Separation of isomeric disaccharides by traveling wave ion mobility mass spectrometry using CO2 as drift gas
- The use of CO2 as a massive and polarizable drift gas is shown to greatly improve peak-to-peak resolution (Rp-p), as compared with N2, for the separation of disaccharides in a Synapt G2 traveling wave ion mobility cell. Near or baseline Rp-p was achieved for three pairs of sodiated molecules of disaccharide isomers, that is, cellobiose and sucrose (Rp-p?=?0.76), maltose and sucrose (Rp-p?=?1.04), and maltose and lactose (Rp-p?=?0.74). Ion mobility mass spectrometry using CO2 as the drift gas offers therefore an attractive alternative for fast and efficient separation of isomeric disaccharides.
| Author details: | Maira Fasciotti, Gustavo B. Sanvido, Vanessa G. Santos, Priscila M. Lalli, Michael McCullagh, Gilberto F. de Sa, Romeu J. Daroda, Martin G. Peter, Marcos N. Eberlin |
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| DOI: | https://doi.org/10.1002/jms.3089 |
| ISSN: | 1076-5174 |
| Title of parent work (English): | Journal of mass spectrometr |
| Publisher: | Wiley-Blackwell |
| Place of publishing: | Hoboken |
| Publication type: | Article |
| Language: | English |
| Year of first publication: | 2012 |
| Publication year: | 2012 |
| Release date: | 2017/03/26 |
| Tag: | isomer resolution; oligosaccharides; polarizable drift gases; traveling wave ion mobility mass spectrometry |
| Volume: | 47 |
| Issue: | 12 |
| Number of pages: | 5 |
| First page: | 1643 |
| Last Page: | 1647 |
| Funding institution: | Brazilian science foundation FAPESP; Brazilian science foundation CNPq; Brazilian science foundation CAPES; Brazilian science foundation FINEP |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
| Peer review: | Referiert |
