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- gene flow (7)
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- interoceptive awareness (7)
- isotopes (7)
- jumping (7)
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- kinematics (7)
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- language contact (7)
- last glacial maximum (7)
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- low-energy electrons (7)
- magnetism (7)
- meaning (7)
- mechanisms (7)
- media violence (7)
- memory retrieval (7)
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- metaphor (7)
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- phase transition (7)
- phase transitions (7)
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- plasmonics (7)
- plyometric training (7)
- polyelectrolytes (7)
- porous materials (7)
- predator-prey dynamics (7)
- presidential government (7)
- preview benefit (7)
- production (7)
- programming (7)
- pronoun resolution (7)
- propensity score matching (7)
- prosodic boundary cues (7)
- proteasome (7)
- protection (7)
- pulsars: general (7)
- quality (7)
- quantification (7)
- racism (7)
- reduction (7)
- repair (7)
- retinol (7)
- rheology (7)
- roughness (7)
- scale development (7)
- screening (7)
- secular trend (7)
- sediment transport (7)
- seismic hazard (7)
- serotonin (7)
- shape-memory effect (7)
- sharing economy (7)
- silicon (7)
- size (7)
- soccer (7)
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- solar cells (7)
- solar wind (7)
- sorption (7)
- spelling (7)
- stabile Isotope (7)
- standardization (7)
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- surfactants (7)
- surveillance (7)
- tVNS (7)
- taste (7)
- techniques: image processing (7)
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- thermoresponsive polymers (7)
- time series (7)
- tomato (7)
- treeline (7)
- trunk (7)
- trust (7)
- ultrasound (7)
- uplift (7)
- urbanization (7)
- vesicles (7)
- wh-in-situ (7)
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- world literature (7)
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- Ästhetik (7)
- 3D visualization (6)
- AFM (6)
- Adhäsion (6)
- Ageing (6)
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- Fluorescence spectroscopy (6)
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- Ring current effect (6)
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- Sexual scripts (6)
- Sexual selection (6)
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- Software (6)
- Soil erosion (6)
- Solanum tuberosum (6)
- Speech perception (6)
- Sphingosine 1-phosphate (6)
- Stable isotopes (6)
- Starkregen (6)
- Sternentwicklung (6)
- Steuerung (6)
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- mind wandering (5)
- mineralization (5)
- minimum wage (5)
- mitochondrial genome (5)
- molekulare Motoren (5)
- monoclonal antibodies (5)
- morphologically complex words (5)
- mouse (5)
- multiblock copolymer (5)
- multicore architectures (5)
- multiplicative noise (5)
- musicality (5)
- narrative (5)
- natural hazard (5)
- neovascularization (5)
- neuromuscular (5)
- neutron diffraction (5)
- new public management (5)
- next-generation sequencing (5)
- non-fullerene acceptors (5)
- nonlinear (5)
- nonlinear time series analysis (5)
- norepinephrine (5)
- oncology (5)
- online (5)
- online hate (5)
- ontology (5)
- opposition (5)
- outcome (5)
- oxidation (5)
- paleomagnetism (5)
- palladium (5)
- parental mediation (5)
- partial melting (5)
- participatory research (5)
- particle-in-cell simulations (5)
- pathways (5)
- perceptual reorganization (5)
- periodization (5)
- permafrost degradation (5)
- permeability (5)
- perovskite (5)
- peroxides (5)
- phase separation (5)
- phenomenology (5)
- philosophy (5)
- phonology (5)
- photophysics (5)
- photovoltaics (5)
- physical performance (5)
- physics education (5)
- planet-star interactions (5)
- plant community (5)
- plant functional trait (5)
- plant functional traits (5)
- plateau (5)
- plyometric exercise (5)
- politeness (5)
- political education (5)
- poly(lactic acid) (5)
- polyethylene (5)
- polymer chemistry (5)
- polymer degradation (5)
- polymorphism (5)
- polypeptide (5)
- population genomics (5)
- populations (5)
- pornography (5)
- positive selection (5)
- postural sway (5)
- poverty (5)
- predictability (5)
- preferences (5)
- preferential flow (5)
- pressure (5)
- presupposition (5)
- private households (5)
- probabilistic (5)
- probiotics (5)
- problem solving (5)
- process mining (5)
- professionalization (5)
- prosocial behavior (5)
- protein modification (5)
- protein-protein interactions (5)
- psychometric properties (5)
- psychotherapy process (5)
- pupillometry (5)
- purification (5)
- qualitative analysis (5)
- quantitative Analyse (5)
- quantitative analysis (5)
- quantum field theory (5)
- race (5)
- radiocarbon (5)
- random diffusivity (5)
- random-walks (5)
- range shifts (5)
- rare earth elements (5)
- reading comprehension (5)
- real-time rendering (5)
- reconstruction (5)
- record (5)
- reflexives (5)
- regional development (5)
- rejection sensitivity (5)
- relational aggression (5)
- relativistic jets (5)
- repetition (5)
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- research projects (5)
- resonance energy transfer (5)
- resource competition (5)
- rhythmic grouping (5)
- rice (5)
- risk analysis (5)
- risk communication (5)
- risk management (5)
- risk-factors (5)
- rotifers (5)
- running (5)
- rural (5)
- salicylic acid (5)
- salt stress (5)
- savanna (5)
- scaling (5)
- scenario (5)
- scenarios (5)
- school shooting (5)
- sedimentary ancient DNA (5)
- seed bank (5)
- seismic noise (5)
- seismic tomography (5)
- seismicity (5)
- selectivity (5)
- self-employment (5)
- self-evaluation (5)
- semi-arid (5)
- semi-parliamentary government (5)
- sensitivity analysis (5)
- sentence production (5)
- sentiment analysis (5)
- service-oriented systems engineering (5)
- sex (5)
- shape-memory polymers (5)
- shotgun sequencing (5)
- silica (5)
- single-case experimental design (5)
- single-particle tracking (5)
- smart contracts (5)
- social (5)
- social acceptance (5)
- social networking sites (5)
- software development (5)
- sol-gel (5)
- spatial autocorrelation (5)
- spatial cognition (5)
- spatial-distribution (5)
- speciation (5)
- species coexistence (5)
- species distribution models (5)
- spectra (5)
- speech motor control (5)
- sphingosine-1-phosphate (5)
- sport-specific performance (5)
- sports (5)
- standards (5)
- starch phosphorylation (5)
- stars: mass loss (5)
- state (5)
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- strategy (5)
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- students (5)
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- sucrose (5)
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- tiefes Lernen (5)
- top-down control (5)
- tourism (5)
- trajectories (5)
- transcriptome (5)
- trend analysis (5)
- tunneling (5)
- tyramine (5)
- ultraviolet: ISM (5)
- uncertainties (5)
- uncertainty quantification (5)
- upconversion (5)
- urban (5)
- validation study (5)
- vegetation change (5)
- victim blame (5)
- virus (5)
- visual culture (5)
- vocational training (5)
- water resources (5)
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- weight (5)
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- words (5)
- workplace (5)
- xanthine dehydrogenase (5)
- öffentlicher Sektor (5)
- ökologische Modellierung (5)
- 1814-1831 (4)
- 2nd-language (4)
- 3D-Visualisierung (4)
- 4 (4)
- ABC transporter (4)
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- Achilles tendon (4)
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- Digitale Medien (4)
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- Eisen (4)
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- Eye-Tracking (4)
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- Flooding (4)
- Floods (4)
- Flow-Erleben (4)
- Flower buds (4)
- Fluid-rock interaction (4)
- Forecasting (4)
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- Fragmentierung (4)
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- Fredholm complexes (4)
- Friedrich Wilhelm III. (4)
- Functional diversity (4)
- Fuzzy logic (4)
- GC-MS (4)
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- Galaxy: structure (4)
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- Gaussian processes (4)
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- ISM: molecules (4)
- IT-Infrastruktur (4)
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- JUB1 (4)
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- Kyrgyzstan (4)
- LGM (4)
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- Langevin equation (4)
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- Ozon (4)
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- Phase (4)
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- Pseudo-differential operators (4)
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- Quality management (4)
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- Quantenpunkte (4)
- Quantitative Trait Locus (4)
- Quantitative Trait Locus analysis (4)
- RAFT-Polymerisation (4)
- RNAseq (4)
- Radiation belts (4)
- Random Forests (4)
- Rassendiskriminierung (4)
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- Self-esteem (4)
- Self-paced reading (4)
- Self-regulated learning (4)
- Self-regulation (4)
- Semiarid (4)
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- Simulated patients (4)
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- Transkriptom (4)
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- Triassic (4)
- Tropical forest (4)
- Tso Moriri Lake (4)
- Turkish-German bilingualism (4)
- Typ-2-Diabetes (4)
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- WA-PLS (4)
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- Weight (4)
- Weight bias internalization (4)
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- Wellenleiter (4)
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- Xanthomonas (4)
- absorption (4)
- accretion (4)
- accretion, accretion disks (4)
- accuracy (4)
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- actin (4)
- action language (4)
- action processing (4)
- action words (4)
- actuation (4)
- adaptive force (4)
- additive particles (4)
- adherence (4)
- adipogenesis (4)
- adjectives (4)
- advanced dynamic flow (4)
- aerosol (4)
- affective (4)
- agency (4)
- agent-based model (4)
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- agreement attraction (4)
- aldehyde oxidase (4)
- allelopathy (4)
- alternatives (4)
- amerikanische Reisetagebücher (4)
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- anisotropy (4)
- anorexia nervosa (4)
- antifouling (4)
- antilocality (4)
- aphids (4)
- app (4)
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- arabidopsis (4)
- arabidopsis-thaliana (4)
- argumentation (4)
- arsenolipids present (4)
- association (4)
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- attachment (4)
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- automatic evaluation (4)
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- body image (4)
- brushes (4)
- brushite (4)
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- bulimia nervosa (4)
- bulk heterojunction (4)
- business (4)
- business model (4)
- business models (4)
- calcium carbonate (4)
- capacity (4)
- carbon isotopes (4)
- carbon nitrides (4)
- cartography (4)
- catchments (4)
- categories (4)
- cell cycle (4)
- cell migration (4)
- cell wall (4)
- cellular signalling (4)
- change management (4)
- characteristics (4)
- chronic pain (4)
- circular dichroism (4)
- citizenship (4)
- civil society (4)
- climate adaptation (4)
- climate change impacts (4)
- climate extremes (4)
- clinical sample (4)
- clone (4)
- co-occurrence analysis (4)
- coating (4)
- cod-liver (4)
- coefficient (4)
- coercion (4)
- coevolution (4)
- cognitive enhancement (4)
- cognitive modeling (4)
- collaboration (4)
- collaborative consumption (4)
- collagen (4)
- colonization (4)
- color (4)
- combat sports (4)
- common vole (4)
- community structure (4)
- competencies (4)
- compliance (4)
- computer-based training (4)
- conceptualization (4)
- concrete (4)
- conduct problems (4)
- conductivity (4)
- confocal microscopy (4)
- content areas (4)
- content knowledge (4)
- content-addressable memory (4)
- context (4)
- conversational agents (4)
- conversion (4)
- convolutional neural network (4)
- copper(II) (4)
- core (4)
- corpus linguistics (4)
- cosmology (4)
- covariance (4)
- creep (4)
- critical theory (4)
- crop (4)
- crop production (4)
- cross-cultural comparison (4)
- cross-curriculum (4)
- crosslinking (4)
- crust (4)
- cultural identity (4)
- cultural pluralism (4)
- cyberbullying victimization (4)
- cyberhate (4)
- cylindrospermopsin (4)
- cystic fibrosis (4)
- cytochrome c (4)
- data mining (4)
- data preparation (4)
- data quality (4)
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- decarbonization (4)
- definition (4)
- deformation (4)
- degenerative disc disease (4)
- demography (4)
- deposition (4)
- diachrony (4)
- diagnostic competence (4)
- diagnostics (4)
- dictator game (4)
- dictyostelium (4)
- digital (4)
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- diversification (4)
- dog (4)
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- drugs (4)
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- dual-process (4)
- dyadic coping (4)
- dye (4)
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- dynamic capabilities (4)
- dynamical models (4)
- dynamical systems (4)
- e-government (4)
- eco-evolutionary experience (4)
- edge effect (4)
- effect (4)
- electron microscopy (4)
- electron paramagnetic resonance (4)
- electron-transfer (4)
- electrostatics (4)
- emissions (4)
- emotional expression (4)
- emotional intelligence (4)
- empowerment (4)
- emulsion polymerization (4)
- endophytes (4)
- endurance exercise (4)
- enhancement (4)
- entanglement (4)
- entrepreneurship education (4)
- environmental economics (4)
- environmental filtering (4)
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- errata, addenda (4)
- ethnic differences (4)
- ethnic identity (4)
- evaluative study (4)
- evaporites (4)
- event-related brain potentials (4)
- everyday life (4)
- evolutionary history (4)
- exchange (4)
- exercise intensity (4)
- expectations (4)
- experimental design (4)
- exploratory-behavior (4)
- eye-movement monitoring (4)
- face perception (4)
- family (4)
- fatty acid metabolism (4)
- fatty-acids (4)
- fault (4)
- faults (4)
- feature selection (4)
- feminism (4)
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- ferroelectrets (4)
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- ferroelectricity (4)
- financial crisis (4)
- financial institutions (4)
- finger counting (4)
- first language acquisition (4)
- first-passage (4)
- fiscal federalism (4)
- floral scent (4)
- flower development (4)
- fluctuating light (4)
- fluid inclusions (4)
- focal adhesion (4)
- food choice (4)
- food neophilia (4)
- formal verification (4)
- fractional dynamics (4)
- framework (4)
- frequency analysis (4)
- frustration (4)
- functional response (4)
- fundamental frequency (4)
- fungi (4)
- galaxies: star formation (4)
- garden-path effect (4)
- gaze-contingent displays (4)
- gene regulatory networks (4)
- genealogy (4)
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- genome-wide association (4)
- geography (4)
- geomorphometry (4)
- geothermal (4)
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- glutathione (4)
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- grammaticalization (4)
- graph theory (4)
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- graphs (4)
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- group field theory (4)
- handgrip strength (4)
- handwriting (4)
- hazard (4)
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- helical magnetic fields (4)
- hemocompatibility (4)
- heterostyly (4)
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- holding capacity (4)
- holding isometric muscle action (HIMA) (4)
- hormones (4)
- hospitals (4)
- human-computer interaction (4)
- hybrid (4)
- hybrid perovskites (4)
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- hypoxia (4)
- imitation (4)
- immune system (4)
- immunoassay (4)
- immunology (4)
- implicit attitude (4)
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- in-service teacher training (4)
- in-situ (4)
- inertial measurement unit (4)
- infinite-dimensional Brownian diffusion (4)
- infrastructure (4)
- inorganic perovskites (4)
- institutional reform (4)
- insulin signaling (4)
- interactional linguistics (4)
- interception (4)
- interface (4)
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- ionic strength (4)
- joint Simon effect (4)
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- justice (4)
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- knickpoint (4)
- knowledge sharing (4)
- komplexe Systeme (4)
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- künstliche Intelligenz (4)
- lactate (4)
- land-use intensity (4)
- language change (4)
- large-scale structure of Universe (4)
- laser pulses (4)
- left periphery (4)
- lexical access (4)
- lexicon (4)
- lichens (4)
- life satisfaction (4)
- lifetime income (4)
- light variability (4)
- line: identification (4)
- linear hypersubstitution (4)
- linear mixed models (4)
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- literacy acquisition (4)
- loading rate (4)
- local time (4)
- locomotion (4)
- locus coeruleus (4)
- locus of control (4)
- low-back-pain (4)
- lower critical solution temperature (4)
- lutein (4)
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- mammals (4)
- mass (4)
- mathematics education (4)
- mathematics instruction (4)
- meadow (4)
- measurement invariance (4)
- mechanical tendinous oscillations (4)
- media use (4)
- memory effects (4)
- mesenchymal stem cells (4)
- mesoporous materials (4)
- metabolic engineering (4)
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- metabolite (4)
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- methanogenic archaea (4)
- methyl orange (4)
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- methylmercury (4)
- micro-CT (4)
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- microlensing (4)
- micronutrients (4)
- mid-temperature transition (4)
- mild cognitive impairment (4)
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- mixtures (4)
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- molecules (4)
- moment tensor (4)
- monoclonal antibody (4)
- mood (4)
- morality (4)
- morphogenesis (4)
- motivational interviewing (4)
- mowing (4)
- multilevel analysis (4)
- multivariate statistics (4)
- muscle oxygen saturation (4)
- museum specimens (4)
- music information retrieval (4)
- n-alkanes (4)
- nachhaltige Chemie (4)
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- national identity (4)
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- nested graph conditions (4)
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- neutrinos (4)
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- next generation sequencing (NGS) (4)
- nominalization (4)
- non-alcoholic fatty liver disease (4)
- non-linear dynamics (4)
- non-native speakers (4)
- non-photorealistic rendering (4)
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- nonlinear operator (4)
- noun (4)
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- ocean acidification (4)
- ocean color remote sensing (4)
- online course creation (4)
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- optimal foraging (4)
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- osmotic-pressure (4)
- osteoblast (4)
- other-race effect (4)
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- part 1 (4)
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- physiological consequences (4)
- phytolith (4)
- picture-word interference (4)
- planetary rings (4)
- planets and satellites: atmospheres (4)
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- plasma membrane (4)
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- policy advice (4)
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- political ideology (4)
- poly(ethylene glycol) (4)
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- precursor (4)
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- proactivity (4)
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- process (4)
- properties (4)
- protein engineering (4)
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- pubertal timing (4)
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- qualitative Analyse (4)
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- radicals (4)
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- ranking (4)
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- rate of perceived exertion (4)
- rationalism (4)
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- reading motivation (4)
- receptor (4)
- recollection (4)
- recombinant inbred line (4)
- recurrence (4)
- recurrence plot (4)
- redox (4)
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- reference (4)
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- regime shift (4)
- regression (4)
- regularity (4)
- reionization (4)
- relatedness (4)
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- replication (4)
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- robustness (4)
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- root traits (4)
- rotifer (4)
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- runners (4)
- saliva (4)
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- salt (4)
- salt pan (4)
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- sequence (4)
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- shape (4)
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- sick leave (4)
- signal propagation (4)
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- sport (4)
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- victim (4)
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- 1800 (3)
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- ABCB7 (3)
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- BL Lacertae objects: individual: PKS 2155-304 (3)
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- Two forms of isometric muscle action (3)
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- air-water interface (3)
- albuminuria (3)
- allocation policies (3)
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- analytics (3)
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- arable land (3)
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- attenuation tomography (3)
- attraction (3)
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- combat sport (3)
- comets: individual: 67P/Churyumov-Gerasimenko (3)
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- contact (3)
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- continuous time random walk (3)
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- coping styles (3)
- copolymerization (3)
- coreference (3)
- coronal mass ejections (CMEs) (3)
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- corpus analysis (3)
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- correlations (3)
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- coupling (3)
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- decision tree (3)
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- deduplication (3)
- deep convection (3)
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- defense against predation (3)
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- degraded DNA (3)
- dehydration (3)
- delta-D values (3)
- democratization (3)
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- denudation (3)
- dependence (3)
- dependency (3)
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- design parameters (3)
- deutsch-jüdische Geschichte (3)
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- diffraction (3)
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- eco-evolutionary feedbacks (3)
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- ecoevolutionary dynamics (3)
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- electrophysiological evidence (3)
- elemental composition (3)
- elevated plus-maze (3)
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- elliptic complexes (3)
- embedded systems (3)
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- encoding (3)
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- endothelin-converting enzyme (3)
- endozoochory (3)
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- enjoyment (3)
- ensemble prediction (3)
- enterprise systems (3)
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- envy (3)
- enzyme immobilization (3)
- enzymology (3)
- ephrin (3)
- episodic memory (3)
- epistemic modality (3)
- equalizing and stabilizing mechanisms (3)
- equation (3)
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- erythropoiesis (3)
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- establishment (3)
- evaporation (3)
- event (3)
- eventology (3)
- evolution equation (3)
- executive personalism (3)
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- extracellular matrix (3)
- extraction and characterization methods (3)
- extremes (3)
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- eye-voice span (3)
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- facial feedback (3)
- factor analysis (3)
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- fatty acid (3)
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- fault tolerance (3)
- fermentation-related enzymes (3)
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- figurative language (3)
- filter (3)
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- fiscal equalization (3)
- fitness consequences (3)
- fixation durations (3)
- fixation locations (3)
- flavonoid (3)
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- floodplains (3)
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- fluctuation-dissipation theorem (3)
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- fracture (3)
- frameworks (3)
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- functional (3)
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- functional dependencies (3)
- functional dependency (3)
- fungal diversity (3)
- gait analysis (3)
- galaxies: fundamental parameters (3)
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- gallbladder cancer (3)
- garnet (3)
- gas adsorption (3)
- gels (3)
- gender equality (3)
- gender inequality (3)
- gene duplication (3)
- gene family (3)
- gene regulatory network (3)
- general (3)
- generalizability (3)
- generalization (3)
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- glass (3)
- global environmental change (3)
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- global surface warming (3)
- globular clusters: individual: NGC 6397 (3)
- glucan (3)
- glucocorticoid receptor (3)
- glycaemic control (3)
- glycogen (3)
- goal frames (3)
- goblet cells (3)
- good governance (3)
- grade-skipping (3)
- gradient boosting (3)
- gradient flow (3)
- grain-size distribution (3)
- grammatical illusion (3)
- granite (3)
- granitoids (3)
- graph constraints (3)
- graphite (3)
- graphomotor control (3)
- grassland (3)
- grasslands (3)
- green (3)
- green growth (3)
- green-green dilemma (3)
- gross primary production (3)
- ground reaction forces (3)
- ground-penetrating radar (3)
- grounded cognition (3)
- grouping (3)
- growth rate (3)
- guideline (3)
- guilt (3)
- habitat loss (3)
- habitus (3)
- hand (3)
- health behavior (3)
- health promotion (3)
- healthy eating (3)
- heat stress memory (3)
- heath potentials (3)
- heavy rainfall (3)
- hemispheric asymmetry (3)
- hermeneutics (3)
- heterogene Katalyse (3)
- heterogene Photokatalyse (3)
- heterogeneous photocatalysis (3)
- heterotrophic bacteria (3)
- hierarchical clustering (3)
- high temperature (3)
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- high-resolution record (3)
- high-sodium (3)
- hillslopes (3)
- hip (3)
- historiography (3)
- holography (3)
- hospital (3)
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- hostile attribution bias (3)
- housing (3)
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- hybrid model (3)
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- hydraulic fracturing (3)
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- hyperbolic tilings (3)
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- hypothesis (3)
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- ice sheet (3)
- image (3)
- image-based representation (3)
- imidazolium (3)
- immigrants (3)
- impact assessment (3)
- impedance spectroscopy (3)
- implementation (3)
- implicit association test (IAT) (3)
- implicit learning (3)
- implizit (3)
- in silico (3)
- inbreeding depression (3)
- incision (3)
- income distribution (3)
- incremental graph pattern matching (3)
- indianische Kunst (3)
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- indirect tests (3)
- individual (3)
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- individuelle Unterschiede (3)
- induced pluripotent stem cells (3)
- infant (3)
- inferences (3)
- infiltration (3)
- inflectional morphology (3)
- informatics (3)
- information integration (3)
- infrared: diffuse background (3)
- injection (3)
- inner magnetosphere (3)
- inorganic chemistry (3)
- input frequency (3)
- instrumental variables (3)
- intensification (3)
- intercultural competence (3)
- interface engineering (3)
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- interferometry (3)
- intergalaktisches Medium (3)
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- interleukin-8 (3)
- intermediate disturbance hypothesis (3)
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- internalization (3)
- international cooperation (3)
- intervention locality (3)
- intervention study (3)
- interview study (3)
- intonation units (3)
- intracellular-transport (3)
- intraclass correlation (3)
- intraspecific variation (3)
- intrinsically disordered proteins (3)
- intuition (3)
- invasion (3)
- inverse analysis (3)
- inverse micelles (3)
- inverse problem (3)
- inverse theory (3)
- ion exchange (3)
- ion transport (3)
- ionogel (3)
- ionogels (3)
- ionothermal synthesis (3)
- islands (3)
- isokinetic (3)
- isotopic composition (3)
- isotopic tiling theory (3)
- iterative regularization (3)
- job creation (3)
- job demands-resources model (3)
- job satisfaction (3)
- job search (3)
- junge Erwachsene (3)
- just transition (3)
- kana (3)
- kanji (3)
- keratinocytes (3)
- kernel density estimation (3)
- kernel methods (3)
- kettle hole (3)
- kinetic instabilities (3)
- kognitive Modellierung (3)
- kollektives Gedächtnis (3)
- kommunale Demokratie (3)
- kommunale Entscheidungsprozesse (3)
- komplexes Netzwerk (3)
- körperliche Fitness (3)
- l-cysteine desulfurase (3)
- labeling (3)
- lactate threshold (3)
- land cover change (3)
- land-use (3)
- landscape diversity (3)
- landscape homogenization (3)
- langevin equation (3)
- language attitudes (3)
- language courses (3)
- languages (3)
- large-scale (3)
- large-scale assessment (3)
- last glacial period (3)
- late Holocene (3)
- latitude (3)
- latitudinal gradient (3)
- leaf (3)
- leaf development (3)
- leaf senescence (3)
- leaking (3)
- learning and memory (3)
- learning factories (3)
- learning factory (3)
- learning styles (3)
- lebenslanges Lernen (3)
- lesson evaluation (3)
- lesson planning (3)
- lexical development (3)
- lexical tones (3)
- liberalism (3)
- life course (3)
- life-history traits (3)
- light intensity (irradiance) (3)
- limits (3)
- line: profiles (3)
- linear programming (3)
- linearized gravity (3)
- linke Peripherie (3)
- lipid (3)
- liquid-phase catalysis (3)
- literatures of the world (3)
- liver metabolism (3)
- load (3)
- local (3)
- logarithmic source condition (3)
- lokale Anpassung (3)
- long-distance dispersal (3)
- losses (3)
- lower (3)
- lower thermosphere (3)
- lupin (3)
- lysosomal storage disorders (3)
- lysosome (3)
- ländliche Entwicklung (3)
- mAb disposition (3)
- magnetic reconnection (3)
- magnetic resonance imaging (3)
- magnetoconvection (3)
- magnetotactic bacteria (3)
- magnetotaktische Bakterien (3)
- magnitude estimation (3)
- maintenance of functional diversity (3)
- major depression (3)
- majority rule (3)
- manufacturing (3)
- marine terrace (3)
- marine terraces (3)
- masculinity (3)
- mass index (3)
- mass media (3)
- mass wasting (3)
- massereiche Sterne (3)
- matching (3)
- mathematical modelling (3)
- mathematical precursor (3)
- mechanotransduction (3)
- media education (3)
- medicine (3)
- melatonin (3)
- memory and delay (3)
- mental imagery (3)
- mesocrystals (3)
- mesoporous (3)
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- metabolic disease (3)
- metagenomics (3)
- metal nanoparticles (3)
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- methane hydrate (3)
- method (3)
- methodological quality (3)
- methods: statistical (3)
- miRNAs (3)
- micro degree (3)
- micro-credential (3)
- microemulsion (3)
- microgel (3)
- micropolitics (3)
- microstructures (3)
- microwave irradiation (3)
- migrants (3)
- military culture (3)
- military history (3)
- miniemulsion (3)
- minimal pairs (3)
- minimax convergence rates (3)
- mining lakes (3)
- minorities (3)
- missing-VP effect (3)
- mitochondrial dysfunction (3)
- mitogenome (3)
- mitogenomes (3)
- mittlere Kindheit (3)
- mobile application (3)
- modal verbs (3)
- modality compatibility (3)
- model coupling (3)
- model transformation (3)
- model uncertainty (3)
- model-driven engineering (3)
- modellgetriebene Entwicklung (3)
- moderne jüdische Geschichte (3)
- modularity (3)
- molecular doping (3)
- molecular dynamics simulations (3)
- molybdenum (3)
- molybdoenzyme (3)
- monetary incentive delay task (3)
- monoklonale Antikörper (3)
- monomer (3)
- monomers (3)
- morpho-orthography (3)
- morphological decomposition (3)
- morphological priming (3)
- morphological structure (3)
- morphometrics (3)
- morphosyntax (3)
- motion capture (3)
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- motor system (3)
- movement kinematics (3)
- mu-DSC (3)
- multi-agent system (3)
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- mutation (3)
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- myth (3)
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- naphthalenes (3)
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- natal dispersal (3)
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- need satisfaction (3)
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- neural (3)
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- neutral endopeptidase (3)
- neutron (3)
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- niche and fitness differences (3)
- niche width (3)
- nichtlineare Optik (3)
- nitrogen limitation (3)
- noisy systems (3)
- non-Langevin recombination (3)
- non-athletes (3)
- non-categoricity (3)
- nonfullerene acceptors (3)
- nonlinear optics (3)
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- octopamine (3)
- offspring (3)
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- older patients (3)
- olivine (3)
- omega-3 fatty acids (3)
- on-water performance (3)
- one-carbon metabolism (3)
- online course (3)
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- origin (3)
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- outlier detection (3)
- output analysis (3)
- overweight children (3)
- oxygen isotopes (3)
- oxygen reduction reaction (3)
- ozone (3)
- palaeolimnology (3)
- paleo-sediment (3)
- paleogenetics (3)
- paleovegetation (3)
- paper (3)
- parafoveal (3)
- parafoveal-on-foveal effect (3)
- parallel processing (3)
- parameterization (3)
- parasitoid (3)
- parchment (3)
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- parliamentary opposition (3)
- particles (3)
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- pea (3)
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- peatlands (3)
- pedagogical content knowledge (3)
- peer influences (3)
- peers (3)
- perceived stress (3)
- perception and action (3)
- performance information use (3)
- periphyton (3)
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- personality traits (3)
- perspective taking (3)
- phagocytosis (3)
- phase (3)
- phase behavior (3)
- philosophy of science (3)
- phonological development (3)
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- phospholipids (3)
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- phytoplankton communities (3)
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- pigment composition (3)
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- planets and satellites: individual (Saturn) (3)
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- plausibility (3)
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- pollination (3)
- poly(A) polymerase (3)
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- polyadenylation (3)
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- population growth rate (3)
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- potato (3)
- power spectral analysis (3)
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- pressures (3)
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- printing (3)
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- probability (3)
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- probes (3)
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- prototype-willingness-model (3)
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- pulling isometric muscle action (PIMA) (3)
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- reactance (3)
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- reading development (3)
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- real options (3)
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- rearrangement (3)
- recommendations (3)
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- recurrence analysis (3)
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- refinement (3)
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- resolution (3)
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- stars: (3)
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- ) (2)
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- 1 (2)
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- Myth-Activism (2)
- N ligands (2)
- N-2 reduction (2)
- N-carboxyanhydrid (2)
- N2 (2)
- NAB (2)
- NAC (2)
- NAC transcription factor (2)
- NAFLD/MAFLD (2)
- NAP-XPS (2)
- NASDAQ (2)
- NATO (2)
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Institut
- Institut für Biochemie und Biologie (5341)
- Institut für Physik und Astronomie (5219)
- Institut für Geowissenschaften (3532)
- Institut für Chemie (3373)
- Wirtschaftswissenschaften (2485)
- Department Psychologie (2203)
- Historisches Institut (2051)
- Sozialwissenschaften (1838)
- Institut für Mathematik (1803)
- Institut für Romanistik (1760)
Urokinase-type plasminogen activator is widely discussed as a marker for cancer prognosis and diagnosis and as a target for cancer therapies. Together with its receptor, uPA plays an important role in tumorigenesis, tumor progression and metastasis. In the present study, systematic evolution of ligands by exponential enrichment (SELEX) was used to select single-stranded DNA aptamers targeting different forms of human uPA. Selected aptamers allowed the distinction between HMW-uPA and LMW-uPA, and therefore, presumably, have different binding regions. Here, uPAapt-02-FR showed highly affine binding with a K-D of 0.7 nM for HMW-uPA and 21 nM for LMW-uPA and was also able to bind to pro-uPA with a K-D of 14 nM. Furthermore, no cross-reactivity to mouse uPA or tissue-type plasminogen activator (tPA) was measured, demonstrating high specificity. Suppression of the catalytic activity of uPA and inhibition of uPAR-binding could be demonstrated through binding with different aptamers and several of their truncated variants. Since RNA aptamers are already known to inhibit uPA-uPAR binding and other pathological functions of the uPA system, these aptamers represent a novel, promising tool not only for detection of uPA but also for interfering with the pathological functions of the uPA system by additionally inhibiting uPA activity.
We tested whether a brief self-affirmation writing intervention protected against identity-threats (i.e., stereotyping and discrimination) for adolescents' school-related adjustment. The longitudinal study followed 639 adolescents in Germany (65% of immigrant descent, 50% female, M-age = 12.35 years, SDage = .69) from 7(th) grade (pre-intervention at T1, five to six months post-intervention at T2) to the end of 8(th) grade (one-year follow-up at T3). We tested for direct and moderated (by heritage group, discrimination, classroom cultural diversity climate) effects using regression and latent change models. The self-affirmation intervention did not promote grades or math competence. However, in the short-term and for adolescents of immigrant descent, the intervention prevented a downward trajectory in mastery reactions to academic challenges for those experiencing greater discrimination. Further, it protected against a decline in behavioral school engagement for those in positive classroom cultural diversity climates. In the long-term and for all adolescents, the intervention lessened an upward trajectory in disruptive behavior. Overall, the self-affirmation intervention benefited some aspects of school-related adjustment for adolescents of immigrant and non-immigrant descent. The intervention context is important, with classroom cultural diversity climate acting as a psychological affordance enhancing affirmation effects. Our study supports the ongoing call for theorizing and empirically testing student and context heterogeneity to better understand for whom and under which conditions this intervention may work.
The Altiplano-Puna plateau, in Central Andes, is the second-largest continental plateau on Earth, extending between 22 degrees and 27 degrees S at an average altitude of 4400 m. The Puna plateau has been formed in consequence of the subduction of the oceanic Nazca Plate beneath the continental South American plate, which has an average crustal thickness of 50 km at this location. A large seismicity cluster, the Jujuy cluster, is observed at depth of 150-250 km beneath the central region of the Puna plateau. The cluster is seismically very active, with hundreds of earthquakes reported and a peak magnitude MW 6.6 on 25th August 2006. The cluster is situated in one of three band of intermediate-depth focus seismicity, which extend parallel to the trench roughly North to South. It has been hypothesized that the Jujuy cluster could be a seismic nest, a compact seismogenic region characterized by a high stationary activity relative to its surroundings. In this study, we collected more than 40 years of data from different catalogs and proof that the cluster meets the three conditions of a seismic nest. Compared to other known intermediate depth nests at Hindu Kush (Afganisthan) or Bucaramanga (Colombia), the Jujuy nest presents an outstanding seismicity rate, with more than 100 M4+ earthquakes per year. We additionally performed a detailed analysis of the rupture process of some of the largest earthquakes in the nest, by means of moment tensor inversion and directivity analysis. We focused on the time period 2017-2018, where the seismic monitoring was the most extended. Our results show that earthquakes in the nest take place within the eastward subducting oceanic plate, but rupture along sub-horizontal planes dipping westward. We suggest that seismicity at Jujuy nest is controlled by dehydration processes, which are also responsible for the generation of fluids ascending to the crust beneath the Puna volcanic region. We use the rupture plane and nest geometry to provide a constraint to maximal expected magnitude, which we estimate as MW -6.7.
Purpose:
Soil erosion by water yields sediment to surface reservoirs, reducing their storage capacities, changing their geometry, and degrading water quality. Sediment reuse, i.e., fertilization of agricultural soils with the nutrient-enriched sediment from reservoirs, has been proposed as a recovery strategy. However, the sediment needs to meet certain criteria. In this study, we characterize sediments from the densely dammed semiarid Northeast Brazil by VNIR-SWIR spectroscopy and assess the effect of spectral resolution and spatial scale on the accuracy of N, P, K, C, electrical conductivity, and clay prediction models.
Methods
Sediment was collected in 10 empty reservoirs, and physical and chemical laboratory analyses as well as spectral measurements were performed. The spectra, initially measured at 1 nm spectral resolution, were resampled to 5 and 10 nm, and samples were analysed for both high and low spectral resolution at three spatial scales, namely (1) reservoir, (2) catchment, and (3) regional scale.
Results
Partial least square regressions performed from good to very good in the prediction of clay and electrical conductivity from reservoir (<40 km(2)) to regional (82,500 km(2)) scales. Models for C and N performed satisfactorily at the reservoir scale, but degraded to unsatisfactory at the other scales. Models for P and K were more unstable and performed from unsatisfactorily to satisfactorily at all scales. Coarsening spectral resolution by up to 10 nm only slightly degrades the models' performance, indicating the potential of characterizing sediment from spectral data captured at lower resolutions, such as by hyperspectral satellite sensors.
Conclusion:
By reducing the costly and time-consuming laboratory analyses, the method helps to promote the sediment reuse as a practice of soil and water conservation.
Local laws on urban policy, i.e., ordinances directly affect our daily life in various ways (health, business etc.), yet in practice, for many citizens they remain impervious and complex. This article focuses on an approach to make urban policy more accessible and comprehensible to the general public and to government officials, while also addressing pertinent social media postings. Due to the intricacies of the natural language, ranging from complex legalese in ordinances to informal lingo in tweets, it is practical to harness human judgment here. To this end, we mine ordinances and tweets via reasoning based on commonsense knowledge so as to better account for pragmatics and semantics in the text. Ours is pioneering work in ordinance mining, and thus there is no prior labeled training data available for learning. This gap is filled by commonsense knowledge, a prudent choice in situations involving a lack of adequate training data. The ordinance mining can be beneficial to the public in fathoming policies and to officials in assessing policy effectiveness based on public reactions. This work contributes to smart governance, leveraging transparency in governing processes via public involvement. We focus significantly on ordinances contributing to smart cities, hence an important goal is to assess how well an urban region heads towards a smart city as per its policies mapping with smart city characteristics, and the corresponding public satisfaction.
Land Brandenburg
(2021)
Das über 860 Jahre alte deutsche Land BB liegt im Nordosten Ds zwischen Elbe und Oder. Es umschließt die Bundeshauptstadt BE, die als Einheitsgemeinde zugleich ein eigenes Land bildet. Potsdam als Landeshauptstadt ist mit 176.000 E. die größte Stadt in BB. Mit 29.482 qkm (8,3 % von D) zählt die Mark zu den flächenreichsten Bundesländern.
This special issue, "Concrete constraints of abstract concepts", addresses the role of concrete determinants, both external and internal to the human body, in acquisition, processing and use of abstract concepts while at the same time presenting to the readers an overview of methods used to assess their representation.
After a century of semi-restricted floodplain development, Southern Alberta, Canada, was struck by the devastating 2013 Flood. Aging infrastructure and limited property-level floodproofing likely contributed to the $4-6 billion (CAD) losses. Following this catastrophe, Alberta has seen a revival in flood management, largely focused on structural protections. However, concurrent with the recent structural work was a 100,000+ increase in Calgary's population in the 5 years following the flood, leading to further densification of high-hazard areas. This study implements the novel Stochastic Object-based Flood damage Dynamic Assessment (SOFDA) model framework to quantify the progression of the direct-damage flood risk in a mature urban neighborhood after the 2013 Flood. Five years of remote-sensing data, property assessment records, and inundation simulations following the flood are used to construct the model. Results show that in these 5 years, vulnerability trends (like densification) have increased flood risk by 4%; however, recent structural mitigation projects have reduced overall flood risk by 47% for this case study. These results demonstrate that the flood management revival in Southern Alberta has largely been successful at reducing flood risk; however, the gains are under threat from continued development and densification absent additional floodproofing regulations.
Background The Berlin Fat Mouse Inbred line (BFMI) is a model for obesity and the metabolic syndrome. This study aimed to identify genetic variants associated with impaired glucose metabolism using the obese lines BFMI861-S1 and BFMI861-S2, which are genetically closely related, but differ in several traits. BFMI861-S1 is insulin resistant and stores ectopic fat in the liver, whereas BFMI861-S2 is insulin sensitive. Methods In generation 10, 397 males of an advanced intercross line (AIL) BFMI861-S1 x BFMI861-S2 were challenged with a high-fat, high-carbohydrate diet and phenotyped over 25 weeks. QTL-analysis was performed after selective genotyping of 200 mice using the GigaMUGA Genotyping Array. Additional 197 males were genotyped for 7 top SNPs in QTL regions. For the prioritization of positional candidate genes whole genome sequencing and gene expression data of the parental lines were used. Results Overlapping QTL for gonadal adipose tissue weight and blood glucose concentration were detected on chromosome (Chr) 3 (95.8-100.1 Mb), and for gonadal adipose tissue weight, liver weight, and blood glucose concentration on Chr 17 (9.5-26.1 Mb). Causal modeling suggested for Chr 3-QTL direct effects on adipose tissue weight, but indirect effects on blood glucose concentration. Direct effects on adipose tissue weight, liver weight, and blood glucose concentration were suggested for Chr 17-QTL. Prioritized positional candidate genes for the identified QTL were Notch2 and Fmo5 (Chr 3) and Plg and Acat2 (Chr 17). Two additional QTL were detected for gonadal adipose tissue weight on Chr 15 (67.9-74.6 Mb) and for body weight on Chr 16 (3.9-21.4 Mb). Conclusions QTL mapping together with a detailed prioritization approach allowed us to identify candidate genes associated with traits of the metabolic syndrome. In addition, we provided evidence for direct and indirect genetic effects on blood glucose concentration in the insulin-resistant mouse line BFMI861-S1.
Biodegradation of polyester polyurethane by the marine fungus Cladosporium halotolerans 6UPA1
(2022)
Lack of degradability and the accumulation of polymeric wastes increase the risk for the health of the environment. Recently, recycling of polymeric waste materials becomes increasingly important as raw materials for polymer synthesis are in short supply due to the rise in price and supply chain disruptions. As an important polymer, polyurethane (PU) is widely used in modern life, therefore, PU biodegradation is desirable to avoid its accumulation in the environment. In this study, we isolated a fungal strain Cladosporium halotolerans from the deep sea which can grow in mineral medium with a polyester PU (Impranil DLN) as a sole carbon source. Further, we demonstrate that it can degrade up to 80% of Impranil PU after 3 days of incubation at 28 celcius by breaking the carbonyl groups (1732 cm(-1)) and C-N-H bonds (1532 cm(-1) and 1247 cm(-1)) as confirmed by Fourier-transform infrared (FTIR) spectroscopy analysis. Gas chromatography-mass spectrometry (GC-MS) analysis revealed polyols and alkanes as PU degradation intermediates, indicating the hydrolysis of ester and urethane bonds. Esterase and urease activities were detected in 7 days-old cultures with PU as a carbon source. Transcriptome analysis showed a number of extracellular protein genes coding for enzymes such as cutinase, lipase, peroxidase and hydrophobic surface binding proteins A (HsbA) were expressed when cultivated on Impranil PU. The yeast two-hybrid assay revealed that the hydrophobic surface binding protein ChHsbA1 directly interacts with inducible esterases, ChLip1 (lipase) and ChCut1 (cutinase). Further, the KEGG pathway for "fatty acid degradation " was significantly enriched in Impranil PU inducible genes, indicating that the fungus may use the degradation intermediates to generate energy via this pathway. Taken together, our data indicates secretion of both esterase and hydrophobic surface binding proteins by C. halotolerans plays an important role in Impranil PU absorption and subsequent degradation. Our study provides a mechanistic insight into Impranil PU biodegradation by deep sea fungi and provides the basis for future development of biotechnological PU recycling.
VLDB 2021
(2021)
The 47th International Conference on Very Large Databases (VLDB'21) was held on August 16-20, 2021 as a hybrid conference. It attracted 180 in-person attendees in Copenhagen and 840 remote attendees. In this paper, we describe our key decisions as general chairs and program committee chairs and share the lessons we learned.
FicucariconeD (1) and its 4 '-demethyl congener 2 are isoflavones isolated from fruits of Ficus carica that share a 5,7-dimethoxy-6-prenyl-substituted A-ring. Both naturalproducts were, for the first time, obtained by chemical synthesisin six steps, starting from 2,4,6-trihydroxyacetophenone. Key stepsare a microwave-promoted tandem sequence of Claisen- and Cope-rearrangementsto install the 6-prenyl substituent and a Suzuki-Miyaura crosscoupling for installing the B-ring. By using various boronic acids,non-natural analogues become conveniently available. All compoundswere tested for cytotoxicity against drug-sensitive and drug-resistanthuman leukemia cell lines, but were found to be inactive. The compoundswere also tested for antimicrobial activities against a panel of eightGram-negative and two Gram-positive bacterial strains. Addition ofthe efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide(PA beta N) significantly improved the antibiotic activity in mostcases, with MIC values as low as 2.5 mu M and activity improvementfactors as high as 128-fold.
To systematically add functionality to nanoscale polymer switches, an understanding of their responsive behavior is crucial. Herein, solvent vapor stimuli are applied to thin films of a diblock copolymer consisting of a short poly(methyl methacrylate) (PMMA) block and a long poly(N-isopropylmethacrylamide) (PNIPMAM) block for realizing ternary nanoswitches. Three significantly distinct film states are successfully implemented by the combination of amphiphilicity and co-nonsolvency effect. The exposure of the thin films to nitrogen, pure water vapor, and mixed water/acetone (90 vol%/10 vol%) vapor switches the films from a dried to a hydrated (solvated and swollen) and a water/acetone-exchanged (solvated and contracted) equilibrium state. These three states have distinctly different film thicknesses and solvent contents, which act as switch positions "off," "on," and "standby." For understanding the switching process, time-of-flight neutron reflectometry (ToF-NR) and spectral reflectance (SR) studies of the swelling and dehydration process are complemented by information on the local solvation of functional groups probed with Fourier-transform infrared (FTIR) spectroscopy. An accelerated responsive behavior beyond a minimum hydration/solvation level is attributed to the fast build-up and depletion of the hydration shell of PNIPMAM, caused by its hydrophobic moieties promoting a cooperative hydration character.
Introduction:
Decision making results not only from logical analyses, but seems to be further guided by the ability to perceive somatic information (interoceptive accuracy). Relations between interoceptive accuracy and decision making have been exclusively studied in adults and with regard to complex, uncertain situations (as measured by the Iowa Gambling Task, IGT).
Methods:
In the present study, 1454 children (6-11 years) were examined at two time points (approximately 1 year apart) using an IGT as well as a delay-of-gratification task for sweets-items and toy-items. Interoceptive accuracy was measured using a child-adapted version of the Heartbeat Perception Task.
Results:
The present results revealed that children with higher, as compared to lower, interoceptive accuracy showed more advantageous choices in the IGT and delayed more sweets-items, but not toy-items, in a delay-of-gratification task at time point 2 but not at time point 1. However, no longitudinal relation between interoceptive accuracy and decision making 1 year later could be shown.
Discussion:
Results indicate that interoceptive accuracy relates to decision-making abilities in situations of varying complexity already in middle childhood, and that this link might consolidate across the examined 1-year period. Furthermore, the association of interoceptive accuracy and the delay of sweets-items might have implications for the regulation of body weight at a later age.
This study evaluates the challenges, institutional impacts and responses of German local authorities to the COVID-19 pandemic from a political science point of view. The main research question is how they have contributed to combat the COVID-19 pandemic and to what extent the strengths and weaknesses of the German model of municipal autonomy have influenced their policy. It analyses the adaptation strategies of German local authorities and assesses the effectiveness of their actions up to now. Their implementation is then evaluated in five selected issues, e.g. adjustment organization and staff, challenges for local finances, local politics and citizen’s participation. This analysis is reflecting the scientific debate in Germany since the beginning of 2020, based on the available analyses of political science, law, economics, sociology and geography until end of March 2021.
Weathering the storm?
(2023)
Democratization scholars are currently debating if we are indeed witnessing a third wave of autocratization. While this has led to an extensive debate about the future of the liberal international order, we still know relatively little about the consequences of autocratization for international organizations (IOs). In this article, we explore to what extent autocratization has led to changes in the composition of IO membership. We propose three different ways of conceptualizing autocratization of IO membership. We argue that we should move away from a dichotomous understanding of regime type and regime change, but rather focus on composition of subregime types to understand current developments. We build on updated membership data for 73 IOs through 2020 to map membership configurations based on the V-Dem Electoral Democracy Index. Contrary to current debates on the crisis of the liberal order, we find that many IOs are not (yet) affected by broad autocratization of their membership that would endanger democratic majorities or overall democratic densities. However, we also observe the disappearance of formerly homogenous democratic clubs due to democratic backsliding in a number of European and Latin American IO member states, as well as a return of autocratic clubs in Southeast Asia and Southern Africa. These findings have important implications for the broader research agenda on international democracy promotion and human right protection as well as the study of legitimacy and the effectiveness of international organizations.
Reference values and validation of the 1-minute sit-to-stand test in healthy 5-16-year-old youth
(2021)
Objectives:
It is essential to have simple, reliable and valid tests to measure children's functional capacity in schools or medical practice. The 1-minute sit-to-stand (STS) test is a quick fitness test requiring little equipment or space that is increasingly used in both healthy populations and those with chronic disease. We aimed to provide age-specific and sex-specific reference values of STS test in healthy children and adolescents and to evaluate its short-term reliability and construct validity.
Design setting and participants:
Cross-sectional convenience sample from six public schools and one science fair in central Europe. Overall, 587 healthy participants aged 5-16 years were recruited and divided into age groups of 3 years each.
Outcomes:
1-minute STS. To evaluate short-term reliability, some children performed the STS test twice. To evaluate construct validity, some children also performed a standing long jump (SLJ) and a maximal incremental exercise test.
Results:
Data from 547 youth aged 5-16 years were finally included in the analyses. The median number of repetitions in 1 min in males (females) ranged from 55 [95% CI: 38 to 72] (53 [95% CI: 35 to 76]) in 14-16-year olds to 59 [95% CI: 41 to 77] (60 [95% CI: 38 to 77]) in 8-10-year olds. Children who repeated STS showed a learning effect of on average 4.8 repetitions more than the first test (95% limits of agreement: -6.7 to 16.4). Moderate correlations were observed between the STS and the SLJ (r=0.48) tests and the maximal exercise test (r=0.43).
Conclusions:
The reported STS reference values can be used to interpret STS test performance in children and adolescents. The STS appears to have good test- retest reliability, but a learning effect of about 10%. The association of STS with other measures of physical fitness should be further explored in a larger study and technical standards for its conduct are needed.
Urban surface runoff management via best management practices (BMP) and low impact development (LID) has earned significant recognition owing to positive environmental and ecological impacts. However, due to the complexity of the parameters involved, the estimation of LID efficiency in attenuating the urban surface runoff at the watershed scale is challenging. A planning analysis of employing Green Roofs and Infiltration Trenches as BMPs/LIDs practices for urban surface runoff control is presented in this study. A multi-objective optimization decision-making framework is established by coupling SWMM (Storm Water Management Model) with NSGA-II models to check the performance of BMPs/LIDs concerning the cost-benefit analysis of LID at the watershed scale. Two urbanized areas belonging to Central Delhi in India were used as case studies. The results showed that the SWMM model is useful in simulating optimization problems for managing urban surface runoff. The optimum scenarios efficiently minimized the urban runoff volume while maintaining the BMPs/LIDs implementation costs and size. With BMPs/LIDs implementation, the reduction in runoff volume increases as expenses increase initially; however, there is no noticeable reduction in flood volume after a certain threshold. Contrasted with the haphazard arrangement of BMPs/LIDs, the proposed approach demonstrates 22%-24% runoff reductions for the same expenditures in watershed 1 and 23%-26% in watershed 2. The result of the study provides insights into planning and management of the urban surface runoff control with LID practices. The proposed framework assists the hydrologists in optimum selection and placements of BMPs/LIDs practices to acquire the most extreme ecological advantages with the least expenses.
The current paradigm of cosmic-ray (CR) origin states that the greater part of galactic CRs is produced by supernova remnants. The interaction of supernova ejecta with the interstellar medium after a supernova's explosions results in shocks responsible for CR acceleration via diffusive shock acceleration (DSA). We use particle-in-cell (PIC) simulations and a combined PIC-magnetohydrodynamic (PIC-MHD) technique to investigate whether DSA can occur in oblique high Mach number shocks. Using the PIC method, we follow the formation of the shock and determine the fraction of the particles that gets involved in DSA. With this result, we use PIC-MHD simulations to model the large-scale structure of the plasma and the magnetic field surrounding the shock and find out whether or not the reflected particles can generate upstream turbulence and trigger DSA. We find that the feasibility of this process in oblique shocks depends strongly on the Alfvenic Mach number, and the DSA process is more likely to be triggered at high Mach number shocks.
Van Allen Probes measurements revealed the presence of the most unusual structures in the ultra-relativistic radiation belts. Detailed modeling, analysis of pitch angle distributions, analysis of the difference between relativistic and ultra-realistic electron evolution, along with theoretical studies of the scattering and wave growth, all indicate that electromagnetic ion cyclotron (EMIC) waves can produce a very efficient loss of the ultra-relativistic electrons in the heart of the radiation belts. Moreover, a detailed analysis of the profiles of phase space densities provides direct evidence for localized loss by EMIC waves. The evolution of multi-MeV fluxes shows dramatic and very sudden enhancements of electrons for selected storms. Analysis of phase space density profiles reveals that growing peaks at different values of the first invariant are formed at approximately the same radial distance from the Earth and show the sequential formation of the peaks from lower to higher energies, indicating that local energy diffusion is the dominant source of the acceleration from MeV to multi-MeV energies. Further simultaneous analysis of the background density and ultra-relativistic electron fluxes shows that the acceleration to multi-MeV energies only occurs when plasma density is significantly depleted outside of the plasmasphere, which is consistent with the modeling of acceleration due to chorus waves.
As a critical part of plant immunity, cells that are attacked by pathogens undergo rapid transcriptional reprogramming to minimize virulence. Many bacterial phytopathogens use type III effector (T3E) proteins to interfere with plant defense responses, including this transcriptional reprogramming. Here, we show that Xanthomonas outer protein S (XopS), a T3E of Xanthomonas campestris pv. vesicatoria (Xcv), interacts with and inhibits proteasomal degradation of WRKY40, a transcriptional regulator of defense gene expression. Virus-induced gene silencing of WRKY40 in pepper (Capsicum annuum) enhanced plant tolerance to Xcv infection, indicating that WRKY40 represses immunity. Stabilization of WRKY40 by XopS reduces the expression of its targets, which include salicylic acid-responsive genes and the jasmonic acid signaling repressor JAZ8. Xcv bacteria lacking XopS display significantly reduced virulence when surface inoculated onto susceptible pepper leaves. XopS delivery by Xcv, as well as ectopic expression of XopS in Arabidopsis thaliana or Nicotiana benthamiana, prevented stomatal closure in response to bacteria and biotic elicitors. Silencing WRKY40 in pepper or N. benthamiana abolished XopS's ability to prevent stomatal closure. This suggests that XopS interferes with both preinvasion and apoplastic defense by manipulating WRKY40 stability and downstream gene expression, eventually altering phytohormone crosstalk to promote pathogen proliferation.
Die Übertretung von bußgeldbewehrten Verkehrsregeln bei Fahrten, die der Abwehr einer Gefahr – z. B. der Verbringung einer schwer verletzten oder erkrankten Person in eine Klinik – dienen, ist ein alltäglicher Vorgang. Polizei, Feuerwehr, Notarzt und andere institutionelle Retter sind von der Einhaltung der Regeln gemäß § STVO § 35 StVO dispensiert und begehen keine Ordnungswidrigkeiten. Privatpersonen haben diese Sonderrechte nicht und entgehen der Ahndbarkeit nur unter den Voraussetzungen eines Rechtfertigungs- oder Vorwerfbarkeitsausschlussgrundes. Vor allem der rechtfertigende Notstand (§ OWIG § 16 OWiG) hat große praktische Bedeutung. Diese Norm steht im Mittelpunkt der Entscheidung des OLG Düsseldorf. Der zugrundeliegende Fall wirft aber noch weitere interessante Rechtsfragen auf.
We present two new empirical models of radiation belt electron flux at geostationary orbit. GOES-15 measurements of 0.8 MeV electrons were used to train a Nonlinear Autoregressive with Exogenous input (NARX) neural network for both modeling GOES-15 flux values and an upper boundary condition scaling factor (BF). The GOES-15 flux model utilizes an input and feedback delay of 2 and 2 time steps (i.e., 5 min time steps) with the most efficient number of hidden layers set to 10. Magnetic local time, Dst, Kp, solar wind dynamic pressure, AE, and solar wind velocity were found to perform as predicative indicators of GOES-15 flux and therefore were used as the exogenous inputs. The NARX-derived upper boundary condition scaling factor was used in conjunction with the Versatile Electron Radiation Belt (VERB) code to produce reconstructions of the radiation belts during the period of July-November 1990, independent of in-situ observations. Here, Kp was chosen as the sole exogenous input to be more compatible with the VERB code. This Combined Release and Radiation Effects Satellite-era reconstruction showcases the potential to use these neural network-derived boundary conditions as a method of hindcasting the historical radiation belts. This study serves as a companion paper to another recently published study on reconstructing the radiation belts during Solar Cycles 17-24 (Saikin et al., 2021, ), for which the results featured in this paper were used.
Regional flood frequency analysis (RFFA) is a powerful method for interrogating hydrological series since it combines observational time series from several sites within a region to estimate risk-relevant statistical parameters with higher accuracy than from single-site series. Since RFFA extreme value estimates depend on the shape of the selected distribution of the data-generating stochastic process, there is need for a suitable goodness-of-distributional-fit measure in order to optimally utilize given data. Here we present a novel, least-squares-based measure to select the optimal fit from a set of five distributions, namely Generalized Extreme Value (GEV), Generalized Logistic, Gumbel, Log-Normal Type III and Log-Pearson Type III. The fit metric is applied to annual maximum discharge series from six hydrological stations along the Sava River in South-eastern Europe, spanning the years 1961 to 2020. Results reveal that (1) the Sava River basin can be assessed as hydrologically homogeneous and (2) the GEV distribution provides typically the best fit. We offer hydrological-meteorological insights into the differences among the six stations. For the period studied, almost all stations exhibit statistically insignificant trends, which renders the conclusions about flood risk as relevant for hydrological sciences and the design of regional flood protection infrastructure.
Climate Benefits of Cleaner Energy Transitions in East and South Asia Through Black Carbon Reduction
(2022)
The state of air pollution has historically been tightly linked to how we produce and use energy. Air pollutant emissions over Asia are now changing rapidly due to cleaner energy transitions; however, magnitudes of benefits for climate and air quality remain poorly quantified. The associated risks involve adverse health impacts, reduced agricultural yields, reduced freshwater availability, contributions to climate change, and economic costs. We focus particularly on climate benefits of energy transitions by making first-time use of two decades of high quality observations of atmospheric loading of light-absorbing black carbon (BC) over Kanpur (South Asia) and Beijing (East Asia) and relating these observations to changing energy, emissions, and economic trends in India and China. Our analysis reveals that absorption aerosol optical depth (AAOD) due to BC has decreased substantially, by 40% over Kanpur and 60% over Beijing between 2001 and 2017, and thus became decoupled from regional economic growth. Furthermore, the resultant decrease in BC emissions and BC AAOD over Asia is regionally coherent and occurs primarily due to transitions into cleaner energies (both renewables and fossil fuels) and not due to the decrease in primary energy supply or decrease in use of fossil use and biofuels and waste. Model simulations show that BC aerosols alone contribute about half of the surface temperature change (warming) of the total forcing due to greenhouse gases, natural and internal variability, and aerosols, thus clearly revealing the climate benefits due to a reduction in BC emissions, which would significantly reduce global warming. However, this modeling study excludes responses from natural variability, circulation, and sea ice responses, which cause relatively strong temperature fluctuations that may mask signals from BC aerosols. Our findings show additional benefits for climate (beyond benefits of CO2 reduction) and for several other issues of sustainability over South and East Asia, provide motivation for ongoing cleaner energy production, and consumption transitions, especially when they are associated with reduced emissions of air pollutants. Such an analysis connecting the trends in energy transitions and aerosol absorption loading, unavailable so far, is crucial for simulating the aerosol climate impacts over Asia which is quite uncertain.
Enhancing higher entrepreneurship education: insights from practitioners for curriculum improvement
(2024)
Curricula for higher entrepreneurship education should meet the requirements of both a solid theoretical foundation and a practical orientation. When these curricula are designed by education specialists, entrepreneurs are usually not consulted. To explore practitioners’ curricular recommendations, we conducted 73 semi-structured interviews with entrepreneurs with at least five years of professional experience. We collected 49 items for teaching and learning objectives, 37 for contents, 28 for teaching methods, and 17 for assessment methods. The respondents are convinced that students should acquire solid knowledge in business and management, legal issues, and entrepreneurship. For the latter, only some core aspects are provided. The entrepreneurs put greater emphasis on entrepreneurial skills and attitudes and consider experiential learning designs as most suitable, both in the secure setting of the classroom and in real life. The findings can help reflect on current entrepreneurship curriculum designs.
„Die Gefahr eines Blackouts ist gegeben“ gab der Vorsitzende des Deutschen Städte- und Gemeindebundes (DStGB), Gerd Landsberg, am 15. September 2022 in einem Interview mit der Welt am Sonntag bekannt. Diese Diagnose – hier bezogen auf mögliche Engpässe in der Energieversorgung im Winter 2022/23, die durch den kriegerischen Angriff Russlands auf die Ukraine zu drohen scheinen – reiht sich einer weiteren Perle gleich in die lange Kette unzähliger Krisendiagnosen der letzten Dekade ein, angesichts derer sich zunehmend der Eindruck einstellen muss, die Krise sei so etwas wie der neue Normalzustand. So ist seit etwas mehr als zehn Jahren die Klimakrise in aller Munde, die letzten drei Jahre wurden von der Corona-Krise dominiert, eine Energiekrise steht möglicherweise unmittelbar bevor.
Demokratie und politische Bildung stehen in einem sich zugewandten Verhältnis. Doch folgt daraus, dass politische Urteile stets demokratisch sein müssen? Der Beitrag diskutiert diese Frage vor dem Hintergrund der derzeitigen Debatte um antidemokratische Bewegungen in der Gesellschaft, der Rolle politischer Bildung als Förderin von Demokratie und der individuellen Herausforderung für Lehrpersonen in der Unterrichtspraxis.
Qualitative Inhaltsanalyse
(2021)
Die qualitative Inhaltsanalyse dient als Auswertungsinstrument für Textmaterial, kann aber auch für die Analyse von Ton- und Bildmaterial genutzt werden. Anders als die quantitative Inhaltsanalyse zielt sie darauf ab, dem Material auch Informationen zu entnehmen, auf die ausschließlich interpretativ geschlossen werden kann. Die qualitative Inhaltsanalyse knüpft an die hermeneutische Tradition des Verstehens an. Der Verstehensprozess wird jedoch in einen vordefinierten, theorie- und regelgeleiteten Forschungsablauf gebettet, um dem wissenschaftlichen Anspruch an Systematik und Intersubjektivität nachzukommen.
The analysis of event time series is in general challenging. Most time series analysis tools are limited for the analysis of this kind of data. Recurrence analysis, a powerful concept from nonlinear time series analysis, provides several opportunities to work with event data and even for the most challenging task of comparing event time series with continuous time series. Here, the basic concept is introduced, the challenges are discussed, and the future perspectives are summarized.
A detailed investigation of the energy levels of perylene-3,4,9,10-tetracarboxylic tetraethylester as a representative compound for the whole family of perylene esters was performed. It was revealed via electrochemical measurements that one oxidation and two reductions take place. The bandgaps determined via the electrochemical approach are in good agreement with the optical bandgap obtained from the absorption spectra via a Tauc plot. In addition, absorption spectra in dependence of the electrochemical potential were the basis for extensive quantum-chemical calculations of the neutral, monoanionic, and dianionic molecules. For this purpose, calculations based on density functional theory were compared with post-Hartree-Fock methods and the CAM-B3LYP functional proved to be the most reliable choice for the calculation of absorption spectra. Furthermore, spectral features found experimentally could be reproduced with vibronic calculations and allowed to understand their origins. In particular, the two lowest energy absorption bands of the anion are not caused by absorption of two distinct electronic states, which might have been expected from vertical excitation calculations, but both states exhibit a strong vibronic progression resulting in contributions to both bands.
Invisible iterations: how formal and informal organization shape knowledge networks for coordination
(2024)
This study takes a network approach to investigate coordination among knowledge workers as grounded in both formal and informal organization. We first derive hypotheses regarding patterns of knowledge-sharing relationships by which workers pass on and exchange tacit and codified knowledge within and across organizational hierarchies to address the challenges that underpin contemporary knowledge work. We use survey data and apply exponential random graph models to test our hypotheses. We then extend the quantitative network analysis with insights from qualitative interviews and demonstrate that the identified knowledge-sharing patterns are the micro-foundational traces of collective coordination resulting from two underlying coordination mechanisms which we label ‘invisible iterations’ and ‘bringing in the big guns’. These mechanisms and, by extension, the associated knowledge-sharing patterns enable knowledge workers to perform in a setting that is characterized by complexity, uncertainty and ambiguity. Our research contributes to theory on the interplay between formal and informal organization for coordination by showing how self-directed, informal action is supported by the formal organizational hierarchy. In doing so, it also extends understanding of the role that hierarchy plays for knowledge-intensive work. Finally, it establishes the collective need to coordinate work as a previously overlooked driver of knowledge network relationships and network patterns. © 2024 The Authors. Journal of Management Studies published by Society for the Advancement of Management Studies and John Wiley & Sons Ltd.
We have analysed an archival XMM-Newton EPIC observation that serendipitously covered the sky position of a variable X-ray source AX J1714.1-3912, previously suggested to be a Supergiant Fast X-ray Transient (SFXT). During the XMM-Newton observation the source is variable on a timescale of hundred seconds and shows two luminosity states, with a flaring activity followed by unflared emission, with a variability amplitude of a factor of about 50. We have discovered an intense iron emission line with a centroid energy of 6.4 keV in the power law-like spectrum, modified by a large absorption (N-H similar to 10(24) cm(-2)), never observed before from this source. This X-ray spectrum is unusual for an SFXT, but resembles the so-called 'highly obscured sources', high mass X-ray binaries (HMXBs) hosting an evolved B[e] supergiant companion (sgB[e]). This might suggest that AX J1714.1-3912 is a new member of this rare type of HMXBs, which includes IGR J16318-4848 and CI Camelopardalis. Increasing this small population of sources would be remarkable, as they represent an interesting short transition evolutionary stage in the evolution of massive binaries. Nevertheless, AX J1714.1-3912 appears to share X-ray properties of both kinds of HMXBs (SFXT versus sgB[e] HMXB). Therefore, further investigations of the companion star are needed to disentangle the two hypothesis.
Even though the effects of insect pests on global agricultural productivity are well recognised, little is known about movement and dispersal of many species, especially in the context of global warming. This work evaluates how temperature and light conditions affect different movement metrics and the feeding rate of the large lupine beetle, an agricultural pest responsible for widespread damage in leguminous crops. By using video recordings, the movement of 384 beetles was digitally analysed under six different temperatures and light conditions in the laboratory. Bayesian linear mixed-effect models were used to analyse the data. Furthermore, the effects of temperature on the daily diffusion coefficient of beetles were estimated by using hidden Markov models and random walk simulations. Results of this work show that temperature, light conditions, and beetles' weight were the main factors affecting the flight probability, displacement, time being active and the speed of beetles. Significant variations were also observed in all evaluated metrics. On average, beetles exposed to light conditions and higher temperatures had higher mean speed and flight probability. However, beetles tended to stay more active at higher temperatures and less active at intermediate temperatures, around 20 degrees C. Therefore, both the diffusion coefficient and displacement of beetles were lower at intermediate temperatures. These results show that the movement behaviour and feeding rates of beetles can present different relationships in the function of temperature. It also shows that using a single diffusion coefficient for insects in spatially explicit models may lead to over- or underestimation of pest spread.
Vibrational relaxation of adsorbates is a sensitive tool to probe energy transfer at gas/solid and liquid/solid interfaces. The most direct way to study relaxation dynamics uses time-resolved spectroscopy. Here we report on a non-equilibrium ab initio molecular dynamics (NE-AIMD) methodology to model vibrational relaxation of OH vibrations on a hydroxylated, water-covered alpha-Al2O3(0001) surface. In our NE-AIMD approach, after exciting selected O-H bonds their coupling to surface phonons and to the water adlayer is analyzed in detail, by following both the energy flow in time, as well as the time-evolution of Vibrational Density of States (VDOS) curves. The latter are obtained from Time-dependent Correlation Functions (TCFs) and serve as prototypical, generic representatives of time-resolved vibrational spectra. As most important results, (i) we find a few-picosecond lifetime of the excited modes and (ii) identify both hydrogen-bonded aluminols and water molecules in the adsorbed water layer as main dissipative channels, while the direct coupling to Al2O3 surface phonons is of minor importance on the timescales of interest. Our NE-AIMD/TCF methodology is powerful for complex adsorbate systems, in principle even reacting ones, and opens a way towards time-resolved vibrational spectroscopy.
Phase equilibria that are relevant for the growth of Bi2MO4 have been studied experimentally, and the ternary phase diagrams of Bi2O3-PdO2-Pd and Bi2O3-Cu2O-CuO and its isopleth section Bi2O3-CuO were redetermined. It is shown that every melting and crystallization process is always accompanied by a redox process at the phase boundary and that for both title compounds, the valence of the transition metal is lowered during melting. Vice versa, during crystal growth, O-2 must be transported through the melt to the phase boundary. Based on these new insights provided by our thermodynamic studies, Bi2CuO4 single crystals with a length of up to 7 cm and a diameter of 6 mm were grown by the OFZ technique to be used for investigations of magnetic, electronic and thermal transport properties. The grown crystals were characterized by powder X-ray diffraction, Laue, magnetization and specific heat measurements.
Elucidation of the reaction mechanism for the synthesis of ZnGeN2 through Zn2GeO4 ammonolysis
(2021)
Ternary II-IV-N-2 materials have been considered as a promising class of materials that combine photovoltaic performance with earth-abundance and low toxicity. When switching from binary III-V materials to ternary II-IV-N-2 materials, further structural complexity is added to the system that may influence its optoelectronic properties. Herein, we present a systematic study of the reaction of Zn2GeO4 with NH3 that produces zinc germanium oxide nitrides, and ultimately approach stoichiometric ZnGeN2, using a combination of chemical analyses, X-ray powder diffraction and DFT calculations. Elucidating the reaction mechanism as being dominated by Zn and O extrusion at the later reaction stages, we give an insight into studying structure-property relationships in this emerging class of materials.
This study deals with the facile synthesis of Fe1-xS nanoparticle-containing nitrogen-doped porous carbon membranes (denoted as Fe1-xS/N-PCMs) via vacuum carbonization of hybrid porous poly(ionic liquid) (PIL) membranes, and their successful use as a sulfur host material to mitigate the shuttle effect in lithium-sulfur (Li-S) batteries. The hybrid porous PIL membranes as the sacrificial template were prepared via ionic crosslinking of a cationic PIL with base-neutralized 1,1 '-ferrocenedicarboxylic acid, so that the iron source was molecularly incorporated into the template. The carbonization process was investigated in detail at different temperatures, and the chemical and porous structures of the carbon products were comprehensively analyzed. The Fe1-xS/N-PCMs prepared at 900 degrees C have a multimodal pore size distribution with a satisfactorily high surface area and well-dispersed iron sulfide nanoparticles to physically and chemically confine the LiPSs. The sulfur/Fe1-xS/N-PCM composites were then tested as electrodes in Li-S batteries, showing much improved capacity, rate performance and cycle stability, in comparison to iron sulfide-free, nitrogen-doped porous carbon membranes.
International institutions are an essential driving force of contemporary policies to combat gender-based violence but remain toothless if political actors do not implement them in domestic policies. How can scholars conceptualise the transposition of international gender-based violence norms into domestic policies? I argue that discourse network analysis provides a powerful conceptual and methodological extension of critical frame analysis to understand how frames shape the meaning of gender-based violence norms in multi-level institutional contexts. Frames’ normative and cognitive network structure invites combining discourse network and frame analysis techniques that locate frames’ power in their ability to connect different institutional spheres temporally and spatially. I outline a multi-level research agenda that traces the framing processes of international norms and their domestic implementation through gender-based violence policies in the Council of Europe’s Istanbul Convention. This agenda includes avenues to study how complex transnational policy frameworks like the Istanbul Convention play out in domestic policy implementation.
(1) Background:
Adaptive diversification of complex traits plays a pivotal role in the evolution of organismal diversity. In the freshwater snail genus Tylomelania, adaptive radiations were likely promoted by trophic specialization via diversification of their key foraging organ, the radula.
(2) Methods:
To investigate the molecular basis of radula diversification and its contribution to lineage divergence, we used tissue-specific transcriptomes of two sympatric Tylomelania sarasinorum ecomorphs.
(3) Results:
We show that ecomorphs are genetically divergent lineages with habitat-correlated abundances. Sequence divergence and the proportion of highly differentially expressed genes are significantly higher between radula transcriptomes compared to the mantle and foot. However, the same is not true when all differentially expressed genes or only non-synonymous SNPs are considered. Finally, putative homologs of some candidate genes for radula diversification (hh, arx, gbb) were also found to contribute to trophic specialization in cichlids and Darwin's finches.
(4) Conclusions:
Our results are in line with diversifying selection on the radula driving Tylomelania ecomorph divergence and indicate that some molecular pathways may be especially prone to adaptive diversification, even across phylogenetically distant animal groups.
Most image restoration methods in astronomy rely upon probabilistic tools that infer the best solution for a deconvolution problem. They achieve good performances when the point spread function (PSF) is spatially invariant in the image plane.
However, this condition is not always satisfied in real optical systems. We propose a new method for the restoration of images affected by static and anisotropic aberrations using Deep Neural Networks that can be directly applied to sky images.
The network is trained using simulated sky images corresponding to the T80-S Telescope optical model, a 80-cm survey imager at Cerro Tololo (Chile), which are synthesized using a Zernike polynomial representation of the optical system.
Once trained, the network can be used directly on sky images, outputting a corrected version of the image that has a constant and known PSF across its field of view. The method is to be tested on the T80-S Telescope.
We present the method and results on synthetic data.
Background:
Aphasia therapy software applications (apps) can help achieve recommendations regarding aphasia treatment intensity and duration.
However, we currently know very little about speech and language therapists' (SLTs) preferences with regards to these apps.
This may be problematic, as clinician acceptance of novel treatments and technology are a key factor for successful translation from research evidence to practice.
Aim:
This research aimed to increase our understanding of clinicians' experiences with aphasia therapy apps and their perceived barriers and facilitators to the use of aphasia apps. Furthermore, we wanted to explore the influence of some demographic factors (age, country, and SLT availability in the client's hometown) on SLTs' attitudes towards these apps.
Method & Procedures:
35 Dutch and 29 Australian SLTs completed an online survey. The survey contained 9 closed-ended questions and 3 open-ended questions. Responses to the closed-ended questions were summarised through the use of descriptive statistics. The responses to the open questions were analysed and coded into recurring themes that were derived from the data. Logistic regression analyses were performed to explore the relationship between the demographic variables and the responses to the closed-ended questions.
Outcomes & results:
Participants were overwhelmingly positive about aphasia therapy apps and saw the potential for their clients to use apps independently. As facilitators of app use, participants reported accessibility and inclusion of different language modalities, while high costs, absence of a compatible device, and clients' potential computer illiteracy were listed as barriers. None of the analysed demographic factors consistently influenced differences in participants' attitudes towards aphasia therapy apps.
Conclusions:
The positive, extensive and insightful feedback from speech and language therapists is both useful and encouraging for app developers and aphasia researchers, and should facilitate the development of appropriate, high-quality therapy apps.
After some seventy years of intensive debates, there is an increasingly strong consensus within the academic and practitioner communities that development is both an objective and a process towards improving the quality of people's lives in various societal dimensions – economic, social, environmental, cultural and political – and about how subjectively satisfied they are with it. Since 2015, the seventeen Sustainable Development Goals (SDGs) of the United Nations (UN) reflect such consensus. The sections behind this argument are based on a review of (i) three key theoretical contributions to development and different phases of development thinking; (ii) global and regional governance arrangements and institutions for development cooperation; (iii) upcoming challenges to development policy and practice stemming from a series of new global challenges; and, (iv) development policy as a long and steady, increasingly global and participatory learning process.
Im Lehramtsstudium sollen Studierende grundlegende Fähigkeiten zur theoriegeleiteten Unterrichtsplanung erwerben.
In Übereinstimmung mit Modellen zur professionellen Handlungskompetenz von Lehrkräften wird hierbei meist angenommen, dass das im Studienverlauf erworbene Professionswissen eine wesentliche Grundlage für den Aufbau von Fähigkeiten zur Unterrichtsplanung bildet.
Lerngelegenheiten zur Anwendung dieses Professionswissens bieten vor allem schulpraktische Phasen im fortgeschrittenen Studienverlauf. Es wird aber ebenso angenommen, dass gerade Erfahrungen mit der Unterrichtsplanung den Aufbau von Professionswissen unterstützen.
Der Zusammenhang zwischen dem Ausmaß des Professionswissens und der Entwicklung von Planungsfähigkeit ist bisher unzureichend empirisch geklärt. Eine besondere methodische Herausforderung besteht darin, Planungsfähigkeiten sowohl möglichst authentisch als auch auf standardisierte Weise zu erfassen. Zur Untersuchung des genannten Zusammenhangs wurde eine längsschnittliche Studie im Prä-Post-Design bei angehenden Physiklehrkräften (N = 68 im Längsschnitt) an vier Universitäten durchgeführt.
Die Unterrichtsplanungsfähigkeit wurde mit Hilfe eines standardisierten Performanztests vor und nach dem Absolvieren eines Praxissemesters erfasst, indem als Standardsituation der Entwurf einer Unterrichtsstunde zum 3. Newton’schen Axiom unter definierten Zeitvorgaben im Praxissemester simuliert wurde. Zusätzlich wurden das fachliche, fachdidaktische und pädagogische Wissen der Studierenden mit Hilfe standardisierter Instrumente zu beiden Zeitpunkten erhoben, sowie die einschlägigen Lerngelegenheiten im Praxissemester über einen Fragebogen erfasst.
Sowohl für Unterrichtsplanungsfähigkeit als auch für alle Wissensvariablen können Zuwächse im Praxissemester beobachtet werden. Cross-Lagged-Panel-Analysen zeigen, dass insbesondere die Ausprägung des fachdidaktischen und pädagogischen Wissens der Studierenden am Beginn des Praxissemesters die Entwicklung von Unterrichtsplanungsfähigkeit begünstigt.
Toll-like receptor (TLR) can trigger an immune response against virus including SARS-CoV-2. TLR expression/distribution is varying in mesenchymal stromal cells (MSCs) depending on their culture environments. Here, to explore the effect of periodic thermomechanical cues on TLRs, thermally controlled shape-memory polymer sheets with programmable actuation capacity were created. The proportion of MSCs expressing SARS-CoV-2-associated TLRs was increased upon stimulation. The TLR4/7 colocalization was promoted and retained in the endoplasmic reticula. The TLR redistribution was driven by myosin-mediated F-actin assembly. These results highlight the potential of boosting the immunity for combating COVID-19 via thermomechanical preconditioning of MSCs.
3A 1954+319 has been classified for a long time as a symbiotic X-ray binary, hosting a slowly rotating neutron star and an aged M red giant. Recently, this classification has been revised thanks to the discovery that the donor star is an M supergiant. This makes 3A 1954+319 a rare type of high-mass X-ray binary consisting of a neutron star and a red supergiant donor. In this paper, we analyse two archival and still unpublished XMM-Newton and NuSTAR observations of the source. We perform a detailed hardness ratio-resolved spectral analysis to search for spectral variability that could help investigating the structures of the inhomogeneous M supergiant wind from which the neutron star is accreting. We discuss our results in the context of wind-fed supergiant X-ray binaries and show that the newest findings on 3A 1954+319 reinforce the hypothesis that the neutron star in this system is endowed with a magnetar-like magnetic field strength (greater than or similar to 10(14) G).
Mindful eating
(2024)
Maladaptive eating behaviors such as emotional eating, external eating, and loss-of-control eating are widespread in the general population. Moreover, they are associated to adverse health outcomes and well-known for their role in the development and maintenance of eating disorders and obesity (i.e., eating and weight disorders). Eating and weight disorders are associated with crucial burden for individuals as well as high costs for society in general. At the same time, corresponding treatments yield poor outcomes. Thus, innovative concepts are needed to improve prevention and treatment of these conditions.
The Buddhist concept of mindfulness (i.e., paying attention to the present moment without judgement) and its delivery via mindfulness-based intervention programs (MBPs) has gained wide popularity in the area of maladaptive eating behaviors and associated eating and weight disorders over the last two decades. Though previous findings on their effects seem promising, the current assessment of mindfulness and its mere application via multi-component MBPs hampers to draw conclusions on the extent to which mindfulness-immanent qualities actually account for the effects (e.g., the modification of maladaptive eating behaviors). However, this knowledge is pivotal for interpreting previous effects correctly and for avoiding to cause harm in particularly vulnerable groups such as those with eating and weight disorders.
To address these shortcomings, recent research has focused on the context-specific approach of mindful eating (ME) to investigate underlying mechanisms of action. ME can be considered a subdomain of generic mindfulness describing it specifically in relation to the process of eating and associated feelings, thoughts, and motives, thus including a variety of different attitudes and behaviors. However, there is no universal operationalization and the current assessment of ME suffers from different limitations. Specifically, current measurement instruments are not suited for a comprehensive assessment of the multiple facets of the construct that are currently discussed as important in the literature. This in turn hampers comparisons of different ME facets which would allow to evaluate their particular effect on maladaptive eating behaviors. This knowledge is needed to tailor prevention and treatment of associated eating and weight disorders properly and to explore potential underlying mechanisms of action which have so far been proposed mainly on theoretical grounds.
The dissertation at hand aims to provide evidence-based fundamental research that contributes to our understanding of how mindfulness, more specifically its context-specific form of ME, impacts maladaptive eating behaviors and, consequently, how it could be used appropriately to enrich the current prevention and treatment approaches for eating and weight disorders in the future.
Specifically, in this thesis, three scientific manuscripts applying several qualitative and quantitative techniques in four sequential studies are presented. These manuscripts were published in or submitted to three scientific peer-reviewed journals to shed light on the following questions:
I. How can ME be measured comprehensively and in a reliable and valid way to advance the understanding of how mindfulness works in the context of eating?
II. Does the context-specific construct of ME have an advantage over the generic concept in advancing the understanding of how mindfulness is related to maladaptive eating behaviors?
III. Which ME facets are particularly useful in explaining maladaptive eating behaviors?
IV. Does training a particular ME facet result in changes in maladaptive eating behaviors?
To answer the first research question (Paper 1), a multi-method approach using three subsequent studies was applied to develop and validate a comprehensive self-report instrument to assess the multidimensional construct of ME - the Mindful Eating Inventory (MEI). Study 1 aimed to create an initial version of the MEI by following a three-step approach: First, a comprehensive item pool was compiled by including selected and adapted items of the existing ME questionnaires and supplementing them with items derived from an extensive literature review. Second, the preliminary item pool was complemented and checked for content validity by experts in the field of eating behavior and/or mindfulness (N = 15). Third, the item pool was further refined through qualitative methods: Three focus groups comprising laypersons (N = 16) were used as a check for applicability. Subsequently, think-aloud protocols (N = 10) served as a last check of comprehensibility and elimination of ambiguities.
The resulting initial MEI version was tested in Study 2 in an online convenience sample (N = 828) to explore its factor structure using exploratory factor analysis (EFA). Results were used to shorten the questionnaire in accordance with qualitative and quantitative criteria yielding the final MEI version which encompasses 30 items. These items were assigned to seven ME facets: (1) ‘Accepting and Non-attached Attitude towards one’s own eating experience’ (ANA), (2) ‘Awareness of Senses while Eating’ (ASE), (3) ‘Eating in Response to awareness of Fullness‘ (ERF), (4) ‘Awareness of eating Triggers and Motives’ (ATM), (5) ‘Interconnectedness’ (CON), (6) ‘Non-Reactive Stance’ (NRS) and (7) Focused Attention on Eating’ (FAE).
Study 3 sought to confirm the found facets and the corresponding factor structure in an independent online convenience sample (N = 612) using confirmatory factor analysis (CFA). The study served as further indication of the assumed multidimensionality of ME (the correlational seven-factor model was shown to be superior to a single-factor model). Psychometric properties of the MEI, regarding factorial validity, internal consistency, retest-reliability, and observed criterion validity using a wide range of eating-specific and general health-related outcomes, showed the inventory to be suitable for a comprehensive, reliable and valid assessment of ME. These findings were complemented by demonstrating measurement invariance of the MEI regarding gender. In accordance with the factor structure of the MEI, Paper 1 offers an empirically-derived definition of ME, succeeding in overcoming ambiguities and problems of previous attempts at defining the construct.
To answer the second and third research questions (Paper 2) a subsample of Study 2 from the MEI validation studies (N = 292) was analyzed. Incremental validity of ME beyond generic mindfulness was shown using hierarchical regression models concerning the outcome variables of maladaptive eating behaviors (emotional eating and uncontrolled eating) and nutrition behaviors (consumption of energy-dense food). Multiple regression analyses were applied to investigate the impact of the seven different ME facets (identified in Paper 1) on the same outcome variables. The following ME facets significantly contributed to explaining variance in maladaptive eating and nutrition behaviors: Accepting and Non-attached Attitude towards one`s own eating experience (ANA), Eating in Response to awareness of Fullness (ERF), the Awareness of eating Triggers and Motives (ATM), and a Non-Reactive Stance (NRS, i.e., an observing, non-impulsive attitude towards eating triggers). Results suggest that these ME facets are promising variables to consider when a) investigating potential underlying mechanisms of mindfulness and MBPs in the context of eating and b) addressing maladaptive eating behaviors in general as well as in the prevention and treatment of eating and weight disorders.
To answer the fourth research question (Paper 3), a training on an isolated exercise (‘9 Hunger’) based on the previously identified ME facet ATM was designed to explore its particular association with changes in maladaptive eating behaviors and thus to preliminary explore one possible mechanism of action. The online study was realized using a randomized controlled trial (RCT) design. Latent Change Scores (LCS) across three measurement points (before the training, directly after the training and three months later) were compared between the intervention group (n = 211) and a waitlist control group (n = 188). Short- and longer-term effects of the training could be shown on maladaptive eating behaviors (emotional eating, external eating, loss-of-control eating) and associated outcomes (intuitive eating, ME, self-compassion, well-being). Findings serve as preliminary empirical evidence that MBPs might influence maladaptive eating behaviors through an enhanced non-judgmental awareness of and distinguishment between eating motives and triggers (i.e., ATM). This mechanism of action had previously only been hypothesized from a theoretical perspective. Since maladaptive eating behaviors are associated with eating and weight disorders, the findings can enhance our understanding of the general effects of MBPs on these conditions.
The integration of the different findings leads to several suggestions of how ME might enrich different kinds of future interventions on maladaptive eating behaviors to improve health in general or the prevention and treatment of eating and weight disorders in particular. Strengths of the thesis (e.g., deliberate specific methodology, variety of designs and methods, high number of participants) are emphasized. The main limitations particularly regarding sample characteristics (e.g., higher level of formal education, fewer males, self-selected) are discussed to arrive at an outline for future studies (e.g., including multi-modal-multi-method approaches, clinical eating disorder samples and youth samples) to improve upcoming research on ME and underlying mechanisms of action of MBPs for maladaptive eating behaviors and associated eating and weight disorders.
This thesis enriches current research on mindfulness in the context of eating by providing fundamental research on the core of the ME construct. Thereby it delivers a reliable and valid instrument to comprehensively assess ME in future studies as well as an operational definition of the construct. Findings on ME facet level might inform upcoming research and practice on how to address maladaptive eating behaviors appropriately in interventions. The ME skill ‘Awareness of eating Triggers and Motives (ATM)’ as one particular mechanism of action should be further investigated in representative community and specific clinical samples to examine the validity of the results in these groups and to justify an application of the concept to the general population as well as to subgroups with eating and weight disorders in particular.
In conclusion, findings of the current thesis can be used to set future research on mindfulness, more specifically ME, and its underlying mechanism in the context of eating on a more evidence-based footing. This knowledge can inform upcoming prevention and treatment to tailor MBPs on maladaptive eating behaviors and associated eating and weight disorders appropriately.
Heat stress (HS) is a major abiotic stress that negatively affects plant growth and productivity. However, plants have developed various adaptive mechanisms to cope with HS, including the acquisition and maintenance of thermotolerance, which allows them to respond more effectively to subsequent stress episodes. HS memory includes type II transcriptional memory which is characterized by enhanced re-induction of a subset of HS memory genes upon recurrent HS. In this study, new regulators of HS memory in A. thaliana were identified through the characterization of rein mutants.
The rein1 mutant carries a premature stop in CYCLIN-DEPENDENT-KINASE 8 (CDK8) which is part of the cyclin kinase module of the Mediator complex. Rein1 seedlings show impaired type II transcriptional memory in multiple heat-responsive genes upon re-exposure to HS. Additionally, the mutants exhibit a significant deficiency in HS memory at the physiological level. Interaction studies conducted in this work indicate that CDK8 associates with the memory HEAT SHOCK FACTORs HSAF2 and HSFA3. The results suggest that CDK8 plays a crucial role in HS memory in plants together with other memory HSFs, which may be potential targets of the CDK8 kinase function. Understanding the role and interaction network of the Mediator complex during HS-induced transcriptional memory will be an exciting aspect of future HS memory research.
The second characterized mutant, rein2, was selected based on its strongly impaired pAPX2::LUC re-induction phenotype. In gene expression analysis, the mutant revealed additional defects in the initial induction of HS memory genes. Along with this observation, basal thermotolerance was impaired similarly as HS memory at the physiological level in rein2. Sequencing of backcrossed bulk segregants with subsequent fine mapping narrowed the location of REIN2 to a 1 Mb region on chromosome 1. This interval contains the At1g65440 gene, which encodes the histone chaperone SPT6L. SPT6L interacts with chromatin remodelers and bridges them to the transcription machinery to regulate nucleosome and Pol II occupancy around the transcriptional start site. The EMS-induced missense mutation in SPT6L may cause altered HS-induced gene expression in rein2, possibly triggered by changes in the chromatin environment resulting from altered histone chaperone function.
Expanding research on screen-derived factors that modify type II transcriptional memory has the potential to enhance our understanding of HS memory in plants. Discovering connections between previously identified memory factors will help to elucidate the underlying network of HS memory. This knowledge can initiate new approaches to improve heat resilience in crops.
Schlussfolgerungen
(2023)
Erwartungsgemäß spielen die Traditionen der nationalstaatlichen Migrationspolitik weiterhin eine sehr wichtige Rolle, die Pfadabhängigkeit in diesem Politikfeld bleibt hoch. Die Verteilung der Zuständigkeiten in der Migrationspolitik und der Integration von Migranten in den Nationalstaaten ist nach wie vor sehr unterschiedlich. Bei der Umsetzung von Integrationsstrategien an der Basis sollte die jeweilige Politik auf das Profil sowohl der lokalen Migrantengemeinschaft als auch der einheimischen Bevölkerung zugeschnitten sein. Daneben sind ein besseres Migrationsmanagement in der lokalen Verwaltung und das Zusammenspiel von Top-down- und Bottom-up-Bemühungen zur Integration von Migranten von Bedeutung.
Integration von Zuwanderern
(2023)
Dieses Kapitel befasst sich mit der Beziehung zwischen der öffentlichen Meinung zur Migration und der Medienberichterstattung darüber. Verschiedene Erklärungsmodelle, darunter individuelle Merkmale, kulturelle Faktoren und der Einfluss von Medien und Politik, wurden vorgeschlagen, um die Einstellung der Öffentlichkeit gegenüber Migranten zu erklären. Es ist wichtig, den lokalen Kontext zu verstehen, da der Anteil der in den einzelnen Regionen und Städten lebenden Migranten sehr unterschiedlich ist. Die Bereitstellung korrekter statistischer Informationen, die Hervorhebung der Vielfalt der aktuellen Migrationsmuster in Europa und die Teilnahme an Medien- und öffentlichen Diskussionen sind Möglichkeiten, um die öffentliche Meinung auf lokaler Ebene zu beeinflussen.
In diesem einleitenden Kapitel beschreiben die Herausgeber die wichtigsten theoretischen Grundlagen der Analyse dieses Buches und den methodischen Ansatz. Der Kern des Buches besteht aus 14 länderspezifischen Kapiteln, die einen europäischen Vergleich ermöglichen und die zunehmende Varianz der migrationspolitischen Ansätze innerhalb und zwischen den europäischen Ländern aufzeigen. Der Grad der lokalen Autonomie, der Grad der Zentralisierung und die traditionellen Formen der Migrationspolitik sind Faktoren, die insbesondere die Möglichkeiten der lokalen Behörden beeinflussen, ihre eigene Integrationspolitik zu formulieren.
Aims:
Although risk scores to predict type 2 diabetes exist, cost-effectiveness of risk thresholds to target prevention interventions are unknown. We applied cost-effectiveness analysis to identify optimal thresholds of predicted risk to target a low-cost community-based intervention in the USA.
Methods:
We used a validated Markov-based type 2 diabetes simulation model to evaluate the lifetime cost-effectiveness of alternative thresholds of diabetes risk. Population characteristics for the model were obtained from NHANES 2001-2004 and incidence rates and performance of two noninvasive diabetes risk scores (German diabetes risk score, GDRS, and ARIC 2009 score) were determined in the ARIC and Cardiovascular Health Study (CHS). Incremental cost-effectiveness ratios (ICERs) were calculated for increasing risk score thresholds. Two scenarios were assumed: 1-stage (risk score only) and 2-stage (risk score plus fasting plasma glucose (FPG) test (threshold 100 mg/dl) in the high-risk group).
Results:
In ARIC and CHS combined, the area under the receiver operating characteristic curve for the GDRS and the ARIC 2009 score were 0.691 (0.677-0.704) and 0.720 (0.707-0.732), respectively. The optimal threshold of predicted diabetes risk (ICER < $50,000/QALY gained in case of intervention in those above the threshold) was 7% for the GDRS and 9% for the ARIC 2009 score. In the 2-stage scenario, ICERs for all cutoffs >= 5% were below $50,000/QALY gained.
Conclusions:
Intervening in those with >= 7% diabetes risk based on the GDRS or >= 9% on the ARIC 2009 score would be cost-effective. A risk score threshold >= 5% together with elevated FPG would also allow targeting interventions cost-effectively.
This paper is focused on the temperature-dependent synthesis of gold nanotriangles in a vesicular template phase, containing phosphatidylcholine and AOT, by adding the strongly alternating polyampholyte PalPhBisCarb.
UV-vis absorption spectra in combination with TEM micrographs show that flat gold nanoplatelets are formed predominantly in the presence of the polyampholyte at 45°C. The formation of triangular and hexagonal nanoplatelets can be directly influenced by the kinetic approach, i.e., by varying the polyampholyte dosage rate at 45°C. Corresponding zeta potential measurements indicate that a temperature-dependent adsorption of the polyampholyte on the {111} faces will induce the symmetry breaking effect, which is responsible for the kinetically controlled hindered vertical and preferred lateral growth of the nanoplatelets.
Deutschland
(2023)
Das Kapitel beginnt mit einem kurzen historischen Überblick über den Übergang Deutschlands im 20. und 21. Jahrhundert von einem Transit- und Auswanderungsland zu einem Einwanderungsland. Der nächste Teil des Kapitels befasst sich mit den Herausforderungen und Problemen der deutschen Einwanderungspolitik in einem föderalen Mehrebenensystem. Abschließend analysiert das Kapitel einige Trends in der deutschen Migrationspolitik seit der Flüchtlingskrise 2015, wie etwa Veränderungen im Parteiensystem und in den Konzepten, die der Migrationspolitik zugrunde liegen, um die Zuwanderung nach Deutschland besser zu steuern, zu kontrollieren und zu begrenzen.
Does working in a gender-atypical occupation reduce individuals’ likelihood of finding a different-sex romantic partner, and do such occupational partnership penalties contribute to occupational gender segregation? To answer this question, we theorized partnership penalties for working in gender-atypical occupations by drawing on insights from evolutionary psychology, social constructivism, and rational choice theory and exploited the stability of occupational pathways in Germany. In Study 1, we analyzed observational data from a national probability sample (N= 1,634,944) to assess whether individuals in gender-atypical occupations were less likely to be partnered than individuals who worked in gender typical occupations. To assess whether the observed partnership gaps found in Study 1 were causally related to the gender typicality of men’s and women’s occupations, we conducted a field experiment on a dating app (N = 6,778). Because the findings from Study 2 suggested that young women and men indeed experienced penalties for working in a gender-atypical occupation (at least when they were not highly attractive), we employed a choice-experimental design in Study 3 (N = 1,250) to assess whether women and men were aware of occupational partnership penalties and showed that anticipating occupational partnership penalties may keep young and highly educated women from working in gender-atypical occupations. Our main conclusion therefore is that that observed penalties and their anticipation seem to be driven by unconscious rather than conscious processes.
Dieses Buch gibt einen Überblick über die europäische Migrationspolitik und die verschiedenen institutionellen Arrangements innerhalb und zwischen verschiedenen Akteuren wie Kommunalverwaltungen, lokalen Medien, lokaler Wirtschaft und lokalen zivilgesellschaftlichen Initiativen. Sowohl die Rolle der lokalen Behörden in diesem Politikfeld als auch ihre Zusammenarbeit mit zivilgesellschaftlichen Initiativen oder Netzwerken sind noch zu wenig erforschte Themen der Forschung. Als Antwort darauf bietet dieses Buch eine Reihe von detaillierten Fallstudien, die sich auf die sechs Hauptgruppen nationaler und administrativer Traditionen in Europa konzentrieren: Germanische, skandinavische, napoleonische, südosteuropäische, mittelosteuropäische und angelsächsische.
In this study, 3-D models of P-wave velocity (Vp) and P-wave and S-wave ratio (Vp/Vs) of the crust and upper mantle in the Eastern and eastern Southern Alps (northern Italy and southern Austria) were calculated using local earthquake tomography (LET). The data set includes high-quality arrival times from well-constrained hypocenters observed by the dense, temporary seismic networks of the AlpArray AASN and SWATH-D. The resolution of the LET was checked by synthetic tests and analysis of the model resolution matrix. The small inter-station spacing (average of similar to 15 km within the SWATH-D network) allowed us to image crustal structure at unprecedented resolution across a key part of the Alps. The derived P velocity model revealed a highly heterogeneous crustal structure in the target area. One of the main findings is that the lower crust is thickened, forming a bulge at 30-50 km depth just south of and beneath the Periadriatic Fault and the Tauern Window. This indicates that the lower crust decoupled both from its mantle substratum as well as from its upper crust. The Moho, taken to be the iso-velocity contour of Vp = 7.25 km/s, agrees with the Moho depth from previous studies in the European and Adriatic forelands. It is shallower on the Adriatic side than on the European side. This is interpreted to indicate that the European Plate is subducted beneath the Adriatic Plate in the Eastern and eastern Southern Alps.
Marine macroalgae are a key primary producer in coastal ecosystems, but are often overlooked in blue carbon inventories. Large quantities of macroalgal detritus deposit on beaches, but the fate of wrack carbon (C) is little understood. If most of the wrack carbon is respired back to CO2, there would be no net carbon sequestration. However, if most of the wrack carbon is converted to bicarbonate (alkalinity) or refractory DOC, wrack deposition would represent net carbon sequestration if at least part of the metabolic products (e.g., reduced Fe and S) are permanently removed (i.e., long-term burial) and the DOC is not remineralised. To investigate the release of macroalgal C via porewater and its potential to contribute to C sequestration (blue carbon), we monitored the degradation of Ecklonia radiata in flow-through mesocosms simulating tidal flushing on sandy beaches. Over 60 days, 81% of added E. radiata organic matter (OM) decomposed. Per 1 mol of detritus C, the degradation produced 0.48 +/- 0.34 mol C of dissolved organic carbon (DOC) (59%) and 0.25 +/- 0.07 mol C of dissolved inorganic carbon (DIC) (31%) in porewater, and a small amount of CO2 (0.3 +/- 0.0 mol C; ca. 3%) which was emitted to the atmosphere. A significant amount of carbonate alkalinity was found in porewater, equating to 33% (0.27 +/- 0.05 mol C) of the total degraded C. The degradation occurred in two phases. In the first phase (days 0-3), 27% of the OM degraded, releasing highly reactive DOC. In the second phase (days 4-60), the labile DOC was converted to DIC. The mechanisms underlying E. radiata degradation were sulphate reduction and ammonification. It is likely that the carbonate alkalinity was primarily produced through sulphate reduction. The formation of carbonate alkalinity and semi-labile or refractory DOC from beach wrack has the potential to play an overlooked role in coastal carbon cycling and contribute to marine carbon sequestration.
About 15 years ago, the first Massive Open Online Courses (MOOCs) appeared and revolutionized online education with more interactive and engaging course designs. Yet, keeping learners motivated and ensuring high satisfaction is one of the challenges today's course designers face. Therefore, many MOOC providers employed gamification elements that only boost extrinsic motivation briefly and are limited to platform support. In this article, we introduce and evaluate a gameful learning design we used in several iterations on computer science education courses. For each of the courses on the fundamentals of the Java programming language, we developed a self-contained, continuous story that accompanies learners through their learning journey and helps visualize key concepts. Furthermore, we share our approach to creating the surrounding story in our MOOCs and provide a guideline for educators to develop their own stories. Our data and the long-term evaluation spanning over four Java courses between 2017 and 2021 indicates the openness of learners toward storified programming courses in general and highlights those elements that had the highest impact. While only a few learners did not like the story at all, most learners consumed the additional story elements we provided. However, learners' interest in influencing the story through majority voting was negligible and did not show a considerable positive impact, so we continued with a fixed story instead. We did not find evidence that learners just participated in the narrative because they worked on all materials. Instead, for 10-16% of learners, the story was their main course motivation. We also investigated differences in the presentation format and concluded that several longer audio-book style videos were most preferred by learners in comparison to animated videos or different textual formats. Surprisingly, the availability of a coherent story embedding examples and providing a context for the practical programming exercises also led to a slightly higher ranking in the perceived quality of the learning material (by 4%). With our research in the context of storified MOOCs, we advance gameful learning designs, foster learner engagement and satisfaction in online courses, and help educators ease knowledge transfer for their learners.
Confronted with a new wave of criticism on the in effectiveness of its development programs, the World Bank embarked on a revitalization process, turning to private investors to finance International Development Association projects and widening its mandate. To explain these adaptation strategies of the World Bank to regain relevance, this piece draws on organizational ecology and orchestration scholarship. We contend that international organizations rely on two adaptation mechanisms, orchestration and scope expansion, when they lose their role as focal actors in an issue area. We find that the World Bank has indeed lost market share and has relied on these two mechanisms to revitalize itself. We show that the World Bank responded to changes in the environment by orchestrating a private sector-oriented capital increase, prioritizing private funding for development through a “cascade approach,” and expanding the scope of its mandate into adjacent domains of transnational governance, including climate change and global health.
Judging the animacy of words
(2017)
The age at which members of a semantic category are learned (age of acquisition), the typicality they demonstrate within their corresponding category, and the semantic domain to which they belong (living, non-living) are known to influence the speed and accuracy of lexical/semantic processing. So far, only a few studies have looked at the origin of age of acquisition and its interdependence with typicality and semantic domain within the same experimental design. Twenty adult participants performed an animacy decision task in which nouns were classified according to their semantic domain as being living or non-living. Response times were influenced by the independent main effects of each parameter: typicality, age of acquisition, semantic domain, and frequency. However, there were no interactions. The results are discussed with respect to recent models concerning the origin of age of acquisition effects.
Citizenship
(2024)
Greening global governance
(2022)
The last decades have seen a remarkable expansion in the number of International Organizations (IOs) that have mainstreamed environmental issues into their policy scope—in many cases due to the pressure of civil society. We hypothesize that International Non-Governmental Organizations (INGOs), whose headquarters are in proximity to the headquarters of IOs, are more likely to affect IOs' expansion into the environmental domain. We test this explanation by utilizing a novel dataset on the strength of environmental global civil society in proximity to the headquarters of 76 IOs between 1950 and 2017. Three findings stand out. First, the more environmental INGOs have their secretariat in proximity to the headquarter of an IO, the more likely the IO mainstreams environmental policy. Second, proximate INGOs’ contribution increases when they can rely on domestically focused NGOs in member states. Third, a pathway case reveals that proximate INGOs played an essential role in inside lobbying, outside lobbying and information provision during the campaign to mainstream environmental issues at the World Bank. However, their efforts relied to a substantial extent on the work of local NGOs on the ground.
Modern data analysis tasks often involve control flow statements, such as the iterations in PageRank and K-means. To achieve scalability, developers usually implement these tasks in distributed dataflow systems, such as Spark and Flink. Designers of such systems have to choose between providing imperative or functional control flow constructs to users. Imperative constructs are easier to use, but functional constructs are easier to compile to an efficient dataflow job. We propose Mitos, a system where control flow is both easy to use and efficient. Mitos relies on an intermediate representation based on the static single assignment form. This allows us to abstract away from specific control flow constructs and treat any imperative control flow uniformly both when building the dataflow job and when coordinating the distributed execution.
Editorial
(2023)
The combined effect of ultraviolet (UV) light soaking and self-assembled monolayer deposition on the work function (WF) of thin ZnO layers and on the efficiency of hole injection into the prototypical conjugated polymer poly(3-hexylthiophen-2,5-diyl) (P3HT) is systematically investigated. It is shown that the WF and injection efficiency depend strongly on the history of UV light exposure. Proper treatment of the ZnO layer enables ohmic hole injection into P3HT, demonstrating ZnO as a potential anode material for organic optoelectronic devices. The results also suggest that valid conclusions on the energy-level alignment at the ZnO/organic interfaces may only be drawn if the illumination history is precisely known and controlled. This is inherently problematic when comparing electronic data from ultraviolet photoelectron spectroscopy (UPS) measurements carried out under different or ill-defined illumination conditions.
Phytoliths in particulate matter released by wind erosion on arable land in La Pampa, Argentina
(2022)
Silicon (Si) is considered a beneficial element in plant nutrition, but its importance on ecosystems goes far beyond that. Various forms of silicon are found in soils, of which the phytogenic pool plays a decisive role due to its good availability. This Si returns to the soil through the decomposition of plant residues, where they then participate in the further cycle as biogenic amorphous silica (bASi) or so-called phytoliths. These have a high affinity for water, so that the water holding capacity and water availability of soils can be increased even by small amounts of ASi. Agricultural land is a considerable global dust source, and dust samples from arable land have shown in cloud formation experiments a several times higher ice nucleation activity than pure mineral dust. Here, particle sizes in the particulate matter fractions (PM) are important, which can travel long distances and reach high altitudes in the atmosphere. Based on this, the research question was whether phytoliths could be detected in PM samples from wind erosion events, what are the main particle sizes of phytoliths and whether an initial quantification was possible.Measurements of PM concentrations were carried out at a wind erosion measuring field in the province La Pampa, Argentina. PM were sampled during five erosion events with Environmental Dust Monitors (EDM). After counting and classifying all particles with diameters between 0.3 and 32 mu m in the EDMs, they are collected on filters. The filters were analyzed by Scanning Electron Microscopy and Energy Dispersive X-Ray analysis (SEM-EDX) to investigate single or ensembles of particles regarding composition and possible origins.The analyses showed up to 8.3 per cent being phytoliths in the emitted dust and up to 25 per cent of organic origin. Particles of organic origin are mostly in the coarse dust fraction, whereas phytoliths are predominately transported in the finer dust fractions. Since phytoliths are both an important source of Si as a plant nutrient and are also involved in soil C fixation, their losses from arable land via dust emissions should be considered and its specific influence on atmospheric processes should be studied in detail in the future.
Background:
Anti-TNFα monoclonal antibodies (mAbs) are a well-established treatment for patients with Crohn’s disease (CD). However, subtherapeutic concentrations of mAbs have been related to a loss of response during the first year of therapy1. Therefore, an appropriate dosing strategy is crucial to prevent the underexposure of mAbs for those patients. The aim of our study was to assess the impact of different dosing strategies (fixed dose or body size descriptor adapted) on drug exposure and the target concentration attainment for two different anti-TNFα mAbs: infliximab (IFX, body weight (BW)-based dosing) and certolizumab pegol (CZP, fixed dosing). For this purpose, a comprehensive pharmacokinetic (PK) simulation study was performed.
Methods:
A virtual population of 1000 clinically representative CD patients was generated based on the distribution of CD patient characteristics from an in-house clinical database (n = 116). Seven dosing regimens were investigated: fixed dose and per BW, lean BW (LBW), body surface area, height, body mass index and fat-free mass. The individual body size-adjusted doses were calculated from patient generated body size descriptor values. Then, using published PK models for IFX and CZP in CD patients2,3, for each patient, 1000 concentration–time profiles were simulated to consider the typical profile of a specific patient as well as the range of possible individual profiles due to unexplained PK variability across patients. For each dosing strategy, the variability in maximum and minimum mAb concentrations (Cmax and Cmin, respectively), area under the concentration-time curve (AUC) and the per cent of patients reaching target concentration were assessed during maintenance therapy.
Results:
For IFX and CZP, Cmin showed the highest variability between patients (CV ≈110% and CV ≈80%, respectively) with a similar extent across all dosing strategies. For IFX, the per cent of patients reaching the target (Cmin = 5 µg/ml) was similar across all dosing strategies (~15%). For CZP, the per cent of patients reaching the target average concentration of 17 µg/ml ranged substantially (52–71%), being the highest for LBW-adjusted dosing.
Conclusion:
By using a PK simulation approach, different dosing regimen of IFX and CZP revealed the highest variability for Cmin, the most commonly used PK parameter guiding treatment decisions, independent upon dosing regimen. Our results demonstrate similar target attainment with fixed dosing of IFX compared with currently recommended BW-based dosing. For CZP, the current fixed dosing strategy leads to comparable percentage of patients reaching target as the best performing body size-adjusted dosing (66% vs. 71%, respectively).
Sanctions are critical to the Security Council's efforts to fight terrorism. What is striking is that the Council's sanctions regimes are subject to detailed sets of rules and decision criteria. The scholarship on human rights in counterterrorism assumes that rights advocacy and court litigation have prompted this development. The article complements this literature by highlighting an unexplored internal driver of legal-regulatory decision-making and explores how mixed-motive interest constellations among Security Council members have affected the extent of committee regulations and the content of decisions taken by sanctions committees. Based on internal documents and diplomatic cables, a comparative analysis of the Iraq sanctions regime and the counterterrorism sanctions regime demonstrates that mixed-motive interest constellations among Security Council members provide incentives to elaborate rules to guide decision-making resulting in legal-regulatory sanctions governance, even if the human rights of targeted individuals are not at stake. For comparative leverage and to assess the limits of the proposed mechanism, the analysis is briefly extended to other sanctions regimes targeting individuals (Democratic Republic of the Congo and Sudan). The findings have implications for this essential tool of the Security Council to react to threats to peace as diverse as counterterrorism, nonproliferation, and internal armed conflict.
The article explores whether and to what extent expert recommendations affect decision-making within the Security Council and its North Korea and Iran sanctions regimes. The article first develops a rationalist theoretical argument to show why making many second-stage decisions, such as determining lists of items under export restrictions, subjects Security Council members to repeating coordination situations. Expert recommendations may provide focal point solutions to coordination problems, even when interests diverge and preferences remain stable. Empirically, the article first explores whether expert recommendations affected decision-making on commodity sanctions imposed on North Korea. Council members heavily relied on recommended export trigger lists as focal points, solving a divisive conflict among great powers. Second, the article explores whether expert recommendations affected the designation of sanctions violators in the Iran sanctions regime. Council members designated individuals and entities following expert recommendations as focal points, despite conflicting interests among great powers. The article concludes that expert recommendations are an additional means of influence in Security Council decision-making and seem relevant for second-stage decision-making among great powers in other international organisations.
Phase transitions in molecular crystals are often determined by intermolecular interactions. The cage complex of [Co(C12H30N8)](3+) . 3 NO3- is reported to undergo a disorder-order phase transition at T-c1 approximate to 133 K upon cooling. Temperature-dependent neutron and synchrotron diffraction experiments revealed satellite reflections in addition to main reflections in the diffraction patterns below T-c1. The modulation wave vector varies as function of temperature and locks in at T-c3 approximate to 98 K. Here, we demonstrate that the crystal symmetry lowers from hexagonal to monoclinic in the incommensurately modulated phases in T-c1<T<T-c3. Distinctive levels of competitions: trade-off between longer N-H...O and shorter C-H...O hydrogen bonds; steric constraints to dense C-H...O bonds give rise to pronounced modulation of the basic structure. Severely frustrated crystal packing in the incommensurate phase is precursor to optimal balance of intermolecular interactions in the lock-in phase.
Leo Baeck
(2023)
Leo Baeck gilt als bedeutendster Repräsentant des deutschen Judentums in der ersten Hälfte des 20. Jahrhunderts und als Spiritus rector von dessen liberaler Richtung. Er entwickelte seinen Ansatz zu einer jüdischen Theologie in kritischer Auseinandersetzung mit dem zeitgenössischen Protestantismus. Als jüdischer Religionsphilosoph steht Baeck in einer Reihe mit Hermann Cohen (1842–1918), Franz Rosenzweig (1886–1929) und Martin Buber (1878–1965).
Background: The worldwide prevalence of diabetes has been increasing in recent years, with a projected prevalence of 700 million patients by 2045, leading to economic burdens on societies. Type 2 diabetes mellitus (T2DM), representing more than 95% of all diabetes cases, is a multifactorial metabolic disorder characterized by insulin resistance leading to an imbalance between insulin requirements and supply. Overweight and obesity are the main risk factors for developing type 2 diabetes mellitus. The lifestyle modification of following a healthy diet and physical activity are the primary successful treatment and prevention methods for type 2 diabetes mellitus. Problems may exist with patients not achieving recommended levels of physical activity. Electrical muscle stimulation (EMS) is an increasingly popular training method and has become in the focus of research in recent years. It involves the external application of an electric field to muscles, which can lead to muscle contraction. Positive effects of EMS training have been found in healthy individuals as well as in various patient groups. New EMS devices offer a wide range of mobile applications for whole-body electrical muscle stimulation (WB-EMS) training, e.g., the intensification of dynamic low-intensity endurance exercises through WB-EMS. This dissertation project aims to investigate whether WB-EMS is suitable for intensifying low-intensive dynamic exercises such as walking and Nordic walking.
Methods: Two independent studies were conducted. The first study aimed to investigate the reliability of exercise parameters during the 10-meter Incremental Shuttle Walk Test (10MISWT) using superimposed WB-EMS (research question 1, sub-question a) and the difference in exercise intensity compared to conventional walking (CON-W, research question 1, sub-question b). The second study aimed to compare differences in exercise parameters between superimposed WB-EMS (WB-EMS-W) and conventional walking (CON-W), as well as between superimposed WB-EMS (WB-EMS-NW) and conventional Nordic walking (CON-NW) on a treadmill (research question 2). Both studies took place in participant groups of healthy, moderately active men aged 35-70 years. During all measurements, the Easy Motion Skin® WB-EMS low frequency stimulation device with adjustable intensities for eight muscle groups was used. The current intensity was individually adjusted for each participant at each trial to ensure safety, avoiding pain and muscle cramps. In study 1, thirteen individuals were included for each sub question. A randomized cross-over design with three measurement appointments used was to avoid confounding factors such as delayed onset muscle soreness. The 10MISWT was performed until the participants no longer met the criteria of the test and recording five outcome measures: peak oxygen uptake (VO2peak), relative VO2peak (rel.VO2peak), maximum walk distance (MWD), blood lactate concentration, and the rate of perceived exertion (RPE).
Eleven participants were included in study 2. A randomized cross-over design in a study with four measurement appointments was used to avoid confounding factors. A treadmill test protocol at constant velocity (6.5 m/s) was developed to compare exercise intensities. Oxygen uptake (VO2), relative VO2 (rel.VO2) blood lactate, and the RPE were used as outcome variables. Test-retest reliability between measurements was determined using a compilation of absolute and relative measures of reliability. Outcome measures in study 2 were studied using multifactorial analyses of variances.
Results: Reliability analysis showed good reliability for VO2peak, rel.VO2peak, MWD and RPE with no statistically significant difference for WB-EMS-W during 10WISWT. However, differences compared to conventional walking in outcome variables were not found. The analysis of the treadmill tests showed significant effects for the factors CON/WB-EMS and W/NW for the outcome variables VO2, rel.VO2 and lactate, with both factors leading to higher results. However, the difference in VO2 and relative VO2 is within the range of biological variability of ± 12%. The factor combination EMS∗W/NW is statistically non-significant for all three variables. WB-EMS resulted in the higher RPE values, RPE differences for W/NW and EMS∗W/NW were not significant.
Discussion: The present project found good reliability for measuring VO2peak, rel. VO2peak, MWD and RPE during 10MISWT during WB-EMS-W, confirming prior research of the test. The test appears technically limited rather than physiologically in healthy, moderately active men. However, it is unsuitable for investigating differences in exercise intensities using WB-EMS-W compared to CON-W due to different perceptions of current intensity between exercise and rest. A treadmill test with constant walking speed was conducted to adjust individual maximum tolerable current intensity for the second part of the project. The treadmill test showed a significant increase in metabolic demands during WB-EMS-W and WB-EMS-NW by an increased VO2 and blood lactate concentration. However, the clinical relevance of these findings remains debatable. The study also found that WB-EMS superimposed exercises are perceived as more strenuous than conventional exercise. While in parts comparable studies lead to higher results for VO2, our results are in line with those of other studies using the same frequency. Due to the minor clinical relevance the use of WB-EMS as exercise intensification tool during walking and Nordic walking is limited. High device cost should be considered. Habituation to WB-EMS could increase current intensity tolerance and VO2 and make it a meaningful method in the treatment of T2DM. Recent figures show that WB-EMS is used in obese people to achieve health and weight goals. The supposed benefit should be further investigated scientifically.
The termprocess modelis widely used, but rarely agreed upon. This paper proposes a framework for characterizing and building cognitive process models. Process models model not only inputs and outputs but also model the ongoing information transformations at a given level of abstraction. We argue that the following dimensions characterize process models: They have a scope that includes different levels of abstraction. They specify a hypothesized mental information transformation. They make predictions not only for the behavior of interest but also for processes. The models' predictions for the processes can be derived from the input, without reverse inference from the output data. Moreover, the presumed information transformation steps are not contradicting current knowledge of human cognitive capacities. Lastly, process models require a conceptual scope specifying levels of abstraction for the information entering the mind, the proposed mental events, and the behavior of interest. This framework can be used for refining models before testing them or after testing them empirically, and it does not rely on specific modeling paradigms. It can be a guideline for developing cognitive process models. Moreover, the framework can advance currently unresolved debates about which models belong to the category of process models.
In the comment on "Varves of the Dead Sea sedimentary record." Quaternary Science Reviews 215 (Ben Dor et al., 2019): 173-184. by R. Bookman, two recently published papers are suggested to prove that the interpretation of the laminated sedimentary sequence of the Dead Sea, deposited mostly during MIS2 and Holocene pluvials, as annual deposits (i.e., varves) is wrong. In the following response, we delineate several lines of evidence which coalesce to demonstrate that based on the vast majority of evidence, including some of the evidence provided in the comment itself, the interpretation of these sediments as varves is the more likely scientific conclusion. We further discuss the evidence brought up in the comment and its irrelevance and lack of robustness for addressing the question under discussion.
Aldehyde oxidases (AOXs) are a small group of enzymes belonging to the larger family of molybdo-flavoenzymes, along with the well-characterized xanthine oxidoreductase. The two major types of reactions that are catalyzed by AOXs are the hydroxylation of heterocycles and the oxidation of aldehydes to their corresponding carboxylic acids. Different animal species have different complements of AOX genes. The two extremes are represented in humans and rodents; whereas the human genome contains a single active gene (AOX1), those of rodents, such as mice, are endowed with four genes (Aox1-4), clustering on the same chromosome, each encoding a functionally distinct AOX enzyme. It still remains enigmatic why some species have numerous AOX enzymes, whereas others harbor only one functional enzyme. At present, little is known about the physiological relevance of AOX enzymes in humans and their additional forms in other mammals. These enzymes are expressed in the liver and play an important role in the metabolisms of drugs and other xenobiotics. In this review, we discuss the expression, tissue-specific roles, and substrate specificities of the different mammalian AOX enzymes and highlight insights into their physiological roles.
Many prediction tasks can be done based on users’ trace data. This paper explores divergent and convergent thinking as person-related attributes and predicts them based on features gathered in an online course. We use the logfile data of a short Moodle course, combined with an image test (IMT), the Alternate Uses Task (AUT), the Remote Associates Test (RAT), and creative self-efficacy (CSE). Our results show that originality and elaboration metrics can be predicted with an accuracy of ~.7 in cross-validation, whereby predicting fluency and RAT scores perform worst. CSE items can be predicted with an accuracy of ~.45. The best performing model is a Random Forest Tree, where the features were reduced using a Linear Discriminant Analysis in advance. The promising results can help to adjust online courses to the learners’ needs based on their creative performances.
The devil in disguise
(2021)
Envy constitutes a serious issue on Social Networking Sites (SNSs), as this painful emotion can severely diminish individuals' well-being. With prior research mainly focusing on the affective consequences of envy in the SNS context, its behavioral consequences remain puzzling. While negative interactions among SNS users are an alarming issue, it remains unclear to which extent the harmful emotion of malicious envy contributes to these toxic dynamics. This study constitutes a first step in understanding malicious envy’s causal impact on negative interactions within the SNS sphere. Within an online experiment, we experimentally induce malicious envy and measure its immediate impact on users’ negative behavior towards other users. Our findings show that malicious envy seems to be an essential factor fueling negativity among SNS users and further illustrate that this effect is especially pronounced when users are provided an objective factor to mask their envy and justify their norm-violating negative behavior.
The metaverse is envisioned as a virtual shared space facilitated by emerging technologies such as virtual reality (VR), augmented reality (AR), the Internet of Things (IoT), 5G, artificial intelligence (AI), big data, spatial computing, and digital twins (Allam et al., 2022; Dwivedi et al., 2022; Ravenscraft, 2022; Wiles, 2022). While still a nascent concept, the metaverse has the potential to “transform the physical world, as well as transport or extend physical activities to a virtual world” (Wiles, 2022). Big data technologies will also be essential in managing the enormous amounts of data created in the metaverse (Sun et al., 2022). Metaverse technologies can offer the public sector a host of benefits, such as simplified information exchange, stronger communication with citizens, better access to public services, or benefiting from a new virtual economy. Implementations are underway in several cities around the world (Geraghty et al., 2022). In this paper, we analyze metaverse opportunities for the public sector and explore their application in the context of Germany’s Federal Employment Agency. Based on an analysis of academic literature and practical examples, we create a capability map for potential metaverse business capabilities for different areas of the public sector (broadly defined). These include education (virtual training and simulation, digital campuses that offer not just online instruction but a holistic university campus experience, etc.), tourism (virtual travel to remote locations and museums, virtual festival participation, etc.), health (employee training – as for emergency situations, virtual simulations for patient treatment – for example, for depression or anxiety, etc.), military (virtual training to experience operational scenarios without being exposed to a real-world threats, practice strategic decision-making, or gain technical knowledge for operating and repairing equipment, etc.), administrative services (document processing, virtual consultations for citizens, etc.), judiciary (AI decision-making aids, virtual proceedings, etc.), public safety (virtual training for procedural issues, special operations, or unusual situations, etc.), emergency management (training for natural disasters, etc.), and city planning (visualization of future development projects and interactive feedback, traffic management, attraction gamification, etc.), among others. We further identify several metaverse application areas for Germany's Federal Employment Agency. These applications can help it realize the goals of the German government for digital transformation that enables faster, more effective, and innovative government services. They include training of employees, training of customers, and career coaching for customers. These applications can be implemented using interactive learning games with AI agents, virtual representations of the organizational spaces, and avatars interacting with each other in these spaces. Metaverse applications will both use big data (to design the virtual environments) and generate big data (from virtual interactions). Issues related to data availability, quality, storage, processing (and related computing power requirements), interoperability, sharing, privacy and security will need to be addressed in these emerging metaverse applications (Sun et al., 2022). Special attention is needed to understand the potential for power inequities (wealth inequity, algorithmic bias, digital exclusion) due to technologies such as VR (Egliston & Carter, 2021), harmful surveillance practices (Bibri & Allam, 2022), and undesirable user behavior or negative psychological impacts (Dwivedi et al., 2022). The results of this exploratory study can inform public sector organizations of emerging metaverse opportunities and enable them to develop plans for action as more of the metaverse technologies become a reality. While the metaverse body of research is still small and research agendas are only now starting to emerge (Dwivedi et al., 2022), this study offers a building block for future development and analysis of metaverse applications.
Broad and unspecific use of antibiotics accelerates spread of resistances. Sensitive and robust pathogen detection is thus important for a more targeted application. Bacteriophages contain a large repertoire of pathogen-binding proteins. These tailspike proteins (TSP) often bind surface glycans and represent a promising design platform for specific pathogen sensors. We analysed bacteriophage Sf6 TSP that recognizes the O-polysaccharide of dysentery-causing Shigella flexneri to develop variants with increased sensitivity for sensor applications. Ligand polyrhamnose backbone conformations were obtained from 2D H-1,H-1-trNOESY NMR utilizing methine-methine and methine-methyl correlations. They agreed well with conformations obtained from molecular dynamics (MD), validating the method for further predictions. In a set of mutants, MD predicted ligand flexibilities that were in good correlation with binding strength as confirmed on immobilized S. flexneri O-polysaccharide (PS) with surface plasmon resonance. In silico approaches combined with rapid screening on PS surfaces hence provide valuable strategies for TSP-based pathogen sensor design.
Eine veränderte Interozeption ist ein zentrales Korrelat der Anorexia nervosa (AN) und stellt einen potentiellen Ansatz in der Genesung der AN dar. Erste Ergebnisse zur Wirksamkeit von Yoga als körperorientierte Methode in der Therapie der AN sind vielversprechend. Dennoch liegen bislang unzureichende empirische Befunde bezüglich der Frage vor, auf welche Weise Yoga-Strategien und Yoga-Elemente wie Körperhaltungen, Entspannungs-, Atem-, und Meditationsübungen eingesetzt werden sollten. Vor diesem Hintergrund führten wir eine qualitative Pilotstudie mit einer Stichprobe von n=6 Patientinnen mit AN durch, die sich im Anschluss an eine klinische stationäre Behandlung in einer pädagogisch-therapeutischen Facheinrichtung der Jugend- und Eingliederungshilfe (SGB VIII/XII) befanden. Die Studienteilnehmerinnen erhielten eine einstündige Hatha-Yoga-Intervention über mindestens 12 Wochen. Nach der Yoga-Intervention wurden ½- bis 1-stündige halbstrukturierte Leitfadeninterviews zu den Erfahrungen mit den verwendeten Yoga-Strategien durchgeführt. Die Interviews wurden mittels Grounded Theory ausgewertet. Auf der obersten Analyseebene wurden 4 Kategorien differenziert: Angaben 1) zum Beschwerdebild der Studienteilnehmerinnen, 2) zu als hilfreich erlebten Elementen des therapeutischen Rahmens, 3) zu als hilfreich erlebten Yoga-Strategien sowie 4) zu subjektiv wahrgenommenen Konsequenzen der Yoga-Strategien. Bezüglich der als hilfreich erlebten Yoga-Strategien ergaben die Analysen 4 Subkategorien: Merkmale 1) der Bewegungselemente, 2) der Meditations- und Atemübungen, 3) der Entspannungsübungen sowie 4) allgemeine Hinweise zur Durchführung. Die Ergebnisse geben erste Hinweise für die Konzeption von Yoga in der Therapie der AN und zu potentiellen Wirkmechanismen. Weiterführende qualitative sowie quantitative Studien zu u. a. Wirksamkeit, Kontraindikationen oder Mediator- sowie Moderatorvariablen sind erforderlich, um das Potenzial von Yoga in der Therapie der AN noch besser bewerten zu können.
Comprehensive untargeted and targeted analysis of root exudate composition has advanced our understanding of rhizosphere processes. However, little is known about exudate spatial distribution and regulation. We studied the specific metabolite signatures of asparagus root exudates, root outer (epidermis and exodermis), and root inner tissues (cortex and vasculature). The greatest differences were found between exudates and root tissues. In total, 263 non-redundant metabolites were identified as significantly differentially abundant between the three root fractions, with the majority being enriched in the root exudate and/or outer tissue and annotated as 'lipids and lipid-like molecules' or 'phenylpropanoids and polyketides'. Spatial distribution was verified for three selected compounds using MALDI-TOF mass spectrometry imaging. Tissue-specific proteome analysis related root tissue-specific metabolite distributions and rhizodeposition with underlying biosynthetic pathways and transport mechanisms. The proteomes of root outer and inner tissues were spatially very distinct, in agreement with the fundamental differences between their functions and structures. According to KEGG pathway analysis, the outer tissue proteome was characterized by a high abundance of proteins related to 'lipid metabolism', 'biosynthesis of other secondary metabolites' and 'transport and catabolism', reflecting its main functions of providing a hydrophobic barrier, secreting secondary metabolites, and mediating water and nutrient uptake. Proteins more abundant in the inner tissue related to 'transcription', 'translation' and 'folding, sorting and degradation', in accord with the high activity of cortical and vasculature cell layers in growth- and development-related processes. In summary, asparagus root fractions accumulate specific metabolites. This expands our knowledge of tissue-specific plant cell function.
Increasingly fast development cycles and individualized products pose major challenges for today's smart production systems in times of industry 4.0. The systems must be flexible and continuously adapt to changing conditions while still guaranteeing high throughputs and robustness against external disruptions. Deep reinforcement learning (RL) algorithms, which already reached impressive success with Google DeepMind's AlphaGo, are increasingly transferred to production systems to meet related requirements. Unlike supervised and unsupervised machine learning techniques, deep RL algorithms learn based on recently collected sensorand process-data in direct interaction with the environment and are able to perform decisions in real-time. As such, deep RL algorithms seem promising given their potential to provide decision support in complex environments, as production systems, and simultaneously adapt to changing circumstances. While different use-cases for deep RL emerged, a structured overview and integration of findings on their application are missing. To address this gap, this contribution provides a systematic literature review of existing deep RL applications in the field of production planning and control as well as production logistics. From a performance perspective, it became evident that deep RL can beat heuristics significantly in their overall performance and provides superior solutions to various industrial use-cases. Nevertheless, safety and reliability concerns must be overcome before the widespread use of deep RL is possible which presumes more intensive testing of deep RL in real world applications besides the already ongoing intensive simulations.