Selenoneine ameliorates peroxide-induced oxidative stress in C. elegans
- Scope: Selenoneine (2-selenyl-N-alpha, N-alpha, N-alpha-trimethyl-L-histidine), the selenium (Se) analogue of the ubiquitous thiol compound and putative antioxidant ergothioneine, is the major organic selenium species in several marine fish species. Although its antioxidant efficacy has been proposed, selenoneine has been poorly characterized, preventing conclusions on its possible beneficial health effects. Methods and results: Treatment of Caenorhabditis elegans (C. elegans) with selenoneine for 18 h attenuated the induction of reactive oxygen and nitrogen species (RONS). However, the effect was not immediate, occurring 48 h post-treatment. Total Se and Se speciation analysis revealed that selenoneine was efficiently taken up and present in its original form directly after treatment, with no metabolic transformations observed. 48 h posttreatment, total Se in worms was slightly higher compared to controls and no selenoneine could be detected. Conclusion: The protective effect of selenoneine may not be attributed to the presence ofScope: Selenoneine (2-selenyl-N-alpha, N-alpha, N-alpha-trimethyl-L-histidine), the selenium (Se) analogue of the ubiquitous thiol compound and putative antioxidant ergothioneine, is the major organic selenium species in several marine fish species. Although its antioxidant efficacy has been proposed, selenoneine has been poorly characterized, preventing conclusions on its possible beneficial health effects. Methods and results: Treatment of Caenorhabditis elegans (C. elegans) with selenoneine for 18 h attenuated the induction of reactive oxygen and nitrogen species (RONS). However, the effect was not immediate, occurring 48 h post-treatment. Total Se and Se speciation analysis revealed that selenoneine was efficiently taken up and present in its original form directly after treatment, with no metabolic transformations observed. 48 h posttreatment, total Se in worms was slightly higher compared to controls and no selenoneine could be detected. Conclusion: The protective effect of selenoneine may not be attributed to the presence of the compound itself, but rather to the activation of molecular mechanisms with consequences at more protracted time points.…
Verfasserangaben: | Isabelle RohnORCiDGND, Nina KroepflORCiD, Michael AschnerORCiDGND, Julia BornhorstORCiDGND, Doris KuehneltORCiD, Tanja SchwerdtleORCiDGND |
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DOI: | https://doi.org/10.1016/j.jtemb.2019.05.012 |
ISSN: | 0946-672X |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/31345370 |
Titel des übergeordneten Werks (Englisch): | Journal of trace elements in medicine and biology |
Verlag: | Elsevier GMBH |
Verlagsort: | München |
Publikationstyp: | Wissenschaftlicher Artikel |
Sprache: | Englisch |
Jahr der Erstveröffentlichung: | 2019 |
Erscheinungsjahr: | 2019 |
Datum der Freischaltung: | 11.11.2020 |
Freies Schlagwort / Tag: | Caenorhabditis elegans; Oxidative stress; Selenium; Selenoneine |
Band: | 55 |
Seitenanzahl: | 4 |
Erste Seite: | 78 |
Letzte Seite: | 81 |
Fördernde Institution: | German Research Foundation (DFG)German Research Foundation (DFG) [SCHW 903/9-1, BO 4103/2-1]; Austrian Science Fund (FWF)Austrian Science Fund (FWF) [I 2262-N28]; DFG Research Unit TraceAgeGerman Research Foundation (DFG) [FOR 2558]; National Institute of Environmental Health SciencesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Environmental Health Sciences (NIEHS) [NIEHS R01ES07331, NIEHS R01ES10563, NIEHS R01ES020852] |
Organisationseinheiten: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft |
DDC-Klassifikation: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Peer Review: | Referiert |