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Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica

  • The ethyl acetate extract of the stem bark of Erythrina abyssinica showed anti-plasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 values of 7.9 +/- 1.1 and 5.3 +/- 0.7 mug/ml, respectively. From this extract, a new chalcone, 2,3,4,4'-tetrahydroxy-5- prenylchalcone (trivial name 5-prenylbutein) and a new flavanone, 4',7-dihydroxy-3'-methoxy-5'- prenylflavanone (trivial name, 5-deoxyabyssinin II) along with known flavonoids have been isolated as the anti- plasmodial principles. The structures were determined on the basis of spectroscopic evidence. (C) 2004 Elsevier Ltd. All rights reserved

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Metadaten
Author:Abiy Yenesew, M. Induli, Solomon DereseORCiD, Jacob O. Midiwo, Matthias Heydenreich, Martin G. Peter, Hoseah M. Akala, Julia Wangui, Pamela Liyala, Norman C. Waters
ISSN:0031-9422
Document Type:Article
Language:English
Year of first Publication:2004
Year of Completion:2004
Release Date:2017/03/24
Source:Phytochemistry. - ISSN 0031-9422. - 65 (2004), 22, S. 3029 - 3032
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Peer Review:Referiert