COX, LOX and platelet aggregation inhibitory properties of Lauraceae neolignans
- The anti-inflammatory potential of 26 neolignans (14 of the bicyclooctane-type and 12 of the benzofuran-type), isolated from three Lauraceae species (Pleurothyrium cinereum, Ocotea macrophylla and Nectandra amazonum), was evaluated in vitro through inhibition of COX-1, COX-2, 5-LOX and agonist-induced aggregation of rabbit platelets. Benzofuran neolignans were found to be selective COX-2 inhibitors, whereas bicyclooctane neolignans inhibit selectively the PAF- action as well as COX-1 and 5-LOX. The neolignan 9-nor-7,8-dehydro-isolicarin B 15 and cinerin C 7 were found to be the most potent COX-2 inhibitor and PAF-antagonist, respectively. Nectamazin C 10 exhibited dual 5-LOX/COX-2 inhibition.
Author details: | Ericsson David Coy-Barrera, Luis Enrique Cuca-Sußrez, Michael Sefkow |
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URL: | http://www.sciencedirect.com/science/journal/0960894X |
DOI: | https://doi.org/10.1016/j.bmcl.2009.10.069 |
ISSN: | 0960-894X |
Publication type: | Article |
Language: | English |
Year of first publication: | 2009 |
Publication year: | 2009 |
Release date: | 2017/03/25 |
Source: | Bioorganic & medicinal chemistry letters. - ISSN 0960-894X. - 19 (2009), 24, S. 6922 - 6925 |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
Peer review: | Referiert |