Effect of extracts of poly(ether imide) microparticles on cytotoxicity, ROS generation and proinflammatory effects on human monocytic (THP-1) cells

A high cell viability of around 99 +/- 18% and 99 +/- 5% was observed when THP-1 cells were cultured in the presence of aqueous extracts of the PEI microparticles in medium A and medium B respectively. The obtained microscopic data suggested that PEI particle extracts have no significant effect on cell death, oxidative stress or differentiation to macrophages. It was further found that the investigated proinflammatory markers in THP-1 cells were not up-regulated. These results are promising with regard to the biocompatibility of PEI microparticles and in a next step the hemocompatibility of the microparticles will be examined.

Metadaten
Verfasserangaben:	Reddi K. Kumar, Sayantani Basu, Horst-Dieter Lemke, Joachim Jankowski, Karl Kratz ORCiD, Andreas Lendlein ORCiD GND, Sarada D. Tetali
DOI:	https://doi.org/10.3233/CH-152027
ISSN:	1386-0291
ISSN:	1875-8622
Pubmed ID:	https://pubmed.ncbi.nlm.nih.gov/26639770
Titel des übergeordneten Werks (Englisch):	Clinical hemorheology and microcirculation : blood flow and vessels
Verlag:	IOS Press
Verlagsort:	Amsterdam
Publikationstyp:	Wissenschaftlicher Artikel
Sprache:	Englisch
Jahr der Erstveröffentlichung:	2016
Erscheinungsjahr:	2016
Datum der Freischaltung:	22.03.2020
Freies Schlagwort / Tag:	Chronic kidney disease (CKD); cytotoxicity; human monocytic (THP-1) cells; poly(ether imide) microparticles; reactive oxygen species (ROS)
Band:	61
Seitenanzahl:	14
Erste Seite:	667
Letzte Seite:	680
Fördernde Institution:	Indo-German Science and Technology Centre [IGSTC/NPORE/SDT/2012]; German Federal Ministry for Education and Research (BMBF) [01DQ13006A, 01DQ13006B, 01DQ13006C]; IGSTC funded project [IGSTC/NPORE/SDT/2012]
Organisationseinheiten:	Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Peer Review:	Referiert