Refine
Year of publication
- 2023 (1221) (remove)
Document Type
- Article (542)
- Doctoral Thesis (275)
- Part of a Book (146)
- Monograph/Edited Volume (80)
- Postprint (35)
- Review (31)
- Working Paper (21)
- Part of Periodical (16)
- Conference Proceeding (15)
- Master's Thesis (13)
Keywords
- digital education (35)
- e-learning (34)
- Digitale Bildung (32)
- Kursdesign (32)
- MOOC (32)
- Micro Degree (32)
- Online-Lehre (32)
- Onlinekurs (32)
- Onlinekurs-Produktion (32)
- micro degree (32)
Institute
- Extern (189)
- Bürgerliches Recht (95)
- Fachgruppe Politik- & Verwaltungswissenschaft (95)
- Historisches Institut (94)
- Fachgruppe Betriebswirtschaftslehre (81)
- Zentrum für Lehrerbildung und Bildungsforschung (ZeLB) (74)
- Institut für Biochemie und Biologie (69)
- Hasso-Plattner-Institut für Digital Engineering GmbH (60)
- Strafrecht (53)
- Institut für Physik und Astronomie (40)
Das Dokument "Forschungsdatenmanagement bei personenbezogenen Daten - eine Handreichung" versammelt zentrale Inhalte, Verweise und Vorgehensweisen für Forscher*innen, die in einer Studie personenbezogene Daten erheben und diese verarbeiten, archivieren oder veröffentlichen wollen. Die Handreichung verweist an den entsprechenden Abschnitten auf weiterführende Materialien wie insbesondere die Handreichung „Datenschutz“ des Rats für die Sozial-, Verhaltens-, Bildungs- und Wirtschaftswissenschaften (RatSWD).
Sulfur is an important element that is incorporated into many biomolecules in humans. The incorporation and transfer of sulfur into biomolecules is, however, facilitated by a series of different sulfurtransferases. Among these sulfurtransferases is the human mercaptopyruvate sulfurtransferase (MPST) also designated as tRNA thiouridine modification protein (TUM1). The role of the human TUM1 protein has been suggested in a wide range of physiological processes in the cell among which are but not limited to involvement in Molybdenum cofactor (Moco) biosynthesis, cytosolic tRNA thiolation and generation of H2S as signaling molecule both in mitochondria and the cytosol. Previous interaction studies showed that TUM1 interacts with the L-cysteine desulfurase NFS1 and the Molybdenum cofactor biosynthesis protein 3 (MOCS3). Here, we show the roles of TUM1 in human cells using CRISPR/Cas9 genetically modified Human Embryonic Kidney cells. Here, we show that TUM1 is involved in the sulfur transfer for Molybdenum cofactor synthesis and tRNA thiomodification by spectrophotometric measurement of the activity of sulfite oxidase and liquid chromatography quantification of the level of sulfur-modified tRNA. Further, we show that TUM1 has a role in hydrogen sulfide production and cellular bioenergetics.
In late summer, migratory bats of the temperate zone face the challenge of accomplishing two energy-demanding tasks almost at the same time: migration and mating. Both require information and involve search efforts, such as localizing prey or finding potential mates. In non-migrating bat species, playback studies showed that listening to vocalizations of other bats, both con-and heterospecifics, may help a recipient bat to find foraging patches and mating sites. However, we are still unaware of the degree to which migrating bats depend on con-or heterospecific vocalizations for identifying potential feeding or mating opportunities during nightly transit flights. Here, we investigated the vocal responses of Nathusius’ pipistrelle bats, Pipistrellus nathusii, to simulated feeding and courtship aggregations at a coastal migration corridor. We presented migrating bats either feeding buzzes or courtship calls of their own or a heterospecific migratory species, the common noctule, Nyctalus noctula. We expected that during migratory transit flights, simulated feeding opportunities would be particularly attractive to bats, as well as simulated mating opportunities which may indicate suitable roosts for a stopover. However, we found that when compared to the natural silence of both pre-and post-playback phases, bats called indifferently during the playback of conspecific feeding sounds, whereas P. nathusii echolocation call activity increased during simulated feeding of N. noctula. In contrast, the call activity of P. nathusii decreased during the playback of conspecific courtship calls, while no response could be detected when heterospecific call types were broadcasted. Our results suggest that while on migratory transits, P. nathusii circumnavigate conspecific mating aggregations, possibly to save time or to reduce the risks associated with social interactions where aggression due to territoriality might be expected. This avoidance behavior could be a result of optimization strategies by P. nathusii when performing long-distance migratory flights, and it could also explain the lack of a response to simulated conspecific feeding. However, the observed increase of activity in response to simulated feeding of N. noctula, suggests that P. nathusii individuals may be eavesdropping on other aerial hawking insectivorous species during migration, especially if these occupy a slightly different foraging niche.
Obwohl Bildungsreisen nach England und in andere westeuropäische Staaten in adligen Kreisen seinerzeit regelrecht in Mode waren, ragen die Itzenplitz'schen Briefe aufgrund ihrer inhaltlichen Vielseitigkeit sowie wegen des häufigen Auftretens der bedeutendsten englischen Agrarökonomen und Naturwissenschaftler jener Zeit aus vergleichbaren Überlieferungen heraus.Henriette und Peter von Itzenplitz - erstere war die Tochter der vor allem durch Theodor Fontanes »Wanderungen...« bekannt gewordenen Agrarpionierin »Frau von Friedland« auf Kunersdorf im Oderbruch - traten kurz nach ihrer Hochzeit im Herbst 1792 eine landwirtschaftlich-ökonomisch-botanische Bildungsreise nach England an. Sie starteten vom Itzenplitz'schen Familiengut im havelländischen Groß Behnitz aus und sollten über ein Jahr lang unterwegs sein. Erst am letzten Tag des Jahres 1793 kehrte das junge Ehepaar mit ihrem in Kew bei London geborenen Sohn abgekämpft, aber erfüllt heim.Die von den beiden unterwegs regelmäßig an...
Chronologie der Englandreise
(2023)
Einleitender Kommentar
(2023)
Digitale Reflexionsanlässe
(2023)
Geschichts-Didaktik
(2023)
Its properties make copper one of the world’s most important functional metals. Numerous megatrends are increasing the demand for copper. This requires the prospection and exploration of new deposits, as well as the monitoring of copper quality in the various production steps. A promising technique to perform these tasks is Laser Induced Breakdown Spectroscopy (LIBS). Its unique feature, among others, is the ability to measure on site without sample collection and preparation. In this work, copper-bearing minerals from two different deposits are studied. The first set of field samples come from a volcanogenic massive sulfide (VMS) deposit, the second part from a stratiform sedimentary copper (SSC) deposit. Different approaches are used to analyze the data. First, univariate regression (UVR) is used. However, due to the strong influence of matrix effects, this is not suitable for the quantitative analysis of copper grades. Second, the multivariate method of partial least squares regression (PLSR) is used, which is more suitable for quantification. In addition, the effects of the surrounding matrices on the LIBS data are characterized by principal component analysis (PCA), alternative regression methods to PLSR are tested and the PLSR calibration is validated using field samples.
Das Eigene und das Fremde
(2023)
Die vorliegende Arbeit stellt eine Untersuchung des Fremdverstehens von Lehrkräften im Mathematikunterricht dar. Mit ‚Fremdverstehen‘ soll dabei – in Anlehnung an den Soziologen Alfred Schütz – der Prozess bezeichnet werden, in welchem eine Lehrkraft versucht, das Verhalten einer Schülerin oder eines Schülers zu verstehen, indem sie dieses Verhalten auf ein Erleben zurückführt, das ihm zugrunde gelegen haben könnte. Als ein wesentliches Merkmal des Prozesses stellt Schütz in seiner Theorie des Fremdverstehens heraus, dass das Fremdverstehen eines Menschen immer auch auf seinen eigenen Erlebnissen basiert. Aus diesem Grund wird in der Arbeit ein methodischer Zweischritt vorgenommen: Es werden zunächst die mathematikbezogenen Erlebnisse zweier Lehrkräfte nachgezeichnet, bevor dann ihr Fremdverstehen in konkreten Situationen im Mathematikunterricht rekonstruiert wird. In der ersten Teiluntersuchung (= der Rekonstruktion eigener Erlebnisse der untersuchten Lehrkräfte) erfolgt die Datenerhebung mit Hilfe biographisch-narrativer Interviews, in denen die untersuchten Lehrkräfte angeregt werden, ihre mathematikbezogene Lebensgeschichte zu erzählen. Die Analyse dieser Interviews wird im Sinne der rekonstruktiven Fallanalyse vorgenommen. Insgesamt führt die erste Teiluntersuchung zu textlichen Darstellungen der rekonstruierten mathematikbezogenen Lebensgeschichte der untersuchten Mathematiklehrkräfte. In der zweiten Teiluntersuchung (= der Rekonstruktion des Fremdverstehens der untersuchten Lehrkräfte) werden dann narrative Interviews geführt, in denen die untersuchten Lehrkräfte von ihrem Fremdverstehen in konkreten Situationen im Mathematikunterricht erzählen. Die Analyse dieser Interviews erfolgt mit Hilfe eines dreischrittigen Analyseverfahrens, welches die Autorin eigens zum Zweck der Rekonstruktion von Fremdverstehen entwickelte. Am Ende dieser zweiten Teiluntersuchung werden sowohl das rekonstruierte Fremdverstehen der Lehrkräfte in verschiedenen Unterrichtssituationen dargestellt als auch Strukturen, die sich in ihrem Fremdverstehen abzeichnen. Mit Hilfe einer theoretischen Verallgemeinerung werden schließlich – auf Basis der Ergebnisse der zweiten Teiluntersuchung – Aussagen über fünf Merkmale des Fremdverstehens von Lehrkräften im Mathematikunterricht im Allgemeinen gewonnen. Mit diesen Aussagen vermag die Arbeit eine erste Beschreibung davon hervorzubringen, wie sich das Phänomen des Fremdverstehens von Lehrkräften im Mathematikunterricht ausgestalten kann.
The African weakly electric fish genus Campylomormyrus includes 15 described species mostly native to the Congo River and its tributaries. They are considered sympatric species, because their distribution area overlaps. These species generate species-specific electric organ discharges (EODs) varying in waveform characteristics, including duration, polarity, and phase number. They exhibit also pronounced divergence in their snout, i.e. the length, thickness, and curvature. The diversifications in these two phenotypical traits (EOD and snout) have been proposed as key factors promoting adaptive radiation in Campylomormyrus. The role of EODs as a pre-zygotic isolation mechanism driving sympatric speciation by promoting assortative mating has been examined using behavioral, genetical, and histological approaches. However, the evolutionary effects of the snout morphology and its link to species divergence have not been closely examined. Hence, the main objective of this study is to investigate the effect of snout morphology diversification and its correlated EOD to better understand their sympatric speciation and evolutionary drivers. Moreover, I aim to utilize the intragenus and intergenus hybrids of Campylomormyrus to better understand trait divergence as well as underlying molecular/genetic mechanisms involved in the radiation scenario. To this end, I utilized three different approaches: feeding behavior analysis, diet assessment, and geometric morphometrics analysis. I performed feeding behavior experiments to evaluate the concept of the phenotype-environment correlation by testing whether Campylomormyrus species show substrate preferences. The behavioral experiments showed that the short snout species exhibits preference to sandy substrate, the long snout species prefers a stone substrate, and the species with intermediate snout size does not exhibit any substrate preference. The experiments suggest that the diverse feeding apparatus in the genus Campylomormyrus may have evolved in adaptation to their microhabitats. I also performed diet assessments of sympatric Campylomormyrus species and a sister genus species (Gnathonemus petersii) with markedly different snout morphologies and EOD using NGS-based DNA metabarcoding of their stomach contents. The diet of each species was documented showing that aquatic insects such as dipterans, coleopterans and trichopterans represent the major diet component. The results showed also that all species are able to exploit diverse food niches in their habitats. However, comparing the diet overlap indices showed that different snout morphologies and the associated divergence in the EOD translated into different prey spectra. These results further support the idea that the EOD could be a ‘magic trait’ triggering both adaptation and reproductive isolation. Geometric morphometrics method was also used to compare the phenotypical shape traits of the F1 intragenus (Campylomormyrus) and intergenus (Campylomormyrus species and Gnathonemus petersii) hybrids relative to their parents. The hybrids of these species were well separated based on the morphological traits, however the hybrid phenotypic traits were closer to the short-snouted species. In addition, the likelihood that the short snout expressed in the hybrids increases with increasing the genetic distance of the parental species. The results confirmed that additive effects produce intermediate phenotypes in F1-hybrids. It seems, therefore, that morphological shape traits in hybrids, unlike the physiological traits, were not expressed straightforward.
Das Spannungsverhältnis zwischen Meinungsfreiheit und allgemeinem Persönlichkeitsrecht hat das Bundesverfassungsgericht seit Jahrzehnten und wiederholt beschäftigt. Insbesondere in den letzten drei Jahren hatte sich das Gericht erneut intensiv damit zu befassen, einen angemessenen Ausgleich zwischen den sich gegenüberstehenden Grundrechtspositionen zu formulieren. Der Beitrag analysiert überblicksartig, inwieweit es in seinen neueren Entscheidungen seine bisherige Rechtsprechung fortgeführt, ergänzt oder gar nachjustiert hat.
The chapter describes the German procedure for obtaining compensation for wrongful convictions. Besides specific cases of compensation for convictions based on subsequently repealed legislation and claims arising from general official liability, German law provides a mechanism for compensation, insofar as a conviction is eliminated or mitigated in a retrial in criminal proceedings. Still within this retrial, the criminal court is called upon to determine whether a claim exists for compensation of material and/or non-material damages on the merits. The amount of compensation is assessed in a judicial administrative procedure at the request of the person concerned. The compensation for non-material harm is calculated on the basis of a lump sum of currently €75 per day of imprisonment; the extent of material harm must be submitted and proven by the person concerned. She has the right to take legal action in the civil courts against the decision on the amount, she has the right to take legal action in the civil courts.
§§ 253-299a
(2023)
Die Kommentierung umfasst neben der Zivilprozessordnung auch die relevanten Nebengesetze (wie EGZPO, GVG, KapMuG und MediationsG) sowie das europäische und internationale Zivilprozessrecht. Selbstverständlich sind alle relevanten Gesetzesänderungen sowie die neuesten Entwicklungen in Rechtsprechung und Lehre berücksichtigt.
Umfassende Kommentierung zum Verfahren vor den Landgerichten bis zum Urteil.
Networking fast and slow
(2023)
Growing interest in network dynamics has led to insights about patterns of network change, drivers of tie formation, and the temporal unfolding of the consequences of networks. To this area of inquiry, we introduce networking speed—the time that it takes for individuals to form a network tie—as an important but so far largely overlooked aspect. We develop a theory of networking speed that explains how different catalysts enable professionals to introduce variation into the speed with which they form interpersonal network ties. We discuss how such variation in the speed with which ties have been formed influences relational outcomes and the network returns that these ties generate. This discussion illustrates that high networking speed can entail advantages as well as pitfalls. We also explore temporal implications of networking speed—for instance, the persistence of the effects of speed over time. Overall, we conceptualize networking speed as a constitutive element of how interpersonal networks function in professional settings, and we propose a future research program for the integration of this novel concept into organizational network research.
Digitalization, as well as sustainability, are gaining increased relevance and have attracted significant attention in research and practice. However, the research already published about this topic examining digitalization in the retail sector does not consider the acceptance of related innovations, nor their impact on sustainability. Therefore, this article critically analyzes the acceptance of customers towards digital technologies in fashion stores as well as their impact on sustainability in the textile industry. The comprehensive analysis of the literature and the current state of research provide the basis of this paper. Theoretical models, such as the Technology-Acceptance-Model (TAM) and the Unified Theory of Acceptance and Use of Technology 2 (UTAUT 2) enable the evaluation of expectations and acceptance, as well as the assessment of possible inhibitory factors for the subsequent descriptive and statistical examination of the acceptance of digital technologies in fashion stores. The research on this subject was examined in a quantitative way. The key findings show that customers do accept digital technologies in fashion stores. The final part of this contribution describes the innovative Digitalization 4 Sustainability Framework which shows that digital technologies at the point of sale (PoS) in fashion stores could have a positive impact on sustainability. Overall, this paper shows that it is particularly important for fashion stores to concentrate on their individual strengths and customer needs as well as to indicate a more sustainable way by using digital technologies, in order to achieve added value for the customers and to set themselves apart from the competition while designing a more sustainable future. Moreover, fashion stores should make it a point of their honor to harness the power of digitalization for sake of sustainability and economic value creation.
Achilles tendinopathy (AT) is a debilitating injury in athletes, especially for those engaged in repetitive stretch-shortening cycle activities. Clinical risk factors are numerous, but it has been suggested that altered biomechanics might be associated with AT. No systematic review has been conducted investigating these biomechanical alterations in specifically athletic populations. Therefore, the aim of this systematic review was to compare the lower-limb biomechanics of athletes with AT to athletically matched asymptomatic controls. Databases were searched for relevant studies investigating biomechanics during gait activities and other motor tasks such as hopping, isolated strength tasks, and reflex responses. Inclusion criteria for studies were an AT diagnosis in at least one group, cross-sectional or prospective data, at least one outcome comparing biomechanical data between an AT and healthy group, and athletic populations. Studies were excluded if patients had Achilles tendon rupture/surgery, participants reported injuries other than AT, and when only within-subject data was available.. Effect sizes (Cohen's d) with 95% confidence intervals were calculated for relevant outcomes. The initial search yielded 4,442 studies. After screening, twenty studies (775 total participants) were synthesised, reporting on a wide range of biomechanical outcomes. Females were under-represented and patients in the AT group were three years older on average. Biomechanical alterations were identified in some studies during running, hopping, jumping, strength tasks and reflex activity. Equally, several biomechanical variables studied were not associated with AT in included studies, indicating a conflicting picture. Kinematics in AT patients appeared to be altered in the lower limb, potentially indicating a pattern of “medial collapse”. Muscular activity of the calf and hips was different between groups, whereby AT patients exhibited greater calf electromyographic amplitudes despite lower plantar flexor strength. Overall, dynamic maximal strength of the plantar flexors, and isometric strength of the hips might be reduced in the AT group. This systematic review reports on several biomechanical alterations in athletes with AT. With further research, these factors could potentially form treatment targets for clinicians, although clinical approaches should take other contributing health factors into account. The studies included were of low quality, and currently no solid conclusions can be drawn.
Achilles tendinopathy (AT) is a debilitating injury in athletes, especially for those engaged in repetitive stretch-shortening cycle activities. Clinical risk factors are numerous, but it has been suggested that altered biomechanics might be associated with AT. No systematic review has been conducted investigating these biomechanical alterations in specifically athletic populations. Therefore, the aim of this systematic review was to compare the lower-limb biomechanics of athletes with AT to athletically matched asymptomatic controls. Databases were searched for relevant studies investigating biomechanics during gait activities and other motor tasks such as hopping, isolated strength tasks, and reflex responses. Inclusion criteria for studies were an AT diagnosis in at least one group, cross-sectional or prospective data, at least one outcome comparing biomechanical data between an AT and healthy group, and athletic populations. Studies were excluded if patients had Achilles tendon rupture/surgery, participants reported injuries other than AT, and when only within-subject data was available.. Effect sizes (Cohen's d) with 95% confidence intervals were calculated for relevant outcomes. The initial search yielded 4,442 studies. After screening, twenty studies (775 total participants) were synthesised, reporting on a wide range of biomechanical outcomes. Females were under-represented and patients in the AT group were three years older on average. Biomechanical alterations were identified in some studies during running, hopping, jumping, strength tasks and reflex activity. Equally, several biomechanical variables studied were not associated with AT in included studies, indicating a conflicting picture. Kinematics in AT patients appeared to be altered in the lower limb, potentially indicating a pattern of “medial collapse”. Muscular activity of the calf and hips was different between groups, whereby AT patients exhibited greater calf electromyographic amplitudes despite lower plantar flexor strength. Overall, dynamic maximal strength of the plantar flexors, and isometric strength of the hips might be reduced in the AT group. This systematic review reports on several biomechanical alterations in athletes with AT. With further research, these factors could potentially form treatment targets for clinicians, although clinical approaches should take other contributing health factors into account. The studies included were of low quality, and currently no solid conclusions can be drawn.
Ribosomes decode mRNA to synthesize proteins. Ribosomes, once considered static, executing machines, are now viewed as dynamic modulators of translation. Increasingly detailed analyses of structural ribosome heterogeneity led to a paradigm shift toward ribosome specialization for selective translation. As sessile organisms, plants cannot escape harmful environments and evolved strategies to withstand. Plant cytosolic ribosomes are in some respects more diverse than those of other metazoans. This diversity may contribute to plant stress acclimation. The goal of this thesis was to determine whether plants use ribosome heterogeneity to regulate protein synthesis through specialized translation. I focused on temperature acclimation, specifically on shifts to low temperatures. During cold acclimation, Arabidopsis ceases growth for seven days while establishing the responses required to resume growth. Earlier results indicate that ribosome biogenesis is essential for cold acclimation. REIL mutants (reil-dkos) lacking a 60S maturation factor do not acclimate successfully and do not resume growth. Using these genotypes, I ascribed cold-induced defects of ribosome biogenesis to the assembly of the polypeptide exit tunnel (PET) by performing spatial statistics of rProtein changes mapped onto the plant 80S structure. I discovered that growth cessation and PET remodeling also occurs in barley, suggesting a general cold response in plants. Cold triggered PET remodeling is consistent with the function of Rei-1, a REIL homolog of yeast, which performs PET quality control. Using seminal data of ribosome specialization, I show that yeast remodels the tRNA entry site of ribosomes upon change of carbon sources and demonstrate that spatially constrained remodeling of ribosomes in metazoans may modulate protein synthesis. I argue that regional remodeling may be a form of ribosome specialization and show that heterogeneous cytosolic polysomes accumulate after cold acclimation, leading to shifts in the translational output that differs between wild-type and reil-dkos. I found that heterogeneous complexes consist of newly synthesized and reused proteins. I propose that tailored ribosome complexes enable free 60S subunits to select specific 48S initiation complexes for translation. Cold acclimated ribosomes through ribosome remodeling synthesize a novel proteome consistent with known mechanisms of cold acclimation. The main hypothesis arising from my thesis is that heterogeneous/ specialized ribosomes alter translation preferences, adjust the proteome and thereby activate plant programs for successful cold acclimation.
The Tetrarchy as Ideology
(2023)
In this paper, we show how socialist planning can be based on input-output data. We argue that the information required for this can be obtained by a central planning agency and thus dismiss Hayek’s information argument against socialism. We further show how economic planning can be made responsive to consumer demand through a feedback control mechanism. Output targets of products would be adjusted in response to observed consumer demand or based on predictions about future demand. Planners can use machine learning to make more accurate forecasts. The valuation of goods plays an important role in the feedback control mechanism. The values of goods can either be measured by the labour time necessary for their production (labour values) or through shadow prices based on linear programming.
Anchored in ink
(2023)
This book serves as a gateway to the Elementa grammaticae Huronicae, an eighteenth-century grammar of the Wendat (‘Huron’) language by Jesuit Pierre-Philippe Potier (1708–1781). The volume falls into three main parts. The first part introduces the grammar and some of its contexts, offering information about the Huron-Wendat and Wyandot, the early modern Jesuit mission in New France and the Jesuits’ linguistic output. The heart of the volume is made up by its second part, a text edition of the Elementa. The third part presents some avenues of research by way of specific case studies.
Der generelle Prozess der Digitalisierung ist für die Medienordnung von besonderer Relevanz. Stehen auf der einen Seite wichtige Kommunikations- und Effektivitätsgewinne, so müssen auf der anderen Seite gesellschaftliche Gefahren durch Hatespeech, Fake News oder Urheberrechtsverletzungen erkannt und verhindert werden. Der vorliegende Band enthält die Vorträge, die auf der 1. Berlin-Potsdamer Konferenz zu interdisziplinären Rechtsfragen im März 2022 in Berlin gehalten wurden. Sie beleuchten die aus der Medienkonvergenz folgenden Veränderungen der Medienlandschaft in zentralen Bereichen wie der Bekämpfung von Desinformation, der Digitalwirtschaft, der Wissenskommunikation, dem Persönlichkeitsrechtsschutz, dem Influencer-Marketing, der Plattformregulierung, der Musikwirtschaft und der Anonymität in sozialen Netzwerken. Dabei geht es jeweils auch um Empfehlungen, welche politischen Aktivitäten erforderlich sind, um die Digitalisierung einerseits zu fördern, andererseits aber auch ihren Gefahren wirksam zu begegnen.
The Media Privilege under Data Protection Law: Journalism and data protection are fundamentally at odds with each other. In view of current developments, the need for a functioning regulatory concept for both legal positions is probably more important than ever. This conceptual balance is provided by the journalistic exemption in data protection law. The thesis focuses on the scope of the exception. It also identifies existing coherence problems between European and national law.
Investment control has experienced a considerable increase in importance in M&A transactions, as it has been constantly adapted to real economic conditions and successively tightened. The result is a partially inconsistent review regime that contains value contradictions and creates legal uncertainties. In a comprehensive approach, this doctoral thesis analyzes the problems of the current investment control regime and states concrete reform proposals.
FRAKIS (Fragebogen zur frühkindlichen Sprachentwicklung) ist ein Elternfragenbogen zur Erfassung des Sprachstandes bei deutsch-sprachigen Kindern zwischen 18 und 30 Monaten und die deutsche Adaptation des MacArthur-Bates Communicative Development Inventory for Toddlers. Es gibt eine Langform (FRAKIS) und Kurzform (FRAKIS-K). Der lange Fragebogen enthält eine Wortliste von 600 Wörtern und Skalen zur Flexionsmorphologie und Syntax, die Kurzform eine Wortschatzliste von 102 Wörtern und drei Fragen zur Grammatik. Beide Fragebögen sind an einer Stichprobe von 1240 Kindern normiert. Die Normierungsstudie wird im Manual dargestellt. Normen werden in monatlichen Altersgruppen für Mädchen und Jungen getrennt, und für alle Kinder angegeben. Mit FRAKIS und FRAKIS-K stehen im deutschsprachigen Bereich erstmals Elternfragebögen zur Verfügung, die auf empirisch gesicherten, strengen Normierungsverfahren beruhen. Die Normwerte bringen ein Bezugssystem für das Ausmaß an Variabilität im frühen Spracherwerb. FRAKIS-K ist geeignet für die Sprachstandsbestimmung im Rahmen der kinderärztlichen Vorsorgeuntersuchungen. Kinder mit spätem oder verzögertem Sprachbeginn können identifiziert werden. Darüber hinaus sind die Fragebögen geeignet für eine Verlaufsbeobachtung der frühen Sprachentwicklung, ob in Forschung oder Praxis.
The role of biogenic carbonate producers in the evolution of the geometries of carbonate systems has been the subject of numerous research projects. Attempts to classify modern and ancient carbonate systems by their biotic components have led to the discrimination of biogenic carbonate producers broadly into Photozoans, which are characterised by an affinity for warm tropical waters and high dependence on light penetration, and Heterozoans which are generally associated with both cool water environments and nutrient-rich settings with little to no light penetration. These broad categories of carbonate sediment producers have also been recognised to dominate in specific carbonate systems. Photozoans are commonly dominant in flat-topped platforms with steep margins, while Heterozoans generally dominate carbonate ramps. However, comparatively little is known on how these two main groups of carbonate producers interact in the same system and impact depositional geometries responding to changes in environmental conditions such as sea level fluctuation, antecedent slope, sediment transport processes, etc. This thesis presents numerical models to investigate the evolution of Miocene carbonate systems in the Mediterranean from two shallow marine domains: 1) a Miocene flat-topped platform dominated by Photozoans, with a significant component of Hetrozoans in the slope and 2) a Heterozoan distally steepened ramp, with seagrass-influenced (Photozoan) inner ramp. The overarching aim of the three articles comprising this cumulative thesis is to provide a numerical study of the role of Photozoans and Heterozoans in the evolution of carbonate system geometries and how these biotas respond to changes in environmental conditions. This aim was achieved using stratigraphic forward modelling, which provides an approach to quantitatively integrate multi-scale datasets to reconstruct sedimentary processes and products during the evolution of a sedimentary system.
In a Photozoan-dominated carbonate system, such as the Miocene Llucmajor platform in Western Mediterranean, stratigraphic forward modelling dovetailed with a robust set of sensitivity tests reveal how the geometry of the carbonate system is determined by the complex interaction of Heterozoan and Photozoan biotas in response to variable conditions of sea level fluctuation, substrate configuration, sediment transport processes and the dominance of Photozoan over Heterozoan production. This study provides an enhanced understanding of the different carbonate systems that are possible under different ecological and hydrodynamic conditions. The research also gives insight into the roles of different biotic associations in the evolution of carbonate geometries through time and space. The results further show that the main driver of platform progradation in a Llucmajor-type system is the lowstand production of Heterozoan sediments, which form the necessary substratum for Photozoan production.
In Heterozoan systems, sediment production is mainly characterised by high transport deposits, that are prone to redistribution by waves and gravity, thereby precluding the development of steep margins. However, in the Menorca ramp, the occurrence of sediment trapping by seagrass led to the evolution of distal slope steepening. We investigated, through numerical modelling, how such a seagrass-influenced ramp responds to the frequency and amplitude of sea level changes, variable carbonate production between the euphotic and oligophotic zone, and changes in the configuration of the paleoslope. The study reinforces some previous hypotheses and presents alternative scenarios to the established concepts of high-transport ramp evolution. The results of sensitivity experiments show that steep slopes are favoured in ramps that develop in high-frequency sea level fluctuation with amplitudes between 20 m and 40 m. We also show that ramp profiles are significantly impacted by the paleoslope inclination, such that an optimal antecedent slope of about 0.15 degrees is required for the Menorca distally steepened ramp to develop.
The third part presents an experimental case to argue for the existence of a Photozoan sediment threshold required for the development of steep margins in carbonate platforms. This was carried out by developing sensitivity tests on the forward models of the flat-topped (Llucmajor) platform and the distally steepened (Menorca) platform. The results show that models with Photozoan sediment proportion below a threshold of about 40% are incapable of forming steep slopes. The study also demonstrates that though it is possible to develop steep margins by seagrass sediment trapping, such slopes can only be stabilized by the appropriate sediment fabric and/or microbial binding. In the Photozoan-dominated system, the magnitude of slope steepness depends on the proportion of Photozoan sediments in the system. Therefore, this study presents a novel tool for characterizing carbonate systems based on their biogenic components.
The central gas in half of all galaxy clusters shows short cooling times. Assuming unimpeded cooling, this should lead to high star formation and mass cooling rates, which are not observed. Instead, it is believed that condensing gas is accreted by the central black hole that powers an active galactic nuclei jet, which heats the cluster. The detailed heating mechanism remains uncertain. A promising mechanism invokes cosmic ray protons that scatter on self-generated magnetic fluctuations, i.e. Alfvén waves. Continuous damping of Alfvén waves provides heat to the intracluster medium. Previous work has found steady state solutions for a large sample of clusters where cooling is balanced by Alfvénic wave heating. To verify modeling assumptions, we set out to study cosmic ray injection in three-dimensional magnetohydrodynamical simulations of jet feedback in an idealized cluster with the moving-mesh code arepo. We analyze the interaction of jet-inflated bubbles with the turbulent magnetized intracluster medium.
Furthermore, jet dynamics and heating are closely linked to the largely unconstrained jet composition. Interactions of electrons with photons of the cosmic microwave background result in observational signatures that depend on the bubble content. Those recent observations provided evidence for underdense bubbles with a relativistic filling while adopting simplifying modeling assumptions for the bubbles. By reproducing the observations with our simulations, we confirm the validity of their modeling assumptions and as such, confirm the important finding of low-(momentum) density jets.
In addition, the velocity and magnetic field structure of the intracluster medium have profound consequences for bubble evolution and heating processes. As velocity and magnetic fields are physically coupled, we demonstrate that numerical simulations can help link and thereby constrain their respective observables. Finally, we implement the currently preferred accretion model, cold accretion, into the moving-mesh code arepo and study feedback by light jets in a radiatively cooling magnetized cluster. While self-regulation is attained independently of accretion model, jet density and feedback efficiencies, we find that in order to reproduce observed cold gas morphology light jets are preferred.
Mitochondria and plastids are organelles with an endosymbiotic origin. During evolution, many genes are lost from the organellar genomes and get integrated in the nuclear genome, in what is known as intracellular/endosymbiotic gene transfer (IGT/EGT). IGT has been reproduced experimentally in Nicotiana tabacum at a gene transfer rate (GTR) of 1 event in 5 million cells, but, despite its centrality to eukaryotic evolution, there are no genetic factors known to influence the frequency of IGT in higher eukaryotes. The focus of this work was to determine the role of different DNA repair pathways of double strand break repair (DSBR) in the integration step of organellar DNA in the nuclear genome during IGT. Here, a CRISPR/Cas9 mutagenesis strategy was implemented in N. tabacum, with the aim of generating mutants in nuclear genes without expected visible phenotypes. This strategy led to the generation of a collection of independent mutants in the LIG4 (necessary for non-homologous end joining, NHEJ) and POLQ genes (necessary for microhomology mediated end joining, MMEJ). Targeting of other DSBR genes (KU70, KU80, RPA1C) generated mutants with unexpectedly strong developmental phenotypes.. These factors have telomeric roles, hinting towards a possible relationship between telomere length, and strength of developmental disruption upon loss of telomere structure in plants. The mutants were made in a genetic background encoding a plastid-encoded IGT reporter, that confers kanamycin resistance upon transfer to the nucleus. Through large scale independent experiments, increased IGT from the chloroplast to the nucleus was observed in lig4 mutants, as well as lines encoding a POLQ gene with a defective polymerase domain (polqΔPol). This shows that NHEJ or MMEJ have a double-sided relationship with IGT: while transferred genes may integrate using either pathway, the presence of both pathways suppresses IGT in wild-type somatic cells, thus demonstrating for the first time the extent on which nuclear genes control IGT frequency in plants. The IGT frequency increases in the mutants are likely mediated by increased availability of double strand breaks for integration. Additionally, kinetic analysis reveals that gene transfer (GT) events accumulate linearly as a function of time spent under antibiotic selection in the experiment, demonstrating that, contrary to what was previously thought, there is no such thing as a single GTR in somatic IGT experiments. Furthermore, IGT in tissue culture experiments appears to be the result of a "race against the clock" for integration in the nuclear genome, that starts when the organellar DNA arrives to the nucleus granting transient antibiotic resistance. GT events and escapes of kanamycin selection may be two possible outcomes from this race: those instances where the organellar DNA gets to integrate are recovered as GT events, and in those cases where timely integration fails, antibiotic resistance cannot be sustained, and end up considered as escapes. In the mutants, increased opportunities for integration in the nuclear genome change the overall ratio between IGT and escape events. The resources generated here are promising starting points for future research: (1) the mutant collection, for the further study of processes that depend on DNA repair in plants (2) the collection of GT lines obtained from these experiments, for the study of the effect of DSBR pathways over integration patterns and stability of transferred genes and (3) the developed CRISPR/Cas9 workflow for mutant generation, to make N. tabacum meet its potential as an attractive model for answering complex biological questions.
The G protein-coupled estrogen receptor (GPER1) is acknowledged as an important mediator of estrogen signaling. Given the ubiquitous expression of GPER1, it is likely that the receptor plays a role in a variety of malignancies, not only in the classic hormonally regulated tissues (e.g., breast, ovary, and prostate), but also in the colon. As colorectal cancer (CRC) is the third most common cancer in both men and women worldwide and environmental factors and dietary habits are important risk factors, it is increasingly recognized that natural and synthetic hormones and their associated receptors might play a role in CRC. Through oral consumption, environmental contaminants with endocrine activity are in contact with the gastrointestinal mucosa, where they might exert their toxic effects. Although GPER1 has been shown to be engaged in physiological and pathophysiological processes, its role in CRC remains poorly understood. Thus, pro- as well as anti-tumorigenic effects are described in the literature. This thesis has uncovered novel roles of GPER1 in mediating major CRC-associated phenotypes in transformed and non-transformed colon cell lines. Exposure to the estrogens 17β-estradiol (E2), bisphenol-A (BPA) and diethylstilbestrol (DES) but also the androgen dihydrotestosterone (DHT) resulted in GPER1-dependent induction of supernumerary centrosomes, whole chromosomal instability (w-CIN) and aneuploidy. Indeed, both knockdown and inhibition of GPER1 attenuated the generation of (xeno)hormone-driven supernumerary centrosomes and karyotype instability. Mechanistically, (xeno)hormone-induced centrosome amplification was associated with transient multipolar mitosis and the generation of so called anaphase “lagging” chromosomes. The results of this thesis propose a GPER1/PKA/AKAP9-pathway in regulating centrosome numbers in colorectal cancer cells and the involvement of the centriolar protein centrin. Remarkably, exposure to (xeno)hormones resulted in atypical enlargement and unexpected phosphorylation of the centriole marker centrin in interphase. These findings provide a novel role for GPER1 in key CRC-prone lesions and shed light on underlying mechanisms that involve GPER1 function in the colon. Elucidating to what extent centrosomal proteins are involved in the GPER1-mediated aneugenic effect will be an important task for future studies. The present study was intended to lay a first foundation to understand the molecular basis and potential risk factors of CRC which might help to reduce the use of laboratory animals. Since numerous animal experiments are conducted in biomedical research, the development of alternative methods is indispensable. The Federal Institute for Risk Assessment (BfR) as the German Center for the Protection of Laboratory Animals (Bf3R) addresses this issue by uncovering underlying mechanisms leading to colorectal cancer as necessary prerequisite in order to develop alternative methods.
This book offers a comprehensive, multidisciplinary introduction to theme parks and the field of theme park studies. It identifies and discusses relevant economic, social, and cultural as well as medial, historical, and geographical aspects of theme parks worldwide, from the big international theme park chains to smaller, regional, family-operated parks. The book also describes the theories and methods that have been used to study theme parks in various academic disciplines and reviews the major contexts in which theme parks have been studied. By providing the necessary backgrounds, theories, and methods to analyze and understand theme parks both as a business field and as a socio-cultural phenomenon, this book will be a great resource to students, academics from all disciplines interested in theme parks, and professionals and policy-makers in the leisure and entertainment as well as the urban planning sector.
The Tetrarchy as Ideology
(2023)
The 'Tetrarchy', the modern name assigned to the period of Roman history that started with the emperor Diocletian and ended with Constantine I, has been a much-studied and much-debated field of the Roman Empire. Debate, however, has focused primarily on whether it was a true 'system' of government, or rather a collection of ad-hoc measures undertaken to stabilise the empire after the troubled period of the 3rd century CE. The papers collected here aim to go beyond this question and to present an innovative approach to a fascinating period of Roman history by understanding the Tetrarchy not as a system of government, but primarily as a political language. Their focus thus lies on the language and ideology of the imperial college and court, on the performance of power in imperial ceremonies, the representation of the emperors and their enemies in the provinces of the Roman world, as well as on the afterlife of Tetrarchic power in the Constantinian period.
Die Fallsammlung ermöglicht zum einen eine exemplarische Wiederholung und Vertiefung des wirtschaftsstrafrechtlichen Basiswissens und zum anderen die Anwendung dieses Wissens auf ausbildungs- und praxisrelevante Sachverhalte. Einige Fälle weisen Bezüge zum Steuer- und Umweltstrafrecht auf, da diese Rechtsgebiete in manchen Ausbildungsordnungen mit dem Wirtschaftsstrafrecht verknüpft sind.Berücksichtigt wurden die zahlreichen Änderungen wirtschaftsstrafrechtlicher Gesetze sowie eine Fülle neuer gerichtlicher Entscheidungen und Stellungnahmen in der Literatur.
Verantwortungseigentum ist mittlerweile mehr als ein Nischenthema innerhalb der Rechtswissenschaft und unternehmerischen Praxis. Unternehmen werden in Verantwortungseigentum gegründet oder umgewandelt, also die persönlichen Gewinne der Gesellschafter perpetuiert und die Nachfolge reguliert. Auch der Profifußball stellt sich immer wieder die Frage nach der richtigen Balance zwischen Gewinnstreben und Gemeinwohl. Das wirft Fragen nach alternativen Gestaltungsmöglichkeiten auf, für die das Verantwortungseigentum eine Lösung bieten könnte.
Beinahe 30 Jahre lang glänzte die »Völkerfreundschaft« zwischen Kuba und der DDR im öffentlichen Diskurs der SED als Musterbeispiel ihres proletarischen Internationalismus. Doch die Rhetorik täuscht: Besonders in den Anfangsjahren der bilateralen Beziehungen nahmen die deutschen Kader ihre kubanischen »Genossen« in der Karibik als notorische Querschläger wahr, die mit ihrem Aufbegehren gegen den ideologischen Suprematieanspruch des Kremls die Stabilität des Ostblocks gefährdeten.
Anhand bislang unveröffentlichten Quellenmaterials aus deutschen und kubanischen Archiven veranschaulicht Antonia Bihlmayer die Bemühungen der Regierung Walter Ulbrichts, die widerspenstigen Sozialisten in der Karibik auf Moskau auszurichten. Auf politisch-ideologischer, wirtschaftlicher und kulturpolitischer Ebene analysiert ihre Studie zum einen die Charakteristika dieser sozialistischen Zivilisierungsmission. Zum anderen nimmt sie diejenigen Faktoren in den Blick, die dafür ausschlaggebend waren, dass sich diese beiden sozialistischen Enklaven ab Mitte der 1970er Jahre schließlich zu gleichwertigen »Juniorpartnern« der Sowjetunion entwickelten.
Photosynthesis converts light into metabolic energy which fuels plant growth. In nature, many factors influence light availability for photosynthesis on different time scales, from shading by leaves within seconds up to seasonal changes over months. Variability of light energy supply for photosynthesis can limit a plant´s biomass accumulation. Plants have evolved multiple strategies to cope with strongly fluctuation light (FL). These range from long-term optimization of leaf morphology and physiology and levels of pigments and proteins in a process called light acclimation, to rapid changes in protein activity within seconds. Therefore, uncovering how plants deal with FL on different time scales may provide key ideas for improving crop yield. Photosynthesis is not an isolated process but tightly integrates with metabolism through mutual regulatory interactions. We thus require mechanistic understanding of how long-term light acclimation shapes both, dynamic photosynthesis and its interactions with downstream metabolism. To approach this, we analyzed the influence of growth light on i) the function of known rapid photosynthesis regulators KEA3 and VCCN1 in dynamic photosynthesis (Chapter 2-3) and ii) the interconnection of photosynthesis with photorespiration (PR; Chapter 4).
We approached topic (i) by quantifying the effect of different growth light regimes on photosynthesis and photoprotection by using kea3 and vccn1 mutants. Firstly, we found that, besides photosynthetic capacity, the activities of VCCN1 and KEA3 during a sudden high light phase also correlated with growth light intensity. This finding suggests regulation of both proteins by the capacity of downstream metabolism. Secondly, we showed that KEA3 accelerated photoprotective non-photochemical quenching (NPQ) kinetics in two ways: Directly via downregulating the lumen proton concentration and thereby de-activating pH-dependent NPQ, and indirectly via suppressing accumulation of the photoprotective pigment zeaxanthin.
For topic (ii), we analyzed the role of PR, a process which recycles a toxic byproduct of the carbon fixation reactions, in metabolic flexibility in a dynamically changing light environment. For this we employed the mutants hpr1 and ggt1 with a partial block in PR. We characterized the function of PR during light acclimation by tracking molecular and physiological changes of the two mutants. Our data, in contrast to previous reports, disprove a generally stronger physiological relevance of PR under dynamic light conditions. Additionally, the two different mutants showed pronounced and distinct metabolic changes during acclimation to a condition inducing higher photosynthetic activity. This underlines that PR cannot be regarded purely as a cyclic detoxification pathway for 2PG. Instead, PR is highly interconnected with plant metabolism, with GGT1 and HPR1 representing distinct metabolic modulators.
In summary, the presented work provides further insight into how energetic and metabolic flexibility is ensured by short-term regulators and PR during long-term light acclimation.
Parlamentarismus bezeichnet die Idee der Repräsentation Regierter durch gewählte Abgeordnete. Er entfaltete sich hierzulande seit dem frühen 19. Jahrhundert im Zusammenwirken mit Vereinen und Verbänden, Parteien und Bewegungen, innerhalb komplementärer oder auch konkurrierender Strukturen und Prinzipien. Das Selbst- und Fremdbild, die Zusammensetzung, Themen und Debattenkultur deutscher Parlamente als politische Akteure bildet damit bis heute zugleich eine Art Resonanzboden gesellschaftlicher und politischer Verhältnisse.
Welcher Weg führte von den zunächst kaum wirkmächtigen und nicht im Ansatz repräsentativen Parlamenten der Restaurationszeit über die Paulskirche bis in die Gegenwart? Wie gestalteten sich die Beziehungen zwischen dem Parlamentarismus und dem Föderalismus? Wie entwickelten sich Wahlen und Wahlsysteme als Grundlage allgemeiner Repräsentation? Wer sah oder sieht sich im Parlamentarismus in-, wer exkludiert? Wie leben und arbeiten Parlamentsangehörige ehedem und heute? Welche Formen medialer Interaktion zwischen ihnen und der Öffentlichkeit haben sich herausgebildet? Worin gründen Vorbehalte, Reformwünsche, aber auch Anfeindungen des Parlamentarismus? Und welchen Herausforderungen wird sich die repräsentative Demokratie in Zukunft stellen müssen?
Funken
(2023)
Bereits im vorschulischen Bereich, aber vor allem in der Grundschule entwickeln Kinder wichtige Kompetenzen für spätere Bildungsabschlüsse. Doch die Kompe-tenzunterschiede zwischen den Schüler:innen sind bereits zu Beginn der Grund-schulzeit beträchtlich. Somit kommt den Lehrkräften die überaus wichtige Aufga-be zu allen Kindern den für sie besten Bildungsweg zu ermöglichen. Um dieser Herausforderung zu begegnen, müssen Diagnostik und Förderung im Unterricht Hand in Hand gehen. Deshalb wird die Diagnosekompetenz von Lehrkräften als wichtige Voraussetzung für gelingenden Unterricht angesehen. Diese Dissertation widmet sich nun eben dieser wichtigen Kompetenz. Dabei wird sie als mehrdimen-sionales Konstrukt angesehen, zu dem neben der Beurteilung von fachlichen Kompetenzen auch die Einschätzung des Leistungsstandes und die Schlussfolge-rung hinsichtlich notwendiger Förderung im Unterricht gehören. Anhand dreier Artikel sowie ergänzender theoretischer Betrachtungen wurde die Diagnosekompe-tenz hinsichtlich möglicher Einflussfaktoren, der Bedeutung für den Unterricht sowie für die Lehrer:innenbildung untersucht.
De/lirios
(2023)
En base al concepto de "de/lirio", que articula trastornos en la enunciación literaria en primera persona, por un lado, con la caracterización psicopatológica de este yo enunciativo, por otro lado, el estudio explora las "líricas desviadas" de Mario Levrero y Alberto Laiseca, y muestra como responden productivamente a problemáticas estéticas, éticas y ontológicas propias de la vuelta del milenio, en el Río de la Plata y más allá.
Background: The characteristics of osteoporosis are decreased bone mass and destruction towards the microarchitecture of bone tissue, which raises the risk of fracture. Psychosocialstress and osteoporosis are linked by sympathetic nervous system, hypothalamic-pituitary-adrenal axis, and other endocrine factors. Psychosocial stress causes a series of effects on the organism, and this long-term depletion at the cellular level is considered to be mitochondrial allostatic load, including mitochondrial dysfunction and oxidative stress. Extracellular vesicles (EVs) are involved in the mitochondrial allostatic load process and may as biomarkers in this setting. As critical participants during cell-to-cell communications, EVs serve as transport vehicles for nucleic acid and proteins, alter the phenotypic and functional characteristics of their target cells, and promote cell-to-cell contact. And hence, they play a significant role in the diagnosis and therapy of many diseases, such as osteoporosis.
Aim: This narrative review attempts to outline the features of EVs, investigate their involvement in both psychosocial stress and osteoporosis, and analyze if EVs can be potential mediators between both.
Methods: The online database from PubMed, Google Scholar, and Science Direct were searched for keywords related to the main topic of this study, and the availability of all the selected studies was verified. Afterward, the findings from the articles were summarized and synthesized.
Results: Psychosocial stress affects bone remodeling through increased neurotransmitters such as glucocorticoids and catecholamines, as well as increased glucose metabolism. Furthermore, psychosocial stress leads to mitochondrial allostatic load, including oxidative stress, which may affect bone remodeling. In vitro and in vivo data suggest EVs might involve in the link between psychosocial stress and bone remodeling through the transfer of bioactive substances and thus be a potential mediator of psychosocial stress leading to osteoporosis.
Conclusions: According to the included studies, psychosocial stress affects bone remodeling, leading to osteoporosis. By summarizing the specific properties of EVs and the function of EVs in both psychosocial stress and osteoporosis, respectively, it has been demonstrated that EVs are possible mediators of both, and have the prospects to be useful in innovative research areas.
The light reactions of photosynthesis are carried out by a series of multiprotein complexes embedded in thylakoid membranes. Among them, photosystem I (PSI), acting as plastocyanin-ferderoxin oxidoreductase, catalyzes the final reaction. Together with light-harvesting antenna I, PSI forms a high-molecular-weight supercomplex of ~600 kDa, consisting of eighteen subunits and nearly two hundred co-factors. Assembly of the various components into a functional thylakoid membrane complex requires precise coordination, which is provided by the assembly machinery. Although this includes a small number of proteins (PSI assembly factors) that have been shown to play a role in the formation of PSI, the process as a whole, as well as the intricacy of its members, remains largely unexplored.
In the present work, two approaches were used to find candidate PSI assembly factors. First, EnsembleNet was used to select proteins thought to be functionally related to known PSI assembly factors in Arabidopsis thaliana (approach I), and second, co-immunoprecipitation (Co-IP) of tagged PSI assembly factors in Nicotiana tabacum was performed (approach II).
Here, the novel PSI assembly factors designated CO-EXPRESSED WITH PSI ASSEMBLY 1 (CEPA1) and Ycf4-INTERACTING PROTEIN 1 (Y4IP1) were identified. A. thaliana null mutants for CEPA1 and Y4IP1 showed a growth phenotype and pale leaves compared with the wild type. Biophysical experiments using pulse amplitude modulation (PAM) revealed insufficient electron transport on the PSII acceptor side. Biochemical analyses revealed that both CEPA1 and Y4IP1 are specifically involved in PSI accumulation in A. thaliana at the post-translational level but are not essential. Consistent with their roles as factors in the assembly of a thylakoid membrane protein complex, the two proteins localize to thylakoid membranes. Remarkably, cepa1 y4ip1 double mutants exhibited lethal phenotypes in early developmental stages under photoautotrophic growth. Finally, co-IP and native gel experiments supported a possible role for CEPA1 and Y4IP1 in mediating PSI assembly in conjunction with other PSI assembly factors (e.g., PPD1- and PSA3-CEPA1 and Ycf4-Y4IP1). The fact that CEPA1 and Y4IP1 are found exclusively in green algae and higher plants suggests eukaryote-specific functions. Although the specific mechanisms need further investigation, CEPA1 and Y4IP1 are two novel assembly factors that contribute to PSI formation.
Social Scoring
(2023)
Das Fenster zum Garten
(2023)
Whistleblowing
(2023)
Taubblind, Juristin
(2023)
The Right to Research
(2023)
Refugees and displaced people rarely figure as historical actors, and almost never as historical narrators. We often assume a person residing in a refugee camp, lacking funding, training, social networks, and other material resources that enable the research and writing of academic history, cannot be a historian because a historian cannot be a person residing in a refugee camp.
The Right to Research disrupts this tautology by featuring nine works by refugee and host-community researchers from across Africa, Europe, and the Middle East. Identifying the intrinsic challenges of making space for diverse voices within a research framework and infrastructure that is inherently unequal, this edited volume offers a critical reflection on what history means, who narrates it, and what happens when those long excluded from authorship bring their knowledge and perspectives to bear. Chapters address topics such as education in Kakuma Refugee Camp, the political power of hip-hop in Rwanda, women migrants to Yemen, and the development of photojournalism in Kurdistan.
Exploring what it means to become a researcher, The Right to Research understands historical scholarship as an ongoing conversation - one in which we all have a right to participate.
Im Rahmen dieser Dissertation wurden die erstmaligen Totalsynthesen der Arylnaphthalen-Lignane Alashinol D, Vitexdoin C, Vitrofolal E, Noralashinol C1 und Ternifoliuslignan E vorgestellt. Der Schlüsselschritt der entwickelten Methode, basiert auf einer regioselektiven intramolekularen Photo-Dehydro-Diels-Alder (PDDA)-Reaktion, die mittels UV-Strahlung im Durchflussreaktor durchgeführt wurde. Bei der Synthese der PDDA-Vorläufer (Diarylsuberate) wurde eine Synthesestrategie nach dem Baukastenprinzip verfolgt. Diese ermöglicht die Darstellung asymmetrischer komplexer Systeme aus nur wenigen Grundbausteinen und die Totalsynthese einer Vielzahl an Lignanen. In systematischen Voruntersuchungen konnte zudem die klare Überlegenheit der intra- gegenüber der intermolekularen PDDA-Reaktion aufgezeigt werden. Dabei stellte sich eine Verknüpfung der beiden Arylpropiolester über einen Korksäurebügel, in para-Position, als besonders effizient heraus. Werden asymmetrisch substituierte Diarylsuberate, bei denen einer der endständigen Estersubstituenten durch eine Trimethylsilyl-Gruppe oder ein Wasserstoffatom ersetzt wurde, verwendet, durchlaufen diese Systeme eine regioselektive Cyclisierung und als Hauptprodukt werden Naphthalenophane mit einem Methylester in 3-Position erhalten. Mit Hilfe von umfangreichen Experimenten zur Funktionalisierung der 4-Position, konnte zudem gezeigt werden, dass die Substitution der nucleophilen Cycloallen-Intermediate, während der PDDA-Reaktion, generell durch die Zugabe von N-Halogen-Succinimiden möglich ist. In Anbetracht der geringen Ausbeuten haben diese intermolekularen Abfangreaktionen, jedoch keinen präparativen Nutzen für die Totalsynthesen von Lignanen. Mit dem Ziel die allgemeinen photochemischen Reaktionsbedingungen zu optimieren, wurde erstmalig die triplettsensibilisierte PDDA-Reaktion vorgestellt. Durch die Verwendung von Xanthon als Sensibilisator wurde der Einsatz von effizienteren UVA-Lichtquellen ermöglicht, wodurch die Gefahr einer Photozersetzung durch Überbestrahlung minimiert wurde. Im Vergleich zur direkten Anregung mit UVB-Strahlung, konnten die Ausbeuten mit indirekter Anregung durch einen Photokatalysator signifikant gesteigert werden. Die grundlegenden Erkenntnisse und die entwickelten Synthesestrategien dieser Arbeit, können dazu beitragen zukünftig die Erschließung neuer pharmakologisch interessanter Lignane voranzutreiben.
1 Bisher ist nur die semisynthetische Darstellung von Noralashinol C ausgehend von Hydroxymatairesinol literaturbekannt.
Der französische Autor Michel Houellebecq und sein literarisches Werk sorgen in der medialen Öffentlichkeit regelmäßig für Skandale, die Vorwürfe reichen von bewusster Provokation bis hin zu diversen Diskriminierungen. Dabei unterstützt Houellebecq durch seine mediale Selbstinszenierung die Verwischung zwischen sich selbst als realer Person und den Erzählstimmen seiner Texte. Dies führt auch in der Literaturwissenschaft zu wiederholten Versuchen, dem Schriftsteller und seinen Romanen eine politische Position zuzuschreiben.
Im Gegensatz dazu ist das Ziel dieser Abschlussarbeit, am Beispiel des 2015 bei Flammarion publizierten Romans Soumission – welchem neben Misogynie auch Islam- und Homofeindlichkeit vorgeworfen wurde –, herauszustellen, wie der Text Widerstände gegen konkrete politische Positionierungen und starre Bedeutungszuschreibungen aufweist. Über eine Analyse der Männlichkeits- und Weiblichkeitsentwürfe im Sinne dekonstruktiver Gendertheorien sowie über eine intertextuelle und postkoloniale Perspektivierung werden die Ambivalenz und das provokative Potential des Textes herausgearbeitet. Das intertextuelle Verweisspiel des Romans und die Systemreferenz zur Décadence, besonders durch Bezüge zu Einzeltexten und zur Biografie des Autors Joris-Karl Huysmans, bilden eine wichtige Grundlage sowohl für das zentrale Thema der religiösen Konversion, die textimmanente Bedeutung der Literatur, als auch für die Geschlechterkonstruktionen. Trotz der Stereotypisierung von Frauenfiguren, deren gesellschaftlicher Wert vom sexuellen Begehren eines Mannes abhängt, oder der orientalistischen Darstellung des Islams entwirft Soumission eine komplexe Inszenierung von Männlichkeitsvorstellungen. Dies zeigt sich in der verunsicherten männlichen Identität des Protagonisten François, die zwischen universalem Anspruch und individueller Einzigartigkeit changiert und gleichzeitig, wie auch jene von anderen männlichen Figuren, eine strikte, stereotype Geschlechterbinarität unterläuft. Die Verunsicherung der Identität des Protagonisten spiegelt die der französischen Gesellschaft wider, dabei verfügen nur der fiktive Islam und dessen Genderpolitik über ausreichend Stärke, dem kulturellen Verfall des Westens etwas entgegenzusetzen. Der religiösen Konversion zum Islam wird eine korrektive und erlösende Funktion zugeschrieben, die in dem Akt der Unterwerfung ihren Höhepunkt findet.
In den Translationsprozessen von französischer, christlich geprägter in eine muslimisch fundierte Kultur offenbart sich nicht nur ein Angriff auf die akademische Bildungselite Frankreichs, sondern auch auf das Wissen der Literatur. Indem eine Re- und Uminterpretation literarischer Texte durch den Protagonisten und weitere Figuren für die neue fundamentalistische Gesellschaftsordnung vorgenommen wird, offenbart sich neben binären Geschlechterkonstruktionen und diversen politischen Positionierungen auch das nationale Narrativ der französischen Literatur als labile Fiktion.
In recent decades, astronomy has seen a boom in large-scale stellar surveys of the Galaxy. The detailed information obtained about millions of individual stars in the Milky Way is bringing us a step closer to answering one of the most outstanding questions in astrophysics: how do galaxies form and evolve? The Milky Way is the only galaxy where we can dissect many stars into their high-dimensional chemical composition and complete phase space, which analogously as fossil records can unveil the past history of the genesis of the Galaxy. The processes that lead to large structure formation, such as the Milky Way, are critical for constraining cosmological models; we call this line of study Galactic archaeology or near-field cosmology.
At the core of this work, we present a collection of efforts to chemically and dynamically characterise the disks and bulge of our Galaxy. The results we present in this thesis have only been possible thanks to the advent of the Gaia astrometric satellite, which has revolutionised the field of Galactic archaeology by precisely measuring the positions, parallax distances and motions of more than a billion stars. Another, though not less important, breakthrough is the APOGEE survey, which has observed spectra in the near-infrared peering into the dusty regions of the Galaxy, allowing us to determine detailed chemical abundance patterns in hundreds of thousands of stars. To accurately depict the Milky Way structure, we use and develop the Bayesian isochrone fitting tool/code called StarHorse; this software can predict stellar distances, extinctions and ages by combining astrometry, photometry and spectroscopy based on stellar evolutionary models. The StarHorse code is pivotal to calculating distances where Gaia parallaxes alone cannot allow accurate estimates.
We show that by combining Gaia, APOGEE, photometric surveys and using StarHorse, we can produce a chemical cartography of the Milky way disks from their outermost to innermost parts. Such a map is unprecedented in the inner Galaxy. It reveals a continuity of the bimodal chemical pattern previously detected in the solar neighbourhood, indicating two populations with distinct formation histories. Furthermore, the data reveals a chemical gradient within the thin disk where the content of 𝛼-process elements and metals is higher towards the centre. Focusing on a sample in the inner MW we confirm the extension of the chemical duality to the innermost regions of the Galaxy. We find stars with bar shape orbits to show both high- and low-𝛼 abundances, suggesting the bar formed by secular evolution trapping stars that already existed. By analysing the chemical orbital space of the inner Galactic regions, we disentangle the multiple populations that inhabit this complex region. We reveal the presence of the thin disk, thick disk, bar, and a counter-rotating population, which resembles the outcome of a perturbed proto-Galactic disk. Our study also finds that the inner Galaxy holds a high quantity of super metal-rich stars up to three times solar suggesting it is a possible repository of old super-metal-rich stars found in the solar neighbourhood.
We also enter into the complicated task of deriving individual stellar ages. With StarHorse, we calculate the ages of main-sequence turn-off and sub-giant stars for several public spectroscopic surveys. We validate our results by investigating linear relations between chemical abundances and time since the 𝛼 and neutron capture elements are sensitive to age as a reflection of the different enrichment timescales of these elements. For further study of the disks in the solar neighbourhood, we use an unsupervised machine learning algorithm to delineate a multidimensional separation of chrono-chemical stellar groups revealing the chemical thick disk, the thin disk, and young 𝛼-rich stars. The thick disk is shown to have a small age dispersion indicating its fast formation contrary to the thin disk that spans a wide range of ages.
With groundbreaking data, this thesis encloses a detailed chemo-dynamical view of the disk and bulge of our Galaxy. Our findings on the Milky Way can be linked to the evolution of high redshift disk galaxies, helping to solve the conundrum of galaxy formation.
Sin domicilio fijo
(2023)
Angesichts der dramatischen Lage in der Ukraine untersucht der folgende Beitrag, auf welchem Wege, vor welchen völkerrechtlichen Gerichten, in welchem Umfang und mit welcher Aussicht auf Erfolg die Ukraine oder einzelne ukrainische Staatsangehörige Sicherheitsschutz vor der russischen Invasion und/oder den im Zusammenhang damit bereits begangenen oder noch bevorstehenden Völkerrechtsverstößen Rechtsschutz erlangen können. Im Einzelnen handelt es sich hierbei um zwei anhängige Verfahren vor dem Internationalen Gerichtshof, mehrere Staaten- sowie eine große Vielzahl von Individualbeschwerden vor dem Europäischen Gerichtshof für Menschenrechte; ein Verfahren vor dem Internationalen Seegerichtshof; zahlreiche Investitionsverfahren vor internationalen Schiedsgerichten sowie schließlich zwei "Situationen" vor dem Internationalen Strafgerichtshof. Abschließend wird die Option der Schaffung eines ad-hoc-Tribunals für das Verbrechen der Aggression behandelt.
Wirtschafts- und Sozialverträglichkeit des Klimaschutzes als Verfassungsgebot und Staatsräson
(2023)
A right to research?
(2023)
Das menschenrechtliche Prinzip des Non-Refoulement vor den Vertragsorganen der Vereinten Nationen
(2023)
Die Vertragsorgane der Vereinten Nationen können durch die Abstimmung ihrer Praxis Rechtssicherheit schaffen, und zwar sowohl für Betroffene als auch für die Vertragsstaaten. Durch den ständigen Dialog mit den Vertragsstaaten, die Beeinflussung der Vertragsorgane untereinander und das Aufgreifen der Praxis durch andere internationale Akteure lässt sich Gewohnheitsrecht identifizieren. -- Dabei ist das menschenrechtliche Prinzip des Non-Refoulement besonders geeignet, dieses Potenzial der Vertragsorgane zu veranschaulichen. Hierbei handelt es sich um ein Rechtsprinzip, das zwar dem Grunde nach allgemein anerkannt ist, dessen Reichweite im Detail jedoch kontinuierlich umstritten ist. Erstmals wird ein umfassender Überblick über die gesamte Praxis der Vertragsorgane zum Prinzip des Non-Refoulement gegeben. Es wird gezeigt, wie sich die Vertragsorgane sowohl auf prozessualer Ebene als auch bei der Bestimmung des materiellen Schutzbereichs von Refoulementverboten einander annähern.
Cosmic rays (CRs) constitute an important component of the interstellar medium (ISM) of galaxies and are thought to play an essential role in governing their evolution. In particular, they are able to impact the dynamics of a galaxy by driving galactic outflows or heating the ISM and thereby affecting the efficiency of star-formation. Hence, in order to understand galaxy formation and evolution, we need to accurately model this non-thermal constituent of the ISM. But except in our local environment within the Milky Way, we do not have the ability to measure CRs directly in other galaxies. However, there are many ways to indirectly observe CRs via the radiation they emit due to their interaction with magnetic and interstellar radiation fields as well as with the ISM.
In this work, I develop a numerical framework to calculate the spectral distribution of CRs in simulations of isolated galaxies where a steady-state between injection and cooling is assumed. Furthermore, I calculate the non-thermal emission processes arising from the modelled CR proton and electron spectra ranging from radio wavelengths up to the very high-energy gamma-ray regime.
I apply this code to a number of high-resolution magneto-hydrodynamical (MHD) simulations of isolated galaxies, where CRs are included. This allows me to study their CR spectra and compare them to observations of the CR proton and electron spectra by the Voyager-1 satellite and the AMS-02 instrument in order to reveal the origin of the measured spectral features.
Furthermore, I provide detailed emission maps, luminosities and spectra of the non-thermal emission from our simulated galaxies that range from dwarfs to Milk-Way analogues to starburst galaxies at different evolutionary stages. I successfully reproduce the observed relations between the radio and gamma-ray luminosities with the far-infrared (FIR) emission of star-forming (SF) galaxies, respectively, where the latter is a good tracer of the star-formation rate. I find that highly SF galaxies are close to the limit where their CR population would lose all of their energy due to the emission of radiation, whereas CRs tend to escape low SF galaxies more quickly. On top of that, I investigate the properties of CR transport that are needed in order to match the observed gamma-ray spectra.
Furthermore, I uncover the underlying processes that enable the FIR-radio correlation (FRC) to be maintained even in starburst galaxies and find that thermal free-free-emission naturally explains the observed radio spectra in SF galaxies like M82 and NGC 253 thus solving the riddle of flat radio spectra that have been proposed to contradict the observed tight FRC.
Lastly, I scrutinise the steady-state modelling of the CR proton component by investigating for the first time the influence of spectrally resolved CR transport in MHD simulations on the hadronic gamma-ray emission of SF galaxies revealing new insights into the observational signatures of CR transport both spectrally and spatially.
Neue Wege ins Lehramt
(2023)
Bis zum Jahr 2035 fehlen nach neuesten Prognosen von Klemm (2022) in Deutschland ca. 127.000 Lehrkräfte. Diese große Lücke kann nicht mehr allein durch Lehrkräfte abge-deckt werden, die ein traditionelles Lehramtsstudium absolviert haben. Als Antwort auf den Lehrkräftemangel werden in Schulen in Deutschland daher vermehrt Personen ohne traditio-nelles Lehramtsstudium eingestellt, um die Unterrichtsversorgung zu gewährleisten (KMK, 2022). Nicht-traditionell ausgebildete Lehrkräfte durchlaufen vor ihrer Einstellung in den Schuldienst in der Regel ein alternatives Qualifizierungsprogramm. Diese Qualifizierungs-programme sind jedoch in ihrer zeitlichen und inhaltlichen Ausgestaltung sehr heterogen und setzen unterschiedliche Eingangsvoraussetzungen der Bewerber:innen voraus (Driesner & Arndt, 2020). Sie sind in der Regel jedoch deutlich kürzer als traditionelle Lehramtsstudien-gänge an Hochschulen und Universitäten, um einen schnellen Einstieg in den Schuldienst zu gewährleisten. Die kürzere Qualifizierung geht damit mit einer geringeren Anzahl an Lern- und Lehrgelegenheiten einher, wie sie in einem traditionellen Lehramtsstudium zu finden wäre. Infolgedessen kann davon ausgegangen werden, dass nicht-traditionell ausgebildete Lehrkräfte weniger gut auf die Anforderungen des Lehrberufs vorbereitet sind.
Diese Annahme wird auch oft in der Öffentlichkeit vertreten und die Kritik an alternati-ven Qualifizierungsprogrammen ist groß. So äußerte sich beispielsweise der Präsident des Deutschen Lehrerverbandes, Heinz-Peter Meidinger, im Jahr 2019 gegenüber der Zeitung „Die Welt“, dass die unzureichende Qualifizierung von Quereinsteiger:innen „ein Verbre-chen an den Kindern“ sei (Die Welt, 2019). Die Forschung im deutschsprachigen Raum, die in der Läge wäre, belastbare Befunde für die Unterstützung dieser Kritik liefern zu können, steht jedoch noch am Anfang. Erste Arbeiten weisen generell auf wenige Unterschiede zwi-schen traditionell und nicht-traditionell ausgebildeten Lehrkräften hin (Kleickmann & An-ders, 2011; Kunina-Habenicht et al., 2013; Oettinghaus, Lamprecht & Korneck, 2014). Ar-beiten, die Unterschiede finden, zeigen diese vor allem im Bereich des pädagogischen Wis-sens zuungunsten der nicht-traditionell ausgebildeten Lehrkräfte. Die Frage nach weiteren Unterschieden, beispielsweise in der Unterrichtsqualität oder im beruflichen Wohlbefinden, ist bislang jedoch für den deutschen Kontext nicht beantwortet worden.
Die vorliegende Arbeit hat zum Ziel, einen Teil dieser Forschungslücken zu schließen. Sie bearbeitet in diesem Zusammenhang im Rahmen von drei Teilstudien die Fragen nach Unterschieden zwischen traditionell und nicht-traditionell ausgebildeten Lehrkräften hin-sichtlich ihrer professionellen Kompetenz, Berufswahlmotivation, Wohlbefinden und Unter-richtsqualität. Die übergeordnete Fragestellung wird vor dem Hintergrund des theoretischen Modells zu den Determinanten und Konsequenzen der professionellen Kompetenz (Kunter, Kleickmann, Klusmann & Richter, 2011) bearbeitet. Dieses Modell wird auch für die theore-tische Aufarbeitung der bereits bestehenden nationalen und internationalen Forschungsarbei-ten zu Unterschieden zwischen traditionell und nicht-traditionell ausgebildeten Lehrkräften herangezogen.
Teilstudie I untersucht zunächst Unterschiede in der professionellen Kompetenz zwi-schen traditionell und nicht-traditionell ausgebildeten Lehrkräften. Nach dem Kompetenz-modell nach Baumert und Kunter (2006) werden die beiden Gruppen in den vier Aspekten professioneller Kompetenz – Professionswissen, Überzeugungen, motivationale Orientierun-gen und selbstregulative Fähigkeiten – verglichen. Im Fokus dieser Arbeit stehen traditionell ausgebildete Lehramtsanwärter:innen und die sogenannten Quereinsteiger:innen während des Vorbereitungsdiensts. Mittels multivariater Kovarianzanalysen wurde eine Sekundärdaten-analyse des Projekts COACTIV-R durchgeführt und Unterschiede analysiert.
Teilstudie II beleuchtet sowohl Determinanten als auch Konsequenzen professioneller Kompetenz. Auf Seiten der Determinanten werden Unterschiede in der Berufswahlmotivati-on zwischen Lehrkräften mit und ohne traditionellem Lehramtsstudium untersucht. Ferner erfolgt die Analyse von Unterschieden im beruflichen Wohlbefinden (emotionale Erschöp-fung, Enthusiasmus) und die Intention, im Beruf zu verbleiben, als Konsequenz professionel-ler Kompetenz. Es erfolgte eine Analyse der Daten aus der Pilotierungsstudie aus dem Jahr 2019 für den Bildungstrend des Instituts für Qualitätsentwicklung im Bildungswesen (IQB). Unterschiede zwischen traditionell und nicht-traditionell ausgebildeten Lehrkräften wurden erneut mittels multivariater Kovarianzanalysen berechnet.
Abschließend erfolgte in Teilstudie III die Untersuchung von Unterschieden in der Un-terrichtsqualität zwischen traditionell und nicht-traditionell ausgebildeten Lehrkräften als Konsequenz professioneller Kompetenz. Hierzu wurden Daten des IQB-Bildungstrends 2018 im Rahmen einer Sekundäranalyse mithilfe doppelt-latenter Mehrebenenanalysen genutzt. Es wurden die Unterschiede in den Bereichen Abwesenheit von Störungen, kognitive Akti-vierung und Schüler:innenunterstützung betrachtet.
Im finalen Kapitel der vorliegenden Arbeiten werden die zentralen Befunde der drei Teilstudien zusammengefasst und diskutiert. Die Ergebnisse weisen darauf hin, dass sich traditionell und nicht-traditionell ausgebildete Lehrkräfte nur in wenigen der untersuchten Aspekte signifikant voneinander unterscheiden. Nicht-traditionell ausgebildete Lehrkräfte verfügen über weniger pädagogisches Wissen, haben bessere selbstregulative Fähigkeiten und unterscheiden sich nicht in ihren Berufswahlmotiven, ihrem Wohlbefinden und in der Unterrichtsqualität von traditionell ausgebildeten Lehrkräften. Die Ergebnisse öffnen die Tür für die Diskussion der Relevanz des traditionellen Lehramtsstudiums, bieten eine Grundlage bzgl. der Implikationen für weiterführende Forschungsarbeiten und die Bildungspolitik. Die Arbeiten werden abschließend hinsichtlich ihrer Grenzen bewertet.
In Forschungsprogrammen werden zahlreiche Akteure mit unterschiedlichen Hintergründen und fachlichen Expertisen in Einzel- oder Verbundvorhaben vereint, die jedoch weitestgehend unabhängig voneinander durchgeführt werden. Vor dem Hintergrund, dass gesamtgesellschaftliche Herausforderungen wie die globale Erwärmung zunehmend disziplinübergreifende Lösungsansätze erfordern, sollten Vernetzungs- und Transferprozesse in Forschungsprogrammen stärker in den Fokus rücken. Mit der Implementierung einer Begleitforschung kann dieser Forderung Rechnung getragen werden. Begleitforschung unterscheidet sich in ihrer Herangehensweise und ihrer Zielvorstellung von den „üblichen“ Projekten und kann in unterschiedlichen theoretischen Reinformen auftreten. Verkürzt dargestellt agiert sie entweder (1) inhaltlich komplementär zu den jeweiligen Forschungsprojekten, (2) auf einer Metaebene mit Fokus auf die Prozesse im Forschungsprogramm oder (3) als integrierende, synthetisierende Instanz, für die die Vernetzung der Projekte im Forschungsprogramm sowie der Wissenstransfer von Bedeutung sind. Zwar sind diese Formen analytisch in theoretische Reinformen trennbar, in der Praxis ergibt sich in der Regel jedoch ein Mix aus allen dreien.
In diesem Zusammenhang schließt die vorliegende Dissertation als ergänzende Studie an bisherige Ansätze zum methodischen Handwerkszeug der Begleitforschung an und fokussiert auf folgende Fragestellungen: Auf welcher Basis kann die Vernetzung der Akteure in einem Forschungsprogramm durchgeführt werden, um diese effektiv zusammenzubringen? Welche weiteren methodischen Elemente sollten daran ansetzen, um einen Mehrwert zu generieren, der die Summe der Einzelergebnisse des Forschungsprogrammes übersteigt? Von welcher Art kann dann ein solcher Mehrwert sein und welche Rolle spielt dabei die Begleitforschung?
Das erste methodische Element bildet die Erhebung und Aufbereitung einer Ausgangsdatenbasis. Durch eine auf semantischer Analyse basierenden Verschlagwortung projektbezogener Texte lässt sich eine umfassende Datenbasis aus den Inhalten der Forschungsprojekte generieren. Die Schlagwörter werden dabei anhand eines kontrollierten Vokabulars in einem Schlagwortkatalog strukturiert. Parallel dazu werden sie wiederum den jeweiligen Projekten zugeordnet, wodurch diese thematische Merkmale erhalten. Um thematische Überschneidungen zwischen Forschungsprojekten sichtbar und interpretierbar zu machen, beinhaltet das zweite Element Ansätze zur Visualisierung. Dazu werden die Informationen in einen Netzwerkgraphen transferiert, der sowohl alle im Forschungsprogramm involvierten Projekte als auch die identifizierten Schlagwörter in Relation zueinander abbilden kann. So kann zum Beispiel sichtbar gemacht werden, welche Forschungsprojekte sich auf Basis ihrer Inhalte „näher“ sind als andere. Genau diese Information wird im dritten methodischen Element als Planungsgrundlage für unterschiedliche Veranstaltungsformate wie Arbeitstagungen oder Transferwerkstätten genutzt. Das vierte methodische Element umfasst die Synthesebildung. Diese gestaltet sich als Prozess über den gesamten Zeitraum der Zusammenarbeit zwischen Begleitforschung und den weiteren Forschungsprojekten hinweg, da in die Synthese unter anderem Zwischen-, Teil- und Endergebnisse der Projekte einfließen, genauso wie Inhalte aus den unterschiedlichen Veranstaltungen. Letztendlich ist dieses vierte Element auch das Mittel, um aus den integrierten und synthetisierten Informationen Handlungsempfehlungen für zukünftige Vorhaben abzuleiten.
Die Erarbeitung der methodischen Elemente erfolgte im laufenden Prozess des Begleitforschungsprojektes KlimAgrar, welches der vorliegenden Dissertation als Fallbeispiel dient und dessen Hintergründe in der Thematik Klimaschutz und Klimaanpassung in der Landwirtschaft im Text ausführlich erläutert werden.
Terminology is a critical instrument for each researcher. Different terminologies for the same research object may arise in different research communities. By this inconsistency, many synergistic effects get lost. Theories and models will be more understandable and reusable if a common terminology is applied. This paper examines the terminological (in)consistence for the research field of job-shop scheduling by a literature review. There is an enormous variety in the choice of terms and mathematical notation for the same concept. The comparability, reusability and combinability of scheduling methods is unnecessarily hampered by the arbitrary use of homonyms and synonyms. The acceptance in the community of used variables and notation forms is shown by means of a compliance quotient. This is proven by the evaluation of 240 scientific publications on planning methods.
Competence development must change at all didactic levels to meet the new requirements triggered by digitization. Unlike classic learning theories and the resulting popular approaches (e.g., sender-receiver model), future-oriented vocational training must include new learning theory impulses in the discussion about competence acquisition. On the one hand, these impulses are often very well elaborated on the theoretical side, but the transfer into innovative learning environments - such as learning factories - is often still missing. On the other hand, actual learning factory (design) approaches often concentrate primarily on the technical side. Subject-oriented learning theory enables the design of competence development-oriented vocational training projectsin learning factories in which persons can obtain relevant competencies for digitization. At the same time, such learning theory approaches assume a potentially infinite number of learning interests and reasons. Following this, competence development is always located in an institutional or organizational context. The paper conceptionally answers how this theoryimmanent challenge is synthesizable with the reality of organizationally competence development requirements.
Handbuch der ERP-Auswahl
(2023)
The authors propose that while tacit knowledge is a valuable resource for developing new business models, its externalization presents several challenges. One major challenge is that individuals often don’t recognize their tacit knowledge resources, while another is the reluctance to share one’s knowledge with others. Addressing these challenges, the authors present an application-oriented serious game-based haptic modeling approach for externalize tacit knowledge, which can be used to develop the first versions of business models based on tacit knowledge. Both conceptual and practical design fundamentals are presented based on elaborated theoretical approaches, which were developed with the help of a design science approach. The development of the research process is presented step by step, whereby we focused on the high accessibility of the presented research. Practitioners are presented with guidelines for implementing their serious game projects. Scientists benefit from starting points for their research topics of externalization, internalization, and socialization of tacit knowledge, development of business models, and serious games or gamification. The paper concludes with open research desiderata and questions from the presented research process.
Mit RASSCO siedeln
(2023)
Die Jeckes-Forschung hat sie übersehen, die Architekturgeschichte hat ihre Bauten ignoriert, ihre Emigration stand unter dem Stigma des "Pakts mit dem Teufel": die nach 1933 aus dem nationalsozialistischen Deutschen Reich emigrierten Juden, die im Rahmen der "Kapitalisten-Alija" nach Palästina gelangten und dort in Mittelstandsdörfern angesiedelt wurden. Organisiert wurde ihre Emigration durch die Baugesellschaft RASSCO, die 1934 im Zuge des Haavara-Abkommens für den Siedlungstransfer gegründet wurde. Bis Kriegsausbruch wurden verschiedene Siedlungen realisiert, darunter Kfar Schmarjahu und die "Siedlung der Württemberger" Schawej Zion, bis zur Staatsgründung rund zwei Dutzend. Ines Sonder und Joachim Trezib dokumentieren erstmals den gesamten Prozess der Übersiedlung von der politischen Dimension des Haavara-Transfers bis hin zu den Einzelschicksalen der Siedlerfamilien aus Deutschland. Sie eröffnen somit eine neue Perspektive auf die Fünfte Alija - durch ihr reiches, bislang unveröffentlichtes Bildmaterial auch in visueller Hinsicht.
Die Arbeit befasst sich mit der Vorgabe des Aachener Vertrages, welche mit der Schaffung des Deutsch-Französischen Bürgerfonds die Zivilgesellschaften der beiden Partnerländer und ihr weiteres Zusammenwachsen in den Fokus genommen haben. Hierzu wird auf die Frage eingegangen, warum eine weitere deutsch-französische Organisation gerade in diesen Zeiten notwendig ist und warum ihr durch Ausgestaltung als möglichst eigenständige Institution die erforderliche Rolle als beständiger Motor für eine notwendige weitere Europäisierung zuteilwerden kann.
Der Bürgerfonds soll mithilfe seiner finanziellen Unterstützungsleistungen des binationalen Austausches von Bürgerinitiativen, Stiftungen, Kulturzentren, Vereinen, Städtepartnerschaften und sonstigen Formen privaten Engagements als „Leuchtturmprojekt des Aachener Vertrages“ diejenigen ansprechen, welche bislang nicht als klassische stakeholder der deutsch-französischen Freundschaft bekannt geworden sind.
Die Ausgestaltung des Bürgerfonds als eigenständige internationale Organisation erscheint vor dem Hintergrund dieser Zielsetzung die optimale Rechtsform. Seine generelle Aufbauorganisation sollte an der des Deutsch-Französischen Jugendwerks angelehnt werden. Insoweit war die Vorgabe der organisatorischen Einbindung des Bürgerfonds in das Jugendwerk im Rahmen der Pilotphase bis Ende 2022 nicht nur wegen der dort vorhandenen großen Expertise eine sinnvolle Entscheidung des Deutsch-Französischen Ministerrats.
Eine Erweiterung des Verwaltungs- bzw. Kontrollgremiums in einem selbständigen Bürgerfonds durch Vertreter der Deutsch-Französischen Parlamentarischen Versammlung erscheint zur Gewährleistung von Transparenz und tagespolitischer Unabhängigkeit ebenso ratsam, wie seine zumindest partielle Öffnung für andere europäische Mitgliedsstaaten.
Abschließend bleibt zu konstatieren, dass in den Zeiten kriselnder Demokratien und der COVID-Gefahr eine Hinwendung zu den Bürgern und ihren privaten bzw. para-öffentlichen Organisationsformen ebenso wichtig ist, wie die Förderung des Austausches der Bürger beider Länder im Herzen Europas mehr denn je hilft, Distanzen zu überwinden und transnationale Gemeinschaft zu erleben.
Creative intensive processes
(2023)
Creativity – developing something new and useful – is a constant challenge in the working world. Work processes, services, or products must be sensibly adapted to changing times. To be able to analyze and, if necessary, adapt creativity in work processes, a precise understanding of these creative activities is necessary. Process modeling techniques are often used to capture business processes, represent them graphically and analyze them for adaptation possibilities. This has been very limited for creative work. An accurate understanding of creative work is subject to the challenge that, on the one hand, it is usually very complex and iterative. On the other hand, it is at least partially unpredictable as new things emerge. How can the complexity of creative business processes be adequately addressed and simultaneously manageable? This dissertation attempts to answer this question by first developing a precise process understanding of creative work. In an interdisciplinary approach, the literature on the process description of creativity-intensive work is analyzed from the perspective of psychology, organizational studies, and business informatics. In addition, a digital ethnographic study in the context of software development is used to analyze creative work. A model is developed based on which four elementary process components can be analyzed: Intention of the creative activity, Creation to develop the new, Evaluation to assess its meaningfulness, and Planning of the activities arising in the process – in short, the ICEP model. These four process elements are then translated into the Knockledge Modeling Description Language (KMDL), which was developed to capture and represent knowledge-intensive business processes. The modeling extension based on the ICEP model enables creative business processes to be identified and specified without the need for extensive modeling of all process details. The modeling extension proposed here was developed using ethnographic data and then applied to other organizational process contexts. The modeling method was applied to other business contexts and evaluated by external parties as part of two expert studies. The developed ICEP model provides an analytical framework for complex creative work processes. It can be comprehensively integrated into process models by transforming it into a modeling method, thus expanding the understanding of existing creative work in as-is process analyses.
Zahlen in den Fingern
(2023)
Die Debatte über den Einsatz von digitalen Werkzeugen in der mathematischen Frühförderung ist hoch aktuell. Lernspiele werden konstruiert, mit dem Ziel, mathematisches, informelles Wissen aufzubauen und so einen besseren Schulstart zu ermöglichen. Doch allein die digitale und spielerische Aufarbeitung führt nicht zwingend zu einem Lernerfolg. Daher ist es umso wichtiger, die konkrete Implementation der theoretischen Konstrukte und Interaktionsmöglichkeiten mit den Werkzeugen zu analysieren und passend aufzubereiten.
In dieser Masterarbeit wird dazu exemplarisch ein mathematisches Lernspiel namens „Fingu“ für den Einsatz im vorschulischen Bereich theoretisch und empirisch im Rahmen der Artifact-Centric Activity Theory (ACAT) untersucht. Dazu werden zunächst die theoretischen Hintergründe zum Zahlensinn, Zahlbegriffserwerb, Teil-Ganze-Verständnis, der Anzahlwahrnehmung und -bestimmung, den Anzahlvergleichen und der Anzahldarstellung mithilfe von Fingern gemäß der Embodied Cognition sowie der Verwendung von digitalen Werkzeugen und Multi-Touch-Geräten umfassend beschrieben. Anschließend wird die App Fingu erklärt und dann theoretisch entlang des ACAT-Review-Guides analysiert. Zuletzt wird die selbstständig durchgeführte Studie mit zehn Vorschulkindern erläutert und darauf aufbauend Verbesserungs- und Entwicklungsmöglichkeiten der App auf wissenschaftlicher Grundlage beigetragen. Für Fingu lässt sich abschließend festhalten, dass viele Prozesse wie die (Quasi-)Simultanerfassung oder das Zählen gefördert werden können, für andere wie das Teil-Ganze-Verständnis aber noch Anpassungen und/oder die Begleitung durch Erwachsene nötig ist.
Development of self-concept and task interest has been shown to be affected by social comparison processes in a variety of cross-sectional studies. A potential explanation for these effects is an effect of social comparative performance feedback on an individual’s self-evaluation of performance, which in turn influences development of self-concept and task interest. There are, however, only few studies addressing this topic with experimental designs. This study was aimed at closing this research gap by experimentally manipulating social comparative performance. Feedback given was based on 2 × 2 experimental conditions: social position (high vs. low) and average performance of the reference group (high vs. low). Results show a strong effect of social position on self-evaluation of performance and smaller effects on self-concept and task interest.
Defining the metaverse
(2023)
The term Metaverse is emerging as a result of the late push by multinational technology conglomerates and a recent surge of interest in Web 3.0, Blockchain, NFT, and Cryptocurrencies. From a scientific point of view, there is no definite consensus on what the Metaverse will be like. This paper collects, analyzes, and synthesizes scientific definitions and the accompanying major characteristics of the Metaverse using the methodology of a Systematic Literature Review (SLR). Two revised definitions for the Metaverse are presented, both condensing the key attributes, where the first one is rather simplistic holistic describing “a three-dimensional online environment in which users represented by avatars interact with each other in virtual spaces decoupled from the real physical world”. In contrast, the second definition is specified in a more detailed manner in the paper and further discussed. These comprehensive definitions offer specialized and general scholars an application within and beyond the scientific context of the system science, information system science, computer science, and business informatics, by also introducing open research challenges. Furthermore, an outlook on the social, economic, and technical implications is given, and the preconditions that are necessary for a successful implementation are discussed.
Many widely used observational data sets are comprised of several overlapping instrument records. While data inter-calibration techniques often yield continuous and reliable data for trend analysis, less attention is generally paid to maintaining higher-order statistics such as variance and autocorrelation. A growing body of work uses these metrics to quantify the stability or resilience of a system under study and potentially to anticipate an approaching critical transition in the system. Exploring the degree to which changes in resilience indicators such as the variance or autocorrelation can be attributed to non-stationary characteristics of the measurement process – rather than actual changes in the dynamical properties of the system – is important in this context. In this work we use both synthetic and empirical data to explore how changes in the noise structure of a data set are propagated into the commonly used resilience metrics lag-one autocorrelation and variance. We focus on examples from remotely sensed vegetation indicators such as vegetation optical depth and the normalized difference vegetation index from different satellite sources. We find that time series resulting from mixing signals from sensors with varied uncertainties and covering overlapping time spans can lead to biases in inferred resilience changes. These biases are typically more pronounced when resilience metrics are aggregated (for example, by land-cover type or region), whereas estimates for individual time series remain reliable at reasonable sensor signal-to-noise ratios. Our work provides guidelines for the treatment and aggregation of multi-instrument data in studies of critical transitions and resilience.
Many widely used observational data sets are comprised of several overlapping instrument records. While data inter-calibration techniques often yield continuous and reliable data for trend analysis, less attention is generally paid to maintaining higher-order statistics such as variance and autocorrelation. A growing body of work uses these metrics to quantify the stability or resilience of a system under study and potentially to anticipate an approaching critical transition in the system. Exploring the degree to which changes in resilience indicators such as the variance or autocorrelation can be attributed to non-stationary characteristics of the measurement process – rather than actual changes in the dynamical properties of the system – is important in this context. In this work we use both synthetic and empirical data to explore how changes in the noise structure of a data set are propagated into the commonly used resilience metrics lag-one autocorrelation and variance. We focus on examples from remotely sensed vegetation indicators such as vegetation optical depth and the normalized difference vegetation index from different satellite sources. We find that time series resulting from mixing signals from sensors with varied uncertainties and covering overlapping time spans can lead to biases in inferred resilience changes. These biases are typically more pronounced when resilience metrics are aggregated (for example, by land-cover type or region), whereas estimates for individual time series remain reliable at reasonable sensor signal-to-noise ratios. Our work provides guidelines for the treatment and aggregation of multi-instrument data in studies of critical transitions and resilience.
Development of self-concept and task interest has been shown to be affected by social comparison processes in a variety of cross-sectional studies. A potential explanation for these effects is an effect of social comparative performance feedback on an individual’s self-evaluation of performance, which in turn influences development of self-concept and task interest. There are, however, only few studies addressing this topic with experimental designs. This study was aimed at closing this research gap by experimentally manipulating social comparative performance. Feedback given was based on 2 × 2 experimental conditions: social position (high vs. low) and average performance of the reference group (high vs. low). Results show a strong effect of social position on self-evaluation of performance and smaller effects on self-concept and task interest.
The retention of actinides in different oxidation states (An(X), X = III, IV, VI) by a calcium-silicate-hydrate (C-S-H) phase with a Ca/Si (C/S) ratio of 0.8 was investigated in the presence of gluconate (GLU). The actinides considered were Am(III), Th(IV), Pu(IV), and U(VI). Eu(III) was investigated as chemical analogue for Am(III) and Cm(III). In addition to the ternary systems An(X)/GLU/C-S-H, also binary systems An(X)/C-S-H, GLU/C-S-H, and An(X)/GLU were studied. Complementary analytical techniques were applied to address the different specific aspects of the binary and ternary systems. Time-resolved laser-induced luminescence spectroscopy (TRLFS) was applied in combination with parallel factor analysis (PARAFAC) to identify retained species and to monitor species-selective sorption kinetics. ¹³C and ²⁹Si magic-angle-spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy and X-ray photoelectron spectroscopy (XPS) were applied to determine the bulk structure and the composition of the C-S-H surface, respectively, in the absence and presence of GLU. The interaction of Th(IV) with GLU in different electrolytes was studied by capillary electrophoresis-inductively coupled plasma mass spectrometry (CE-ICP-MS). The influence of GLU on An(X) retention was investigated for a large concentration range up to 10⁻² M. The results showed that GLU had little to no effect on the overall An(X) retention by C-S-H with C/S of 0.8, regardless of the oxidation state of the actinides. For Eu(III), the TRLFS investigations additionally implied the formation of a Eu(III)-bearing precipitate with dissolved constituents of the C-S-H phase, which becomes structurally altered by the presence of GLU. For U(VI) sorption on the C-S-H phase, only a small influence of GLU could be established in the luminescence spectroscopic investigations, and no precipitation of U(VI)-containing secondary phases could be identified.
The retention of actinides in different oxidation states (An(X), X = III, IV, VI) by a calcium-silicate-hydrate (C-S-H) phase with a Ca/Si (C/S) ratio of 0.8 was investigated in the presence of gluconate (GLU). The actinides considered were Am(III), Th(IV), Pu(IV), and U(VI). Eu(III) was investigated as chemical analogue for Am(III) and Cm(III). In addition to the ternary systems An(X)/GLU/C-S-H, also binary systems An(X)/C-S-H, GLU/C-S-H, and An(X)/GLU were studied. Complementary analytical techniques were applied to address the different specific aspects of the binary and ternary systems. Time-resolved laser-induced luminescence spectroscopy (TRLFS) was applied in combination with parallel factor analysis (PARAFAC) to identify retained species and to monitor species-selective sorption kinetics. ¹³C and ²⁹Si magic-angle-spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy and X-ray photoelectron spectroscopy (XPS) were applied to determine the bulk structure and the composition of the C-S-H surface, respectively, in the absence and presence of GLU. The interaction of Th(IV) with GLU in different electrolytes was studied by capillary electrophoresis-inductively coupled plasma mass spectrometry (CE-ICP-MS). The influence of GLU on An(X) retention was investigated for a large concentration range up to 10⁻² M. The results showed that GLU had little to no effect on the overall An(X) retention by C-S-H with C/S of 0.8, regardless of the oxidation state of the actinides. For Eu(III), the TRLFS investigations additionally implied the formation of a Eu(III)-bearing precipitate with dissolved constituents of the C-S-H phase, which becomes structurally altered by the presence of GLU. For U(VI) sorption on the C-S-H phase, only a small influence of GLU could be established in the luminescence spectroscopic investigations, and no precipitation of U(VI)-containing secondary phases could be identified.
Defining the metaverse
(2023)
The term Metaverse is emerging as a result of the late push by multinational technology conglomerates and a recent surge of interest in Web 3.0, Blockchain, NFT, and Cryptocurrencies. From a scientific point of view, there is no definite consensus on what the Metaverse will be like. This paper collects, analyzes, and synthesizes scientific definitions and the accompanying major characteristics of the Metaverse using the methodology of a Systematic Literature Review (SLR). Two revised definitions for the Metaverse are presented, both condensing the key attributes, where the first one is rather simplistic holistic describing “a three-dimensional online environment in which users represented by avatars interact with each other in virtual spaces decoupled from the real physical world”. In contrast, the second definition is specified in a more detailed manner in the paper and further discussed. These comprehensive definitions offer specialized and general scholars an application within and beyond the scientific context of the system science, information system science, computer science, and business informatics, by also introducing open research challenges. Furthermore, an outlook on the social, economic, and technical implications is given, and the preconditions that are necessary for a successful implementation are discussed.
Using time-resolved x-ray diffraction, we demonstrate the manipulation of the picosecond strain response of a metallic heterostructure consisting of a dysprosium (Dy) transducer and a niobium (Nb) detection layer by an external magnetic field. We utilize the first-order ferromagnetic–antiferromagnetic phase transition of the Dy layer, which provides an additional large contractive stress upon laser excitation compared to its zerofield response. This enhances the laser-induced contraction of the transducer and changes the shape of the picosecond strain pulses driven in Dy and detected within the buried Nb layer. Based on our experiment with rare-earth metals we discuss required properties for functional transducers, which may allow for novel field-control of the emitted picosecond strain pulses.
Mehr als nur Ehefrauen
(2023)