Claudia Haegele, Florian Schlagenhauf, Michael A. Rapp, Philipp Sterzer, Anne Beck, Felix Bermpohl, Meline Stoy, Andreas Stroehle, Hans-Ulrich Wittchen, Raymond J. Dolan, Andreas Heinz
- A dimensional approach in psychiatry aims to identify core mechanisms of mental disorders across nosological boundaries.
We compared anticipation of reward between major psychiatric disorders, and investigated whether reward anticipation is impaired in several mental disorders and whether there is a common psychopathological correlate (negative mood) of such an impairment.
During reward anticipation, we observed significant group differences in ventral striatal (VS) activation: patients with schizophrenia, alcohol dependence, and major depression showed significantly less ventral striatal activation compared to healthy controls. Depressive symptoms correlated with dysfunction in reward anticipation regardless of diagnostic entity. There was no significant correlation between anxiety symptoms and VS functional activation.
Our findings demonstrate a neurobiological dysfunction related to reward prediction that transcended disorder categories and was related to measures of depressed mood. The findings underline the potential of aA dimensional approach in psychiatry aims to identify core mechanisms of mental disorders across nosological boundaries.
We compared anticipation of reward between major psychiatric disorders, and investigated whether reward anticipation is impaired in several mental disorders and whether there is a common psychopathological correlate (negative mood) of such an impairment.
During reward anticipation, we observed significant group differences in ventral striatal (VS) activation: patients with schizophrenia, alcohol dependence, and major depression showed significantly less ventral striatal activation compared to healthy controls. Depressive symptoms correlated with dysfunction in reward anticipation regardless of diagnostic entity. There was no significant correlation between anxiety symptoms and VS functional activation.
Our findings demonstrate a neurobiological dysfunction related to reward prediction that transcended disorder categories and was related to measures of depressed mood. The findings underline the potential of a dimensional approach in psychiatry and strengthen the hypothesis that neurobiological research in psychiatric disorders can be targeted at core mechanisms that are likely to be implicated in a range of clinical entities.…
MetadatenVerfasserangaben: | Claudia Haegele, Florian SchlagenhaufORCiDGND, Michael A. RappORCiDGND, Philipp Sterzer, Anne Beck, Felix Bermpohl, Meline Stoy, Andreas Stroehle, Hans-Ulrich WittchenORCiDGND, Raymond J. Dolan, Andreas HeinzORCiDGND |
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DOI: | https://doi.org/10.1007/s00213-014-3662-7 |
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ISSN: | 0033-3158 |
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ISSN: | 1432-2072 |
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Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/24973896 |
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Titel des übergeordneten Werks (Englisch): | Psychopharmacology |
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Verlag: | Springer |
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Verlagsort: | New York |
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Publikationstyp: | Wissenschaftlicher Artikel |
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Sprache: | Englisch |
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Jahr der Erstveröffentlichung: | 2015 |
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Erscheinungsjahr: | 2015 |
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Datum der Freischaltung: | 27.03.2017 |
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Freies Schlagwort / Tag: | Depressive symptoms; Dimensional; Monetary incentive delay task; Reward system; Ventral striatum; fMRI |
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Band: | 232 |
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Ausgabe: | 2 |
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Seitenanzahl: | 11 |
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Erste Seite: | 331 |
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Letzte Seite: | 341 |
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Fördernde Institution: | German Research Foundation (Deutsche Forschungsgemeinschaft) [HE 2597/4-3, 7-3, 15-1 (FOR1617), EXC 257, SCHL1969/1-1, 2-1, STE-1430/6-1, WI709/10-1]; Bundesministerium fur Bildung und Forschung [01GQ0411, 01KR1207C, 01GS08159] |
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Organisationseinheiten: | Humanwissenschaftliche Fakultät / Strukturbereich Kognitionswissenschaften / Department Sport- und Gesundheitswissenschaften |
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Peer Review: | Referiert |
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Name der Einrichtung zum Zeitpunkt der Publikation: | Humanwissenschaftliche Fakultät / Institut für Sportmedizin und Prävention |
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Externe Anmerkung: | Zweitveröffentlichung in der Schriftenreihe Postprints der Universität Potsdam : Humanwissenschaftliche Reihe ; 653 |
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