- search hit 1 of 1
Increase of urate formation by stimulation of sympathetic hepatic nerves, circulating noradrenaline and glucagon inthe perfused rat liver
- In the isolated rat liver perfused in situ stimulation of the nerve bundles around the portal vein and the hepatic artery caused an increase of urate formation that was inhibited by the α1-blocker prazosine and the xanthine oxidase inhibitor allopurinol. Moreover, nerve stimulation increased glucose and lactate output and decreased perfusion flow. Infusion of noradrenaline had similar effects. Compared to nerve stimulation infusion of glucagon led to a less pronounced increase of urate formation and a twice as large increase in glucose output but a decrease in lactate release without affecting the flow rate. Insulin had no effect on any of the parameters studied.
Author details: | Gerhard Paul PüschelORCiDGND, Annegret Nath, Kurt Jungermann |
---|---|
URN: | urn:nbn:de:kobv:517-opus-16728 |
Publication series (Volume number): | Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe (paper 038) |
Publication type: | Postprint |
Language: | English |
Publication year: | 1987 |
Publishing institution: | Universität Potsdam |
Release date: | 2008/03/14 |
Tag: | Allantoin; Catecholamine; Glucagon; Hepatic nerve; Urate |
Source: | FEBS Letters 219 (1987), 1, p. 145 - 150 , DOI 10.1016/0014-5793(87)81207-3, ISSN 0014-5793 |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft |
Extern / Extern | |
DDC classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
License (German): | Keine öffentliche Lizenz: Unter Urheberrechtsschutz |
External remark: | first published in: FEBS Letters - 219 (1987), 1, p. 145-150 ISSN: 0014-5793 doi: 10.1016/0014-5793(87)81207-3 |