrogenation and an N-alkylation step, is chosen for demonstration. Intermediates and products are determined with a drift time to mass-per-charge correlation. Addition of an HPLC column to the setup increases the separation power and allows the determination of further species. Monitoring of the intensities of the various species over the reaction time allows the detection of the end of reaction, determination of the rate-limiting step, observation of the system response in discontinuous processes, and optimization of the mass ratios of the starting materials. However, charge competition in ESI influences the quantitative detection of substances in the reaction mixture. Therefore, two different methods are investigated, which allow the quantification and investigation of reaction kinetics. The first method is based on the pre-separation of the compounds on an HPLC column and their subsequent individual detection in the ESI-IM spectrometer. The second method involves an extended calibration procedure, which considers charge competition effects and facilitates nearly real-time quantification.
The application of electrospray ionization (ESI) ion mobility (IM) spectrometry on the detection end of a high-performance liquid chromatograph has been a subject of study for some time. So far, this method has been limited to low flow rates or has required splitting of the liquid flow. This work presents a novel concept of an ESI source facilitating the stable operation of the spectrometer at flow rates between 10 mu L min(-1) and 1500 mu L min(-1) without flow splitting, advancing the T-cylinder design developed by Kurnin and co-workers. Flow rates eight times faster than previously reported were achieved because of a more efficient dispersion of the liquid at increased electrospray voltages combined with nebulization by a sheath gas. Imaging revealed the spray operation to be in a rotationally symmetric multijet-mode. The novel ESI-IM spectrometer tolerates high water contents (<= 90%) and electrolyte concentrations up to 10 mM, meeting another condition required of high-performance liquid chromatography (HPLC) detectors. Limits of detection of 50 nM for promazine in the positive mode and 1 mu M for 1,3-dinitrobenzene in the negative mode were established. Three mixtures of reduced complexity (five surfactants, four neuroleptics, and two isomers) were separated in the millisecond regime in stand-alone operation of the spectrometer. Separations of two more complex mixtures (five neuroleptics and 13 pesticides) demonstrate the application of the spectrometer as an HPLC detector. The examples illustrate the advantages of the spectrometer over the established diode array detector, in terms of additional IM separation of substances not fully separated in the retention time domain as well as identification of substances based on their characteristic IMs.
The combination of high-performance liquid chromatography and electrospray ionization ion mobility spectrometry facilitates the two-dimensional separation of complex mixtures in the retention and drift time plane. The ion mobility spectrometer presented here was optimized for flow rates customarily used in high-performance liquid chromatography between 100 and 1500 mu L/min. The characterization of the system with respect to such parameters as the peak capacity of each time dimension and of the 2D spectrum was carried out based on a separation of a pesticide mixture containing 24 substances. While the total ion current chromatogram is coarsely resolved, exhibiting coelutions for a number of compounds, all substances can be separately detected in the 2D plane due to the orthogonality of the separations in retention and drift dimensions. Another major advantage of the ion mobility detector is the identification of substances based on their characteristic mobilities. Electrospray ionization allows the detection of substances lacking a chromophore. As an example, the separation of a mixture of 18 amino acids is presented. A software built upon the free mass spectrometry package OpenMS was developed for processing the extensive 2D data. The different processing steps are implemented as separate modules which can be arranged in a graphic workflow facilitating automated processing of data.
The increasing development of antibiotic resistance in bacteria has been a major problem for years, both in human and veterinary medicine. Prophylactic measures, such as the use of vaccines, are of great importance in reducing the use of antibiotics in livestock. These vaccines are mainly produced based on formaldehyde inactivation. However, the latter damages the recognition elements of the bacterial proteins and thus could reduce the immune response in the animal. An alternative inactivation method developed in this work is based on gentle photodynamic inactivation using carbon nanodots (CNDs) at excitation wavelengths λex > 290 nm. The photodynamic inactivation was characterized on the nonvirulent laboratory strain Escherichia coli K12 using synthesized CNDs. For a gentle inactivation, the CNDs must be absorbed into the cytoplasm of the E. coli cell. Thus, the inactivation through photoinduced formation of reactive oxygen species only takes place inside the bacterium, which means that the outer membrane is neither damaged nor altered. The loading of the CNDs into E. coli was examined using fluorescence microscopy. Complete loading of the bacterial cells could be achieved in less than 10 min. These studies revealed a reversible uptake process allowing the recovery and reuse of the CNDs after irradiation and before the administration of the vaccine. The success of photodynamic inactivation was verified by viability assays on agar. In a homemade flow photoreactor, the fastest successful irradiation of the bacteria could be carried out in 34 s. Therefore, the photodynamic inactivation based on CNDs is very effective. The membrane integrity of the bacteria after irradiation was verified by slide agglutination and atomic force microscopy. The method developed for the laboratory strain E. coli K12 could then be successfully applied to the important avian pathogens Bordetella avium and Ornithobacterium rhinotracheale to aid the development of novel vaccines.
The increasing development of antibiotic resistance in bacteria has been a major problem for years, both in human and veterinary medicine. Prophylactic measures, such as the use of vaccines, are of great importance in reducing the use of antibiotics in livestock. These vaccines are mainly produced based on formaldehyde inactivation. However, the latter damages the recognition elements of the bacterial proteins and thus could reduce the immune response in the animal. An alternative inactivation method developed in this work is based on gentle photodynamic inactivation using carbon nanodots (CNDs) at excitation wavelengths λex > 290 nm. The photodynamic inactivation was characterized on the nonvirulent laboratory strain Escherichia coli K12 using synthesized CNDs. For a gentle inactivation, the CNDs must be absorbed into the cytoplasm of the E. coli cell. Thus, the inactivation through photoinduced formation of reactive oxygen species only takes place inside the bacterium, which means that the outer membrane is neither damaged nor altered. The loading of the CNDs into E. coli was examined using fluorescence microscopy. Complete loading of the bacterial cells could be achieved in less than 10 min. These studies revealed a reversible uptake process allowing the recovery and reuse of the CNDs after irradiation and before the administration of the vaccine. The success of photodynamic inactivation was verified by viability assays on agar. In a homemade flow photoreactor, the fastest successful irradiation of the bacteria could be carried out in 34 s. Therefore, the photodynamic inactivation based on CNDs is very effective. The membrane integrity of the bacteria after irradiation was verified by slide agglutination and atomic force microscopy. The method developed for the laboratory strain E. coli K12 could then be successfully applied to the important avian pathogens Bordetella avium and Ornithobacterium rhinotracheale to aid the development of novel vaccines.
The knowledge of the largest expected earthquake magnitude in a region is one of the key issues in probabilistic seismic hazard calculations and the estimation of worst-case scenarios. Earthquake catalogues are the most informative source of information for the inference of earthquake magnitudes. We analysed the earthquake catalogue for Central Asia with respect to the largest expected magnitudes m(T) in a pre-defined time horizon T-f using a recently developed statistical methodology, extended by the explicit probabilistic consideration of magnitude errors. For this aim, we assumed broad error distributions for historical events, whereas the magnitudes of recently recorded instrumental earthquakes had smaller errors. The results indicate high probabilities for the occurrence of large events (M >= 8), even in short time intervals of a few decades. The expected magnitudes relative to the assumed maximum possible magnitude are generally higher for intermediate-depth earthquakes (51-300 km) than for shallow events (0-50 km). For long future time horizons, for example, a few hundred years, earthquakes with M >= 8.5 have to be taken into account, although, apart from the 1889 Chilik earthquake, it is probable that no such event occurred during the observation period of the catalogue.
Earthquake catalogs are probably the most informative data source about spatiotemporal seismicity evolution. The catalog quality in one of the most active seismogenic zones in the world, Japan, is excellent, although changes in quality arising, for example, from an evolving network are clearly present. Here, we seek the best estimate for the largest expected earthquake in a given future time interval from a combination of historic and instrumental earthquake catalogs. We extend the technique introduced by Zoller et al. (2013) to estimate the maximum magnitude in a time window of length T-f for earthquake catalogs with varying level of completeness. In particular, we consider the case in which two types of catalogs are available: a historic catalog and an instrumental catalog. This leads to competing interests with respect to the estimation of the two parameters from the Gutenberg-Richter law, the b-value and the event rate lambda above a given lower-magnitude threshold (the a-value). The b-value is estimated most precisely from the frequently occurring small earthquakes; however, the tendency of small events to cluster in aftershocks, swarms, etc. violates the assumption of a Poisson process that is used for the estimation of lambda. We suggest addressing conflict by estimating b solely from instrumental seismicity and using large magnitude events from historic catalogs for the earthquake rate estimation. Applying the method to Japan, there is a probability of about 20% that the maximum expected magnitude during any future time interval of length T-f = 30 years is m >= 9.0. Studies of different subregions in Japan indicates high probabilities for M 8 earthquakes along the Tohoku arc and relatively low probabilities in the Tokai, Tonankai, and Nankai region. Finally, for scenarios related to long-time horizons and high-confidence levels, the maximum expected magnitude will be around 10.
We show how the maximum magnitude within a predefined future time horizon may be estimated from an earthquake catalog within the context of Gutenberg-Richter statistics. The aim is to carry out a rigorous uncertainty assessment, and calculate precise confidence intervals based on an imposed level of confidence a. In detail, we present a model for the estimation of the maximum magnitude to occur in a time interval T-f in the future, given a complete earthquake catalog for a time period T in the past and, if available, paleoseismic events. For this goal, we solely assume that earthquakes follow a stationary Poisson process in time with unknown productivity Lambda and obey the Gutenberg-Richter law in magnitude domain with unknown b-value. The random variables. and b are estimated by means of Bayes theorem with noninformative prior distributions. Results based on synthetic catalogs and on retrospective calculations of historic catalogs from the highly active area of Japan and the low-seismicity, but high-risk region lower Rhine embayment (LRE) in Germany indicate that the estimated magnitudes are close to the true values. Finally, we discuss whether the techniques can be extended to meet the safety requirements for critical facilities such as nuclear power plants. For this aim, the maximum magnitude for all times has to be considered. In agreement with earlier work, we find that this parameter is not a useful quantity from the viewpoint of statistical inference.
The injection of fluids is a well-known origin for the triggering of earthquake sequences. The growing number of projects related to enhanced geothermal systems, fracking, and others has led to the question, which maximum earthquake magnitude can be expected as a consequence of fluid injection? This question is addressed from the perspective of statistical analysis. Using basic empirical laws of earthquake statistics, we estimate the magnitude M-T of the maximum expected earthquake in a predefined future time window T-f. A case study of the fluid injection site at Paradox Valley, Colorado, demonstrates that the magnitude m 4.3 of the largest observed earthquake on 27 May 2000 lies very well within the expectation from past seismicity without adjusting any parameters. Vice versa, for a given maximum tolerable earthquake at an injection site, we can constrain the corresponding amount of injected fluids that must not be exceeded within predefined confidence bounds.
The Groningen gas field serves as a natural laboratory for production-induced earthquakes, because no earthquakes were observed before the beginning of gas production. Increasing gas production rates resulted in growing earthquake activity and eventually in the occurrence of the 2012M(w) 3.6 Huizinge earthquake. At least since this event, a detailed seismic hazard and risk assessment including estimation of the maximum earthquake magnitude is considered to be necessary to decide on the future gas production. In this short note, we first apply state-of-the-art methods of mathematical statistics to derive confidence intervals for the maximum possible earthquake magnitude m(max). Second, we calculate the maximum expected magnitude M-T in the time between 2016 and 2024 for three assumed gas-production scenarios. Using broadly accepted physical assumptions and 90% confidence level, we suggest a value of m(max) 4.4, whereas M-T varies between 3.9 and 4.3, depending on the production scenario.