Fetuin-A and risk of diabetes-related vascular complications
- Background Fetuin-A is a hepatokine which has the capacity to prevent vascular calcification. Moreover, it is linked to the induction of metabolic dysfunction, insulin resistance and associated with increased risk of diabetes. It has not been clarified whether fetuin-A associates with risk of vascular, specifically microvascular, complications in patients with diabetes. We aimed to investigate whether pre-diagnostic plasma fetuin-A is associated with risk of complications once diabetes develops. Methods Participants with incident type 2 diabetes and free of micro- and macrovascular disease from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort (n = 587) were followed for microvascular and macrovascular complications (n = 203 and n = 60, respectively, median follow-up: 13 years). Plasma fetuin-A was measured approximately 4 years prior to diabetes diagnosis. Prospective associations between baseline fetuin-A and risk of complications were assessed with Cox regression. Results InBackground Fetuin-A is a hepatokine which has the capacity to prevent vascular calcification. Moreover, it is linked to the induction of metabolic dysfunction, insulin resistance and associated with increased risk of diabetes. It has not been clarified whether fetuin-A associates with risk of vascular, specifically microvascular, complications in patients with diabetes. We aimed to investigate whether pre-diagnostic plasma fetuin-A is associated with risk of complications once diabetes develops. Methods Participants with incident type 2 diabetes and free of micro- and macrovascular disease from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort (n = 587) were followed for microvascular and macrovascular complications (n = 203 and n = 60, respectively, median follow-up: 13 years). Plasma fetuin-A was measured approximately 4 years prior to diabetes diagnosis. Prospective associations between baseline fetuin-A and risk of complications were assessed with Cox regression. Results In multivariable models, fetuin-A was linearly inversely associated with incident total and microvascular complications, hazard ratio (HR, 95% CI) per standard deviation (SD) increase: 0.86 (0.74; 0.99) for total, 0.84 (0.71; 0.98) for microvascular and 0.92 (0.68; 1.24) for macrovascular complications. After additional adjustment for cardiometabolic plasma biomarkers, including triglycerides and high-density lipoprotein, the associations were slightly attenuated: 0.88 (0.75; 1.02) for total, 0.85 (0.72; 1.01) for microvascular and 0.95 (0.67; 1.34) for macrovascular complications. No interaction by sex could be observed (p > 0.10 for all endpoints). Conclusions Our data show that lower plasma fetuin-A levels measured prior to the diagnosis of diabetes may be etiologically implicated in the development of diabetes-associated microvascular disease.…
Author details: | Anna Birukov, Elli Polemiti, Susanne Jaeger, Norbert Stefan, Matthias Bernd SchulzeORCiDGND |
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DOI: | https://doi.org/10.1186/s12933-021-01439-8 |
ISSN: | 1475-2840 |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/34998417 |
Title of parent work (English): | Cardiovascular diabetology |
Subtitle (English): | a prospective study |
Publisher: | BMC |
Place of publishing: | London |
Publication type: | Article |
Language: | English |
Date of first publication: | 2022/01/08 |
Publication year: | 2022 |
Release date: | 2024/06/03 |
Tag: | Fetuin-A; Type 2 diabetes; biomarkers; epidemiology; microvascular complications; vascular calcification; vascular disease; |
Volume: | 21 |
Issue: | 1 |
Article number: | 6 |
Number of pages: | 11 |
Funding institution: | Projekt DEAL; Federal Ministry of Science, Germany [01 EA 9401];; European Union [SOC 95201408 05F02]; German Cancer Aid [70-2488-Ha I];; European Community [SOC 98200769 05F02]; German Ministry of Education; and Research (BMBF); State of Brandenburg (DZD) [82DZD00302] |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft |
DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
Peer review: | Referiert |
Publishing method: | Open Access / Gold Open-Access |
DOAJ gelistet | |
License (German): | CC-BY - Namensnennung 4.0 International |