Edoardo Botteri, Giulia Peveri, Paula Berstad, Vincenzo Bagnardi, Sairah L. F. Chen, Torkjel M. Sandanger, Geir Hoff, Christina C. Dahm, Christian S. Antoniussen, Anne Tjonneland, Anne Kirstine Eriksen, Guri Skeie, Aurora Perez-Cornago, Jose Maria Huerta, Paula Jakszyn, Sophia Harlid, Bjoern Sundstroem, Aurelio Barricarte, Evelyn M. Monninkhof, Jeroen W. G. Derksen, Matthias Bernd Schulze, Bas Bueno-de-Mesquita, Maria-Jose Sanchez, Amanda J. Cross, Konstantinos K. Tsilidis, Maria Santucci De Magistris, Rudolf Kaaks, Verena Katzke, Joseph A. Rothwell, Nasser Laouali, Gianluca Severi, Pilar Amiano, Paolo Contiero, Carlotta Sacerdote, Marcel Goldberg, Mathilde Touvier, Heinz Freisling, Vivian Viallon, Elisabete Weiderpass, Elio Riboli, Marc J. Gunter, Mazda Jenab, Pietro Ferrari
- INTRODUCTION:
We investigated the impact of changes in lifestyle habits on colorectal cancer (CRC) risk in a multicountry European cohort.
METHODS:
We used baseline and follow-up questionnaire data from the European Prospective Investigation into Cancer cohort to assess changes in lifestyle habits and their associations with CRC development. We calculated a healthy lifestyle index (HLI) score based on smoking status, alcohol consumption, body mass index, and physical activity collected at the 2 time points. HLI ranged from 0 (most unfavorable) to 16 (most favorable). We estimated the association between HLI changes and CRC risk using Cox regression models and reported hazard ratios (HR) with 95% confidence intervals (CI).
RESULTS:
Among 295,865 participants, 2,799 CRC cases were observed over a median of 7.8 years. The median time between questionnaires was 5.7 years. Each unit increase in HLI from the baseline to the follow-up assessment was associated with a statistically significant 3% lower CRC risk. Among participantsINTRODUCTION:
We investigated the impact of changes in lifestyle habits on colorectal cancer (CRC) risk in a multicountry European cohort.
METHODS:
We used baseline and follow-up questionnaire data from the European Prospective Investigation into Cancer cohort to assess changes in lifestyle habits and their associations with CRC development. We calculated a healthy lifestyle index (HLI) score based on smoking status, alcohol consumption, body mass index, and physical activity collected at the 2 time points. HLI ranged from 0 (most unfavorable) to 16 (most favorable). We estimated the association between HLI changes and CRC risk using Cox regression models and reported hazard ratios (HR) with 95% confidence intervals (CI).
RESULTS:
Among 295,865 participants, 2,799 CRC cases were observed over a median of 7.8 years. The median time between questionnaires was 5.7 years. Each unit increase in HLI from the baseline to the follow-up assessment was associated with a statistically significant 3% lower CRC risk. Among participants in the top tertile at baseline (HLI > 11), those in the bottom tertile at follow-up (HLI <= 9) had a higher CRC risk (HR 1.34; 95% CI 1.02-1.75) than those remaining in the top tertile. Among individuals in the bottom tertile at baseline, those in the top tertile at follow-up had a lower risk (HR 0.77; 95% CI 0.59-1.00) than those remaining in the bottom tertile.
DISCUSSION:
Improving adherence to a healthy lifestyle was inversely associated with CRC risk, while worsening adherence was positively associated with CRC risk. These results justify and support recommendations for healthy lifestyle changes and healthy lifestyle maintenance for CRC prevention.…
MetadatenAuthor details: | Edoardo BotteriORCiD, Giulia Peveri, Paula Berstad, Vincenzo Bagnardi, Sairah L. F. Chen, Torkjel M. Sandanger, Geir Hoff, Christina C. Dahm, Christian S. Antoniussen, Anne Tjonneland, Anne Kirstine EriksenORCiD, Guri Skeie, Aurora Perez-CornagoORCiD, Jose Maria Huerta, Paula Jakszyn, Sophia Harlid, Bjoern Sundstroem, Aurelio Barricarte, Evelyn M. Monninkhof, Jeroen W. G. Derksen, Matthias Bernd SchulzeORCiDGND, Bas Bueno-de-Mesquita, Maria-Jose Sanchez, Amanda J. Cross, Konstantinos K. Tsilidis, Maria Santucci De Magistris, Rudolf Kaaks, Verena Katzke, Joseph A. Rothwell, Nasser Laouali, Gianluca Severi, Pilar Amiano, Paolo Contiero, Carlotta Sacerdote, Marcel GoldbergORCiD, Mathilde Touvier, Heinz Freisling, Vivian Viallon, Elisabete Weiderpass, Elio RiboliORCiD, Marc J. Gunter, Mazda Jenab, Pietro FerrariORCiD |
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DOI: | https://doi.org/10.14309/ajg.0000000000002065 |
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ISSN: | 0002-9270 |
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ISSN: | 1572-0241 |
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Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/36227801 |
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Title of parent work (English): | The American journal of gastroenterology : AJG |
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Publisher: | Lippincott Williams & Wilkins |
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Place of publishing: | Philadelphia |
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Publication type: | Article |
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Language: | English |
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Date of first publication: | 2022/10/12 |
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Publication year: | 2022 |
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Release date: | 2024/07/03 |
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Volume: | 118 |
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Issue: | 4 |
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Number of pages: | 10 |
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First page: | 702 |
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Last Page: | 711 |
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Funding institution: | French Institut National du Cancer (INCa) [AAP SHS-E-SP 2020];; International Agency for Research on Cancer (IARC); Department of; Epidemiology and Biostatistics, School of Public Health, Imperial; College London; Danish Cancer Society (Denmark); Ligue Contre le Cancer;; Institut Gustave Roussy; Mutuelle Generale de l'Education Nationale;; Institut National de la Sante et de la Recherche Medicale (INSERM); (France); German Cancer Aid; German Cancer Research Center (DKFZ);; German Institute of Human Nutrition PotsdamRehbruecke (DIfE); Federal; Ministry of Education and Research (BMBF) (Germany); Associazione; Italiana per la Ricerca sul Cancro-AIRC-Italy; Compagnia di SanPaolo;; National Research Council (Italy); Dutch Ministry of Public Health,; Welfare and Sports (VWS); Netherlands Cancer Registry (NKR); LK Research; Funds; Dutch Prevention Funds; Dutch ZON (Zorg Onderzoek Nederland);; World Cancer Research Fund (WCRF); Statistics Netherlands (The; Netherlands); Health Research Fund (FIS)-nstituto de Salud Carlos III; (ISCIII); Regional Government of Andalucia; Regional Government of; Asturias; Regional Government of Basque Country; Regional Government of; Murcia; Regional Government of Navarra; Catalan Institute of Oncology; (ICO) (Spain); Swedish Cancer Society; Swedish Research Council; County; Council of Skane; County Council of Vasterbotten (Sweden); Cancer; Research UK [14136, C8221/A29017]; Medical Research Council (United; Kingdom) [1000143, MR/M012190/1]; MRC [MR/M012190/1] Funding Source:; UKRI |
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Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft |
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DDC classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Peer review: | Referiert |
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