Glucose-responsive shape-memory cryogels
- Boronic ester bonds can be reversibly formed between phenylboronic acid (PBA) and triol moieties. Here, we aim at a glucose-induced shape-memory effect by implementing such bonds as temporary netpoints, which are cleavable by glucose and by minimizing the volume change upon stimulation by a porous cryogel structure. The polymer system consisted of a semi-interpenetrating network (semi-IPN) architecture, in which the triol moieties were part of the permanent network and the PBA moieties were located in the linear polymer diffused into the semi-IPN. In an alkaline medium (pH = 10), the swelling ratio was approximately 35, independent of C-glu varied between 0 and 300 mg/dL. In bending experiments, shape fixity R-f approximate to 80% and shape recovery R-r approximate to 100% from five programming/recovery cycles could be determined. R-r was a function of C-glu in the range from 0 to 300 mg/dL, which accords with the fluctuation range of C-glu in human blood. In this way, the shape-memory hydrogels could play a role in future diabetesBoronic ester bonds can be reversibly formed between phenylboronic acid (PBA) and triol moieties. Here, we aim at a glucose-induced shape-memory effect by implementing such bonds as temporary netpoints, which are cleavable by glucose and by minimizing the volume change upon stimulation by a porous cryogel structure. The polymer system consisted of a semi-interpenetrating network (semi-IPN) architecture, in which the triol moieties were part of the permanent network and the PBA moieties were located in the linear polymer diffused into the semi-IPN. In an alkaline medium (pH = 10), the swelling ratio was approximately 35, independent of C-glu varied between 0 and 300 mg/dL. In bending experiments, shape fixity R-f approximate to 80% and shape recovery R-r approximate to 100% from five programming/recovery cycles could be determined. R-r was a function of C-glu in the range from 0 to 300 mg/dL, which accords with the fluctuation range of C-glu in human blood. In this way, the shape-memory hydrogels could play a role in future diabetes treatment options.…
| Author details: | Marc BehlORCiDGND, Qian Zhao, Andreas LendleinORCiDGND |
|---|---|
| DOI: | https://doi.org/10.1557/jmr.2020.204 |
| ISSN: | 0884-2914 |
| ISSN: | 2044-5326 |
| Title of parent work (English): | Journal of materials research : JMR |
| Publisher: | Springer |
| Place of publishing: | Berlin |
| Publication type: | Article |
| Language: | English |
| Date of first publication: | 2020/10/01 |
| Publication year: | 2020 |
| Release date: | 2023/10/02 |
| Tag: | polymer; porosity; shape memory |
| Volume: | 35 |
| Issue: | 18 |
| Article number: | PII S0884291420002046 |
| Number of pages: | 9 |
| First page: | 2396 |
| Last Page: | 2404 |
| Funding institution: | Helmholtz-Association through programme-oriented fund; Tianjin; University - Helmholtz-Zentrum Geesthacht; Joint Laboratory for; Biomaterials and Regenerative Medicine by the German Federal Ministry of; Education and Research (BMBF) Federal Ministry of Education & Research; (BMBF) [0315496]; Chinese Ministry of Science and Technology; (MOST)Ministry of Science and Technology, China [2008DFA51170] |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
| DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
| Peer review: | Referiert |
