Refine
Has Fulltext
- yes (249)
Year of publication
- 2017 (249) (remove)
Document Type
- Postprint (249) (remove)
Is part of the Bibliography
- yes (249) (remove)
Keywords
- climate (9)
- Germany (5)
- Längsschnittstudie (4)
- Mannheim Study of Children at Risk (4)
- Mannheimer Risikokinderstudie (4)
- ancient DNA (4)
- longitudinal study (4)
- model (4)
- transport (4)
- variability (4)
- young athletes (4)
- alignment (3)
- biomineralization (3)
- children (3)
- climate change (3)
- damage (3)
- elderly (3)
- exercise (3)
- gait (3)
- models (3)
- molecularly imprinted polymers (3)
- networks (3)
- precipitation (3)
- preferential flow (3)
- preparedness (3)
- reliability (3)
- scale (3)
- surface (3)
- time (3)
- Arabidopsis (2)
- Holocene (2)
- Japan (2)
- SRTM (2)
- Tibetan Plateau (2)
- adolescence (2)
- aging (2)
- assessment (2)
- august 2002 (2)
- back pain (2)
- brushite (2)
- calcium phosphate (2)
- carbon (2)
- change detection (2)
- childhood (2)
- collapse (2)
- construct validity (2)
- crystal structure (2)
- diffusion (2)
- dynamics (2)
- embodied cognition (2)
- erosion (2)
- field (2)
- force production (2)
- genome sequence (2)
- hyperspectral (2)
- imaging spectroscopy (2)
- inflammation (2)
- kidney transplantation (2)
- lake (2)
- learning styles (2)
- obesity (2)
- ocean (2)
- osteoporosis (2)
- oxidative stress (2)
- photochemistry (2)
- phylogeography (2)
- rainfall (2)
- raman-scattering (2)
- reanalysis (2)
- recovery (2)
- risk factors (2)
- sentence comprehension (2)
- social rejection (2)
- soil moisture (2)
- solute transport (2)
- sonography (2)
- spectroscopy (2)
- states (2)
- system (2)
- temperature (2)
- topography (2)
- tracer (2)
- victim blame (2)
- wh-in-situ (2)
- working memory (2)
- "Little Ice Age' (LIA) (1)
- "Medieval Warm Period' (MWP) (1)
- 1,2-dithiooxalate (1)
- 1.5 degrees C (1)
- 1988 Saguenay (1)
- 1994 Northridge (1)
- 2008 Wenchuan earthquake (1)
- 2010 Haiti earthquake (1)
- 2016-origin (1)
- 2nd langauge (1)
- 2nd-language acquisition (1)
- A. tenuissima (1)
- ADHD (1)
- APC concentration gradient (1)
- ASI-3 (1)
- Accelerometer (1)
- Achilles and patellar tendon (1)
- Acids (1)
- Actin cytoskeleton (1)
- Adaptive Force (1)
- Adolescence (1)
- Affiliation (1)
- African elephants (1)
- Aftercare (1)
- AgroScapeLabs (1)
- Ailuropoda melanoleuca (1)
- Akan (1)
- Alternaria infectoria (1)
- Alternaria toxin sulfates (1)
- Anxiety Sensitivity Index (1)
- Aphis fabae (1)
- Apoptosis (1)
- Arabidopsis-thaliana (1)
- Archaea (1)
- Arctic vegetation (1)
- Aridity (1)
- Asian American studies (1)
- Asymmetric interlaced PCR (1)
- Athlete testing (1)
- Athletes (1)
- Atlantic studies (1)
- Atlantic-Ocean (1)
- Auger electron spectroscopy (1)
- Australia (1)
- Back pain diagnosis (1)
- Back pain prognosis (1)
- Bacteria (1)
- Bacteriophage (1)
- Bayes factor (1)
- Bayesian standard ellipse (1)
- Bibliometrie (1)
- Biomarker (1)
- Black Pacific (1)
- Blood (1)
- Brachypodium distachyon (1)
- Brachypodium hybridum (1)
- Brachypodium stacei (1)
- Brassicaceae (1)
- C-asterisk-algebra (1)
- C-reactive protein (1)
- C. bonducella (1)
- CM(-1) (1)
- CMIP5 (1)
- CMS (1)
- CO2 (1)
- CO2 fluxes (1)
- Calorimetry (1)
- Camelus dromedarius (1)
- Catchment Hydrology (1)
- Cattle (1)
- Cell polarity (1)
- Central Asia (1)
- Central Europe (1)
- Central Great-Plains (1)
- Child Behavior Checklist-Dysregulation Profile (1)
- Child Behavior Checklist-Dysregulationsprofil (1)
- Complementarity (1)
- Countermovement jump (1)
- Cow-side assay (1)
- Cyanobacteria (1)
- D. melleri (1)
- DELLA (1)
- DEM uncertainty (1)
- DNA (1)
- DNA Elements (1)
- DNA metabarcoding (1)
- DNA methylation (1)
- Daphnia (1)
- Database (1)
- Dickkopf diffusion and feedback regulation (1)
- Dietary assessment (1)
- Dietary questionnaires (1)
- Dietary recalls (1)
- Digestive enzyme activity (1)
- Donors (1)
- Donovani (1)
- Dronning Maud Land (1)
- Drug delivery (1)
- Dryas cold period (1)
- E. schliebenii (1)
- ECG (1)
- EDTA (1)
- EEG (1)
- EROEI (1)
- Eastern Continental Asia (1)
- Elternverhalten (1)
- EnGeoMAP 2.0 (1)
- EnMAP (1)
- Energy requirement (1)
- Entwicklung (1)
- Entwicklungspsychopathologie (1)
- Epidemiologic studies (1)
- Epigenetics (1)
- Epithelial tube (1)
- Escherichia-coli (1)
- Eukaryota (1)
- Europa (1)
- European Union (1)
- Evapotranspiration (1)
- Exercise (1)
- Exercise therapy (1)
- Exocrine gland (1)
- FAP (1)
- Fat-free mass (1)
- Feedback (1)
- Fen complex (1)
- Field test (1)
- Flow cytometry (1)
- Food frequency questionnaire (1)
- Food intake (1)
- Forest-savannah (1)
- Formate (1)
- Frühgeburt (1)
- GATI (1)
- GMPE (1)
- German (1)
- Geschichte Italiens im 20. Jahrhundert (1)
- Gestational diabetes (1)
- Ginkgo biloba extract (1)
- Global DNA methylation (1)
- Global Vegetation Model (1)
- Graphic Assessment of TPACK Instrument (1)
- Greenland ice-core (1)
- Ground Penetrating Radar (1)
- H. pubescens (1)
- HPLC-MS/MS (1)
- Hamiltonella defensa (1)
- Holding isometric muscle action (1)
- Holocene climate change (1)
- Home-based (1)
- HySpex (1)
- Hyperion (1)
- Hypermethylation (1)
- IMPRESSIONS (1)
- Ice core records (1)
- India (1)
- Injury (1)
- Inner Mongolia (1)
- Insect (1)
- Insulin resistance (1)
- Invagination (1)
- Iron Gates (1)
- Isabella Bird (1)
- Israel (1)
- Italian (1)
- IκB (1)
- JUB1 (1)
- Job Demands Resources Theory (1)
- Kalman filter (1)
- Kardinal Franz Ehrle (1)
- KiK-net (1)
- Kohnen Station (1)
- LANDSAT (1)
- LC-MS/MS (1)
- Lake Suigetsu (1)
- Lake sediments (1)
- Large-scale studies on food intake (1)
- Last Glacial Maximum (1)
- Lateranverträge 1929 (1)
- Lena River delta (1)
- Lipases (1)
- Lower-extremity muscle power (1)
- Lysiphlebus fabarum (1)
- MNDWI (1)
- Mechanomyography (1)
- Mechanotendography (1)
- Mediterranean grass species (1)
- Method comparison (1)
- Microtus arvalis (1)
- Migration (1)
- Mitochondrial-DNA analysis (1)
- Mode function (1)
- Morocco (1)
- Mozambique belt (1)
- Muntjac (1)
- Mutter-Kind-Interaktion (1)
- Myodes glareolus (1)
- Myodes voles (1)
- NAO (1)
- NCOP (1)
- NDVI (1)
- NE Siberia (1)
- NEG (1)
- NF-κB (1)
- NM (1)
- NTA (1)
- Neotropics (1)
- Netherlands (1)
- Neuroenhancement (1)
- Niger River (1)
- Non-fluent aphasia (1)
- North Atlantic (1)
- North Central region (1)
- Northern Kenya (1)
- Nutritional counseling (1)
- Nutritional quality (1)
- O-antigen (1)
- O-serotyping (1)
- OBIA (1)
- Organ Groth (1)
- Organogenesis (1)
- Output-Analyse (1)
- PMIP2 coupled simulations (1)
- PROGRESS/TRIPOD (1)
- PTH (1)
- Pacific studies (1)
- Pain occurrence (1)
- Pain screening (1)
- Palaeoloxodon-antiquus (1)
- Palaeotropics (1)
- Palynology (1)
- Pathological Narcissism Inventory (1)
- Persia (1)
- Phase variation (1)
- Philippine archipelago (1)
- Photochemie (1)
- Phylogeny (1)
- Pinus pinaster (1)
- Place (1)
- Placenta (1)
- Plants (1)
- Pleistocene (1)
- Podanthus mitiqui (1)
- Polish speaking immigrants in Germany (1)
- Politics of childhood (1)
- Pollen trap (1)
- Postpartale Depression (1)
- Prediction of disability/intensity (1)
- Protonierung (1)
- Psychosoziales Risiko (1)
- Psychotherapeutische Ausbildung (1)
- Psychotherapeutische Kompetenzen (1)
- Psychotherapie (1)
- Pushing isometric muscle action (1)
- Puumala virus seroprevalence (1)
- Qualitative Inhaltsanalyse (1)
- Quantum optics (1)
- Quercus ilex (1)
- Quercus pubescens (1)
- RIXS (resonant inelastic X-ray scattering) (1)
- RIXS (resonante inelastische Röntgenstreuung) (1)
- Raman-Lidar (1)
- Rattus norvegicus (1)
- Rattus rattus (1)
- Raumtheorie (1)
- Review (1)
- Risikofaktoren (1)
- Risikoforschung (1)
- Romania (1)
- Russia (1)
- Römische Frage (1)
- SD3 (1)
- SELEX (1)
- SEMG-pattern (1)
- SWIM (1)
- Sahel (1)
- Salmonella Typhimurium (1)
- Salts (1)
- Samara (1)
- Savanna (1)
- Schutzfaktoren (1)
- Selektiver Bindungsbruch (1)
- Size (1)
- South-Asia (1)
- Southeast Asia (1)
- Southern-Hemisphere (1)
- Squat jump (1)
- Standard Indonesian (1)
- Statistical modelling (1)
- Stickstoff (1)
- Supervision (1)
- System (1)
- TPACK (1)
- Tailspike protein (1)
- Taylor’s law (1)
- Telerehabilitation (1)
- Teteriv (1)
- Topologie (1)
- Total hip replacement (1)
- Total knee replacement (1)
- Training volume (1)
- Transpacific studies (1)
- Turkish-German bilingualism (1)
- Two forms of isometric muscle action (1)
- Ukraine (1)
- United States (1)
- Vacuum fields (1)
- Vatikanstaat (1)
- Vitamin A (1)
- West African monsoon (1)
- West Antarctica (1)
- Western Bug (1)
- Wicked problems (1)
- Wnt/ β-catenin signalling pathway (1)
- WorldView-2 (1)
- Yellow flags (1)
- Young athletes (1)
- Younger Dryas (1)
- Zipf’s law (1)
- abrupt monsoon transitions (1)
- abstract concepts (1)
- academic failure (1)
- acceleration (1)
- accountability (1)
- accountability dynamics (1)
- accountability mechanism (1)
- acculturation (1)
- acquired thermotolerance (1)
- action words (1)
- adaptation (1)
- adipogenesis (1)
- adipose tissue dysregulation (1)
- administration (1)
- admixture (1)
- adolescent immigrants (1)
- adolescents (1)
- aerosol optical-properties (1)
- affect (1)
- affected residents (1)
- affective (1)
- affiliation (1)
- age models (1)
- aggressive peers (1)
- agricultural landscapes (1)
- agriculture (1)
- agroecosystem (1)
- air-pollution transport (1)
- alcohol (1)
- aleatory variability (1)
- algorithms (1)
- alleles (1)
- alpine catchments (1)
- altenuic acid (1)
- altertoxins (1)
- amorphous silica (1)
- amphibians (1)
- amplification (1)
- ancient (1)
- ancient DNA (aDNA) (1)
- animacy (1)
- animal personality (1)
- anniversary issue (1)
- antecedent complexity (1)
- anterior knee pain (1)
- anti-oxidative response (1)
- antioxidants (1)
- antiplasmodial (1)
- anxiety sensitivity (1)
- aphids (1)
- aptamers (1)
- aptasensors (1)
- aquatic macrophytes (1)
- archipelagic studies (1)
- archival DNA (1)
- aspect ratio (1)
- associative (1)
- asylum (1)
- atherosclerosis (1)
- athmosphere (1)
- atmospheric nitrogen deposition (1)
- atopic dermatitis (1)
- attraction (1)
- auger spectrum (1)
- autologous chondrocyte implantation (1)
- automatic evaluation (1)
- azobenzene containing polymer films (1)
- backscatter lidar (1)
- bacterioplankton (1)
- basal mechanics (1)
- basin (1)
- behavioural type (1)
- beta-diversity (1)
- bibliometrics (1)
- bilingual aphasia (1)
- biobanks (1)
- biochemical cycle (1)
- biodegradable polymers (1)
- biodiversity exploratories (1)
- bioelectrocatalysis (1)
- bioenergy (1)
- biofuel (1)
- biogeography (1)
- biological control (1)
- biomaterial (1)
- biomaterials (1)
- biomechanics (1)
- biomimetic mineralization (1)
- biomimetic recognition elements (1)
- bird (1)
- birds (1)
- birth weight (1)
- black carbon (1)
- bleach (1)
- blood glucose (1)
- bone tissue engineering (1)
- bones (1)
- bone–brain–nervous system interactions (1)
- boundary-layer (1)
- breeding strategies (1)
- brook experimental forest (1)
- bucerotidae (1)
- building damage (1)
- burnout (1)
- caecilians (1)
- caffeine (1)
- cancer cachexia (1)
- capture enrichment (1)
- carbon isotopes (1)
- cardiac rehabilitation (1)
- cardioverter-defibrillator (1)
- cartilage defect (1)
- cartilage repair (1)
- catchment (1)
- cell transplantation (1)
- cellulose (1)
- cenozoic Turkana depression (1)
- central Mediterranean (1)
- chain length distribution (1)
- chamber system (1)
- chaoborus kairomone (1)
- chemical sensors (1)
- chemistry (1)
- child asylum-seekers (1)
- chimeric transcription factors (1)
- chronic low back pain (1)
- chronic renal failure (1)
- chronic renal failure in children (1)
- chronic stress (1)
- circular dichroism (1)
- circulation (1)
- circulation patterns (1)
- cities and regions (1)
- city clusters (1)
- civil service (1)
- climate change impact (1)
- climate policy (1)
- climate reconstructions (1)
- climate variability (1)
- climate varibility (1)
- climate-change (1)
- clinical pain research (1)
- clinical sample (1)
- clinical supervision (1)
- cluster-analysis (1)
- co-limitation (1)
- co-monomer content (1)
- coastal flood damage (1)
- code generation (1)
- coexistence (1)
- cognitive behavioral intervention (1)
- cognitive development (1)
- cognitive enhancer (1)
- cognitive patterns (1)
- cognitive training (1)
- cognitive-postural dual task (1)
- cognitive/motor interference (1)
- coherence (1)
- collaborative work (1)
- collective intelligence (1)
- colonialism (1)
- common vole (1)
- community (1)
- complex problems (1)
- complex rupture (1)
- complexes (1)
- computer science (1)
- computer-assisted self-regulation training (1)
- concerted evolution (1)
- conservation (1)
- conservation genetics (1)
- consistency (1)
- contamination (1)
- continental lithosphere (1)
- continuous glucose monitoring (1)
- cooperation (1)
- covariance (1)
- creep stability (1)
- criminology (1)
- critical meteorological condition (1)
- cross-cultural comparison (1)
- crowding (1)
- crustal structure (1)
- cultural diversity (1)
- cultural pluralism (1)
- cylindrical geometry (1)
- cytotype (1)
- d-loop region (1)
- dead Cas9 (1)
- decision tree (1)
- deep learning (1)
- defense (1)
- defensive symbiosis (1)
- definition (1)
- degraded DNA (1)
- delta-D values (1)
- dementia (1)
- denali fault (1)
- dermal delivery (1)
- design options (1)
- design parameters (1)
- desynchronization (1)
- developing brain (1)
- development (1)
- developmental psychopathology (1)
- diabetes (1)
- digital elevation model (1)
- dioxide exchange (1)
- dip test (1)
- direct electron transfer (1)
- disability (1)
- discounting (1)
- dissociation kinetics (1)
- dissolution (1)
- dogs (1)
- drainage basins (1)
- driven (1)
- drop jump (1)
- drought (1)
- drug-delivery (1)
- dual-process (1)
- dual-task (1)
- duplication (1)
- duration of gestation (1)
- dyslexia (1)
- dyslexia assessment (1)
- early adversity (1)
- early parent-child relationship (1)
- early sport specialization (1)
- early warning (1)
- east-african rift (1)
- echocardiography (1)
- economics (1)
- ecosystem service (1)
- edar (1)
- eddy covariance (1)
- effort code (1)
- electronic-structure (1)
- elevated CO2 (1)
- elite athletes (1)
- ellipsis processing (1)
- emergency response (1)
- emission (1)
- emotion recognition (1)
- emotional expression (1)
- endocrine pathways (1)
- endogenous content (1)
- eneolithic (1)
- energy efficiency (1)
- english (1)
- ensemble (1)
- environmental DNA (1)
- environmental changes (1)
- environmental policy (1)
- enzymatic MIP synthesis (1)
- enzymatic analyte conversion (1)
- enzyme tracer (1)
- equality and inclusion (1)
- equation (1)
- error (1)
- european bat species (1)
- evaluation (1)
- evaporite minerals (1)
- event coincidence analysis (1)
- events (1)
- evolutionary history (1)
- exchange (1)
- executive function (1)
- expectations (1)
- experience (1)
- exposition (1)
- extreme flood (1)
- extremes (1)
- fMRI (1)
- face morphing (1)
- facial feedback (1)
- factor structure (1)
- family relations (1)
- fast dissociation (1)
- fat (1)
- feedback (1)
- female (1)
- fen (1)
- fertilization (1)
- fetus (1)
- field theory (1)
- field-scale (1)
- financial time series (1)
- fire history (1)
- first passage time (1)
- flash floods (1)
- flood adaptation (1)
- flood mitigation (1)
- flood-affected residents (1)
- floodplain (1)
- flow (1)
- flow-duration curves (1)
- fluctuating surfaces (1)
- fluorescence lifetime imaging microscopy (1)
- fluorescent dyemonomers (1)
- forest-fire smoke (1)
- forested headwater catchment (1)
- frailty (1)
- framework (1)
- free amino-acids (1)
- frequency analysis (1)
- freshwater (1)
- fricative (1)
- frozen sediments (1)
- frühe Eltern-Kind-Beziehung (1)
- fuel (1)
- function (1)
- fundamental movement skill (1)
- fur (1)
- gamma-ray bursts (1)
- gas-exchange (1)
- gas-production (1)
- gender (1)
- gene (1)
- gene expression (1)
- gene order (1)
- gene-expression (1)
- genetic diversity loss (1)
- genetics (1)
- genome-wide association study (1)
- genotype (1)
- geometric Brownian motion (1)
- geomorphometry (1)
- germacrane sesquiterpene lactone (1)
- giant panda (1)
- global sensitivity analysis (1)
- glomerular filtration rate (1)
- glycogen phosphorylation (1)
- governance (1)
- grade skipping (1)
- gratton effect (1)
- gravity (1)
- gravity measurements (1)
- green growth (1)
- ground-penetrating radar (1)
- grounding-line migration (1)
- growth (1)
- habitat use (1)
- hazards (1)
- healthy lifestyle (1)
- heart failure (1)
- hemodialysis (1)
- heteroplasmy (1)
- heterotrophic bacteria (1)
- heuristics and biases (1)
- high effect size (1)
- high resolution paleoclimatology (1)
- high-density lipoprotein (HDL) (1)
- high-intensity industrialized agricultural production systems (1)
- high-resolution record (1)
- hillslopes (1)
- hip (1)
- hip fracture (1)
- holmium(III) (1)
- hospitals (1)
- humanitarianism (1)
- humid forest (1)
- hybrid systems (1)
- hydraulic conductivity (1)
- hydraulic properties (1)
- hydroclimatology (1)
- hydrogels (1)
- hydrogen peroxide (1)
- hydrogen-isotopic composition (1)
- hydrologic-response simulation (1)
- hydrological modeling (1)
- hydrological modelling (1)
- hydrological models (1)
- hydroxyapatite (1)
- hydroyxapatite (1)
- hygroscopic growth (1)
- hyperoxia (1)
- iceberg discharges (1)
- immigration (1)
- impact (1)
- impacts (1)
- implicit (1)
- implicit attitude (1)
- impulsivity (1)
- in vitro blood-brain barrier model (1)
- in vitro selection (1)
- inclusion/exclusion (1)
- indigenous studies (1)
- infanticide (1)
- inference (1)
- informant discrepancies (1)
- information structure (1)
- infrastructure (1)
- innocence (1)
- innovation (1)
- inorganic mercury (1)
- inorganic nutrients (1)
- input frequency (1)
- insulin analog (1)
- insurance (1)
- inter-rater reliability (1)
- interdependences (1)
- intervention (1)
- intraclass correlation (1)
- inundation (1)
- invalidation (1)
- invasion ecology (1)
- invasive species (1)
- ionic conductivity (1)
- ionic liquids (1)
- ionogels (1)
- iron(II) (1)
- isometric eccentric force (1)
- issue market (1)
- jet (1)
- jomon skeletons (1)
- june 2013 Flood (1)
- keratinocytes (1)
- klinische Supervision (1)
- knee joint (1)
- knowledge management (1)
- kognitive Entwicklung (1)
- kognitive Verhaltenstherapie (1)
- l-cysteine desulfurase (1)
- l-edge xas (1)
- labour-market (1)
- lafora disease (1)
- laforin (1)
- lake sediments (1)
- lake-sediments (1)
- lakes (1)
- landscape (1)
- landscape controls (1)
- language (1)
- language acquisition (1)
- language changes (1)
- language contact (1)
- language-acquisition (1)
- lanthanides (1)
- large-scale assessment (1)
- last glacial period (1)
- late wintertime (1)
- late-glacial chronology (1)
- leaf economics (1)
- leaf water (1)
- legume-grass mixture (1)
- leniency bias (1)
- level rise (1)
- life events (1)
- light scattering (1)
- limiting factors (1)
- linguistic and sociolinguistic factors of language changes (1)
- liquid water (1)
- lithosphere (1)
- local hydrology (1)
- locality (1)
- localized flooding (1)
- locomotor skill (1)
- long-term (1)
- long-term policy (1)
- longevity (1)
- losses (1)
- low-intensity eco-agricultural production systems (1)
- lower critical solution temperature (1)
- lowland catchment (1)
- macroeconomic models (1)
- mai 29th (1)
- main Himalayan thrust (1)
- malin (1)
- maternal perception (1)
- mathematical model (1)
- maturational constraints (1)
- mechanical properties (1)
- mechanism (1)
- medicine (1)
- melatonin (1)
- memory pointer (1)
- mental arithmetic (1)
- mental number line (1)
- mental simulation (1)
- mercuric mercury (1)
- mesocosm experiment (1)
- mesolithic (1)
- meta-cognitive prompts (1)
- metabolic disorders (1)
- metal nanoparticles (1)
- methane oxidation (1)
- methylmercury (1)
- microsatellites (1)
- microstructure (1)
- mid-latitude Westerlies (1)
- migration (1)
- mild cognitive impairment (1)
- mineral mapping (1)
- minister responsibility (1)
- missionaries (1)
- mitigation (1)
- mitigation measures (1)
- mitochondrial control region I (1)
- mitochondrial genome (mtDNA) (1)
- mixed cropping (1)
- modality (1)
- modality compatibility (1)
- modified Alternaria toxins (1)
- moisture observing system (1)
- moisture-advection feedback (1)
- molecular thermometers (1)
- molecular-structure (1)
- molecule (1)
- molybdenum cofactor (1)
- monitoring networks (1)
- monsoon (1)
- mothers (1)
- mother–child interaction (1)
- motion of adsorbed nano-particles (1)
- motivation (1)
- motivational climate (1)
- motor control (1)
- motor equivalence (1)
- motor skill (1)
- motor skills (1)
- mowing (1)
- multi-domain nanoparticles (1)
- multi-scale habitat modeling (1)
- multicultural policy (1)
- multilevel models (1)
- multiobjective calibration (1)
- multiple scales (1)
- multitemporal (1)
- multiwavelength lidar (1)
- muscle action (1)
- muscle endurance (1)
- muscle strength (1)
- muscle strengthening (1)
- musculoskeletal (1)
- music cognition (1)
- music information retrieval (1)
- music perception (1)
- mutual information (1)
- mycotoxin profile (1)
- myocardial infarction (1)
- n-alkanes record (1)
- n-oxPTH (1)
- nanomaterials (1)
- nanoparticles (1)
- nanotoxicology (1)
- naphthalimide (1)
- narcissism (1)
- natural hazard management (1)
- near-surface snow (1)
- need for action (1)
- neo-liberal governance (1)
- neodymium (1)
- neolithic transition (1)
- net ecosystem exchange (1)
- neural networks (1)
- neural-network (1)
- neuroimaging (1)
- neuromuscular (1)
- neuronal connectivity (1)
- next generation sequencing (NGS) (1)
- next-generation sequencing (1)
- nickel(II) (1)
- nitrogen (1)
- no-till ecosystem (1)
- noise-levels (1)
- nomological network (1)
- non-athletes (1)
- nonlinear site response (1)
- norcaesalpin D (1)
- northern Baltic Sea (1)
- northern high‐latitudes (1)
- number (1)
- number processing (1)
- numerical cognition (1)
- numerical simulations (1)
- numerical-simulation (1)
- nursing homes (1)
- nutrient ratios (1)
- nutrient availability (1)
- object-based image analysis (1)
- observables (1)
- observatories (1)
- oceanic discourse (1)
- offspring (1)
- ombrotrophic peat (1)
- operational momentum (1)
- organic aerosol (1)
- organic matter (1)
- organic mercury (1)
- organic-carbon (1)
- organization (1)
- output analysis (1)
- overruns (1)
- overweight (1)
- oxazolone (1)
- oxidation (1)
- ozone concentrations (1)
- paediatric athlete (1)
- pain (1)
- palaeogenomics (1)
- paleogenomics (1)
- paracrine and autocrine regulation (1)
- parameter uncertainty (1)
- parameterization methods (1)
- parasitoid (1)
- parental quality (1)
- part 1 (1)
- partial synchronization (1)
- particle characterization (1)
- particles (1)
- party competition (1)
- passerines (1)
- pathways (1)
- pedotransfer functions (1)
- penetration enhancement (1)
- people (1)
- perception (1)
- percolation (1)
- perennial crop (1)
- performance (1)
- period (1)
- personality trait (1)
- persulfide (1)
- perturbation (1)
- ph-responsive microgels (1)
- phase (1)
- phase separation (1)
- phenology (1)
- phosphorus (1)
- photochemical oxidation (1)
- photofragmentation (1)
- photoresponsive surfactants (1)
- phylogenetic analysis (1)
- phylogeny (1)
- physical activity (1)
- physical controls (1)
- physical performance (1)
- physical properties (1)
- phytoliths (1)
- pigmentation (1)
- plant functional traits (1)
- plant strategies (1)
- plantar fascia (1)
- plants (1)
- plasticity (1)
- playa (1)
- pluvial floods (1)
- polar firn (1)
- policy analysis (1)
- political integration (1)
- poly(N-vinylcaprolactam) (1)
- polyamine (1)
- polyammonium salt (1)
- polycarboxylate (1)
- polyglucosan body (1)
- polygon (1)
- polymeric sensors (1)
- polymorohism (1)
- polyploidization (1)
- polyzwitterion (1)
- population (1)
- population dynamics (1)
- pore (1)
- positive illusionary bias (1)
- positive selection (1)
- postpartum depression (1)
- postural balance (1)
- postural stability (1)
- postural sway (1)
- potential-energy surface (1)
- pre-activity (1)
- pre-digestion (1)
- pre-participation screening (1)
- precipitation extremes (1)
- predictability (1)
- prediction (1)
- preterm birth (1)
- preterm infant (1)
- preterm infants (1)
- prevention (1)
- primary prevention (1)
- private households (1)
- privatization (1)
- proactive/reactive balance (1)
- probe (1)
- problem-solving (1)
- professional development (1)
- professions (1)
- prosody (1)
- protection (1)
- protective factors (1)
- protein (1)
- protein search (1)
- proteinuria (1)
- protonation (1)
- protozoic Si pool (1)
- proxy records (1)
- psychotherapeutic competencies (1)
- psychotherapy training (1)
- pubertal timing (1)
- puberty (1)
- public administration (1)
- qualitative content analysis (1)
- radar (1)
- radiation belts (1)
- railway transportation (1)
- rainfall gradient (1)
- rainfall-runoff response (1)
- random forest algorithm (1)
- randomized controlled trial (1)
- randomized-controlled trial (1)
- ranges (1)
- rape (1)
- rape myth acceptance (1)
- rapid-acting (1)
- rare earth elements (1)
- reaction-diffusion system (1)
- reactive oxygen species (1)
- reactive/proactive aggression (1)
- reads (1)
- recognition (1)
- recombinant protein (1)
- reconfigurable systems (1)
- reflective practice (1)
- regional patterns (1)
- register lowering (1)
- regression toward the mean (1)
- rehabilitation (1)
- relative clauses (1)
- relative dose response test (1)
- remodeling atpase brahma (1)
- remote sensing (1)
- renal disease (1)
- repeatability (1)
- representation learning (1)
- reproduction (1)
- reproductive strategies (1)
- reservior (1)
- resistance (1)
- resolution (1)
- response to treatment (1)
- responses (1)
- retinol (1)
- retinol-binding protein 4 (1)
- reveal (1)
- reveals (1)
- rice (1)
- risk (1)
- risk research (1)
- river discharge (1)
- river incision model (1)
- river-basin (1)
- robbery (1)
- rodents (1)
- runoff (1)
- runoff generation (1)
- rupture process (1)
- salt pan (1)
- salts (1)
- scale construction (1)
- scholastic demands (1)
- school (1)
- school adjustment (1)
- sea-level (1)
- sea-surface temperature (1)
- seasonal variation (1)
- seawater (1)
- sediment (1)
- seed mass (1)
- seismic tomography (1)
- seismic velocity structure (1)
- selective bond cleavage (1)
- self-assembled monolayer (1)
- self-government (1)
- self-paced reading (1)
- sensitivity-analysis (1)
- series (1)
- serum amyloid A (SAA) (1)
- sexual assault (1)
- sexual conflict (1)
- sexual selection (1)
- shared magnitude representation (1)
- short dark triad (1)
- sibilant (1)
- simulation (1)
- simulation-based attribution (1)
- single nucleotide polymorphism (1)
- single/dual tasking (1)
- site (1)
- site-condition proxies (1)
- size-congruity effect (1)
- skin (1)
- slope aspect (1)
- social pain (1)
- soil-moisture (1)
- soil-moisture dynamics (1)
- soil-nitrogen (1)
- soil-water content (1)
- solvatochromism (1)
- southeastern Spain (1)
- southern Africa (1)
- southern African plateau (1)
- space mission (1)
- space use (1)
- sparse proxy data (1)
- spatial theory (1)
- spatial turn (1)
- spatial-distribution (1)
- spatial-numerical associations (1)
- species complex (1)
- spectra (1)
- spectrum (1)
- speech (1)
- sperm storage (1)
- spherical mantle convection (1)
- sphingosine-1-phosphate (S1P) (1)
- spider silk (1)
- spin-state (1)
- stable carbon isotope (1)
- stable isotopes (1)
- stable nitrogen isotope (1)
- star excursion balance test (1)
- steady-state balance (1)
- stopover (1)
- storage changes (1)
- strategies (1)
- stream power law (1)
- streamflow (1)
- strength measurement system (1)
- stress response (1)
- stress-resistance (1)
- strong ground motion (1)
- structure beneath (1)
- student achievement (1)
- students (1)
- study demands (1)
- subsurface stormflow (1)
- sudden cardiac death (1)
- sulfurtransferase (1)
- summer (1)
- summer monsoon precipitation (1)
- summer rainfall (1)
- surface water flooding (1)
- survival (1)
- sustainable investment (1)
- swelling behavior (1)
- syntactic changes (1)
- synthetic biology (1)
- synthetic circuits (1)
- tRNA (1)
- teacher attitudes (1)
- teacher beliefs and practices (1)
- teacher knowledge (1)
- technical progress (1)
- telemedicine (1)
- telework (1)
- temperate forest (1)
- template digestion (1)
- terrain (1)
- testate amebas (1)
- thermo-responsive polymers (1)
- thinking styles (1)
- thiocarboxylate (1)
- thiomersal (1)
- thionucleosides (1)
- time averaging (1)
- time-series (1)
- token resistance (1)
- tomato (1)
- topical treatment (1)
- trace gases (1)
- training adaptation (1)
- transcription factor (1)
- transcriptional memory (1)
- transcriptional regulation (1)
- transfer (1)
- transgenerational inheritance (1)
- transnational networks (1)
- transoceanic studies (1)
- transparent orthography (1)
- transthyretin (1)
- travel (1)
- trend attribution (1)
- trend detection (1)
- trend drivers (1)
- trends (1)
- trunk (1)
- turbulence (1)
- turnover (1)
- ultra-high energy cosmic rays (1)
- ultrafast dynamics (1)
- unferring cellular networks (1)
- upper-mantle (1)
- urban politics (1)
- urban site (1)
- vadose zone (1)
- validation (1)
- validity (1)
- vapor (1)
- variables (1)
- vegetation history (1)
- vegetation patterns (1)
- vertebrates (1)
- vertical motion (1)
- veto point (1)
- vibrational structure (1)
- visual word recognition (1)
- vitamin A (1)
- vulnerability (1)
- walking (1)
- water (1)
- water content (1)
- water isotopes (1)
- water methane emissions (1)
- water-balance (1)
- water-flow (1)
- water-uptake (1)
- water-vapor (1)
- wave tomography (1)
- weather (1)
- weather extremes (1)
- weight (1)
- welfare markets (1)
- wetlands (1)
- wh- movement (1)
- wh- questions (1)
- wh-movement (1)
- wh-questions (1)
- wheat (1)
- white adipose tissue (1)
- wildflower mixture (1)
- woolly mammoth (1)
- yellow flags (1)
- Übersichtsarbeit (1)
- ‘refugee crisis’ (1)
Institute
- Mathematisch-Naturwissenschaftliche Fakultät (73)
- Humanwissenschaftliche Fakultät (36)
- Institut für Biochemie und Biologie (27)
- Institut für Geowissenschaften (20)
- Strukturbereich Kognitionswissenschaften (19)
- Institut für Physik und Astronomie (15)
- Institut für Ernährungswissenschaft (10)
- Institut für Chemie (9)
- Department Psychologie (8)
- Department Sport- und Gesundheitswissenschaften (7)
Ancient genomes have revolutionized our understanding of Holocene prehistory and, particularly, the Neolithic transition in western Eurasia. In contrast, East Asia has so far received little attention, despite representing a core region at which the Neolithic transition took place independently similar to 3 millennia after its onset in the Near East. We report genome-wide data from two hunter-gatherers from Devil's Gate, an early Neolithic cave site (dated to similar to 7.7 thousand years ago) located in East Asia, on the border between Russia and Korea. Both of these individuals are genetically most similar to geographically close modern populations from the Amur Basin, all speaking Tungusic languages, and, in particular, to the Ulchi. The similarity to nearby modern populations and the low levels of additional genetic material in the Ulchi imply a high level of genetic continuity in this region during the Holocene, a pattern that markedly contrasts with that reported for Europe.
The performance of hybridization capture combined with next-generation sequencing (NGS) has seen limited investigation with samples from hot and arid regions until now. We applied hybridization capture and shotgun sequencing to recover DNA sequences from bone specimens of ancient-domestic dromedary (Camelus dromedarius) and its extinct ancestor, the wild dromedary from Jordan, Syria, Turkey and the Arabian Peninsula, respectively. Our results show that hybridization capture increased the percentage of mitochondrial DNA (mtDNA) recovery by an average 187-fold and in some cases yielded virtually complete mitochondrial (mt) genomes at multifold coverage in a single capture experiment. Furthermore, we tested the effect of hybridization temperature and time by using a touchdown approach on a limited number of samples. We observed no significant difference in the number of unique dromedary mtDNA reads retrieved with the standard capture compared to the touchdown method. In total, we obtained 14 partial mitochondrial genomes from ancient-domestic dromedaries with 17-95% length coverage and 1.27-47.1-fold read depths for the covered regions. Using whole-genome shotgun sequencing, we successfully recovered endogenous dromedary nuclear DNA (nuDNA) from domestic and wild dromedary specimens with 1-1.06-fold read depths for covered regions. Our results highlight that despite recent methodological advances, obtaining ancient DNA (aDNA) from specimens recovered from hot, arid environments is still problematic. Hybridization protocols require specific optimization, and samples at the limit of DNA preservation need multiple replications of DNA extraction and hybridization capture as has been shown previously for Middle Pleistocene specimens.
We introduce an abstract concept of quantum field theory on categories fibered in groupoids over the category of spacetimes. This provides us with a general and flexible framework to study quantum field theories defined on spacetimes with extra geometric structures such as bundles, connections and spin structures. Using right Kan extensions, we can assign to any such theory an ordinary quantum field theory defined on the category of spacetimes and we shall clarify under which conditions it satisfies the axioms of locally covariant quantum field theory. The same constructions can be performed in a homotopy theoretic framework by using homotopy right Kan extensions, which allows us to obtain first toy-models of homotopical quantum field theories resembling some aspects of gauge theories.
Background
Cells are able to communicate and coordinate their function within tissues via secreted factors. Aberrant secretion by cancer cells can modulate this intercellular communication, in particular in highly organised tissues such as the liver. Hepatocytes, the major cell type of the liver, secrete Dickkopf (Dkk), which inhibits Wnt/ β-catenin signalling in an autocrine and paracrine manner. Consequently, Dkk modulates the expression of Wnt/ β-catenin target genes. We present a mathematical model that describes the autocrine and paracrine regulation of hepatic gene expression by Dkk under wild-type conditions as well as in the presence of mutant cells.
Results
Our spatial model describes the competition of Dkk and Wnt at receptor level, intra-cellular Wnt/ β-catenin signalling, and the regulation of target gene expression for 21 individual hepatocytes. Autocrine and paracrine regulation is mediated through a feedback mechanism via Dkk and Dkk diffusion along the porto-central axis. Along this axis an APC concentration gradient is modelled as experimentally detected in liver. Simulations of mutant cells demonstrate that already a single mutant cell increases overall Dkk concentration. The influence of the mutant cell on gene expression of surrounding wild-type hepatocytes is limited in magnitude and restricted to hepatocytes in close proximity. To explore the underlying molecular mechanisms, we perform a comprehensive analysis of the model parameters such as diffusion coefficient, mutation strength and feedback strength.
Conclusions
Our simulations show that Dkk concentration is elevated in the presence of a mutant cell. However, the impact of these elevated Dkk levels on wild-type hepatocytes is confined in space and magnitude. The combination of inter- and intracellular processes, such as Dkk feedback, diffusion and Wnt/ β-catenin signal transduction, allow wild-type hepatocytes to largely maintain their gene expression.
Background
The members of the genus Muntiacus are of particular interest to evolutionary biologists due to their extreme chromosomal rearrangements and the ongoing discussions about the number of living species. Red muntjacs have the largest distribution of all muntjacs and were formerly considered as one species. Karyotype differences led to the provisional split between the Southern Red Muntjac (Muntiacus muntjak) and the Northern Red Muntjac (M. vaginalis), but uncertainties remain as, so far, no phylogenetic study has been conducted. Here, we analysed whole mitochondrial genomes of 59 archival and 16 contemporaneous samples to resolve uncertainties about their taxonomy and used red muntjacs as model for understanding the evolutionary history of other species in Southeast Asia.
Results
We found three distinct matrilineal groups of red muntjacs: Sri Lankan red muntjacs (including the Western Ghats) diverged first from other muntjacs about 1.5 Mya; later northern red muntjacs (including North India and Indochina) and southern red muntjacs (Sundaland) split around 1.12 Mya. The diversification of red muntjacs into these three main lineages was likely promoted by two Pleistocene barriers: one through the Indian subcontinent and one separating the Indochinese and Sundaic red muntjacs. Interestingly, we found a high level of gene flow within the populations of northern and southern red muntjacs, indicating gene flow between populations in Indochina and dispersal of red muntjacs over the exposed Sunda Shelf during the Last Glacial Maximum.
Conclusions
Our results provide new insights into the evolution of species in South and Southeast Asia as we found clear genetic differentiation in a widespread and generalist species, corresponding to two known biogeographical barriers: The Isthmus of Kra and the central Indian dry zone. In addition, our molecular data support either the delineation of three monotypic species or three subspecies, but more importantly these data highlight the conservation importance of the Sri Lankan/South Indian red muntjac.
Purpose: Comparison of the dissociation kinetics of rapid-acting insulins lispro, aspart, glulisine and human insulin under physiologically relevant conditions.
Methods: Dissociation kinetics after dilution were monitored directly in terms of the average molecular mass using combined static and dynamic light scattering. Changes in tertiary structure were detected by near-UV circular dichroism.
Results: Glulisine forms compact hexamers in formulation even in the absence of Zn2+. Upon severe dilution, these rapidly dissociate into monomers in less than 10 s. In contrast, in formulations of lispro and aspart, the presence of Zn2+ and phenolic compounds is essential for formation of compact R6 hexamers. These slowly dissociate in times ranging from seconds to one hour depending on the concentration of phenolic additives. The disadvantage of the long dissociation times of lispro and aspart can be diminished by a rapid depletion of the concentration of phenolic additives independent of the insulin dilution. This is especially important in conditions similar to those after subcutaneous injection, where only minor dilution of the insulins occurs.
Conclusion: Knowledge of the diverging dissociation mechanisms of lispro and aspart compared to glulisine will be helpful for optimizing formulation conditions of rapid-acting insulins.
West German anticommunism and the SED’s Westarbeit were to some extentinterrelated. From the beginning, each German state had attemted to stabilise itsown social system while trying to discredit its political opponent. The claim tosole representation and the refusal to acknowledge each other delineated governmentalaction on both sides. Anticommunism inWest Germany re-developed under theconditions of the Cold War, which allowed it to become virtually the reason ofstate and to serve as a tool for the exclusion of KPD supporters. In its turn, theSED branded the West German State as‘revanchist’and instrumentalised itsanticommunism to persecute and eliminate opponents within the GDR. Bothphenomena had an integrative and exclusionary element.
With its transparent orthography, Standard Indonesian is spoken by over 160 million inhabitants and is the primary language of instruction in education and the government in Indonesia. An assessment battery of reading and reading-related skills was developed as a starting point for the diagnosis of dyslexia in beginner learners. Founded on the International Dyslexia Association’s definition of dyslexia, the test battery comprises nine empirically motivated reading and reading-related tasks assessing word reading, pseudoword reading, arithmetic, rapid automatized naming, phoneme deletion, forward and backward digit span, verbal fluency, orthographic choice (spelling), and writing. The test was validated by computing the relationships between the outcomes on the reading-skills and reading-related measures by means of correlation and factor analyses. External variables, i.e., school grades and teacher ratings of the reading and learning abilities of individual students, were also utilized to provide evidence of its construct validity. Four variables were found to be significantly related with reading-skill measures: phonological awareness, rapid naming, spelling, and digit span. The current study on reading development in Standard Indonesian confirms findings from other languages with transparent orthographies and suggests a test battery including preliminary norm scores for screening and assessment of elementary school children learning to read Standard Indonesian.
Theoretischer Hintergrund:Supervision spielt eine zentrale Rolle zum Wissens- und Kompetenzerwerb sowie in der Qualitätssicherung.
Fragestellung:Ziel war es, den aktuellen Forschungsstand zur Supervision im Rahmen der kognitiven Verhaltenstherapie abzubilden, um daraus Schlussfolgerungen für die zukünftige Forschung abzuleiten.
Methode:Zur Evidenzsynthese wurde ein Scoping Review durchgeführt, das die Darstellung zentraler Konzepte, aktueller Evidenz und möglicher Forschungsbedarfe ermöglichte. Neben einer systematischen Literaturrecherche wurden Vorwärts- und Rückwärtssuchstrategien eingesetzt.
Ergebnisse:Eingeschlossen wurden zwölf Publikationen basierend auf zehn empirischen Studien. Alle Studien beschrieben Ausbildungssettings, aber nur wenige untersuchten übende Interventionen (z. B. Rollenspiele). Häufig wurden Effekte subjektiv erfasst, die methodische Qualität der Begleitstudien variierte.
Schlussfolgerungen:Notwendig sind weitere methodisch hochwertige Studien, experimentell orientiert oder in der klinischen Praxis, die die Supervisionsforschung bereichern können.
Postpartale Depressionen sind häufige und schwerwiegende psychische Erkrankungen mit ungünstigem Einfluss auf die kindliche Entwicklung. Als Haupttransmissionsweg gilt die frühe Mutter-Kind-Interaktion. Über die langfristigen Auswirkungen auf die Kinder im Erwachsenenalter und die Rolle der Interaktion liegen kaum Ergebnisse vor. Im Rahmen der Mannheimer Risikokinderstudie wurden postpartale Depressionen bis zwei Jahre nach der Geburt erfasst. Die kindliche Entwicklung wurde fortlaufend und die Mutter-Kind-Interaktion im Alter von 3 Monaten standardisiert erhoben. 28 Kinder postpartal depressiver und 107 Kinder gesunder Mütter konnten mit 25 Jahren untersucht werden. Beeinträchtigungen der kognitiven und psychischen Entwicklung bei Kindern postpartal depressiver Mütter waren bis ins Erwachsenenalter nachweisbar. Responsives bzw. sensitives mütterliches Verhalten wirkte der negativen Entwicklung entgegen. Dies betont die Bedeutung einer hohen Qualität der Mutter-Kind-Interaktion für die Entwicklung von Risikokindern.
In einer prospektiven Längsschnittstudie wurden Auswirkungen früher psychosozialer Risiken bis ins junge Erwachsenenalter untersucht und dabei die Rolle von affektiver und behavioraler Dysregulation im Kindesalter als vermittelndem Faktor überprüft. Drei Monate nach der Geburt wurde das Vorliegen von 11 psychosozialen Belastungsfaktoren erfasst. Im Alter von 8 – 15 Jahren wurde dreimal das Child Behavior Checklist-Dysregulationsprofil (CBCL-DP) erhoben. Mit 25 Jahren wurde ein Strukturiertes Klinisches Interview durchgeführt und 309 der Teilnehmer füllten den Young Adult Self-Report aus. Frühe psychosoziale Risiken gingen mit einem erhöhten Risiko für das Vorliegen eines Substanzmissbrauchs im jungen Erwachsenenalter sowie mit erhöhtem externalisierendem und internalisierendem Problemverhalten einher. Der Zusammenhang zwischen frühen psychosozialen Risiken und späterem externalisierendem bzw. internalisierendem Problemverhalten wurde durch das CBCL-DP vermittelt.
Anhand von Daten der Mannheimer Risikokinderstudie, die sich mit der langfristigen Entwicklung von Kindern mit unterschiedlichen Risikobelastungen beschäftigt, wird gezeigt, wie Schutzfaktoren aufseiten des Kindes und seines familiären Umfelds im Verlauf der Entwicklung wirksam werden und zur Entstehung von Resilienz beitragen können. Eine besondere Rolle kommt dabei positiven frühen Eltern-Kind-Beziehungen zu (sowohl Mutter- als auch Vater-Kind-Interaktionen). Daneben spielen auch Interaktionserfahrungen im Alter von zwei Jahren des Kindes eine bedeutsame Rolle; diese schützen Risikokinder davor, eine ungünstige Entwicklung zu nehmen und tragen dazu bei, dass sich Kinder, die in psychosozialen Hochrisikofamilien aufwachsen, trotz ungünstiger „Startbedingungen“ positiv entwickeln. Neben Merkmalen der sozialen Umwelt nehmen auch sprachliche, sozial-emotionale und internale Kompetenzen des Kindes im Entwicklungsverlauf eine wichtige Rolle ein. Diese Kompetenzen ermöglichen es Risikokindern auch unter widrigen Lebensumständen (psychosoziale Hochrisikofamilien, Aufwachsen in Armutsverhältnissen) erfolgreich zu bestehen. Darüber hinaus zeigt die Arbeit, dass Resilienz ein Persönlichkeitsmerkmal ist, das ab dem frühen Erwachsenenalter eine hohe Stabilität besitzt. Mit diesen Befunden verweist die Arbeit auf die große Bedeutung der Resilienz bei der Vorhersage der langfristigen Entwicklung von Risikokindern.
Die langfristigen Auswirkungen von Frühgeburtlichkeit auf kognitive Entwicklung und Schulerfolg
(2017)
In einer prospektiven Längsschnittstudie wurde der Zusammenhang zwischen früher Responsivität der Mutter und kognitiver Entwicklung ihrer früh- bzw. reifgeborenen Kinder untersucht. Im Alter von drei Monaten wurde dafür die Mutter-Kind-Interaktion mittels Verhaltensbeobachtung erfasst. Bei n=351 der teilnehmenden Kinder (101 frühgeboren) wurde die allgemeine Intelligenz (IQ) im Alter von 11 Jahren und bei n=313 (85 frühgeboren) zusätzlich der höchste erreichte Schulabschluss bis 25 Jahren erhoben. Frühgeborene wiesen mit 11 Jahren einen signifikant niedrigeren IQ als Reifgeborene auf, nachdem für mögliche konfundierende Faktoren kontrolliert worden war. Nur bei Früh-, nicht aber bei Reifgeborenen zeigte sich ein signifikanter positiver Zusammenhang zwischen mütterlicher Responsivität und IQ. Für die Wahrscheinlichkeit einen höheren Schulabschluss (mind. Fachabitur) zu erreichen, fand sich weder ein signifikanter Effekt von Frühgeburtlichkeit noch von mütterlicher Responsivität.
Many studies demonstrated interactions between number processing and either spatial codes (effects of spatial-numerical associations) or visual size-related codes (size-congruity effect). However, the interrelatedness of these two number couplings is still unclear. The present study examines the simultaneous occurrence of space- and size-numerical congruency effects and their interactions both within and across trials, in a magnitude judgment task physically small or large digits were presented left or right from screen center. The reaction times analysis revealed that space- and size-congruency effects coexisted in parallel and combined additively. Moreover, a selective sequential modulation of the two congruency effects was found. The size-congruency effect was reduced after size incongruent trials. The space-congruency effect, however, was only affected by the previous space congruency. The observed independence of spatial-numerical and within magnitude associations is interpreted as evidence that the two couplings reflect Different attributes of numerical meaning possibly related to orginality and cardinality.
Mental arithmetic exhibits various biases. Among those is a tendency to overestimate addition and to underestimate subtraction outcomes. Does such “operational momentum” (OM) also affect multiplication and division? Twenty-six adults produced lines whose lengths corresponded to the correct outcomes of multiplication and division problems shown in symbolic format. We found a reliable tendency to over-estimate division outcomes, i.e., reverse OM. We suggest that anchoring on the first operand (a tendency to use this number as a reference for further quantitative reasoning) contributes to cognitive biases in mental arithmetic.
Background
Non-typhoid Salmonella Typhimurium (S. Typhimurium) accounts for a high number of registered salmonellosis cases, and O-serotyping is one important tool for monitoring epidemiology and spread of the disease. Moreover, variations in glucosylated O-antigens are related to immunogenicity and spread in the host. However, classical autoagglutination tests combined with the analysis of specific genetic markers cannot always reliably register phase variable glucose modifications expressed on Salmonella O-antigens and additional tools to monitor O-antigen glucosylation phenotypes of S. Typhimurium would be desirable.
Results
We developed a test for the phase variable O-antigen glucosylation state of S. Typhimurium using the tailspike proteins (TSP) of Salmonella phages 9NA and P22. We used this ELISA like tailspike adsorption (ELITA) assay to analyze a library of 44 Salmonella strains. ELITA was successful in discriminating strains that carried glucose 1-6 linked to the galactose of O-polysaccharide backbone (serotype O1) from non-glucosylated strains. This was shown by O-antigen compositional analyses of the respective strains with mass spectrometry and capillary electrophoresis. The ELITA test worked rapidly in a microtiter plate format and was highly O-antigen specific. Moreover, TSP as probes could also detect glucosylated strains in flow cytometry and distinguish multiphasic cultures differing in their glucosylation state.
Conclusions
Tailspike proteins contain large binding sites with precisely defined specificities and are therefore promising tools to be included in serotyping procedures as rapid serotyping agents in addition to antibodies. In this study, 9NA and P22TSP as probes could specifically distinguish glucosylation phenotypes of Salmonella on microtiter plate assays and in flow cytometry. This opens the possibility for flow sorting of cell populations for subsequent genetic analyses or for monitoring phase variations during large scale O-antigen preparations necessary for vaccine production.
Background: Although nowaday it is broadly accepted that mitochondrial DNA (mtDNA) may undergo recombination, the frequency of such recombination remains controversial. Its estimation is not straightforward, as recombination under homoplasmy (i.e., among identical mt genomes) is likely to be overlooked. In species with tandem duplications of large mtDNA fragments the detection of recombination can be facilitated, as it can lead to gene conversion among duplicates. Although the mechanisms for concerted evolution in mtDNA are not fully understood yet, recombination rates have been estimated from "one per speciation event" down to 850 years or even "during every replication cycle".
Results: Here we present the first complete mt genome of the avian family Bucerotidae, i.e., that of two Philippine hornbills, Aceros waldeni and Penelopides panini. The mt genomes are characterized by a tandemly duplicated region encompassing part of cytochrome b, 3 tRNAs, NADH6, and the control region. The duplicated fragments are identical to each other except for a short section in domain I and for the length of repeat motifs in domain III of the control region. Due to the heteroplasmy with regard to the number of these repeat motifs, there is some size variation in both genomes; with around 21,657 bp (A. waldeni) and 22,737 bp (P. panini), they significantly exceed the hitherto longest known avian mt genomes, that of the albatrosses. We discovered concerted evolution between the duplicated fragments within individuals. The existence of differences between individuals in coding genes as well as in the control region, which are maintained between duplicates, indicates that recombination apparently occurs frequently, i. e., in every generation.
Conclusions: The homogenised duplicates are interspersed by a short fragment which shows no sign of recombination. We hypothesize that this region corresponds to the so-called Replication Fork Barrier (RFB), which has been described from the chicken mitochondrial genome. As this RFB is supposed to halt replication, it offers a potential mechanistic explanation for frequent recombination in mitochondrial genomes.
Background: The Visayan Tarictic Hornbill (Penelopides panini) and the Walden's Hornbill (Aceros waldeni) are two threatened hornbill species endemic to the western islands of the Visayas that constitute - between Luzon and Mindanao - the central island group of the Philippine archipelago. In order to evaluate their genetic diversity and to support efforts towards their conservation, we analyzed genetic variation in similar to 600 base pairs (bp) of the mitochondrial control region I and at 12-19 nuclear microsatellite loci. The sampling covered extant populations, still occurring only on two islands (P. panini: Panay and Negros, A. waldeni: only Panay), and it was augmented with museum specimens of extinct populations from neighboring islands. For comparison, their less endangered (= more abundant) sister taxa, the Luzon Tarictic Hornbill (P. manillae) from the Luzon and Polillo Islands and the Writhed Hornbill (A. leucocephalus) from Mindanao Island, were also included in the study. We reconstructed the population history of the two Penelopides species and assessed the genetic population structure of the remaining wild populations in all four species.
Results: Mitochondrial and nuclear data concordantly show a clear genetic separation according to the island of origin in both Penelopides species, but also unravel sporadic over-water movements between islands. We found evidence that deforestation in the last century influenced these migratory events. Both classes of markers and the comparison to museum specimens reveal a genetic diversity loss in both Visayan hornbill species, P. panini and A. waldeni, as compared to their more abundant relatives. This might have been caused by local extinction of genetically differentiated populations together with the dramatic decline in the abundance of the extant populations.
Conclusions: We demonstrated a loss in genetic diversity of P. panini and A. waldeni as compared to their sister taxa P. manillae and A. leucocephalus. Because of the low potential for gene flow and population exchange across islands, saving of the remaining birds of almost extinct local populations - be it in the wild or in captivity - is particularly important to preserve the species' genetic potential.
The all-female Amazon molly (Poecilia formosa) is the result of a hybridization of the Atlantic molly (P. mexicana) and the sailfin molly (P. latipinna) approximately 120,000 years ago. As a gynogenetic species, P. formosa needs to copulate with heterospecific males including males from one of its bisexual ancestral species. However, the sperm only triggers embryogenesis of the diploid eggs. The genetic information of the sperm donor typically will not contribute to the next generation of P. formosa. Hence, P. formosa possesses generally one allele from each of its ancestral species at any genetic locus. This raises the question whether both ancestral alleles are equally expressed in P. formosa. Allele-specific expression (ASE) has been previously assessed in various organisms, e.g., human and fish, and ASE was found to be important in the context of phenotypic variability and disease. In this study, we utilized Real-Time PCR techniques to estimate ASE of the androgen receptor alpha (arα) gene in several distinct tissues of Amazon mollies. We found an allelic bias favoring the maternal ancestor (P. mexicana) allele in ovarian tissue. This allelic bias was not observed in the gill or the brain tissue. Sequencing of the promoter regions of both alleles revealed an association between an Indel in a known CpG island and differential expression. Future studies may reveal whether our observed cis-regulatory divergence is caused by an ovary-specific trans-regulatory element, preferentially activating the allele of the maternal ancestor.
Background
Foot orthoses are usually assumed to be effective by optimizing mechanically dynamic rearfoot configuration. However, the effect from a foot orthosis on kinematics that has been demonstrated scientifically has only been marginal. The aim of this study was to examine the effect of different heights in medial arch-supported foot orthoses on rear foot motion during gait.
Methods
Nineteen asymptomatic runners (36±11years, 180±5cm, 79±10kg; 41±22km/week) participated in the study. Trials were recorded at 3.1 mph (5 km/h) on a treadmill. Athletes walked barefoot and with 4 different not customized medial arch-supported foot orthoses of various arch heights (N:0 mm, M:30 mm, H:35 mm, E:40mm). Six infrared cameras and the `Oxford Foot Model´ were used to capture motion. The average stride in each condition was calculated from 50 gait cycles per condition. Eversion excursion and internal tibia rotation were analyzed. Descriptive statistics included calculating the mean ± SD and 95% CIs. Group differences by condition were analyzed by one factor (foot orthoses) repeated measures ANOVA (α = 0.05).
Results
Eversion excursion revealed the lowest values for N and highest for H (B:4.6°±2.2°; 95% CI [3.1;6.2]/N:4.0°±1.7°; [2.9;5.2]/M:5.2°±2.6°; [3.6;6.8]/H:6.2°±3.3°; [4.0;8.5]/E:5.1°±3.5°; [2.8;7.5]) (p>0.05). Range of internal tibia rotation was lowest with orthosis H and highest with E (B:13.3°±3.2°; 95% CI [11.0;15.6]/N:14.5°±7.2°; [9.2;19.6]/M:13.8°±5.0°; [10.8;16.8]/H:12.3°±4.3°; [9.0;15.6]/E:14.9°±5.0°; [11.5;18.3]) (p>0.05). Differences between conditions were small and the intrasubject variation high.
Conclusion
Our results indicate that different arch support heights have no systematic effect on eversion excursion or the range of internal tibia rotation and therefore might not exert a crucial influence on rear foot alignment during gait.
Plants frequently have to weather both biotic and abiotic stressors, and have evolved sophisticated adaptation and defense mechanisms. In recent years, chromatin modifications, nucleosome positioning, and DNA methylation have been recognized as important components in these adaptations. Given their potential epigenetic nature, such modifications may provide a mechanistic basis for a stress memory, enabling plants to respond more efficiently to recurring stress or even to prepare their offspring for potential future assaults. In this review, we discuss both the involvement of chromatin in stress responses and the current evidence on somatic, intergenerational, and transgenerational stress memory.
Background
Recently, the incidence rate of back pain (BP) in adolescents has been reported at 21%. However, the development of BP in adolescent athletes is unclear. Hence, the purpose of this study was to examine the incidence of BP in young elite athletes in relation to gender and type of sport practiced.
Methods
Subjective BP was assessed in 321 elite adolescent athletes (m/f 57%/43%; 13.2 ± 1.4 years; 163.4 ± 11.4 cm; 52.6 ± 12.6 kg; 5.0 ± 2.6 training yrs; 7.6 ± 5.3 training h/week). Initially, all athletes were free of pain. The main outcome criterion was the incidence of back pain [%] analyzed in terms of pain development from the first measurement day (M1) to the second measurement day (M2) after 2.0 ± 1.0 year. Participants were classified into athletes who developed back pain (BPD) and athletes who did not develop back pain (nBPD). BP (acute or within the last 7 days) was assessed with a 5-step face scale (face 1–2 = no pain; face 3–5 = pain). BPD included all athletes who reported faces 1 and 2 at M1 and faces 3 to 5 at M2. nBPD were all athletes who reported face 1 or 2 at both M1 and M2. Data was analyzed descriptively. Additionally, a Chi2 test was used to analyze gender- and sport-specific differences (p = 0.05).
Results
Thirty-two athletes were categorized as BPD (10%). The gender difference was 5% (m/f: 12%/7%) but did not show statistical significance (p = 0.15). The incidence of BP ranged between 6 and 15% for the different sport categories. Game sports (15%) showed the highest, and explosive strength sports (6%) the lowest incidence. Anthropometrics or training characteristics did not significantly influence BPD (p = 0.14 gender to p = 0.90 sports; r2 = 0.0825).
Conclusions
BP incidence was lower in adolescent athletes compared to young non-athletes and even to the general adult population. Consequently, it can be concluded that high-performance sports do not lead to an additional increase in back pain incidence during early adolescence. Nevertheless, back pain prevention programs should be implemented into daily training routines for sport categories identified as showing high incidence rates.
In the context of back pain, great emphasis has been placed on the importance of trunk stability, especially in situations requiring compensation of repetitive, intense loading induced during high-performance activities, e.g., jumping or landing. This study aims to evaluate trunk muscle activity during drop jump in adolescent athletes with back pain (BP) compared to athletes without back pain (NBP). Eleven adolescent athletes suffering back pain (BP: m/f: n = 4/7; 15.9 ± 1.3 y; 176 ± 11 cm; 68 ± 11 kg; 12.4 ± 10.5 h/we training) and 11 matched athletes without back pain (NBP: m/f: n = 4/7; 15.5 ± 1.3 y; 174 ± 7 cm; 67 ± 8 kg; 14.9 ± 9.5 h/we training) were evaluated. Subjects conducted 3 drop jumps onto a force plate (ground reaction force). Bilateral 12-lead SEMG (surface Electromyography) was applied to assess trunk muscle activity. Ground contact time [ms], maximum vertical jump force [N], jump time [ms] and the jump performance index [m/s] were calculated for drop jumps. SEMG amplitudes (RMS: root mean square [%]) for all 12 single muscles were normalized to MIVC (maximum isometric voluntary contraction) and analyzed in 4 time windows (100 ms pre- and 200 ms post-initial ground contact, 100 ms pre- and 200 ms post-landing) as outcome variables. In addition, muscles were grouped and analyzed in ventral and dorsal muscles, as well as straight and transverse trunk muscles. Drop jump ground reaction force variables did not differ between NBP and BP (p > 0.05). Mm obliquus externus and internus abdominis presented higher SEMG amplitudes (1.3–1.9-fold) for BP (p < 0.05). Mm rectus abdominis, erector spinae thoracic/lumbar and latissimus dorsi did not differ (p > 0.05). The muscle group analysis over the whole jumping cycle showed statistically significantly higher SEMG amplitudes for BP in the ventral (p = 0.031) and transverse muscles (p = 0.020) compared to NBP. Higher activity of transverse, but not straight, trunk muscles might indicate a specific compensation strategy to support trunk stability in athletes with back pain during drop jumps. Therefore, exercises favoring the transverse trunk muscles could be recommended for back pain treatment.
This study aimed to determine the relative and absolute reliability of ultrasound (US) measurements of the thickness and echogenicity of the plantar fascia (PF) at different measurement stations along its length using a standardized protocol. Twelve healthy subjects (24 feet) were enrolled. The PF was imaged in the longitudinal plane. Subjects were assessed twice to evaluate the intra-rater reliability. A quantitative evaluation of the thickness and echogenicity of the plantar fascia was performed using Image J, a digital image analysis and viewer software. A sonography evaluation of the thickness and echogenicity of the PF showed a high relative reliability with an Intra class correlation coefficient of 0.88 at all measurement stations. However, the measurement stations for both the PF thickness and echogenicity which showed the highest intraclass correlation coefficient (ICCs) did not have the highest absolute reliability. Compared to other measurement stations, measuring the PF thickness at 3 cm distal and the echogenicity at a region of interest 1 cm to 2 cm distal from its insertion at the medial calcaneal tubercle showed the highest absolute reliability with the least systematic bias and random error. Also, the reliability was higher using a mean of three measurements compared to one measurement. To reduce discrepancies in the interpretation of the thickness and echogenicity measurements of the PF, the absolute reliability of the different measurement stations should be considered in clinical practice and research rather than the relative reliability with the ICC.
Decades of research have demonstrated that physical stress (PS) stimulates bone remodeling and affects bone structure and function through complex mechanotransduction mechanisms. Recent research has laid ground to the hypothesis that mental stress (MS) also influences bone biology, eventually leading to osteoporosis and increased bone fracture risk. These effects are likely exerted by modulation of hypothalamic–pituitary–adrenal axis activity, resulting in an altered release of growth hormones, glucocorticoids and cytokines, as demonstrated in human and animal studies. Furthermore, molecular cross talk between mental and PS is thought to exist, with either synergistic or preventative effects on bone disease progression depending on the characteristics of the applied stressor. This mini review will explain the emerging concept of MS as an important player in bone adaptation and its potential cross talk with PS by summarizing the current state of knowledge, highlighting newly evolving notions (such as intergenerational transmission of stress and its epigenetic modifications affecting bone) and proposing new research directions.
Objectives: Chronic back pain (CBP) can lead to disability and burden. In addition to its medical causes, its development is influenced by psychosocial risk factors, the so-called flag factors, which are categorized and integrated into many treatment guidelines. Currently, most studies investigate single flag factors, which limit the estimation of individual factor significance in the development of chronic pain. Furthermore, factors concerning patients’ lifestyle, biography and treatment history are often neglected. Therefore, the objectives of the present study are to identify commonly neglected factors of CBP and integrate them into an analysis model comparing their significance with established flag factors.
Methods: A total of 24 patients and therapists were cross-sectionally interviewed to identify commonly neglected factors of CBP. Subsequently, the impact of these factors was surveyed in a longitudinal study. In two rehabilitation clinics, CBP patients (n = 145) were examined before and 6 months after a 3-week inpatient rehabilitation. Outcome variables, chronification factor pain experience (CF-PE) and chronification factor disability (CF-D), were ascertained with confirmatory factor analysis (CFA) of standardized questionnaires. Predictors were evaluated using stepwise calculations of simple and multiple regression models.
Results: Through interviews, medical history, iatrogenic factors, poor compliance, critical life events (LEs), social support (SS) type and effort–reward were identified as commonly neglected factors. However, only the final three held significance in comparison to established factors such as depression and pain-related cognitions. Longitudinally, lifestyle factors found to influence future pain were initial pain, physically demanding work, nicotine consumption, gender and rehabilitation clinic. LEs were unexpectedly found to be a strong predictor of future pain, as were the protective factors, reward at work and perceived SS.
Discussion: These findings shed insight regarding often overlooked factors in the development of CBP, suggesting that more detailed operationalization and superordinate frameworks would be beneficial to further research.
Conclusion: In particular, LEs should be taken into account in future research. Protective factors should be integrated in therapeutic settings.
A particular form of social pain is invalidation. Therefore, this study (a) investigates whether patients with chronic low back pain experience invalidation, (b) if it has an influence on their pain, and (c) explores whether various social sources (e.g. partner and work) influence physical pain differentially. A total of 92 patients completed questionnaires, and for analysis, Pearson's correlation coefficients and hierarchical linear regression analyses were conducted. They indicated a significant association between discounting and disability due to pain (respective =.29, p>.05). Especially, discounting by partner was linked to higher disability (=.28, p>.05).
BACKGROUND: Reduced left ventricular ejection fraction (LVEF) ≤30% is the most powerful prognostic indicator for sudden cardiac death (SCD) in patients after myocardial infarction (MI), but there are little data about long-term changes of LVEF after revascularization and the following implantation of a cardioverter defibrillator (ICD).
METHODS: We performed a retrospective analysis of 277 patients with reduced LVEF at least 1month after MI and complete revascularization. Patients (median time post-MI 23.4months; 74.3% after PCI, 25.7% after CABG were assigned either to group 1 (LVEF<30%) or group 2 (LVEF 30-40%). Biplane echocardiography was redone after a mean follow-up of 441±220days.
RESULTS: LVEF increased significantly in both two groups (group 1: 26.2±4.8% to 32.4±8.5%; p<0.001; group 2: 38.2±2.5% to 44.4±9.6%; p<0.001). However, statistical analysis of first and second LVEF measurement by means of a LOWESS regression and with an appropriate correction of the regression towards the mean effect revealed only a moderate increase of the mean LVEF from 35 to 37% (p<0.001) with a large interindividual variation.
CONCLUSIONS: The impact of early revascularization on LVEF appears to be low in the majority of post-MI heart failure patients. Owing to the high variability, a single measurement may not be reliable enough to justify a decision on ICD indication.
The Star Excursion Balance Test (SEBT) is effective in measuring dynamic postural control (DPC). This research aimed to determine whether DPC measured by the SEBT in young athletes (YA) with back pain (BP) is different from those without BP (NBP). 53 BP YA and 53 NBP YA matched for age, height, weight, training years, training sessions/week and training minutes/session were studied. Participants performed 4 practice trials after which 3 measurements in the anterior, posteromedial and posterolateral SEBT reach directions were recorded. Normalized reach distance was analyzed using the mean of all 3 measurements. There was no statistical significant difference (p > 0.05) between the reach distance of BP (87.2 ± 5.3, 82.4 ± 8.2, 78.7 ± 8.1) and NBP (87.8 ± 5.6, 82.4 ± 8.0, 80.0 ± 8.8) in the anterior, posteromedial and posterolateral directions respectively. DPC in YA with BP, as assessed by the SEBT, was not different from NBP YA.
This review analyzes the potential role and long-term effects of field perennial polycultures (mixtures) in agricultural systems, with the aim of reducing the trade-offs between provisioning and regulating ecosystem services. First, crop rotations are identified as a suitable tool for the assessment of the long-term effects of perennial polycultures on ecosystem services, which are not visible at the single-crop level. Second, the ability of perennial polycultures to support ecosystem services when used in crop rotations is quantified through eight agricultural ecosystem services. Legume-grass mixtures and wildflower mixtures are used as examples of perennial polycultures, and compared with silage maize as a typical crop for biomass production. Perennial polycultures enhance soil fertility, soil protection, climate regulation, pollination, pest and weed control, and landscape aesthetics compared with maize. They also score lower for biomass production compared with maize, which confirms the trade-off between provisioning and regulating ecosystem services. However, the additional positive factors provided by perennial polycultures, such as reduced costs for mineral fertilizer, pesticides, and soil tillage, and a significant preceding crop effect that increases the yields of subsequent crops, should be taken into account. However, a full assessment of agricultural ecosystem services requires a more holistic analysis that is beyond the capabilities of current frameworks.
Modifications of transfer RNA (tRNA) have been shown to play critical roles in the biogenesis, metabolism, structural stability and function of RNA molecules, and the specific modifications of nucleobases with sulfur atoms in tRNA are present in pro- and eukaryotes. Here, especially the thiomodifications xm(5)s(2)U at the wobble position 34 in tRNAs for Lys, Gln and Glu, were suggested to have an important role during the translation process by ensuring accurate deciphering of the genetic code and by stabilization of the tRNA structure. The trafficking and delivery of sulfur nucleosides is a complex process carried out by sulfur relay systems involving numerous proteins, which not only deliver sulfur to the specific tRNAs but also to other sulfur-containing molecules including iron-sulfur clusters, thiamin, biotin, lipoic acid and molybdopterin (MPT). Among the biosynthesis of these sulfur-containing molecules, the biosynthesis of the molybdenum cofactor (Moco) and the synthesis of thio-modified tRNAs in particular show a surprising link by sharing protein components for sulfur mobilization in pro- and eukaryotes.
Sequelae of prematurity triggered by oxidative stress and free radical-mediated tissue damage have coined the term "oxygen radical disease of prematurity". Caffeine, a potent free radical scavenger and adenosine receptor antagonist, reduces rates of brain damage in preterm infants. In the present study, we investigated the effects of caffeine on oxidative stress markers, anti-oxidative response, inflammation, redox-sensitive transcription factors, apoptosis, and extracellular matrix following the induction of hyperoxia in neonatal rats. The brain of a rat pups at postnatal Day 6 (P6) corresponds to that of a human fetal brain at 28-32 weeks gestation and the neonatal rat is an ideal model in which to investigate effects of oxidative stress and neuroprotection of caffeine on the developing brain. Six-day-old Wistar rats were pre-treated with caffeine and exposed to 80% oxygen for 24 and 48 h. Caffeine reduced oxidative stress marker (heme oxygenase-1, lipid peroxidation, hydrogen peroxide, and glutamate-cysteine ligase catalytic subunit (GCLC)), promoted anti-oxidative response (superoxide dismutase, peroxiredoxin 1, and sulfiredoxin 1), down-regulated pro-inflammatory cytokines, modulated redox-sensitive transcription factor expression (Nrf2/Keap1, and NF kappa B), reduced pro-apoptotic effectors (poly (ADP-ribose) polymerase-1 (PARP-1), apoptosis inducing factor (AIF), and caspase-3), and diminished extracellular matrix degeneration (matrix metalloproteinases (MMP) 2, and inhibitor of metalloproteinase (TIMP) 1/2). Our study affirms that caffeine is a pleiotropic neuroprotective drug in the developing brain due to its anti-oxidant, anti-inflammatory, and anti-apoptotic properties.
Molecularly imprinted polymers (MIPs) have the potential to complement antibodies in bioanalysis, are more stable under harsh conditions, and are potentially cheaper to produce. However, the affinity and especially the selectivity of MIPs are in general lower than those of their biological pendants. Enzymes are useful tools for the preparation of MIPs for both low and high-molecular weight targets: As a green alternative to the well-established methods of chemical polymerization, enzyme-initiated polymerization has been introduced and the removal of protein templates by proteases has been successfully applied. Furthermore, MIPs have been coupled with enzymes in order to enhance the analytical performance of biomimetic sensors: Enzymes have been used in MIP-sensors as tracers for the generation and amplification of the measuring signal. In addition, enzymatic pretreatment of an analyte can extend the analyte spectrum and eliminate interferences.
In assessing adolescent behavior difficulties, parents, teachers, and the adolescents themselves are key informants. However, substantial disagreement has been found between informants. Specifically, children with attention-deficit/hyperactivity disorder (ADHD) tend to overestimate their competencies, also known as “positive (illusionary) bias.” This study compared parent, teacher, and adolescent ratings of ADHD and other behavioral symptoms in a sample of 114 adolescents with ADHD. Further, the effect of cross-informant disagreement (CID) on treatment outcomes was investigated in a subsample of 54 adolescents who had undergone a training and coaching intervention. Overall, there was moderate agreement among informants. Parent and adolescent ratings were more strongly correlated with each other than with teacher ratings. The strongest discrepancy was found between teacher and adolescent ratings on prosocial behavior. This discrepancy explained 12% of the variance in parent-rated ADHD symptom severity after the intervention. The treatment was less effective in participants with high teacher-adolescent disagreement on prosocial behavior (d = 0.41) than with low disagreement (d = 0.98). These findings suggest that professionals working with adolescents with ADHD should consider multiple sources of information before initiating treatment and pay attention to cross-informant disagreements because these may indicate a risk of diminished treatment effects.
In October 2016, following a campaign led by Labour Peer Lord
Alfred Dubs, the first child asylum-seekers allowed entry to the UK
under new legislation (the ‘Dubs amendment’) arrived in England.
Their arrival was captured by a heavy media presence, and very
quickly doubts were raised by right-wing tabloids and politicians
about their age. In this article, I explore the arguments
underpinning the Dubs campaign and the media coverage of
the children’s arrival as a starting point for interrogating
representational practices around children who seek asylum. I
illustrate how the campaign was premised on a universal politics
of childhood that inadvertently laid down the terms on which
these children would be given protection, namely their innocence.
The universality of childhood fuels public sympathy for child
asylum-seekers, underlies the ‘child first, migrant second’
approach advocated by humanitarian organisations, and it was a
key argument in the ‘Dubs amendment’. Yet the campaign
highlights how representations of child asylum-seekers rely on
codes that operate to identify ‘unchildlike’ children. As I show, in
the context of the criminalisation of undocumented migrants‘,
childhood is no longer a stable category which guarantees
protection, but is subject to scrutiny and suspicion and can,
ultimately, be disproved.
Reaching the Sustainable Development Goals requires a fundamental socio-economic transformation accompanied by substantial investment in low-carbon infrastructure. Such a sustainability transition represents a non-marginal change, driven by behavioral factors and systemic interactions. However, typical economic models used to assess a sustainability transition focus on marginal changes around a local optimum, whichby constructionlead to negative effects. Thus, these models do not allow evaluating a sustainability transition that might have substantial positive effects. This paper examines which mechanisms need to be included in a standard computable general equilibrium model to overcome these limitations and to give a more comprehensive view of the effects of climate change mitigation. Simulation results show that, given an ambitious greenhouse gas emission constraint and a price of carbon, positive economic effects are possible if (1) technical progress results (partly) endogenously from the model and (2) a policy intervention triggering an increase of investment is introduced. Additionally, if (3) the investment behavior of firms is influenced by their sales expectations, the effects are amplified. The results provide suggestions for policy-makers, because the outcome indicates that investment-oriented climate policies can lead to more desirable outcomes in economic, social and environmental terms.
Background: Gestational diabetes mellitus (GDM) is associated with adverse pregnancy outcomes. It is known that GDM is associated with an altered placental function and changes in placental gene regulation. More recent studies demonstrated an involvement of epigenetic mechanisms. So far, the focus regarding placental epigenetic changes in GDM was set on gene-specific DNA methylation analyses. Studies that robustly investigated placental global DNA methylation are lacking. However, several studies showed that tissue-specific alterations in global DNA methylation are independently associated with type 2 diabetes. Thus, the aim of this study was to characterize global placental DNA methylation by robustly measuring placental DNA 5-methylcytosine (5mC) content and to examine whether differences in placental global DNA methylation are associated with GDM.
Methods: Global DNA methylation was quantified by the current gold standard method, LC-MS/MS. In total, 1030 placental samples were analyzed in this single-center birth cohort study.
Results: Mothers with GDM displayed a significantly increased global placental DNA methylation (3.22 ± 0.63 vs. 3.00 ± 0.46 %; p = 0.013; ±SD). Bivariate logistic regression showed a highly significant positive correlation between global placental DNA methylation and the presence of GDM (p = 0.0009). Quintile stratification according to placental DNA 5mC levels revealed that the frequency of GDM was evenly distributed in quintiles 1–4 (2.9–5.3 %), whereas the frequency in the fifth quintile was significantly higher (10.7 %; p = 0.003). Bivariate logistic models adjusted for maternal age, BMI, ethnicity, recurrent miscarriages, and familiar diabetes predisposition clearly demonstrated an independent association between global placental DNA hypermethylation and GDM. Furthermore, an ANCOVA model considering known predictors of DNA methylation substantiated an independent association between GDM and placental DNA methylation.
Conclusions: This is the first study that employed a robust quantitative assessment of placental global DNA methylation in over a thousand placental samples. The study provides large scale evidence that placental global DNA hypermethylation is associated with GDM, independent of established risk factors.
Theoretischer Hintergrund: Einflüsse von therapeutenorientiertem Kompetenz-Feedback in der Psychotherapieausbildung wurden bislang wenig untersucht.
Fragestellung: Wie gehen Ausbildungstherapeuten mit Feedback um? Welchen Einfluss hat ein regelmäßiges Kompetenz-Feedback auf die Qualität psychotherapeutischer Behandlungen (insbesondere Therapiesitzungen, therapeutische Beziehung, Person des Therapeuten, Supervision)?
Methode: Elf Therapeuten wurden mithilfe eines halbstrukturierten Interviewleitfadens befragt. Die Auswertung erfolgte mittels qualitativer Inhaltsanalyse nach Mayring (2015).
Ergebnisse: Das auf Basis der Interviews erstellte Kategoriensystem umfasste die Kategorien „Erwartungen an das Feedback“, „Wahrnehmung des Feedbacks“, „Verarbeitung von und Umgang mit Feedback“, „Folgen, Auswirkungen und Veränderungen durch Feedback“ sowie „Verbesserungswünsche“.
Schlussfolgerungen: Therapeuten streben eine Umsetzung des Feedbacks an, welches sich auf die Behandlung, die Supervision, die eigene Person und die therapeutische Beziehung auswirkt.
The ecological benefits of polyploidy are intensely debated. Some authors argue that plants with duplicated chromosome sets (polyploids) are more stress-resistant and superior colonizers and may thus outnumber their low ploidy conspecifics in more extreme habitats. Brachypodium distachyon (sensu lato), for example, a common annual grass in Israel and the entire Mediterranean basin, comprises three cytotypes of differing chromosome numbers that were recently proposed as distinct species. It was suggested that increased aridity increases the occurrence of its polyploid cytotype. Here, we tested at two spatial scales whether polyploid plants of B. distachyon s.l. are more frequently found in drier habitats in Israel. We collected a total of 430 specimens (i) along a largescale climatic gradient with 15 thoroughly selected sites (spanning 114–954 mm annual rainfall), and (ii) from corresponding Northern (more mesic) and Southern (more arid) hill slopes to assess the micro-climatic difference between contrasting exposures. Cytotypes were then determined via flow cytometry. Polyploid plants comprised 90% of all specimens and their proportion ranged between 0% and 100% per site. However, this proportion was not correlated with aridity along the large-scale gradient, nor were polyploids more frequently found on Southern exposures. Our results show for both spatial scales that increasing aridity is not the principal driver for the distribution of polyploids in B. distachyon s.l. in Israel. Notably, though, diploid plants were restricted essentially to four intermediate sites, while polyploids dominated the most arid and the most mesic sites. This, to some degree, clustered pattern suggests that the distribution of cytotypes is not entirely random and calls for future studies to assess further potential drivers.
VS30, slope, H800 and f0
(2017)
The aim of this paper is to investigate the ability of various site-condition proxies (SCPs) to reduce ground-motion aleatory variability and evaluate how SCPs capture nonlinearity site effects. The SCPs used here are time-averaged shear-wave velocity in the top 30 m (VS30), the topographical slope (slope), the fundamental resonance frequency (f0) and the depth beyond which Vs exceeds 800 m/s (H800). We considered first the performance of each SCP taken alone and then the combined performance of the 6 SCP pairs [VS30–f0], [VS30–H800], [f0–slope], [H800–slope], [VS30–slope] and [f0–H800]. This analysis is performed using a neural network approach including a random effect applied on a KiK-net subset for derivation of ground-motion prediction equations setting the relationship between various ground-motion parameters such as peak ground acceleration, peak ground velocity and pseudo-spectral acceleration PSA (T), and Mw, RJB, focal depth and SCPs. While the choice of SCP is found to have almost no impact on the median groundmotion prediction, it does impact the level of aleatory uncertainty. VS30 is found to perform the best of single proxies
at short periods (T < 0.6 s), while f0 and H800 perform better at longer periods; considering SCP pairs leads to significant improvements, with particular emphasis on [VS30–H800] and [f0–slope] pairs. The results also indicate significant nonlinearity on the site terms for soft sites and that the most relevant loading parameter for characterising nonlinear site response is the “stiff” spectral ordinate at the considered period.
School adjustment determines long-term adjustment in society. Yet, immigrant youth do better in some countries than in others. Drawing on acculturation research (Berry, 1997; Ward, 2001) and self-determination theory (Ryan and Deci, 2000), we investigated indirect effects of adolescent immigrants’ acculturation orientations on school adjustment (school-related attitudes, truancy, and mathematics achievement) through school belonging. Analyses were based on data from the Programme for International Student Assessment from six European countries, which were combined into three clusters based on their migrant integration and multicultural policies: Those with the most supportive policies (Belgium and Finland), those with moderately supportive policies (Italy and Portugal), and those with the most unsupportive policies (Denmark and Slovenia). In a multigroup path model, we confirmed most associations. As expected, mainstream orientation predicted higher belonging and better outcomes in all clusters, whereas the added value of students’ ethnic orientation was only observed in some clusters. Results are discussed in terms of differences in acculturative climate and policies between countries of settlement.
Schools are a major context for academic and socio-emotional development, but
also an important acculturative context. This is notably the case in adolescence,
which is a critical period for the development of a social and ethnic identity, as
well as moral reasoning and intergroup attitudes. How schools approach cultural
diversity issues is therefore likely to affect these developmental and acculturative
processes and adaptation outcomes. In the present article, the manifestation
and effects of the most prominent approaches to cultural diversity, namely
those guided by a perspective of equality and inclusion, and those guided by
a perspective of cultural pluralism, are reviewed and compared in the context
of multi-ethnic schools. The aim is to explore when and how the potential of
cultural diversity can best flourish, enhancing the academic and socio-emotional
development of culturally diverse students.
Across currents
(2017)
The purpose of the project was to develop the Discounting Inventory (DI), a measure of individual differences in delay, probability, effort, and social discounting, all related to behavioral impulsivity. Over 400 items relating to four types of discounting were generated. Next, a study followed by a series of psychometric analyses of data obtained from a group of 2843 individuals was conducted. Principal Component Analysis yielded a four-factor structure of data, reflecting the four types of discounting. The results of Confirmatory Factor Analysis showed good fit of the four-factor model to data. Through several iterations of retaining and deleting items on the basis of their component loadings, item intercorrelations, and contribution to coefficient alphas, the total number of items was reduced to 48. The final 48-item version of the inventory has satisfactory psychometric characteristics, including Cronbach’s alpha and test–retest stability. In addition, significant correlations were observed between the DI and traditional discounting instruments, suggesting that the DI measures a construct similar to the behavioral discounting process. The development of the tool was based on the assumption that discounting is a personality trait. However, the present data suggest that discounting may reflect more a state than trait function.
Cancer cachexia, of which the most notable symptom is severe and rapid weight loss, is present in the majority of patients with advanced cancer. Inflammatory mediators play an important role in the development of cachexia, envisaged as a chronic inflammatory syndrome. The white adipose tissue (WAT) is one of the first compartments affected in cancer cachexia and suffers a high rate of lipolysis. It secretes several cytokines capable of directly regulating intermediate metabolism. A common pathway in the regulation of the expression of pro-inflammatory cytokines in WAT is the activation of the nuclear transcription factor kappa-B (NF-κB). We have examined the gene expression of the subunits NF-κBp65 and NF-κBp50, as well as NF-κBp65 and NF-κBp50 binding, the gene expression of pro-inflammatory mediators under NF-κB control (IL-1β, IL-6, INF-γ, TNF-α, MCP-1), and its inhibitory protein, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IκB-α). The observational study involved 35 patients (control group, n = 12 and cancer group, n = 23, further divided into cachectic and non-cachectic). NF-κBp65 and its target genes expression (TNF-α, IL-1β, MCP-1 and IκB-α) were significantly higher in cachectic cancer patients. Moreover, NF-κBp65 gene expression correlated positively with the expression of its target genes. The results strongly suggest that the NF-κB pathway plays a role in the promotion of WAT inflammation during cachexia.
The transition from hunting and gathering to farming involved profound cultural and technological changes. In Western and Central Europe, these changes occurred rapidly and synchronously after the arrival of early farmers of Anatolian origin [1-3], who largely replaced the local Mesolithic hunter-gatherers [1, 4-6]. Further east, in the Baltic region, the transition was gradual, with little or no genetic input from incoming farmers [7]. Here we use ancient DNA to investigate the relationship between hunter-gatherers and farmers in the Lower Danube basin, a geographically intermediate area that is characterized by a rapid Neolithic transition but also by the presence of archaeological evidence that points to cultural exchange, and thus possible admixture, between hunter-gatherers and farmers. We recovered four human paleogenomes (1.13 to 4.13 coverage) from Romania spanning a time transect between 8.8 thousand years ago (kya) and 5.4 kya and supplemented them with two Mesolithic genomes (1.73- and 5.33) from Spain to provide further context on the genetic background of Mesolithic Europe. Our results show major Western hunter-gatherer (WHG) ancestry in a Romanian Eneolithic sample with a minor, but sizeable, contribution from Anatolian farmers, suggesting multiple admixture events between hunter-gatherers and farmers. Dietary stableisotope analysis of this sample suggests a mixed terrestrial/ aquatic diet. Our results provide support for complex interactions among hunter-gatherers and farmers in the Danube basin, demonstrating that in some regions, demic and cultural diffusion were not mutually exclusive, but merely the ends of a continuum for the process of Neolithization.
Palaeogenomes of Eurasian straight-tusked elephants challenge the current view of elephant evolution
(2017)
The straight-tusked elephants Palaeoloxodon spp. were widespread across Eurasia during the Pleistocene. Phylogenetic reconstructions using morphological traits have grouped them with Asian elephants (Elephas maximus), and many paleontologists place Palaeoloxodon within Elephas. Here, we report the recovery of full mitochondrial genomes from four and partial nuclear genomes from two P. antiquus fossils. These fossils were collected at two sites in Germany, Neumark-Nord and Weimar-Ehringsdorf, and likely date to interglacial periods similar to 120 and similar to 244 thousand years ago, respectively. Unexpectedly, nuclear and mitochondrial DNA analyses suggest that P. antiquus was a close relative of extant African forest elephants (Loxodonta cyclotis). Species previously referred to Palaeoloxodon are thus most parsimoniously explained as having diverged from the lineage of Loxodonta, indicating that Loxodonta has not been constrained to Africa. Our results demonstrate that the current picture of elephant evolution is in need of substantial revision.
The article explores Europeanisation as an effect of European political integration, a process driven by struggles over the legitimate political and social order that is to prevail in Europe. Firstly, an analytic framework is constructed, drawing on insights from Pierre Bourdieu’s work on similar struggles over nation-stateness. Secondly, the mechanisms identified are used to assess the role played by economic experts and expertise in the process of European political integration. It is argued that concepts arising from economic disciplines, agents educated in economics, and practising economic professionals influence European political integration and have benefited from Europeanisation initiated by this process. Special emphasis is placed on strategies of integrating Europe by law or by market, on governing Europe using economic expertise, on the role played by economic academia in researching and objectifying Europe, and on staffing European institutions with economists.
Is there an ideal time window for language acquisition after which nativelike
representation and processing are unattainable? Although this question has
been heavily debated, no consensus has been reached. Here, we present
evidence for a sensitive period in language development and show that it is
specific to grammar. We conducted a masked priming task with a group of
Turkish-German bilinguals and examined age of acquisition (AoA) effects on
the processing of complex words. We compared a subtle but meaningful
linguistic contrast, that between grammatical inflection and lexical-based
derivation. The results showed a highly selective AoA effect on inflectional
(but not derivational) priming. In addition, the effect displayed a discontinuity
indicative of a sensitive period: Priming from inflected forms was nativelike
when acquisition started before the age of 5 but declined with increasing
AoA. We conclude that the acquisition of morphological rules expressing
morphosyntactic properties is constrained by maturational factors.
Many educational technology proponents support the Technological
Pedagogical Content Knowledge (TPACK) model as a way to
conceptualize teaching with technology, but recent TPACK research
shows a need for empirical studies regarding the development of this
knowledge. This proof-of-concept study applies mixed-methods to
investigate the meta-cognitive awareness produced by teachers who
participate in the Graphic Assessment of TPACK Instrument (GATI).
This process involves creating graphical representations (circles of
differing sizes and the degree of their overlap) that represent what
teachers understand to be their current and aspired TPACK. This study
documented teachers’ explanations during a think-aloud procedure as
they created their GATI figures. The in-depth data from two German
teachers who participated in the process captured the details of their
experience and demonstrated the potential of the GATI to support
teachers in reflecting about their professional knowledge and in
determining their own professional development activities. These
findings will be informative to future pilot studies involving the larger
design of the GATI process, to better understand the role of teachers’
meta-conceptual awareness, and to better ascertain how the GATI
might be used to support professional development on a larger scale.
Between-school variation in students' achievement, motivation, affect, and learning strategies
(2017)
To plan group-randomized trials where treatment conditions are assigned to schools, researchers need design parameters that provide information about between-school differences in outcomes as well as the amount of variance that can be explained by covariates at the student (L1) and school (L2) levels. Most previous research has offered these parameters for U.S. samples and for achievement as the outcome. This paper and the online supplementary materials provide design parameters for 81 countries in three broad outcome categories (achievement, affect and motivation, and learning strategies) for domain-general and domain-specific (mathematics, reading, and science) measures. Sociodemographic characteristics were used as covariates. Data from representative samples of 15-year-old students stemmed from five cycles of the Programme for International Student Assessment (PISA; total number of students/schools: 1,905,147/70,098). Between-school differences as well as the amount of variance explained at L1 and L2 varied widely across countries and educational outcomes, demonstrating the limited generalizability of design parameters across these dimensions. The use of the design parameters to plan group-randomized trials is illustrated.
Coping, taming or solving
(2017)
One of the truisms of policy analysis is that policy problems are
rarely solved. As an ever-increasing number of policy issues are
identified as an inherently ill-structured and intractable type of
wicked problem, the question of what policy analysis sets out
to accomplish has emerged as more central than ever. If solving
wicked problems is beyond reach, research on wicked problems
needs to provide a clearer understanding of the alternatives.
The article identifies and explicates three distinguishable
strategies of problem governance: coping, taming and solving.
It shows that their intellectual premises and practical
implications clearly contrast in core respects. The article argues
that none of the identified strategies of problem governance is
invariably more suitable for dealing with wicked problems.
Rather than advocate for some universally applicable approach
to the governance of wicked problems, the article asks under
what conditions different ways of governing wicked problems
are analytically reasonable and normatively justified. It
concludes that a more systematic assessment of alternative
approaches of problem governance requires a reorientation of
the debate away from the conception of wicked problems as a
singular type toward the more focused analysis of different
dimensions of problem wickedness.
This study investigates the comprehension of wh-questions in individuals with aphasia (IWA) speaking Turkish, a non-wh-movement language, and German, a wh-movement language. We examined six German-speaking and 11 Turkish-speaking IWA using picture-pointing tasks. Findings from our experiments show that the Turkish IWA responded more accurately to both object who and object which questions than to subject questions, while the German IWA performed better for subject which questions than in all other conditions. Using random forest models, a machine learning technique used in tree-structured classification, on the individual data revealed that both the Turkish and German IWA’s response accuracy is largely predicted by the presence of overt and unambiguous case marking. We discuss our results with regard to different theoretical approaches to the comprehension of wh-questions in aphasia.
The general purpose of this systematic review was to summarize, structure and evaluate the findings on automatic evaluations of exercising. Studies were eligible for inclusion if they reported measuring automatic evaluations of exercising with an implicit measure and assessed some kind of exercise variable. Fourteen nonexperimental and six experimental studies (out of a total N = 1,928) were identified and rated by two independent reviewers. The main study characteristics were extracted and the grade of evidence for each study evaluated. First, results revealed a large heterogeneity in the applied measures to assess automatic evaluations of exercising and the exercise variables. Generally, small to large-sized significant relations between automatic evaluations of exercising and exercise variables were identified in the vast majority of studies. The review offers a systematization of the various examined exercise variables and prompts to differentiate more carefully between actually observed exercise behavior (proximal exercise indicator) and associated physiological or psychological variables (distal exercise indicator). Second, a lack of transparent reported reflections on the differing theoretical basis leading to the use of specific implicit measures was observed. Implicit measures should be applied purposefully, taking into consideration the individual advantages or disadvantages of the measures. Third, 12 studies were rated as providing first-grade evidence (lowest grade of evidence), five represent second-grade and three were rated as third-grade evidence. There is a dramatic lack of experimental studies, which are essential for illustrating the cause-effect relation between automatic evaluations of exercising and exercise and investigating under which conditions automatic evaluations of exercising influence behavior. Conclusions about the necessity of exercise interventions targeted at the alteration of automatic evaluations of exercising should therefore not be drawn too hastily.
The present study explored teachers' perspectives on one specific type of acceleration, namely, grade skipping. In addition, we investigated the extent to which teachers' beliefs about students' academic, motivational, and social development after grade skipping may explain teachers' acceptance of this accelerative strategy. Moreover, we examined whether teachers' acceptance is linked to their decisions about using this intervention. Using data from the PARS project, which included 316 teachers from 18 secondary schools in the German federal state of North Rhine-Westphalia, we assessed teachers' acceptance, beliefs, and perceived knowledge about grade skipping using 4-point rating scales. Teachers also reported whether they had advised a student to skip a grade. Multilevel regression analyses indicated that teachers' beliefs about students' social, motivational, and academic development largely explained their acceptance. Teachers who showed a higher level of acceptance and perceived knowledge were more likely to have recommended grade skipping before. Educational implications are discussed.
Plant functional traits reflect individual and community ecological strategies. They allow the detection of directional changes in community dynamics and ecosystemic processes, being an additional tool to assess biodiversity than species richness. Analysis of functional patterns in plant communities provides mechanistic insight into biodiversity alterations due to anthropogenic activity. Although studies have considered of either anthropogenic management or nutrient availability on functional traits in temperate grasslands, studies combining effects of both drivers are scarce. Here, we assessed the impacts of management intensity (fertilization, mowing, grazing), nutrient stoichiometry (C, N, P, K), and vegetation composition on community-weighted means (CWMs) and functional diversity (Rao's Q) from seven plant traits in 150 grasslands in three regions in Germany, using data of 6 years. Land use and nutrient stoichiometry accounted for larger proportions of model variance of CWM and Rao's Q than species richness and productivity. Grazing affected all analyzed trait groups; fertilization and mowing only impacted generative traits. Grazing was clearly associated with nutrient retention strategies, that is, investing in durable structures and production of fewer, less variable seed. Phenological variability was increased. Fertilization and mowing decreased seed number/mass variability, indicating competition-related effects. Impacts of nutrient stoichiometry on trait syndromes varied. Nutrient limitation (large N:P, C:N ratios) promoted species with conservative strategies, that is, investment in durable plant structures rather than fast growth, fewer seed, and delayed flowering onset. In contrast to seed mass, leaf-economics variability was reduced under P shortage. Species diversity was positively associated with the variability of generative traits. Synthesis. Here, land use, nutrient availability, species richness, and plant functional strategies have been shown to interact complexly, driving community composition, and vegetation responses to management intensity. We suggest that deeper understanding of underlying mechanisms shaping community assembly and biodiversity will require analyzing all these parameters.
The reaction of pharmacological active protic ionic liquid tris-(2-hydroxyethyl)ammonium 4-chlorophenylsulfanylacetate H + N(CH 2 CH 2 OH) 3 ∙ ( - OOCCH 2 SC 6 H 4 Cl-4) (1) with zinc or nickel chloride in a ratio of 2:1 affords stable at room temperature powder-like adducts [H + N(CH 2 CH 2 OH) 3 ] 2 ∙ [M(OOCCH 2 SC 6 H 4 Cl-4) 2 Cl 2 ] 2- , M = Zn (2), Ni (3). By recrystallization from aqueous alcohol compound 2 unexpectedly gives Zn(OOCCH 2 SC 6 H 4 Cl-4) 2 ∙ 2H 2 O (4). Unlike 2, compound 3 gives crystals [N(CH 2 CH 2 OH) 3 ] 2 Ni 2+ · [ - OOCCH 2 SC 6 H 4 Cl-4] 2 (5), which have a structure of metallated ionic liquid. The structure of 5 has been proved by X-ray diffraction analysis. It is the first example of the conversion of a protic ionic liquid into potentially biological active metallated ionic liquid (1 → 3 → 5).
Background: Functional abdominal pain (FAP) is not only a highly prevalent disease but also poses a considerable burden on children and their families. Untreated, FAP is highly persistent until adulthood, also leading to an increased risk of psychiatric disorders. Intervention studies underscore the efficacy of cognitive behavioral treatment approaches but are limited in terms of sample size, long-term follow-up data, controls and inclusion of psychosocial outcome data.
Methods/Design: In a multicenter randomized controlled trial, 112 children aged 7 to 12 years who fulfill the Rome III criteria for FAP will be allocated to an established cognitive behavioral training program for children with FAP (n = 56) or to an active control group (focusing on age-appropriate information delivery; n = 56). Randomization occurs centrally, blockwise and is stratified by center. This study is performed in five pediatric gastroenterology outpatient departments. Observer-blind assessments of outcome variables take place four times: pre-, post-, 3- and 12-months post-treatment. Primary outcome is the course of pain intensity and frequency. Secondary endpoints are health-related quality of life, pain-related coping and cognitions, as well as selfefficacy.
Discussion: This confirmatory randomized controlled clinical trial evaluates the efficacy of a cognitive behavioral intervention for children with FAP. By applying an active control group, time and attention processes can be controlled, and long-term follow-up data over the course of one year can be explored.
Background
The kidneys are essential for the metabolism of vitamin A (retinol) and its transport proteins retinol-binding protein 4 (RBP4) and transthyretin. Little is known about changes in serum concentration after living donor kidney transplantation (LDKT) as a consequence of unilateral nephrectomy; although an association of these parameters with the risk of cardiovascular diseases and insulin resistance has been suggested. Therefore we analyzed the concentration of retinol, RBP4, apoRBP4 and transthyretin in serum of 20 living-kidney donors and respective recipients at baseline as well as 6 weeks and 6 months after LDKT.
Results
As a consequence of LDKT, the kidney function of recipients was improved while the kidney function of donors was moderately reduced within 6 weeks after LDKT. With regard to vitamin A metabolism, the recipients revealed higher levels of retinol, RBP4, transthyretin and apoRBP4 before LDKT in comparison to donors. After LDKT, the levels of all four parameters decreased in serum of the recipients, while retinol, RBP4 as well as apoRBP4 serum levels of donors increased and remained increased during the follow-up period of 6 months.
Conclusion
LDKT is generally regarded as beneficial for allograft recipients and not particularly detrimental for the donors. However, it could be demonstrated in this study that a moderate reduction of kidney function by unilateral nephrectomy, resulted in an imbalance of components of vitamin A metabolism with a significant increase of retinol and RBP4 and apoRBP4 concentration in serum of donors.
Background: There is an increasing awareness of the impact of parental risk perception on the weight course of the child and the parent's readiness to engage in preventive efforts, but only less is known about factors related to the parental perception of the right time for the implementation of preventive activities. The aim of this study was to examine parental perceptions of the appropriate time to engage in child weight management strategies, and the factors associated with different weight points at which mothers recognize the need for preventive actions.
Methods: 352 mothers with children aged 2-10 years took part in the study. We assessed mothers' perceptions of the actual and preferred weight status of their child, their ability to identify overweight and knowledge of its associated health risks, as well as perceptions of the right time for action to prevent overweight in their child. A regression analysis was conducted to examine whether demographic and weight related factors as well as the maternal general risk perception were associated with recognizing the need to implement prevention strategies.
Results: Although most of the parents considered a BMI in the 75th to 90th percentile a valid reason to engage in the prevention of overweight, 19% of the mothers were not willing to engage in prevention until their child reached the 97th percentile. Whereas the child's sex and the identification of an elevated BMI were significant predictors for parents' recognition of the 75th percentile as right point to engage in prevention efforts, an inability to recognize physical health risks associated with overweight silhouettes emerged as a significant factor predicting which parents would delay prevention efforts until a child's BMI reached the 97th percentile.
Conclusion: Parental misperceptions of overweight and associated health risks constitute unfavorable conditions for preventive actions. Feedback on the health risks associated with overweight could help increase maternal readiness for change.
Background: Female sperm storage has evolved independently multiple times among vertebrates to control reproduction in response to the environment. In internally fertilising amphibians, female salamanders store sperm in cloacal spermathecae, whereas among anurans sperm storage in oviducts is known only in tailed frogs. Facilitated through extensive field sampling following historical observations we tested for sperm storing structures in the female urogenital tract of fossorial, tropical caecilian amphibians.
Findings: In the oviparous Ichthyophis cf. kohtaoensis, aggregated sperm were present in a distinct region of the posterior oviduct but not in the cloaca in six out of seven vitellogenic females prior to oviposition. Spermatozoa were found most abundantly between the mucosal folds. In relation to the reproductive status decreased amounts of sperm were present in gravid females compared to pre-ovulatory females. Sperm were absent in females past oviposition.
Conclusions: Our findings indicate short-term oviductal sperm storage in the oviparous Ichthyophis cf. kohtaoensis. We assume that in female caecilians exhibiting high levels of parental investment sperm storage has evolved in order to optimally coordinate reproductive events and to increase fitness.
Background: Obesity is not only a highly prevalent disease but also poses a considerable burden on children and their families. Evidence is increasing that a lack of self-regulation skills may play a role in the etiology and maintenance of obesity. Our goal with this currently ongoing trial is to examine whether training that focuses on the enhancement of self-regulation skills may increase the sustainability of a complex lifestyle intervention.
Methods/Design: In a multicenter, prospective, parallel group, randomized controlled superiority trial, 226 obese children and adolescents aged 8 to 16 years will be allocated either to a newly developed computer-training program to improve their self-regulation abilities or to a placebo control group. Randomization occurs centrally and blockwise at a 1:1 allocation ratio for each center. This study is performed in pediatric inpatient rehabilitation facilities specialized in the treatment of obesity. Observer-blind assessments of outcome variables take place at four times: at the beginning of the rehabilitation (pre), at the end of the training in the rehabilitation (post), and 6 and 12 months post-rehabilitation intervention. The primary outcome is the course of BMI-SDS over 1 year after the end of the inpatient rehabilitation. Secondary endpoints are the self-regulation skills. In addition, health-related quality of life, and snack intake will be analyzed.
Discussion: The computer-based training programs might be a feasible and attractive tool to increase the sustainability of the weight loss reached during inpatient rehabilitation.
The title compound, erioflorin, C19H24O6 [systematic name: (1aR,3S,4Z,5aR,8aR,9R,10aR)-1a, 2,3,5a, 7,8,8a, 9,10,10a-decahydro-3-hydroxy-4,10a-dimethyl-8-methylidene-7-oxooxireno[5,6] cyclodeca[1,2-b]furan-9-yl methacrylate], is a tricyclic germacrane sesquiterpene lactone, which was isolated from Podanthus mitiqui (L.). The compound crystallizes in the space group P2(1)2(1)2(1), and its molecular structure consists of a methacrylic ester of a ten-membered ring sesquiterpenoid annelated with an epoxide and a butyrolactone. The structure is stabilized by one intramolecular C-H center dot center dot center dot O hydrogen bond. An O-H center dot center dot center dot O hydrogen bond and further C-H center dot center dot center dot O interactions can be observed in the packing.
Background: Although the benefits for health of physical activity (PA) are well documented, the majority of the population is unable to implement present recommendations into daily routine. Mobile health (mHealth) apps could help increase the level of PA. However, this is contingent on the interest of potential users.
Objective: The aim of this study was the explorative, nuanced determination of the interest in mHealth apps with respect to PA among students and staff of a university.
Methods: We conducted a Web-based survey from June to July 2015 in which students and employees from the University of Potsdam were asked about their activity level, interest in mHealth fitness apps, chronic diseases, and sociodemographic parameters.
Results: A total of 1217 students (67.30%, 819/1217; female; 26.0 years [SD 4.9]) and 485 employees (67.5%, 327/485; female; 42.7 years [SD 11.7]) participated in the survey. The recommendation for PA (3 times per week) was not met by 70.1% (340/485) of employees and 52.67% (641/1217) of students. Within these groups, 53.2% (341/641 students) and 44.2% (150/340 employees)—independent of age, sex, body mass index (BMI), and level of education or professional qualification—indicated an interest in mHealth fitness apps.
Conclusions: Even in a younger, highly educated population, the majority of respondents reported an insufficient level of PA. About half of them indicated their interest in training support. This suggests that the use of personalized mobile fitness apps may become increasingly significant for a positive change of lifestyle.
In Vorbereitung zur Teilnahme am Times Higher Education Ranking hat die Universität Potsdam das Publikationsaufkommen im Rahmen einer Output-Analyse gemessen. Es stellte sich heraus, dass die Angabe der Affiliation, welche die Wissenschaftlerinnen und Wissenschaftler tätigen, eine wichtige Stellschraube zur Ermittlung der Grundzahl ist. Der vorliegende Artikel spiegelt die herausfordernde Ausgangssituation wider.
One of the most striking features of recent public sector reform in Europe is privatization. This development raises questions of accountability: By whom and for what are managers of private for-profit organizations delivering public goods held accountable? Analyzing accountability mechanisms through the lens of an institutional organizational approach and on the empirical basis of hospital privatization in Germany, the article contributes to the empirical and theoretical understanding of public accountability of private actors. The analysis suggests that accountability is not declining but rather multiplying. The shifts in the locus and content of accountability cause organizational stress for private hospitals.
The predictions of two contrasting approaches to the acquisition of transitive relative clauses were tested within the same groups of German-speaking participants aged from 3 to 5 years old. The input frequency approach predicts that object relative clauses with inanimate heads (e.g., the pullover that the man is scratching) are comprehended earlier and more accurately than those with an animate head (e.g., the man that the boy is scratching). In contrast, the structural intervention approach predicts that object relative clauses with two full NP arguments mismatching in number (e.g., the man that the boys are scratching) are comprehended earlier and more accurately than those with number-matching NPs (e.g., the man that the boy is scratching). These approaches were tested in two steps. First, we ran a corpus analysis to ensure that object relative clauses with number-mismatching NPs are not more frequent than object relative clauses with number-matching NPs in child directed speech. Next, the comprehension of these structures was tested experimentally in 3-, 4-, and 5-year-olds respectively by means of a color naming task. By comparing the predictions of the two approaches within the same participant groups, we were able to uncover that the effects predicted by the input frequency and by the structural intervention approaches co-exist and that they both influence the performance of children on transitive relative clauses, but in a manner that is modulated by age. These results reveal a sensitivity to animacy mismatch already being demonstrated by 3-year-olds and show that animacy is initially deployed more reliably than number to interpret relative clauses correctly. In all age groups, the animacy mismatch appears to explain the performance of children, thus, showing that the comprehension of frequent object relative clauses is enhanced compared to the other conditions. Starting with 4-year-olds but especially in 5-year-olds, the number mismatch supported comprehension—a facilitation that is unlikely to be driven by input frequency. Once children fine-tune their sensitivity to verb agreement information around the age of four, they are also able to deploy number marking to overcome the intervention effects. This study highlights the importance of testing experimentally contrasting theoretical approaches in order to characterize the multifaceted, developmental nature of language acquisition.
For various experimental applications, microbial cultures at defined, constant densities are highly advantageous over simple batch cultures. Due to high costs, however, devices for continuous culture at freely defined densities still experience limited use. We have developed a small-scale turbidostat for research purposes, which is manufactured from inexpensive components and 3D printed parts. A high degree of spatial system integration and a graphical user interface provide user-friendly operability. The used optical density feedback control allows for constant continuous culture at a wide range of densities and offers to vary culture volume and dilution rates without additional parametrization. Further, a recursive algorithm for on-line growth rate estimation has been implemented. The employed Kalman filtering approach based on a very general state model retains the flexibility of the used control type and can be easily adapted to other bioreactor designs. Within several minutes it can converge to robust, accurate growth rate estimates. This is particularly useful for directed evolution experiments or studies on metabolic challenges, as it allows direct monitoring of the population fitness.
The El Nino-Southern Oscillation (ENSO) is the main driver of the interannual variability in eastern African rainfall, with a significant impact on vegetation and agriculture and dire consequences for food and social security. In this study, we identify and quantify the ENSO contribution to the eastern African rainfall variability to forecast future eastern African vegetation response to rainfall variability related to a predicted intensified ENSO. To differentiate the vegetation variability due to ENSO, we removed the ENSO signal from the climate data using empirical orthogonal teleconnection (EOT) analysis. Then, we simulated the ecosystem carbon and water fluxes under the historical climate without components related to ENSO teleconnections. We found ENSO-driven patterns in vegetation response and confirmed that EOT analysis can successfully produce coupled tropical Pacific sea surface temperature-eastern African rainfall teleconnection from observed datasets. We further simulated eastern African vegetation response under future climate change as it is projected by climate models and under future climate change combined with a predicted increased ENSO intensity. Our EOT analysis highlights that climate simulations are still not good at capturing rainfall variability due to ENSO, and as we show here the future vegetation would be different from what is simulated under these climate model outputs lacking accurate ENSO contribution. We simulated considerable differences in eastern African vegetation growth under the influence of an intensified ENSO regime which will bring further environmental stress to a region with a reduced capacity to adapt effects of global climate change and food security.
High precipitation quantiles tend to rise with temperature, following the so-called Clausius–Clapeyron (CC) scaling. It is often reported that the CC-scaling relation breaks down and even reverts for very high temperatures. In our study, we investigate this reversal using observational climate data from 142 stations across Germany. One of the suggested meteorological explanations for the breakdown is limited moisture supply. Here we argue that, instead, it could simply originate from undersampling. As rainfall frequency generally decreases with higher temperatures, rainfall intensities as dictated by CC scaling are less likely to be recorded than for moderate temperatures. Empirical quantiles are conventionally estimated from order statistics via various forms of plotting position formulas. They have in common that their largest representable return period is given by the sample size. In small samples, high quantiles are underestimated accordingly. The small-sample effect is weaker, or disappears completely, when using parametric quantile estimates from a generalized Pareto distribution (GPD) fitted with L moments. For those, we obtain quantiles of rainfall intensities that continue to rise with temperature.
Fixational eye movements show scaling behaviour of the positional mean-squared displacement with a characteristic transition from persistence to antipersistence for increasing time-lag. These statistical patterns were found to be mainly shaped by microsaccades (fast, small-amplitude movements). However, our re-analysis of fixational eye-movement data provides evidence that the slow component (physiological drift) of the eyes exhibits scaling behaviour of the mean-squared displacement that varies across human participants. These results suggest that drift is a correlated movement that interacts with microsaccades. Moreover, on the long time scale, the mean-squared displacement of the drift shows oscillations, which is also present in the displacement auto-correlation function. This finding lends support to the presence of time-delayed feedback in the control of drift movements. Based on an earlier non-linear delayed feedback model of fixational eye movements, we propose and discuss different versions of a new model that combines a self-avoiding walk with time delay. As a result, we identify a model that reproduces oscillatory correlation functions, the transition from persistence to antipersistence, and microsaccades.
Complementarity in single photon interference – the role of the mode function and vacuum fields
(2017)
Background
In earlier experiments the role of the vacuum fields could be demonstrated as the source of complementarity with respect to the temporal properties (Heuer et al., Phys. Rev. Lett. 114:053601, 2015).
Methods
Single photon first order interferences of spatially separated regions from the cone structure of spontaneous parametric down conversion allow for analyzing the role of the mode function in quantum optics regarding the complementarity principle.
Results
Here the spatial coherence properties of these vacuum fields are demonstrated as the physical reason for complementarity in these single photon quantum optical experiments. These results are directly connected to the mode picture in classical optics.
Conclusion
The properties of the involved vacuum fields selected via the measurement process are the physical background of the complementarity principle in quantum optics.
The present study explores the perceptual span, that is, the physical extent of
the area from which useful visual information is obtained during a single
fixation, during oral reading of Chinese sentences. Characters outside a
window of legible text were replaced by visually similar characters. Results
show that the influence of window size on the perceptual span was consistent
across different fixation and oculomotor measures. To maintain normal
reading behavior when reading aloud, it was necessary to have information
provided from three characters to the right of the fixation. Together with
findings from previous research, our findings suggest that the physical size of
the perceptual span is smaller when reading aloud than in silent reading. This
is in agreement with previous studies in English, suggesting that the mechanisms
causing the reduced span in oral reading have a common base that
generalizes across languages and writing systems.
Rezensiertes Werk
Pink, Katharina, Identitas Oriens: Diskursive Konstruktionen von Identität und Alterität in britischer Orient-Reiseliteratur - Würzburg, Ergon Verlag, 2014 337 S. - (Literatur - Kultur - Theorie, 19)
Climate or land use?
(2017)
This study intends to contribute to the ongoing discussion on whether land use and land cover changes (LULC) or climate trends have the major influence on the observed increase of flood magnitudes in the Sahel. A simulation-based approach is used for attributing the observed trends to the postulated drivers. For this purpose, the ecohydrological model SWIM (Soil and Water Integrated Model) with a new, dynamic LULC module was set up for the Sahelian part of the Niger River until Niamey, including the main tributaries Sirba and Goroul. The model was driven with observed, reanalyzed climate and LULC data for the years 1950–2009. In order to quantify the shares of influence, one simulation was carried out with constant land cover as of 1950, and one including LULC. As quantitative measure, the gradients of the simulated trends were compared to the observed trend. The modeling studies showed that for the Sirba River only the simulation which included LULC was able to reproduce the observed trend. The simulation without LULC showed a positive trend for flood magnitudes, but underestimated the trend significantly. For the Goroul River and the local flood of the Niger River at Niamey, the simulations were only partly able to reproduce the observed trend. In conclusion, the new LULC module enabled some first quantitative insights into the relative influence of LULC and climatic changes. For the Sirba catchment, the results imply that LULC and climatic changes contribute in roughly equal shares to the observed increase in flooding. For the other parts of the subcatchment, the results are less clear but show, that climatic changes and LULC are drivers for the flood increase; however their shares cannot be quantified. Based on these modeling results, we argue for a two-pillar adaptation strategy to reduce current and future flood risk: Flood mitigation for reducing LULC-induced flood increase, and flood adaptation for a general reduction of flood vulnerability.
Remote sensing technology serves as a powerful tool for analyzing geospatial characteristics of flood inundation events at various scales. However, the performance of remote sensing methods depends heavily on the flood characteristics and landscape settings. Difficulties might be encountered in mapping the extent of localized flooding with shallow water on riverine floodplain areas, where patches of herbaceous vegetation are interspersed with open water surfaces. To address the difficulties in mapping inundation on areas with complex water and vegetation compositions, a high spatial resolution dataset has to be used to reduce the problem of mixed pixels. The main objective of our study was to investigate the possibilities of using a single date WorldView-2 image of very high spatial resolution and supporting data to analyze spatial patterns of localized flooding on a riverine floodplain. We used a decision tree algorithm with various combinations of input variables including spectral bands of the WorldView-2 image, selected spectral indices dedicated to mapping water surfaces and vegetation, and topographic data. The overall accuracies of the twelve flood extent maps derived with the decision tree method and performed on both pixels and image objects ranged between 77% and 95%. The highest mapping overall accuracy was achieved with a method that utilized all available input data and the object-based image analysis. Our study demonstrates the possibility of using single date WorldView-2 data for analyzing flooding events at high spatial detail despite the absence of spectral bands from the short-waveform region that are frequently used in water related studies. Our study also highlights the importance of topographic data in inundation analyses. The greatest difficulties were met in mapping water surfaces under dense canopy herbaceous vegetation, due to limited water surface exposure and the dominance of vegetation reflectance.
Motivated by conflicting evidence in the literature, we re-assessed the role of facial feedback when detecting quantitative or qualitative changes in others’ emotional expressions. Fifty-three healthy adults observed self-paced morph sequences where the emotional facial expression either changed quantitatively (i.e., sad-to-neutral, neutral-to-sad, happy-to-neutral, neutral-to-happy) or qualitatively (i.e. from sad to happy, or from happy to sad). Observers held a pen in their own mouth to induce smiling or frowning during the detection task. When morph sequences started or ended with neutral expressions we replicated a congruency effect: Happiness was perceived longer and sooner while smiling; sadness was perceived longer and sooner while frowning. Interestingly, no such congruency effects occurred for transitions between emotional expressions. These results suggest that facial feedback is especially useful when evaluating the intensity of a facial expression, but less so when we have to recognize which emotion our counterpart is expressing.
Meaning-making in the brain has become one of the most intensely discussed topics in cognitive science. Traditional theories on cognition that emphasize abstract symbol manipulations often face a dead end: The symbol grounding problem. The embodiment idea tries to overcome this barrier by assuming that the mind is grounded in sensorimotor experiences. A recent surge in behavioral and brain-imaging studies has therefore focused on the role of the motor cortex in language processing. Concrete, action-related words have received convincing evidence to rely on sensorimotor activation. Abstract concepts, however, still pose a distinct challenge for embodied theories on cognition. Fully embodied abstraction mechanisms were formulated but sensorimotor activation alone seems unlikely to close the explanatory gap. In this respect, the idea of integration areas, such as convergence zones or the ‘hub and spoke’ model, do not only appear like the most promising candidates to account for the discrepancies between concrete and abstract concepts but could also help to unite the field of cognitive science again. The current review identifies milestones in cognitive science research and recent achievements that highlight fundamental challenges, key questions and directions for future research.
Planar bis(1,2-dithiooxalato)nickelate(II), [Ni(dto)]2− reacts in aqueous solutions with lanthanide ions (Ln3+) to form pentanuclear, hetero-bimetallic complexes of the general composition [{Ln(H2O)n}2{Ni(dto)2}3]·xH2O. (n = 4 or 5; x = 9–12). The complex [{Ho(H2O)5}2{Ni(dto)2}3]·10H2O, Ho2Ni3, was synthesized and characterized by single crystal X-ray structure analysis and powder diffraction. The Ho2Ni3 complex crystallizes as monoclinic crystals in the space group P21/c. The channels and cavities, appearing in the crystal packing of the complex molecules, are occupied by a varying amount of non-coordinated water molecules.
EnGeoMAP 2.0
(2017)
Algorithms for a rapid analysis of hyperspectral data are becoming more and more important with planned next generation spaceborne hyperspectral missions such as the Environmental Mapping and Analysis Program (EnMAP) and the Japanese Hyperspectral Imager Suite (HISUI), together with an ever growing pool of hyperspectral airborne data. The here presented EnGeoMAP 2.0 algorithm is an automated system for material characterization from imaging spectroscopy data, which builds on the theoretical framework of the Tetracorder and MICA (Material Identification and Characterization Algorithm) of the United States Geological Survey and of EnGeoMAP 1.0 from 2013. EnGeoMAP 2.0 includes automated absorption feature extraction, spatio-spectral gradient calculation and mineral anomaly detection. The usage of EnGeoMAP 2.0 is demonstrated at the mineral deposit sites of Rodalquilar (SE-Spain) and Haib River (S-Namibia) using HyMAP and simulated EnMAP data. Results from Hyperion data are presented as supplementary information.
Background
Protected areas are the most common and important instrument for the conservation of biological diversity and are called for under the United Nations' Convention on Biological Diversity. Growing human population densities, intensified land-use, invasive species and increasing habitat fragmentation threaten ecosystems worldwide and protected areas are often the only refuge for endangered species. Climate change is posing an additional threat that may also impact ecosystems currently under protection. Therefore, it is of crucial importance to include the potential impact of climate change when designing future nature conservation strategies and implementing protected area management. This approach would go beyond reactive crisis management and, by necessity, would include anticipatory risk assessments. One avenue for doing so is being provided by simulation models that take advantage of the increase in computing capacity and performance that has occurred over the last two decades.
Here we review the literature to determine the state-of-the-art in modeling terrestrial protected areas under climate change, with the aim of evaluating and detecting trends and gaps in the current approaches being employed, as well as to provide a useful overview and guidelines for future research.
Results
Most studies apply statistical, bioclimatic envelope models and focus primarily on plant species as compared to other taxa. Very few studies utilize a mechanistic, process-based approach and none examine biotic interactions like predation and competition. Important factors like land-use, habitat fragmentation, invasion and dispersal are rarely incorporated, restricting the informative value of the resulting predictions considerably.
Conclusion
The general impression that emerges is that biodiversity conservation in protected areas could benefit from the application of modern modeling approaches to a greater extent than is currently reflected in the scientific literature. It is particularly true that existing models have been underutilized in testing different management options under climate change. Based on these findings we suggest a strategic framework for more effectively incorporating the impact of climate change in models exploring the effectiveness of protected areas.
The title compound was prepared by the reaction of 1,4,10,13-tetraoxa-7,16-diazacyclo-octadecane with 4-chloro-2-methyl-phenoxyacetic acid in a ratio of 1:2. The structure has been proved by the data of elemental analysis, IR spectroscopy, NMR ( 1 H, 13 C) technique and by X-ray diffraction analysis. Intermolecular hydrogen bonds between the azonium protons and oxygen atoms of the carboxylate groups were found. Immunoactive properties of the title compound have been screened. The compound has the ability to suppress spontaneous and Con A-stimulated cell proliferation in vitro and therefore can be considered as immunodepressant.
Continuous exercise (CON) and high-intensity interval exercise (HIIE) can be safely performed with type 1 diabetes mellitus (T1DM). Additionally, continuous glucose monitoring (CGM) systems may serve as a tool to reduce the risk of exercise-induced hypoglycemia. It is unclear if CGM is accurate during CON and HIIE at different mean workloads. Seven T1DM patients performed CON and HIIE at 5% below (L) and above (M) the first lactate turn point (LTP1), and 5% below the second lactate turn point (LTP2) (H) on a cycle ergometer. Glucose was measured via CGM and in capillary blood (BG). Differences were found in comparison of CGM vs. BG in three out of the six tests (p < 0.05). In CON, bias and levels of agreement for L, M, and H were found at: 0.85 (−3.44, 5.15) mmol·L−1, −0.45 (−3.95, 3.05) mmol·L−1, −0.31 (−8.83, 8.20) mmol·L−1 and at 1.17 (−2.06, 4.40) mmol·L−1, 0.11 (−5.79, 6.01) mmol·L−1, 1.48 (−2.60, 5.57) mmol·L−1 in HIIE for the same intensities. Clinically-acceptable results (except for CON H) were found. CGM estimated BG to be clinically acceptable, except for CON H. Additionally, using CGM may increase avoidance of exercise-induced hypoglycemia, but usual BG control should be performed during intense exercise.
We introduce three strategies for the analysis of financial time series based on time averaged observables. These comprise the time averaged mean squared displacement (MSD) as well as the ageing and delay time methods for varying fractions of the financial time series. We explore these concepts via statistical analysis of historic time series for several Dow Jones Industrial indices for the period from the 1960s to 2015. Remarkably, we discover a simple universal law for the delay time averaged MSD. The observed features of the financial time series dynamics agree well with our analytical results for the time averaged measurables for geometric Brownian motion, underlying the famed Black–Scholes–Merton model. The concepts we promote here are shown to be useful for financial data analysis and enable one to unveil new universal features of stock market dynamics.
Background: The biological properties of oxidized and non-oxidized PTH are substantially different. Oxidized PTH (oxPTH) loses its PTH receptor-stimulating properties, whereas non-oxidized PTH (n-oxPTH) is a full agonist of the receptor. This was described in more than 20 well published studies in the 1970(s) and 80(s). However, PTH oxidation has been ignored during the development of PTH assays for clinical use so far. Even the nowadays used third generation assay systems do not consider oxidation of PTH. We recently developed an assay to differentiate between oxPTH and n-oxPTH. In the current study we established normal values for this assay system. Furthermore, we compare the ratio of oxPTH to n-oxPTH in different population with chronic renal failure: 620 children with renal failure stage 2-4 of the 4C study, 342 adult patients on dialysis, and 602 kidney transplant recipients. In addition, we performed modeling of the interaction of either oxPTH or n-oxPTH with the PTH receptor using biophysical structure approaches. Results: The children had the highest mean as well as maximum n-oxPTH concentrations as compared to adult patients (both patients on dialysis as well as kidney transplant recipients). The relationship between oxPTH and n-oxPTH of individual patients varied substantially in all three populations with renal impairment. The analysis of n-oxPTH in 89 healthy control subjects revealed that n-oxPTH concentrations in patient with renal failure were higher as compared to healthy adult controls (2.25-fold in children with renal failure, 1.53-fold in adult patients on dialysis, and 1.56-fold in kidney transplant recipients, respectively). Computer assisted biophysical structure modeling demonstrated, however, minor sterical- and/or electrostatic changes in oxPTH and n-oxPTH. This indicated that PTH oxidation may induce refolding of PTH and hence alters PTH-PTH receptor interaction via oxidation induced three-dimensional structure alteration of PTH. Conclusion: A huge proportion of circulating PTH measured by current state-of-the-art assay systems is oxidized and thus not biologically active. The relationship between oxPTH and n-oxPTH of individual patients varied substantially. Non-oxidized PTH concentrations are 1.5 - 2.25 fold higher in patients with renal failure as compared to health controls. Measurements of n-oxPTH may reflect the hormone status more precise. The iPTH measures describes most likely oxidative stress in patients with renal failure rather than the PTH hormone status. This, however, needs to be demonstrated in further clinical studies.
In this study, an in situ application for identifying neodymium (Nd) enriched surface materials that uses multitemporal hyperspectral images is presented (HySpex sensor). Because of the narrow shape and shallow absorption depth of the neodymium absorption feature, a method was developed for enhancing and extracting the necessary information for neodymium from image spectra, even under illumination conditions that are not optimal. For this purpose, the two following approaches were developed: (1) reducing noise and analyzing changing illumination conditions by averaging multitemporal image scenes and (2) enhancing the depth of the desired absorption band by deconvolving every image spectrum with a Gaussian curve while the rest of the spectrum remains unchanged (Richardson-Lucy deconvolution). To evaluate these findings, nine field samples from the Fen complex in Norway were analyzed using handheld X-ray fluorescence devices and by conducting detailed laboratory-based geochemical rare earth element determinations. The result is a qualitative outcrop map that highlights zones that are enriched in neodymium. To reduce the influences of non-optimal illumination, particularly at the studied site, a minimum of seven single acquisitions is required. Sharpening the neodymium absorption band allows for robust mapping, even at the outer zones of enrichment. From the geochemical investigations, we found that iron oxides decrease the applicability of the method. However, iron-related absorption bands can be used as secondary indicators for sulfidic ore zones that are mainly enriched with rare earth elements. In summary, we found that hyperspectral spectroscopy is a noninvasive, fast and cost-saving method for determining neodymium at outcrop surfaces
In light of possible future restrictions on the use of fossil fuel, due to climate change obligations and continuous depletion of global fossil fuel reserves, the search for alternative renewable energy sources is expected to be an issue of great concern for policy stakeholders. This study assessed the feasibility of bioenergy production under relatively low-intensity conservative, eco-agricultural settings (as opposed to those produced under high-intensity, fossil fuel based industrialized agriculture). Estimates of the net energy gain (NEG) and the energy return on energy invested (EROEI) obtained from a life cycle inventory of the energy inputs and outputs involved reveal that the energy efficiency of bioenergy produced in low-intensity eco-agricultural systems could be as much as much as 448.5–488.3 GJ·ha−1 of NEG and an EROEI of 5.4–5.9 for maize ethanol production systems, and as much as 155.0–283.9 GJ·ha−1 of NEG and an EROEI of 14.7–22.4 for maize biogas production systems. This is substantially higher than for industrialized agriculture with a NEG of 2.8–52.5 GJ·ha−1 and an EROEI of 1.2–1.7 for maize ethanol production systems, as well as a NEG of 59.3–188.7 GJ·ha−1 and an EROEI of 2.2–10.2 for maize biogas production systems. Bioenergy produced in low-intensity eco-agricultural systems could therefore be an important source of energy with immense net benefits for local and regional end-users, provided a more efficient use of the co-products is ensured.
There is growing evidence to support change in the rehabilitation strategy of patellofemoral pain syndrome (PFPS) from traditional quadriceps strengthening exercises to inclusion of hip musculature strengthening in individuals with PFPS. Several studies have evaluated effects of quadriceps and hip musculature strengthening on PFPS with varying outcomes on pain and function. This systematic review and meta-analysis aims to synthesize outcomes of pain and function post-intervention and at follow-up to determine whether outcomes vary depending on the exercise strategy in both the short and long term. Electronic databases including MEDLINE, EMBASE, CINAHL, Web of Science, PubMed, Pedro database, Proquest, Science direct, and EBscoHost databases were searched for randomized control trials published between 1st of January 2005 and 31st of June 2015, comparing the outcomes of pain and function following quadriceps strengthening and hip musculature strengthening exercises in patients with PFPS. Two independent reviewers assessed each paper for inclusion and quality. Means and SDs were extracted from each included study to allow effect size calculations and comparison of results. Six randomized control trials met the inclusion criteria. Limited to moderate evidence indicates that hip abductor strengthening was associated with significantly lower pain post-intervention (SMD −0.88, −1.28 to −0.47 95% CI), and at 12 months (SMD −3.10, −3.71 to −2.50 95% CI) with large effect sizes (greater than 0.80) compared to quadriceps strengthening. Our findings suggest that incorporating hip musculature strengthening in management of PFPS tailored to individual ability will improve short-term and long-term outcomes of rehabilitation. Further research evaluating the effects of quadriceps and hip abductors strengthening focusing on reduction in anterior knee pain and improvement in function in management of PFPS is needed.
Spotlight on the underdogs
(2017)
Alternaria (A.) is a genus of widespread fungi capable of producing numerous, possibly health-endangering Alternaria toxins (ATs), which are usually not the focus of attention. The formation of ATs depends on the species and complex interactions of various environmental factors and is not fully understood. In this study the influence of temperature (7 °C, 25 °C), substrate (rice, wheat kernels) and incubation time (4, 7, and 14 days) on the production of thirteen ATs and three sulfoconjugated ATs by three different Alternaria isolates from the species groups A. tenuissima and A. infectoria was determined. High-performance liquid chromatography coupled with tandem mass spectrometry was used for quantification. Under nearly all conditions, tenuazonic acid was the most extensively produced toxin. At 25 °C and with increasing incubation time all toxins were formed in high amounts by the two A. tenuissima strains on both substrates with comparable mycotoxin profiles. However, for some of the toxins, stagnation or a decrease in production was observed from day 7 to 14. As opposed to the A. tenuissima strains, the A. infectoria strain only produced low amounts of ATs, but high concentrations of stemphyltoxin III. The results provide an essential insight into the quantitative in vitro AT formation under different environmental conditions, potentially transferable to different field and storage conditions
Molecules often fragment after photoionization in the gas phase. Usually, this process can only be investigated spectroscopically as long as there exists electron correlation between the photofragments. Important parameters, like their kinetic energy after separation, cannot be investigated. We are reporting on a femtosecond time-resolved Auger electron spectroscopy study concerning the photofragmentation dynamics of thymine. We observe the appearance of clearly distinguishable signatures from thymine′s neutral photofragment isocyanic acid. Furthermore, we observe a time-dependent shift of its spectrum, which we can attribute to the influence of the charged fragment on the Auger electron. This allows us to map our time-dependent dataset onto the fragmentation coordinate. The time dependence of the shift supports efficient transformation of the excess energy gained from photoionization into kinetic energy of the fragments. Our method is broadly applicable to the investigation of photofragmentation processes.
This article presents data from three production experiments investigating the prosodic means of encoding information structure in Akan, a tone language that belongs to the Kwa branch of the Niger-Congo family, spoken in Ghana. Information structure was elicited via context questions that put target words either in wide, informational, or corrective focus, or in one of the experiments also in pre-focal or post-focal position rendering it as given. The prosodic parameters F0 and duration were measured on the target words. Duration is not consistently affected by information structure, but contrary to the prediction that High (H) and Low (L) tones are raised in ex situ (fronted) focus constructions we found a significantly lower realization of both H and L tones under corrective focus in ex situ and in situ focus constructions. Givenness does not seem to be marked prosodically. The data suggest that pragmatic prominence is expressed prosodically by means of a deviation from an unmarked prosodic structure. Results are thus contradicting the view of the effort code that predicts a positive correlation of more effort resulting in higher F0 targets.
In 2009, a group of prominent Earth scientists introduced the "planetary boundaries" (PB) framework: they suggested nine global control variables, and defined corresponding "thresholds which, if crossed, could generate unacceptable environmental change". The concept builds on systems theory, and views Earth as a complex adaptive system in which anthropogenic disturbances may trigger non-linear, abrupt, and irreversible changes at the global scale, and "push the Earth system outside the stable environmental state of the Holocene". While the idea has been remarkably successful in both science and policy circles, it has also raised fundamental concerns, as the majority of suggested processes and their corresponding planetary boundaries do not operate at the global scale, and thus apparently lack the potential to trigger abrupt planetary changes.
This paper picks up the debate with specific regard to the planetary boundary on "global freshwater use". While the bio-physical impacts of excessive water consumption are typically confined to the river basin scale, the PB proponents argue that water-induced environmental disasters could build up to planetary-scale feedbacks and system failures. So far, however, no evidence has been presented to corroborate that hypothesis. Furthermore, no coherent approach has been presented to what extent a planetary threshold value could reflect the risk of regional environmental disaster. To be sure, the PB framework was revised in 2015, extending the planetary freshwater boundary with a set of basin-level boundaries inferred from environmental water flow assumptions. Yet, no new evidence was presented, either with respect to the ability of those basin-level boundaries to reflect the risk of regional regime shifts or with respect to a potential mechanism linking river basins to the planetary scale.
So while the idea of a planetary boundary on freshwater use appears intriguing, the line of arguments presented so far remains speculative and implicatory. As long as Earth system science does not present compelling evidence, the exercise of assigning actual numbers to such a boundary is arbitrary, premature, and misleading. Taken as a basis for water-related policy and management decisions, though, the idea transforms from misleading to dangerous, as it implies that we can globally offset water-related environmental impacts. A planetary boundary on freshwater use should thus be disapproved and actively refuted by the hydrological and water resources community.
Anomalous diffusion is being discovered in a fast growing number of systems. The exact nature of this anomalous diffusion provides important information on the physical laws governing the studied system. One of the central properties analysed for finite particle motion time series is the intrinsic variability of the apparent diffusivity, typically quantified by the ergodicity breaking parameter EB. Here we demonstrate that frequently EB is insufficient to provide a meaningful measure for the observed variability of the data. Instead, important additional information is provided by the higher order moments entering by the skewness and kurtosis. We analyse these quantities for three popular anomalous diffusion models. In particular, we find that even for the Gaussian fractional Brownian motion a significant skewness in the results of physical measurements occurs and needs to be taken into account. Interestingly, the kurtosis and skewness may also provide sensitive estimates of the anomalous diffusion exponent underlying the data. We also derive a new result for the EB parameter of fractional Brownian motion valid for the whole range of the anomalous diffusion parameter. Our results are important for the analysis of anomalous diffusion but also provide new insights into the theory of anomalous stochastic processes.
As an emerging sub-field of music information retrieval (MIR), music imagery information retrieval (MIIR) aims to retrieve information from brain activity recorded during music cognition–such as listening to or imagining music pieces. This is a highly inter-disciplinary endeavor that requires expertise in MIR as well as cognitive neuroscience and psychology. The OpenMIIR initiative strives to foster collaborations between these fields to advance the state of the art in MIIR. As a first step, electroencephalography (EEG) recordings of music perception and imagination have been made publicly available, enabling MIR researchers to easily test and adapt their existing approaches for music analysis like fingerprinting, beat tracking or tempo estimation on this new kind of data. This paper reports on first results of MIIR experiments using these OpenMIIR datasets and points out how these findings could drive new research in cognitive neuroscience.
Background
Back pain patients (BPP) show delayed muscle onset, increased co-contractions, and variability as response to quasi-static sudden trunk loading in comparison to healthy controls (H). However, it is unclear whether these results can validly be transferred to suddenly applied walking perturbations, an automated but more functional and complex movement pattern. There is an evident need to develop research-based strategies for the rehabilitation of back pain. Therefore, the investigation of differences in trunk stability between H and BPP in functional movements is of primary interest in order to define suitable intervention regimes. The purpose of this study was to analyse neuromuscular reflex activity as well as three-dimensional trunk kinematics between H and BPP during walking perturbations.
Methods
Eighty H (31m/49f;29±9yrs;174±10cm;71±13kg) and 14 BPP (6m/8f;30±8yrs;171±10cm;67±14kg) walked (1m/s) on a split-belt treadmill while 15 right-sided perturbations (belt decelerating, 40m/s2, 50ms duration; 200ms after heel contact) were randomly applied. Trunk muscle activity was assessed using a 12-lead EMG set-up. Trunk kinematics were measured using a 3-segment-model consisting of 12 markers (upper thoracic (UTA), lower thoracic (LTA), lumbar area (LA)). EMG-RMS ([%],0-200ms after perturbation) was calculated and normalized to the RMS of unperturbed gait. Latency (TON;ms) and time to maximum activity (TMAX;ms) were analysed. Total motion amplitude (ROM;[°]) and mean angle (Amean;[°]) for extension-flexion, lateral flexion and rotation were calculated (whole stride cycle; 0-200ms after perturbation) for each of the three segments during unperturbed and perturbed gait. For ROM only, perturbed was normalized to unperturbed step [%] for the whole stride as well as the 200ms after perturbation. Data were analysed descriptively followed by a student´s t-test to account for group differences. Co-contraction was analyzed between ventral and dorsal muscles (V:R) as well as side right:side left ratio (Sright:Sleft). The coefficient of variation (CV;%) was calculated (EMG-RMS;ROM) to evaluate variability between the 15 perturbations for all groups. With respect to unequal distribution of participants to groups, an additional matched-group analysis was conducted. Fourteen healthy controls out of group H were sex-, age- and anthropometrically matched (group Hmatched) to the BPP.
Results
No group differences were observed for EMG-RMS or CV analysis (EMG/ROM) (p>0.025). Co-contraction analysis revealed no differences for V:R and Srigth:Sleft between the groups (p>0.025). BPP showed an increased TON and TMAX, being significant for Mm. rectus abdominus (p = 0.019) and erector spinae T9/L3 (p = 0.005/p = 0.015). ROM analysis over the unperturbed stride cycle revealed no differences between groups (p>0.025). Normalization of perturbed to unperturbed step lead to significant differences for the lumbar segment (LA) in lateral flexion with BPP showing higher normalized ROM compared to Hmatched (p = 0.02). BPP showed a significant higher flexed posture (UTA (p = 0.02); LTA (p = 0.004)) during normal walking (Amean). Trunk posture (Amean) during perturbation showed higher trunk extension values in LTA segments for H/Hmatched compared to BPP (p = 0.003). Matched group (BPP vs. Hmatched) analysis did not show any systematic changes of all results between groups.
Conclusion
BPP present impaired muscle response times and trunk posture, especially in the sagittal and transversal planes, compared to H. This could indicate reduced trunk stability and higher loading during gait perturbations.
The information about climate change impact on river discharge is vitally important for planning adaptation measures. The future changes can affect different water-related sectors. The main goal of this study was to investigate the potential water resource changes in Ukraine, focusing on three mesoscale river catchments (Teteriv, UpperWestern Bug, and Samara) characteristic for different geographical zones. The catchment scale watershed model—Soil and Water Integrated Model (SWIM)—was setup, calibrated, and validated for the three catchments under consideration. A set of seven GCM-RCM (General Circulation Model-Regional Climate Model) coupled climate scenarios corresponding to RCPs (Representative Concentration Pathways) 4.5 and 8.5 were used to drive the hydrological catchment model. The climate projections, used in the study, were considered as three combinations of low, intermediate, and high end scenarios. Our results indicate the shifts in the seasonal distribution of runoff in all three catchments. The spring high flow occurs earlier as a result of temperature increases and earlier snowmelt. The fairly robust trend is an increase in river discharge in the winter season, and most of the scenarios show a potential decrease in river discharge in the spring.
Background
The hypopharyngeal gland of worker bees contributes to the production of the royal jelly fed to queens and larvae. The gland consists of thousands of two-cell units that are composed of a secretory cell and a duct cell and that are arranged in sets of about 12 around a long collecting duct.
Results
By fluorescent staining, we have examined the morphogenesis of the hypopharyngeal gland during pupal life, from a saccule lined by a pseudostratified epithelium to the elaborate organ of adult worker bees. The hypopharyngeal gland develops as follows. (1) Cell proliferation occurs during the first day of pupal life in the hypopharyngeal gland primordium. (2) Subsequently, the epithelium becomes organized into rosette-like units of three cells. Two of these will become the secretory cell and the duct cell of the adult secretory units; the third cell contributes only temporarily to the development of the secretory units and is eliminated by apoptosis in the second half of pupal life. (3) The three-cell units of flask-shaped cells undergo complex changes in cell morphology. Thus, by mid-pupal stage, the gland is structurally similar to the adult hypopharyngeal gland. (4) Concomitantly, the prospective secretory cell attains its characteristic subcellular organization by the invagination of a small patch of apical membrane domain, its extension to a tube of about 100 μm in length (termed a canaliculus), and the expansion of the tube to a diameter of about 3 μm. (6) Finally, the canaliculus-associated F-actin system becomes reorganized into rings of bundled actin filaments that are positioned at regular distances along the membrane tube.
Conclusions
The morphogenesis of the secretory units in the hypopharyngeal gland of the worker bee seems to be based on a developmental program that is conserved, with slight modification, among insects for the production of dermal glands. Elaboration of the secretory cell as a unicellular seamless epithelial tube occurs by invagination of the apical membrane, its extension likely by targeted exocytosis and its expansion, and finally the reorganisation of the membrane-associated F-actin system. Our work is fundamental for future studies of environmental effects on hypopharyngeal gland morphology and development.
This article considers Isabella Bird’s representation of medicine in Unbeaten Tracks in Japan (1880) and Journeys in Persia and Kurdistan (1891), the two books in which she engages most extensively with both local (Chinese/Islamic) and Western medical science and practice. I explore how Bird uses medicine to assert her narrative authority and define her travelling persona in opposition to local medical practitioners. I argue that her ambivalence and the unease she frequently expresses concerning medical practice (expressed particularly in her later adoption of the Persian appellation “Feringhi Hakīm” [European physician] to describe her work) serves as a means for her to negotiate the colonial and gendered pressures on Victorian medicine. While in Japan this attitude works to destabilise her hierarchical understanding of science and results in some acknowledgement of traditional Japanese traditions, in Persia it functions more to disguise her increasing collusion with overt British colonial ambitions.
Already at the beginning of the fifties on the initiative of Italy, negotiations began between the Italian and German governments for the recruitment of migrant-workers, which ended in 1955 with a bilateral agreement between the two countries. Through this recruitment policy and because of the labour-market (Industry and Building) the Italian migration was composed prevalently of men. Female immigration happened in the setting of family reunification and less as an independent movement project. After years of stagnation of italian emigration in the eighties it may also be noted that, since the early nineties, there has been a revival of immigration to Germany. This and modernisation processes in Italy changed the gender composition of the Italian immigration flow to Germany: the distance between male and female immigration is decreasing. A peculiarity of the Italians in Germany is the low occupational participation of women in comparison with other women from EU countries. However, we could observe regional differences, which depend on the migration typologies and the dominating economic structure in the areas. The paper will analyse this different aspects (immigration-processes, migrant-typologies and labour-market participation) by female Italian migrants.