Osmosensing, osmosignalling and inflammation
- Intervertebral disc (IVD) cells are naturally exposed to high osmolarity and complex mechanical loading, which drive microenvironmental osmotic changes. Age- and degeneration-induced degradation of the IVD's extracellular matrix causes osmotic imbalance, which, together with an altered function of cellular receptors and signalling pathways, instigates local osmotic stress. Cellular responses to osmotic stress include osmoadaptation and activation of pro-inflammatory pathways. This review summarises the current knowledge on how IVD cells sense local osmotic changes and translate these signals into physiological or pathophysiological responses, with a focus on inflammation. Furthermore, it discusses the expression and function of putative membrane osmosensors (e.g. solute carrier transporters, transient receptor potential channels, aquaporins and acid-sensing ion channels) and osmosignalling mediators [e.g. tonicity responseelement-binding protein/nuclear factor of activated T-cells 5 (TonEBP/NFAT5), nuclear factorIntervertebral disc (IVD) cells are naturally exposed to high osmolarity and complex mechanical loading, which drive microenvironmental osmotic changes. Age- and degeneration-induced degradation of the IVD's extracellular matrix causes osmotic imbalance, which, together with an altered function of cellular receptors and signalling pathways, instigates local osmotic stress. Cellular responses to osmotic stress include osmoadaptation and activation of pro-inflammatory pathways. This review summarises the current knowledge on how IVD cells sense local osmotic changes and translate these signals into physiological or pathophysiological responses, with a focus on inflammation. Furthermore, it discusses the expression and function of putative membrane osmosensors (e.g. solute carrier transporters, transient receptor potential channels, aquaporins and acid-sensing ion channels) and osmosignalling mediators [e.g. tonicity responseelement-binding protein/nuclear factor of activated T-cells 5 (TonEBP/NFAT5), nuclear factor kappa-lightchain-enhancer of activated B cells (NF-kappa B)] in healthy and degenerated IVDs. Finally, an overview of the potential therapeutic targets for modifying osmosensing and osmosignalling in degenerated IVDs is provided.…
Author details: | Aleksandra SadowskaORCiD, Takuya KamedaORCiD, Olga KrupkovaORCiDGND, Karin Würtz-KozakORCiDGND |
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URN: | urn:nbn:de:kobv:517-opus4-469080 |
DOI: | https://doi.org/10.25932/publishup-46908 |
ISSN: | 1866-8364 |
Title of parent work (German): | Postprints der Universität Potsdam : Humanwissenschaftliche Reihe |
Subtitle (English): | how intervertebral disc cells respond to altered osmolarity |
Publication series (Volume number): | Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe (693) |
Publication type: | Postprint |
Language: | English |
Date of first publication: | 2021/01/14 |
Publication year: | 2018 |
Publishing institution: | Universität Potsdam |
Release date: | 2021/01/14 |
Tag: | aquaporin; degenerative disc disease; hyper-osmolarity; hypo-osmolarity; inflammatory; intervertebral disc degeneration; osmolarity; osmotic; tonicity-responsive enhancer binding protein; transient receptor potential channel |
Issue: | 693 |
Number of pages: | 22 |
Source: | European Cells and Materials 36(2018), 231-250; DOI: 10.22203/eCM.v036a17 |
Organizational units: | Humanwissenschaftliche Fakultät / Strukturbereich Kognitionswissenschaften / Department Sport- und Gesundheitswissenschaften |
DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit | |
Peer review: | Referiert |
Publishing method: | Open Access / Green Open-Access |
License (German): | CC-BY-SA - Namensnennung, Weitergabe zu gleichen Bedingungen 4.0 International |