The crux of inept biomarkers for risks and benefits of trace elements
- Nowadays, the role of trace elements (TE) is of growing interest because dyshomeostasis of selenium (Se), manganese (Mn), zinc (Zn), and copper (Cu) is supposed to be a risk factor for several diseases. Thereby, research focuses on identifying new biomarkers for the TE status to allow for a more reliable description of the individual TE and health status. This review mirrors a lack of well-defined, sensitive, and selective biomarkers and summarizes technical limitations to measure them. Thus, the capacity to assess the relationship between dietary TE intake, homeostasis, and health is restricted, which would otherwise provide the basis to define adequate intake levels of single TE in both healthy and diseased humans. Besides that, our knowledge is even more limited with respect to the real life situation of combined TE intake and putative interactions between single TE.
| Author details: | Julia BornhorstORCiDGND, Anna P. Kipp, Hajo HaaseORCiD, Soeren Meyer, Tanja SchwerdtleORCiDGND |
|---|---|
| DOI: | https://doi.org/10.1016/j.trac.2017.11.007 |
| ISSN: | 0165-9936 |
| ISSN: | 1879-3142 |
| Title of parent work (English): | Trends in Analytical Chemistry |
| Publisher: | Elsevier |
| Place of publishing: | Oxford |
| Publication type: | Review |
| Language: | English |
| Date of first publication: | 2018/11/15 |
| Publication year: | 2018 |
| Release date: | 2021/11/15 |
| Tag: | Biomarker; Copper; Hyphenated techniques; Inductively coupled plasma mass spectrometry; Isotope ratios; Manganese; Selenium; Trace elements; Zinc |
| Volume: | 104 |
| Number of pages: | 8 |
| First page: | 183 |
| Last Page: | 190 |
| Funding institution: | NutriAct - Competence Cluster Nutrition Research Berlin-Potsdam - Federal Ministry of Education and Research [FKZ: 01EA1408B]; TraceAge - DFG Research Unit on Interactions of essential trace elements in healthy and diseased elderly, Potsdam Berlin-Jena [FOR 2558/1]; "Deutsche Forschungsgemeinschaft" (DFG)German Research Foundation (DFG) [Schw 903/9-1, BO 4103/2-1] |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
| Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft | |
| DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
| Peer review: | Referiert |
